MCID: LCH009
MIFTS: 46

Lichen Sclerosus malady

Rare diseases, Skin diseases categories

Summaries for Lichen Sclerosus

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Lichen sclerosus is a skin disorder that can affect men, women, or children, but is most common in women. it usually occurs on the vulva (the outer genitalia or sex organ) in women, but sometimes develops on the head of the penis in men. occasionally, lichen sclerosus is seen on other parts of the body, especially the upper body, breasts, and upper arms.  other names for lichen sclerosus include kraurosis vulvae and hypoplastic dystrophy. last updated: 1/8/2013

MalaCards: Lichen Sclerosus, also known as lichen sclerosus et atrophicus, is related to vitiligo and breast cancer. An important gene associated with Lichen Sclerosus is ECM1 (extracellular matrix protein 1), and among its related pathways are Cell adhesion ECM remodeling and Hematopoietic cell lineage. The compounds keratan sulfate and hydralazine have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related mouse phenotypes are muscle and normal.

Wikipedia:66 Lichen sclerosus (LS) (also termed, incorrectly, \"Lichen sclerosus et atrophicus\") is a disease of... more...

Aliases & Classifications for Lichen Sclerosus

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Sources:
44NIH Rare Diseases, 46Novoseek, 63UMLS, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

lichen sclerosus 44 46
lichen sclerosus et atrophicus 44 63
lichen sclerosis et atrophicus 44
lichen sclerosis 44


External Ids:

ICD1026 L90.0

Related Diseases for Lichen Sclerosus

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Lichen Sclerosus:



Diseases related to lichen sclerosus

Symptoms for Lichen Sclerosus

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Drugs & Therapeutics for Lichen Sclerosus

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Lichen Sclerosus

Search CenterWatch for Lichen Sclerosus

Genetic Tests for Lichen Sclerosus

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Anatomical Context for Lichen Sclerosus

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34MalaCards
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MalaCards organs/tissues related to Lichen Sclerosus:

34
Skin, Breast, T cells, Thyroid, Endothelial, Tongue

Animal Models for Lichen Sclerosus or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Lichen Sclerosus:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6ELN, RARB, HMBS, CD44
2MP:00028738.5CD8A, CD44, HMBS, RARB
3MP:00053908.0TYRP1, TIA1, ELN, RARB, CD44
4MP:00053978.0CD8A, CD44, RARB, TIA1, ECM1
5MP:00053877.8CD8A, CD44, RARB, TIA1, ECM1
6MP:00036317.6TYRP1, RARB, HMBS, CD44, CD8A
7MP:00107686.6CD8A, TYRP1, ECM1, TIA1, ELN, RARB

Publications for Lichen Sclerosus

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53PubMed
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Articles related to Lichen Sclerosus:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
Lichen sclerosus in a breast cancer survivor. (23288380)
2013
2
Differential gene hypermethylation in genital lichen sclerosus and cancer: a comparative study. (23998425)
2013
3
Long-term follow-up of women with genital lichen sclerosus. (23417579)
2013
4
Peristomal lichen sclerosus: the role of occlusion and urine exposure? (22913573)
2013
5
Protein markers of malignant potential in penile and vulvar lichen sclerosus. (23399649)
2013
6
Low-concentration topical tacrolimus for the treatment of anogenital lichen sclerosus in childhood: maintenance treatment to reduce recurrence. (24049806)
2013
7
High frequency of genital lichen sclerosus in a prospective series of 76 patients with morphea: toward a better understanding of the spectrum of morphea. (22004877)
2012
8
Clinical scoring system for vulvar lichen sclerosus. (22759453)
2012
9
Rates of self-reported urinary, gastrointestinal, and pain comorbidities in women with vulvar lichen sclerosus. (22622339)
2012
10
Coexistence of lichen sclerosus and morphea: a retrospective analysis of 472 patients with localized scleroderma from a German tertiary referral center. (22533994)
2012
11
Lichen sclerosus et atrophicans leading to joint contractures: restoration of joint mobility by extracorporeal photopheresis. (23158632)
2012
12
The surgical management of complications of vulval lichen sclerosus. (22397746)
2012
13
Topical interventions for genital lichen sclerosus. (22161424)
2011
14
A double-blind, randomized controlled trial of clobetasol versus pimecrolimus in patients with vulvar lichen sclerosus. (21353334)
2011
15
Risk factors for genital lichen sclerosus in men. (20973765)
2011
16
Acral lichen sclerosus et atrophicus--case report. (22068779)
2011
17
Coexistence of generalized morphea and lichen sclerosus et atrophicus mimicking systemic disease. (21548525)
2011
18
Imiquimod use in the genital area and development of lichen sclerosus and lichen planus. (20215634)
2010
19
Lichen sclerosus et atrophicus-like skin lesions in a patient carrying a novel hydroxymethylbilane synthase mutation. (20580577)
2010
20
Treatment of oral lichen sclerosus with 1% pimecrolimus cream. (20711272)
2010
21
Dermoscopy of extragenital lichen sclerosus. (20026867)
2009
22
Malignant transformation of penile lichen sclerosus: exactly how common is it? (19126024)
2008
23
Single base instability is promoted in vulvar lichen sclerosus. (17554370)
2007
24
Treatment of recalcitrant erosive vulvar lichen sclerosus with photodynamic therapy. (17637374)
2007
25
Vulvar melanoma in a 10-year-old girl in association with lichen sclerosus. (16427997)
2006
26
Rapid onset of acute carcinoma of the glans penis arising three years after a lichen sclerosus. (16280309)
2005
27
Lichen sclerosus. (16004624)
2005
28
Lichen sclerosus in children. (15763776)
2004
29
Development of multifocal squamous cell carcinoma in lichen sclerosus et atrophicus of the penis associated to HCV hepatitis. (14871263)
2004
30
Vasculitis in lichen sclerosus: an under recognized feature? (15330801)
2004
31
Pimecrolimus for the treatment of vulvar lichen sclerosus: a report of 4 cases. (15568399)
2004
32
Genital lichen sclerosus, squamous cell carcinoma and circumcision. (12786863)
2003
33
The role of angiogenesis in vulvar cancer, vulvar intraepithelial neoplasia, and vulvar lichen sclerosus as determined by microvessel density analysis. (12713988)
2003
34
TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva. (14676802)
2003
35
Pseudoepitheliomatous hyperplasia in lichen sclerosus of the vulva. (12496699)
2003
36
Overexpression of wild-type p53 in lichen sclerosus adjacent to human papillomavirus-negative vulvar cancer. (12445188)
2002
37
Perineoplasty for the treatment of introital stenosis related to vulvar lichen sclerosus. (11810083)
2002
38
Genital lichen sclerosus associated with incontinence. (12521711)
2002
39
Low-dose ultraviolet A1 phototherapy for extragenital lichen sclerosus: results of a preliminary study. (11807437)
2002
40
Chronic borreliosis presenting with morphea- and lichen sclerosus et atrophicus-like cutaneous lesions. a case report. (11455165)
2001
41
Concordant p53 and mdm-2 protein expression in vulvar squamous cell carcinoma and adjacent lichen sclerosus. (11396633)
2001
42
High incidence of lichen sclerosus in patients with squamous cell carcinoma of the penis. (11453912)
2001
43
Lichen sclerosus of the vulva. Long-term steroid maintenance therapy. (10442326)
1999
44
Does lichen sclerosus play a central role in the pathogenesis of human papillomavirus negative vulvar squamous cell carcinoma? The itch-scratch-lichen sclerosus hypothesis. (11240748)
1999
45
Squamous cell carcinoma of the penis arising on lichen sclerosus et atrophicus. (10343945)
1999
46
Composition of the inflammatory infiltrate in pediatric penile lichen sclerosus et atrophicus (balanitis xerotica obliterans): a prospective, comparative immunophenotyping study. (8008686)
1994
47
Advances in vulvar disease: lichen sclerosus et atrophicus et al. (1739579)
1992
48
Vulvar cicatricial pemphigoid as a lichen sclerosus imitator. A case report. (1619612)
1992
49
Treatment of localized scleroderma and lichen sclerosus with etretinate. (6203311)
1984
50
Balanitis xerotica obliterans manifesting on stump of amputated penis; report of an unusual case and remarks on the nature of lichen sclerosus et atrophicus. (13636433)
1959

Variations for Lichen Sclerosus

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Expression for genes affiliated with Lichen Sclerosus

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lichen Sclerosus

Search GEO for disease gene expression data for Lichen Sclerosus.

Pathways for genes affiliated with Lichen Sclerosus

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51PathCards, 61Thomson Reuters, 13EMD Millipore, 31KEGG
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Pathways related to Lichen Sclerosus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CD44, ELN
29.5CD8A, CD44
39.3CD44, ELN, ECM1

Compounds for genes affiliated with Lichen Sclerosus

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46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 3BitterDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Lichen Sclerosus according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1keratan sulfate4610.0CD44, ELN
2hydralazine46 52 1212.0RARB, ELN
3alginate4610.0CD44, ELN
4adapalene46 1211.0CD44, RARB
5dermatan sulfate4610.0ELN, CD44
6bleomycin46 1210.9CD44, ELN
7betacarotene469.9RARB, ELN
8chondroitin sulfate46 2510.9CD44, ELN
9azathioprine46 3 52 1212.7RARB, CD44
10glycosaminoglycan469.7ELN, CD44
11hmba469.7HMBS, TYRP1
12chloramphenicol46 3 52 1212.6CD44, RARB, ELN
13vitamin d469.6CD44, RARB, ELN
14actinomycin d469.5ELN, RARB, CD44
15agar469.5TYRP1, ELN, RARB
1612-o-tetradecanoylphorbol 13-acetate469.4TYRP1, RARB, CD44
17testosterone46 62 25 1212.4CD44, RARB, ELN
18cyclic amp46 2510.3TYRP1, RARB, CD44
19dexamethasone46 52 30 1212.2CD44, RARB, ELN
20ethanol46 52 25 1212.2HMBS, RARB, TYRP1
21progesterone46 30 62 25 1213.2RARB, HMBS, CD44
22paraffin469.2CD44, ELN, TIA1
23cysteine469.0TYRP1, ELN, RARB, CD44
24cycloheximide469.0ELN, RARB, HMBS, CD44
25steroid469.0CD44, RARB, TYRP1
26arginine469.0CD44, HMBS, RARB, ELN
27prednisolone46 30 1210.9CD44, TIA1
28adenylate468.7CD44, RARB, TIA1, TYRP1
29tyrosine468.6CD8A, CD44, RARB, TYRP1
30serine468.1TYRP1, TIA1, ELN, HMBS, CD44

GO Terms for genes affiliated with Lichen Sclerosus

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17Gene Ontology
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Biological processes related to Lichen Sclerosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:0226179.7CD44, ELN

Molecular functions related to Lichen Sclerosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.0CD8A, CD44, RARB, ELN, TIA1, ECM1

Products for genes affiliated with Lichen Sclerosus

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Lichen Sclerosus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet