MCID: LMB062
MIFTS: 52

Limb Ischemia

Categories: Cardiovascular diseases

Aliases & Classifications for Limb Ischemia

MalaCards integrated aliases for Limb Ischemia:

Name: Limb Ischemia 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050852
UMLS 69 C2945695

Summaries for Limb Ischemia

MalaCards based summary : Limb Ischemia is related to critical limb ischemia and peripheral artery disease. An important gene associated with Limb Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Aspirin and Pregabalin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related phenotypes are cardiovascular system and cellular

Related Diseases for Limb Ischemia

Diseases related to Limb Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 critical limb ischemia 33.4 ANGPT2 HGF IL6 TEK TNF VEGFA
2 peripheral artery disease 30.4 ACE IL6 NOS3 VEGFA
3 ischemia 30.2 ACE CXCL12 EDN1 HIF1A NOS3 VEGFA
4 intermittent claudication 30.1 ACE IL6 VEGFA VWF
5 peripheral vascular disease 29.9 ACE IL6 VEGFA VWF
6 infective endocarditis 29.7 IL6 TNF TNNI3
7 endocarditis 29.6 IL6 TNF TNNI3
8 vascular disease 29.2 ACE EDN1 FGF2 NOS3 VEGFA VWF
9 coronary artery anomaly 29.0 ACE EDN1 IL6 NOS3 TNNI3
10 arteries, anomalies of 28.2 ACE EDN1 IL6 NOS3 PGF TNF
11 scorpion envenomation 10.5 IL6 TNF
12 intravascular papillary endothelial hyperplasia 10.5 HIF1A VEGFA
13 hemifacial spasm 10.5 NOS3 VEGFA
14 wrinkles 10.5 HGF VEGFA
15 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
16 nodular goiter 10.4 HGF IL6 VEGFA
17 eales disease 10.4 IL6 TNF VEGFA
18 arteriosclerosis obliterans 10.4 HGF HIF1A IL6
19 prinzmetal's variant angina 10.4 EDN1 NOS3
20 rosacea 10.4 IL6 TNF VEGFA
21 infiltrating angiolipoma 10.4 VEGFA VWF
22 cerebral artery occlusion 10.4 HIF1A NOS3 TNF
23 laryngitis 10.4 FGF2 IL6 TNF
24 female reproductive system disease 10.4 IL6 TNF VEGFA
25 endotheliitis 10.3
26 streptococcal toxic-shock syndrome 10.3 IL6 TNF
27 osteosclerotic myeloma 10.3 IL6 TNF VWF
28 angiodysplasia 10.3 FGF2 VEGFA VWF
29 lymphangiosarcoma 10.3 TNF VEGFA VWF
30 angiokeratoma circumscriptum 10.3 KDR VEGFA
31 gastrointestinal system cancer 10.3 IL6 TNF VEGFA
32 chronic mountain sickness 10.3 EDN1 NOS3 VEGFA
33 pyogenic granuloma 10.3 ANGPT2 TEK VEGFA
34 null-cell leukemia 10.3 IL6 TNF
35 varicose veins 10.3 HIF1A VEGFA VWF
36 plasmodium vivax malaria 10.3 ANGPT2 IL6 TNF
37 meconium aspiration syndrome 10.3 EDN1 IL6 TNF
38 mesangial proliferative glomerulonephritis 10.3 EDN1 FGF2 IL6
39 diffuse meningeal melanocytosis 10.3 EDN1 HGF
40 takayasu arteritis 10.2 IL6 TNF VWF
41 apnea, obstructive sleep 10.2 EDN1 IL6 TNF
42 complex regional pain syndrome 10.2 EDN1 IL6 TNF
43 pericardial effusion 10.2 FGF2 HIF1A IL6 VEGFA
44 angiomatous meningioma 10.2 FGF2 KDR VEGFA
45 clear cell renal cell carcinoma 10.2 HIF1A KDR VEGFA
46 capillary hemangioma 10.2 KDR TEK VEGFA
47 dry eye syndrome 10.2 FGF2 HGF IL6 TNF
48 parasitic protozoa infectious disease 10.2 IL6 KDR TNF
49 endometritis 10.2 IL6 PGF TNF
50 kaposi sarcoma 10.2 FGF2 IL6 TNF VEGFA

Graphical network of the top 20 diseases related to Limb Ischemia:



Diseases related to Limb Ischemia

Symptoms & Phenotypes for Limb Ischemia

MGI Mouse Phenotypes related to Limb Ischemia:

43 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.46 HIF1A EDN1 ACE FGF2 ANGPT2 HGF
2 cellular MP:0005384 10.29 HGF CXCL12 FGF2 ANGPT2 IL6 NOS3
3 homeostasis/metabolism MP:0005376 10.29 EDN1 ACE FGF2 ANGPT2 IL6 NOS3
4 mortality/aging MP:0010768 10.28 CXCL12 HIF1A EDN1 ACE FGF2 ANGPT2
5 hematopoietic system MP:0005397 10.27 CXCL12 HIF1A ACE FGF2 HGF IL6
6 growth/size/body region MP:0005378 10.25 HGF EDN1 ACE NOS3 IL6 HIF1A
7 immune system MP:0005387 10.2 CXCL12 ACE ANGPT2 IL6 NOS3 HIF1A
8 digestive/alimentary MP:0005381 10.14 EDN1 ANGPT2 IL6 NOS3 HIF1A VEGFA
9 embryo MP:0005380 10.13 HGF EDN1 HIF1A KDR VEGFA TNF
10 muscle MP:0005369 10.11 HIF1A EDN1 FGF2 CXCL12 KDR IL6
11 liver/biliary system MP:0005370 10.09 CXCL12 HIF1A ACE HGF IL6 NOS3
12 nervous system MP:0003631 10 CXCL12 EDN1 FGF2 IL6 NOS3 HIF1A
13 neoplasm MP:0002006 9.87 ACE FGF2 IL6 HIF1A VEGFA TNF
14 respiratory system MP:0005388 9.81 ANGPT2 IL6 NOS3 PGF HIF1A KDR
15 skeleton MP:0005390 9.56 EDN1 FGF2 NOS3 IL6 HIF1A KDR
16 vision/eye MP:0005391 9.32 HIF1A FGF2 ANGPT2 IL6 NOS3 PGF

Drugs & Therapeutics for Limb Ischemia

Drugs for Limb Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 211)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 50-78-2 2244
2
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
3
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
5
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
6
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
7
Iodine Approved, Investigational Phase 4 7553-56-2 807
8
Metronidazole Approved Phase 4 443-48-1 4173
9
Povidone Approved Phase 4 9003-39-8
10
Povidone-iodine Approved Phase 4 25655-41-8
11
Teicoplanin Approved, Investigational Phase 4 61036-62-2
12
Ephedrine Approved Phase 4 299-42-3 9294
13
Norepinephrine Approved Phase 4 51-41-2 439260
14
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
15
Phenylephrine Approved Phase 4 59-42-7 6041
16
Pseudoephedrine Approved Phase 4 90-82-4 7028
17
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3 33069-62-4 36314
18
Clopidogrel Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 120202-66-6, 113665-84-2 60606
19
Ticlopidine Approved Phase 4,Phase 2 55142-85-3 5472
20
Lenograstim Approved, Investigational Phase 4,Phase 1,Phase 2,Early Phase 1 135968-09-1
21
Alprostadil Approved, Investigational Phase 4,Phase 2 745-65-3 149351
22
Ramipril Approved Phase 4 87333-19-5 5362129
23
Cilostazol Approved, Investigational Phase 4,Phase 2 73963-72-1 2754
24
Zinc Approved, Investigational Phase 4 7440-66-6 32051 23994
25
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
26
Insulin Glargine Approved Phase 4 160337-95-1
27
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
28 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
29 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Early Phase 1
30 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Early Phase 1
31 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Early Phase 1
32 Antipyretics Phase 4,Phase 3,Phase 2,Early Phase 1
33 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
34 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
35 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
36 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
37 Platelet Aggregation Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
38 Anti-Anxiety Agents Phase 4
39 Anticonvulsants Phase 4
40 calcium channel blockers Phase 4
41 Calcium, Dietary Phase 4,Phase 2,Early Phase 1
42 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1
43 Psychotropic Drugs Phase 4
44 Tranquilizing Agents Phase 4
45 Amoxicillin-Potassium Clavulanate Combination Phase 4
46 Anti-Bacterial Agents Phase 4,Phase 2
47 Antibiotics, Antitubercular Phase 4,Phase 2
48 Anti-Infective Agents Phase 4,Phase 2
49 Anti-Infective Agents, Local Phase 4
50 Antiparasitic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 402)

# Name Status NCT ID Phase Drugs
1 Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia Unknown status NCT01104441 Phase 4
2 Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia Unknown status NCT00403780 Phase 4 pregabalin;placebo
3 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part II) (DCLI-II) Unknown status NCT01173094 Phase 4
4 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part I) Unknown status NCT01171703 Phase 4
5 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
6 The Amputation Surgical Site Infection Trial (ASSIT) Unknown status NCT02018094 Phase 4 Co-amoxiclav;Iodine;Metronidazole;Chlorhexidine;Teicoplanin;Clindamycin
7 Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery Unknown status NCT01147419 Phase 4
8 A Pilot Trial of Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients Unknown status NCT02203630 Phase 4 Phenylephrine;Norepinephrine
9 Self Expanding Nitinol Stent Versus Percutaneous Transluminal Arterial Angioplasty (PTA) With Optional Bailout Stenting in Case of PTA Failure in Patients With Symptomatic Critical Limb Ischemia or Severe Intermittent Claudication (EXPAND) Completed NCT00906022 Phase 4
10 Non-Interventional Post Marketing Surveillance Study of Neovasculgen® in Patients With Chronic Lower Limb Ischemia Completed NCT02369809 Phase 4 Neovasculgen®
11 Drug Eluting Balloon in peripherAl inTErvention For Below The Knee Angioplasty Evaluation Completed NCT01558505 Phase 4
12 Cryoplasty CLIMB-registry Completed NCT00459888 Phase 4
13 Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE) Completed NCT00883246 Phase 4
14 Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV Completed NCT00596752 Phase 4 Alprostadil
15 DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions Completed NCT00637741 Phase 4
16 Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp) Completed NCT00300690 Phase 4
17 Efficacy Study of Iliac Stents to Treat TASC A-B-C-D Iliac Artery Lesions Completed NCT00764777 Phase 4
18 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
19 Protective Effects of L-arginine During Reperfusion by Femoropopliteal Bypass for Lower Limb Ischemic Syndrome in Humans Completed NCT02117206 Phase 4 L-arginine (L-arginine Veyron);Nacl
20 Prevention of Ischemic Events in Patients With Peripheral Arterial Disease Completed NCT00761969 Phase 4
21 Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery Completed NCT01427621 Phase 4
22 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
23 Clinical and Cost Effectiveness of ACE Inhibitor, Ramipril, in Intermittent Claudicants Completed NCT01037530 Phase 4 Ramipril
24 The Study to Compare SMART Nitinol Stent and Balloon Angioplasty Completed NCT00309595 Phase 4
25 The Study to Compare the Cordis SMART™ Stent System With the Bard® Luminexx™ Stent Completed NCT00235131 Phase 4
26 Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia Recruiting NCT02563535 Phase 4
27 Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging Recruiting NCT02807779 Phase 4 Dexamethasone infusion
28 Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery Recruiting NCT02085551 Phase 4
29 Clinical Study of the Aorta-femoral Bypass and Hybrid Intervention and the Iliac Arteries With Stenting and Plasty of the Common Femoral Artery Effectiveness in Patients With the Iliac Segment and Femoral Artery Occlusive Disease (TASC C, D) Active, not recruiting NCT02580084 Phase 4
30 Effectiveness of Adventitial Dexamethasone in Peripheral Artery Disease Active, not recruiting NCT01983449 Phase 4 Dexamethasone Sodium Phosphate Injection, USP
31 Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study) Not yet recruiting NCT02829151 Phase 4 Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) );Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel;Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol
32 Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia Terminated NCT00504088 Phase 4
33 Normalization of Fasting Glucose and the Incidence of Restenosis After Peripheral Angioplasty Terminated NCT01150617 Phase 4 Insulin glargine plus insulin analogues
34 Use Art-assist and Neupogen to Treat Chronic Limb Ischemia Withdrawn NCT02408991 Phase 4 Neupogen
35 Treatment of Chronic Critical Limb Ischemia With G-CSF-mobilized Autologous Peripheral Blood Mononuclear Cells Unknown status NCT01833585 Phase 3
36 Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia Unknown status NCT00539266 Phase 2, Phase 3
37 VADOplex Critical Limb Ischemia Study Unknown status NCT02034539 Phase 2, Phase 3
38 Distal Venous Arterialisation of Ischemic Limb Unknown status NCT01211925 Phase 2, Phase 3 Aspirin
39 Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia Unknown status NCT00434616 Phase 2, Phase 3
40 Transfer of Cardioprotection During RIPC Unknown status NCT01956708 Phase 2, Phase 3
41 Pain and Music Therapy in Patients Suffering Arteritis Unknown status NCT01323504 Phase 3
42 NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
43 An Efficacy and Safety Study of Ixmyelocel-T in Patients With Critical Limb Ischemia (CLI) Completed NCT01483898 Phase 3
44 Bone Marrow Aspirate Concentrate (BMAC) for Treatment of Critical Limb Ischemia (CLI) Completed NCT01245335 Phase 3
45 Bone Marrow Autograft in Limb Ischemia Completed NCT00904501 Phase 3
46 Efficacy and Safety of XRP0038/NV1FGF in Critical Limb Ischemia Patients With Skin Lesions Completed NCT00566657 Phase 3
47 Monocentric Trial: Stem Cell Emergency Life Threatening Limbs Arteriopathy (SCELTA) Completed NCT02454231 Phase 2, Phase 3
48 Drug Eluting Stents In The Critically Ischemic Lower Leg 2 Completed NCT01442636 Phase 2, Phase 3
49 Single Arm Study With a Nitinol Self-Expanding Paclitaxel-Eluting Stent to Treat BTK Arteries Completed NCT01630070 Phase 2, Phase 3
50 Prevention of Autogenous Vein Graft Failure in Peripheral Artery Bypass Procedures Completed NCT00041925 Phase 2, Phase 3 CGT003 (E2F Duplex Decoy)

Search NIH Clinical Center for Limb Ischemia

Genetic Tests for Limb Ischemia

Anatomical Context for Limb Ischemia

MalaCards organs/tissues related to Limb Ischemia:

38
Bone, Bone Marrow, Kidney, Heart, Endothelial, Liver, Brain

Publications for Limb Ischemia

Articles related to Limb Ischemia:

(show top 50) (show all 815)
# Title Authors Year
1
Acute Limb Ischemia-Much More Than Just a Lack of Oxygen. ( 29373539 )
2018
2
Endovascular Distal Plantar Vein Arterialization in Dialysis Patients With No-Option Critical Limb Ischemia and Posterior Tibial Artery Occlusion: A Technique for Limb Salvage in a Challenging Patient Subset. ( 29264998 )
2018
3
Rationale and design of the Clinical and Histologic Analysis of Mesenchymal Stromal Cells in AmPutations (CHAMP) trial investigating the therapeutic mechanism of mesenchymal stromal cells in the treatment of critical limb ischemia. ( 29395424 )
2018
4
The Incidence, Risk Factors, and Outcomes of Contrast-Induced Nephropathy In Patients With Critical Limb Ischemia Following Lower Limb Angiography. ( 29390867 )
2018
5
Long-Term Clinical Outcomes Survey of Bone Marrow-Derived Cell Therapy in Critical Limb Ischemia in Japan. ( 29386474 )
2018
6
Natural language processing of clinical notes for identification of critical limb ischemia. ( 29425639 )
2018
7
Rationale and design of the SAIL trial for intramuscular injection of allogeneic mesenchymal stromal cells in no-option critical limb ischemia. ( 29242062 )
2018
8
Spinal Cord Stimulation Improves the Microvascular Perfusion Insufficiency Caused by Critical Limb Ischemia. ( 29377343 )
2018
9
Clinical Outcomes after Isolated Infrapopliteal Revascularization in Hemodialysis Patients with Critical Limb Ischemia: Endovascular Therapy versus Bypass Surgery. ( 29367521 )
2018
10
Acute Limb Ischemia Secondary to Native Artery Occlusion: Results of a Contemporary Case Series. ( 29404750 )
2018
11
Efficacy Outcomes of Endovascular Versus Surgical Revascularization in Critical Limb Ischemia: Results From a Prospective Cohort Study. ( 29355026 )
2018
12
Cryptogenic acute limb ischemia: a retrospective cohort study defining a previously undescribed clinical entity. ( 29357035 )
2018
13
The influence of patients' nutritional status on the prevalence, course and treatment outcomes of lower limb ischemia: an overview of current evidence. ( 29385791 )
2018
14
The Role of miR-126 in Critical Limb Ischemia Treatment Using Adipose-Derived Stem Cell Therapeutic Factor Concentrate and Extracellular Matrix Microparticles. ( 29371587 )
2018
15
Effects of C1 inhibitor on endothelial cell activation in a rat hind limb ischemia-reperfusion injury model. ( 29395422 )
2018
16
Successful limb salvage from critical limb ischemia with bilateral variant anatomy of infrapopliteal arteries. ( 29275511 )
2017
17
Association between statin therapy and amputation-free survival in patients with critical limb ischemia in the CRITISCH registry. ( 28807382 )
2017
18
Decision-Making in Critical Limb Ischemia: A Markov Simulation. ( 28739455 )
2017
19
Fractional flow reserve in below the knee arteries with critical limb ischemia and validation against gold-standard morphologic, functional measures and long term clinical outcomes. ( 28866449 )
2017
20
Limb Ischemia after Heart Transplantation: An Unusual Case of Tissue Embolism. ( 28828026 )
2017
21
Inframalleolar Interventions in Critical Limb Ischemia: Trailblazing the Path Toward the Final Frontier? ( 28057290 )
2017
22
Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia. ( 28397742 )
2017
23
A pro-angiogenic degradable Mg-poly(lactic-co-glycolic acid) implant combined with rhbFGF in a rat limb ischemia model. ( 28951330 )
2017
24
Thrombolytic therapy for critical limb ischemia in a Jehovah's Witness with severe anemia. ( 29349406 )
2017
25
Letter by Czihal and Hoffmann Regarding Article, "Prevalence of Tibial Artery and Pedal Arch Patency by Angiography in Patients With Critical Limb Ischemia and Noncompressible Ankle Brachial Index". ( 28916606 )
2017
26
Alteration of sarcoplasmic reticulum Ca2+ ATPase expression in lower limb ischemia caused by atherosclerosis obliterans. ( 28648117 )
2017
27
Prevalence and Impact of Critical Limb Ischemia on In-Hospital Outcome in Transcatheter Aortic Valve Implantation in Germany. ( 28870876 )
2017
28
Blockade of HMGB1 preserves vascular homeostasis and improves blood perfusion in rats of acute limb ischemia/reperfusion. ( 28228367 )
2017
29
Occlusive Shrinkage of Ovation Endograft Presenting as Acute Lower Limb Ischemia: Effective Endovascular Management. ( 28868311 )
2017
30
Predictive Parameters for Clinical Outcome in Patients with Critical Limb Ischemia Who Underwent Percutaneous Transluminal Angioplasty (PTA): A Systematic Review. ( 28924874 )
2017
31
Biodegradable Carriers for Delivery of VEGF Plasmid DNA for the Treatment of Critical Limb Ischemia. ( 28848442 )
2017
32
Risk of major amputation or death among patients with critical limb ischemia initially treated with endovascular intervention, surgical bypass, minor amputation, or conservative management. ( 28760065 )
2017
33
The Effect of Charcot Neuroarthropathy on Limb Preservation in Diabetic Patients with Foot Wound and Critical Limb Ischemia after Balloon Angioplasty. ( 28951878 )
2017
34
Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia. ( 27853042 )
2017
35
Surgical Interventions for Organ and Limb Ischemia Associated With Primary and Secondary Antiphospholipid Antibody Syndrome With Arterial Involvement. ( 28920529 )
2017
36
Catheter directed thrombolysis is not limited to acute limb ischemia treatment- the experience from vascular surgery division. ( 28849898 )
2017
37
A nationwide analysis of 30-day readmissions related to critical limb ischemia. ( 28836900 )
2017
38
A Molecular and Clinical Review of Stem Cell Therapy in Critical Limb Ischemia. ( 29358955 )
2017
39
Reduced amputation rate with isovolemic hemodilution in critical limb ischemia patients. ( 28922142 )
2017
40
Popliteal artery entrapment syndrome presenting as acute limb ischemia in pregnancy. ( 29349433 )
2017
41
Moderate Exercise Allows for shorter Recovery Time in Critical Limb Ischemia. ( 28790926 )
2017
42
Administration of FTY720 during Tourniquet-Induced Limb Ischemia Reperfusion Injury Attenuates Systemic Inflammation. ( 29410598 )
2017
43
Switch to Ticagrelor in critical limb ischemia antiplatelet study (STT-CLIPS). ( 29329963 )
2017
44
Association Between Preoperative Frailty and Mortality in Patients With Critical Limb Ischemia Following Infrainguinal Bypass Surgerya88- Usefulness of the Barthel Index. ( 28835590 )
2017
45
High and immeasurable ankle-brachial index as predictor ofA poor amputation-free survival in critical limb ischemia. ( 29290494 )
2017
46
Association of arterial calcification with chronic limb ischemia in patients with peripheral artery disease. ( 28870682 )
2017
47
Long-Term Outcomes of Successful Endovascular Therapy Via the Retrograde Approach for Below-the-Knee Chronic Total Occlusion in Patients With Critical Limb Ischemia After a Failed Antegrade Approach. ( 28045669 )
2017
48
Characteristics and clinical outcomes of repeat endovascular therapy after infrapopliteal balloon angioplasty in patients with critical limb ischemia. ( 28799724 )
2017
49
Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes. ( 28900239 )
2017
50
Comparison of drug eluting balloon angioplasty to infrapopliteal artery critical lesions with or without additional pedal artery angioplasty in patients with diabetes mellitus and critical limb ischemia. ( 29250834 )
2017

Variations for Limb Ischemia

Expression for Limb Ischemia

Search GEO for disease gene expression data for Limb Ischemia.

Pathways for Limb Ischemia

Pathways related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.17 CXCL12 EDN1 FGF2 HGF HIF1A IL6
2
Show member pathways
13.82 ANGPT2 CXCL12 FGF2 HGF HIF1A IL6
3
Show member pathways
13.72 CXCL12 FGF2 HGF IL6 KDR NOS3
4
Show member pathways
13.68 ANGPT2 CXCL12 EDN1 HGF IL6 KDR
5
Show member pathways
13.57 CXCL12 FGF2 HGF IL6 KDR NOS3
6
Show member pathways
13.56 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
7
Show member pathways
13.48 FGF2 HGF KDR TEK TNF VEGFA
8
Show member pathways
13.38 FGF2 HGF HIF1A IL6 TEK TNF
9
Show member pathways
13.34 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
10
Show member pathways
13.33 CXCL12 FGF2 HGF IL6 KDR PGF
11
Show member pathways
13.31 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
12
Show member pathways
13.2 CXCL12 FGF2 HGF IL6 KDR NOS3
13
Show member pathways
13.08 CXCL12 FGF2 HGF IL6 KDR PGF
14
Show member pathways
13.07 ACE CXCL12 FGF2 HGF HIF1A IL6
15
Show member pathways
12.88 HGF KDR PGF VEGFA VWF
16 12.87 CXCL12 FGF2 HGF HIF1A IL6 PGF
17
Show member pathways
12.75 ANGPT2 FGF2 HGF KDR PGF TEK
18
Show member pathways
12.72 ANGPT2 FGF2 HGF IL6 KDR NOS3
19
Show member pathways
12.71 CXCL12 FGF2 HGF IL6 KDR PGF
20 12.67 ANGPT2 FGF2 HGF KDR PGF TEK
21
Show member pathways
12.65 ANGPT2 FGF2 IL6 NOS3 TEK TNF
22
Show member pathways
12.63 ANGPT2 FGF2 HIF1A IL6 TNF VEGFA
23
Show member pathways
12.38 KDR NOS3 PGF VEGFA
24 12.29 FGF2 HGF HIF1A KDR TNF VEGFA
25
Show member pathways
12.25 FGF2 KDR NOS3 VEGFA
26
Show member pathways
12.23 ACE IL6 TNF TNNI3
27 12.2 HIF1A IL6 TNF VEGFA
28 12.15 EDN1 KDR NOS3 TNF VEGFA
29 12.14 ANGPT2 FGF2 KDR TEK
30 12.03 FGF2 HGF IL6 KDR TNNI3 VEGFA
31 11.95 EDN1 IL6 NOS3 TNF VEGFA
32
Show member pathways
11.94 IL6 NOS3 TNF
33 11.93 EDN1 IL6 TNF
34
Show member pathways
11.9 HIF1A KDR NOS3 PGF VEGFA
35 11.9 FGF2 HGF HIF1A IL6 TNF VEGFA
36 11.88 FGF2 IL6 TNNI3
37 11.88 CXCL12 IL6 TEK TNF VEGFA
38 11.8 ANGPT2 EDN1 HIF1A IL6 NOS3 TEK
39 11.76 CXCL12 EDN1 HIF1A VEGFA
40
Show member pathways
11.69 IL6 TNF VEGFA
41 11.67 EDN1 FGF2 HGF IL6 TNF
42 11.66 EDN1 HIF1A NOS3 VEGFA
43 11.6 FGF2 KDR TNNI3
44 11.6 FGF2 HGF IL6 VEGFA
45 11.58 HIF1A IL6 VEGFA
46 11.56 FGF2 KDR VEGFA
47 11.56 HGF IL6 TNF
48 11.52 FGF2 KDR VEGFA
49
Show member pathways
11.48 HGF KDR VEGFA
50 11.48 FGF2 KDR VEGFA

GO Terms for Limb Ischemia

Cellular components related to Limb Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
2 extracellular region GO:0005576 9.44 ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
3 platelet alpha granule lumen GO:0031093 9.43 HGF VEGFA VWF
4 Weibel-Palade body GO:0033093 9.16 EDN1 VWF

Biological processes related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.98 HIF1A KDR TNF VEGFA
2 extracellular matrix organization GO:0030198 9.97 FGF2 KDR TNF VWF
3 regulation of receptor activity GO:0010469 9.97 CXCL12 EDN1 FGF2 HGF IL6 PGF
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 FGF2 KDR TEK TNF
5 peptidyl-tyrosine phosphorylation GO:0018108 9.93 FGF2 HGF KDR TEK
6 positive regulation of cell migration GO:0030335 9.93 CXCL12 EDN1 HGF KDR VEGFA
7 positive regulation of protein phosphorylation GO:0001934 9.92 KDR TEK TNF VEGFA
8 positive regulation of protein kinase B signaling GO:0051897 9.91 FGF2 HGF TEK TNF
9 activation of MAPK activity GO:0000187 9.89 FGF2 HGF TNF
10 positive regulation of DNA binding transcription factor activity GO:0051091 9.89 EDN1 IL6 TNF
11 cellular response to hypoxia GO:0071456 9.89 EDN1 HIF1A VEGFA
12 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.88 HGF IL6 VEGFA
13 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.87 IL6 TNF VEGFA
14 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.86 KDR PGF VEGFA
15 regulation of blood pressure GO:0008217 9.86 ACE EDN1 NOS3
16 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.86 HGF KDR TEK
17 vasculogenesis GO:0001570 9.84 KDR TNNI3 VEGFA
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.84 EDN1 IL6 TNF
19 positive regulation of cell adhesion GO:0045785 9.81 CXCL12 TNF VEGFA
20 positive regulation of cell division GO:0051781 9.8 FGF2 PGF VEGFA
21 positive regulation of MAP kinase activity GO:0043406 9.8 EDN1 FGF2 TNF VEGFA
22 response to hypoxia GO:0001666 9.8 ANGPT2 CXCL12 EDN1 HIF1A PGF TEK
23 positive regulation of endothelial cell migration GO:0010595 9.78 EDN1 KDR TEK VEGFA
24 blood vessel morphogenesis GO:0048514 9.76 ANGPT2 EDN1 HIF1A
25 animal organ regeneration GO:0031100 9.76 ANGPT2 CXCL12 HGF PGF
26 angiogenesis GO:0001525 9.76 ANGPT2 FGF2 HIF1A KDR NOS3 PGF
27 positive regulation of focal adhesion assembly GO:0051894 9.73 KDR TEK VEGFA
28 positive chemotaxis GO:0050918 9.73 CXCL12 FGF2 HGF VEGFA
29 embryonic hemopoiesis GO:0035162 9.72 HIF1A KDR
30 positive regulation of chemokine production GO:0032722 9.72 HIF1A IL6 TNF
31 positive regulation of blood vessel endothelial cell migration GO:0043536 9.72 FGF2 HIF1A KDR NOS3 VEGFA
32 heart contraction GO:0060047 9.71 ACE TNNI3
33 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.71 HIF1A VEGFA
34 positive regulation of positive chemotaxis GO:0050927 9.71 KDR VEGFA
35 neutrophil mediated immunity GO:0002446 9.7 ACE IL6
36 cell migration involved in sprouting angiogenesis GO:0002042 9.7 FGF2 KDR VEGFA
37 negative regulation of lipid storage GO:0010888 9.69 IL6 TNF
38 induction of positive chemotaxis GO:0050930 9.69 CXCL12 PGF VEGFA
39 positive regulation of receptor biosynthetic process GO:0010870 9.68 EDN1 HIF1A
40 positive regulation of axon extension involved in axon guidance GO:0048842 9.67 CXCL12 VEGFA
41 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.65 EDN1 NOS3
42 positive regulation of mast cell chemotaxis GO:0060754 9.65 PGF VEGFA
43 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.65 ACE VEGFA
44 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.64 KDR VEGFA
45 glomerulus vasculature development GO:0072012 9.62 ANGPT2 TEK
46 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.61 HIF1A VEGFA
47 Tie signaling pathway GO:0048014 9.59 ANGPT2 TEK
48 positive regulation of chemokine-mediated signaling pathway GO:0070101 9.58 EDN1 HIF1A
49 positive regulation of endothelial cell proliferation GO:0001938 9.5 CXCL12 FGF2 HIF1A KDR PGF TEK
50 positive regulation of angiogenesis GO:0045766 9.28 ANGPT2 FGF2 HGF HIF1A KDR NOS3

Molecular functions related to Limb Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.62 FGF2 HGF KDR TEK
2 chemoattractant activity GO:0042056 9.46 CXCL12 FGF2 HGF VEGFA
3 cytokine activity GO:0005125 9.43 CXCL12 EDN1 FGF2 IL6 TNF VEGFA
4 vascular endothelial growth factor receptor binding GO:0005172 9.26 PGF VEGFA
5 growth factor activity GO:0008083 9.1 CXCL12 FGF2 HGF IL6 PGF VEGFA

Sources for Limb Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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36 KEGG
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41 MeSH
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43 MGI
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50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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