Aliases & Classifications for Limb Dystonia

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Aliases & Descriptions for Limb Dystonia:

Name: Limb Dystonia 45


Classifications:



Summaries for Limb Dystonia

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NIH Rare Diseases:45 Limb dystonia is characterized by excessive pulling of the muscles of a limb, such as the hand or foot. the arm or leg might also be involved. specific symptoms depend on the combinations of muscles involved and how hard each one is pulling. mild forms may be expressed as stiffness or soreness of a limb; more moderate forms are characterized by unwanted movements or postures; and in severe forms, abnormal postures may become fixed. common examples of limb dystonia include writer's cramp and musician's dystonia. in most cases, the cause of limb dystonia remains unknown. treatment is challenging. botulinum toxin injection, oral medications, and physical therapy may help some patients. last updated: 8/31/2014

MalaCards based summary: Limb Dystonia is related to dystonia and cervicitis. An important gene associated with Limb Dystonia is TIMM8A (Translocase Of Inner Mitochondrial Membrane 8 Homolog A (Yeast)). Affiliated tissues include temporal lobe.

Related Diseases for Limb Dystonia

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Graphical network of the top 20 diseases related to Limb Dystonia:



Diseases related to limb dystonia

Symptoms for Limb Dystonia

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Drugs & Therapeutics for Limb Dystonia

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Drugs for Limb Dystonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LevodopaapprovedPhase 433959-92-76047
Synonyms:
(-)-(3,4-Dihydroxyphenyl)alanine
(-)-3-(3,4-Dihydroxyphenyl)-L-alanine
(-)-3-(3,4-dihydroxyphenyl)-L-alanine
(-)-Dopa
(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
(−)-3-(3,4-dihydroxyphenyl)-L-alanine
(−)-dopa
.Beta.-(3, 4-Dihydroxyphenyl)alanine
.Beta.-(3,4-Dihydroxyphenyl)-L-alanine
1E83F927-C221-46AA-B90A-81B33C5F3868
2-Amino-3-(3,4-dihydroxyphenyl)propanoic acid
23734-74-9
25525-15-9
3, 4-Dihydroxy-L-phenylalanine
3, 4-Dihydroxyphenylalanine
3,4-DIHYDROXYPHENYLALANINE
3,4-Dihydroxy-L-phenylalanine
3,4-Dihydroxyphenyl-L-alanine
3,4-Dihydroxyphenylalanine
3,4-Dihydroxyphenylalanine (VAN)
3,4-dihydroxy-L-phenylalanine
3,4-dihydroxyphenylalanine
3-(3,4-Dihydroxypheny
3-(3,4-Dihydroxyphenyl)-L-alanine
3-Hydroxy-L-tyrosine
34241-25-3
37830_FLUKA
587-45-1
59-92-7
72572-99-7
72573-00-3
88250-23-1
90638-38-3
AC-11686
AC1L1LOR
AC1Q4U7F
BIDD:GT0158
BPBio1_000059
BSPBio_000053
BSPBio_002354
Bendopa
Bio-0575
Biodopa
Brocadopa
C00355
C9H11NO4
CAS-59-92-7
CCRIS 3766
CHEBI:15765
CHEMBL1009
CID6047
Cerepap
Cidandopa
D 9628
D00059
D0600
D9628
D9628_SIGMA
DAH
DB01235
DOPA
Deadopa
Dihydroxy-L-phenylalanine
Dihydroxyphenylalanine
DivK1c_000452
Dopa
Dopaflex
Dopaidan
Dopal
Dopal-Fher
Dopal-fher
Dopalina
Dopar
Dopar (TN)
Doparkine
Doparl
Dopasol
Dopaston
Dopaston SE
Dopastone
Dopastral
Dopicar
Doprin
EINECS 200-445-2
EU-0100454
Eldopal
Eldopar
Eldopatec
Eurodopa
HMS1568C15
HMS1922J14
HMS2090O08
HMS2093N04
HMS501G14
HSDB 3348
Helfo DOPA
 
Helfo-Dopa
Helfo-dopa
IDI1_000452
IV Levodopa
InChI=1/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14
Insulamina
KBio1_000452
KBio2_000934
KBio2_003502
KBio2_006070
KBioGR_001177
KBioSS_000934
L Dopa
L(-)-Dopa
L-(-)-Dopa
L-(3, 4-Dihydroxyphenyl)-.alpha.-alani
L-(3, 4-Dihydroxyphenyl)alanine
L-(o-Dihydroxyphenyl)alanine
L-.Beta.-(3,4-Dihydroxyphenyl)alanine
L-3,4-Dihydroxyphenylalanine
L-3,4-dihydroxyphenylalanine
L-3-(3,4-Dihydroxyphenyl)-Alanine
L-3-(3,4-Dihydroxyphenyl)alanine
L-3-Hydroxytyrosine
L-4-5-Dihydroxyphenylalanine
L-DOPA
L-DOPA, Parcopa, Atamet, Stalevo, Madopar, Prolopa, Dopar, 3,4-Dihydroxyphenylalanine, Levodopa
L-Dihydroxyphenylalanine
L-Dopa
L-O-Dihydroxyphenylalanine
L-b-(3,4-Dihydroxyphenyl)-a-alanine
L-beta-(3,4-Dihydroxyphenyl)-alpha-alanine
L-beta-(3,4-Dihydroxyphenyl)alanine
L-o-Hydroxytyrosine
LS-255
Laradopa
Larodopa
Ledopa
Levedopa
Levodopa
Levodopa (JP15/USP)
Levodopa (JP15/USP/INN)
Levodopa [USAN:INN:BAN:JAN]
Levodopum
Levodopum [INN-Latin]
Levopa
Lopac-D-9628
Lopac0_000454
MLS000028514
Maipedopa
MolPort-000-856-937
NCGC00015384-01
NCGC00016270-01
NCGC00016270-06
NCGC00093869-04
NINDS_000452
NSC 118381
NSC118381
PDSP1_001541
PDSP2_001525
Parda
Pardopa
Prestwick0_000017
Prestwick1_000017
Prestwick2_000017
Prestwick3_000017
Prestwick_185
Prodopa
Ro 4-6316
S1726_Selleck
SDCCGMLS-0066924.P001
SMR000058312
SPBio_000391
SPBio_001974
SPECTRUM2300205
Sobiodopa
Spectrum2_000496
Spectrum4_000539
Spectrum5_001899
Spectrum_000454
Syndopa
UNII-46627O600J
Veldopa
Weldopa
b-(3,4-Dihydroxyphenyl)-L-alanine
b-(3,4-Dihydroxyphenyl)-a-L-alanine
b-(3,4-Dihydroxyphenyl)alanine
beta-(3,4-Dihydroxyphenyl)-L-alanine
beta-(3,4-Dihydroxyphenyl)-alpha-L-alanine
beta-(3,4-Dihydroxyphenyl)-alpha-alanine
beta-(3,4-Dihydroxyphenyl)alanine
bmse000322
component of Sinemet
l)-L-alanine
nchembio.2007.55-comp26
nchembio.89-comp9
ne
β-(3,4-dihydroxyphenyl)alanine
2
DopamineapprovedPhase 4281462-31-7, 51-61-6681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine Hcl
Dopamine Hydrochloride
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
 
KBio1_000780
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
3Botulinum Toxins, Type APhase 4, Phase 3, Phase 1, Phase 2561
4Botulinum ToxinsPhase 4, Phase 3, Phase 2, Phase 1590
5DihydroxyphenylalaninePhase 4112
6
Pregabalinapproved, illicit, investigationalPhase 2327148553-50-85486971
Synonyms:
(3S)-3-(aminomethyl)-5-methylhexanoic acid
(R-)-3-isobutyl GABA
(S)-3-(Aminomethyl)-5-methylhexanoic acid
(S)-3-Isobutyl gaba
(S+)-3-isobutyl GABA
121GE001
148553-50-8
3-Isobutyl gaba
3-isobutyl GABA
AC-1158
AC1NUP03
AKOS005145504
C080245
C8H17NO2
CHEBI:236161
CHEMBL1059
CI 1008
CI-1008
CID5486971
 
D02716
DB00230
FT-0080911
HSDB 7530
LS-75191
Lyrica
Lyrica (TN)
MolPort-000-861-733
PD 144723
PD-144723
Pregabalin
Pregabalin (JAN/USAN/INN)
Pregabalin [USAN]
Pregablin
S-(+)-3-isobutylgaba
S1731_Selleck
SBB062901
TL8001062
TOS-BB-0910
UNII-55JG375S6M
7
TrihexyphenidylapprovedPhase 22144-11-65572
Synonyms:
(RS)-1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol
1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
144-11-6
5-20-02-00231 (Beilstein Handbook Reference)
52-49-3 (hydrochloride)
AB00053559
AC1L1KNB
Apo-Trihex
Apo-trihex
Apo-trihex (TN)
Artane Sequels
BPBio1_000971
BRD-A48180038-003-05-2
BRN 0088959
BSPBio_000881
BSPBio_002930
Benzhexol
Benzhexol Hydrochloride
Benzhexolum
C07171
C20H31NO
CHEMBL1490
CID5572
D08638
DB00376
DivK1c_000372
EINECS 205-614-4
HSDB 3196
IDI1_000372
KBio1_000372
KBio2_001112
KBio2_003680
KBio2_006248
KBio3_002150
KBioGR_000837
KBioSS_001112
L000821
LS-116010
Lopac0_001125
 
MolPort-001-783-510
NCGC00016003-06
NCGC00089797-02
NINDS_000372
NSC 12268
NSC12268
Oprea1_853391
PMS Trihexyphenidyl
Parkinane retard
Prestwick0_000701
Prestwick1_000701
Prestwick2_000701
Prestwick3_000701
SPBio_000757
SPBio_002802
Sedrena (free base)
Spectrum2_000829
Spectrum3_001375
Spectrum4_000369
Spectrum5_001465
Spectrum_000632
Trihexane
Trihexifenidilo
Trihexifenidilo [INN-Spanish]
Trihexy
Trihexylphenidyl
Trihexylphenidyle
Trihexylphenizyl
Trihexyphenidyl
Trihexyphenidyl (INN)
Trihexyphenidyl Hydrochloride
Trihexyphenidyl [INN:BAN]
Trihexyphenidyle
Trihexyphenidyle [INN-French]
Trihexyphenidylum
Trihexyphenidylum [INN-Latin]
Trihexyphénidyle
Triphenidyl
UNII-6RC5V8B7PO
trihexyphenidyl
8Calcium, DietaryPhase 23529
9RimabotulinumtoxinBPhase 1, Phase 213
10TNFR-Fc fusion proteinPhase 1, Phase 2367
11Gadobenic acidPhase 1, Phase 282
12Gadolinium DTPAPhase 1, Phase 282

Interventional clinical trials:

(show all 27)
idNameStatusNCT IDPhase
1Post Marketing Surveillance Study of DysportCompletedNCT00210431Phase 4
2Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled StudyRecruitingNCT01361373Phase 4
3The Use of Botox in Advanced Parkinson's Patients Experiencing PainActive, not recruitingNCT02472210Phase 4
4OnabotulinumtoxinA in the Management of Psychogenic DystoniaNot yet recruitingNCT02618889Phase 4
5Comparison of Electrophysiologic and Ultrasound Guidance for Onabotulinum Toxin A Injections in Focal Upper Extremity Dystonia and SpasticityRecruitingNCT02326818Phase 3
6Bilateral Internal Pallidum Stimulation in Primary Generalized DystoniaRecruitingNCT00272246Phase 2, Phase 3
7Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic ParaplegiaNot yet recruitingNCT02604186Phase 2, Phase 3
8Childhood Hypertonia of Central Origin: A Trial of Anticholinergic Treatment EffectsCompletedNCT00122044Phase 2
9“DOES MYOBLOC™ IMPROVE FUNCTIONAL HAND USE IN YOUNG CHILDREN WITH A HYPERTONIC UPPER EXTREMITY?”CompletedNCT00238641Phase 1, Phase 2
10Use of EMG to Assess Clinical HypertoniaCompletedNCT00472914Phase 1, Phase 2
11Endermotherapy for Children With Developmental DisabilitiesCompletedNCT01207570Phase 2
12Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKACompletedNCT00558753Phase 2
13An Electrophysiological Study Of E2014 In Healthy Adult Male Japanese And Caucasian SubjectsCompletedNCT00280384Phase 2
14ASIS for Enbrel in Plaque PsoriasisNot yet recruitingNCT02112097Phase 1, Phase 2
15Brain Function in Focal DystoniaCompletedNCT00102999
16Quantification of Upper Extremity HypertoniaCompletedNCT00285870
17DYSCAR: Characterization of DystoniaCompletedNCT00361465
18MyoSense- Automated Muscle Hypertonicity Classification SystemCompletedNCT02076581
19Transcranial Magnetic Stimulation (TMS) Studies of DystoniaCompletedNCT00017875
20Theta-burst Transcranial Magnetic StimulationCompletedNCT00878787
21Classification of Cerebral Palsy SubtypesCompletedNCT00072800
22Hypertonia in Patients With Cerebral PalsyCompletedNCT00123708
23Dystonia Coalition ProjectsRecruitingNCT01373424
24Extracorporeal Shock Wave Therapy (ESWT) for the Treatment of Spasticity in Persons With Spinal Cord InjuryRecruitingNCT02203994
25Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal DystoniaRecruitingNCT02334683
26Functional Connectivity in Primary Focal DystoniaRecruitingNCT01761903
27Exploring Hypertonia in Children With Cerebral PalsyRecruitingNCT01744158

Search NIH Clinical Center for Limb Dystonia

Genetic Tests for Limb Dystonia

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Anatomical Context for Limb Dystonia

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MalaCards organs/tissues related to Limb Dystonia:

33
Temporal lobe

Animal Models for Limb Dystonia or affiliated genes

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Publications for Limb Dystonia

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Articles related to Limb Dystonia:

(show all 27)
idTitleAuthorsYear
1
Isolated limb dystonia as presenting feature of Parkin disease. (24659796)
2014
2
Levodopa Responsiveness in Adult-onset Lower Limb Dystonia is Associated with the Development of Parkinson's Disease. (23610745)
2013
3
Psychogenic tetraparesis and bilateral upper limb dystonia, regressive under short propofol-induced sedation and during hepatic encephalopathy. (22902089)
2012
4
Drummer's lower limb dystonia. (22160433)
2012
5
The broadening application of chemodenervation in X-linked dystonia-parkinsonism (Part I): muscle afferent block versus botulinum toxin-A in cervical and limb dystonias. (21244305)
2011
6
Successful bilateral pallidal stimulation in a patient with isolated lower limb dystonia coexistent with Langerhans cell histiocytosis and coeliac disease. (22127949)
2011
7
Focal limb dystonia. (20590804)
2010
8
Clinical improvement of secondary focal limb dystonia in neurodegenerative disease following a five-day lidocaine infusion: a case report. (19013587)
2009
9
Blepharospasm and limb dystonia caused by Mohr-Tranebjaerg syndrome with a novel splice-site mutation in the deafness/dystonia peptide gene. (17534980)
2007
10
Restoring balance in focal limb dystonia with botulinum toxin. (18033603)
2007
11
Adult-onset primary lower limb dystonia. (16456826)
2006
12
Patterns of EMG-EMG coherence in limb dystonia. (15254933)
2004
13
Does sex influence age at onset in cranial-cervical and upper limb dystonia? (12531967)
2003
14
Ictal limb dystonia in temporal lobe epilepsy. an invasive video-EEG finding. (14641508)
2003
15
Progressive supranuclear palsy with asymmetric tau pathology presenting with unilateral limb dystonia. (12111365)
2002
16
Accuracy of muscle localization without EMG: implications for treatment of limb dystonia. (11889247)
2002
17
Focal limb dystonia in a patient with a cerebellar mass. (11448302)
2001
18
Posthemiplegic focal limb dystonia: a report of two cases. (9637205)
1998
19
Delayed onset limb dystonia following electric injury. (18591086)
1998
20
An aggressive approach to limb dystonia: a case report. (9596405)
1998
21
Abnormal motor unit synchronization of antagonist muscles underlies pathological co-contraction in upper limb dystonia. (9619186)
1998
22
Treatment of upper limb dystonia with botulinum toxin. (18638853)
1996
23
Upper-limb dystonia secondary to a midbrain hemorrhage. (8771076)
1996
24
Physiological effects produced by botulinum toxin treatment of upper limb dystonia. Changes in reciprocal inhibition between forearm muscles. (7600096)
1995
25
Bilateral limb dystonia due to chronic subdural hematoma. (2209675)
1990
26
Apparent G syndrome presenting as neck and upper limb dystonia and severe gastroesophageal reflux. (3425612)
1987
27
Limb dystonia in progressive supranuclear palsy. (3627456)
1987

Variations for Limb Dystonia

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Expression for genes affiliated with Limb Dystonia

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Search GEO for disease gene expression data for Limb Dystonia.

Pathways for genes affiliated with Limb Dystonia

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GO Terms for genes affiliated with Limb Dystonia

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Biological processes related to Limb Dystonia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chaperone-mediated protein transportGO:00723219.1TIMM8A, TOR1A

Sources for Limb Dystonia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet