Light Chain Deposition Disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Light Chain Deposition Disease

Sources:
⁴²NIH Rare Diseases, ⁶⁴Wikipedia, ³²MalaCards
See all sources

NIH Rare Diseases:⁴² Light chain deposition disease involves our immune system. it is caused by an excess buildup of immunoglobulin light chain in our tissues and organs. immunoglobulins, also known as antibodies, are special proteins made by immune cells. while an important part of our immune system, if these proteins become trapped in the tissues of the kidneys, lungs, skin, joints, or blood vessels, they can set off reactions that lead to tissue or organ inflammation (swelling) and damage. early signs and symptoms of light chain deposition disease may include protein in the urine, high blood pressure, decreased kidney function, and nephrotic syndrome. light chain deposition disease is often associated with multiple myeloma, monoclonal gammopathy of undetermined significance, or other disorders of abnormal overgrowth of lymph nodes. last updated: 4/2/2010

MalaCards based summary: Light Chain Deposition Disease, also known as light-chain deposition disease, is related to amyloidosis and myeloma. An important gene associated with Light Chain Deposition Disease is IGKV1-5 (immunoglobulin kappa variable 1-5), and among its related pathways are Downstream Signaling Events Of B Cell Receptor (BCR) and PI-3K cascade. Affiliated tissues include kidney, lung and lymph node.

Wikipedia:⁶⁴ Light chain deposition disease (LCDD) is a rare blood cell disease which is characterized by deposition... more...

Aliases & Classifications for Light Chain Deposition Disease

Sources:
⁴²NIH Rare Diseases, ⁴⁸Orphanet, ⁶¹UMLS, ²⁷ICD10 via Orphanet
See all sources

Light Chain Deposition Disease, Aliases & Descriptions:

Name: Light Chain Deposition Disease ⁴² ⁴⁸ ⁶¹

Light-Chain Deposition Disease ⁴²

Lcdd ⁴⁸

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Nephrological diseases, Blood diseases

ICD10: ²⁷

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Certain disorders involving the immune mechanism

Other disorders involving the immune mechanism, not elsewhere classified

Other specified disorders involving the immune mechanism, not elsewhere classified

Orphanet: ⁴⁸

Rare renal diseases

Rare haematological diseases

Rare tumors

External Ids:

ICD10 via Orphanet²⁷ D89.8

Related Diseases for Light Chain Deposition Disease

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Light Chain Deposition Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 39)

id	Related Disease	Score
1	amyloidosis	10.8
2	myeloma	10.8
3	multiple myeloma	10.7
4	hepatitis	10.5
5	retinitis	10.5
6	hypertension	10.4
7	glomerulosclerosis	10.4
8	al amyloidosis	10.4
9	portal hypertension	10.4
10	cerebritis	10.4
11	restrictive cardiomyopathy	10.4
12	light and heavy chain deposition disease	10.4
13	heavy chain deposition disease	10.4
14	arthritis	10.2
15	b-cell lymphomas	10.2
16	congestive heart failure	10.2
17	diabetes mellitus	10.2
18	hepatocellular carcinoma	10.2
19	rheumatoid arthritis	10.2
20	familial mediterranean fever	10.2
21	poems syndrome	10.2
22	hepatitis c	10.2
23	arteriosclerosis obliterans	10.2
24	macroglobulinemia	10.2
25	arteriosclerosis	10.2
26	arthropathy	10.2
27	cholangitis	10.2
28	cholestasis	10.2
29	histiocytosis	10.2
30	neuropathy	10.2
31	pancreatitis	10.2
32	proteinuria	10.2
33	retinal degeneration	10.2
34	retinal detachment	10.2
35	amyloid neuropathy	10.2
36	sea-blue histiocytosis	10.2
37	amyloidosis, secondary	10.2
38	hepatitis c virus	10.2
39	immunotactoid glomerulopathy	10.1

Graphical network of the top 20 diseases related to Light Chain Deposition Disease:

Symptoms for Light Chain Deposition Disease

Drugs & Therapeutics for Light Chain Deposition Disease

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Light Chain Deposition Disease

Search NIH Clinical Center for Light Chain Deposition Disease

Genetic Tests for Light Chain Deposition Disease

Anatomical Context for Light Chain Deposition Disease

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Light Chain Deposition Disease:

³²

Kidney, Lung, Lymph node, Skin, Liver, B cells, Spleen, Brain, Heart

Animal Models for Light Chain Deposition Disease or affiliated genes

Publications for Light Chain Deposition Disease

Sources:
⁵¹PubMed
See all sources

Articles related to Light Chain Deposition Disease:

(show top 50) (show all 133)

id	Title	Authors	Year
1	Isolated intracerebral light chain deposition disease: novel imaging and pathologic findings. (25084689)	Yu J.P.... Glastonbury C.M.	2014
2	Late recurrence of light chain deposition disease after kidney transplantation treated with bortezomib: a case report. (25249814)	Moiz A.... Paueksakon P.	2014
3	Hypertension, renal failure, and edema in a 38-year-old man: light chain deposition disease; a case report and review of the literature. (24772399)	SAID S.... T Hernandez G.	2014
4	Portal hypertension related to light chain deposition disease of liver: an enlightening experience. (23723105)	Talukdar A.... Saha M.	2013
5	Sudden death possibly related to lenalidomide given for cardiac and muscle AL amyloidosis secondary to light chain deposition disease. (22504167)	Finsterer J.... Regele H.	2013
6	Retinal pigment epithelial detachments and tears, and progressive retinal degeneration in light chain deposition disease. (23385633)	Spielberg L.H.... Leys A.M.	2013
7	Primary cerebral low-grade B-cell lymphoma, monoclonal immunoglobulin deposition disease, cerebral light chain deposition disease and "aggregoma": an update on classification and diagnosis. (23947787)	Skardelly M.... Ritz R.	2013
8	Bortezomib/dexamethasone followed by autologous stem cell transplantation as front line treatment for light-chain deposition disease. (22690902)	Tovar N.... BladAc J.	2012
9	Light chain deposition disease: novel biological insights and treatment advances. (22471811)	Jimenez-Zepeda V.H.	2012
10	Light chain deposition disease in a postrenal transplant patient. (23087561)	Mittal N.... Joshi K.	2012
11	Light chain deposition disease presenting as cholestatic jaundice: a case report. (22359728)	Kumar P.N.... .	2012
12	Autologous stem cell transplant for light chain deposition disease: incorporating bortezomib to the induction therapy. (22641434)	Jimenez-Zepeda V.H.... Kukreti V.	2012
13	Expanding the spectrum of monoclonal light chain deposition disease in muscle. (22499107)	Ostrow L.W.... Mammen A.L.	2012
14	Light-chain deposition disease of the kidney: a case report. (22471437)	Darouich S.... Maiz H.B.	2012
15	Case report: a case of light chain deposition disease involving liver and stomach with chronic hepatitis C virus infection and hepatocellular carcinoma. (21412789)	Kwon J.H.... Song S.H.	2011
16	Cerebral low-grade lymphoma and light chain deposition disease: exceedingly high IgG levels in the cerebrospinal fluid as a diagnostic clue. (21073842)	Pantazis G.... Bornemann A.	2010
17	Light chain deposition disease presenting as massive hepatomegaly. (20350234)	Nath S.V.... Prince H.M.	2010
18	Development of rapid light-chain deposition disease in hepatic arteries with severe ischemic cholangitis in a multiple myeloma patient treated with melphalan, prednisone and lenalidomide. (19101782)	Weisel K.C.... Kanz L.	2009
19	Evolution of light chain deposition disease over 8 years. (19863884)	Gerth J.... Wolf G.	2009
20	Treatment of light chain deposition disease with bortezomib and dexamethasone. (19066331)	Kastritis E.... Dimopoulos M.A.	2009
21	Progressive renal failure as the first manifestation of monoclonal light-chain deposition disease with rapid multiple organ involvement. (19281743)	PAcrez-SuA!rez G.... HernA!ndez D.	2009
22	Pathomechanisms of cyst formation in pulmonary light chain deposition disease. (18978139)	Colombat M.... Birembaut P.	2008
23	Light chain deposition disease after renal transplantation. (18554763)	Taneda S.... Yamaguchi Y.	2008
24	Charge differences between in vivo deposits in immunoglobulin light chain amyloidosis and non-amyloid light chain deposition disease. (17223908)	Kaplan B.... Gallo G.	2007
25	Pulmonary cystic disorder related to light chain deposition disease. (16399989)	Colombat M.... Danel C.	2006
26	Diagnosis and monitoring a case of light-chain deposition disease in the kidney using a new, sensitive immunoassay. (15784642)	Brockhurst I.... Chapman C.S.	2005
27	Expanding the pathologic spectrum of light chain deposition disease: a rare variant with clinical follow-up of 7 years. (15696120)	Chang A.... Alpers C.E.	2005
28	Lambda light chain deposition disease in a renal allograft. (16387099)	Tanenbaum N.D.... Spurney R.F.	2005
29	Low-density lipoprotein apheresis in a patient with arteriosclerosis obliterans and light chain deposition disease. (15224807)	Nakamura T.... Koide H.	2004
30	AL-amyloidosis and light-chain deposition disease light chains induce divergent phenotypic transformations of human mesangial cells. (15286662)	Keeling J.... Herrera G.A.	2004
31	Metachronous development of nonamyloidogenic [lambda] light chain deposition disease and IgG heavy chain amyloidosis in the same patient. (14576484)	Copeland J.N.... Nadasdy T.	2003
32	Light chain deposition disease with renal involvement: clinical characteristics and prognostic factors. (14655186)	Pozzi C.... Locatelli F.	2003
33	Reversible restrictive cardiomyopathy due to light-chain deposition disease. (11838655)	Nakamura M.... Hiramori K.	2002
34	Light chain deposition disease of the liver without renal involvement in a patient with multiple myeloma related to liver failure and rapid fatal outcome. (11991600)	Michopoulos S.... Dimopoulos M.A.	2002
35	Congestive heart failure: revealing light chain deposition disease. (10745155)	Jego P.... Grosbois B.	2000
36	Hepatic amyloidosis with light chain deposition disease. A rare association. (11215561)	Casiraghi M.A.... Beretta R.	2000
37	A patient with multiple myeloma, amyloidosis and light-chain deposition disease in kidneys with a long survival. (10436302)	Christou L.... Bourantas K.L.	1999
38	Light chain deposition disease in multiple myeloma: MR imaging features correlated with histopathological findings. (9554011)	Baur A.... Reiser M.	1998
39	Light chain deposition disease detected by antisera to a variable region of the kappa1 light chain subgroup. (9736813)	Takeda S.... Hoshii Y.	1998
40	Light chain deposition disease complicating familial Mediterranean fever. (9186082)	Vella J.P.... Walshe J.J.	1997
41	Structural peculiarities of a truncated V kappa III immunoglobulin light chain in myeloma with light chain deposition disease. (8918585)	Decourt C.... Rocca A.	1996
42	Renal disease and patient survival in light chain deposition disease. (7634543)	Pozzi C.... Locatelli F.	1995
43	Pathogenesis of glomerulosclerosis in light chain deposition disease. Role for transforming growth factor-beta. (7639331)	Zhu L.... Sanders P.W.	1995
44	Light chain deposition disease (nodular glomerulopathy, kappa light chain deposition disease): a case report. (8191617)	Herrera G.A.	1994
45	Light chain deposition disease of the kidney. Morphological aspects in 24 patients. (7812513)	StrA... Mihatsch M.J.	1994
46	Primary structure of a monoclonal kappa chain in myeloma with light chain deposition disease. (1733627)	Khamlichi A.A.... CognAc M.	1992
47	Structure of a monoclonal kappa chain of the V kappa IV subgroup in the kidney and plasma cells in light chain deposition disease. (1904072)	CognAc M.... Aucouturier P.	1991
48	An autopsy case of diffuse myelomatosis associated with systemic kappa light chain deposition disease (LCDD). A patho-anatomical, immunohistochemical and immunobiochemical study. (3135702)	Toyoda M.... Shinoda T.	1988
49	Association of systemic light-chain deposition disease and amyloidosis: a report of three patients with renal involvement. (3930115)	Jacquot C.... Bariety J.	1985
50	Light-chain deposition disease: its relation with AL-type amyloidosis. (6434789)	Ganeval D.... GrA1nfeld J.P.	1984

Genes related to Light Chain Deposition Disease

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Light Chain Deposition Disease:

- Elite gene

id	Symbol	Products	Description	Score	Implication
1	IGKV1-5		immunoglobulin kappa variable 1-5	25.55	GeneCards inferred via : Publications (show sections)
2	IGKC		immunoglobulin kappa constant	15.55	GeneCards inferred via : Publications (show sections)

Products for genes related to Light Chain Deposition Disease disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	2	-	2	2
2	Novus Biologicals	2	2	2	-

Variations for Light Chain Deposition Disease

Expression for genes affiliated with Light Chain Deposition Disease

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Light Chain Deposition Disease

Search GEO for disease gene expression data for Light Chain Deposition Disease.

Pathways for genes affiliated with Light Chain Deposition Disease

Sources:
⁴⁹PathCards, ⁵⁴Reactome, ³⁰KEGG, ⁵²QIAGEN
See all sources

Pathways related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Downstream Signaling Events Of B Cell Receptor (BCR)⁵⁴ Show member pathways Signaling by the B Cell Receptor (BCR)⁵⁴ Activation of RAS in B Cells⁵⁴	9.1	IGKC, IGKV1-5
2	PI-3K cascade⁵⁴ Show member pathways Downregulation of ERBB4 signaling⁵⁴ AKT phosphorylates targets in the nucleus⁵⁴ Signaling by SCF-KIT⁵⁴ PI3K events in ERBB2 signaling⁵⁴ Fc epsilon receptor (FCERI) signaling⁵⁴ PI3K events in ERBB4 signaling⁵⁴ Signaling by ERBB4⁵⁴ GAB1 signalosome⁵⁴ Negative regulation of the PI3K/AKT network⁵⁴ Role of LAT2/NTAL/LAB on calcium mobilization⁵⁴ PIP3 activates AKT signaling⁵⁴ Regulation of KIT signaling⁵⁴ AKT phosphorylates targets in the cytosol⁵⁴ AKT-mediated inactivation of FOXO1A⁵⁴ PI3K/AKT Signaling in Cancer⁵⁴ Constitutive PI3K/AKT Signaling in Cancer⁵⁴ PI3K/AKT activation⁵⁴	9.1	IGKC, IGKV1-5
3	Class I MHC mediated antigen processing and presentation⁵⁴ Show member pathways Ubiquitin mediated proteolysis³⁰ Antigen processing- Ubiquitination and Proteasome degradation⁵⁴ Adaptive Immune System⁵⁴	9.1	IGKC, IGKV1-5
4	Creation of C4 and C2 activators⁵⁴ Show member pathways FCERI mediated NF-kB activation⁵⁴ Classical antibody-mediated complement activation⁵⁴ Complement cascade⁵⁴ Initial triggering of complement⁵⁴ Role of phospholipids in phagocytosis⁵⁴ FCGR activation⁵⁴ Ficolins bind to repetitive carbohydrate structures on the target cell surface⁵⁴ Alternative complement activation⁵⁴ Lectin pathway of complement activation⁵⁴	9.1	IGKV1-5, IGKC
5	Fcgamma receptor (FCGR) dependent phagocytosis⁵⁴ Show member pathways Regulation of actin dynamics for phagocytic cup formation⁵⁴	9.1	IGKC, IGKV1-5
6	Antigen Activates B Cell Receptor Leading to Generation of Second Messengers⁵⁴ Show member pathways FCERI mediated Ca+2 mobilization⁵⁴ FCERI mediated MAPK activation⁵⁴ B-Cell Receptor Complex⁵²	9.1	IGKC, IGKV1-5
7	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell⁵⁴	9.1	IGKC, IGKV1-5
8	Binding and Uptake of Ligands by Scavenger Receptors⁵⁴ Show member pathways Scavenging by Class B Receptors⁵⁴ Scavenging of Heme from Plasma⁵⁴ Scavenging by Class H Receptors⁵⁴ Scavenging by Class A Receptors⁵⁴ Scavenging by Class F Receptors⁵⁴	9.1	IGKC, IGKV1-5

Compounds for genes affiliated with Light Chain Deposition Disease

GO Terms for genes affiliated with Light Chain Deposition Disease

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	9.1	IGKC, IGKV1-5
2	blood microparticle	GO:072562	8.8	IGKC, IGKV1-5

Biological processes related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	complement activation	GO:006956	9.3	IGKC, IGKV1-5
2	complement activation, classical pathway	GO:006958	9.2	IGKC, IGKV1-5
3	Fc-gamma receptor signaling pathway involved in phagocytosis	GO:038096	9.2	IGKC, IGKV1-5
4	regulation of immune response	GO:050776	9.1	IGKV1-5, IGKC
5	innate immune response	GO:045087	9.1	IGKC, IGKV1-5
6	Fc-epsilon receptor signaling pathway	GO:038095	9.0	IGKC, IGKV1-5
7	immune response	GO:006955	8.8	IGKC, IGKV1-5