MCID: LCH009
MIFTS: 47

Lichen Sclerosus malady

Skin category

Summaries for Lichen Sclerosus

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Lichen sclerosus is a skin disorder that can affect men, women, or children, but is most common in women. it usually occurs on the vulva (the outer genitalia or sex organ) in women, but sometimes develops on the head of the penis in men. occasionally, lichen sclerosus is seen on other parts of the body, especially the upper body, breasts, and upper arms.  other names for lichen sclerosus include kraurosis vulvae and hypoplastic dystrophy. last updated: 1/8/2013

MalaCards: Lichen Sclerosus, also known as lichen sclerosus et atrophicus, is related to squamous cell carcinoma and lichen planus. An important gene associated with Lichen Sclerosus is ECM1 (extracellular matrix protein 1), and among its related pathways are Immune response IL-12-induced IFN-gamma production and Downstream signaling in naive CD8+ T cells. The compounds cycloheximide and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and thyroid, and related mouse phenotypes are reproductive system and immune system.

Wikipedia:64 Lichen sclerosus (LS) (also termed, incorrectly, \"Lichen sclerosus et atrophicus\") is a disease of... more...

Aliases & Classifications for Lichen Sclerosus

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

lichen sclerosus 43 45
lichen sclerosus et atrophicus 43 61
lichen sclerosis et atrophicus 43
lichen sclerosis 43


External Ids:

ICD1025 L90.0

Related Diseases for Lichen Sclerosus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Lichen Sclerosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.4S100A7, IVL, GZMB, ECM1, CD44, COL17A1
2lichen planus31.0IVL, ITGAL, GZMB, COL17A1
3vitiligo30.6MLANA, TYRP1, CD8A
4graft versus host disease30.6GZMB, IL2RB, ITGAL
5bullous pemphigoid30.4COL17A1
6mycosis fungoides30.4IL2RB, ITGAL, TIA1, GZMB
7arthritis30.2CD69, CD44, GZMB, AMBP, IL2RB
8systemic lupus erythematosus30.2ITGAL, IL2RB, CD69, HLA-DQB1
9vulva squamous cell carcinoma10.8
10balanitis xerotica obliterans10.6
11balanitis10.6
12urethral stricture10.5
13vulvar intraepithelial neoplasia10.5
14atrophic vulva10.5
15vulvar disease10.5
16squamous cell papilloma10.4
17anal squamous cell carcinoma10.4
18vulva cancer10.4
19granuloma annulare10.4
20chronic graft versus host disease10.4
21atopy10.4
22burn scar10.3
23vulvar dystrophy10.3
24hepatitis c10.3
25autoimmune thyroiditis10.3
26cicatricial pemphigoid10.3
27localized scleroderma10.3
28hepatitis d10.3
29verrucous carcinoma10.3
30hepatitis a10.3
31thyroiditis10.3
32turner syndrome10.3
33vulvar squamous papilloma10.3
34atrophic lichen planus10.3
35burns10.1
36coronary artery disease,10.1
37prolactinoma10.1
38acrodermatitis10.1
39cutaneous lupus erythematosus10.1
40ainhum10.1
41keratoconjunctivitis sicca10.1
42bacterial vaginosis10.1
43trachoma10.1
44carpal tunnel syndrome10.1
45vulvovaginal candidiasis10.1
46hypospadias10.1
47spindle cell carcinoma10.1
48pellagra10.1
49penis sarcoma10.1
50vulvar melanoma10.1

Graphical network of the top 20 diseases related to Lichen Sclerosus:



Diseases related to lichen sclerosus

Clinical Features for Lichen Sclerosus

Drugs & Therapeutics for Lichen Sclerosus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lichen Sclerosus

Drug clinical trials:

Search ClinicalTrials for Lichen Sclerosus

Search NIH Clinical Center for Lichen Sclerosus

Search CenterWatch for Lichen Sclerosus

Genetic Tests for Lichen Sclerosus

Anatomical Context for Lichen Sclerosus

Sources:
33MalaCards
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MalaCards organs/tissues related to Lichen Sclerosus:

33
Skin, Tongue, Thyroid, Breast, T cells, B cells, Endothelial, Fetal thyroid

Animal Models for Lichen Sclerosus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Lichen Sclerosus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.7AMBP, HLA-DQB1, TYRP1, CD44, IL2RB, RARB
2MP:00053879.5GZMB, IL2RB, CD8A, CD69, CD44, ECM1
3MP:00107689.4ELN, COL17A1, HMBS, RARB, IL2RB, CD8A
4MP:00053979.3TIA1, GZMB, HLA-DQB1, ITGAL, CD44, CD69

Publications for Lichen Sclerosus

Sources:
51PubMed
See all sources

Articles related to Lichen Sclerosus:

(show top 50)    (show all 519)
idTitleAuthorsYear
1
Lichen sclerosus in a breast cancer survivor. (23288380)
2013
2
Atopy, the barrier, urine and genital lichen sclerosus: reply from the authors. (23909607)
2013
3
Association of autoimmune diseases with lichen sclerosus in 532 male and female patients. (23224274)
2013
4
Surgical division of labial adhesions in vulvar lichen sclerosus and lichen planus. (22885642)
2013
5
Proactive maintenance therapy with a topical corticosteroid for vulvar lichen sclerosus: preliminary results of a randomized study. (23398459)
2013
6
Quality of life in Dutch women with lichen sclerosus. (23252667)
2013
7
Lichen sclerosus and squamous cell carcinoma. (22445563)
2012
8
Metalloproteinases 2 and 9 and their tissue inhibitors 1 and 2 are increased in vulvar lichen sclerosus. (22200256)
2012
9
Childhood lichen sclerosus is a rare but important diagnosis. (22549488)
2012
10
Topical interventions for genital lichen sclerosus. (22161424)
2011
11
Health-related quality of life and patient-defined benefit of clobetasol 0.05% in women with chronic lichen sclerosus of the vulva. (21997592)
2011
12
Lichen sclerosus et atrophicus-like skin lesions in a patient carrying a novel hydroxymethylbilane synthase mutation. (20580577)
2010
13
British Association of Dermatologists' guidelines for the management of lichen sclerosus 2010. (20854400)
2010
14
Vulvitis plasmacellularis circumscripta in pre-existing lichen sclerosus: treatment with imiquimod 5% cream. (20542167)
2010
15
Lichen sclerosus: treatment and follow-up at the departments of gynaecology and dermatology. (20354420)
2010
16
Childhood lichen sclerosus: a long-term follow-up. (20199428)
2010
17
The effect of topical pimecrolimus on inflammatory infiltrate in vulvar lichen sclerosus. (19889396)
2010
18
The prognostic value of blood and lymph vessel parameters in lichen sclerosus for vulvar squamous cell carcinoma development: an immunohistochemical and electron microscopy study. (20417485)
2010
19
Childhood vulval lichen sclerosus: autoimmunity to the basement membrane zone protein BP180 and its relationship to autoimmunity. (20456392)
2010
20
Editorial comment on: Lichen sclerosus of the male genitalia and urethra: surgical options and results in a multicenter international experience with 215 patients. (18691806)
2009
21
Vulvar lichen sclerosus in the elderly: pathophysiology and treatment update. (19761274)
2009
22
Plantar involvement in lichen sclerosus. (19538384)
2009
23
Hypoxia-ischaemia is involved in the pathogenesis of vulvar lichen sclerosus. (20055833)
2009
24
Paediatric vulval lichen sclerosus. (19916966)
2009
25
Comparative treatment of extragenital lichen sclerosus with methylaminolevulinic Acid pulsed dye laser-mediated photodynamic therapy or pulsed dye laser alone. (19389089)
2009
26
Lichen sclerosus of the oral mucosa: clinicopathological features of six cases. (19395238)
2009
27
Topical tacrolimus for recalcitrant vulvar lichen sclerosus. (19502156)
2009
28
Lichen sclerosus of the male genitalia and urethra: surgical options and results in a multicenter international experience with 215 patients. (18691809)
2009
29
A case of simultaneously occurring lichen sclerosus and segmental vitiligo: connecting the underlying autoimmune pathogenesis. (18986354)
2008
30
Early onset vulvar Lichen Sclerosus in premenopausal women and oral contraceptives. (18055095)
2008
31
Vulvar lichen sclerosus: effect of maintenance treatment with a moisturizer on the course of the disease. (17603391)
2008
32
Extragenital lichen sclerosus of childhood presenting as erythematous patches. (18187829)
2008
33
The role of angiogenesis and COX-2 expression in the evolution of vulvar lichen sclerosus to squamous cell carcinoma of the vulva. (17560634)
2007
34
Vulvar lichen sclerosus: 11 women treated with tacrolimus 0.1% ointment. (17225019)
2007
35
Fetal microchimerism is not involved in the pathogenesis of lichen sclerosus of the vulva. (16470677)
2006
36
Detailed analysis of the T-cell lymphocytic infiltrate in penile lichen sclerosus: an immunohistochemical and molecular investigation. (16681690)
2006
37
HLA markers in familial Lichen sclerosus. (17010173)
2006
38
Lichen sclerosus: are there really no long-term disturbances in sexual function? (16303084)
2005
39
Heroic measures may not always be justified in extensive urethral stricture due to lichen sclerosus (balanitis xerotica obliterans). (15351594)
2004
40
TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva. (14676802)
2003
41
Lichen sclerosus of the vulva in women: assessment, diagnosis, and management for the nurse practitioner. (12696541)
2003
42
Topical mometasone furoate for vulvar lichen sclerosus. (12856516)
2003
43
Palmo-plantar lichen sclerosus et atrophicus. (17642827)
2003
44
Autoantibodies to extracellular matrix protein 1 in lichen sclerosus. (12867112)
2003
45
Lichen sclerosus. A review. (12032440)
2002
46
Guidelines for the management of lichen sclerosus. (12366407)
2002
47
Extragenital pigmented lichen sclerosus. (11204533)
2000
48
Does lichen sclerosus play a central role in the pathogenesis of human papillomavirus negative vulvar squamous cell carcinoma? The itch-scratch-lichen sclerosus hypothesis. (11240748)
1999
49
Advances in vulvar disease: lichen sclerosus et atrophicus et al. (1739579)
1992
50
Lichen sclerosus et atrophicus. A common and distinctive cause of phimosis in boys. (6465907)
1984

Genetic Variations for Lichen Sclerosus

Expression for genes affiliated with Lichen Sclerosus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lichen Sclerosus

Search GEO for disease gene expression data for Lichen Sclerosus.

Pathways for genes affiliated with Lichen Sclerosus

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 4Cell Signaling Technology, 30KEGG, 52QIAGEN
See all sources

Compounds for genes affiliated with Lichen Sclerosus

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Lichen Sclerosus according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7ELN, IL2RB, COL17A1
2dexamethasone45 50 29 1113.6GZMB, ITGAL, RARB
3pge24510.6CD44, RARB, ITGAL
4hydralazine45 50 1112.6RARB, ELN, ITGAL
5chondroitin sulfate45 2411.6IVL, ELN, AMBP
6ivig4510.5IL2RB, ELN
7gold4510.5GZMB, IL2RB, COL17A1, IVL
8carbohydrates4510.4AMBP, ELN, CD69, CD44
9prednisolone45 29 1112.4CD44, ITGAL, GZMB, TIA1, IL2RB
10azathioprine45 50 2 1113.4GZMB, ITGAL, CD44, IL2RB, RARB
11heparan sulfate45 2411.4CD44, IVL, GZMB, ELN, AMBP
12hyaluronic acid45 2411.4ELN, AMBP, GZMB, ITGAL, CD44
13ionomycin4510.4CD69, CD44, ITGAL, IL2RB
14polysaccharide4510.4ELN, CD44, IVL, IL2RB, CD69
15phosphatidylserine45 29 1112.4IL2RB, ITGAL, CD44, GZMB
16ethanol45 50 11 2413.4TYRP1, HMBS, RARB, ITGAL, GZMB
17vitamin d4510.4IVL, CD44, RARB, ELN, SRD5A1
18tacrolimus45 50 1112.4CD69, ITGAL, GZMB, IL2RB
19glucose4510.4HMBS, GZMB, AMBP, CD44, IVL
2012-o-tetradecanoylphorbol 13-acetate4510.4RARB, GZMB, TYRP1, IVL, IL2RB, CD44
21sucrose45 11 2412.3COL17A1, CD44, TYRP1, ITGAL
22calcitriol45 60 11 2413.3SRD5A1, RARB, IVL, ITGAL, CD44
23paraffin4510.3ELN, CD44, IVL, TIA1, GZMB, MLANA
24actinomycin d4510.3ELN, RARB, CD69, CD44, ITGAL
25genistein45 29 60 2 11 2415.3RARB, CD69, IL2RB, ELN, SRD5A1
26proline4510.3COL17A1, ELN, IL2RB, IVL, ITGAL
27cisplatin45 50 60 1113.3RARB, GZMB, ITGAL, CD44, IL2RB, AMBP
28chloramphenicol45 2 1112.3RARB, IVL, CD44, ELN
29aspartate4510.3ELN, IL2RB, AMBP
30arginine4510.2CD44, IL2RB, ELN, HMBS, RARB, GZMB
31lactate4510.2AMBP, GZMB, MLANA, IVL, IL2RB, ELN
32vegf4510.2ELN, SRD5A1, IL2RB, CD44, IVL, GZMB
33cyclosporin a45 29 6012.2AMBP, IL2RB, ITGAL, CD69, CD44, GZMB
34thymidine45 2411.2IVL, CD69, RARB, IL2RB, CD44
35hematoxylin4510.2MLANA, ELN, IVL
36estrogen4510.2RARB, CD44, IVL, S100A7, SRD5A1, GZMB
37nitric oxide45 11 2412.2GZMB, HMBS, IL2RB, ITGAL, CD44, CD69
38creatinine4510.1AMBP, ELN, CD44, CD69, IL2RB
39cysteine4510.1RARB, TYRP1, ITGAL, AMBP, GZMB, ELN
40oxygen45 2411.1CD44, GZMB, IL2RB, CD69, S100A7, ITGAL
41retinoid4510.1RARB, ELN, IL2RB, IVL
42alanine4510.1IL2RB, CD44, ITGAL, GZMB, AMBP, ELN
43lipid4510.0RARB, AMBP, ITGAL, IVL, CD44, GZMB
44serine4510.0GZMB, AMBP, COL17A1, IL2RB, IVL, TYRP1
45steroid459.9IL2RB, RARB, SRD5A1, GZMB, CD44, TYRP1
46retinoic acid45 2410.9CD44, AMBP, GZMB, ITGAL, IVL, IL2RB
47heparin45 29 11 2412.9ELN, CD44, GZMB, ITGAL, CD69
48betacarotene459.9ELN, RARB, IVL
49tyrosine459.9IVL, GZMB, HLA-DQB1, ITGAL, COL17A1, IL2RB
50calcium45 50 11 2412.7COL17A1, CD44, TYRP1, IVL, ITGAL, S100A7

GO Terms for genes affiliated with Lichen Sclerosus

Sources:
16Gene Ontology
See all sources

Cellular components related to Lichen Sclerosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.9COL17A1, MLANA, CD44, CD69, CD8A, IL2RB
2external side of plasma membraneGO:0098979.7ITGAL, CD44, CD69, CD8A, IL2RB

Molecular functions related to Lichen Sclerosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.3ELN, TIA1, AMBP, GZMB, S100A7, ITGAL

Products for genes affiliated with Lichen Sclerosus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lichen Sclerosus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet