MCID: LMB024
MIFTS: 47

Limbic Encephalitis malady

Neuronal category

Summaries for Limbic Encephalitis

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
See all sources

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NIH Rare Diseases:43 Limbic encephalitis is a condition marked by the inflammation of the limbic system and other parts of the brain. the cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. the symptoms typically develop over a few weeks or months, but they may evolve over a few days. delayed diagnosis is common, but improvements are being made to assist in early detection. early diagnosis may improve the outcome of limbic encephalitis. last updated: 6/8/2009

MalaCards: Limbic Encephalitis is related to status epilepticus and adenocarcinoma. An important gene associated with Limbic Encephalitis is GAD1 (glutamate decarboxylase 1 (brain, 67kDa)), and among its related pathways are Taurine and hypotaurine metabolism and GABA synthesis. The compounds melphalan and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and cortex, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Wikipedia:64 Limbic encephalitis is a form of encephalitis, a disease characterised by inflammation of the brain.... more...

Aliases & Classifications for Limbic Encephalitis

Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 61UMLS, 36MESH via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

limbic encephalitis 43 45 49 61


External Ids:

MESH via Orphanet36 D020363
SNOMED-CT via Orphanet58 230192003
UMLS via Orphanet62 C0338430

Related Diseases for Limbic Encephalitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Limbic Encephalitis family:

limbic encephalitis with lgi1 antibodies limbic encephalitis with ncmags antibodies
limbic encephalitis with caspr2 antibodies limbic encephalitis with nmda receptor antibodies
limbic encephalitis with dpp6 antibodies

Diseases related to Limbic Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1status epilepticus30.7GAD1
2adenocarcinoma30.6ENO1
3temporal lobe epilepsy30.5GRIN2B, GAD1, GAD2, LGI1
4common variable immune deficiency30.1SH2D1A
5stiff-person syndrome30.1GAD1, AMPH, GAD2
6systemic lupus erythematosus30.1TPO, IFNG, ENO1, IL6
7autoimmune encephalitis10.8
8thymoma10.6
9teratoma10.6
10relapsing polychondritis10.5
11small cell carcinoma10.5
12testicular cancer10.4
13classic paraneoplastic limbic encephalitis10.4
14sleep disorder10.3
15limbic encephalitis with lgi1 antibodies10.3
16limbic encephalitis with ncmags antibodies10.3
17posttransplant acute limbic encephalitis10.3
18limbic encephalitis with nmda receptor antibodies10.3
19limbic encephalitis with dpp6 antibodies10.3
20viral encephalitis10.2
21anterograde amnesia10.2
22n syndrome10.2
23cerebellar degeneration10.2
24herpes simplex encephalitis10.2
25neurosyphilis10.2
26ataxia10.2
27myoclonus10.2
28other forms of non-paraneoplastic limbic encephalitis10.2
29non-herpetic acute limbic encephalitis10.2
30limbic encephalitis with caspr2 antibodies10.2
31subacute sclerosing panencephalitis10.1
32narcolepsy10.1
33prostate small cell carcinoma10.1
34syphilitic encephalitis10.1
35lambert-eaton myasthenic syndrome10.1
36primary biliary cirrhosis10.1
37acute myeloid leukemia10.1
38temporal lobe neoplasm10.1
39acute disseminated encephalomyelitis10.1
40gliomatosis cerebri10.1
41bronchogenic carcinoma10.1
42spinal cord astrocytoma10.1
43acute leukemia10.1
44aplastic anemia10.1
45astrocytoma10.1
46brain disease10.1
47squamous cell carcinoma10.1
48t-cell leukemia10.1
49hereditary sensory and autonomic neuropathy type ii10.1
50lambert syndrome10.1

Graphical network of the top 20 diseases related to Limbic Encephalitis:



Diseases related to limbic encephalitis

Clinical Features for Limbic Encephalitis

Drugs & Therapeutics for Limbic Encephalitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Limbic Encephalitis

Drug clinical trials:

Search ClinicalTrials for Limbic Encephalitis

Search NIH Clinical Center for Limbic Encephalitis

Search CenterWatch for Limbic Encephalitis

Genetic Tests for Limbic Encephalitis

Anatomical Context for Limbic Encephalitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Limbic Encephalitis:

33
Bone marrow, Brain, Cortex, Spinal cord, Colon, Lung, Thyroid, Breast, Prostate, Myeloid, Monocytes, B cells, Prefrontal cortex, Cingulate cortex, Temporal lobe, Amygdala, Trigeminal ganglion

Animal Models for Limbic Encephalitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Limbic Encephalitis

Sources:
51PubMed
See all sources

Articles related to Limbic Encephalitis:

(show top 50)    (show all 364)
idTitleAuthorsYear
1
Limbic encephalitis associated with anti-voltage-gated potassium channel complex antibodies mimicking creutzfeldt-jakob disease. (24247910)
2014
2
Limbic encephalitis: a clinical-radiological comparison between herpetic and autoimmune etiologies. (23941332)
2013
3
Voltage-gated potassium channel antibody paraneoplastic limbic encephalitis associated with acute myeloid leukemia. (23898271)
2013
4
Severe hyponatremia caused by syndrome of inappropriate secretion of antidiuretic hormone developed as initial manifestation of human herpesvirus-6-associated acute limbic encephalitis after unrelated bone marrow transplantation. (23173742)
2013
5
Paraneoplastic limbic encephalitis resembling acute herpetic encephalitis. (24377054)
2013
6
Paraneoplastic CRMP-5 basal ganglionitis and limbic encephalitis in an elderly Indian lady. (24262464)
2013
7
A case of limbic encephalitis with positive antibody to the GABAB receptor. (24034128)
2013
8
Cerebellar symptoms in a case of acute limbic encephalitis associated with autoantibodies to glutamate receptors I'2 and E92. (22770725)
2013
9
Predictors of outcomes in acyclovir-treated limbic encephalitis. (23068447)
2013
10
Lysis of catatonic withdrawal by propofol in a bone-marrow transplant recipient with adenovirus limbic encephalitis. (22705183)
2013
11
The diagnosis and treatment of limbic encephalitis. (22713136)
2012
12
Paraneoplastic limbic encephalitis associated with ovarian teratoma. (22372238)
2012
13
A case of paraneoplastic limbic encephalitis associated with small cell lung cancer. (23236319)
2012
14
Lower extremity predominant stiff-person syndrome and limbic encephalitis with amphiphysin antibodies in breast cancer. (23172386)
2012
15
Opsoclonus-myoclonus and anti-Hu positive limbic encephalitis in a patient with neuroblastoma. (21480475)
2012
16
Anti-Hu-associated paraneoplastic limbic encephalitis in Hodgkin lymphoma. (22136379)
2012
17
Autoimmune Limbic Encephalitis With GAD Antibodies. (23983853)
2011
18
Unusual association of seronegative, nonparaneoplastic limbic encephalitis and relapsing polychondritis in a patient with history of thymectomy for myasthenia: a case study. (20706846)
2011
19
Acute disseminated encephalomyelitis with medial temporal lesions mimicking acute limbic encephalitis. (20934802)
2011
20
GABA(B) receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders. (21357831)
2011
21
Limbic encephalitis in children and adolescents. (20959359)
2011
22
Seronegative limbic encephalitis: case report, literature review and proposed treatment algorithm. (22100946)
2011
23
Reversible paraneoplastic limbic encephalitis associated with antibodies to the AMPA receptor. (20083804)
2010
24
Improvement of non-paraneoplastic voltage-gated potassium channel antibody-associated limbic encephalitis without immunosuppressive therapy. (20163992)
2010
25
A case of gliomatosis cerebri mimicking limbic encephalitis: malignant transformation to glioblastoma. (20606365)
2010
26
Treatment of anti-glutamic acid decarboxylase antibody-associated limbic encephalitis with mycophenolate mofetil. (20130897)
2010
27
Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis. (19716567)
2009
28
Voltage-gated potassium channel-associated limbic encephalitis in the West of Scotland: case reports and literature review. (20034278)
2009
29
Paraneoplastic limbic encephalitis cured with resection of an adnexal mass. (19793490)
2009
30
Limbic encephalitis presenting with anxiety and depression: a comprehensive neuropsychological formulation. (18609416)
2009
31
Reversible limbic encephalitis with antibodies against the membranes of neurones of the hippocampus. (21686771)
2009
32
Autoimmune limbic encephalitis. (19566502)
2009
33
Temporal lobectomy for refractory status epilepticus in a case of limbic encephalitis. (18826364)
2008
34
Epitope of autoantibodies to N-methyl-D-aspartate receptor heteromers in paraneoplastic limbic encephalitis. (18350587)
2008
35
Limbic encephalitis - a review. (18411052)
2008
36
Non-paraneoplastic limbic encephalitis associated with anti-glutamic acid decarboxylase antibodies. (18586329)
2008
37
Limbic encephalitis: an expanding concept. (18268242)
2008
38
Reversible limbic encephalitis with antibodies against the membranes of neurones of the hippocampus. (17308294)
2007
39
A chronic progressive case of enteroviral limbic encephalitis associated with autoantibody to glutamate receptor epsilon2. (17389802)
2007
40
Primary renal lymphoma presenting with paraneoplastic limbic encephalitis. (17704429)
2007
41
Reversible paraneoplastic limbic encephalitis caused by a benign ovarian teratoma: report of a case and review of literatures. (16944314)
2006
42
Electroconvulsive therapy in a pediatric patient with malignant catatonia and paraneoplastic limbic encephalitis. (17143159)
2006
43
Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations. (16613892)
2006
44
Resolution of limbic encephalitis with detection and treatment of lung cancer: clinical-radiological correlation. (12499067)
2003
45
Anti-amphiphysin associated limbic encephalitis: a paraneoplastic presentation of small-cell lung carcinoma. (12242559)
2002
46
Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. (10869059)
2000
47
Paraneoplastic limbic encephalitis associated with small cell carcinoma of the prostate. (10463484)
1999
48
Limbic encephalitis: a case report. (8194513)
1994
49
MR imaging of paraneoplastic limbic encephalitis. (2153718)
1990
50
Limbic encephalitis. (5346936)
1969

Genetic Variations for Limbic Encephalitis

Expression for genes affiliated with Limbic Encephalitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Limbic Encephalitis

Search GEO for disease gene expression data for Limbic Encephalitis.

Pathways for genes affiliated with Limbic Encephalitis

Sources:
30KEGG, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 4Cell Signaling Technology
See all sources

Pathways related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0GAD1, GAD2
210.0GAD1, GAD2
310.0GAD1, GAD2
410.0GAD2, GAD1
59.8IFNG, ENO1, IL6
6
Hide members
9.7GAD2, GAD1, TPO
7
Hide members
9.7TPO, TG, GSR
89.6IL6, IFNG, GSR
9
Hide members
9.5GAD2, GAD1, IFNG, IL6
10
Hide members
9.2GAD2, GRIA1, GRIN2B, GAD1
119.2GRIA1, GRIN2B, GAD1, GAD2
12
Hide members
8.5IFNG, GRIN2B, IL6, TPO, PPP1R9B
138.0PPP1R9B, GAD2, BRSK2, GRIN2B, GRIA1, GAD1

Compounds for genes affiliated with Limbic Encephalitis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB, 50PharmGKB
See all sources

Compounds related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1melphalan45 1111.4GSR
2iodotyrosine45 2411.4TG, TPO
3diiodotyrosine4510.4TG, TPO
4perchlorate4510.3TG, TPO
518f fluorodeoxyglucose4510.3TG, GAD1
6bucillamine4510.2IL6, IFNG
7cysteine sulfinic acid4510.2GAD2, GAD1
8hypotaurine60 45 2412.2GAD2, GAD1
9gamma globulin4510.2TG, IFNG
10aspartate4510.2GAD1, TPO, TG
11gliadin4510.1TG, GAD2, TPO
12guaiacol45 2411.1TPO, GSR
13atpo45 2911.1GRIA1, TPO
14sodium iodide4510.1TG, TPO
15chromium4510.1TG, GSR, TPO
16125i4510.1TG, GAD2, TPO
17ivig4510.1IFNG, IL6, TG
18methimazole45 2 1112.1GSR, TPO, TG
193-amino-1,2,4-triazole4510.0GSR, TG
20c-peptide4510.0GAD2, TPO, GAD1
213-Sulfinoalanine11 2411.0GAD2, GSR, GAD1
22selenium45 2411.0TG, GSR, TPO
23taurine chloramine4510.0IFNG, IL6
24prednisolone45 29 1111.9GAD1, IFNG, IL6, TG
25hydrocortisone45 2 60 1112.9IL6, IFNG, TPO, TG
26d penicillamine459.9IFNG, GSR
27vesnarinone459.9IL6, IFNG
28propylthiouracil45 2 1111.7TPO, TG
29acetylcholine45 50 29 11 2413.6TPO, AMPH, GAD2, GAD1
30cyclosporin a45 29 6011.6GAD1, IL6, GAD2, TG, IFNG
31genistein45 29 60 2 11 2414.6TG, TPO, IL6, GSR, IFNG
32gaba459.6GSR, GRIA1, GAD1, GAD2
33creatinine459.4IL6, GAD1, TPO, ENO1, GSR, TG
34l-glutamic acid29 11 2411.3GSR, GRIA1, GRIN2B, GAD1, GAD2
35kainate45 2910.3GAD2, GAD1, GRIN2B, GRIA1, GSR
36nmda45 2910.2GAD2, GAD1, GRIA1, GSR, GRIN2B
37cysteine459.1GAD2, TG, IFNG, GAD1, TPO, GSR
38arginine459.1GSR, TPO, ENO1, GRIA1, GAD1, IFNG
39nitric oxide45 11 2410.9IFNG, GAD2, GRIA1, GAD1, GRIN2B, TPO
40dopamine45 29 11 2411.7GRIN2B, PPP1R9B, GRIA1, GAD2, GAD1
41tyrosine458.6GAD2, GAD1, TG, TPO, IL6, GRIA1
42calcium45 50 11 2411.1GRIN2B, SH2D1A, ENO1, TPO, GAD2, AMPH
43glutamate457.3GAD2, ENO1, AMPH, TG, GSR, TPO

GO Terms for genes affiliated with Limbic Encephalitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Limbic Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.0GAD1, GAD2
2synaptic vesicleGO:0080218.9GRIA1, AMPH, GRIN2B
3cell junctionGO:0300548.5GRIN2B, AMPH, GAD2, LGI1, GRIA1

Biological processes related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1neutrophil apoptotic processGO:00178110.2IL6, IFNG
2glutamate decarboxylation to succinateGO:00654010.2GAD1, GAD2
3hormone biosynthetic processGO:04244610.0TPO, TG
4defense response to protozoanGO:04283210.0IL6, IFNG
5thyroid hormone generationGO:0065909.9TG, TPO
6humoral immune responseGO:0069599.9IFNG, SH2D1A, IL6
7neurotransmitter biosynthetic processGO:0421369.7GAD2, GAD1
8response to drugGO:0424939.5IFNG, GAD2, GAD1, IL6
9synaptic transmissionGO:0072688.8GAD2, AMPH, GAD1, GRIN2B, GRIA1

Molecular functions related to Limbic Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate bindingGO:01659510.0GAD1, GAD2
2glutamate decarboxylase activityGO:0043519.7GAD1, GAD2

Products for genes affiliated with Limbic Encephalitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Limbic Encephalitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet