MCID: LMB062
MIFTS: 47

Limb Ischemia

Categories: Cardiovascular diseases

Aliases & Classifications for Limb Ischemia

MalaCards integrated aliases for Limb Ischemia:

Name: Limb Ischemia 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050852

Summaries for Limb Ischemia

MalaCards based summary : Limb Ischemia is related to peripheral artery disease and critical limb ischemia. An important gene associated with Limb Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Aspirin and Pregabalin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and heart, and related phenotypes are cardiovascular system and cellular

Related Diseases for Limb Ischemia

Diseases related to Limb Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
id Related Disease Score Top Affiliating Genes
1 peripheral artery disease 27.8 ACE EDN1 IL6 NOS3 TNF TNNI3
2 critical limb ischemia 12.4
3 intermittent claudication 11.1
4 ischemia 11.0
5 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
6 iridogoniodysgenesis and skeletal anomalies 10.7 HIF1A VEGFA
7 angiosarcoma 10.7 HGF VEGFA
8 hypertonia 10.7 NOS3 VEGFA
9 aortic arch interruption 10.7 IL6 TNF
10 crohn disease-associated growth failure 10.7 IL6 VEGFA
11 early-onset zonular cataract 10.6 IL6 TNF VEGFA
12 progressive black carbon hyperpigmentation of infancy 10.6 EDN1 NOS3
13 pityriasis rosea 10.6 IL6 TNF VEGFA
14 spondylolysis 10.6 IL6 TNF VEGFA
15 scrotal carcinoma 10.6 FGF2 IL6 TNF
16 epidural neoplasm 10.6 VEGFA VWF
17 large intestine adenoma 10.6 FGF2 HIF1A VEGFA
18 pituitary infarct 10.5 IL6 TEK VEGFA
19 spirillary rat-bite fever 10.5 IL6 TNF
20 renal adenoma 10.5 TNF VEGFA VWF
21 tooth erosion 10.5 FGF2 VEGFA VWF
22 indolent myeloma 10.5 IL6 TNF VWF
23 tibialis tendinitis 10.5 FGF2 HGF TNF
24 anencephaly and spina bifida x-linked 10.5 ANGPT2 IL6 TNF
25 kidney pelvis papillary carcinoma 10.5 KDR VEGFA
26 gallbladder cancer 10.5 IL6 TNF VEGFA
27 lethal congenital contractural syndrome 2 10.5 EDN1 NOS3 VEGFA
28 pyruvate kinase deficiency, muscle type 10.5 ANGPT2 TEK VEGFA
29 toxoplasmosis 10.5 IL6 TNF
30 conduct disorder 10.5 ANGPT2 IL6 TNF
31 pasteurellosis 10.4 EDN1 IL6 TNF
32 optic nerve hypoplasia 10.4 FGF2 IL6 TNF
33 emphysema, congenital lobar 10.4 IL6 TNF VWF
34 intracranial primitive neuroectodermal tumor 10.4 EDN1 FGF2 IL6
35 childhood brainstem astrocytoma 10.4 EDN1 HGF
36 high pressure neurological syndrome 10.4 EDN1 IL6 TNF
37 trachea carcinoma in situ 10.4 IL6 KDR VEGFA
38 urinary bladder posterior wall cancer 10.4 FGF2 HIF1A IL6 VEGFA
39 posterior foramen magnum meningioma 10.4 FGF2 KDR VEGFA
40 cleft lip palate dysmorphism kumar type 10.4 HIF1A KDR VEGFA
41 vesiculobullous skin disease 10.4 KDR TEK VEGFA
42 thymus lymphoma 10.3 FGF2 HGF IL6 TNF
43 acute interstitial pneumonia 10.3 IL6 KDR TNF
44 ampulla of vater neoplasm 10.3 IL6 PGF TNF
45 intracranial hemorrhage in brain cerebrovascular malformations 10.3 FGF2 IL6 TNF VEGFA
46 artery disease 10.3
47 bipolar i disorder 10.3 ANGPT2 IL6 TNF VEGFA
48 c1 inhibitor deficiency 10.3 IL6 TNF TNNI3
49 breast disease 10.3 IL6 PGF TNF
50 fuhrmann syndrome 10.3 FGF2 KDR VEGFA

Graphical network of the top 20 diseases related to Limb Ischemia:



Diseases related to Limb Ischemia

Symptoms & Phenotypes for Limb Ischemia

MGI Mouse Phenotypes related to Limb Ischemia:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.46 ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
2 cellular MP:0005384 10.29 ANGPT2 CXCL12 FGF2 HGF HIF1A IL6
3 homeostasis/metabolism MP:0005376 10.29 ACE ANGPT2 EDN1 FGF2 HIF1A IL6
4 mortality/aging MP:0010768 10.28 ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
5 hematopoietic system MP:0005397 10.27 NOS3 TEK TNF VEGFA VWF ACE
6 growth/size/body region MP:0005378 10.25 PGF TEK TNF VEGFA ACE EDN1
7 immune system MP:0005387 10.2 ACE ANGPT2 CXCL12 HIF1A IL6 KDR
8 digestive/alimentary MP:0005381 10.14 HIF1A IL6 NOS3 TNF VEGFA VWF
9 embryo MP:0005380 10.13 EDN1 HGF HIF1A KDR PGF TEK
10 muscle MP:0005369 10.11 VEGFA CXCL12 EDN1 FGF2 HIF1A IL6
11 liver/biliary system MP:0005370 10.09 IL6 KDR NOS3 TNF VEGFA HGF
12 nervous system MP:0003631 10 TNF VEGFA VWF CXCL12 EDN1 FGF2
13 neoplasm MP:0002006 9.87 ACE FGF2 HIF1A IL6 PGF TNF
14 respiratory system MP:0005388 9.81 ANGPT2 HIF1A IL6 KDR NOS3 PGF
15 skeleton MP:0005390 9.56 EDN1 FGF2 HIF1A IL6 KDR NOS3
16 vision/eye MP:0005391 9.32 ANGPT2 FGF2 HIF1A IL6 KDR NOS3

Drugs & Therapeutics for Limb Ischemia

Drugs for Limb Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 235)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 50-78-2 2244
2
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
3
Menthol Approved Phase 4,Phase 2,Phase 3,Phase 1 2216-51-5 16666
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
5
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
6
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
7
Metronidazole Approved Phase 4 443-48-1 4173
8
Povidone Approved Phase 4 9003-39-8
9 Povidone-iodine Approved Phase 4 25655-41-8
10
Teicoplanin Approved Phase 4 61036-62-2
11
Ephedrine Approved Phase 4 299-42-3 9294
12
Norepinephrine Approved Phase 4 51-41-2 439260
13
Oxymetazoline Approved Phase 4 1491-59-4 4636
14
Phenylephrine Approved Phase 4 59-42-7 6041
15
Pseudoephedrine Approved Phase 4 90-82-4 7028
16
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3 33069-62-4 36314
17
Alprostadil Approved, Investigational Phase 4,Phase 2 745-65-3 149351
18
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
19
Lenograstim Approved Phase 4,Phase 1,Phase 2,Early Phase 1 135968-09-1
20
Ramipril Approved Phase 4 87333-19-5 5362129
21
Cilostazol Approved Phase 4,Phase 2 73963-72-1 2754
22
Zinc Approved Phase 4 7440-66-6 32051 23994
23
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
24
Vorapaxar Approved Phase 4 618385-01-6
25
Insulin Glargine Approved Phase 4 160337-95-1
26
Glucosamine Approved, Nutraceutical Phase 4 3416-24-8 439213
27
Clopidogrel Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 120202-66-6, 113665-84-2 60606
28
Iodine Investigational Phase 4 7553-56-2 807
29 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
30 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Early Phase 1
31 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Early Phase 1
32 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Early Phase 1
33 Antipyretics Phase 4,Phase 3,Phase 2,Early Phase 1
34 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
35 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
36 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
37 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
38 Platelet Aggregation Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
39 Anti-Anxiety Agents Phase 4
40 Anticonvulsants Phase 4
41 calcium channel blockers Phase 4
42 Calcium, Dietary Phase 4,Phase 2
43 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
44 Psychotropic Drugs Phase 4
45 Tranquilizing Agents Phase 4
46 Amoxicillin-Potassium Clavulanate Combination Phase 4
47 Anti-Bacterial Agents Phase 4,Phase 2
48 Antibiotics, Antitubercular Phase 4,Phase 2
49 Anti-Infective Agents Phase 4,Phase 2
50 Anti-Infective Agents, Local Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 485)

id Name Status NCT ID Phase Drugs
1 Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia Unknown status NCT01104441 Phase 4
2 Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia Unknown status NCT00403780 Phase 4 pregabalin;placebo
3 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part II) (DCLI-II) Unknown status NCT01173094 Phase 4
4 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part I) Unknown status NCT01171703 Phase 4
5 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
6 The Amputation Surgical Site Infection Trial (ASSIT) Unknown status NCT02018094 Phase 4 Co-amoxiclav;Iodine;Metronidazole;Chlorhexidine;Teicoplanin;Clindamycin
7 Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery Unknown status NCT01147419 Phase 4
8 A Pilot Trial of Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients Unknown status NCT02203630 Phase 4 Phenylephrine;Norepinephrine
9 Comprehensive Reparative Therapy in Ischemic Stroke COMplex Repair in Ischemic Stroke-Arm Unknown status NCT02581371 Phase 4 Cerebrolysin infusion
10 ATHERO: Advanced Technology Halting Early Re-Stenosis and Occlusion Unknown status NCT00407940 Phase 4
11 Self Expanding Nitinol Stent Versus Percutaneous Transluminal Arterial Angioplasty (PTA) With Optional Bailout Stenting in Case of PTA Failure in Patients With Symptomatic Critical Limb Ischemia or Severe Intermittent Claudication (EXPAND) Completed NCT00906022 Phase 4
12 Non-Interventional Post Marketing Surveillance Study of Neovasculgen® in Patients With Chronic Lower Limb Ischemia Completed NCT02369809 Phase 4 Neovasculgen®
13 Drug Eluting Balloon in peripherAl inTErvention For Below The Knee Angioplasty Evaluation Completed NCT01558505 Phase 4
14 Cryoplasty CLIMB-registry Completed NCT00459888 Phase 4
15 Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE) Completed NCT00883246 Phase 4
16 Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV Completed NCT00596752 Phase 4 Alprostadil
17 DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions Completed NCT00637741 Phase 4
18 Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp) Completed NCT00300690 Phase 4
19 Efficacy Study of Iliac Stents to Treat TASC A-B-C-D Iliac Artery Lesions Completed NCT00764777 Phase 4
20 Protective Effects of L-arginine During Reperfusion by Femoropopliteal Bypass for Lower Limb Ischemic Syndrome in Humans Completed NCT02117206 Phase 4 L-arginine (L-arginine Veyron);Nacl
21 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
22 Prevention of Ischemic Events in Patients With Peripheral Arterial Disease Completed NCT00761969 Phase 4
23 Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery Completed NCT01427621 Phase 4
24 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
25 Clinical and Cost Effectiveness of ACE Inhibitor, Ramipril, in Intermittent Claudicants Completed NCT01037530 Phase 4 Ramipril
26 The Study to Compare SMART Nitinol Stent and Balloon Angioplasty Completed NCT00309595 Phase 4
27 The Study to Compare the Cordis SMART™ Stent System With the Bard® Luminexx™ Stent Completed NCT00235131 Phase 4
28 Efficacy and Safety of Qizhitongluo Capsule in the Recovery Phase of Ischemic Stroke Completed NCT01762163 Phase 4 Qizhitongluo Capsule;Naoxintong Capsule;Aspirin Enteric-coated Tablets;placebo
29 Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia Recruiting NCT02563535 Phase 4
30 Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging Recruiting NCT02807779 Phase 4 Dexamethasone infusion
31 Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery Recruiting NCT02085551 Phase 4
32 Clinical Study of the Aorta-femoral Bypass and Hybrid Intervention and the Iliac Arteries With Stenting and Plasty of the Common Femoral Artery Effectiveness in Patients With the Iliac Segment and Femoral Artery Occlusive Disease (TASC C, D) Active, not recruiting NCT02580084 Phase 4
33 Effectiveness of Adventitial Dexamethasone in Peripheral Artery Disease Active, not recruiting NCT01983449 Phase 4 Dexamethasone Sodium Phosphate Injection, USP
34 Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study) Not yet recruiting NCT02829151 Phase 4 Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) );Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel;Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol
35 Vorapaxar and Lower Extremity Bypass Grafts Not yet recruiting NCT02975583 Phase 4 Vorapaxar;Placebos
36 Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia Terminated NCT00504088 Phase 4
37 Normalization of Fasting Glucose and the Incidence of Restenosis After Peripheral Angioplasty Terminated NCT01150617 Phase 4 Insulin glargine plus insulin analogues
38 Use Art-assist and Neupogen to Treat Chronic Limb Ischemia Withdrawn NCT02408991 Phase 4 Neupogen
39 Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia Unknown status NCT00539266 Phase 2, Phase 3
40 VADOplex Critical Limb Ischemia Study Unknown status NCT02034539 Phase 2, Phase 3
41 Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia Unknown status NCT00434616 Phase 2, Phase 3
42 Distal Venous Arterialisation of Ischemic Limb Unknown status NCT01211925 Phase 2, Phase 3 Aspirin
43 Transfer of Cardioprotection During RIPC Unknown status NCT01956708 Phase 2, Phase 3
44 Pain and Music Therapy in Patients Suffering Arteritis Unknown status NCT01323504 Phase 3
45 NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
46 The Effect of Remote Ischemic Preconditioning (RIPC) on Blood Pressure and Its Vascular Protection Effect Unknown status NCT02414997 Phase 3
47 Bone Marrow Aspirate Concentrate (BMAC) for Treatment of Critical Limb Ischemia (CLI) Completed NCT01245335 Phase 3
48 An Efficacy and Safety Study of Ixmyelocel-T in Patients With Critical Limb Ischemia (CLI) Completed NCT01483898 Phase 3
49 Bone Marrow Autograft in Limb Ischemia Completed NCT00904501 Phase 3
50 Efficacy and Safety of XRP0038/NV1FGF in Critical Limb Ischemia Patients With Skin Lesions Completed NCT00566657 Phase 3

Search NIH Clinical Center for Limb Ischemia

Genetic Tests for Limb Ischemia

Anatomical Context for Limb Ischemia

MalaCards organs/tissues related to Limb Ischemia:

39
Bone, Bone Marrow, Heart, Endothelial, Kidney, Brain, Liver

Publications for Limb Ischemia

Articles related to Limb Ischemia:

(show top 50) (show all 784)
id Title Authors Year
1
Biodegradable Carriers for Delivery of VEGF Plasmid DNA for the Treatment of Critical Limb Ischemia. ( 28848442 )
2017
2
Limb Ischemia after Heart Transplantation: An Unusual Case of Tissue Embolism. ( 28828026 )
2017
3
Cell therapy in critical limb ischemia: A comprehensive analysis of two cell therapy products. ( 27914820 )
2017
4
Surgical Interventions for Organ and Limb Ischemia Associated With Primary and Secondary Antiphospholipid Antibody Syndrome With Arterial Involvement. ( 28920529 )
2017
5
The Effect of Charcot Neuroarthropathy on Limb Preservation in Diabetic Patients with Foot Wound and Critical Limb Ischemia after Balloon Angioplasty. ( 28951878 )
2017
6
Catheter directed thrombolysis is not limited to acute limb ischemia treatment- the experience from vascular surgery division. ( 28849898 )
2017
7
Mitochondrial-Targeted Antioxidant Maintains Blood Flow, Mitochondrial Function, and Redox Balance in Old Mice Following Prolonged Limb Ischemia. ( 28869535 )
2017
8
Association of arterial calcification with chronic limb ischemia in patients with peripheral artery disease. ( 28870682 )
2017
9
Prevalence and Impact of Critical Limb Ischemia on In-Hospital Outcome in Transcatheter Aortic Valve Implantation in Germany. ( 28870876 )
2017
10
A nationwide analysis of 30-day readmissions related to critical limb ischemia. ( 28836900 )
2017
11
Association Between Preoperative Frailty and Mortality in Patients With Critical Limb Ischemia Following Infrainguinal Bypass Surgerya88- Usefulness of the Barthel Index. ( 28835590 )
2017
12
Pattern and distribution of peripheral arterial disease in diabetic patients with critical limb ischemia (rutherford clinical category 4-6). ( 28876565 )
2017
13
Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia. ( 27853042 )
2017
14
Characteristics and clinical outcomes of repeat endovascular therapy after infrapopliteal balloon angioplasty in patients with critical limb ischemia. ( 28799724 )
2017
15
Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia. ( 28397742 )
2017
16
Inframalleolar Interventions in Critical Limb Ischemia: Trailblazing the Path Toward the Final Frontier? ( 28057290 )
2017
17
Risk of major amputation or death among patients with critical limb ischemia initially treated with endovascular intervention, surgical bypass, minor amputation, or conservative management. ( 28760065 )
2017
18
Letter by Czihal and Hoffmann Regarding Article, "Prevalence of Tibial Artery and Pedal Arch Patency by Angiography in Patients With Critical Limb Ischemia and Noncompressible Ankle Brachial Index". ( 28916606 )
2017
19
Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes. ( 28900239 )
2017
20
A pro-angiogenic degradable Mg-poly(lactic-co-glycolic acid) implant combined with rhbFGF in a rat limb ischemia model. ( 28951330 )
2017
21
Reduced amputation rate with isovolemic hemodilution in critical limb ischemia patients. ( 28922142 )
2017
22
Occlusive Shrinkage of Ovation Endograft Presenting as Acute Lower Limb Ischemia: Effective Endovascular Management. ( 28868311 )
2017
23
Association between statin therapy and amputation-free survival in patients with critical limb ischemia in the CRITISCH registry. ( 28807382 )
2017
24
Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects. ( 28789654 )
2017
25
Fractional flow reserve in below the knee arteries with critical limb ischemia and validation against gold-standard morphologic, functional measures and long term clinical outcomes. ( 28866449 )
2017
26
Long-Term Outcomes of Successful Endovascular Therapy Via the Retrograde Approach for Below-the-Knee Chronic Total Occlusion in Patients With Critical Limb Ischemia After a Failed Antegrade Approach. ( 28045669 )
2017
27
Decision-Making in Critical Limb Ischemia: A Markov Simulation. ( 28739455 )
2017
28
Moderate Exercise Allows for shorter Recovery Time in Critical Limb Ischemia. ( 28790926 )
2017
29
Analysis of IN.PACT DEEP trial on the association between changes in perfusion from pre- to postrevascularization and clinical outcomes in critical limb ischemia. ( 28862375 )
2017
30
Neutrophil-to-lymphocyte ratio is effective prognostic indicator for post-amputation patients with critical limb ischemia. ( 28042626 )
2017
31
Staged endovascular repair of critical limb ischemia in high risk patients: the procedural and clinical outcomes. ( 28884985 )
2017
32
Coronary Artery Disease in Patients with Critical Limb Ischemia Undergoing Major Amputation or Not. ( 28740785 )
2017
33
Predictive Parameters for Clinical Outcome in Patients with Critical Limb Ischemia Who Underwent Percutaneous Transluminal Angioplasty (PTA): A Systematic Review. ( 28924874 )
2017
34
Outcomes of Open and Endovascular Lower Extremity Revascularization in Current Smokers With Intermittent Claudication and Critical Limb Ischemia. ( 27763293 )
2016
35
Autologous bone marrow mononuclear cell therapy for critical limb ischemia is effective and durable. ( 27021379 )
2016
36
New treatment possibilities for patients with advanced coronary artery disease and critical limb ischemia - a feasibility study. ( 27980553 )
2016
37
The expression profile of angiogenic genes in critical limb ischemia popliteal arteries. ( 27511996 )
2016
38
The Current State of Critical Limb Ischemia: A Systematic Review. ( 27551978 )
2016
39
Contemporary Management of CriticalA Limb Ischemia: The BEST Is Yet to Come. ( 27012784 )
2016
40
Influence of UGT2B7, CYP3A4, and OPRM1 Gene Polymorphisms on Transdermal Buprenorphine Pain Control in Patients with Critical Lower Limb Ischemia Awaiting Revascularization. ( 26407542 )
2016
41
Endovascular Treatment of Acute Aortic Occlusion with Critical Limb Ischemia using an Angiojet device. ( 27522976 )
2016
42
Granulocyte colony-stimulating factor improves the efficacy of autologous bone marrow-derived mononuclear cell transplantation treatment for lower limb ischemia. ( 27958690 )
2016
43
2014 JAPAN Critical Limb Ischemia Database (JCLIMB) Annual Report. ( 28018516 )
2016
44
Augmentation of arterial blood velocity with electrostimulation in patients with critical limb ischemia unsuitable for revascularization. ( 27154976 )
2016
45
Successful Endovascular Repair of an Iatrogenic Perforation of the Superficial Femoral Artery Using Self-Expanding Nitinol Supera Stents in a Patient with Acute Thromboembolic Limb Ischemia. ( 27213074 )
2016
46
Loss of kidney function in patients with critical limb ischemia treated endovascularly or surgically. ( 27139786 )
2016
47
Simvastatin augments revascularization and reperfusion in a murine model of hind limb ischemia - Multimodal imaging assessment. ( 27984781 )
2016
48
Drug-Eluting Balloon Angioplasty for Below the Knee Lesions in End Stage Renal Disease Patients with Critical Limb Ischemia: Midterm Results. ( 27910185 )
2016
49
Retrograde Approach Using Surgical Cutdown Technique for Limb Salvage in a Case of Critical Limb Ischemia With Severely Calcified Tibial Occlusive Disease. ( 27207678 )
2016
50
Outcomes in Critical Limb Ischemia Compared by Distance from Referral Center. ( 27531079 )
2016

Variations for Limb Ischemia

Expression for Limb Ischemia

Search GEO for disease gene expression data for Limb Ischemia.

Pathways for Limb Ischemia

Pathways related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.15 CXCL12 EDN1 FGF2 HGF HIF1A IL6
2
Show member pathways
13.85 ANGPT2 CXCL12 FGF2 HGF HIF1A IL6
3
Show member pathways
13.71 CXCL12 FGF2 HGF IL6 KDR NOS3
4
Show member pathways
13.66 ANGPT2 CXCL12 EDN1 HGF IL6 KDR
5
Show member pathways
13.55 CXCL12 FGF2 HGF IL6 KDR NOS3
6
Show member pathways
13.54 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
7
Show member pathways
13.47 FGF2 HGF KDR TEK TNF VEGFA
8
Show member pathways
13.36 FGF2 HGF HIF1A IL6 TEK TNF
9
Show member pathways
13.32 CXCL12 FGF2 HGF IL6 KDR PGF
10
Show member pathways
13.32 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
11
Show member pathways
13.3 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
12
Show member pathways
13.15 CXCL12 FGF2 HGF IL6 KDR NOS3
13
Show member pathways
13.07 CXCL12 FGF2 HGF IL6 KDR PGF
14
Show member pathways
13.06 ACE CXCL12 FGF2 HGF HIF1A IL6
15
Show member pathways
12.87 HGF KDR PGF VEGFA VWF
16
Show member pathways
12.74 ANGPT2 FGF2 HGF KDR PGF TEK
17
Show member pathways
12.7 CXCL12 FGF2 HGF IL6 KDR PGF
18 12.65 CXCL12 FGF2 HGF HIF1A IL6 PGF
19
Show member pathways
12.63 ANGPT2 FGF2 IL6 NOS3 TEK TNF
20 12.43 ANGPT2 FGF2 HGF IL6 KDR NOS3
21
Show member pathways
12.37 KDR NOS3 PGF VEGFA
22
Show member pathways
12.24 FGF2 KDR NOS3 VEGFA
23 12.24 FGF2 HGF HIF1A KDR TNF VEGFA
24 12.18 HIF1A IL6 TNF VEGFA
25 12.13 EDN1 KDR NOS3 TNF VEGFA
26 12.12 ANGPT2 FGF2 KDR TEK
27 11.97 FGF2 HGF IL6 KDR TNNI3 VEGFA
28 11.94 EDN1 IL6 NOS3 TNF VEGFA
29
Show member pathways
11.93 IL6 NOS3 TNF
30 11.92 EDN1 IL6 TNF
31
Show member pathways
11.89 HIF1A KDR NOS3 PGF VEGFA
32 11.87 FGF2 IL6 TNNI3
33 11.86 FGF2 HGF HIF1A IL6 TNF VEGFA
34 11.85 CXCL12 IL6 TEK TNF VEGFA
35 11.8 ANGPT2 EDN1 HIF1A IL6 NOS3 TEK
36 11.75 CXCL12 FGF2 HGF IL6 PGF
37 11.74 CXCL12 EDN1 HIF1A VEGFA
38
Show member pathways
11.68 IL6 TNF VEGFA
39 11.64 EDN1 HIF1A NOS3 VEGFA
40 11.63 EDN1 FGF2 HGF IL6 TNF
41 11.59 FGF2 KDR TNNI3
42 11.58 FGF2 HGF IL6 VEGFA
43 11.57 HIF1A IL6 VEGFA
44 11.55 FGF2 KDR VEGFA
45 11.54 HGF IL6 TNF
46 11.51 FGF2 KDR VEGFA
47
Show member pathways
11.47 HGF KDR VEGFA
48 11.44 ANGPT2 EDN1 HIF1A VEGFA
49
Show member pathways
11.31 EDN1 HIF1A VEGFA
50 11.26 ANGPT2 CXCL12 HGF IL6 TNF

GO Terms for Limb Ischemia

Cellular components related to Limb Ischemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
2 external side of plasma membrane GO:0009897 9.62 ACE CXCL12 IL6 TNF
3 extracellular region GO:0005576 9.44 ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
4 platelet alpha granule lumen GO:0031093 9.43 HGF VEGFA VWF
5 Weibel-Palade body GO:0033093 9.16 EDN1 VWF

Biological processes related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.97 FGF2 KDR TNF VWF
2 peptidyl-tyrosine phosphorylation GO:0018108 9.93 FGF2 HGF KDR TEK
3 positive regulation of protein phosphorylation GO:0001934 9.92 KDR TEK TNF VEGFA
4 positive regulation of cell migration GO:0030335 9.92 CXCL12 EDN1 HGF KDR VEGFA
5 positive regulation of cell proliferation GO:0008284 9.92 CXCL12 EDN1 FGF2 HGF IL6 KDR
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 FGF2 IL6 KDR TEK TNF
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.9 EDN1 IL6 TNF
8 activation of MAPK activity GO:0000187 9.9 FGF2 HGF TNF
9 cellular response to hypoxia GO:0071456 9.9 EDN1 HIF1A VEGFA
10 positive regulation of protein kinase B signaling GO:0051897 9.89 IL6 TEK TNF
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.88 HGF IL6 VEGFA
12 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.88 IL6 TNF VEGFA
13 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.87 HGF IL6 VEGFA
14 cellular response to interleukin-1 GO:0071347 9.87 EDN1 HIF1A IL6
15 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.86 KDR PGF VEGFA
16 regulation of blood pressure GO:0008217 9.86 ACE EDN1 NOS3
17 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.86 HGF KDR TEK
18 response to mechanical stimulus GO:0009612 9.85 ANGPT2 CXCL12 IL6
19 positive regulation of smooth muscle cell proliferation GO:0048661 9.84 EDN1 IL6 TNF
20 vasculogenesis GO:0001570 9.84 KDR TNNI3 VEGFA
21 response to heat GO:0009408 9.83 CXCL12 IL6 NOS3
22 positive regulation of cell adhesion GO:0045785 9.81 CXCL12 TNF VEGFA
23 positive regulation of cell division GO:0051781 9.8 FGF2 PGF VEGFA
24 response to hypoxia GO:0001666 9.8 ANGPT2 CXCL12 EDN1 HIF1A PGF TEK
25 positive regulation of nitric oxide biosynthetic process GO:0045429 9.79 EDN1 IL6 TNF
26 positive regulation of MAP kinase activity GO:0043406 9.76 EDN1 FGF2 TNF VEGFA
27 angiogenesis GO:0001525 9.76 ANGPT2 FGF2 HIF1A KDR NOS3 PGF
28 blood vessel morphogenesis GO:0048514 9.75 ANGPT2 EDN1 HIF1A
29 positive regulation of endothelial cell migration GO:0010595 9.73 EDN1 KDR TEK VEGFA
30 embryonic hemopoiesis GO:0035162 9.72 HIF1A KDR
31 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.72 HIF1A VEGFA
32 heart contraction GO:0060047 9.72 ACE TNNI3
33 cellular response to hepatocyte growth factor stimulus GO:0035729 9.72 HGF IL6
34 positive regulation of focal adhesion assembly GO:0051894 9.72 KDR TEK VEGFA
35 positive regulation of positive chemotaxis GO:0050927 9.71 KDR VEGFA
36 negative regulation of hormone secretion GO:0046888 9.71 EDN1 IL6
37 positive regulation of chemokine production GO:0032722 9.71 HIF1A IL6 TNF
38 animal organ regeneration GO:0031100 9.71 ANGPT2 CXCL12 HGF PGF
39 neutrophil mediated immunity GO:0002446 9.7 ACE IL6
40 negative regulation of lipid storage GO:0010888 9.69 IL6 TNF
41 positive regulation of receptor biosynthetic process GO:0010870 9.68 EDN1 HIF1A
42 positive regulation of axon extension involved in axon guidance GO:0048842 9.67 CXCL12 VEGFA
43 cell migration involved in sprouting angiogenesis GO:0002042 9.67 FGF2 KDR VEGFA
44 positive chemotaxis GO:0050918 9.67 CXCL12 FGF2 HGF VEGFA
45 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.66 IL6 TNF
46 positive regulation of mast cell chemotaxis GO:0060754 9.65 PGF VEGFA
47 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.65 EDN1 NOS3
48 induction of positive chemotaxis GO:0050930 9.65 CXCL12 PGF VEGFA
49 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.64 ACE VEGFA
50 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.64 KDR VEGFA

Molecular functions related to Limb Ischemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.62 FGF2 HGF KDR TEK
2 chemoattractant activity GO:0042056 9.46 CXCL12 FGF2 HGF VEGFA
3 cytokine activity GO:0005125 9.43 CXCL12 EDN1 FGF2 IL6 TNF VEGFA
4 vascular endothelial growth factor receptor binding GO:0005172 9.26 PGF VEGFA
5 growth factor activity GO:0008083 9.1 CXCL12 FGF2 HGF IL6 PGF VEGFA

Sources for Limb Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
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65 SNOMED-CT via HPO
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