LCDD
MCID: LGH004
MIFTS: 36

Light Chain Deposition Disease (LCDD) malady

Rare diseases, Nephrological diseases, Blood diseases, Cancer diseases categories

Summaries for Light Chain Deposition Disease

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Sources:
44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Light chain deposition disease involves our immune system. it is caused by an excess buildup of immunoglobulin light chain in our tissues and organs. immunoglobulins, also known as antibodies, are special proteins made by immune cells. while an important part of our immune system, if these proteins become trapped in the tissues of the kidneys, lungs, skin, joints, or blood vessels, they can set off reactions that lead to tissue or organ inflammation (swelling) and damage. early signs and symptoms of light chain deposition disease may include protein in the urine, high blood pressure, decreased kidney function, and nephrotic syndrome. light chain deposition disease is often associated with multiple myeloma, monoclonal gammopathy of undetermined significance, or other disorders of abnormal overgrowth of lymph nodes. last updated: 4/2/2010

MalaCards: Light Chain Deposition Disease, also known as light-chain deposition disease, is related to amyloidosis and myeloma. An important gene associated with Light Chain Deposition Disease is IGKV1-5 (immunoglobulin kappa variable 1-5), and among its related pathways are Downstream Signaling Events Of B Cell Receptor (BCR) and PI-3K cascade. Affiliated tissues include kidney, lung and skin.

Wikipedia:66 Light chain deposition disease (LCDD) is a rare blood cell disease which is characterized by deposition... more...

Aliases & Classifications for Light Chain Deposition Disease

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Sources:
44NIH Rare Diseases, 50Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet
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Related Diseases for Light Chain Deposition Disease

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Light Chain Deposition Disease:



Diseases related to light chain deposition disease

Symptoms for Light Chain Deposition Disease

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Drugs & Therapeutics for Light Chain Deposition Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Light Chain Deposition Disease

Search CenterWatch for Light Chain Deposition Disease

Genetic Tests for Light Chain Deposition Disease

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Anatomical Context for Light Chain Deposition Disease

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34MalaCards
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MalaCards organs/tissues related to Light Chain Deposition Disease:

34
Kidney, Lung, Skin, Lymph node, Liver, B cells, Brain, Spleen, Heart

Animal Models for Light Chain Deposition Disease or affiliated genes

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Publications for Light Chain Deposition Disease

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53PubMed
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Articles related to Light Chain Deposition Disease:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
Portal hypertension related to light chain deposition disease of liver: an enlightening experience. (23723105)
2013
2
Sudden death possibly related to lenalidomide given for cardiac and muscle AL amyloidosis secondary to light chain deposition disease. (22504167)
2013
3
Retinal pigment epithelial detachments and tears, and progressive retinal degeneration in light chain deposition disease. (23385633)
2013
4
Primary cerebral low-grade B-cell lymphoma, monoclonal immunoglobulin deposition disease, cerebral light chain deposition disease and "aggregoma": an update on classification and diagnosis. (23947787)
2013
5
Retinal haemorrhage, subretinal pigment epithelial deposits and serous macular detachment in light chain deposition disease. (23853165)
2013
6
Bortezomib/dexamethasone followed by autologous stem cell transplantation as front line treatment for light-chain deposition disease. (22690902)
2012
7
Light chain deposition disease: novel biological insights and treatment advances. (22471811)
2012
8
Light chain deposition disease in a postrenal transplant patient. (23087561)
2012
9
Light chain deposition disease presenting as cholestatic jaundice: a case report. (22359728)
2012
10
Autologous stem cell transplant for light chain deposition disease: incorporating bortezomib to the induction therapy. (22641434)
2012
11
Expanding the spectrum of monoclonal light chain deposition disease in muscle. (22499107)
2012
12
Light-chain deposition disease of the kidney: a case report. (22471437)
2012
13
Case report: a case of light chain deposition disease involving liver and stomach with chronic hepatitis C virus infection and hepatocellular carcinoma. (21412789)
2011
14
Cerebral low-grade lymphoma and light chain deposition disease: exceedingly high IgG levels in the cerebrospinal fluid as a diagnostic clue. (21073842)
2010
15
Light chain deposition disease presenting as massive hepatomegaly. (20350234)
2010
16
Development of rapid light-chain deposition disease in hepatic arteries with severe ischemic cholangitis in a multiple myeloma patient treated with melphalan, prednisone and lenalidomide. (19101782)
2009
17
Evolution of light chain deposition disease over 8 years. (19863884)
2009
18
Treatment of light chain deposition disease with bortezomib and dexamethasone. (19066331)
2009
19
Progressive renal failure as the first manifestation of monoclonal light-chain deposition disease with rapid multiple organ involvement. (19281743)
2009
20
Pathomechanisms of cyst formation in pulmonary light chain deposition disease. (18978139)
2008
21
Light chain deposition disease after renal transplantation. (18554763)
2008
22
Pulmonary cystic disorder related to light chain deposition disease. (16399989)
2006
23
Diagnosis and monitoring a case of light-chain deposition disease in the kidney using a new, sensitive immunoassay. (15784642)
2005
24
Expanding the pathologic spectrum of light chain deposition disease: a rare variant with clinical follow-up of 7 years. (15696120)
2005
25
Lambda light chain deposition disease in a renal allograft. (16387099)
2005
26
Low-density lipoprotein apheresis in a patient with arteriosclerosis obliterans and light chain deposition disease. (15224807)
2004
27
AL-amyloidosis and light-chain deposition disease light chains induce divergent phenotypic transformations of human mesangial cells. (15286662)
2004
28
Metachronous development of nonamyloidogenic [lambda] light chain deposition disease and IgG heavy chain amyloidosis in the same patient. (14576484)
2003
29
Light chain deposition disease with renal involvement: clinical characteristics and prognostic factors. (14655186)
2003
30
Reversible restrictive cardiomyopathy due to light-chain deposition disease. (11838655)
2002
31
Light chain deposition disease of the liver without renal involvement in a patient with multiple myeloma related to liver failure and rapid fatal outcome. (11991600)
2002
32
Congestive heart failure: revealing light chain deposition disease. (10745155)
2000
33
Hepatic amyloidosis with light chain deposition disease. A rare association. (11215561)
2000
34
A patient with multiple myeloma, amyloidosis and light-chain deposition disease in kidneys with a long survival. (10436302)
1999
35
Light chain deposition disease in multiple myeloma: MR imaging features correlated with histopathological findings. (9554011)
1998
36
Light chain deposition disease detected by antisera to a variable region of the kappa1 light chain subgroup. (9736813)
1998
37
Light chain deposition disease complicating familial Mediterranean fever. (9186082)
1997
38
Structural peculiarities of a truncated V kappa III immunoglobulin light chain in myeloma with light chain deposition disease. (8918585)
1996
39
Renal disease and patient survival in light chain deposition disease. (7634543)
1995
40
Pathogenesis of glomerulosclerosis in light chain deposition disease. Role for transforming growth factor-beta. (7639331)
1995
41
Role of light chain variable region in myeloma with light chain deposition disease: evidence from an experimental model. (7579330)
1995
42
Light chain deposition disease (nodular glomerulopathy, kappa light chain deposition disease): a case report. (8191617)
1994
43
Light chain deposition disease of the kidney. Morphological aspects in 24 patients. (7812513)
1994
44
Primary structure of a monoclonal kappa chain in myeloma with light chain deposition disease. (1733627)
1992
45
Structure of a monoclonal kappa chain of the V kappa IV subgroup in the kidney and plasma cells in light chain deposition disease. (1904072)
1991
46
Light chain deposition disease without detectable light chains in serum or urine. Report of a case and review of the literature. (1791875)
1991
47
An autopsy case of diffuse myelomatosis associated with systemic kappa light chain deposition disease (LCDD). A patho-anatomical, immunohistochemical and immunobiochemical study. (3135702)
1988
48
Association of systemic light-chain deposition disease and amyloidosis: a report of three patients with renal involvement. (3930115)
1985
49
Glomerular matrix proteins in nodular glomerulosclerosis in association with light chain deposition disease and diabetes mellitus. (3921452)
1985
50
Light-chain deposition disease: its relation with AL-type amyloidosis. (6434789)
1984

Variations for Light Chain Deposition Disease

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Expression for genes affiliated with Light Chain Deposition Disease

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Light Chain Deposition Disease

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Pathways for genes affiliated with Light Chain Deposition Disease

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Sources:
51PathCards, 56Reactome, 31KEGG, 54QIAGEN
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Pathways related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IGKC, IGKV1-5
2
Show member pathways
9.1IGKC, IGKV1-5
3
Show member pathways
9.1IGKC, IGKV1-5
4
Show member pathways
9.1IGKV1-5, IGKC
5
Show member pathways
9.1IGKC, IGKV1-5
6
Show member pathways
9.1IGKC, IGKV1-5
79.1IGKC, IGKV1-5
8
Show member pathways
9.1IGKC, IGKV1-5

Compounds for genes affiliated with Light Chain Deposition Disease

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GO Terms for genes affiliated with Light Chain Deposition Disease

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17Gene Ontology
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Cellular components related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.1IGKC, IGKV1-5
2blood microparticleGO:0725628.8IGKC, IGKV1-5

Biological processes related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1complement activationGO:0069569.3IGKC, IGKV1-5
2complement activation, classical pathwayGO:0069589.2IGKC, IGKV1-5
3Fc-gamma receptor signaling pathway involved in phagocytosisGO:0380969.2IGKC, IGKV1-5
4regulation of immune responseGO:0507769.1IGKV1-5, IGKC
5innate immune responseGO:0450879.1IGKC, IGKV1-5
6Fc-epsilon receptor signaling pathwayGO:0380959.0IGKC, IGKV1-5
7immune responseGO:0069558.8IGKC, IGKV1-5

Molecular functions related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:0038239.1IGKC, IGKV1-5

Products for genes affiliated with Light Chain Deposition Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Light Chain Deposition Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet