MCID: LMB024
MIFTS: 42

Limbic Encephalitis malady

Rare diseases category

Aliases & Classifications for Limbic Encephalitis

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Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS
See all sources

Limbic Encephalitis, Aliases & Descriptions:

Name: Limbic Encephalitis 41 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Summaries for Limbic Encephalitis

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NIH Rare Diseases:41 Limbic encephalitis is a condition marked by the inflammation of the limbic system and other parts of the brain. the cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. the symptoms typically develop over a few weeks or months, but they may evolve over a few days. delayed diagnosis is common, but improvements are being made to assist in early detection. early diagnosis may improve the outcome of limbic encephalitis. last updated: 6/8/2009

MalaCards based summary: Limbic Encephalitis is related to encephalitis and paraneoplastic syndromes. An important gene associated with Limbic Encephalitis is GAD1 (glutamate decarboxylase 1 (brain, 67kDa)), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Immune response MIF mediated glucocorticoid regulation. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and temporal lobe, and related mouse phenotypes are normal and endocrine/exocrine gland.

Wikipedia:63 Limbic encephalitis is a form of encephalitis, a disease characterised by inflammation of the brain.... more...

Related Diseases for Limbic Encephalitis

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Diseases related to Limbic Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis32.3PNMA2, AMPH, LGI1, GAD2
2paraneoplastic syndromes31.1IL6, AMPH
3stiff-person syndrome30.6AMPH, GAD1, GAD2
4thyroiditis30.6GAD2, TG, TPO
5temporal lobe epilepsy30.5LGI1, GRIN2B, GAD1, GAD2
6systemic lupus erythematosus30.5TPO, IFNG, IL6, ENO1
7epilepsy syndrome29.4LGI1, GSR, GRIA1, GRIN2B, GAD1, GAD2
8non-herpetic acute limbic encephalitis10.7
9teratoma10.7
10neuronitis10.6
11thymoma10.6
12lung cancer10.6
13status epilepticus10.6
14relapsing polychondritis10.5
15limbic encephalitis with dpp6 antibodies10.5
16goiter, multinodular 1, with or without sertoli-leydig cell tumors10.5TPO, TG
17subacute thyroiditis10.4TPO, TG
18pernicious anemia10.4TPO, TG
19toxic diffuse goiter10.4TPO, TG
20endemic goiter10.4TG, TPO
21plummer's disease10.4TG, TPO
22nontoxic goiter10.4TG, TPO
23multinodular goiter10.4TPO, TG
24hodgkin lymphoma10.4
25adenocarcinoma10.4
26dementia10.4
27testicular cancer10.4
28classic paraneoplastic limbic encephalitis10.4
29limbic encephalitis with lgi1 antibodies10.4
30limbic encephalitis with ncmags antibodies10.4
31posttransplant acute limbic encephalitis10.4
32limbic encephalitis with nmda receptor antibodies10.4
33hypothryoidism, congenital, nongoitrous 410.4TPO, TG
34myxedema10.4TPO, TG
35autoimmune thyroiditis10.4TG, TPO
36hyper-ige recurrent infection syndrome10.4IL6, IFNG
37thyrotoxicosis10.4TPO, TG
38nodular goiter10.4TG, TPO
39premature ovarian failure10.4TPO, ENO1
40rasmussen encephalitis10.4GAD1, GSR
41pendred syndrome10.4TG, TPO
42breast cancer10.4
43prostatitis10.4
44limbic encephalitis with caspr2 antibodies10.4
45diabetic ketoacidosis10.4GAD1, GAD2
46hypothyroidism10.3TPO, TG
47autoimmune polyendocrine syndrome type 110.3GAD1, GAD2
48thyroid carcinoma, follicular10.3TPO, TG
49turner syndrome10.3TPO, TG
50diabetic neuropathy10.3GAD1, GAD2

Graphical network of the top 20 diseases related to Limbic Encephalitis:



Diseases related to limbic encephalitis

Symptoms for Limbic Encephalitis

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Drugs & Therapeutics for Limbic Encephalitis

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Drug clinical trials:

Search ClinicalTrials for Limbic Encephalitis

Search NIH Clinical Center for Limbic Encephalitis

Genetic Tests for Limbic Encephalitis

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Anatomical Context for Limbic Encephalitis

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MalaCards organs/tissues related to Limbic Encephalitis:

31
Brain, Lung, Temporal lobe, Bone marrow, Bone, Colon, Breast, Prostate, Eye, Spinal cord, Thyroid, Myeloid, Monocytes, B cells, Amygdala, Neutrophil

Animal Models for Limbic Encephalitis or affiliated genes

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MGI Mouse Phenotypes related to Limbic Encephalitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.8GAD2, GAD1, GRIA1, GSR, IFNG, BRSK2
2MP:00053798.3TPO, TG, AMPH, IFNG, IL6, GAD1
3MP:00053786.9PPP1R9B, TPO, TG, ADAM22, LGI1, IFNG
4MP:00107686.9ADAM22, BRSK2, AMPH, TPO, ELAVL3, LGI1
5MP:00053766.8TG, TPO, SH2D1A, PPP1R9B, ELAVL3, IFNG
6MP:00053866.2ELAVL3, ADAM22, BRSK2, AMPH, PPP1R9B, LGI1
7MP:00036316.0GAD2, PPP1R9B, TG, AMPH, BRSK2, ADAM22

Publications for Limbic Encephalitis

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Articles related to Limbic Encephalitis:

(show top 50)    (show all 395)
idTitleAuthorsYear
1
Uncommon 18F-FDG-PET/CT findings in patients affected by limbic encephalitis: hyper-hypometabolic pattern with double antibody positivity and migrating foci of hypermetabolism. (25487436)
2015
2
Limbic encephalitis associated with relapsing polychondritis responded to infliximab and maintained its condition without recurrence after discontinuation: a case report and review of the literature. (25741046)
2014
3
Limbic encephalitis due to GABAB and AMPA receptor antibodies: a case series. (25300449)
2014
4
Mature ovarian teratoma-associated limbic encephalitis. (25093683)
2014
5
Autoimmune limbic encephalitis and anesthesia. (24104946)
2013
6
Limbic encephalitis: a clinical-radiological comparison between herpetic and autoimmune etiologies. (23941332)
2013
7
Correlative imaging with (18)F-FDG PET/CT and MRI in paraneoplastic limbic encephalitis. (23531769)
2013
8
Voltage-gated potassium channel antibody paraneoplastic limbic encephalitis associated with acute myeloid leukemia. (23898271)
2013
9
Limbic Encephalitis Associated With Elevated Antithyroid Antibodies. (23520363)
2013
10
Autoimmune limbic encephalitis presenting as relapsing psychosis. (23997078)
2013
11
Limbic encephalitis in a child: an atypical presentation. (24095576)
2013
12
The diagnosis and treatment of limbic encephalitis. (22713136)
2012
13
Surgical control of limbic encephalitis associated with LGI1 antibodies. (22940785)
2012
14
Two different 18F-FDG brain PET metabolic patterns in autoimmune limbic encephalitis. (22889795)
2012
15
Cord-blood hematopoietic stem cell transplantA confers an increased risk for human herpesvirus-6-associated acute limbic encephalitis: aA cohort analysis. (22564265)
2012
16
Proposition: limbic encephalitis may represent limbic status epilepticus. A review of clinical and EEG characteristics. (22459869)
2012
17
A boy with non-herpes simplex acute limbic encephalitis and antiglutamate receptor antibodies. (22084613)
2011
18
Continuous muscle activity, Morvan's syndrome and limbic encephalitis: ionic or non ionic disorders? (21842591)
2011
19
Autoimmune Limbic Encephalitis With GAD Antibodies. (23983853)
2011
20
Recognition of faciobrachial dystonic seizures allowing early intervention with and prevention of development of full-blown limbic encephalitis. (22319790)
2011
21
Steroid-responsive recurrent limbic encephalitis associated with small cell lung cancer and neuropil antibodies. (21748934)
2011
22
An effective immunotherapy regimen for VGKC antibody-positive limbic encephalitis. (20660916)
2010
23
Non-paraneoplastic limbic encephalitis associated with NMDAR and VGKC antibodies. (20667865)
2010
24
Limbic encephalitis associated with systemic lupus erythematosus. (19850655)
2009
25
Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis. (19716567)
2009
26
Voltage-gated potassium channel-associated limbic encephalitis in the West of Scotland: case reports and literature review. (20034278)
2009
27
An autopsy case with non-herpetic acute limbic encephalitis (NHALE). (18282167)
2008
28
Paraneoplastic limbic encephalitis as a cause of new onset of seizures in a patient with non-small cell lung carcinoma: a case report. (18700972)
2008
29
Limbic encephalitis as presentation of a SAP deficiency. (17620557)
2007
30
Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. (17620548)
2007
31
Complex partial status epilepticus in paraneoplastic limbic encephalitis. (17844948)
2007
32
Limbic encephalitis--an uncommon presentation of systemic malignancy. (18173029)
2007
33
Limbic encephalitis: extension of the diagnostic armamentarium. (17018560)
2007
34
Limbic encephalitis: another example of molecular mimicry? (17389799)
2007
35
Anti-Hu-associated paraneoplastic limbic encephalitis presenting as rapidly progressive non-convulsive status epilepticus. (16631204)
2006
36
Reversible paraneoplastic limbic encephalitis caused by a benign ovarian teratoma: report of a case and review of literatures. (16944314)
2006
37
Electroconvulsive therapy in a pediatric patient with malignant catatonia and paraneoplastic limbic encephalitis. (17143159)
2006
38
Paraneoplastic limbic encephalitis. (15708228)
2005
39
Neurosyphilis and paraneoplastic limbic encephalitis: important differential diagnoses. (15789128)
2005
40
Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. (15888538)
2005
41
A pre-senile case of limbic encephalitis and cerebellar degeneration, with subacute onset of progressive dementia. (15673963)
2004
42
Non-herpetic acute limbic encephalitis: a new subgroup of limbic encephalitis? (15168784)
2004
43
Resolution of limbic encephalitis with detection and treatment of lung cancer: clinical-radiological correlation. (12499067)
2003
44
Asessment of paraneoplastic limbic encephalitis in testicular cancer. (12846502)
2003
45
Paraneoplastic limbic encephalitis masquerading as chronic behavioural disturbance in an adolescent girl. (12801123)
2003
46
Hypermetabolism of the medial temporal lobe in limbic encephalitis on (18)FDG-PET scan: a case report. (11306867)
2001
47
Varicella-zoster virus limbic encephalitis in an immunocompromised patient. (11728054)
2001
48
Paraneoplastic limbic encephalitis should not be overlooked as a possible cause of delirium in cancer patients. (11025799)
2000
49
Limbic encephalitis. A rare presentation of the small-cell lung carcinoma. (2553530)
1989
50
Small-cell lung cancer and limbic encephalitis. (6283978)
1982

Variations for Limbic Encephalitis

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Expression for genes affiliated with Limbic Encephalitis

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Search GEO for disease gene expression data for Limbic Encephalitis.

Pathways for genes affiliated with Limbic Encephalitis

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Pathways related to Limbic Encephalitis according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TG, TPO
210.0IL6, IFNG
310.0IFNG, IL6
410.0GAD2, GAD1
5
Show member pathways
catecholamine biosynthesis36
10.0GAD2, GAD1
6
Show member pathways
10.0GAD2, GAD1
7
Show member pathways
10.0GAD1, GAD2
8
Show member pathways
10.0GAD1, GAD2
9
Show member pathways
Type III interferon signaling36
9.8IL6, IFNG, TPO
109.8ENO1, IL6, IFNG
11
Show member pathways
9.7GSR, TG, TPO
12
Show member pathways
thioredoxin pathway36
9.7GSR, IL6, IFNG
139.7ENO1, GAD2, BRSK2
14
Show member pathways
9.3GRIA1, GRIN2B, GAD1, GAD2
15
Show member pathways
9.3GRIA1, GRIN2B, GAD1, GAD2
16
Show member pathways
9.1GAD2, GAD1, IL6, IFNG, TG, TPO
17
Show member pathways
8.6PPP1R9B, TPO, IFNG, IL6, GRIN2B
188.2PPP1R9B, BRSK2, GRIA1, GRIN2B, GAD1, GAD2

Compounds for genes affiliated with Limbic Encephalitis

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Compounds related to Limbic Encephalitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1iodotyrosine43 2411.5TG, TPO
2diiodotyrosine4310.4TG, TPO
3perchlorate4310.4TPO, TG
4Cysteic acid2410.4GAD2, GAD1
518f fluorodeoxyglucose4310.3TG, GAD1
6cysteine sulfinic acid4310.3GAD2, GAD1
7bucillamine4310.3IFNG, IL6
8hypotaurine59 43 2412.3GAD1, GAD2
9gamma globulin4310.3TG, IFNG
10sodium iodide4310.3TPO, TG
11guaiacol43 2411.2TPO, GSR
12vesnarinone4310.2IFNG, IL6
13atpo28 4311.2TPO, GRIA1
14taurine chloramine4310.2IFNG, IL6
153-amino-1,2,4-triazole4310.2GSR, TG
16gliadin4310.2GAD2, TG, TPO
17propylthiouracil43 2 1212.2TPO, TG
18125i4310.2TPO, TG, GAD2
19chromium4310.2GSR, TG, TPO
20ivig4310.2TG, IFNG, IL6
21methimazole43 2 1212.1GSR, TG, TPO
22c-peptide4310.1TPO, GAD1, GAD2
233-Sulfinoalanine24 1211.1GAD2, GAD1, GSR
24selenium43 2411.1TPO, TG, GSR
25d penicillamine4310.1IFNG, GSR
26melphalan43 49 1212.0GSR, IL6, IFNG
27prednisolone43 28 1212.0GAD1, IL6, IFNG, TG
28hydrocortisone43 2 59 1213.0TPO, TG, IFNG, IL6
29gold439.9GAD1, TG, TPO
30ebselen439.8GSR, IFNG
31alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid439.8GRIA1, GSR
32aspartate439.7TPO, TG, GSR, GAD1, ENO1
33cyclosporin a43 28 5911.7TG, IFNG, IL6, GAD1, GAD2
34gaba439.7GAD2, GAD1, GRIA1, GSR
35genistein43 28 59 2 24 1214.7TPO, TG, IFNG, IL6, GSR
36creatinine439.5TPO, TG, IL6, GSR, GAD1, ENO1
37glutamine439.5TG, GRIA1, GAD1, ENO1
38acetylcholine43 49 28 24 1213.5TPO, TG, AMPH, GAD1, GAD2
39l-glutamic acid28 24 1211.4GSR, GRIA1, GRIN2B, GAD1, GAD2
40kainate43 2810.4GSR, GRIA1, GRIN2B, GAD1, GAD2
41alanine439.4TG, IL6, GSR, GAD1, GAD2
42nmda43 2810.4GSR, GRIA1, GRIN2B, GAD1, GAD2
43cysteine439.2TPO, TG, IFNG, GSR, GAD1, GAD2
44arginine439.2TPO, TG, IFNG, GSR, GRIA1, GAD1
45lactate439.2TG, IL6, GSR, ENO1
46nitric oxide43 24 1211.0TPO, IFNG, IL6, GRIA1, GRIN2B, GAD1
47dopamine43 28 24 1211.8PPP1R9B, GRIA1, GRIN2B, GAD1, GAD2
48tyrosine438.7SH2D1A, TPO, TG, IL6, GRIA1, GRIN2B
49calcium43 49 24 1211.4SH2D1A, TPO, AMPH, GRIA1, GRIN2B, GAD1
50glutamate437.4ENO1, PPP1R9B, TPO, TG, AMPH, GSR

GO Terms for genes affiliated with Limbic Encephalitis

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Cellular components related to Limbic Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:006120210.0GAD2, GAD1
2synaptic vesicleGO:00080219.1AMPH, GRIA1, GRIN2B
3extracellular spaceGO:00056158.8TPO, TG, LGI1, IFNG, IL6, ENO1
4cell junctionGO:00300548.7GAD2, GRIN2B, GRIA1, LGI1, AMPH

Biological processes related to Limbic Encephalitis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylation to succinateGO:000654010.2GAD2, GAD1
2neutrophil apoptotic processGO:000178110.2IFNG, IL6
3hormone biosynthetic processGO:004244610.2TG, TPO
4thyroid hormone generationGO:000659010.1TG, TPO
5neurotransmitter biosynthetic processGO:004213610.0GAD1, GAD2
6humoral immune responseGO:00069599.9IL6, IFNG, SH2D1A
7defense response to protozoanGO:00428329.9IL6, IFNG
8ionotropic glutamate receptor signaling pathwayGO:00352359.8GRIN2B, GRIA1
9response to drugGO:00424939.7IFNG, IL6, GAD1, GAD2
10nucleobase-containing small molecule interconversionGO:00159499.3GSR, AK5
11synaptic transmissionGO:00072689.0GAD2, GAD1, GRIN2B, GRIA1, AMPH

Molecular functions related to Limbic Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylase activityGO:000435110.0GAD2, GAD1
2extracellular-glutamate-gated ion channel activityGO:00052349.8GRIN2B, GRIA1
3glutamate bindingGO:00165959.7GAD2, GAD1
4protein bindingGO:00055155.8PPP1R9B, PNMA2, SH2D1A, AMPH, ADAM22, LGI1

Products for genes affiliated with Limbic Encephalitis

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Sources for Limbic Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet