MCID: LMB024
MIFTS: 34

Limbic Encephalitis malady

Category: Rare diseases

Aliases & Classifications for Limbic Encephalitis

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Aliases & Descriptions for Limbic Encephalitis:

Name: Limbic Encephalitis 45 47 65

Classifications:



External Ids:

UMLS65 C0338430

Summaries for Limbic Encephalitis

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NIH Rare Diseases:45 Limbic encephalitis represents a group of autoimmune conditions characterized by inflammation of the limbic system and other parts of the brain. the cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. the symptoms typically develop over a few weeks or months, but they may evolve over a few days. limbic encephalitis is often associated with an underlying neoplasm (paraneoplastic limbic encephalitis); however some cases never have a neoplasm identified (non-paraneoplastic limbic encephalitis). delayed diagnosis is common, but improvements are being made to assist in early detection. various tests including imaging studies (mri, pet) laboratory tests (csf analysis), and tests that measure the electrical activity of the brain (eeg) may be utilized to confirm a diagnosis. treatment includes removal of the neoplasm (if identified) and immunotherapy. last updated: 4/26/2016

MalaCards based summary: Limbic Encephalitis is related to limbic encephalitis with dpp6 antibodies and classic paraneoplastic limbic encephalitis. An important gene associated with Limbic Encephalitis is GAD1 (Glutamate Decarboxylase 1), and among its related pathways are LGI-ADAM interactions and Taurine and hypotaurine metabolism. Affiliated tissues include brain, testes and breast, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:68 Limbic encephalitis is a form of encephalitis, a disease characterised by inflammation of the brain.... more...

Related Diseases for Limbic Encephalitis

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Diseases related to Limbic Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 321)
idRelated DiseaseScoreTop Affiliating Genes
1limbic encephalitis with dpp6 antibodies12.6
2classic paraneoplastic limbic encephalitis12.5
3limbic encephalitis with lgi1 antibodies12.5
4limbic encephalitis with ncmags antibodies12.5
5limbic encephalitis with nmda receptor antibodies12.5
6non-herpetic acute limbic encephalitis12.5
7posttransplant acute limbic encephalitis12.5
8limbic encephalitis with caspr2 antibodies12.5
9neuropathy, hereditary sensory and autonomic, type ii11.5
10leukemia10.5
11hepatitis10.4
12endotheliitis10.4
13breast cancer10.4
14paraneoplastic neurologic disorders10.4AMPH, ELAVL3
15lymphoma10.4
16rasmussen johnsen thomsen syndrome10.3GAD1, GSR
17hepatitis b10.3
18prostatitis10.3
19myeloid leukemia10.3
20cerebritis10.3
21neuroblastoma 410.2GAD1, GAD2
22prostate cancer10.2
23hepatocellular carcinoma10.2
24arthritis10.2
25porphyria10.2
26ischemia10.2
27purpura10.2
28peptic ulcer disease10.2
29lung disease10.2
30lupus erythematosus10.2
31glioblastoma10.2
32aneurysm10.2
33zika fever10.2GRIN2B, GSR
34neonatal diabetes mellitus10.2GAD1, GAD2
35tinea profunda10.1AMPH, GAD1, GAD2
36rheumatoid arthritis10.1
37neuroblastoma10.1
38porphyria cutanea tarda10.1
39systemic lupus erythematosus10.1
40hiv-110.1
41cystinuria10.1
42asthma10.1
43cystic fibrosis10.1
44peutz-jeghers syndrome10.1
45common variable immunodeficiency10.1
46myeloma10.1
47open-angle glaucoma10.1
48thrombotic thrombocytopenic purpura10.1
49hypoparathyroidism10.1
50varicocele10.1

Graphical network of the top 20 diseases related to Limbic Encephalitis:



Diseases related to limbic encephalitis

Symptoms for Limbic Encephalitis

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Drugs & Therapeutics for Limbic Encephalitis

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Drugs for Limbic Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AutoantibodiesPhase 2117
2
Tacrolimusapproved, investigational1023104987-11-3445643, 439492, 445647
Synonyms:
(-)-FK 506
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
104987-11-3
109581-93-3 (Hydrate)
15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,
3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
8-DEETHYL-8-[but-3-enyl]-ascomycin
AC-1182
AC1L1K7H
AC1L97GB
AC1L9IBU
AKOS005145901
Advagraf
Ambap104987-11-3
Ambap5429
BCBcMAP01_000194
BRD-K35452788-001-02-1
BSPBio-001279
BSPBio_001279
Bio-0921
Bio2_000470
Bio2_000950
C01375
C44H69NO10
CCRIS 7124
CHEBI:100924
CHEBI:61049
CHEMBL1200738
CID11158639
CID11556866
CID439492
CID445643
CID5372
CID5472317
CID6426916
CID6436007
CID6473866
CID6536850
CID6610362
CID6912836
CID9832283
CID9853905
CID9918805
CID9940643
CID9963169
CPD-10016
CPD000466356
D08556
DB00864
DivK1c_001040
FK 506
FK-506
FK5
FK506
FR 900506
FR-900506
FR900506
 
FT-0082660
Fk-506
Fujimycin
Graceptor
HMS1362O21
HMS1792O21
HMS1990O21
HMS2051C18
HMS2093M19
HMS503O21
Hecoria
IDI1_001040
IDI1_002225
K506
KBio1_001040
KBio2_000619
KBio2_003187
KBio2_005755
KBio3_001097
KBio3_001098
KBioGR_000619
KBioSS_000619
L 679934
L-679934
LCP-Tacro
LMPK04000003
LS-64247
MLS000759471
MLS001424054
Modigraf
MolPort-003-666-518
NCGC00163470-01
NCGC00163470-02
NCGC00163470-03
NCGC00163470-04
NCGC00179232-01
NChemBio.2007.16-comp1
NINDS_001040
NSC717865
Prograf
Prograf (TN)
Protopic
Protopy
S5003_Selleck
SAM001246677
SMR000466356
Tacarolimus
Tacrolimus
Tacrolimus (INN)
Tacrolimus (Prograf?)
Tacrolimus (anhydrous)
Tacrolimus Hydrate
Tacrolimus anhydrous
Tacrolimus hydrate
Tsukubaenolide
UNII-Y5L2157C4J
nchembio.2007.23-comp2
tacrolimus
tacrolimus hydrate
3
Prednisoneapproved126753-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
Juvason
 
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Perrigo Prednisone
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rayos
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
4Immunologic Factors18483
5Calcineurin Inhibitors1223
6Immunosuppressive Agents10422

Interventional clinical trials:

idNameStatusNCT IDPhase
1IVIG Treatment for Refractory Immune-Related Adult EpilepsyTerminatedNCT01545518Phase 2
2Immunotherapy of the Paraneoplastic SyndromesCompletedNCT00378326

Search NIH Clinical Center for Limbic Encephalitis

Genetic Tests for Limbic Encephalitis

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Anatomical Context for Limbic Encephalitis

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MalaCards organs/tissues related to Limbic Encephalitis:

33
Brain, Testes, Breast, Lung, Skin, Endothelial, Heart

Animal Models for Limbic Encephalitis or affiliated genes

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MGI Mouse Phenotypes related to Limbic Encephalitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.0ADAM22, AMPH, BRSK2, ELAVL3, GAD1, GAD2
2MP:00053866.7ADAM22, AMPH, BRSK2, ELAVL3, GAD1, GAD2

Publications for Limbic Encephalitis

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Articles related to Limbic Encephalitis:

(show top 50)    (show all 420)
idTitleAuthorsYear
1
Topiramate as a rare cause of reversible Fanconi syndrome and acute kidney injury: a case report and literature review. (26908388)
2016
2
Capillaroscopic findings in a case of Hajdu-Cheney syndrome. (26400009)
2015
3
Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia. (24940743)
2014
4
Elevation of miR-221 and -222 in the internal mammary arteries of diabetic subjects and normalization with metformin. (23648338)
2013
5
Cerebrospinal fluid PKR level predicts cognitive decline in Alzheimer's disease. (23320095)
2013
6
Association between ADAM33 S2 and ST+4 polymorphisms and susceptibility to asthma: a meta-analysis. (23612257)
2013
7
Cognitive adaptation to nonmelanoma skin cancer. (23844920)
2013
8
Spinal cord infarction is an unusual complication of intracranial neuroendovascular intervention. (24355157)
2013
9
Imported melioidosis in France revealed by a cracking abdominal mycotic aortic aneurysm in a 61-year-old man. (22962397)
2012
10
Adenoid cystic carcinoma of the base of the tongue: Late metastasis to the pancreas. (22096672)
2011
11
Association between XPD Lys751Gln polymorphism and risk of head and neck cancer: a meta-analysis. (22179996)
2011
12
Histiocytic sarcoma transdifferentiated from follicular lymphoma presenting as a cutaneous tumor. (21883369)
2011
13
We should not hesitate to use beta-blockers for systolic heart failure with concomitant renal dysfunction. (20647630)
2010
14
Brain fatty acid-binding protein and omega-3/omega-6 fatty acids: mechanistic insight into malignant glioma cell migration. (20834042)
2010
15
The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression. (19385048)
2009
16
Endometrial claudin-4 and leukemia inhibitory factor are associated with assisted reproduction outcome. (19374770)
2009
17
Induction of neural stem cell-like cells (NSCLCs) from mouse astrocytes by Bmi1. (18439910)
2008
18
Frequency of pancreatic beta-cell autoimmunity markers in patients with autoimmune thyroid disease. (18416318)
2008
19
The evolving transcriptome of head and neck squamous cell carcinoma: a systematic review. (18791647)
2008
20
Four cardiac hormones eliminate up to two-thirds of human breast cancers in athymic mice. (18210743)
2007
21
Use of multidetector CT angiography and 3D postprocessing in a case of pulmonary sequestration. (17449384)
2007
22
Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia. (17317858)
2007
23
Proangiogenic role of neutrophil-like inflammatory heterophils during neovascularization induced by growth factors and human tumor cells. (16174763)
2006
24
Distinct expression and localization of serine protease HtrA1 in human endometrium and first-trimester placenta. (17072861)
2006
25
Reduction of angiocidin expression in human umbilical vein endothelial cells via siRNA silencing inhibits angiogenesis. (16904104)
2006
26
Anti-angiogenic effect of an insertional fusion protein of human basic fibroblast growth factor and ribonuclease-1. (15980015)
2005
27
Usefulness of an elevated B-type natriuretic peptide in predicting survival in patients with aortic stenosis treated without surgery. (16275196)
2005
28
Altered differentiation of neural stem cells in fragile X syndrome. (16314562)
2005
29
Simultaneous serous cystadenoma of the pancreas and mucinous cystadenoma of the appendix. (15007191)
2004
30
Sudden death due to dissecting aortic aneurysm in an adolescent without any underlying disease. (12421274)
2002
31
L- and M-cone-driven electroretinograms in Stargardt's macular dystrophy-fundus flavimaculatus. (11328755)
2001
32
The ratio of cytokine levels in genital herpes during various phases of infection. (11687847)
2001
33
Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis. (11741536)
2001
34
Cohort mortality study of North American industrial sand workers. II. Case-referent analysis of lung cancer and silicosis deaths. (11295143)
2001
35
Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2. (11328751)
2001
36
Long-term (29 years) results of reconstructive surgery in rheumatic mitral valve insufficiency. (11568022)
2001
37
Prolactin-regulated apoptosis of Nb2 lymphoma cells: pim-1, bcl-2, and bax expression. (9867250)
1998
38
Cloning, expression, and chromosomal assignment of the human mitochondrial intermediate peptidase gene (MIPEP). (9073519)
1997
39
Parathyroid hormone inhibits Na(+)-K(+)-ATPase through a cytochrome P-450 pathway. (8160800)
1994
40
Disturbance of visual information processing in temporal lobe epilepsy: in comparison with idiopathic generalized epilepsy. (8271589)
1993
41
Autocrine and paracrine effects of endothelium-derived relaxing factor on intracellular Ca2+ of endothelial cells and vascular smooth muscle cells. Identification by two-dimensional image analysis in coculture. (1400356)
1992
42
Ventricular standstill complicating left heart catheterization in the presence of uncomplicated right bundle branch block. (1306060)
1992
43
Caffeic acid causes metal-dependent damage to cellular and isolated DNA through H2O2 formation. (1394830)
1992
44
Evolution of EF-hand calcium-modulated proteins. II. Domains of several subfamilies have diverse evolutionary histories. (1602495)
1992
45
Effects of treatment with nasal continuous positive airway pressure on atrial natriuretic peptide and arginine vasopressin release during sleep in patients with obstructive sleep apnoea. (1851683)
1991
46
Shedding of CD9 antigen into cerebrospinal fluid by acute lymphoblastic leukemia cells. (2364164)
1990
47
Effect of fibrin-targeting on clot lysis with urokinase-type plasminogen activator. (2107593)
1990
48
Neuromodulative actions of cytokines. (2205054)
1990
49
50

Variations for Limbic Encephalitis

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Expression for genes affiliated with Limbic Encephalitis

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Search GEO for disease gene expression data for Limbic Encephalitis.

Pathways for genes affiliated with Limbic Encephalitis

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GO Terms for genes affiliated with Limbic Encephalitis

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Cellular components related to Limbic Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicle membraneGO:00306729.9AMPH, GAD2
2clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:00612029.6GAD1, GAD2

Biological processes related to Limbic Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular oxidant detoxificationGO:00988699.7GSR, TPO

Sources for Limbic Encephalitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet