LCDD
MCID: LGH004
MIFTS: 35

Light Chain Deposition Disease (LCDD) malady

Rare diseases, Nephrological diseases, Blood diseases, Cancer diseases categories
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Summaries for Light Chain Deposition Disease

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NIH Rare Diseases:42 Light chain deposition disease involves our immune system. it is caused by an excess buildup of immunoglobulin light chain in our tissues and organs. immunoglobulins, also known as antibodies, are special proteins made by immune cells. while an important part of our immune system, if these proteins become trapped in the tissues of the kidneys, lungs, skin, joints, or blood vessels, they can set off reactions that lead to tissue or organ inflammation (swelling) and damage. early signs and symptoms of light chain deposition disease may include protein in the urine, high blood pressure, decreased kidney function, and nephrotic syndrome. light chain deposition disease is often associated with multiple myeloma, monoclonal gammopathy of undetermined significance, or other disorders of abnormal overgrowth of lymph nodes. last updated: 4/2/2010

MalaCards based summary: Light Chain Deposition Disease, also known as light-chain deposition disease, is related to amyloidosis and myeloma. An important gene associated with Light Chain Deposition Disease is IGKV1-5 (immunoglobulin kappa variable 1-5), and among its related pathways are Downstream Signaling Events Of B Cell Receptor (BCR) and PI-3K cascade. Affiliated tissues include kidney, lung and lymph node.

Wikipedia:65 Light chain deposition disease (LCDD) is a rare blood cell disease which is characterized by deposition... more...

Aliases & Classifications for Light Chain Deposition Disease

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Sources:
42NIH Rare Diseases, 48Orphanet, 62UMLS, 26ICD10 via Orphanet
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Related Diseases for Light Chain Deposition Disease

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Graphical network of the top 20 diseases related to Light Chain Deposition Disease:



Diseases related to light chain deposition disease

Symptoms for Light Chain Deposition Disease

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Drugs & Therapeutics for Light Chain Deposition Disease

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Drug clinical trials:

Search ClinicalTrials for Light Chain Deposition Disease

Search NIH Clinical Center for Light Chain Deposition Disease

Genetic Tests for Light Chain Deposition Disease

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Anatomical Context for Light Chain Deposition Disease

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MalaCards organs/tissues related to Light Chain Deposition Disease:

32
Kidney, Lung, Lymph node, Skin, Liver, B cells, Spleen, Brain, Heart

Animal Models for Light Chain Deposition Disease or affiliated genes

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Publications for Light Chain Deposition Disease

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Articles related to Light Chain Deposition Disease:

(show top 50)    (show all 133)
idTitleAuthorsYear
1
Isolated intracerebral light chain deposition disease: novel imaging and pathologic findings. (25084689)
2014
2
Late recurrence of light chain deposition disease after kidney transplantation treated with bortezomib: a case report. (25249814)
2014
3
Hypertension, renal failure, and edema in a 38-year-old man: light chain deposition disease; a case report and review of the literature. (24772399)
2014
4
Portal hypertension related to light chain deposition disease of liver: an enlightening experience. (23723105)
2013
5
Sudden death possibly related to lenalidomide given for cardiac and muscle AL amyloidosis secondary to light chain deposition disease. (22504167)
2013
6
Retinal pigment epithelial detachments and tears, and progressive retinal degeneration in light chain deposition disease. (23385633)
2013
7
Primary cerebral low-grade B-cell lymphoma, monoclonal immunoglobulin deposition disease, cerebral light chain deposition disease and "aggregoma": an update on classification and diagnosis. (23947787)
2013
8
Bortezomib/dexamethasone followed by autologous stem cell transplantation as front line treatment for light-chain deposition disease. (22690902)
2012
9
Light chain deposition disease: novel biological insights and treatment advances. (22471811)
2012
10
Light chain deposition disease in a postrenal transplant patient. (23087561)
2012
11
Light chain deposition disease presenting as cholestatic jaundice: a case report. (22359728)
2012
12
Autologous stem cell transplant for light chain deposition disease: incorporating bortezomib to the induction therapy. (22641434)
2012
13
Expanding the spectrum of monoclonal light chain deposition disease in muscle. (22499107)
2012
14
Light-chain deposition disease of the kidney: a case report. (22471437)
2012
15
Case report: a case of light chain deposition disease involving liver and stomach with chronic hepatitis C virus infection and hepatocellular carcinoma. (21412789)
2011
16
Cerebral low-grade lymphoma and light chain deposition disease: exceedingly high IgG levels in the cerebrospinal fluid as a diagnostic clue. (21073842)
2010
17
Light chain deposition disease presenting as massive hepatomegaly. (20350234)
2010
18
Development of rapid light-chain deposition disease in hepatic arteries with severe ischemic cholangitis in a multiple myeloma patient treated with melphalan, prednisone and lenalidomide. (19101782)
2009
19
Evolution of light chain deposition disease over 8 years. (19863884)
2009
20
Treatment of light chain deposition disease with bortezomib and dexamethasone. (19066331)
2009
21
Progressive renal failure as the first manifestation of monoclonal light-chain deposition disease with rapid multiple organ involvement. (19281743)
2009
22
Pathomechanisms of cyst formation in pulmonary light chain deposition disease. (18978139)
2008
23
Light chain deposition disease after renal transplantation. (18554763)
2008
24
Charge differences between in vivo deposits in immunoglobulin light chain amyloidosis and non-amyloid light chain deposition disease. (17223908)
2007
25
Pulmonary cystic disorder related to light chain deposition disease. (16399989)
2006
26
Diagnosis and monitoring a case of light-chain deposition disease in the kidney using a new, sensitive immunoassay. (15784642)
2005
27
Expanding the pathologic spectrum of light chain deposition disease: a rare variant with clinical follow-up of 7 years. (15696120)
2005
28
Lambda light chain deposition disease in a renal allograft. (16387099)
2005
29
Low-density lipoprotein apheresis in a patient with arteriosclerosis obliterans and light chain deposition disease. (15224807)
2004
30
AL-amyloidosis and light-chain deposition disease light chains induce divergent phenotypic transformations of human mesangial cells. (15286662)
2004
31
Metachronous development of nonamyloidogenic [lambda] light chain deposition disease and IgG heavy chain amyloidosis in the same patient. (14576484)
2003
32
Light chain deposition disease with renal involvement: clinical characteristics and prognostic factors. (14655186)
2003
33
Reversible restrictive cardiomyopathy due to light-chain deposition disease. (11838655)
2002
34
Light chain deposition disease of the liver without renal involvement in a patient with multiple myeloma related to liver failure and rapid fatal outcome. (11991600)
2002
35
Congestive heart failure: revealing light chain deposition disease. (10745155)
2000
36
Hepatic amyloidosis with light chain deposition disease. A rare association. (11215561)
2000
37
A patient with multiple myeloma, amyloidosis and light-chain deposition disease in kidneys with a long survival. (10436302)
1999
38
Light chain deposition disease in multiple myeloma: MR imaging features correlated with histopathological findings. (9554011)
1998
39
Light chain deposition disease detected by antisera to a variable region of the kappa1 light chain subgroup. (9736813)
1998
40
Light chain deposition disease complicating familial Mediterranean fever. (9186082)
1997
41
Structural peculiarities of a truncated V kappa III immunoglobulin light chain in myeloma with light chain deposition disease. (8918585)
1996
42
Renal disease and patient survival in light chain deposition disease. (7634543)
1995
43
Pathogenesis of glomerulosclerosis in light chain deposition disease. Role for transforming growth factor-beta. (7639331)
1995
44
Light chain deposition disease (nodular glomerulopathy, kappa light chain deposition disease): a case report. (8191617)
1994
45
Light chain deposition disease of the kidney. Morphological aspects in 24 patients. (7812513)
1994
46
Primary structure of a monoclonal kappa chain in myeloma with light chain deposition disease. (1733627)
1992
47
Structure of a monoclonal kappa chain of the V kappa IV subgroup in the kidney and plasma cells in light chain deposition disease. (1904072)
1991
48
An autopsy case of diffuse myelomatosis associated with systemic kappa light chain deposition disease (LCDD). A patho-anatomical, immunohistochemical and immunobiochemical study. (3135702)
1988
49
Association of systemic light-chain deposition disease and amyloidosis: a report of three patients with renal involvement. (3930115)
1985
50
Light-chain deposition disease: its relation with AL-type amyloidosis. (6434789)
1984

Variations for Light Chain Deposition Disease

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Expression for genes affiliated with Light Chain Deposition Disease

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Expression patterns in normal tissues for genes affiliated with Light Chain Deposition Disease

Search GEO for disease gene expression data for Light Chain Deposition Disease.

Pathways for genes affiliated with Light Chain Deposition Disease

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Pathways related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IGKC, IGKV1-5
2
Show member pathways
9.1IGKV1-5, IGKC
3
Show member pathways
9.1IGKC, IGKV1-5
4
Show member pathways
9.1IGKC, IGKV1-5
5
Show member pathways
9.1IGKV1-5, IGKC
6
Show member pathways
9.1IGKC, IGKV1-5
79.1IGKC, IGKV1-5
8
Show member pathways
9.1IGKC, IGKV1-5

Compounds for genes affiliated with Light Chain Deposition Disease

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GO Terms for genes affiliated with Light Chain Deposition Disease

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Cellular components related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.1IGKC, IGKV1-5
2blood microparticleGO:0725628.8IGKC, IGKV1-5

Biological processes related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1complement activationGO:0069569.3IGKC, IGKV1-5
2complement activation, classical pathwayGO:0069589.2IGKC, IGKV1-5
3Fc-gamma receptor signaling pathway involved in phagocytosisGO:0380969.2IGKV1-5, IGKC
4regulation of immune responseGO:0507769.1IGKV1-5, IGKC
5innate immune responseGO:0450879.1IGKC, IGKV1-5
6Fc-epsilon receptor signaling pathwayGO:0380959.0IGKV1-5, IGKC
7immune responseGO:0069558.8IGKV1-5, IGKC

Molecular functions related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:0038239.1IGKC, IGKV1-5

Products for genes affiliated with Light Chain Deposition Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Light Chain Deposition Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet