MCID: LMB024
MIFTS: 37

Limbic Encephalitis malady

Neuronal diseases category

Summaries for Limbic Encephalitis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Limbic encephalitis is a condition marked by the inflammation of the limbic system and other parts of the brain. the cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. the symptoms typically develop over a few weeks or months, but they may evolve over a few days. delayed diagnosis is common, but improvements are being made to assist in early detection. early diagnosis may improve the outcome of limbic encephalitis. last updated: 6/8/2009

MalaCards: Limbic Encephalitis is related to encephalitis and status epilepticus. An important gene associated with Limbic Encephalitis is GAD1 (glutamate decarboxylase 1 (brain, 67kDa)), and among its related pathways are Taurine and hypotaurine metabolism and GABA synthesis. The compounds melphalan and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Wikipedia:63 Limbic encephalitis is a form of encephalitis, a disease characterised by inflammation of the brain.... more...

Aliases & Classifications for Limbic Encephalitis

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42NIH Rare Diseases, 44Novoseek, 48Orphanet, 60UMLS, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

limbic encephalitis 42 44 48 60


External Ids:

MESH via Orphanet35 D020363
SNOMED-CT via Orphanet57 230192003
UMLS via Orphanet61 C0338430

Related Diseases for Limbic Encephalitis

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17GeneCards, 18GeneDecks
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Diseases related to Limbic Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis32.0LGI1, PNMA2, GAD2, AMPH
2status epilepticus30.7GAD1
3adenocarcinoma30.5ENO1
4temporal lobe epilepsy30.5LGI1, GRIN2B, GAD1, GAD2
5breast cancer30.4GSR, ENO1, GAD1, AMPH
6myasthenia gravis30.3IFNG
7herpes simplex30.3ENO1, GAD1
8multiple sclerosis30.3IFNG, GAD1, IL6, GSR
9alzheimer's disease30.3GAD1, GRIN2B, GRIA1, IL6, GSR
10pancreatitis30.1IL6
11focal epilepsy30.1LGI1
12common variable immune deficiency30.1SH2D1A
13stiff-person syndrome30.1GAD1, GAD2, AMPH
14encephalomyelitis30.1GAD1, GAD2, IFNG
15thyroiditis30.1GAD2, TPO, TG
16systemic lupus erythematosus30.1TPO, ENO1, IL6, IFNG
17epilepsy syndrome30.0GAD2, GAD1, GRIN2B, GRIA1, LGI1, GSR
18thymoma10.6
19neuronitis10.6
20lung cancer10.5
21relapsing polychondritis10.5
22small cell carcinoma10.5
23lung small cell carcinoma10.4
24testicular cancer10.4
25dementia10.3
26prostatitis10.3
27sleep disorder10.3
28classic paraneoplastic limbic encephalitis10.3
29limbic encephalitis with lgi1 antibodies10.3
30limbic encephalitis with ncmags antibodies10.3
31limbic encephalitis with nmda receptor antibodies10.3
32limbic encephalitis with dpp6 antibodies10.3
33viral encephalitis10.2
34anterograde amnesia10.2
35cerebellar ataxia10.2
36colon adenocarcinoma10.2
37leukemia10.2
38prostate cancer10.2
39non-herpetic acute limbic encephalitis10.2
40posttransplant acute limbic encephalitis10.2
41limbic encephalitis with caspr2 antibodies10.2
42non-hodgkin lymphoma10.1
43subacute sclerosing panencephalitis10.1
44narcolepsy10.1
45prostate small cell carcinoma10.1
46syphilitic encephalitis10.1
47lambert-eaton myasthenic syndrome10.1
48cerebritis10.1
49primary biliary cirrhosis10.1
50acute myeloid leukemia10.1

Graphical network of the top 20 diseases related to Limbic Encephalitis:



Diseases related to limbic encephalitis

Clinical Features for Limbic Encephalitis

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Drugs & Therapeutics for Limbic Encephalitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Limbic Encephalitis

Drug clinical trials:

Search ClinicalTrials for Limbic Encephalitis

Search NIH Clinical Center for Limbic Encephalitis

Search CenterWatch for Limbic Encephalitis

Genetic Tests for Limbic Encephalitis

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Anatomical Context for Limbic Encephalitis

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32MalaCards
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MalaCards organs/tissues related to Limbic Encephalitis:

32
Brain

Animal Models for Limbic Encephalitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Limbic Encephalitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2IL6, GAD1, GAD2, IFNG, AMPH, TPO
2MP:00107687.3GAD1, BRSK2, AMPH, IFNG, ELAVL3, TPO
3MP:00053787.0TG, IFNG, PPP1R9B, GAD2, GAD1, GRIN2B
4MP:00053766.7GAD2, PPP1R9B, TG, GAD1, SH2D1A, GRIN2B
5MP:00053866.4IL6, GRIA1, GAD1, LGI1, ELAVL3, GAD2
6MP:00036316.2TG, IFNG, PPP1R9B, GAD2, GAD1, GRIN2B

Publications for Limbic Encephalitis

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Genetic Variations for Limbic Encephalitis

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Expression for genes affiliated with Limbic Encephalitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Limbic Encephalitis

Search GEO for disease gene expression data for Limbic Encephalitis.

Pathways for genes affiliated with Limbic Encephalitis

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29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0GAD1, GAD2
210.0GAD1, GAD2
310.0GAD1, GAD2
410.0GAD2, GAD1
59.8IFNG, IL6, ENO1
6
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9.7TPO, GAD1, GAD2
7
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9.7TG, GSR, TPO
89.6IFNG, IL6, GSR
9
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9.5IFNG, GAD2, GAD1, IL6
109.2GAD2, GAD1, GRIN2B, GRIA1
11
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9.2GRIA1, GRIN2B, GAD1, GAD2
12
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8.5TPO, IL6, GRIN2B, PPP1R9B, IFNG
138.0BRSK2, PPP1R9B, GAD2, GAD1, GRIN2B, GRIA1

Compounds for genes affiliated with Limbic Encephalitis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB, 49PharmGKB
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Compounds related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1melphalan44 1111.4GSR
2iodotyrosine44 2411.4TG, TPO
3diiodotyrosine4410.4TPO, TG
4perchlorate4410.3TPO, TG
5bucillamine4410.2IFNG, IL6
6cysteine sulfinic acid4410.2GAD1, GAD2
7hypotaurine59 44 2412.2GAD2, GAD1
818f fluorodeoxyglucose4410.2GAD1, TG
9gamma globulin4410.2IFNG, TG
10aspartate4410.2TG, TPO, GAD1
11guaiacol44 2411.1TPO, GSR
12atpo44 2811.1GRIA1, TPO
13gliadin4410.1GAD2, TPO, TG
14chromium4410.1TG, GSR, TPO
15125i4410.1TG, TPO, GAD2
16ivig4410.1IFNG, IL6, TG
17methimazole44 2 1112.1TG, GSR, TPO
183-amino-1,2,4-triazole4410.0GSR, TG
19taurine chloramine4410.0IFNG, IL6
20c-peptide4410.0TPO, GAD1, GAD2
213-Sulfinoalanine11 2411.0GAD2, GAD1, GSR
22selenium44 2411.0TG, GSR, TPO
23vesnarinone4410.0IFNG, IL6
24prednisolone44 28 1111.9IFNG, GAD1, IL6, TG
25sodium iodide449.9TPO, TG
26hydrocortisone44 2 59 1112.9TG, TPO, IL6, IFNG
27d penicillamine449.9GSR, IFNG
28propylthiouracil44 2 1111.7TG, TPO
29acetylcholine44 49 28 11 2413.6AMPH, GAD2, GAD1, TPO
30cyclosporin a44 28 5911.6IFNG, GAD2, GAD1, IL6, TG
31genistein44 28 59 2 11 2414.6IFNG, IL6, TPO, GSR, TG
32gaba449.6GAD2, GAD1, GRIA1, GSR
33creatinine449.4GAD1, IL6, ENO1, TPO, GSR, TG
34l-glutamic acid28 11 2411.3GAD2, GAD1, GRIN2B, GRIA1, GSR
35kainate44 2810.3GSR, GRIA1, GRIN2B, GAD1, GAD2
36nmda44 2810.2GAD2, GAD1, GRIN2B, GRIA1, GSR
37cysteine449.1IFNG, GAD2, GAD1, ENO1, TPO, GSR
38arginine449.1IFNG, GAD1, GRIA1, ENO1, TPO, GSR
39nitric oxide44 11 2410.9IFNG, GAD2, GAD1, GRIN2B, GRIA1, IL6
40dopamine44 28 11 2411.7PPP1R9B, GAD2, GAD1, GRIN2B, GRIA1
41tyrosine448.6GAD2, GAD1, SH2D1A, GRIN2B, GRIA1, IL6
42calcium44 49 11 2411.1AMPH, GAD2, GAD1, SH2D1A, GRIN2B, GRIA1
43glutamate447.3TG, AMPH, PPP1R9B, GAD2, GAD1, GRIN2B

GO Terms for genes affiliated with Limbic Encephalitis

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16Gene Ontology
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Cellular components related to Limbic Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.0GAD1, GAD2
2synaptic vesicleGO:0080218.9GRIA1, AMPH, GRIN2B
3cell junctionGO:0300548.5GRIN2B, AMPH, GAD2, LGI1, GRIA1

Biological processes related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1neutrophil apoptotic processGO:00178110.2IL6, IFNG
2glutamate decarboxylation to succinateGO:00654010.2GAD1, GAD2
3hormone biosynthetic processGO:04244610.0TG, TPO
4defense response to protozoanGO:04283210.0IL6, IFNG
5thyroid hormone generationGO:0065909.9TPO, TG
6humoral immune responseGO:0069599.9IL6, SH2D1A, IFNG
7neurotransmitter biosynthetic processGO:0421369.7GAD1, GAD2
8response to drugGO:0424939.5IFNG, GAD2, GAD1, IL6
9synaptic transmissionGO:0072688.8AMPH, GAD2, GAD1, GRIN2B, GRIA1

Molecular functions related to Limbic Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate bindingGO:01659510.0GAD1, GAD2
2glutamate decarboxylase activityGO:0043519.7GAD1, GAD2

Products for genes affiliated with Limbic Encephalitis

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  • Antibodies
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Sources for Limbic Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet