MCID: LMB024
MIFTS: 53

Limbic Encephalitis malady

Rare diseases, Neuronal diseases categories

Summaries for Limbic Encephalitis

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Limbic encephalitis is a condition marked by the inflammation of the limbic system and other parts of the brain. the cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. the symptoms typically develop over a few weeks or months, but they may evolve over a few days. delayed diagnosis is common, but improvements are being made to assist in early detection. early diagnosis may improve the outcome of limbic encephalitis. last updated: 6/8/2009

MalaCards: Limbic Encephalitis is related to encephalitis and temporal lobe epilepsy. An important gene associated with Limbic Encephalitis is GAD1 (glutamate decarboxylase 1 (brain, 67kDa)), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Cytokines and Inflammatory Response. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and temporal lobe, and related mouse phenotypes are normal and endocrine/exocrine gland.

Wikipedia:66 Limbic encephalitis is a form of encephalitis, a disease characterised by inflammation of the brain.... more...

Aliases & Classifications for Limbic Encephalitis

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44NIH Rare Diseases, 46Novoseek, 50Orphanet, 63UMLS, 37MESH via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

limbic encephalitis 44 46 50 63


External Ids:

MESH via Orphanet37 D020363
SNOMED-CT via Orphanet60 230192003
UMLS via Orphanet64 C0338430

Related Diseases for Limbic Encephalitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Limbic Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis32.1GAD2, PNMA2, AMPH, LGI1
2temporal lobe epilepsy30.6GRIN2B, GAD2, GAD1, LGI1
3multiple sclerosis30.4IFNG, GSR, GAD1, IL6
4paraneoplastic syndromes30.3AMPH, IL6
5stiff-person syndrome30.3GAD1, GAD2, AMPH
6thyroiditis30.3TG, TPO, GAD2
7encephalomyelitis30.3GAD2, GAD1, IFNG
8alzheimer's disease30.2GRIN2B, GSR, GRIA1, IL6, GAD1
9systemic lupus erythematosus30.2IFNG, TPO, IL6, ENO1
10epilepsy syndrome30.0GRIA1, GSR, GRIN2B, LGI1, GAD2, GAD1
11non-herpetic acute limbic encephalitis10.7
12thymoma10.6
13teratoma10.6
14neuronitis10.6
15lung cancer10.6
16status epilepticus10.5
17relapsing polychondritis10.5
18adenocarcinoma10.4
19testicular cancer10.4
20limbic encephalitis with dpp6 antibodies10.4
21breast cancer10.3
22dementia10.3
23prostatitis10.3
24classic paraneoplastic limbic encephalitis10.3
25limbic encephalitis with lgi1 antibodies10.3
26limbic encephalitis with ncmags antibodies10.3
27posttransplant acute limbic encephalitis10.3
28limbic encephalitis with nmda receptor antibodies10.3
29viral encephalitis10.3
30anterograde amnesia10.3
31creutzfeldt-jakob disease10.3
32cerebellar ataxia10.3
33herpes simplex10.3
34leukemia10.3
35myasthenia gravis10.3
36prostate cancer10.3
37cerebellar degeneration10.3
38neurosyphilis10.3
39ataxia10.3
40myoclonus10.3
41limbic encephalitis with caspr2 antibodies10.3
42narcolepsy10.1
43subacute sclerosing panencephalitis10.1
44acute disseminated encephalomyelitis10.1
45gliomatosis cerebri10.1
46lambert-eaton myasthenic syndrome10.1
47cerebritis10.1
48primary biliary cirrhosis10.1
49acute myeloid leukemia10.1
50small cell carcinoma10.1

Graphical network of the top 20 diseases related to Limbic Encephalitis:



Diseases related to limbic encephalitis

Symptoms for Limbic Encephalitis

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Drugs & Therapeutics for Limbic Encephalitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Limbic Encephalitis

Drug clinical trials:

Search ClinicalTrials for Limbic Encephalitis

Search NIH Clinical Center for Limbic Encephalitis

Search CenterWatch for Limbic Encephalitis

Genetic Tests for Limbic Encephalitis

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Anatomical Context for Limbic Encephalitis

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34MalaCards
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MalaCards organs/tissues related to Limbic Encephalitis:

34
Brain, Lung, Temporal lobe, Prostate, Breast, Bone marrow, Colon, Bone, Eye, Spinal cord, Myeloid, Monocytes, B cells, Thyroid

Animal Models for Limbic Encephalitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Limbic Encephalitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.8GAD2, GAD1, GRIA1, GSR, IFNG, BRSK2
2MP:00053798.3TPO, TG, AMPH, IFNG, IL6, GAD1
3MP:00053786.9PPP1R9B, TPO, TG, ADAM22, LGI1, IFNG
4MP:00107686.9ADAM22, BRSK2, AMPH, TPO, ELAVL3, LGI1
5MP:00053766.8TG, TPO, SH2D1A, PPP1R9B, ELAVL3, IFNG
6MP:00053866.2ELAVL3, ADAM22, BRSK2, AMPH, PPP1R9B, LGI1
7MP:00036316.0GAD2, PPP1R9B, TG, AMPH, BRSK2, ADAM22

Publications for Limbic Encephalitis

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53PubMed
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Articles related to Limbic Encephalitis:

(show top 50)    (show all 354)
idTitleAuthorsYear
1
Autoimmune limbic encephalitis and anesthesia. (24104946)
2013
2
Limbic encephalitis: a clinical-radiological comparison between herpetic and autoimmune etiologies. (23941332)
2013
3
Correlative imaging with (18)F-FDG PET/CT and MRI in paraneoplastic limbic encephalitis. (23531769)
2013
4
Voltage-gated potassium channel antibody paraneoplastic limbic encephalitis associated with acute myeloid leukemia. (23898271)
2013
5
Limbic Encephalitis Associated With Elevated Antithyroid Antibodies. (23520363)
2013
6
Autoimmune limbic encephalitis presenting as relapsing psychosis. (23997078)
2013
7
Limbic encephalitis in a child: an atypical presentation. (24095576)
2013
8
A discrepancy between clinical course and magnetic resonance imaging in a case of non-herpetic acute limbic encephalitis. (23888211)
2013
9
The diagnosis and treatment of limbic encephalitis. (22713136)
2012
10
Surgical control of limbic encephalitis associated with LGI1 antibodies. (22940785)
2012
11
Two different 18F-FDG brain PET metabolic patterns in autoimmune limbic encephalitis. (22889795)
2012
12
Cord-blood hematopoietic stem cell transplantA confers an increased risk for human herpesvirus-6-associated acute limbic encephalitis: aA cohort analysis. (22564265)
2012
13
Proposition: limbic encephalitis may represent limbic status epilepticus. A review of clinical and EEG characteristics. (22459869)
2012
14
Limbic Encephalitis due to Pancreatic Cancer. (23147548)
2012
15
A boy with non-herpes simplex acute limbic encephalitis and antiglutamate receptor antibodies. (22084613)
2011
16
Continuous muscle activity, Morvan's syndrome and limbic encephalitis: ionic or non ionic disorders? (21842591)
2011
17
Autoimmune Limbic Encephalitis With GAD Antibodies. (23983853)
2011
18
Recognition of faciobrachial dystonic seizures allowing early intervention with and prevention of development of full-blown limbic encephalitis. (22319790)
2011
19
Steroid-responsive recurrent limbic encephalitis associated with small cell lung cancer and neuropil antibodies. (21748934)
2011
20
Paraneoplastic syndrome of inappropriate antidiuretic hormone mimicking limbic encephalitis. (22159058)
2011
21
An effective immunotherapy regimen for VGKC antibody-positive limbic encephalitis. (20660916)
2010
22
Non-paraneoplastic limbic encephalitis associated with NMDAR and VGKC antibodies. (20667865)
2010
23
Limbic encephalitis associated with systemic lupus erythematosus. (19850655)
2009
24
Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis. (19716567)
2009
25
Voltage-gated potassium channel-associated limbic encephalitis in the West of Scotland: case reports and literature review. (20034278)
2009
26
An autopsy case with non-herpetic acute limbic encephalitis (NHALE). (18282167)
2008
27
Paraneoplastic limbic encephalitis as a cause of new onset of seizures in a patient with non-small cell lung carcinoma: a case report. (18700972)
2008
28
Acute limbic encephalitis: diagnostic and management implications. (18197513)
2008
29
Limbic encephalitis as presentation of a SAP deficiency. (17620557)
2007
30
Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. (17620548)
2007
31
Complex partial status epilepticus in paraneoplastic limbic encephalitis. (17844948)
2007
32
Limbic encephalitis--an uncommon presentation of systemic malignancy. (18173029)
2007
33
Limbic encephalitis: extension of the diagnostic armamentarium. (17018560)
2007
34
Limbic encephalitis: another example of molecular mimicry? (17389799)
2007
35
Anti-Hu-associated paraneoplastic limbic encephalitis presenting as rapidly progressive non-convulsive status epilepticus. (16631204)
2006
36
Reversible paraneoplastic limbic encephalitis caused by a benign ovarian teratoma: report of a case and review of literatures. (16944314)
2006
37
Electroconvulsive therapy in a pediatric patient with malignant catatonia and paraneoplastic limbic encephalitis. (17143159)
2006
38
Paraneoplastic limbic encephalitis. (15708228)
2005
39
Neurosyphilis and paraneoplastic limbic encephalitis: important differential diagnoses. (15789128)
2005
40
Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. (15888538)
2005
41
A pre-senile case of limbic encephalitis and cerebellar degeneration, with subacute onset of progressive dementia. (15673963)
2004
42
Non-herpetic acute limbic encephalitis: a new subgroup of limbic encephalitis? (15168784)
2004
43
Resolution of limbic encephalitis with detection and treatment of lung cancer: clinical-radiological correlation. (12499067)
2003
44
Asessment of paraneoplastic limbic encephalitis in testicular cancer. (12846502)
2003
45
Paraneoplastic limbic encephalitis masquerading as chronic behavioural disturbance in an adolescent girl. (12801123)
2003
46
Hypermetabolism of the medial temporal lobe in limbic encephalitis on (18)FDG-PET scan: a case report. (11306867)
2001
47
Varicella-zoster virus limbic encephalitis in an immunocompromised patient. (11728054)
2001
48
Paraneoplastic limbic encephalitis should not be overlooked as a possible cause of delirium in cancer patients. (11025799)
2000
49
Limbic encephalitis. A rare presentation of the small-cell lung carcinoma. (2553530)
1989
50
Small-cell lung cancer and limbic encephalitis. (6283978)
1982

Variations for Limbic Encephalitis

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Expression for genes affiliated with Limbic Encephalitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Limbic Encephalitis

Search GEO for disease gene expression data for Limbic Encephalitis.

Pathways for genes affiliated with Limbic Encephalitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 31KEGG, 5Cell Signaling Technology, 13EMD Millipore, 55R&D Systems, 54QIAGEN
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Pathways related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TPO, TG
210.0IFNG, IL6
310.0IFNG, IL6
4
Show member pathways
catecholamine biosynthesis39
10.0GAD1, GAD2
510.0GAD1, GAD2
6
Show member pathways
10.0GAD1, GAD2
7
Show member pathways
10.0GAD2, GAD1
8
Show member pathways
10.0GAD2, GAD1
9
Show member pathways
Type III interferon signaling39
9.8TPO, IL6, IFNG
109.8ENO1, IFNG, IL6
11
Show member pathways
9.7GSR, TG, TPO
12
Show member pathways
thioredoxin pathway39
9.7GSR, IFNG, IL6
139.7ENO1, GAD2, BRSK2
14
Show member pathways
9.3GRIA1, GRIN2B, GAD1, GAD2
15
Show member pathways
9.3GAD2, GRIA1, GRIN2B, GAD1
16
Show member pathways
9.3GAD2, GRIA1, GRIN2B, GAD1
17
Show member pathways
9.1IFNG, GAD2, TG, TPO, IL6, GAD1
18
Show member pathways
8.6GRIN2B, PPP1R9B, TPO, IFNG, IL6
198.2BRSK2, GRIA1, GRIN2B, GAD1, GAD2, PPP1R9B

Compounds for genes affiliated with Limbic Encephalitis

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46Novoseek, 25HMDB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 12DrugBank, 52PharmGKB
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Compounds related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1iodotyrosine46 2511.5TG, TPO
2diiodotyrosine4610.4TG, TPO
3perchlorate4610.4TPO, TG
4Cysteic acid2510.4GAD2, GAD1
518f fluorodeoxyglucose4610.3TG, GAD1
6cysteine sulfinic acid4610.3GAD2, GAD1
7bucillamine4610.3IFNG, IL6
8hypotaurine62 46 2512.3GAD1, GAD2
9gamma globulin4610.3TG, IFNG
10sodium iodide4610.3TPO, TG
11guaiacol46 2511.2TPO, GSR
12vesnarinone4610.2IFNG, IL6
13atpo30 4611.2TPO, GRIA1
14taurine chloramine4610.2IFNG, IL6
153-amino-1,2,4-triazole4610.2GSR, TG
16gliadin4610.2GAD2, TG, TPO
17propylthiouracil46 3 1212.2TPO, TG
18125i4610.2TPO, TG, GAD2
19chromium4610.2GSR, TG, TPO
20ivig4610.2TG, IFNG, IL6
21methimazole46 3 1212.1GSR, TG, TPO
22c-peptide4610.1TPO, GAD1, GAD2
233-Sulfinoalanine25 1211.1GAD2, GAD1, GSR
24selenium46 2511.1TPO, TG, GSR
25d penicillamine4610.1IFNG, GSR
26melphalan46 52 1212.0GSR, IL6, IFNG
27prednisolone46 30 1212.0GAD1, IL6, IFNG, TG
28hydrocortisone46 3 62 1213.0TPO, TG, IFNG, IL6
29gold469.9GAD1, TG, TPO
30ebselen469.8GSR, IFNG
31alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid469.8GRIA1, GSR
32aspartate469.7TPO, TG, GSR, GAD1, ENO1
33cyclosporin a46 30 6211.7TG, IFNG, IL6, GAD1, GAD2
34gaba469.7GAD2, GAD1, GRIA1, GSR
35genistein46 30 62 3 25 1214.7TPO, TG, IFNG, IL6, GSR
36creatinine469.5TPO, TG, IL6, GSR, GAD1, ENO1
37glutamine469.5TG, GRIA1, GAD1, ENO1
38acetylcholine46 52 30 25 1213.5TPO, TG, AMPH, GAD1, GAD2
39l-glutamic acid30 25 1211.4GSR, GRIA1, GRIN2B, GAD1, GAD2
40kainate46 3010.4GSR, GRIA1, GRIN2B, GAD1, GAD2
41alanine469.4TG, IL6, GSR, GAD1, GAD2
42nmda46 3010.4GSR, GRIA1, GRIN2B, GAD1, GAD2
43cysteine469.2TPO, TG, IFNG, GSR, GAD1, GAD2
44arginine469.2TPO, TG, IFNG, GSR, GRIA1, GAD1
45lactate469.2TG, IL6, GSR, ENO1
46nitric oxide46 25 1211.0TPO, IFNG, IL6, GRIA1, GRIN2B, GAD1
47dopamine46 30 25 1211.8PPP1R9B, GRIA1, GRIN2B, GAD1, GAD2
48tyrosine468.7SH2D1A, TPO, TG, IL6, GRIA1, GRIN2B
49calcium46 52 25 1211.4SH2D1A, TPO, AMPH, GRIA1, GRIN2B, GAD1
50glutamate467.4ENO1, PPP1R9B, TPO, TG, AMPH, GSR

GO Terms for genes affiliated with Limbic Encephalitis

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17Gene Ontology
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Cellular components related to Limbic Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:06120210.0GAD2, GAD1
2synaptic vesicleGO:0080219.1AMPH, GRIA1, GRIN2B
3extracellular spaceGO:0056158.8TPO, TG, LGI1, IFNG, IL6, ENO1
4cell junctionGO:0300548.7GAD2, GRIN2B, GRIA1, LGI1, AMPH

Biological processes related to Limbic Encephalitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylation to succinateGO:00654010.2GAD2, GAD1
2neutrophil apoptotic processGO:00178110.2IFNG, IL6
3hormone biosynthetic processGO:04244610.2TG, TPO
4thyroid hormone generationGO:00659010.1TG, TPO
5neurotransmitter biosynthetic processGO:04213610.0GAD1, GAD2
6humoral immune responseGO:0069599.9IL6, IFNG, SH2D1A
7defense response to protozoanGO:0428329.9IL6, IFNG
8ionotropic glutamate receptor signaling pathwayGO:0352359.8GRIN2B, GRIA1
9response to drugGO:0424939.7IFNG, IL6, GAD1, GAD2
10nucleobase-containing small molecule interconversionGO:0159499.3GSR, AK5
11synaptic transmissionGO:0072689.0GAD2, GAD1, GRIN2B, GRIA1, AMPH

Molecular functions related to Limbic Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylase activityGO:00435110.0GAD2, GAD1
2extracellular-glutamate-gated ion channel activityGO:0052349.8GRIN2B, GRIA1
3glutamate bindingGO:0165959.7GAD2, GAD1
4protein bindingGO:0055155.8PPP1R9B, PNMA2, SH2D1A, AMPH, ADAM22, LGI1

Products for genes affiliated with Limbic Encephalitis

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  • Antibodies
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Sources for Limbic Encephalitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet