MCID: LCH009
MIFTS: 37

Lichen Sclerosus malady

Skin diseases category

Summaries for Lichen Sclerosus

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Lichen sclerosus is a skin disorder that can affect men, women, or children, but is most common in women. it usually occurs on the vulva (the outer genitalia or sex organ) in women, but sometimes develops on the head of the penis in men. occasionally, lichen sclerosus is seen on other parts of the body, especially the upper body, breasts, and upper arms.  other names for lichen sclerosus include kraurosis vulvae and hypoplastic dystrophy. last updated: 1/8/2013

MalaCards: Lichen Sclerosus, also known as lichen sclerosus et atrophicus, is related to squamous cell carcinoma and lichen planus. An important gene associated with Lichen Sclerosus is ECM1 (extracellular matrix protein 1), and among its related pathways are Immune response IL-12-induced IFN-gamma production and Downstream signaling in naive CD8+ T cells. The compounds cycloheximide and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin and breast, and related mouse phenotypes are reproductive system and immune system.

Wikipedia:63 Lichen sclerosus (LS) (also termed, incorrectly, \"Lichen sclerosus et atrophicus\") is a disease of... more...

Aliases & Classifications for Lichen Sclerosus

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42NIH Rare Diseases, 44Novoseek, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

lichen sclerosus 42 44
lichen sclerosus et atrophicus 42 60
lichen sclerosis et atrophicus 42
lichen sclerosis 42


External Ids:

ICD1025 L90.0

Related Diseases for Lichen Sclerosus

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17GeneCards, 18GeneDecks
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Diseases related to Lichen Sclerosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.3RARB, CD44, ECM1, IVL, S100A7, GZMB
2lichen planus31.0COL17A1, GZMB, ITGAL, IVL
3hepatitis30.6IL2RB, GZMB
4graft versus host disease30.6GZMB, ITGAL, IL2RB
5vitiligo30.5CD8A, TYRP1, MLANA
6psoriasis30.5RNASE7, CD69, IVL, ITGAL, S100A7, GZMB
7breast cancer30.5GZMB, S100A7, IVL, ECM1, CD44, RARB
8melanoma30.5GZMB, AMBP, TIA1, MLANA, TYRP1, SRD5A1
9bullous pemphigoid30.4COL17A1
10mycosis fungoides30.4TIA1, GZMB, ITGAL, IL2RB
11panniculitis30.1TIA1
12sarcoma30.1MLANA
13sarcoidosis30.1GZMB, HLA-DQB1, CD69, IL2RB
14cutaneous t cell lymphoma30.1IL2RB, ITGAL, GZMB, TIA1
15multiple sclerosis30.1HLA-DQB1, ITGAL, CD69, IL2RB
16diabetes mellitus30.1AMBP, HLA-DQB1
17arthritis30.1AMBP, GZMB, CD44, CD69, IL2RB
18systemic lupus erythematosus30.1HLA-DQB1, ITGAL, CD69, IL2RB
19rheumatoid arthritis30.1AMBP, GZMB, HLA-DQB1, ITGAL, CD44, CD69
20leukemia30.1TIA1, GZMB, ITGAL, IVL, CD44, IL2RB
21lichen disease10.8
22penis squamous cell carcinoma10.6
23urethritis10.6
24balanitis xerotica obliterans10.6
25balanitis10.6
26phimosis10.6
27vulva squamous cell carcinoma10.5
28urethral stricture10.5
29vulvar disease10.5
30granuloma annulare10.3
31thyroiditis10.3
32vaginitis10.3
33burn scar10.3
34burns10.3
35vulvar dystrophy10.3
36hepatitis c10.3
37autoimmune thyroiditis10.3
38vulvovaginitis10.3
39cicatricial pemphigoid10.3
40localized scleroderma10.3
41verrucous carcinoma10.3
42fasciitis10.3
43histiocytosis10.3
44keratosis10.3
45langerhans-cell histiocytosis10.3
46lupus erythematosus10.3
47scleroderma10.3
48coronary artery disease10.1
49prolactinoma10.1
50acrodermatitis10.1

Graphical network of the top 20 diseases related to Lichen Sclerosus:



Diseases related to lichen sclerosus

Clinical Features for Lichen Sclerosus

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Drugs & Therapeutics for Lichen Sclerosus

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Lichen Sclerosus

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Anatomical Context for Lichen Sclerosus

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32MalaCards
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MalaCards organs/tissues related to Lichen Sclerosus:

32
Skin, Breast

Animal Models for Lichen Sclerosus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lichen Sclerosus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.7AMBP, HLA-DQB1, TYRP1, CD44, IL2RB, RARB
2MP:00053879.5GZMB, IL2RB, CD8A, CD69, CD44, ECM1
3MP:00107689.4ELN, COL17A1, HMBS, RARB, IL2RB, CD8A
4MP:00053979.3TIA1, GZMB, HLA-DQB1, ITGAL, CD44, CD69

Publications for Lichen Sclerosus

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Genetic Variations for Lichen Sclerosus

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Expression for genes affiliated with Lichen Sclerosus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lichen Sclerosus

Search GEO for disease gene expression data for Lichen Sclerosus.

Pathways for genes affiliated with Lichen Sclerosus

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Sources:
12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Lichen Sclerosus

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Lichen Sclerosus according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7ELN, IL2RB, COL17A1
2dexamethasone44 49 28 1113.6GZMB, ITGAL, RARB
3pge24410.6CD44, RARB, ITGAL
4hydralazine44 49 1112.6RARB, ELN, ITGAL
5chondroitin sulfate44 2411.6IVL, ELN, AMBP
6ivig4410.5IL2RB, ELN
7gold4410.5GZMB, IL2RB, COL17A1, IVL
8carbohydrates4410.4AMBP, ELN, CD69, CD44
9prednisolone44 28 1112.4CD44, ITGAL, GZMB, TIA1, IL2RB
10azathioprine44 49 2 1113.4GZMB, ITGAL, CD44, IL2RB, RARB
11heparan sulfate44 2411.4CD44, IVL, GZMB, ELN, AMBP
12hyaluronic acid44 2411.4ELN, AMBP, GZMB, ITGAL, CD44
13ionomycin4410.4CD69, CD44, ITGAL, IL2RB
14polysaccharide4410.4ELN, CD44, IVL, IL2RB, CD69
15phosphatidylserine44 28 1112.4IL2RB, ITGAL, CD44, GZMB
16ethanol44 49 11 2413.4TYRP1, HMBS, RARB, ITGAL, GZMB
17vitamin d4410.4IVL, CD44, RARB, ELN, SRD5A1
18tacrolimus44 49 1112.4CD69, ITGAL, GZMB, IL2RB
19glucose4410.4HMBS, GZMB, AMBP, CD44, IVL
2012-o-tetradecanoylphorbol 13-acetate4410.4RARB, GZMB, TYRP1, IVL, IL2RB, CD44
21sucrose44 11 2412.3COL17A1, CD44, TYRP1, ITGAL
22calcitriol44 59 11 2413.3SRD5A1, RARB, IVL, ITGAL, CD44
23paraffin4410.3ELN, CD44, IVL, TIA1, GZMB, MLANA
24actinomycin d4410.3ELN, RARB, CD69, CD44, ITGAL
25genistein44 28 59 2 11 2415.3RARB, CD69, IL2RB, ELN, SRD5A1
26proline4410.3COL17A1, ELN, IL2RB, IVL, ITGAL
27cisplatin44 49 59 1113.3RARB, GZMB, ITGAL, CD44, IL2RB, AMBP
28chloramphenicol44 2 1112.3RARB, IVL, CD44, ELN
29aspartate4410.3ELN, IL2RB, AMBP
30arginine4410.2CD44, IL2RB, ELN, HMBS, RARB, GZMB
31lactate4410.2AMBP, GZMB, MLANA, IVL, IL2RB, ELN
32vegf4410.2ELN, SRD5A1, IL2RB, CD44, IVL, GZMB
33cyclosporin a44 28 5912.2AMBP, IL2RB, ITGAL, CD69, CD44, GZMB
34thymidine44 2411.2IVL, CD69, RARB, IL2RB, CD44
35hematoxylin4410.2MLANA, ELN, IVL
36estrogen4410.2RARB, CD44, IVL, S100A7, SRD5A1, GZMB
37nitric oxide44 11 2412.2GZMB, HMBS, IL2RB, ITGAL, CD44, CD69
38creatinine4410.1AMBP, ELN, CD44, CD69, IL2RB
39cysteine4410.1RARB, TYRP1, ITGAL, AMBP, GZMB, ELN
40oxygen44 2411.1CD44, GZMB, IL2RB, CD69, S100A7, ITGAL
41retinoid4410.1RARB, ELN, IL2RB, IVL
42alanine4410.1IL2RB, CD44, ITGAL, GZMB, AMBP, ELN
43lipid4410.0RARB, AMBP, ITGAL, IVL, CD44, GZMB
44serine4410.0GZMB, AMBP, COL17A1, IL2RB, IVL, TYRP1
45steroid449.9IL2RB, RARB, SRD5A1, GZMB, CD44, TYRP1
46retinoic acid44 2410.9CD44, AMBP, GZMB, ITGAL, IVL, IL2RB
47heparin44 28 11 2412.9ELN, CD44, GZMB, ITGAL, CD69
48betacarotene449.9ELN, RARB, IVL
49tyrosine449.9IVL, GZMB, HLA-DQB1, ITGAL, COL17A1, IL2RB
50calcium44 49 11 2412.7COL17A1, CD44, TYRP1, IVL, ITGAL, S100A7

GO Terms for genes affiliated with Lichen Sclerosus

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16Gene Ontology
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Cellular components related to Lichen Sclerosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.9COL17A1, MLANA, CD44, CD69, CD8A, IL2RB
2external side of plasma membraneGO:0098979.7ITGAL, CD44, CD69, CD8A, IL2RB

Molecular functions related to Lichen Sclerosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.3ELN, TIA1, AMBP, GZMB, S100A7, ITGAL

Products for genes affiliated with Lichen Sclerosus

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  • Antibodies
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Sources for Lichen Sclerosus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet