MCID: LMB024
MIFTS: 48

Limbic Encephalitis malady

Rare diseases category

Summaries for Limbic Encephalitis

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NIH Rare Diseases:42 Limbic encephalitis is a condition marked by the inflammation of the limbic system and other parts of the brain. the cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. the symptoms typically develop over a few weeks or months, but they may evolve over a few days. delayed diagnosis is common, but improvements are being made to assist in early detection. early diagnosis may improve the outcome of limbic encephalitis. last updated: 6/8/2009

MalaCards based summary: Limbic Encephalitis is related to encephalitis and paraneoplastic syndromes. An important gene associated with Limbic Encephalitis is GAD1 (glutamate decarboxylase 1 (brain, 67kDa)), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Immune response MIF mediated glucocorticoid regulation. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and temporal lobe, and related mouse phenotypes are normal and endocrine/exocrine gland.

Wikipedia:64 Limbic encephalitis is a form of encephalitis, a disease characterised by inflammation of the brain.... more...

Aliases & Classifications for Limbic Encephalitis

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Sources:
42NIH Rare Diseases, 44Novoseek, 61UMLS
See all sources

Limbic Encephalitis, Aliases & Descriptions:

Name: Limbic Encephalitis 42 44 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Limbic Encephalitis

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Diseases related to Limbic Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis32.3GAD2, PNMA2, AMPH, LGI1
2paraneoplastic syndromes30.8AMPH, IL6
3stiff-person syndrome30.6GAD1, GAD2, AMPH
4thyroiditis30.6TG, TPO, GAD2
5multiple sclerosis30.6IFNG, GSR, GAD1, IL6
6temporal lobe epilepsy30.5GRIN2B, GAD2, GAD1, LGI1
7systemic lupus erythematosus30.5IFNG, TPO, IL6, ENO1
8alzheimer's disease29.9GRIN2B, GSR, GRIA1, IL6, GAD1
9epilepsy syndrome29.4GRIA1, GSR, GRIN2B, LGI1, GAD2, GAD1
10non-herpetic acute limbic encephalitis10.7
11teratoma10.7
12thymoma10.6
13neuronitis10.6
14lung cancer10.6
15relapsing polychondritis10.5
16status epilepticus10.5
17pernicious anemia10.5TG, TPO
18subacute thyroiditis10.5TPO, TG
19toxic diffuse goiter10.4TG, TPO
20endemic goiter10.4TG, TPO
21nontoxic goiter10.4TPO, TG
22plummer's disease10.4TPO, TG
23multinodular goiter10.4TG, TPO
24myxedema10.4TG, TPO
25thyrotropin deficiency, isolated10.4TPO, TG
26adenocarcinoma10.4
27testicular cancer10.4
28limbic encephalitis with dpp6 antibodies10.4
29autoimmune thyroiditis10.4TG, TPO
30thyrotoxicosis10.4TPO, TG
31autosomal dominant hyper ige syndrome10.4IL6, IFNG
32nodular goiter10.4TG, TPO
33pendred syndrome10.4TG, TPO
34premature ovarian failure10.4TPO, ENO1
35hypothyroidism10.4TG, TPO
36rasmussen encephalitis10.4GAD1, GSR
37diabetic ketoacidosis10.4GAD2, GAD1
38breast cancer10.4
39dementia10.4
40prostatitis10.4
41classic paraneoplastic limbic encephalitis10.4
42limbic encephalitis with lgi1 antibodies10.4
43limbic encephalitis with ncmags antibodies10.4
44posttransplant acute limbic encephalitis10.4
45limbic encephalitis with nmda receptor antibodies10.4
46turner syndrome10.3TPO, TG
47autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.3GAD1, GAD2
48follicular thyroid carcinoma10.3TPO, TG
49diabetic neuropathy10.3GAD2, GAD1
50papillary thyroid carcinoma10.3TG, TPO

Graphical network of the top 20 diseases related to Limbic Encephalitis:



Diseases related to limbic encephalitis

Symptoms for Limbic Encephalitis

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Drugs & Therapeutics for Limbic Encephalitis

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Drug clinical trials:

Search ClinicalTrials for Limbic Encephalitis

Search NIH Clinical Center for Limbic Encephalitis

Genetic Tests for Limbic Encephalitis

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Anatomical Context for Limbic Encephalitis

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MalaCards organs/tissues related to Limbic Encephalitis:

32
Brain, Lung, Temporal lobe, Bone marrow, Bone, Colon, Breast, Prostate, Eye, Spinal cord, Thyroid, Myeloid, Monocytes, B cells, Amygdala, Neutrophil

Animal Models for Limbic Encephalitis or affiliated genes

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MGI Mouse Phenotypes related to Limbic Encephalitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.8GAD2, GAD1, GRIA1, GSR, IFNG, BRSK2
2MP:00053798.3TPO, TG, AMPH, IFNG, IL6, GAD1
3MP:00053786.9PPP1R9B, TPO, TG, ADAM22, LGI1, IFNG
4MP:00107686.9ADAM22, BRSK2, AMPH, TPO, ELAVL3, LGI1
5MP:00053766.8TG, TPO, SH2D1A, PPP1R9B, ELAVL3, IFNG
6MP:00053866.2ELAVL3, ADAM22, BRSK2, AMPH, PPP1R9B, LGI1
7MP:00036316.0GAD2, PPP1R9B, TG, AMPH, BRSK2, ADAM22

Publications for Limbic Encephalitis

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Articles related to Limbic Encephalitis:

(show top 50)    (show all 377)
idTitleAuthorsYear
1
Limbic encephalitis due to GABAB and AMPA receptor antibodies: a case series. (25300449)
2014
2
Mature ovarian teratoma-associated limbic encephalitis. (25093683)
2014
3
Autoimmune limbic encephalitis and anesthesia. (24104946)
2013
4
Limbic encephalitis: a clinical-radiological comparison between herpetic and autoimmune etiologies. (23941332)
2013
5
Correlative imaging with (18)F-FDG PET/CT and MRI in paraneoplastic limbic encephalitis. (23531769)
2013
6
Voltage-gated potassium channel antibody paraneoplastic limbic encephalitis associated with acute myeloid leukemia. (23898271)
2013
7
Limbic Encephalitis Associated With Elevated Antithyroid Antibodies. (23520363)
2013
8
Autoimmune limbic encephalitis presenting as relapsing psychosis. (23997078)
2013
9
Limbic encephalitis in a child: an atypical presentation. (24095576)
2013
10
The diagnosis and treatment of limbic encephalitis. (22713136)
2012
11
Surgical control of limbic encephalitis associated with LGI1 antibodies. (22940785)
2012
12
Two different 18F-FDG brain PET metabolic patterns in autoimmune limbic encephalitis. (22889795)
2012
13
Cord-blood hematopoietic stem cell transplantA confers an increased risk for human herpesvirus-6-associated acute limbic encephalitis: aA cohort analysis. (22564265)
2012
14
Proposition: limbic encephalitis may represent limbic status epilepticus. A review of clinical and EEG characteristics. (22459869)
2012
15
A boy with non-herpes simplex acute limbic encephalitis and antiglutamate receptor antibodies. (22084613)
2011
16
Continuous muscle activity, Morvan's syndrome and limbic encephalitis: ionic or non ionic disorders? (21842591)
2011
17
Autoimmune Limbic Encephalitis With GAD Antibodies. (23983853)
2011
18
Recognition of faciobrachial dystonic seizures allowing early intervention with and prevention of development of full-blown limbic encephalitis. (22319790)
2011
19
Steroid-responsive recurrent limbic encephalitis associated with small cell lung cancer and neuropil antibodies. (21748934)
2011
20
Paraneoplastic syndrome of inappropriate antidiuretic hormone mimicking limbic encephalitis. (22159058)
2011
21
An effective immunotherapy regimen for VGKC antibody-positive limbic encephalitis. (20660916)
2010
22
Non-paraneoplastic limbic encephalitis associated with NMDAR and VGKC antibodies. (20667865)
2010
23
Limbic encephalitis associated with systemic lupus erythematosus. (19850655)
2009
24
Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis. (19716567)
2009
25
Voltage-gated potassium channel-associated limbic encephalitis in the West of Scotland: case reports and literature review. (20034278)
2009
26
An autopsy case with non-herpetic acute limbic encephalitis (NHALE). (18282167)
2008
27
Paraneoplastic limbic encephalitis as a cause of new onset of seizures in a patient with non-small cell lung carcinoma: a case report. (18700972)
2008
28
Acute limbic encephalitis: diagnostic and management implications. (18197513)
2008
29
Limbic encephalitis as presentation of a SAP deficiency. (17620557)
2007
30
Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. (17620548)
2007
31
Complex partial status epilepticus in paraneoplastic limbic encephalitis. (17844948)
2007
32
Limbic encephalitis--an uncommon presentation of systemic malignancy. (18173029)
2007
33
Limbic encephalitis: extension of the diagnostic armamentarium. (17018560)
2007
34
Limbic encephalitis: another example of molecular mimicry? (17389799)
2007
35
Anti-Hu-associated paraneoplastic limbic encephalitis presenting as rapidly progressive non-convulsive status epilepticus. (16631204)
2006
36
Reversible paraneoplastic limbic encephalitis caused by a benign ovarian teratoma: report of a case and review of literatures. (16944314)
2006
37
Electroconvulsive therapy in a pediatric patient with malignant catatonia and paraneoplastic limbic encephalitis. (17143159)
2006
38
Paraneoplastic limbic encephalitis. (15708228)
2005
39
Neurosyphilis and paraneoplastic limbic encephalitis: important differential diagnoses. (15789128)
2005
40
Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. (15888538)
2005
41
A pre-senile case of limbic encephalitis and cerebellar degeneration, with subacute onset of progressive dementia. (15673963)
2004
42
Non-herpetic acute limbic encephalitis: a new subgroup of limbic encephalitis? (15168784)
2004
43
Resolution of limbic encephalitis with detection and treatment of lung cancer: clinical-radiological correlation. (12499067)
2003
44
Asessment of paraneoplastic limbic encephalitis in testicular cancer. (12846502)
2003
45
Paraneoplastic limbic encephalitis masquerading as chronic behavioural disturbance in an adolescent girl. (12801123)
2003
46
Hypermetabolism of the medial temporal lobe in limbic encephalitis on (18)FDG-PET scan: a case report. (11306867)
2001
47
Varicella-zoster virus limbic encephalitis in an immunocompromised patient. (11728054)
2001
48
Paraneoplastic limbic encephalitis should not be overlooked as a possible cause of delirium in cancer patients. (11025799)
2000
49
Limbic encephalitis. A rare presentation of the small-cell lung carcinoma. (2553530)
1989
50
Small-cell lung cancer and limbic encephalitis. (6283978)
1982

Variations for Limbic Encephalitis

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Expression for genes affiliated with Limbic Encephalitis

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Expression patterns in normal tissues for genes affiliated with Limbic Encephalitis

Search GEO for disease gene expression data for Limbic Encephalitis.

Pathways for genes affiliated with Limbic Encephalitis

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Pathways related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TG, TPO
210.0IL6, IFNG
310.0IFNG, IL6
410.0GAD2, GAD1
5
Show member pathways
catecholamine biosynthesis37
10.0GAD2, GAD1
6
Show member pathways
10.0GAD2, GAD1
7
Show member pathways
10.0GAD1, GAD2
8
Show member pathways
10.0GAD1, GAD2
9
Show member pathways
Type III interferon signaling37
9.8IL6, IFNG, TPO
109.8ENO1, IL6, IFNG
11
Show member pathways
9.7GSR, TG, TPO
12
Show member pathways
thioredoxin pathway37
9.7GSR, IL6, IFNG
139.7ENO1, GAD2, BRSK2
14
Show member pathways
9.3GRIA1, GRIN2B, GAD1, GAD2
15
Show member pathways
9.3GRIA1, GRIN2B, GAD1, GAD2
16
Show member pathways
9.3GRIA1, GRIN2B, GAD1, GAD2
17
Show member pathways
9.1GAD2, GAD1, IL6, IFNG, TG, TPO
18
Show member pathways
8.6PPP1R9B, TPO, IFNG, IL6, GRIN2B
198.2PPP1R9B, BRSK2, GRIA1, GRIN2B, GAD1, GAD2

Compounds for genes affiliated with Limbic Encephalitis

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Compounds related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1iodotyrosine44 2511.5TG, TPO
2diiodotyrosine4410.4TG, TPO
3perchlorate4410.4TPO, TG
4Cysteic acid2510.4GAD2, GAD1
518f fluorodeoxyglucose4410.3TG, GAD1
6cysteine sulfinic acid4410.3GAD2, GAD1
7bucillamine4410.3IFNG, IL6
8hypotaurine60 44 2512.3GAD1, GAD2
9gamma globulin4410.3TG, IFNG
10sodium iodide4410.3TPO, TG
11guaiacol44 2511.2TPO, GSR
12vesnarinone4410.2IFNG, IL6
13atpo29 4411.2TPO, GRIA1
14taurine chloramine4410.2IFNG, IL6
153-amino-1,2,4-triazole4410.2GSR, TG
16gliadin4410.2GAD2, TG, TPO
17propylthiouracil44 3 1212.2TPO, TG
18125i4410.2TPO, TG, GAD2
19chromium4410.2GSR, TG, TPO
20ivig4410.2TG, IFNG, IL6
21methimazole44 3 1212.1GSR, TG, TPO
22c-peptide4410.1TPO, GAD1, GAD2
233-Sulfinoalanine25 1211.1GAD2, GAD1, GSR
24selenium44 2511.1TPO, TG, GSR
25d penicillamine4410.1IFNG, GSR
26melphalan44 50 1212.0GSR, IL6, IFNG
27prednisolone44 29 1212.0GAD1, IL6, IFNG, TG
28hydrocortisone44 3 60 1213.0TPO, TG, IFNG, IL6
29gold449.9GAD1, TG, TPO
30ebselen449.8GSR, IFNG
31alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid449.8GRIA1, GSR
32aspartate449.7TPO, TG, GSR, GAD1, ENO1
33cyclosporin a44 29 6011.7TG, IFNG, IL6, GAD1, GAD2
34gaba449.7GAD2, GAD1, GRIA1, GSR
35genistein44 29 60 3 25 1214.7TPO, TG, IFNG, IL6, GSR
36creatinine449.5TPO, TG, IL6, GSR, GAD1, ENO1
37glutamine449.5TG, GRIA1, GAD1, ENO1
38acetylcholine44 50 29 25 1213.5TPO, TG, AMPH, GAD1, GAD2
39l-glutamic acid29 25 1211.4GSR, GRIA1, GRIN2B, GAD1, GAD2
40kainate44 2910.4GSR, GRIA1, GRIN2B, GAD1, GAD2
41alanine449.4TG, IL6, GSR, GAD1, GAD2
42nmda44 2910.4GSR, GRIA1, GRIN2B, GAD1, GAD2
43cysteine449.2TPO, TG, IFNG, GSR, GAD1, GAD2
44arginine449.2TPO, TG, IFNG, GSR, GRIA1, GAD1
45lactate449.2TG, IL6, GSR, ENO1
46nitric oxide44 25 1211.0TPO, IFNG, IL6, GRIA1, GRIN2B, GAD1
47dopamine44 29 25 1211.8PPP1R9B, GRIA1, GRIN2B, GAD1, GAD2
48tyrosine448.7SH2D1A, TPO, TG, IL6, GRIA1, GRIN2B
49calcium44 50 25 1211.4SH2D1A, TPO, AMPH, GRIA1, GRIN2B, GAD1
50glutamate447.4ENO1, PPP1R9B, TPO, TG, AMPH, GSR

GO Terms for genes affiliated with Limbic Encephalitis

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Cellular components related to Limbic Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.0GAD2, GAD1
2synaptic vesicleGO:0080219.1AMPH, GRIA1, GRIN2B
3extracellular spaceGO:0056158.8TPO, TG, LGI1, IFNG, IL6, ENO1
4cell junctionGO:0300548.7GAD2, GRIN2B, GRIA1, LGI1, AMPH

Biological processes related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylation to succinateGO:00654010.2GAD2, GAD1
2neutrophil apoptotic processGO:00178110.2IFNG, IL6
3hormone biosynthetic processGO:04244610.2TG, TPO
4thyroid hormone generationGO:00659010.1TG, TPO
5neurotransmitter biosynthetic processGO:04213610.0GAD1, GAD2
6humoral immune responseGO:0069599.9IL6, IFNG, SH2D1A
7defense response to protozoanGO:0428329.9IL6, IFNG
8ionotropic glutamate receptor signaling pathwayGO:0352359.8GRIN2B, GRIA1
9response to drugGO:0424939.7IFNG, IL6, GAD1, GAD2
10nucleobase-containing small molecule interconversionGO:0159499.3GSR, AK5
11synaptic transmissionGO:0072689.0GAD2, GAD1, GRIN2B, GRIA1, AMPH

Molecular functions related to Limbic Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylase activityGO:00435110.0GAD2, GAD1
2extracellular-glutamate-gated ion channel activityGO:0052349.8GRIN2B, GRIA1
3glutamate bindingGO:0165959.7GAD2, GAD1
4protein bindingGO:0055155.8PPP1R9B, PNMA2, SH2D1A, AMPH, ADAM22, LGI1

Products for genes affiliated with Limbic Encephalitis

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Sources for Limbic Encephalitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet