LCDD
MCID: LGH004
MIFTS: 30

Light Chain Deposition Disease (LCDD) malady

Nephrological diseases, Blood diseases, Cancer diseases categories

Summaries for Light Chain Deposition Disease

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Light chain deposition disease involves our immune system. it is caused by an excess buildup of immunoglobulin light chain in our tissues and organs. immunoglobulins, also known as antibodies, are special proteins made by immune cells. while an important part of our immune system, if these proteins become trapped in the tissues of the kidneys, lungs, skin, joints, or blood vessels, they can set off reactions that lead to tissue or organ inflammation (swelling) and damage. early signs and symptoms of light chain deposition disease may include protein in the urine, high blood pressure, decreased kidney function, and nephrotic syndrome. light chain deposition disease is often associated with multiple myeloma, monoclonal gammopathy of undetermined significance, or other disorders of abnormal overgrowth of lymph nodes. last updated: 4/2/2010

MalaCards: Light Chain Deposition Disease, also known as light-chain deposition disease, is related to amyloidosis and myeloma. An important gene associated with Light Chain Deposition Disease is CD14 (CD14 molecule), and among its related pathways are Classical antibody-mediated complement activation and Fc epsilon receptor (FCERI) signaling. The compounds latex and alpha-naphthyl acetate have been mentioned in the context of this disorder. Affiliated tissues include kidney, lymph node and lung.

Wikipedia:63 Light chain deposition disease (LCDD) is a rare blood cell disease which is characterized by deposition... more...

Aliases & Classifications for Light Chain Deposition Disease

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42NIH Rare Diseases, 48Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Related Diseases for Light Chain Deposition Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Light Chain Deposition Disease:



Diseases related to light chain deposition disease

Clinical Features for Light Chain Deposition Disease

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Drugs & Therapeutics for Light Chain Deposition Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Light Chain Deposition Disease

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Anatomical Context for Light Chain Deposition Disease

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32MalaCards
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MalaCards organs/tissues related to Light Chain Deposition Disease:

32
Kidney, Lymph node, Lung, Skin

Animal Models for Light Chain Deposition Disease or affiliated genes

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Publications for Light Chain Deposition Disease

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Genetic Variations for Light Chain Deposition Disease

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Expression for genes affiliated with Light Chain Deposition Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Light Chain Deposition Disease

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Pathways for genes affiliated with Light Chain Deposition Disease

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53Reactome
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Compounds for genes affiliated with Light Chain Deposition Disease

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44Novoseek
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Compounds related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1latex449.1CD14, CD68
2alpha-naphthyl acetate448.8CD14, CD68

GO Terms for genes affiliated with Light Chain Deposition Disease

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16Gene Ontology
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Cellular components related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:0100089.0CD14, CD68
2extracellular regionGO:0055768.8CD14, IGKV1-5, IGKC
3plasma membraneGO:0058867.7CD14, CD68, IGKV1-5, IGKC

Biological processes related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement activationGO:0069569.4IGKV1-5, IGKC
2complement activation, classical pathwayGO:0069589.4IGKV1-5, IGKC
3Fc-epsilon receptor signaling pathwayGO:0380959.3IGKV1-5, IGKC
4Fc-gamma receptor signaling pathway involved in phagocytosisGO:0380969.2IGKV1-5, IGKC
5regulation of immune responseGO:0507769.0IGKV1-5, IGKC
6innate immune responseGO:0450878.8IGKC, IGKV1-5, CD14

Molecular functions related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:0038239.3IGKV1-5, IGKC

Products for genes affiliated with Light Chain Deposition Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Light Chain Deposition Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet