MCID: LMB024
MIFTS: 49

Limbic Encephalitis malady

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Summaries for Limbic Encephalitis

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NIH Rare Diseases:42 Limbic encephalitis is a condition marked by the inflammation of the limbic system and other parts of the brain. the cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. the symptoms typically develop over a few weeks or months, but they may evolve over a few days. delayed diagnosis is common, but improvements are being made to assist in early detection. early diagnosis may improve the outcome of limbic encephalitis. last updated: 6/8/2009

MalaCards based summary: Limbic Encephalitis is related to encephalitis and paraneoplastic syndromes. An important gene associated with Limbic Encephalitis is GAD1 (glutamate decarboxylase 1 (brain, 67kDa)), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Cytokines and Inflammatory Response. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and temporal lobe, and related mouse phenotypes are normal and endocrine/exocrine gland.

Wikipedia:65 Limbic encephalitis is a form of encephalitis, a disease characterised by inflammation of the brain.... more...

Aliases & Classifications for Limbic Encephalitis

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS
See all sources

Limbic Encephalitis, Aliases & Descriptions:

Name: Limbic Encephalitis 42 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Limbic Encephalitis

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Diseases related to Limbic Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis32.3GAD2, PNMA2, AMPH, LGI1
2paraneoplastic syndromes30.8AMPH, IL6
3stiff-person syndrome30.6GAD1, GAD2, AMPH
4thyroiditis30.6TG, TPO, GAD2
5multiple sclerosis30.6IFNG, GSR, GAD1, IL6
6temporal lobe epilepsy30.5GRIN2B, GAD2, GAD1, LGI1
7systemic lupus erythematosus30.5IFNG, TPO, IL6, ENO1
8alzheimer's disease29.9GRIN2B, GSR, GRIA1, IL6, GAD1
9epilepsy syndrome29.4GRIA1, GSR, GRIN2B, LGI1, GAD2, GAD1
10non-herpetic acute limbic encephalitis10.7
11teratoma10.7
12thymoma10.6
13neuronitis10.6
14lung cancer10.6
15relapsing polychondritis10.5
16status epilepticus10.5
17pernicious anemia10.5TG, TPO
18subacute thyroiditis10.5TPO, TG
19toxic diffuse goiter10.4TG, TPO
20endemic goiter10.4TG, TPO
21nontoxic goiter10.4TPO, TG
22plummer's disease10.4TPO, TG
23multinodular goiter10.4TG, TPO
24myxedema10.4TG, TPO
25thyrotropin deficiency, isolated10.4TPO, TG
26adenocarcinoma10.4
27testicular cancer10.4
28limbic encephalitis with dpp6 antibodies10.4
29autoimmune thyroiditis10.4TG, TPO
30thyrotoxicosis10.4TPO, TG
31autosomal dominant hyper ige syndrome10.4IL6, IFNG
32nodular goiter10.4TG, TPO
33pendred syndrome10.4TG, TPO
34premature ovarian failure10.4TPO, ENO1
35hypothyroidism10.4TG, TPO
36rasmussen encephalitis10.4GAD1, GSR
37diabetic ketoacidosis10.4GAD2, GAD1
38breast cancer10.4
39dementia10.4
40prostatitis10.4
41classic paraneoplastic limbic encephalitis10.4
42limbic encephalitis with lgi1 antibodies10.4
43limbic encephalitis with ncmags antibodies10.4
44posttransplant acute limbic encephalitis10.4
45limbic encephalitis with nmda receptor antibodies10.4
46turner syndrome10.3TPO, TG
47autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.3GAD1, GAD2
48follicular thyroid carcinoma10.3TPO, TG
49diabetic neuropathy10.3GAD2, GAD1
50papillary thyroid carcinoma10.3TG, TPO

Graphical network of the top 20 diseases related to Limbic Encephalitis:



Diseases related to limbic encephalitis

Symptoms for Limbic Encephalitis

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Drugs & Therapeutics for Limbic Encephalitis

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Drug clinical trials:

Search ClinicalTrials for Limbic Encephalitis

Search NIH Clinical Center for Limbic Encephalitis

Genetic Tests for Limbic Encephalitis

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Anatomical Context for Limbic Encephalitis

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MalaCards organs/tissues related to Limbic Encephalitis:

32
Brain, Lung, Temporal lobe, Bone marrow, Bone, Colon, Breast, Prostate, Eye, Spinal cord, Thyroid, Myeloid, Monocytes, B cells, Amygdala, Neutrophil

Animal Models for Limbic Encephalitis or affiliated genes

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MGI Mouse Phenotypes related to Limbic Encephalitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.8IFNG, GSR, GRIA1, GAD1, GAD2, BRSK2
2MP:00053798.3IL6, TG, TPO, AMPH, IFNG, GAD2
3MP:00053786.9PPP1R9B, TPO, TG, GAD2, GAD1, GRIN2B
4MP:00107686.9ELAVL3, AMPH, BRSK2, ADAM22, GAD1, GRIN2B
5MP:00053766.8PPP1R9B, SH2D1A, TPO, GAD2, GAD1, GRIN2B
6MP:00053866.2GRIA1, IL6, IFNG, LGI1, ADAM22, GRIN2B
7MP:00036316.0GRIA1, PPP1R9B, GAD2, GAD1, GRIN2B, IL6

Publications for Limbic Encephalitis

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Articles related to Limbic Encephalitis:

(show top 50)    (show all 377)
idTitleAuthorsYear
1
Limbic encephalitis due to GABAB and AMPA receptor antibodies: a case series. (25300449)
2014
2
Mature ovarian teratoma-associated limbic encephalitis. (25093683)
2014
3
Autoimmune limbic encephalitis and anesthesia. (24104946)
2013
4
Limbic encephalitis: a clinical-radiological comparison between herpetic and autoimmune etiologies. (23941332)
2013
5
Correlative imaging with (18)F-FDG PET/CT and MRI in paraneoplastic limbic encephalitis. (23531769)
2013
6
Voltage-gated potassium channel antibody paraneoplastic limbic encephalitis associated with acute myeloid leukemia. (23898271)
2013
7
Limbic Encephalitis Associated With Elevated Antithyroid Antibodies. (23520363)
2013
8
Autoimmune limbic encephalitis presenting as relapsing psychosis. (23997078)
2013
9
Limbic encephalitis in a child: an atypical presentation. (24095576)
2013
10
The diagnosis and treatment of limbic encephalitis. (22713136)
2012
11
Surgical control of limbic encephalitis associated with LGI1 antibodies. (22940785)
2012
12
Two different 18F-FDG brain PET metabolic patterns in autoimmune limbic encephalitis. (22889795)
2012
13
Cord-blood hematopoietic stem cell transplantA confers an increased risk for human herpesvirus-6-associated acute limbic encephalitis: aA cohort analysis. (22564265)
2012
14
Proposition: limbic encephalitis may represent limbic status epilepticus. A review of clinical and EEG characteristics. (22459869)
2012
15
A boy with non-herpes simplex acute limbic encephalitis and antiglutamate receptor antibodies. (22084613)
2011
16
Continuous muscle activity, Morvan's syndrome and limbic encephalitis: ionic or non ionic disorders? (21842591)
2011
17
Autoimmune Limbic Encephalitis With GAD Antibodies. (23983853)
2011
18
Recognition of faciobrachial dystonic seizures allowing early intervention with and prevention of development of full-blown limbic encephalitis. (22319790)
2011
19
Steroid-responsive recurrent limbic encephalitis associated with small cell lung cancer and neuropil antibodies. (21748934)
2011
20
Paraneoplastic syndrome of inappropriate antidiuretic hormone mimicking limbic encephalitis. (22159058)
2011
21
An effective immunotherapy regimen for VGKC antibody-positive limbic encephalitis. (20660916)
2010
22
Non-paraneoplastic limbic encephalitis associated with NMDAR and VGKC antibodies. (20667865)
2010
23
Limbic encephalitis associated with systemic lupus erythematosus. (19850655)
2009
24
Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis. (19716567)
2009
25
Voltage-gated potassium channel-associated limbic encephalitis in the West of Scotland: case reports and literature review. (20034278)
2009
26
An autopsy case with non-herpetic acute limbic encephalitis (NHALE). (18282167)
2008
27
Paraneoplastic limbic encephalitis as a cause of new onset of seizures in a patient with non-small cell lung carcinoma: a case report. (18700972)
2008
28
Acute limbic encephalitis: diagnostic and management implications. (18197513)
2008
29
Limbic encephalitis as presentation of a SAP deficiency. (17620557)
2007
30
Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. (17620548)
2007
31
Complex partial status epilepticus in paraneoplastic limbic encephalitis. (17844948)
2007
32
Limbic encephalitis--an uncommon presentation of systemic malignancy. (18173029)
2007
33
Limbic encephalitis: extension of the diagnostic armamentarium. (17018560)
2007
34
Limbic encephalitis: another example of molecular mimicry? (17389799)
2007
35
Anti-Hu-associated paraneoplastic limbic encephalitis presenting as rapidly progressive non-convulsive status epilepticus. (16631204)
2006
36
Reversible paraneoplastic limbic encephalitis caused by a benign ovarian teratoma: report of a case and review of literatures. (16944314)
2006
37
Electroconvulsive therapy in a pediatric patient with malignant catatonia and paraneoplastic limbic encephalitis. (17143159)
2006
38
Paraneoplastic limbic encephalitis. (15708228)
2005
39
Neurosyphilis and paraneoplastic limbic encephalitis: important differential diagnoses. (15789128)
2005
40
Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. (15888538)
2005
41
A pre-senile case of limbic encephalitis and cerebellar degeneration, with subacute onset of progressive dementia. (15673963)
2004
42
Non-herpetic acute limbic encephalitis: a new subgroup of limbic encephalitis? (15168784)
2004
43
Resolution of limbic encephalitis with detection and treatment of lung cancer: clinical-radiological correlation. (12499067)
2003
44
Asessment of paraneoplastic limbic encephalitis in testicular cancer. (12846502)
2003
45
Paraneoplastic limbic encephalitis masquerading as chronic behavioural disturbance in an adolescent girl. (12801123)
2003
46
Hypermetabolism of the medial temporal lobe in limbic encephalitis on (18)FDG-PET scan: a case report. (11306867)
2001
47
Varicella-zoster virus limbic encephalitis in an immunocompromised patient. (11728054)
2001
48
Paraneoplastic limbic encephalitis should not be overlooked as a possible cause of delirium in cancer patients. (11025799)
2000
49
Limbic encephalitis. A rare presentation of the small-cell lung carcinoma. (2553530)
1989
50
Small-cell lung cancer and limbic encephalitis. (6283978)
1982

Variations for Limbic Encephalitis

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Expression for genes affiliated with Limbic Encephalitis

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Expression patterns in normal tissues for genes affiliated with Limbic Encephalitis

Search GEO for disease gene expression data for Limbic Encephalitis.

Pathways for genes affiliated with Limbic Encephalitis

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Pathways related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TPO, TG
210.0IFNG, IL6
310.0IFNG, IL6
4
Show member pathways
catecholamine biosynthesis37
10.0GAD1, GAD2
510.0GAD1, GAD2
6
Show member pathways
10.0GAD1, GAD2
7
Show member pathways
10.0GAD2, GAD1
8
Show member pathways
10.0GAD2, GAD1
9
Show member pathways
Type III interferon signaling37
9.8TPO, IL6, IFNG
109.8ENO1, IFNG, IL6
11
Show member pathways
9.7GSR, TG, TPO
12
Show member pathways
thioredoxin pathway37
9.7GSR, IFNG, IL6
139.7ENO1, GAD2, BRSK2
14
Show member pathways
9.3GRIA1, GRIN2B, GAD1, GAD2
15
Show member pathways
9.3GAD2, GRIA1, GRIN2B, GAD1
16
Show member pathways
9.3GAD2, GRIA1, GRIN2B, GAD1
17
Show member pathways
9.1IFNG, GAD2, TG, TPO, IL6, GAD1
18
Show member pathways
8.6GRIN2B, PPP1R9B, TPO, IFNG, IL6
198.2BRSK2, GRIA1, GRIN2B, GAD1, GAD2, PPP1R9B

Compounds for genes affiliated with Limbic Encephalitis

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Compounds related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1iodotyrosine44 2411.5TPO, TG
2diiodotyrosine4410.4TPO, TG
3perchlorate4410.4TG, TPO
4Cysteic acid2410.4GAD1, GAD2
518f fluorodeoxyglucose4410.3TG, GAD1
6gamma globulin4410.3IFNG, TG
7cysteine sulfinic acid4410.3GAD1, GAD2
8bucillamine4410.3IL6, IFNG
9hypotaurine61 44 2412.3GAD1, GAD2
10sodium iodide4410.3TPO, TG
11vesnarinone4410.2IFNG, IL6
12guaiacol44 2411.2TPO, GSR
13atpo28 4411.2GRIA1, TPO
14taurine chloramine4410.2IFNG, IL6
153-amino-1,2,4-triazole4410.2GSR, TG
16gliadin4410.2GAD2, TPO, TG
17propylthiouracil44 2 1112.2TPO, TG
18125i4410.2TPO, GAD2, TG
19chromium4410.2TG, TPO, GSR
20ivig4410.2TG, IFNG, IL6
21methimazole44 2 1112.1TG, GSR, TPO
22c-peptide4410.1GAD2, TPO, GAD1
233-Sulfinoalanine24 1111.1GSR, GAD1, GAD2
24selenium44 2411.1GSR, TG, TPO
25d penicillamine4410.1IFNG, GSR
26melphalan44 50 1112.0IL6, IFNG, GSR
27prednisolone44 28 1112.0GAD1, IL6, IFNG, TG
28hydrocortisone44 2 61 1113.0TG, IL6, TPO, IFNG
29gold449.9TG, TPO, GAD1
30ebselen449.8IFNG, GSR
31alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid449.8GSR, GRIA1
32aspartate449.7TPO, TG, GSR, GAD1, ENO1
33cyclosporin a44 28 6111.7IFNG, GAD2, IL6, GAD1, TG
34gaba449.7GSR, GRIA1, GAD1, GAD2
35genistein44 28 61 2 24 1114.7TPO, IL6, IFNG, TG, GSR
36creatinine449.5TPO, ENO1, TG, GAD1, IL6, GSR
37glutamine449.5GRIA1, GAD1, TG, ENO1
38acetylcholine44 50 28 24 1113.5GAD2, GAD1, AMPH, TG, TPO
39l-glutamic acid28 24 1111.4GAD1, GSR, GAD2, GRIN2B, GRIA1
40kainate44 2810.4GSR, GAD2, GAD1, GRIN2B, GRIA1
41alanine449.4GAD1, GAD2, IL6, GSR, TG
42nmda44 2810.4GRIN2B, GSR, GRIA1, GAD1, GAD2
43cysteine449.2GAD2, ENO1, GAD1, GSR, IFNG, TG
44arginine449.2TPO, TG, IFNG, GSR, GAD1, ENO1
45lactate449.2IL6, GSR, ENO1, TG
46nitric oxide44 24 1111.0GAD2, GAD1, GRIN2B, GRIA1, IL6, IFNG
47dopamine44 28 24 1111.8PPP1R9B, GRIA1, GRIN2B, GAD1, GAD2
48tyrosine448.7GAD2, GAD1, TPO, SH2D1A, TG, IL6
49calcium44 50 24 1111.4AMPH, GRIA1, GRIN2B, GAD1, GAD2, SH2D1A
50glutamate447.4GRIA1, PPP1R9B, TPO, ENO1, GAD2, GAD1

GO Terms for genes affiliated with Limbic Encephalitis

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Cellular components related to Limbic Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.0GAD2, GAD1
2synaptic vesicleGO:0080219.1AMPH, GRIA1, GRIN2B
3extracellular spaceGO:0056158.8TPO, TG, LGI1, IFNG, IL6, ENO1
4cell junctionGO:0300548.7GAD2, GRIN2B, GRIA1, LGI1, AMPH

Biological processes related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylation to succinateGO:00654010.2GAD2, GAD1
2neutrophil apoptotic processGO:00178110.2IFNG, IL6
3hormone biosynthetic processGO:04244610.2TG, TPO
4thyroid hormone generationGO:00659010.1TG, TPO
5neurotransmitter biosynthetic processGO:04213610.0GAD1, GAD2
6humoral immune responseGO:0069599.9IL6, IFNG, SH2D1A
7defense response to protozoanGO:0428329.9IL6, IFNG
8ionotropic glutamate receptor signaling pathwayGO:0352359.8GRIN2B, GRIA1
9response to drugGO:0424939.7IFNG, IL6, GAD1, GAD2
10nucleobase-containing small molecule interconversionGO:0159499.3GSR, AK5
11synaptic transmissionGO:0072689.0GAD2, GAD1, GRIN2B, GRIA1, AMPH

Molecular functions related to Limbic Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylase activityGO:00435110.0GAD2, GAD1
2extracellular-glutamate-gated ion channel activityGO:0052349.8GRIN2B, GRIA1
3glutamate bindingGO:0165959.7GAD2, GAD1
4protein bindingGO:0055155.8PPP1R9B, PNMA2, SH2D1A, AMPH, ADAM22, LGI1

Products for genes affiliated with Limbic Encephalitis

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Sources for Limbic Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet