MCID: LMB014
MIFTS: 22

Limb-Body Wall Complex

Categories: Rare diseases, Fetal diseases

Aliases & Classifications for Limb-Body Wall Complex

MalaCards integrated aliases for Limb-Body Wall Complex:

Name: Limb-Body Wall Complex 49
Limb Body Wall Complex 49 55
Short Umbilical Cord Syndrome 49
Umbilical Cord, Short 49
Short Umbilical Cord 28
Aplasia of the Cord 49
Body Stalk Anomaly 49
Lbwc Syndrome 55
Cyllosomas 49

Characteristics:

Orphanet epidemiological data:

55
limb body wall complex
Inheritance: Not applicable; Prevalence: 1-9/100000 (Australia); Age of onset: Infancy,Neonatal; Age of death: early childhood;

Classifications:



External Ids:

Orphanet 55 ORPHA2369
ICD10 via Orphanet 33 Q87.8

Summaries for Limb-Body Wall Complex

NIH Rare Diseases : 49 Limb-body wall complex (LBWC) is a condition characterized by multiple, severe congenital abnormalities in a fetus. It typically results in openings in the anterior body wall (chest and belly) and defects of the limbs (arms and legs). Other features of LBWC may include facial clefts; a short or missing umbilical cord; scoliosis; neural tube defects; and abnormalities of the urogenital organs (i.e. kidney, bladder, and/or genitals). The exact cause of LBWC is unclear. Unfortunately, there is no cure for LBWC and it is considered to be incompatible with life (fatal). The majority of affected pregnancies end in fetal demise. Last updated: 6/21/2016

MalaCards based summary : Limb-Body Wall Complex, also known as limb body wall complex, is related to sirenomelia and microphthalmia, isolated 2. Affiliated tissues include kidney and placenta.

Wikipedia : 72 Limb body wall complex (LBWC) is a rare fetal malformation of unknown... more...

Related Diseases for Limb-Body Wall Complex

Diseases related to Limb-Body Wall Complex via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 sirenomelia 10.0
2 microphthalmia, isolated 2 10.0
3 cocaine abuse 9.9
4 amniotic band syndrome 9.9
5 pentalogy of cantrell 9.9
6 abdominal wall defect 9.9
7 blood group, i system 9.9
8 coloboma of macula 9.9
9 anus, imperforate 9.9
10 oeis complex 9.9
11 alpha-fetoprotein deficiency 9.9
12 omphalocele 9.9
13 choroiditis 9.9
14 placenta accreta 9.9

Graphical network of the top 20 diseases related to Limb-Body Wall Complex:



Diseases related to Limb-Body Wall Complex

Symptoms & Phenotypes for Limb-Body Wall Complex

Drugs & Therapeutics for Limb-Body Wall Complex

Search Clinical Trials , NIH Clinical Center for Limb-Body Wall Complex

Genetic Tests for Limb-Body Wall Complex

Genetic tests related to Limb-Body Wall Complex:

# Genetic test Affiliating Genes
1 Short Umbilical Cord 28

Anatomical Context for Limb-Body Wall Complex

MalaCards organs/tissues related to Limb-Body Wall Complex:

38
Kidney, Placenta

Publications for Limb-Body Wall Complex

Articles related to Limb-Body Wall Complex:

(show top 50) (show all 56)
# Title Authors Year
1
Thoracoschisis associated with Limb Body Wall Complex. ( 28540190 )
2017
2
Limb Body Wall Complex Associated with Placenta Accreta: A Mere Coincidence or a Sign of an Etiopathogenic Link? ( 28257587 )
2017
3
EP02.07: Limb body wall complex. ( 27645099 )
2016
4
Prenatal sonographic diagnosis of limb-body wall complex: case series of a rare congenital anomaly. ( 27257465 )
2016
5
Possible Genetic Origin of Limb-Body Wall Complex. ( 26111189 )
2015
6
Significance of fibrotic bands in utero - Amniotic band sequence with limb body wall complex: A rare case of fetal autopsy. ( 26549084 )
2015
7
Limb body wall complex, amniotic band sequence, or new syndrome caused by mutation in IQ Motif containing K (IQCK)? ( 26436108 )
2015
8
Early diagnosis of limb body wall complex: a case report. ( 24992795 )
2014
9
Omphalocele, exstrophy of cloaca, imperforate anus and spinal defect (OEIS Complex) with overlapping features of body stalk anomaly (limb body wall complex). ( 25400352 )
2014
10
Prenatal MRI evaluation of limb-body wall complex. ( 24928524 )
2014
11
Limb body wall complex with sacrococcygeal mass and agenesis of external genitalia. ( 23970900 )
2013
12
Limb body wall complex: a rare anomaly. ( 24014975 )
2013
13
Cases of limb-body wall complex: Early amnion rupture, vascular disruption, or abnormal splitting of the embryo? ( 27625829 )
2012
14
Prenatal ultrasound demonstration of limb-body wall complex with megacystis. ( 21791324 )
2011
15
First-trimester two-dimensional and three-dimensional ultrasound demonstration of craniofacial defects, abdominal wall defects and upper limb deficiency associated with limb-body wall complex. ( 22212340 )
2011
16
Amniotic band syndrome and/or limb body wall complex: split or lump. ( 23776348 )
2010
17
Limb-body wall complex in one fetus of a dizygotic twin pregnancy conceived by egg donation, in vitro fertilization and embryo transfer: prenatal diagnosis and literature review. ( 20045776 )
2009
18
Pentalogy of Cantrell vs. limb body wall complex: differential diagnosis of a severe malformation in early pregnancy. ( 19998210 )
2009
19
Limb-body wall complex with craniofacial defects after ovarian stimulation. ( 19126523 )
2008
20
Limb body wall complex. ( 18603699 )
2008
21
Limb body wall complex in a still born fetus: a case report. ( 18699998 )
2008
22
Second-trimester diagnosis of limb-body wall complex with literature review of pathogenesis. ( 17515306 )
2007
23
Limb body wall complex and amniotic band sequence in sibs. ( 17937432 )
2007
24
Prenatal ultrasonographical features of limb body wall complex: a review of etiopathogenesis and a new classification. ( 17886024 )
2007
25
On the spectrum of limb-body wall complex, exstrophy of the cloaca, and urorectal septum malformation sequence. ( 17431896 )
2007
26
Three-dimensional multiplanar ultrasound in a limb-body wall complex fetus: clinical evidence for counseling. ( 16581607 )
2006
27
Prenatal imaging of limb-body wall complex by magnetic resonance imaging. ( 15968622 )
2005
28
A case of limb-body wall complex diagnosed in utero. ( 12865119 )
2003
29
Limb body wall complex. ( 14530552 )
2003
30
Prenatal sonographic diagnosis of limb-body wall complex with craniofacial defects. ( 12858316 )
2003
31
Prenatal diagnosis of limb-body wall complex in early pregnancy using three-dimensional ultrasound. ( 12813769 )
2003
32
Prenatal diagnosis of acrania associated with facial defects, amniotic bands and limb-body wall complex. ( 12100428 )
2002
33
Limb-body wall complex: a case series. ( 12420845 )
2002
34
Prenatal diagnosis of limb-body wall complex with craniofacial defects, amniotic bands, adhesions and upper limb deficiency. ( 11360287 )
2001
35
Limb-body wall complex, report of 2 cases with their quintessence in prenatal diagnosis. ( 11460977 )
2001
36
Limb-body wall complex: a compound anomaly pattern in body-wall defects. ( 11527200 )
2001
37
Prenatal diagnosis of anophthalmos with limb-body wall complex. ( 11015711 )
2000
38
Prenatal diagnosis of limb-body wall complex using two- and three-dimensional ultrasound. ( 11113921 )
2000
39
Limb-body wall complex: 4 new cases illustrating the importance of examining placenta and umbilical cord. ( 11186176 )
2000
40
Prenatal diagnosis of limb-body wall complex. ( 9749415 )
1998
41
Limb body wall complex: analysis of eight fetuses. ( 9125325 )
1996
42
Limb body wall complex: craniofacial defects as a distinctive factor. ( 9125324 )
1996
43
Epidemiology of limb-body wall complex in Japan. ( 8092190 )
1994
44
Significance of fetography in prenatal diagnosis of limb-body wall complex (LBWC). ( 7907044 )
1993
45
Limb-body wall complex with anophthalmos and choroidal coloboma. ( 8372034 )
1993
46
Limb body wall complex: a critical review and a nosological proposal. ( 8279488 )
1993
47
Constrictive amniotic bands, amniotic adhesions, and limb-body wall complex: discrete disruption sequences with pathogenetic overlap. ( 1609831 )
1992
48
New case of limb body-wall complex associated with sirenomelia sequence. ( 1481813 )
1992
49
Limb-body wall complex associated with cocaine abuse: further evidence of cocaine's teratogenicity. ( 1386662 )
1992
50
Limb-body wall complex with complete absence of external genitalia after in vitro fertilization. ( 2001765 )
1991

Variations for Limb-Body Wall Complex

Expression for Limb-Body Wall Complex

Search GEO for disease gene expression data for Limb-Body Wall Complex.

Pathways for Limb-Body Wall Complex

GO Terms for Limb-Body Wall Complex

Sources for Limb-Body Wall Complex

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
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32 ICD10
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41 MeSH
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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