MCID: LMB024
MIFTS: 53

Limbic Encephalitis malady

Rare diseases, Neuronal diseases categories
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Summaries for Limbic Encephalitis

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Limbic encephalitis is a condition marked by the inflammation of the limbic system and other parts of the brain. the cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. the symptoms typically develop over a few weeks or months, but they may evolve over a few days. delayed diagnosis is common, but improvements are being made to assist in early detection. early diagnosis may improve the outcome of limbic encephalitis. last updated: 6/8/2009

MalaCards: Limbic Encephalitis is related to encephalitis and temporal lobe epilepsy. An important gene associated with Limbic Encephalitis is GAD1 (glutamate decarboxylase 1 (brain, 67kDa)), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Cytokines and Inflammatory Response. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and temporal lobe, and related mouse phenotypes are normal and endocrine/exocrine gland.

Wikipedia:65 Limbic encephalitis is a form of encephalitis, a disease characterised by inflammation of the brain.... more...

Aliases & Classifications for Limbic Encephalitis

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43NIH Rare Diseases, 45Novoseek, 49Orphanet, 62UMLS, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

limbic encephalitis 43 45 49 62


External Ids:

MESH via Orphanet36 D020363
SNOMED-CT via Orphanet59 230192003
UMLS via Orphanet63 C0338430

Related Diseases for Limbic Encephalitis

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17GeneCards, 18GeneDecks
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Diseases related to Limbic Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis32.1GAD2, PNMA2, AMPH, LGI1
2temporal lobe epilepsy30.6GRIN2B, GAD2, GAD1, LGI1
3multiple sclerosis30.4IFNG, GSR, GAD1, IL6
4paraneoplastic syndromes30.3AMPH, IL6
5stiff-person syndrome30.3GAD1, GAD2, AMPH
6thyroiditis30.3TG, TPO, GAD2
7encephalomyelitis30.3GAD2, GAD1, IFNG
8alzheimer's disease30.2GRIN2B, GSR, GRIA1, IL6, GAD1
9systemic lupus erythematosus30.2IFNG, TPO, IL6, ENO1
10epilepsy syndrome30.0GRIA1, GSR, GRIN2B, LGI1, GAD2, GAD1
11non-herpetic acute limbic encephalitis10.7
12thymoma10.6
13teratoma10.6
14neuronitis10.6
15lung cancer10.6
16status epilepticus10.5
17relapsing polychondritis10.5
18adenocarcinoma10.4
19testicular cancer10.4
20limbic encephalitis with dpp6 antibodies10.4
21breast cancer10.3
22dementia10.3
23prostatitis10.3
24classic paraneoplastic limbic encephalitis10.3
25limbic encephalitis with lgi1 antibodies10.3
26limbic encephalitis with ncmags antibodies10.3
27posttransplant acute limbic encephalitis10.3
28limbic encephalitis with nmda receptor antibodies10.3
29viral encephalitis10.3
30anterograde amnesia10.3
31creutzfeldt-jakob disease10.3
32cerebellar ataxia10.3
33herpes simplex10.3
34leukemia10.3
35myasthenia gravis10.3
36prostate cancer10.3
37cerebellar degeneration10.3
38neurosyphilis10.3
39ataxia10.3
40myoclonus10.3
41limbic encephalitis with caspr2 antibodies10.3
42narcolepsy10.1
43subacute sclerosing panencephalitis10.1
44acute disseminated encephalomyelitis10.1
45gliomatosis cerebri10.1
46lambert-eaton myasthenic syndrome10.1
47cerebritis10.1
48primary biliary cirrhosis10.1
49acute myeloid leukemia10.1
50small cell carcinoma10.1

Graphical network of the top 20 diseases related to Limbic Encephalitis:



Diseases related to limbic encephalitis

Symptoms for Limbic Encephalitis

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Drugs & Therapeutics for Limbic Encephalitis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Limbic Encephalitis

Search NIH Clinical Center for Limbic Encephalitis

Genetic Tests for Limbic Encephalitis

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Anatomical Context for Limbic Encephalitis

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33MalaCards
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MalaCards organs/tissues related to Limbic Encephalitis:

33
Brain, Lung, Temporal lobe, Prostate, Breast, Bone marrow, Colon, Bone, Eye, Spinal cord, Myeloid, Monocytes, B cells, Thyroid

Animal Models for Limbic Encephalitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Limbic Encephalitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.8GAD2, GAD1, GRIA1, GSR, IFNG, BRSK2
2MP:00053798.3TPO, TG, AMPH, IFNG, IL6, GAD1
3MP:00053786.9PPP1R9B, TPO, TG, ADAM22, LGI1, IFNG
4MP:00107686.9ADAM22, BRSK2, AMPH, TPO, ELAVL3, LGI1
5MP:00053766.8TG, TPO, SH2D1A, PPP1R9B, ELAVL3, IFNG
6MP:00053866.2ELAVL3, ADAM22, BRSK2, AMPH, PPP1R9B, LGI1
7MP:00036316.0GAD2, PPP1R9B, TG, AMPH, BRSK2, ADAM22

Publications for Limbic Encephalitis

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52PubMed
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Articles related to Limbic Encephalitis:

(show top 50)    (show all 354)
idTitleAuthorsYear
1
Autoimmune limbic encephalitis and anesthesia. (24104946)
2013
2
Limbic encephalitis: a clinical-radiological comparison between herpetic and autoimmune etiologies. (23941332)
2013
3
Correlative imaging with (18)F-FDG PET/CT and MRI in paraneoplastic limbic encephalitis. (23531769)
2013
4
Voltage-gated potassium channel antibody paraneoplastic limbic encephalitis associated with acute myeloid leukemia. (23898271)
2013
5
Limbic Encephalitis Associated With Elevated Antithyroid Antibodies. (23520363)
2013
6
Autoimmune limbic encephalitis presenting as relapsing psychosis. (23997078)
2013
7
Limbic encephalitis in a child: an atypical presentation. (24095576)
2013
8
A discrepancy between clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis. (23888211)
2013
9
The diagnosis and treatment of limbic encephalitis. (22713136)
2012
10
Surgical control of limbic encephalitis associated with LGI1 antibodies. (22940785)
2012
11
Two different 18F-FDG brain PET metabolic patterns in autoimmune limbic encephalitis. (22889795)
2012
12
Cord-blood hematopoietic stem cell transplantA confers an increased risk for human herpesvirus-6-associated acute limbic encephalitis: aA cohort analysis. (22564265)
2012
13
Proposition: limbic encephalitis may represent limbic status epilepticus. A review of clinical and EEG characteristics. (22459869)
2012
14
Limbic Encephalitis due to Pancreatic Cancer. (23147548)
2012
15
A boy with non-herpes simplex acute limbic encephalitis and antiglutamate receptor antibodies. (22084613)
2011
16
Continuous muscle activity, Morvan's syndrome and limbic encephalitis: ionic or non ionic disorders? (21842591)
2011
17
Autoimmune Limbic Encephalitis With GAD Antibodies. (23983853)
2011
18
Recognition of faciobrachial dystonic seizures allowing early intervention with and prevention of development of full-blown limbic encephalitis. (22319790)
2011
19
Steroid-responsive recurrent limbic encephalitis associated with small cell lung cancer and neuropil antibodies. (21748934)
2011
20
Paraneoplastic syndrome of inappropriate antidiuretic hormone mimicking limbic encephalitis. (22159058)
2011
21
An effective immunotherapy regimen for VGKC antibody-positive limbic encephalitis. (20660916)
2010
22
Non-paraneoplastic limbic encephalitis associated with NMDAR and VGKC antibodies. (20667865)
2010
23
Limbic encephalitis associated with systemic lupus erythematosus. (19850655)
2009
24
Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis. (19716567)
2009
25
Voltage-gated potassium channel-associated limbic encephalitis in the West of Scotland: case reports and literature review. (20034278)
2009
26
An autopsy case with non-herpetic acute limbic encephalitis (NHALE). (18282167)
2008
27
Paraneoplastic limbic encephalitis as a cause of new onset of seizures in a patient with non-small cell lung carcinoma: a case report. (18700972)
2008
28
Acute limbic encephalitis: diagnostic and management implications. (18197513)
2008
29
Limbic encephalitis as presentation of a SAP deficiency. (17620557)
2007
30
Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. (17620548)
2007
31
Complex partial status epilepticus in paraneoplastic limbic encephalitis. (17844948)
2007
32
Limbic encephalitis--an uncommon presentation of systemic malignancy. (18173029)
2007
33
Limbic encephalitis: extension of the diagnostic armamentarium. (17018560)
2007
34
Limbic encephalitis: another example of molecular mimicry? (17389799)
2007
35
Anti-Hu-associated paraneoplastic limbic encephalitis presenting as rapidly progressive non-convulsive status epilepticus. (16631204)
2006
36
Reversible paraneoplastic limbic encephalitis caused by a benign ovarian teratoma: report of a case and review of literatures. (16944314)
2006
37
Electroconvulsive therapy in a pediatric patient with malignant catatonia and paraneoplastic limbic encephalitis. (17143159)
2006
38
Paraneoplastic limbic encephalitis. (15708228)
2005
39
Neurosyphilis and paraneoplastic limbic encephalitis: important differential diagnoses. (15789128)
2005
40
Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. (15888538)
2005
41
A pre-senile case of limbic encephalitis and cerebellar degeneration, with subacute onset of progressive dementia. (15673963)
2004
42
Non-herpetic acute limbic encephalitis: a new subgroup of limbic encephalitis? (15168784)
2004
43
Resolution of limbic encephalitis with detection and treatment of lung cancer: clinical-radiological correlation. (12499067)
2003
44
Asessment of paraneoplastic limbic encephalitis in testicular cancer. (12846502)
2003
45
Paraneoplastic limbic encephalitis masquerading as chronic behavioural disturbance in an adolescent girl. (12801123)
2003
46
Hypermetabolism of the medial temporal lobe in limbic encephalitis on (18)FDG-PET scan: a case report. (11306867)
2001
47
Varicella-zoster virus limbic encephalitis in an immunocompromised patient. (11728054)
2001
48
Paraneoplastic limbic encephalitis should not be overlooked as a possible cause of delirium in cancer patients. (11025799)
2000
49
Limbic encephalitis. A rare presentation of the small-cell lung carcinoma. (2553530)
1989
50
Small-cell lung cancer and limbic encephalitis. (6283978)
1982

Variations for Limbic Encephalitis

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Expression for genes affiliated with Limbic Encephalitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Limbic Encephalitis

Search GEO for disease gene expression data for Limbic Encephalitis.

Pathways for genes affiliated with Limbic Encephalitis

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 30KEGG, 5Cell Signaling Technology, 12EMD Millipore, 54R&D Systems, 53QIAGEN
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Pathways related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TPO, TG
210.0IFNG, IL6
310.0IFNG, IL6
4
Show member pathways
catecholamine biosynthesis38
10.0GAD1, GAD2
510.0GAD1, GAD2
6
Show member pathways
10.0GAD1, GAD2
7
Show member pathways
10.0GAD2, GAD1
8
Show member pathways
10.0GAD2, GAD1
9
Show member pathways
Type III interferon signaling38
9.8TPO, IL6, IFNG
109.8ENO1, IFNG, IL6
11
Show member pathways
9.7GSR, TG, TPO
12
Show member pathways
thioredoxin pathway38
9.7GSR, IFNG, IL6
139.7ENO1, GAD2, BRSK2
14
Show member pathways
9.3GRIA1, GRIN2B, GAD1, GAD2
15
Show member pathways
9.3GAD2, GRIA1, GRIN2B, GAD1
16
Show member pathways
9.3GAD2, GRIA1, GRIN2B, GAD1
17
Show member pathways
9.1IFNG, GAD2, TG, TPO, IL6, GAD1
18
Show member pathways
8.6GRIN2B, PPP1R9B, TPO, IFNG, IL6
198.2BRSK2, GRIA1, GRIN2B, GAD1, GAD2, PPP1R9B

Compounds for genes affiliated with Limbic Encephalitis

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45Novoseek, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 11DrugBank, 51PharmGKB
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Compounds related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1iodotyrosine45 2411.5TG, TPO
2diiodotyrosine4510.4TG, TPO
3perchlorate4510.4TPO, TG
4Cysteic acid2410.4GAD2, GAD1
518f fluorodeoxyglucose4510.3TG, GAD1
6cysteine sulfinic acid4510.3GAD2, GAD1
7bucillamine4510.3IFNG, IL6
8hypotaurine61 45 2412.3GAD1, GAD2
9gamma globulin4510.3TG, IFNG
10sodium iodide4510.3TPO, TG
11guaiacol45 2411.2TPO, GSR
12vesnarinone4510.2IFNG, IL6
13atpo29 4511.2TPO, GRIA1
14taurine chloramine4510.2IFNG, IL6
153-amino-1,2,4-triazole4510.2GSR, TG
16gliadin4510.2GAD2, TG, TPO
17propylthiouracil45 3 1112.2TPO, TG
18125i4510.2TPO, TG, GAD2
19chromium4510.2GSR, TG, TPO
20ivig4510.2TG, IFNG, IL6
21methimazole45 3 1112.1GSR, TG, TPO
22c-peptide4510.1TPO, GAD1, GAD2
233-Sulfinoalanine24 1111.1GAD2, GAD1, GSR
24selenium45 2411.1TPO, TG, GSR
25d penicillamine4510.1IFNG, GSR
26melphalan45 51 1112.0GSR, IL6, IFNG
27prednisolone45 29 1112.0GAD1, IL6, IFNG, TG
28hydrocortisone45 3 61 1113.0TPO, TG, IFNG, IL6
29gold459.9GAD1, TG, TPO
30ebselen459.8GSR, IFNG
31alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid459.8GRIA1, GSR
32aspartate459.7TPO, TG, GSR, GAD1, ENO1
33cyclosporin a45 29 6111.7TG, IFNG, IL6, GAD1, GAD2
34gaba459.7GAD2, GAD1, GRIA1, GSR
35genistein45 29 61 3 24 1114.7TPO, TG, IFNG, IL6, GSR
36creatinine459.5TPO, TG, IL6, GSR, GAD1, ENO1
37glutamine459.5TG, GRIA1, GAD1, ENO1
38acetylcholine45 51 29 24 1113.5TPO, TG, AMPH, GAD1, GAD2
39l-glutamic acid29 24 1111.4GSR, GRIA1, GRIN2B, GAD1, GAD2
40kainate45 2910.4GSR, GRIA1, GRIN2B, GAD1, GAD2
41alanine459.4TG, IL6, GSR, GAD1, GAD2
42nmda45 2910.4GSR, GRIA1, GRIN2B, GAD1, GAD2
43cysteine459.2TPO, TG, IFNG, GSR, GAD1, GAD2
44arginine459.2TPO, TG, IFNG, GSR, GRIA1, GAD1
45lactate459.2TG, IL6, GSR, ENO1
46nitric oxide45 24 1111.0TPO, IFNG, IL6, GRIA1, GRIN2B, GAD1
47dopamine45 29 24 1111.8PPP1R9B, GRIA1, GRIN2B, GAD1, GAD2
48tyrosine458.7SH2D1A, TPO, TG, IL6, GRIA1, GRIN2B
49calcium45 51 24 1111.4SH2D1A, TPO, AMPH, GRIA1, GRIN2B, GAD1
50glutamate457.4ENO1, PPP1R9B, TPO, TG, AMPH, GSR

GO Terms for genes affiliated with Limbic Encephalitis

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16Gene Ontology
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Cellular components related to Limbic Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.0GAD2, GAD1
2synaptic vesicleGO:0080219.1AMPH, GRIA1, GRIN2B
3extracellular spaceGO:0056158.8TPO, TG, LGI1, IFNG, IL6, ENO1
4cell junctionGO:0300548.7GAD2, GRIN2B, GRIA1, LGI1, AMPH

Biological processes related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylation to succinateGO:00654010.2GAD2, GAD1
2neutrophil apoptotic processGO:00178110.2IFNG, IL6
3hormone biosynthetic processGO:04244610.2TG, TPO
4thyroid hormone generationGO:00659010.1TG, TPO
5neurotransmitter biosynthetic processGO:04213610.0GAD1, GAD2
6humoral immune responseGO:0069599.9IL6, IFNG, SH2D1A
7defense response to protozoanGO:0428329.9IL6, IFNG
8ionotropic glutamate receptor signaling pathwayGO:0352359.8GRIN2B, GRIA1
9response to drugGO:0424939.7IFNG, IL6, GAD1, GAD2
10nucleobase-containing small molecule interconversionGO:0159499.3GSR, AK5
11synaptic transmissionGO:0072689.0GAD2, GAD1, GRIN2B, GRIA1, AMPH

Molecular functions related to Limbic Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylase activityGO:00435110.0GAD2, GAD1
2extracellular-glutamate-gated ion channel activityGO:0052349.8GRIN2B, GRIA1
3glutamate bindingGO:0165959.7GAD2, GAD1
4protein bindingGO:0055155.8PPP1R9B, PNMA2, SH2D1A, AMPH, ADAM22, LGI1

Products for genes affiliated with Limbic Encephalitis

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Sources for Limbic Encephalitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet