MCID: LMB062
MIFTS: 48

Limb Ischemia malady

Categories: Cardiovascular diseases

Aliases & Classifications for Limb Ischemia

Aliases & Descriptions for Limb Ischemia:

Name: Limb Ischemia 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050852

Summaries for Limb Ischemia

MalaCards based summary : Limb Ischemia is related to critical limb ischemia and intermittent claudication. An important gene associated with Limb Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Aspirin and Pregabalin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and endothelial, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Limb Ischemia

Diseases related to Limb Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)
id Related Disease Score Top Affiliating Genes
1 critical limb ischemia 12.4
2 intermittent claudication 11.1
3 ischemia 11.0
4 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
5 vogt-koyanagi-harada disease 10.3 IL6 TNF VEGFA
6 artery disease 10.3
7 leukoplakia of vagina 10.3 IL6 TNF VEGFA
8 ectodermal dysplasia bartalos type 10.3 IL6 TNF VEGFA
9 retinal degeneration 10.3 IL6 TEK VEGFA
10 endotheliitis 10.3
11 pituitary infarct 10.2 IL6 TEK VEGFA
12 renal adenoma 10.2 TNF VEGFA VWF
13 dextrocardia 10.2 IL6 TNF VWF
14 craniosynostosis, type 1 10.2 IL6 VEGFA
15 isolated anterior cervical hypertrichosis 10.2 HIF1A VEGFA
16 spondylolysis 10.2 IL6 TNF VEGFA
17 ulcerative proctitis 10.2 CCL2 TNF VEGFA
18 intracranial cysts 10.2 NOS3 VEGFA
19 steroid dehydrogenase deficiency dental anomalies 10.2 CCL2 IL6 TNF
20 scar contracture 10.2 CCL2 IL6 VEGFA
21 proliferating trichilemmal cyst 10.2 EDN1 NOS3
22 anal paget's disease 10.2 FGF2 IL6 TNF
23 bladder signet ring cell adenocarcinoma 10.2 CCL2 IL6 TNF
24 choanal atresia, bilateral 10.2 CCL2 IL6 TNF
25 motility-related diarrhea 10.2 CCL2 IL6 TNF
26 tooth erosion 10.2 FGF2 VEGFA VWF
27 atrophy of prostate 10.2 CCL2 IL6 TNF
28 pemphigus vulgaris, familial 10.2 IL6 TNF VWF
29 infancy electroclinical syndrome 10.2 CCL2 IL6 TNF
30 peripheral artery disease 10.2
31 esophagus lymphoma 10.2 EDN1 IL6 TNF
32 baritosis 10.2 CCL2 IL6 TNF
33 amelogenesis imperfecta 10.2 CCL2 IL6 TNF
34 nasal cavity cancer 10.2 FGF2 HGF TNF
35 anterograde amnesia 10.2 FGF2 IL6 VEGFA
36 dyslexia 5 10.2 IL6 TNF
37 preaxial polydactyly of fingers 10.2 ACE IL6 TNF
38 neovascular glaucoma 10.2 CCL2 IL6 TNF
39 vesiculobullous skin disease 10.2 KDR TEK VEGFA
40 human venous malformation 10.2 NOS3 VEGFA VWF
41 ectodermal dysplasia 9, hair/nail type 10.2 EDN1 NOS3 VEGFA
42 sclerosing adenosis of breast 10.2 CCL2 IL6 TNF
43 neonatal jaundice 10.1 CCL2 IL6 TNF
44 spinocerebellar ataxia 25 10.1 IL6 KDR VEGFA
45 secretory diarrhea myopathy and deafness 10.1 ACE IL6 VWF
46 pigmentation disease 10.1 CCL2 IL6 TNF
47 capillary hemangioma 10.1 EDN1 NOS3 VEGFA
48 bare lymphocyte syndrome, type i 10.1 CCL2 IL6 TNF
49 alcoholic hepatitis 10.1 ACE IL6 TNF
50 bone angioendothelial sarcoma 10.1 CCL2 IL6 TNF

Graphical network of the top 20 diseases related to Limb Ischemia:



Diseases related to Limb Ischemia

Symptoms & Phenotypes for Limb Ischemia

MGI Mouse Phenotypes related to Limb Ischemia:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.4 NOS3 PGF TEK TNF VEGFA VWF
2 hematopoietic system MP:0005397 10.27 HIF1A IL6 KDR NOS3 TEK TNF
3 homeostasis/metabolism MP:0005376 10.26 IL6 KDR NOS3 PGF TEK TNF
4 cellular MP:0005384 10.25 CXCL12 FGF2 HGF HIF1A IL6 KDR
5 growth/size/body region MP:0005378 10.25 ACE EDN1 HGF HIF1A IL6 KDR
6 mortality/aging MP:0010768 10.22 ACE CXCL12 EDN1 FGF2 HGF HIF1A
7 immune system MP:0005387 10.2 ACE CCL2 CXCL12 HIF1A IL6 KDR
8 embryo MP:0005380 10.13 HIF1A KDR PGF TEK TNF VEGFA
9 liver/biliary system MP:0005370 10.09 ACE CXCL12 HGF HIF1A IL6 KDR
10 digestive/alimentary MP:0005381 10.08 VWF EDN1 HIF1A IL6 NOS3 TNF
11 muscle MP:0005369 10.07 CXCL12 EDN1 FGF2 HIF1A IL6 KDR
12 nervous system MP:0003631 10 CXCL12 EDN1 FGF2 HIF1A IL6 KDR
13 neoplasm MP:0002006 9.87 ACE FGF2 HIF1A IL6 PGF TNF
14 respiratory system MP:0005388 9.7 HIF1A IL6 KDR NOS3 PGF TNF
15 skeleton MP:0005390 9.56 EDN1 FGF2 HIF1A IL6 KDR NOS3
16 vision/eye MP:0005391 9.28 TNF VEGFA FGF2 HIF1A IL6 KDR

Drugs & Therapeutics for Limb Ischemia

Drugs for Limb Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 308)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 50-78-2 2244
2
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
3
Menthol Approved Phase 4,Phase 2,Phase 3,Phase 1 2216-51-5 16666
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
5
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
6
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
7
Metronidazole Approved Phase 4 443-48-1 4173
8
Povidone-iodine Approved Phase 4 25655-41-8
9
Teicoplanin Approved Phase 4 61036-62-2
10
Ephedrine Approved Phase 4 299-42-3 9294
11
Norepinephrine Approved Phase 4,Phase 3 51-41-2 439260
12
Oxymetazoline Approved Phase 4 1491-59-4 4636
13
Phenylephrine Approved Phase 4 59-42-7 6041
14
Pseudoephedrine Approved Phase 4 90-82-4 7028
15
Acetylcholine Approved Phase 4,Phase 2 51-84-3 187
16
Nitric Oxide Approved Phase 4 10102-43-9 145068
17
Dopamine Approved Phase 4,Phase 3,Early Phase 1 51-61-6, 62-31-7 681
18
Levodopa Approved Phase 4,Phase 3 59-92-7 6047
19
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
20
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3 33069-62-4 36314
21
Alprostadil Approved, Investigational Phase 4,Phase 2 745-65-3 149351
22
Dipyridamole Approved Phase 4 58-32-2 3108
23
Warfarin Approved Phase 4,Phase 3 81-81-2 6691 54678486
24
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
25
Insulin Glargine Approved Phase 4 160337-95-1
26
Lenograstim Approved Phase 4,Phase 1,Phase 2,Early Phase 1 135968-09-1
27
Ramipril Approved Phase 4 87333-19-5 5362129
28
Cilostazol Approved Phase 4,Phase 2 73963-72-1 2754
29
Tranexamic Acid Approved Phase 4 1197-18-8 5526
30
Zinc Approved Phase 4 7440-66-6 32051 23994
31
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
32
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
33
Rivaroxaban Approved Phase 4,Phase 3,Phase 2 366789-02-8
34
Vorapaxar Approved Phase 4 618385-01-6
35
Glucosamine Approved, Nutraceutical Phase 4 3416-24-8 439213
36
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 120202-66-6, 113665-84-2 60606
37
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
38
Phytonadione Approved, Nutraceutical Phase 4 84-80-0 4812 5284607
39 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
40 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Early Phase 1
41 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Early Phase 1
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Early Phase 1
43 Antipyretics Phase 4,Phase 2,Phase 3,Early Phase 1
44 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Early Phase 1
45 Cyclooxygenase Inhibitors Phase 4,Phase 2,Phase 3,Early Phase 1
46 Fibrinolytic Agents Phase 4,Phase 2,Phase 3,Early Phase 1
47 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Platelet Aggregation Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
49 Anti-Anxiety Agents Phase 4
50 Anticonvulsants Phase 4

Interventional clinical trials:

(show top 50) (show all 635)
id Name Status NCT ID Phase
1 Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia Unknown status NCT01104441 Phase 4
2 Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia Unknown status NCT00403780 Phase 4
3 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part II) (DCLI-II) Unknown status NCT01173094 Phase 4
4 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part I) Unknown status NCT01171703 Phase 4
5 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
6 The Amputation Surgical Site Infection Trial (ASSIT) Unknown status NCT02018094 Phase 4
7 Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery Unknown status NCT01147419 Phase 4
8 A Pilot Trial of Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients Unknown status NCT02203630 Phase 4
9 ATHERO: Advanced Technology Halting Early Re-Stenosis and Occlusion Unknown status NCT00407940 Phase 4
10 Botulinum Toxin A for Treatment of Catocholamine Induced Finger Necrosis Unknown status NCT01500668 Phase 4
11 Global Vascular Effects of Intermittent Pneumatic Compression-Pilot Study Unknown status NCT01064323 Phase 4
12 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4
13 A Morbidity-Mortality and Remodeling Study With Valsartan Unknown status NCT00133328 Phase 4
14 Self Expanding Nitinol Stent Versus Percutaneous Transluminal Arterial Angioplasty (PTA) With Optional Bailout Stenting in Case of PTA Failure in Patients With Symptomatic Critical Limb Ischemia or Severe Intermittent Claudication (EXPAND) Completed NCT00906022 Phase 4
15 Non-Interventional Post Marketing Surveillance Study of Neovasculgen® in Patients With Chronic Lower Limb Ischemia Completed NCT02369809 Phase 4
16 Drug Eluting Balloon in peripherAl inTErvention For Below The Knee Angioplasty Evaluation Completed NCT01558505 Phase 4
17 Cryoplasty CLIMB-registry Completed NCT00459888 Phase 4
18 Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE) Completed NCT00883246 Phase 4
19 Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV Completed NCT00596752 Phase 4
20 DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions Completed NCT00637741 Phase 4
21 Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp) Completed NCT00300690 Phase 4
22 Efficacy Study of Iliac Stents to Treat TASC A-B-C-D Iliac Artery Lesions Completed NCT00764777 Phase 4
23 Protective Effects of L-arginine During Reperfusion by Femoropopliteal Bypass for Lower Limb Ischemic Syndrome in Humans Completed NCT02117206 Phase 4
24 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
25 Prevention of Ischemic Events in Patients With Peripheral Arterial Disease Completed NCT00761969 Phase 4
26 Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery Completed NCT01427621 Phase 4
27 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
28 Clinical and Cost Effectiveness of ACE Inhibitor, Ramipril, in Intermittent Claudicants Completed NCT01037530 Phase 4
29 The Study to Compare SMART Nitinol Stent and Balloon Angioplasty Completed NCT00309595 Phase 4
30 The Study to Compare the Cordis SMART™ Stent System With the Bard® Luminexx™ Stent Completed NCT00235131 Phase 4
31 Efficacy and Safety of Qizhitongluo Capsule in the Recovery Phase of Ischemic Stroke Completed NCT01762163 Phase 4
32 Prevention of Acute Kidney Injury by Erythropoietin in Thoracic Aorta Surgery With Hypothermic Cardiac Arrest Completed NCT01369732 Phase 4
33 Arterial Inflow and Muscle Ischemia During Calf Stimulation With the Veinoplus Device Completed NCT01592812 Phase 4
34 ESPRIT: European/Australasian Stroke Prevention in Reversible Ischaemia Trial Completed NCT00161070 Phase 4
35 Comparing Angioplasty and DES in the Treatment of Subjects With Ischemic Infrapopliteal Arterial Disease Completed NCT00640770 Phase 4
36 Cilostazol in Acute Ischemic Stroke Treatment (CAIST) Completed NCT00272454 Phase 4
37 Tranexamic Acid Dosing for Total Joint Arthroplasty Completed NCT02584725 Phase 4
38 Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia Recruiting NCT02563535 Phase 4
39 Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging Recruiting NCT02807779 Phase 4
40 Drug Eluting Stent for the Management of PERipheral Arterial Disease Of the SFA (DESPERADO-SFA Study) Recruiting NCT02734836 Phase 4
41 Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery Recruiting NCT02085551 Phase 4
42 Comprehensive Reparative Therapy in Ischemic Stroke COMplex Repair in Ischemic Stroke-Arm Recruiting NCT02581371 Phase 4
43 To Assess Analgesia Provided by Continuous Sciatic Nerve Block in Patients With Hypertensive Leg Ulcer Recruiting NCT01964911 Phase 4
44 Effect on Vascular Calcification of Replacing Warfarin by Rivaroxaban With or Without VitK2 in Hemodialysis Patients Recruiting NCT02610933 Phase 4
45 Clinical Study of the Aorta-femoral Bypass and Hybrid Intervention and the Iliac Arteries With Stenting and Plasty of the Common Femoral Artery Effectiveness in Patients With the Iliac Segment and Femoral Artery Occlusive Disease (TASC C, D) Active, not recruiting NCT02580084 Phase 4
46 Effectiveness of Adventitial Dexamethasone in Peripheral Artery Disease Active, not recruiting NCT01983449 Phase 4
47 Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study) Not yet recruiting NCT02829151 Phase 4
48 Vorapaxar and Lower Extremity Bypass Grafts Not yet recruiting NCT02975583 Phase 4
49 Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia Terminated NCT00504088 Phase 4
50 Normalization of Fasting Glucose and the Incidence of Restenosis After Peripheral Angioplasty Terminated NCT01150617 Phase 4

Search NIH Clinical Center for Limb Ischemia

Genetic Tests for Limb Ischemia

Anatomical Context for Limb Ischemia

MalaCards organs/tissues related to Limb Ischemia:

39
Bone, Bone Marrow, Endothelial, Neutrophil, Skin, Skeletal Muscle, Spinal Cord

Publications for Limb Ischemia

Articles related to Limb Ischemia:

(show top 50) (show all 754)
id Title Authors Year
1
Cell therapy in critical limb ischemia: A comprehensive analysis of two cell therapy products. ( 27914820 )
2017
2
Neutrophil-to-lymphocyte ratio is effective prognostic indicator for post-amputation patients with critical limb ischemia. ( 28042626 )
2017
3
Long-Term Outcomes of Successful Endovascular Therapy Via the Retrograde Approach for Below-the-Knee Chronic Total Occlusion in Patients With Critical Limb Ischemia After a Failed Antegrade Approach. ( 28045669 )
2017
4
Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia. ( 27853042 )
2017
5
Inframalleolar Interventions in Critical Limb Ischemia: Trailblazing the Path Toward the Final Frontier? ( 28057290 )
2017
6
Cost-effectiveness analysis of initial treatment strategies for nonembolic acute limb ischemia using real word data. ( 27575302 )
2016
7
Quality of life assessment as an outcomes measure in critical limb ischemia. ( 27876523 )
2016
8
Upper limb ischemia from arterial thromboembolism: a comprehensive review of incidence, aetiology, clinical aspects, diagnostic tools, treatment options and prognosis. ( 27163247 )
2016
9
Early-phase wound healing and long-term outcomes of a selective endovascular-first approach for treating Rutherford 5 critical limb ischemia with infrainguinal lesions. ( 27091136 )
2016
10
Infective endocarditis as a rare cause for acute limb ischemia. ( 27547285 )
2016
11
Treatment of Infrapopliteal Disease in Critical Limb Ischemia: Beyond Angioplasty. ( 27162221 )
2016
12
Jean Kunlin: Correspondence and commentary regarding distalA fistulas for lower limb ischemia. ( 27986485 )
2016
13
TCT-18 Validation of Wound, Ischemia, foot Ischemia (WIFI) classification system in Japanese patients after endovascular treatment for critical limb ischemia (CLI). ( 27970366 )
2016
14
Validation of the Wound, Ischemia, foot Infection (WIfI) classification system in nondiabetic patients treated by endovascular means for critical limb ischemia. ( 26994958 )
2016
15
Below-knee endovascular interventions have better outcomes compared to open bypass for patients with critical limb ischemia. ( 27928034 )
2016
16
Augmentation of arterial blood velocity with electrostimulation in patients with critical limb ischemia unsuitable for revascularization. ( 27154976 )
2016
17
Vascular access in critical limb ischemia. ( 27157294 )
2016
18
Dementia in patients suffering from critical limb ischemia. ( 27575308 )
2016
19
Safety and efficacy of cell-based therapy on critical limb ischemia: A meta-analysis. ( 27067609 )
2016
20
Treatment of hind limb ischemia using angiogenic peptide nanofibers. ( 27182813 )
2016
21
Long-term survival of patients with critical limb ischemia treated with iloprost: response rate and predictive criteria. A retrospective analysis of 102 patients. ( 28051243 )
2016
22
Granulocyte colony-stimulating factor improves the efficacy of autologous bone marrow-derived mononuclear cell transplantation treatment for lower limb ischemia. ( 27958690 )
2016
23
Peripheral vascular intervention is better than tibial bypass for critical limb ischemia. ( 27940922 )
2016
24
Embolization of Onyx Causing Acute Limb Ischemia. ( 27554697 )
2016
25
New devices to cross chronic total occlusion in critical limb ischemia. ( 27647338 )
2016
26
Sources of Delay in the Acute Limb Ischemia Patient Pathway. ( 27531096 )
2016
27
Human Stem Cells Overexpressing miR-21 Promote Angiogenesis in Critical Limb Ischemia by Targeting CHIP to Enhance HIF-1I+ Activity. ( 26841045 )
2016
28
Risk of contrast induced nephropathy in diabetic patients affected by critical limb ischemia and diabetic foot ulcers treated by percutaneous transluminal angioplasty of lower limbs. ( 27786404 )
2016
29
Arteriographic Patterns of Atherosclerosis and the Association between Diabetes Mellitus and Ethnicity in Chronic Critical Limb Ischemia. ( 27908824 )
2016
30
Autologous bone marrow mononuclear cell therapy for critical limb ischemia is effective and durable. ( 27021379 )
2016
31
Acute and chronic anemia and short- and long-term outcome of patients with peripheral arterial disease and critical limb ischemia. ( 27021473 )
2016
32
Monitoring of Foot Oxygenation with Near-infrared Spectroscopy in Patients with Critical Limb Ischemia Undergoing Percutaneous Transluminal Angioplasty: A Pilot Study. ( 27614555 )
2016
33
Commentary on 'Monitoring of Foot Oxygenation with Near-infrared Spectroscopy in Patients with Critical Limb Ischemia Undergoing Percutaneous Transluminal Angioplasty: A Pilot Study'. ( 27641489 )
2016
34
Endovascular Therapy Versus Bypass Surgery as First-Line Treatment Strategies for Critical Limb Ischemia: Results of the Interim Analysis of the CRITISCH Registry. ( 28007205 )
2016
35
Drug-Eluting Balloon Angioplasty for Below the Knee Lesions in End Stage Renal Disease Patients with Critical Limb Ischemia: Midterm Results. ( 27910185 )
2016
36
Severe Lower Limb Ischemia by Massive Arterial Thrombosis Revealing an Acute Myeloid Leukemia Needing for Leg Amputation: Clinical and Emotional Aspects Related to the Communication with the Patient and His Family. ( 28058104 )
2016
37
The Current State of Critical Limb Ischemia: A Systematic Review. ( 27551978 )
2016
38
Medical Therapy in Peripheral Artery Disease and Critical Limb Ischemia. ( 27181397 )
2016
39
Hospital Readmissions Following Endovascular Therapy for Critical Limb Ischemia: Associations With Wound Healing, Major Adverse Limb Events, and Mortality. ( 27207964 )
2016
40
The expression profile of angiogenic genes in critical limb ischemia popliteal arteries. ( 27511996 )
2016
41
Glyoxalase-1 Overexpression Reverses Defective Proangiogenic Function of Diabetic Adipose-Derived Stem Cells in Streptozotocin-Induced Diabetic Mice Model of Critical Limb Ischemia. ( 27526702 )
2016
42
TCT-792 Non-Invasive Hemodynamics Poorly Predict Disease Severity and Response to Endovascular Therapy in Patients with Critical Limb Ischemia. ( 27970180 )
2016
43
Characteristics of responders to autologous bone marrow cell therapy for no-option critical limb ischemia. ( 27530339 )
2016
44
The Impact of Chronic Kidney Disease on Hospitalized Patients With Peripheral Arterial Disease and Critical Limb Ischemia. ( 27069108 )
2016
45
How to Treat Critical Limb Ischemia: The Critical Need for High-Grade Evidence. ( 28007206 )
2016
46
Fucoidan improves bioactivity and vasculogenic potential of mesenchymal stem cells in murine hind limb ischemia associated with chronic kidney disease. ( 27216370 )
2016
47
Endovascular Treatment of Acute Aortic Occlusion with Critical Limb Ischemia using an Angiojet device. ( 27522976 )
2016
48
New treatment possibilities for patients with advanced coronary artery disease and critical limb ischemia - a feasibility study. ( 27980553 )
2016
49
2014 JAPAN Critical Limb Ischemia Database (JCLIMB) Annual Report. ( 28018516 )
2016
50
A Case of True Brachial Artery Aneurysm with Severe Left Upper Limb Ischemia. ( 28031692 )
2016

Variations for Limb Ischemia

Expression for Limb Ischemia

Search GEO for disease gene expression data for Limb Ischemia.

Pathways for Limb Ischemia

Pathways related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.15 CXCL12 EDN1 FGF2 HGF HIF1A IL6
2
Show member pathways
14.01 CCL2 FGF2 HGF HIF1A IL6 NOS3
3
Show member pathways
13.85 CCL2 CXCL12 FGF2 HGF HIF1A IL6
4
Show member pathways
13.7 CXCL12 FGF2 HGF IL6 KDR NOS3
5
Show member pathways
13.65 CCL2 CXCL12 EDN1 HGF IL6 KDR
6
Show member pathways
13.55 CXCL12 FGF2 HGF IL6 KDR NOS3
7
Show member pathways
13.51 CCL2 CXCL12 FGF2 HGF IL6 KDR
8
Show member pathways
13.48 FGF2 HGF KDR TEK TNF VEGFA
9
Show member pathways
13.36 CCL2 FGF2 HGF HIF1A IL6 TEK
10
Show member pathways
13.36 CCL2 CXCL12 FGF2 HGF IL6 KDR
11
Show member pathways
13.32 CXCL12 FGF2 HGF IL6 KDR PGF
12
Show member pathways
13.28 CCL2 CXCL12 FGF2 HGF IL6 KDR
13
Show member pathways
13.2 CXCL12 FGF2 HGF IL6 KDR NOS3
14
Show member pathways
13.07 CXCL12 FGF2 HGF IL6 KDR PGF
15
Show member pathways
13.01 ACE CCL2 CXCL12 FGF2 HGF HIF1A
16
Show member pathways
12.88 HGF KDR PGF VEGFA VWF
17
Show member pathways
12.77 FGF2 HGF KDR PGF TEK VEGFA
18
Show member pathways
12.72 CXCL12 FGF2 HGF IL6 KDR PGF
19
Show member pathways
12.68 CCL2 CXCL12 KDR NOS3 VEGFA
20 12.68 CXCL12 FGF2 HGF HIF1A IL6 PGF
21
Show member pathways
12.63 CCL2 FGF2 IL6 NOS3 TEK TNF
22
Show member pathways
12.56 KDR NOS3 TNF VEGFA
23
Show member pathways
12.4 CCL2 KDR NOS3 VEGFA
24
Show member pathways
12.38 KDR NOS3 PGF VEGFA
25 12.34 FGF2 HGF IL6 KDR NOS3 PGF
26 12.31 FGF2 HGF HIF1A KDR TNF VEGFA
27
Show member pathways
12.25 FGF2 KDR NOS3 VEGFA
28 12.19 HIF1A IL6 TNF VEGFA
29 12.11 FGF2 HGF IL6 KDR VEGFA
30 12.11 CCL2 EDN1 KDR NOS3 TNF VEGFA
31 11.99 CCL2 EDN1 IL6 TNF
32
Show member pathways
11.94 IL6 NOS3 TNF
33
Show member pathways
11.91 HIF1A KDR NOS3 PGF VEGFA
34 11.91 CCL2 EDN1 IL6 NOS3 TNF VEGFA
35 11.88 EDN1 HIF1A IL6 NOS3 TEK VEGFA
36 11.86 CCL2 FGF2 HGF HIF1A IL6 TNF
37 11.8 CCL2 CXCL12 IL6 TEK TNF VEGFA
38 11.75 CXCL12 FGF2 HGF IL6 PGF
39 11.74 CXCL12 EDN1 HIF1A VEGFA
40
Show member pathways
11.68 IL6 TNF VEGFA
41 11.64 EDN1 HIF1A NOS3 VEGFA
42 11.6 CCL2 HGF IL6 TNF
43 11.6 CCL2 EDN1 FGF2 HGF IL6 TNF
44 11.58 HIF1A IL6 VEGFA
45 11.58 FGF2 HGF IL6 VEGFA
46 11.56 FGF2 KDR VEGFA
47 11.55 CCL2 IL6 TNF
48 11.52 FGF2 KDR VEGFA
49
Show member pathways
11.47 HGF KDR VEGFA
50 11.41 EDN1 HIF1A VEGFA

GO Terms for Limb Ischemia

Cellular components related to Limb Ischemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 ACE CCL2 CXCL12 EDN1 FGF2 HGF
2 external side of plasma membrane GO:0009897 9.62 ACE CXCL12 IL6 TNF
3 extracellular region GO:0005576 9.44 ACE CCL2 CXCL12 EDN1 FGF2 HGF
4 platelet alpha granule lumen GO:0031093 9.43 HGF VEGFA VWF
5 Weibel-Palade body GO:0033093 9.16 EDN1 VWF

Biological processes related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
id Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.98 FGF2 KDR TNF VWF
2 peptidyl-tyrosine phosphorylation GO:0018108 9.95 FGF2 HGF KDR TEK
3 positive regulation of protein phosphorylation GO:0001934 9.93 KDR TEK TNF VEGFA
4 regulation of cell shape GO:0008360 9.92 CCL2 IL6 KDR VEGFA
5 positive regulation of cell migration GO:0030335 9.92 CXCL12 EDN1 HGF KDR VEGFA
6 positive regulation of cell proliferation GO:0008284 9.92 CXCL12 EDN1 FGF2 HGF IL6 KDR
7 cellular response to tumor necrosis factor GO:0071356 9.91 CCL2 EDN1 IL6
8 activation of MAPK activity GO:0000187 9.91 FGF2 HGF TNF
9 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.9 EDN1 IL6 TNF
10 cellular response to hypoxia GO:0071456 9.9 EDN1 HIF1A VEGFA
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.9 HGF IL6 VEGFA
12 positive regulation of protein kinase B signaling GO:0051897 9.89 IL6 TEK TNF
13 response to wounding GO:0009611 9.89 CCL2 IL6 VWF
14 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.88 IL6 TNF VEGFA
15 response to glucocorticoid GO:0051384 9.88 CCL2 IL6 TNF
16 regulation of blood pressure GO:0008217 9.88 ACE EDN1 NOS3
17 response to mechanical stimulus GO:0009612 9.87 CCL2 CXCL12 IL6
18 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.87 HGF IL6 VEGFA
19 cell chemotaxis GO:0060326 9.87 CCL2 CXCL12 HGF
20 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.87 HGF KDR TEK
21 cellular response to interleukin-1 GO:0071347 9.87 CCL2 EDN1 HIF1A IL6
22 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 EDN1 IL6 TNF
23 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.85 CCL2 KDR PGF VEGFA
24 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 CCL2 FGF2 IL6 KDR TEK TNF
25 humoral immune response GO:0006959 9.84 CCL2 IL6 TNF
26 positive regulation of cell division GO:0051781 9.82 FGF2 PGF VEGFA
27 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 EDN1 IL6 TNF
28 positive regulation of MAP kinase activity GO:0043406 9.81 EDN1 FGF2 TNF VEGFA
29 response to amino acid GO:0043200 9.8 CCL2 EDN1 IL6
30 response to heat GO:0009408 9.8 CCL2 CXCL12 IL6 NOS3
31 response to hypoxia GO:0001666 9.8 CCL2 CXCL12 EDN1 HIF1A PGF TEK
32 lipopolysaccharide-mediated signaling pathway GO:0031663 9.79 CCL2 NOS3 TNF
33 animal organ regeneration GO:0031100 9.78 CCL2 CXCL12 HGF PGF
34 positive regulation of focal adhesion assembly GO:0051894 9.76 KDR TEK VEGFA
35 positive regulation of cell adhesion GO:0045785 9.76 CCL2 CXCL12 TNF VEGFA
36 angiogenesis GO:0001525 9.76 CCL2 FGF2 HIF1A KDR NOS3 PGF
37 positive regulation of chemokine production GO:0032722 9.75 HIF1A IL6 TNF
38 positive regulation of calcium ion import GO:0090280 9.74 CCL2 CXCL12
39 embryonic hemopoiesis GO:0035162 9.74 HIF1A KDR
40 cellular response to hepatocyte growth factor stimulus GO:0035729 9.73 HGF IL6
41 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.73 HIF1A VEGFA
42 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.73 CCL2 KDR
43 cell migration involved in sprouting angiogenesis GO:0002042 9.73 FGF2 KDR VEGFA
44 positive regulation of endothelial cell migration GO:0010595 9.73 EDN1 KDR TEK VEGFA
45 positive regulation of leukocyte migration GO:0002687 9.72 CCL2 VEGFA
46 positive regulation of positive chemotaxis GO:0050927 9.72 KDR VEGFA
47 negative regulation of hormone secretion GO:0046888 9.72 EDN1 IL6
48 neutrophil mediated immunity GO:0002446 9.71 ACE IL6
49 maternal process involved in parturition GO:0060137 9.71 CCL2 EDN1
50 negative regulation of lipid storage GO:0010888 9.71 IL6 TNF

Molecular functions related to Limb Ischemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.67 FGF2 HGF KDR TEK
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.58 FGF2 HGF TEK
3 heparin binding GO:0008201 9.56 CCL2 FGF2 PGF VEGFA
4 chemoattractant activity GO:0042056 9.46 CXCL12 FGF2 HGF VEGFA
5 growth factor activity GO:0008083 9.43 CXCL12 FGF2 HGF IL6 PGF VEGFA
6 vascular endothelial growth factor receptor binding GO:0005172 9.32 PGF VEGFA
7 cytokine activity GO:0005125 9.17 CCL2 CXCL12 EDN1 FGF2 IL6 TNF

Sources for Limb Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
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44 MGI
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48 NDF-RT
51 NINDS
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54 OMIM
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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