MCID: LCH009
MIFTS: 41

Lichen Sclerosus malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Lichen Sclerosus

Aliases & Descriptions for Lichen Sclerosus:

Name: Lichen Sclerosus 50 52
Lichen Sclerosus Et Atrophicus 50 69
Lichen Sclerosis Et Atrophicus 50
Lichen Sclerosis 50

Characteristics:

HPO:

32
lichen sclerosus:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

ICD10 33 L90.0

Summaries for Lichen Sclerosus

NIH Rare Diseases : 50 lichen sclerosus is a chronic skin disorder that is more common in women, most often affecting the external part of the vagina (vulva) or the area around the anus. in men, it typically affects the tip of the penis. it can occur at any age but is usually seen in women over age 50. some people have no symptoms, while others may experience itchiness (sometimes severe), discomfort, or blistering. it often lasts for years and can cause permanent scarring. the underlying cause of lichen sclerosus is not fully understood but it is thought to relate to an autoimmune process. treatment may include topical steroids or other types of topical creams and/or surgery. last updated: 5/26/2015

MalaCards based summary : Lichen Sclerosus, also known as lichen sclerosus et atrophicus, is related to balanitis xerotica obliterans and squamous cell carcinoma, and has symptoms including squamous cell carcinoma An important gene associated with Lichen Sclerosus is ECM1 (Extracellular Matrix Protein 1), and among its related pathways/superpathways are Interferon gamma signaling and HTLV-I infection. The drugs Clobetasol and glucocorticoids have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast.

Wikipedia : 71 Lichen sclerosus (LS), and also known as lichen sclerosus et atrophicus (LSetA) [also termed,... more...

Related Diseases for Lichen Sclerosus

Diseases related to Lichen Sclerosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
id Related Disease Score Top Affiliating Genes
1 balanitis xerotica obliterans 11.9
2 squamous cell carcinoma 10.5
3 lichen planus 10.3
4 urethritis 10.3
5 balanitis 10.2
6 phimosis 10.2
7 apple allergy 10.2 HLA-DQB1 HLA-DRB1
8 hemoglobin d disease 10.2 HLA-DQB1 HLA-DRB1
9 bilateral parasagittal parieto-occipital polymicrogyria 10.2 HLA-DQB1 HLA-DRB1
10 immune deficiency, familial variable 10.2 HLA-DQB1 HLA-DRB1
11 lin-gettig syndrome 10.2 HLA-DQB1 HLA-DRB1
12 urethral stricture 10.2
13 midline interhemispheric variant of holoprosencephaly 10.2 HLA-DQB1 HLA-DRB1
14 autosomal dominant intermediate charcot-marie-tooth 10.2 HLA-DQB1 HLA-DRB1
15 renal agenesis meningomyelocele mullerian defect 10.2 HLA-DQB1 HLA-DRB1
16 lyme disease - neurological complications 10.2 HLA-DQB1 HLA-DRB1
17 distal trisomy 14q 10.2 HLA-DQB1 HLA-DRB1
18 learning disability 10.2 HLA-DQB1 HLA-DRB1
19 night blindness 10.2 HLA-DQB1 HLA-DRB1
20 cervical adenoid basal carcinoma 10.2 HLA-DQB1 HLA-DRB1
21 neonatal antiphospholipid syndrome 10.2 HLA-DQB1 HLA-DRB1
22 clostridium difficile colitis 10.2 HLA-DQB1 HLA-DRB1
23 myofibroma 10.2 HLA-DQB1 HLA-DRB1
24 oromandibular dystonia 10.2 HLA-DQB1 HLA-DRB1
25 cryptococcosis 10.1 HLA-DQB1 HLA-DRB1
26 bickerstaff brainstem encephalitis 10.1 HLA-DQB1 HLA-DRB1
27 periodontitis 1, juvenile 10.1 GZMB HLA-DRB1
28 familial acute necrotizing encephalopathy 10.1 GZMB HLA-DRB1
29 anaerobic meningitis 10.1 HLA-DQB1 HLA-DRB1
30 vulvar intraepithelial neoplasia 10.1
31 malignant glioma 10.1 GZMB TIA1
32 low anorectal malformation 10.1 HLA-DQB1 HLA-DRB1
33 alström syndrome 10.1 GZMB TIA1
34 malignant spindle cell melanoma 10.1 GZMB TP53
35 skeletal muscle cancer 10.1 GZMB TIA1
36 tibial adamantinoma 10.1 GZMB TIA1
37 superior limbic keratoconjunctivitis 10.1 GZMB TIA1
38 collagen type iii glomerulopathy 10.1 GZMB TIA1
39 ragweed sensitivity 10.1 HLA-DQB1 HLA-DRB1
40 fibrosclerosis of breast 10.1 GZMB TIA1
41 uterine ligament endometrioid adenocarcinoma 10.1 GZMB TIA1
42 congenital sucrase-isomaltase deficiency with starch and lactose intolerance 10.1 GZMB TIA1
43 macrogyria, pseudobulbar palsy and mental retardation 10.1 GZMB TIA1
44 melanoma 10.1
45 malignant teratoma 10.1 GZMB TIA1
46 cerebral lipidosis 10.1 GZMB TIA1
47 post-transplant lymphoproliferative disease 10.1 GZMB TIA1
48 barbiturate abuse 10.0 ELN HLA-DQB1
49 primary hyperoxaluria 10.0 CD44 TP53
50 childhood immature teratoma of ovary 10.0 GZMB TIA1

Graphical network of the top 20 diseases related to Lichen Sclerosus:



Diseases related to Lichen Sclerosus

Symptoms & Phenotypes for Lichen Sclerosus

Human phenotypes related to Lichen Sclerosus:

32
id Description HPO Frequency HPO Source Accession
1 squamous cell carcinoma 32 HP:0002860

Drugs & Therapeutics for Lichen Sclerosus

Drugs for Lichen Sclerosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clobetasol Phase 3,Phase 2 25122-46-7 32798 5311051
2 glucocorticoids Phase 3,Phase 2
3 Hormone Antagonists Phase 3,Phase 2
4 Hormones Phase 3,Phase 2
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
6 Anti-Inflammatory Agents Phase 3,Phase 2
7
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
8
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
9
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 6447131 17753757
10
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
11
Butyric Acid Experimental Phase 2 107-92-6 264
12 Analgesics Phase 2
13 Cortisol succinate Phase 2
14 Analgesics, Non-Narcotic Phase 2
15 Dermatologic Agents Phase 2
16 Peripheral Nervous System Agents Phase 2
17 Hydrocortisone 17-butyrate 21-propionate Phase 2
18 Hydrocortisone acetate Phase 2
19 Hydrocortisone-17-butyrate Phase 2
20 Immunosuppressive Agents Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 2
22 Antirheumatic Agents Phase 2
23 Calcineurin Inhibitors Phase 2
24 Antipruritics Phase 2
25 Progestins Phase 2
26
Cortisone acetate Approved 1950-04-4, 50-04-4 5745
27
Petrolatum Approved 8009-03-8
28
Triamcinolone Approved, Vet_approved 124-94-7 31307
29
Menthol Approved 2216-51-5 16666
30
Vitamin A Approved, Nutraceutical, Vet_approved 11103-57-4, 68-26-8 445354
31
Methylene blue Investigational 61-73-4
32
Cortisone 53-06-5 222786
33 Emollients
34 triamcinolone acetonide
35 Triamcinolone diacetate
36 Triamcinolone hexacetonide
37 Retinol palmitate
38 Estrogens
39 retinol Nutraceutical
40 Acidophilus Nutraceutical

Interventional clinical trials:

(show all 16)
id Name Status NCT ID Phase
1 Clobetasol Proprionate Versus Fractionated CO2 Laser for the Treatment of Lichen Sclerosus Recruiting NCT02573883 Phase 3
2 Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus Completed NCT00757874 Phase 2
3 Clobetasol Versus Pimecrolimus for Vulvar Lichen Sclerosus Completed NCT00393263 Phase 2
4 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2
5 Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus Terminated NCT01126255 Phase 2
6 Platelet Rich Plasma Injections for Vulvar Lichen Sclerosus Completed NCT02794363
7 Topical 0.05% Clobetasol Propionate in Vaseline Versus UVA-1 Phototherapy in Vulvar Lichen Sclerosus Completed NCT01400022
8 Vulvar Scarring Grading Scale for Lichen Sclerosus Recruiting NCT02880904
9 Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus Recruiting NCT03045172
10 Implication of Human Papillomavirus (HPV) in Lichen Physiopathology in Human (HPVLichen) Recruiting NCT02761122
11 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Recruiting NCT02732145
12 Vulvar Mucosal Specialty Clinic Chart Review Recruiting NCT02881229
13 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Recruiting NCT02223975
14 Circumcision Versus Preputioplasty for BXO in Children Recruiting NCT02854995
15 Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser Active, not recruiting NCT02416531
16 Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus Not yet recruiting NCT03063684

Search NIH Clinical Center for Lichen Sclerosus

Genetic Tests for Lichen Sclerosus

Anatomical Context for Lichen Sclerosus

MalaCards organs/tissues related to Lichen Sclerosus:

39
Skin, T Cells, Breast, Thyroid, Endothelial, Bone, Tongue

Publications for Lichen Sclerosus

Articles related to Lichen Sclerosus:

(show top 50) (show all 618)
id Title Authors Year
1
Intradermal injection of autologous platelet-rich plasma for the treatment of vulvar lichen sclerosus. ( 27986140 )
2017
2
Neurofibromatosis type 1 and lichen sclerosus: an uncommon association. ( 27978612 )
2017
3
Combined therapy in vulvar lichen sclerosus: does topical tretinoin improve the efficacy of mometasone furoate? ( 28024127 )
2017
4
Genital lichen sclerosus developing around 'ectopic' urethral orifices supports the role of occlusion and urine in its pathogenesis. ( 28081682 )
2017
5
Lichen Sclerosus in stable sexual partners: etiologic correlation or mere coincidence? ( 27978615 )
2017
6
Lichen sclerosus of the glans simulating melanoma. ( 28087029 )
2017
7
Clinical and dermoscopic changes of vulvar lichen sclerosus after topical corticosteroid treatment. ( 27075682 )
2016
8
A Unique Ocular Presentation of Extragenital Lichen Sclerosus. ( 26934564 )
2016
9
Current Practice Patterns Among Members of the American Urological Association for Male Genitourinary Lichen Sclerosus. ( 26948526 )
2016
10
Radiation-induced lichen sclerosus of the vulva : First report in the medical literature. ( 27832422 )
2016
11
Cornoid Lamellation Associated With Lichen Sclerosus. ( 26909590 )
2016
12
Oral Lichen Sclerosus: A Rare Case Report and Review of the Literature. ( 27807761 )
2016
13
Diversity of patient profile, urethral stricture, and other disease manifestations in a cohort of adult men with lichen sclerosus. ( 27195319 )
2016
14
NEVUS FLAMMEUS ASSOCIATED WITH DYSPLASTIC NEVI AND LICHEN SCLEROSUS: THE FIRST REPORT IN THE MEDICAL LITERATURE. ( 27001787 )
2016
15
A rare case of unilateral eosinophilic fasciitis associated with ipsilateral extragenital lichen sclerosus. ( 27730034 )
2016
16
Bleeding after circumcision is more likely in children with lichen sclerosus (balanitis xerotica obliterans). ( 28043767 )
2016
17
Transition from lichen sclerosus to squamous cell carcinoma in a single tissue section. ( 27163926 )
2016
18
Telangiectatic lichen sclerosus on the cheek successfully treated with topical tacrolimus. ( 27033557 )
2016
19
Lichen sclerosus et atrophicus in a surgical scar treated with fractional laser. ( 27911123 )
2016
20
Effects of Intravenous Ketamine Infusions in a Neuropathic Pain Patient with Lichen Sclerosus et Atrophicus. ( 27462225 )
2016
21
Lichen sclerosus associated with localized scleroderma: dermoscopy contribution. ( 27579757 )
2016
22
Pathological Investigation of Childhood Foreskin: Are Lichen Sclerosus and Phimosis Common? ( 26876402 )
2016
23
Histopathological and clinical traps in lichen sclerosus: a case report. ( 27833976 )
2016
24
Gorlin Syndrome, Vulvar Basal Cell Carcinomas, Vismodegib, and Lichen Sclerosus: From the ISSVD Case Consultation Committee. ( 27105331 )
2016
25
Lichen Sclerosus in a Patient With a History of Hereditary Nonpolyposis Colorectal Cancer. ( 26992266 )
2016
26
Evidence-based (S3) guideline on (anogenital) lichen sclerosus. JEADV. 2015; 29(10):e1-e43. ( 27230971 )
2016
27
Obesity-related male genital lichen sclerosus. ( 27891728 )
2016
28
Genital purpura as the presenting sign of lichen sclerosus. ( 27085248 )
2016
29
Polydeoxyribonucleotide Treatment in Genital Lichen Sclerosus in Males. ( 27618566 )
2016
30
New insights into potential risk factors and associations in genital lichen sclerosus: Data from a multicentre Italian study on 729 consecutive cases. ( 27515901 )
2016
31
Evidence-based (S3) Guideline on (anogenital) Lichen sclerosus. ( 27229264 )
2016
32
Folliculocentric Lichen Sclerosus et Atrophicus in a 10-Year-Old Girl. ( 27415635 )
2016
33
Recent advances in understanding urethral lichen sclerosus. ( 26918163 )
2016
34
Commentary to 'Bleeding after circumcision is more likely in children with Lichen sclerosus: "Facts are stubborn, but statistics are more pliable" '. ( 27989640 )
2016
35
Pediatric Lichen Sclerosus: A Review of the Literature and Management Recommendations. ( 27878062 )
2016
36
Female lichen sclerosus genitalis: discomfort and adaptation. ( 27598024 )
2016
37
PHOTODYNAMIC THERAPY WITH GREEN LIGHT FOR THE TREATMENT OF VULVAR LICHEN SCLEROSUS - PRELIMINARY RESULTS. ( 27919664 )
2016
38
Lichen Sclerosus-Presentation, Diagnosis and Management. ( 27232363 )
2016
39
The Prevalence of Lichen Sclerosus in Patients With Vulvar Squamous Cell Carcinoma. ( 27801760 )
2016
40
Lichen sclerosus of soft palate: A rare case report. ( 27166046 )
2016
41
Use of Platelet-rich Plasma for Vulvovaginal Autoimmune Conditions Like Lichen Sclerosus. ( 27975027 )
2016
42
Raman spectroscopy and multivariate analysis for the non invasive diagnosis of clinically inconclusive vulval lichen sclerosus. ( 27827479 )
2016
43
Treatment of long anterior urethral stricture associated to lichen sclerosus. ( 27816211 )
2016
44
EDF lichen sclerosus guideline. ( 27421964 )
2016
45
Response to commentary to 'Bleeding after circumcision is more likely in children with Lichen Sclerosus (Balanitis Xerotica Obliterans)'. ( 28089293 )
2016
46
Vulvar Melanoma Associated with Lichen Sclerosus in a Child: Case Report and Literature Review. ( 27040997 )
2016
47
Photodynamic therapy as a therapeutic alternative in vulvar lichen sclerosus: series of 8 cases. ( 27098754 )
2016
48
A Qualitative Study on Experiences After Vulvar Surgery in Women With Lichen Sclerosus and Sexual Pain. ( 27209180 )
2016
49
Nested Graft for Acral Lichen Sclerosus of the Feet: A Surgical Treatment for an Inflammatory Disease. ( 27257563 )
2016
50
Male genital lichen sclerosus in recipients of bone marrow transplants. ( 26936088 )
2016

Variations for Lichen Sclerosus

Expression for Lichen Sclerosus

Search GEO for disease gene expression data for Lichen Sclerosus.

Pathways for Lichen Sclerosus

GO Terms for Lichen Sclerosus

Cellular components related to Lichen Sclerosus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQB1 HLA-DRB1
2 transport vesicle membrane GO:0030658 9.26 HLA-DQB1 HLA-DRB1
3 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
5 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Lichen Sclerosus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation GO:0019882 9.4 HLA-DQB1 HLA-DRB1
2 protein tetramerization GO:0051262 9.37 HLA-DRB1 TP53
3 interferon-gamma-mediated signaling pathway GO:0060333 9.33 CD44 HLA-DQB1 HLA-DRB1
4 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.32 GZMB TP53
5 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DQB1 HLA-DRB1
6 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
7 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Lichen Sclerosus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Lichen Sclerosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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