Light Chain Deposition Disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Light Chain Deposition Disease

Sources:
⁴²NIH Rare Diseases, ⁶³Wikipedia, ³²MalaCards
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NIH Rare Diseases:⁴² Light chain deposition disease involves our immune system. it is caused by an excess buildup of immunoglobulin light chain in our tissues and organs. immunoglobulins, also known as antibodies, are special proteins made by immune cells. while an important part of our immune system, if these proteins become trapped in the tissues of the kidneys, lungs, skin, joints, or blood vessels, they can set off reactions that lead to tissue or organ inflammation (swelling) and damage. early signs and symptoms of light chain deposition disease may include protein in the urine, high blood pressure, decreased kidney function, and nephrotic syndrome. light chain deposition disease is often associated with multiple myeloma, monoclonal gammopathy of undetermined significance, or other disorders of abnormal overgrowth of lymph nodes. last updated: 4/2/2010

MalaCards: Light Chain Deposition Disease, also known as light-chain deposition disease, is related to amyloidosis and myeloma. An important gene associated with Light Chain Deposition Disease is CD14 (CD14 molecule), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Fc epsilon receptor (FCERI) signaling. The compounds latex and alpha-naphthyl acetate have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and lymph node.

Wikipedia:⁶³ Light chain deposition disease (LCDD) is a rare blood cell disease which is characterized by deposition... more...

Aliases & Classifications for Light Chain Deposition Disease

Sources:
⁴²NIH Rare Diseases, ⁴⁸Orphanet, ²⁶ICD10 via Orphanet, ⁵⁷SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases, Blood diseases

ICD10: ²⁶

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Certain disorders involving the immune mechanism

Other disorders involving the immune mechanism, not elsewhere classified

Other specified disorders involving the immune mechanism, not elsewhere classified

Aliases & Descriptions:

light chain deposition disease ⁴² ⁴⁸

light-chain deposition disease ⁴²

lcdd ⁴⁸

External Ids:

ICD10 via Orphanet²⁶ D89.8

SNOMED-CT via Orphanet⁵⁷ 373604002, 51319002

Related Diseases for Light Chain Deposition Disease

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
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Diseases related to Light Chain Deposition Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)

id	Related Disease	Score	Top Affiliating Genes
1	amyloidosis	31.2	IGKC
2	myeloma	31.1	IGKC, CD14
3	histiocytosis	30.2	CD68
4	rheumatoid arthritis	30.2	IGKC, CD68, CD14
5	kidney disease	10.7
6	multiple myeloma	10.7
7	liver disease	10.6
8	hepatitis a	10.4
9	heavy chain disease	10.4
10	hepatitis	10.4
11	retinal disease	10.4
12	retinitis	10.4
13	cerebritis	10.3
14	cerebral lymphoma	10.3
15	pigmentation disease	10.3
16	restrictive cardiomyopathy	10.3
17	retinal detachment	10.3
18	familial mediterranean fever	10.2
19	hepatitis c	10.2
20	macroglobulinemia	10.2
21	arteriosclerosis obliterans	10.2
22	portal hypertension	10.2
23	poems syndrome	10.2
24	arteriosclerosis	10.2
25	arthritis	10.2
26	arthropathy	10.2
27	brain disease	10.2
28	cholangitis	10.2
29	cholestasis	10.2
30	congestive heart failure	10.2
31	diabetes mellitus	10.2
32	hepatocellular carcinoma	10.2
33	hypertension	10.2
34	neuropathy	10.2
35	plasma cell neoplasm	10.2
36	retinal degeneration	10.2
37	stomach disease	10.2
38	sarcoidosis	10.0	CD14
39	peritonitis	10.0	CD14
40	b-cell lymphomas	10.0	CD14, IGKC
41	burkitt's lymphoma	10.0	IGKC, CD68, CD14

Graphical network of the top 20 diseases related to Light Chain Deposition Disease:

Clinical Features for Light Chain Deposition Disease

Drugs & Therapeutics for Light Chain Deposition Disease

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

Search CenterWatch for Light Chain Deposition Disease

Drug clinical trials:

Search ClinicalTrials for Light Chain Deposition Disease

Search NIH Clinical Center for Light Chain Deposition Disease

Search CenterWatch for Light Chain Deposition Disease

Genetic Tests for Light Chain Deposition Disease

Anatomical Context for Light Chain Deposition Disease

Sources:
³²MalaCards
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MalaCards organs/tissues related to Light Chain Deposition Disease:

³²

Kidney, Skin, Lymph node, Lung

Animal Models for Light Chain Deposition Disease or affiliated genes

Publications for Light Chain Deposition Disease

Genes related to Light Chain Deposition Disease

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
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Genes related to Light Chain Deposition Disease:

id	Symbol	Description	Score	Implication
1	CD14	CD14 molecule	22.76	GeneCards inferred : Publications, Disorders (show sections)
2	IGKV1-5	immunoglobulin kappa variable 1-5	17.76	GeneCards inferred : Publications, Disorders (show sections)
3	CD68	CD68 molecule	12.76	GeneCards inferred : Publications, Disorders (show sections)
4	IGKC	immunoglobulin kappa constant	7.76	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Light Chain Deposition Disease disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	4	4	4
2	LSBio	-	-	4

Genetic Variations for Light Chain Deposition Disease

Expression for genes affiliated with Light Chain Deposition Disease

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Light Chain Deposition Disease

Search GEO for disease gene expression data for Light Chain Deposition Disease.

Pathways for genes affiliated with Light Chain Deposition Disease

Sources:
⁵³Reactome
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Pathways related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Binding and Uptake of Ligands by Scavenger Receptors⁵³ Hide members Scavenging of Heme from Plasma⁵³	9.3	IGKC, IGKV1-5
2	Fc epsilon receptor (FCERI) signaling⁵³ Hide members Role of LAT2/NTAL/LAB on calcium mobilization⁵³	9.3	IGKC, IGKV1-5
3	Fcgamma receptor (FCGR) dependent phagocytosis⁵³ Hide members Regulation of actin dynamics for phagocytic cup formation⁵³	9.3	IGKC, IGKV1-5
4	Signaling by the B Cell Receptor (BCR)⁵³	9.3	IGKC, IGKV1-5
5	Classical antibody-mediated complement activation⁵³ Hide members FCERI mediated NF-kB activation⁵³ Creation of C4 and C2 activators⁵³ Complement cascade⁵³ Initial triggering of complement⁵³ Role of phospholipids in phagocytosis⁵³ Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell⁵³ FCGR activation⁵³	9.3	IGKV1-5, IGKC
6	FCERI mediated Ca+2 mobilization⁵³ Hide members FCERI mediated MAPK activation⁵³ Antigen Activates B Cell Receptor Leading to Generation of Second Messengers⁵³	9.3	IGKV1-5, IGKC
7	Immune System⁵³ Hide members Innate Immune System⁵³ Adaptive Immune System⁵³	8.8	CD14, IGKV1-5, IGKC

Compounds for genes affiliated with Light Chain Deposition Disease

Sources:
⁴⁴Novoseek
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Compounds related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	latex⁴⁴	9.1	CD14, CD68
2	alpha-naphthyl acetate⁴⁴	8.8	CD14, CD68

GO Terms for genes affiliated with Light Chain Deposition Disease

Sources:
¹⁶Gene Ontology
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Cellular components related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endosome membrane	GO:010008	9.0	CD14, CD68
2	extracellular region	GO:005576	8.8	CD14, IGKV1-5, IGKC
3	plasma membrane	GO:005886	7.7	CD14, CD68, IGKV1-5, IGKC

Biological processes related to Light Chain Deposition Disease according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	complement activation	GO:006956	9.4	IGKV1-5, IGKC
2	complement activation, classical pathway	GO:006958	9.4	IGKV1-5, IGKC
3	Fc-epsilon receptor signaling pathway	GO:038095	9.3	IGKC, IGKV1-5
4	Fc-gamma receptor signaling pathway involved in phagocytosis	GO:038096	9.2	IGKC, IGKV1-5
5	regulation of immune response	GO:050776	9.0	IGKV1-5, IGKC
6	innate immune response	GO:045087	8.8	IGKC, IGKV1-5, CD14