MCID: LCH009
MIFTS: 42

Lichen Sclerosus malady

Rare diseases, Skin diseases categories

Summaries for Lichen Sclerosus

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NIH Rare Diseases:41 Lichen sclerosus is a skin disorder that can affect men, women, or children, but is most common in women. it usually occurs on the vulva (the outer genitalia or sex organ) in women, but sometimes develops on the head of the penis in men. occasionally, lichen sclerosus is seen on other parts of the body, especially the upper body, breasts, and upper arms.  other names for lichen sclerosus include kraurosis vulvae and hypoplastic dystrophy. last updated: 1/8/2013

MalaCards based summary: Lichen Sclerosus, also known as lichen sclerosus et atrophicus, is related to breast cancer and leukemia, and has symptoms including autosomal dominant inheritanceand squamous cell carcinoma. An important gene associated with Lichen Sclerosus is ECM1 (extracellular matrix protein 1), and among its related pathways are Cell adhesion ECM remodeling and Hematopoietic cell lineage. The compounds keratan sulfate and hydralazine have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related mouse phenotypes are muscle and normal.

Wikipedia:63 Lichen sclerosus (LS) (also termed, incorrectly, \"Lichen sclerosus et atrophicus\") is a disease of... more...

Aliases & Classifications for Lichen Sclerosus

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Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS, 25ICD10
See all sources

Lichen Sclerosus, Aliases & Descriptions:

Name: Lichen Sclerosus 41 43
Lichen Sclerosus Et Atrophicus 41 60
 
Lichen Sclerosis Et Atrophicus 41
Lichen Sclerosis 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


External Ids:

ICD1025 L90.0

Related Diseases for Lichen Sclerosus

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Graphical network of the top 20 diseases related to Lichen Sclerosus:



Diseases related to lichen sclerosus

Symptoms for Lichen Sclerosus

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HPO human phenotypes related to Lichen Sclerosus:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 squamous cell carcinoma HP:0002860

Drugs & Therapeutics for Lichen Sclerosus

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Drug clinical trials:

Search ClinicalTrials for Lichen Sclerosus

Search NIH Clinical Center for Lichen Sclerosus

Genetic Tests for Lichen Sclerosus

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Anatomical Context for Lichen Sclerosus

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MalaCards organs/tissues related to Lichen Sclerosus:

31
Skin, Breast, T cells, Thyroid, Endothelial, Tongue

Animal Models for Lichen Sclerosus or affiliated genes

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MGI Mouse Phenotypes related to Lichen Sclerosus:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6ELN, RARB, HMBS, CD44
2MP:00028738.5CD8A, CD44, HMBS, RARB
3MP:00053908.0TYRP1, TIA1, ELN, RARB, CD44
4MP:00053978.0CD8A, CD44, RARB, TIA1, ECM1
5MP:00053877.8CD8A, CD44, RARB, TIA1, ECM1
6MP:00036317.6TYRP1, RARB, HMBS, CD44, CD8A
7MP:00107686.6CD8A, TYRP1, ECM1, TIA1, ELN, RARB

Publications for Lichen Sclerosus

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Articles related to Lichen Sclerosus:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Conscious sedation with inhaled 50% nitrous oxide/oxygen premix in photodynamic therapy sessions for vulvar lichen sclerosus treatment. (25672311)
2015
2
Colocalization of nonsegmental vitiligo and extragenital lichen sclerosus in a 45-year-old female patient with Hashimoto's thyroiditis. (25615429)
2015
3
Oral lichen sclerosus expressing extracellular matrix proteins and IgG4-positive plasma cells. (25244166)
2014
4
Responses to the McGill Pain Questionnaire Predict Neuropathic Pain Medication Use in Women in With Vulvar Lichen Sclerosus. (25036743)
2014
5
The impact of vulvar lichen sclerosus on sexual dysfunction. (25162790)
2014
6
Reconstructive surgery of the sulcus of glans penis for balanopreputial adhesion due to lichen sclerosus. Our experience and medicolegal implications. (24901311)
2014
7
Lichen sclerosus in a breast cancer survivor. (23288380)
2013
8
Differential gene hypermethylation in genital lichen sclerosus and cancer: a comparative study. (23998425)
2013
9
What is lichen sclerosus? (24701651)
2013
10
Long-term follow-up of women with genital lichen sclerosus. (23417579)
2013
11
Peristomal lichen sclerosus: the role of occlusion and urine exposure? (22913573)
2013
12
Protein markers of malignant potential in penile and vulvar lichen sclerosus. (23399649)
2013
13
High frequency of genital lichen sclerosus in a prospective series of 76 patients with morphea: toward a better understanding of the spectrum of morphea. (22004877)
2012
14
Clinical scoring system for vulvar lichen sclerosus. (22759453)
2012
15
Coexistence of lichen sclerosus and morphea: a retrospective analysis of 472 patients with localized scleroderma from a German tertiary referral center. (22533994)
2012
16
Rates of self-reported urinary, gastrointestinal, and pain comorbidities in women with vulvar lichen sclerosus. (22622339)
2012
17
Topical interventions for genital lichen sclerosus. (22161424)
2011
18
A double-blind, randomized controlled trial of clobetasol versus pimecrolimus in patients with vulvar lichen sclerosus. (21353334)
2011
19
Risk factors for genital lichen sclerosus in men. (20973765)
2011
20
Acral lichen sclerosus et atrophicus--case report. (22068779)
2011
21
Coexistence of generalized morphea and lichen sclerosus et atrophicus mimicking systemic disease. (21548525)
2011
22
Imiquimod use in the genital area and development of lichen sclerosus and lichen planus. (20215634)
2010
23
Lichen sclerosus et atrophicus-like skin lesions in a patient carrying a novel hydroxymethylbilane synthase mutation. (20580577)
2010
24
Treatment of oral lichen sclerosus with 1% pimecrolimus cream. (20711272)
2010
25
Dermoscopy of extragenital lichen sclerosus. (20026867)
2009
26
Malignant transformation of penile lichen sclerosus: exactly how common is it? (19126024)
2008
27
Single base instability is promoted in vulvar lichen sclerosus. (17554370)
2007
28
Vulvar melanoma in a 10-year-old girl in association with lichen sclerosus. (16427997)
2006
29
Rapid onset of acute carcinoma of the glans penis arising three years after a lichen sclerosus. (16280309)
2005
30
Lichen sclerosus. (16004624)
2005
31
Lichen sclerosus in children. (15763776)
2004
32
Development of multifocal squamous cell carcinoma in lichen sclerosus et atrophicus of the penis associated to HCV hepatitis. (14871263)
2004
33
Vasculitis in lichen sclerosus: an under recognized feature? (15330801)
2004
34
Genital lichen sclerosus, squamous cell carcinoma and circumcision. (12786863)
2003
35
The role of angiogenesis in vulvar cancer, vulvar intraepithelial neoplasia, and vulvar lichen sclerosus as determined by microvessel density analysis. (12713988)
2003
36
TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva. (14676802)
2003
37
Overexpression of wild-type p53 in lichen sclerosus adjacent to human papillomavirus-negative vulvar cancer. (12445188)
2002
38
Perineoplasty for the treatment of introital stenosis related to vulvar lichen sclerosus. (11810083)
2002
39
Genital lichen sclerosus associated with incontinence. (12521711)
2002
40
Chronic borreliosis presenting with morphea- and lichen sclerosus et atrophicus-like cutaneous lesions. a case report. (11455165)
2001
41
Nail dystrophy due to lichen sclerosus? (11678877)
2001
42
Concordant p53 and mdm-2 protein expression in vulvar squamous cell carcinoma and adjacent lichen sclerosus. (11396633)
2001
43
Lichen sclerosus of the vulva. Long-term steroid maintenance therapy. (10442326)
1999
44
Does lichen sclerosus play a central role in the pathogenesis of human papillomavirus negative vulvar squamous cell carcinoma? The itch-scratch-lichen sclerosus hypothesis. (11240748)
1999
45
Squamous cell carcinoma of the penis arising on lichen sclerosus et atrophicus. (10343945)
1999
46
Composition of the inflammatory infiltrate in pediatric penile lichen sclerosus et atrophicus (balanitis xerotica obliterans): a prospective, comparative immunophenotyping study. (8008686)
1994
47
Advances in vulvar disease: lichen sclerosus et atrophicus et al. (1739579)
1992
48
Vulvar cicatricial pemphigoid as a lichen sclerosus imitator. A case report. (1619612)
1992
49
Treatment of localized scleroderma and lichen sclerosus with etretinate. (6203311)
1984
50
Balanitis xerotica obliterans manifesting on stump of amputated penis; report of an unusual case and remarks on the nature of lichen sclerosus et atrophicus. (13636433)
1959

Variations for Lichen Sclerosus

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Expression for genes affiliated with Lichen Sclerosus

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Search GEO for disease gene expression data for Lichen Sclerosus.

Pathways for genes affiliated with Lichen Sclerosus

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Pathways related to Lichen Sclerosus according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Metalloproteases in connective tissue degradation
9.7CD44, ELN
29.5CD8A, CD44
39.3CD44, ELN, ECM1

Compounds for genes affiliated with Lichen Sclerosus

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Compounds related to Lichen Sclerosus according to GeneCards Suite gene sharing:

(show all 30)
idCompoundScoreTop Affiliating Genes
1keratan sulfate4310.0CD44, ELN
2hydralazine43 49 1212.0RARB, ELN
3alginate4310.0CD44, ELN
4adapalene43 1211.0CD44, RARB
5dermatan sulfate4310.0ELN, CD44
6bleomycin43 1210.9CD44, ELN
7betacarotene439.9RARB, ELN
8chondroitin sulfate43 2410.9CD44, ELN
9azathioprine43 2 49 1212.7RARB, CD44
10glycosaminoglycan439.7ELN, CD44
11hmba439.7HMBS, TYRP1
12chloramphenicol43 2 49 1212.6CD44, RARB, ELN
13vitamin d439.6CD44, RARB, ELN
14actinomycin d439.5ELN, RARB, CD44
15agar439.5TYRP1, ELN, RARB
1612-o-tetradecanoylphorbol 13-acetate439.4TYRP1, RARB, CD44
17testosterone43 59 24 1212.4CD44, RARB, ELN
18cyclic amp43 2410.3TYRP1, RARB, CD44
19dexamethasone43 49 28 1212.2CD44, RARB, ELN
20ethanol43 49 24 1212.2HMBS, RARB, TYRP1
21progesterone43 28 59 24 1213.2RARB, HMBS, CD44
22paraffin439.2CD44, ELN, TIA1
23cysteine439.0TYRP1, ELN, RARB, CD44
24cycloheximide439.0ELN, RARB, HMBS, CD44
25steroid439.0CD44, RARB, TYRP1
26arginine439.0CD44, HMBS, RARB, ELN
27prednisolone43 28 1210.9CD44, TIA1
28adenylate438.7CD44, RARB, TIA1, TYRP1
29tyrosine438.6CD8A, CD44, RARB, TYRP1
30serine438.1TYRP1, TIA1, ELN, HMBS, CD44

GO Terms for genes affiliated with Lichen Sclerosus

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Biological processes related to Lichen Sclerosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:00226179.7CD44, ELN

Molecular functions related to Lichen Sclerosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055157.0CD8A, CD44, RARB, ELN, TIA1, ECM1

Products for genes affiliated with Lichen Sclerosus

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Sources for Lichen Sclerosus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet