MCID: LMB024
MIFTS: 35

Limbic Encephalitis malady

Category: Rare diseases

Aliases & Classifications for Limbic Encephalitis

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Aliases & Descriptions for Limbic Encephalitis:

Name: Limbic Encephalitis 46 48 66

Classifications:



Summaries for Limbic Encephalitis

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NIH Rare Diseases:46 Limbic encephalitis represents a group of autoimmune conditions characterized by inflammation of the limbic system and other parts of the brain. the cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. the symptoms typically develop over a few weeks or months, but they may evolve over a few days. limbic encephalitis is often associated with an underlying neoplasm (paraneoplastic limbic encephalitis); however some cases never have a neoplasm identified (non-paraneoplastic limbic encephalitis). delayed diagnosis is common, but improvements are being made to assist in early detection. various tests including imaging studies (mri, pet) laboratory tests (csf analysis), and tests that measure the electrical activity of the brain (eeg) may be utilized to confirm a diagnosis. treatment includes removal of the neoplasm (if identified) and immunotherapy. last updated: 4/26/2016

MalaCards based summary: Limbic Encephalitis is related to epilepsy and non-herpetic acute limbic encephalitis. An important gene associated with Limbic Encephalitis is GAD1 (Glutamate Decarboxylase 1), and among its related pathways are LGI-ADAM interactions and Hypothetical Network for Drug Addiction. Affiliated tissues include brain, testes and lung, and related mouse phenotypes are behavior/neurological and nervous system.

Wikipedia:69 Limbic encephalitis is a form of encephalitis, a disease characterised by inflammation of the brain.... more...

Related Diseases for Limbic Encephalitis

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Diseases related to Limbic Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1epilepsy30.5GRIA1, GRIN2B, LGI1
2non-herpetic acute limbic encephalitis12.2
3posttransplant acute limbic encephalitis12.2
4limbic encephalitis with dpp6 antibodies12.2
5classic paraneoplastic limbic encephalitis12.1
6limbic encephalitis with lgi1 antibodies12.1
7limbic encephalitis with ncmags antibodies12.1
8limbic encephalitis with nmda receptor antibodies12.1
9limbic encephalitis with caspr2 antibodies12.1
10encephalitis11.1
11neuropathy, hereditary sensory and autonomic, type ii11.1
12neuronitis10.4
13paraomphalocele10.4AMPH, ELAVL3
14teratoma10.3
15lung cancer10.3
16thymoma10.3
17lymphoma10.2
18status epilepticus10.2
19relapsing polychondritis10.2
20glioma10.2
21temporal lobe epilepsy10.2
22hodgkin lymphoma10.1
23dementia10.1
24testicular lymphoma10.1GAD1, GRIA1, LGI1
25acrocephalopolysyndactyly type iii10.1GAD1, GAD2
26adenocarcinoma10.1
27testicular cancer10.1
28cerebellar degeneration10.1
29dyskinetic cerebral palsy10.1GAD1, GAD2
30breast cancer10.0
31prostatitis10.0
32paraneoplastic cerebellar degeneration10.0
33encephalopathy10.0
34paraneoplastic syndromes10.0
35neonatal myasthenia gravis10.0GAD1, GAD2
36prostate cancer9.9
37renal cell carcinoma9.9
38cerebellar ataxia9.9
39creutzfeldt-jakob disease9.9
40stiff-person syndrome9.9
41leukemia9.9
42myasthenia gravis9.9
43ovarian cancer9.9
44cerebritis9.9
45anterograde amnesia9.9
46herpes simplex9.9
47syndrome of inappropriate antidiuretic hormone9.9
48neurosyphilis9.9
49ataxia9.9
50myoclonus9.9

Graphical network of the top 20 diseases related to Limbic Encephalitis:



Diseases related to limbic encephalitis

Symptoms for Limbic Encephalitis

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Drugs & Therapeutics for Limbic Encephalitis

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Drugs for Limbic Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Tacrolimus1058104987-11-3445643, 439492
Synonyms:
(-)-FK 506
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
104987-11-3
109581-93-3 (Hydrate)
15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,
3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
AC-1182
AC1L1K7H
AC1L97GB
AC1L9IBU
AKOS005145901
Advagraf
Ambap104987-11-3
Ambap5429
Anhydrous tacrolimus
BCBcMAP01_000194
BRD-K35452788-001-02-1
BSPBio-001279
BSPBio_001279
Bio-0921
Bio2_000470
Bio2_000950
C01375
C44H69NO10
CCRIS 7124
CHEBI:100924
CHEBI:61049
CHEMBL1200738
CID11158639
CID11556866
CID439492
CID445643
CID5372
CID5472317
CID6426916
CID6436007
CID6473866
CID6536850
CID6610362
CID6912836
CID9832283
CID9853905
CID9918805
CID9940643
CID9963169
CPD-10016
CPD000466356
D08556
DB00864
DivK1c_001040
FK 506
FK-506
FK5
FK506
FR 900506
FR-900506
 
FR900506
FT-0082660
Fk-506
Fujimycin
Graceptor
HMS1362O21
HMS1792O21
HMS1990O21
HMS2051C18
HMS2093M19
HMS503O21
IDI1_001040
IDI1_002225
K506
KBio1_001040
KBio2_000619
KBio2_003187
KBio2_005755
KBio3_001097
KBio3_001098
KBioGR_000619
KBioSS_000619
L 679934
L-679934
LCP-Tacro
LMPK04000003
LS-64247
MLS000759471
MLS001424054
Modigraf
MolPort-003-666-518
NCGC00163470-01
NCGC00163470-02
NCGC00163470-03
NCGC00163470-04
NCGC00179232-01
NChemBio.2007.16-comp1
NINDS_001040
NSC717865
Prograf
Prograf (TN)
Protopic
Protopy
S5003_Selleck
SAM001246677
SMR000466356
Tacarolimus
Tacrolimus (INN)
Tacrolimus (Prograf?)
Tacrolimus (anhydrous)
Tacrolimus anhydrous
Tacrolimus hydrate
Tacrolimus, anhydrous
Tsukubaenolide
UNII-Y5L2157C4J
nchembio.2007.23-comp2
tacrolimus
tacrolimus hydrate
2
Prednisone131853-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
 
Juvason
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone

Interventional clinical trials:

idNameStatusNCT IDPhase
1IVIG Treatment for Refractory Immune-Related Adult EpilepsyTerminatedNCT01545518Phase 2
2Immunotherapy of the Paraneoplastic SyndromesCompletedNCT00378326
3Antibodies Causing Epilepsy Syndromes: The ACES Study.RecruitingNCT02802475
4Interest Balance Auto-immune Population in Patients With Focal Epilepsy of Unknown Cause, Not Structural, Not Genetics, Newly DiagnosedRecruitingNCT02885207

Search NIH Clinical Center for Limbic Encephalitis

Genetic Tests for Limbic Encephalitis

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Anatomical Context for Limbic Encephalitis

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MalaCards organs/tissues related to Limbic Encephalitis:

34
Brain, Testes, Lung, Temporal lobe, Bone marrow, Prostate, Breast

Animal Models for Limbic Encephalitis or affiliated genes

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MGI Mouse Phenotypes related to Limbic Encephalitis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053866.6ADAM22, AMPH, BRSK2, ELAVL3, GAD1, GAD2
2MP:00036316.3ADAM22, AMPH, BRSK2, ELAVL3, GAD1, GAD2

Publications for Limbic Encephalitis

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Articles related to Limbic Encephalitis:

(show top 50)    (show all 451)
idTitleAuthorsYear
1
Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis. (27429684)
2016
2
Suspected antibody negative autoimmune limbic encephalitis: outcome of immunotherapy. (26940288)
2016
3
Limbic Encephalitis Diagnosed With 18F-FDG PET/CT. (26571448)
2015
4
Long latency between GAD-antibody detection and development of limbic encephalitis - a case report. (26420440)
2015
5
Melancholia Associated With Severe Cognitive Disorders as the Expression of Late-Onset Postpartum Anti-N-Methyl-d-Aspartic Acid Receptor Limbic Encephalitis. (25923872)
2015
6
Human herpesvirus-6 acute limbic encephalitis after unrelated umbilical cord blood transplantation successfully treated with ganciclovir. (26146808)
2015
7
Limbic encephalitis and Lambert Eaton myasthenic syndrome - An immunological profile of a new syndrome. (24269050)
2014
8
Limbic encephalitis associated with anti-voltage-gated potassium channel complex antibodies as a cause of adult-onset mesial temporal lobe epilepsy. (24930877)
2014
9
Autoimmune limbic encephalitis and anesthesia. (24104946)
2013
10
Limbic encephalitis: a clinical-radiological comparison between herpetic and autoimmune etiologies. (23941332)
2013
11
Voltage-gated potassium channel antibody paraneoplastic limbic encephalitis associated with acute myeloid leukemia. (23898271)
2013
12
Autoimmune limbic encephalitis presenting as relapsing psychosis. (23997078)
2013
13
Improvement of paraneoplastic limbic encephalitis after systemic treatment with rituximab in a patient with B-cell chronic lymphocytic leukemia. (23984126)
2013
14
Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors. (24227725)
2013
15
Surgical control of limbic encephalitis associated with LGI1 antibodies. (22940785)
2012
16
Proposition: limbic encephalitis may represent limbic status epilepticus. A review of clinical and EEG characteristics. (22459869)
2012
17
Limbic Encephalitis due to Pancreatic Cancer. (23147548)
2012
18
LGI-1-positive limbic encephalitis: a clinicopathological study. (22648478)
2012
19
Continuous muscle activity, Morvan's syndrome and limbic encephalitis: ionic or non ionic disorders? (21842591)
2011
20
Recognition of faciobrachial dystonic seizures allowing early intervention with and prevention of development of full-blown limbic encephalitis. (22319790)
2011
21
Paraneoplastic syndrome of inappropriate antidiuretic hormone mimicking limbic encephalitis. (22159058)
2011
22
Whipple limbic encephalitis. (22084133)
2011
23
Spontaneously resolving seronegative autoimmune limbic encephalitis. (21677575)
2011
24
Neuroimmunology: Antibodies target LGI1 rather than potassium channels in limbic encephalitis. (20836192)
2010
25
Voltage-gated potassium channel-associated limbic encephalitis in the West of Scotland: case reports and literature review. (20034278)
2009
26
A limbic encephalitis MR imaging in a patient with Behcet disease and relapsing polychondritis. (19386730)
2009
27
Image of the month. FDG-PET in paraneoplastic limbic encephalitis. (19107479)
2009
28
Paraneoplastic limbic encephalitis. (19377018)
2009
29
An autopsy case with non-herpetic acute limbic encephalitis (NHALE). (18282167)
2008
30
Acute limbic encephalitis: diagnostic and management implications. (18197513)
2008
31
Temporal lobectomy for refractory status epilepticus in a case of limbic encephalitis. (18826364)
2008
32
Limbic encephalitis: extension of the diagnostic armamentarium. (17018560)
2007
33
Limbic encephalitis: another example of molecular mimicry? (17389799)
2007
34
Anti-Hu-associated paraneoplastic limbic encephalitis presenting as rapidly progressive non-convulsive status epilepticus. (16631204)
2006
35
Reversible paraneoplastic limbic encephalitis caused by a benign ovarian teratoma: report of a case and review of literatures. (16944314)
2006
36
Neurosyphilis and paraneoplastic limbic encephalitis: important differential diagnoses. (15789128)
2005
37
Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. (15888538)
2005
38
Paraneoplastic limbic encephalitis. (15855786)
2005
39
BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis. (16165222)
2005
40
A pre-senile case of limbic encephalitis and cerebellar degeneration, with subacute onset of progressive dementia. (15673963)
2004
41
Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibody. (15079019)
2004
42
Resolution of limbic encephalitis with detection and treatment of lung cancer: clinical-radiological correlation. (12499067)
2003
43
Hypermetabolism of the medial temporal lobe in limbic encephalitis on (18)FDG-PET scan: a case report. (11306867)
2001
44
Human herpesvirus 6 limbic encephalitis after stem cell transplantation. (11706967)
2001
45
Memory rehabilitation of an amnesic patient following limbic encephalitis and a role of family members: a case report. (11358032)
2000
46
Paraneoplastic limbic encephalitis with immature ovarian teratoma--a case report. (9525839)
1998
47
Limbic encephalitis secondary to malignant thymoma. (8037541)
1994
48
Magnetic resonance imaging of limbic encephalitis. (8384926)
1993
49
Evolution of brain MRI abnormalities in limbic encephalitis. (2166250)
1990
50
Limbic encephalitis: two cases. (3198743)
1988

Variations for Limbic Encephalitis

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Expression for genes affiliated with Limbic Encephalitis

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Search GEO for disease gene expression data for Limbic Encephalitis.

Pathways for genes affiliated with Limbic Encephalitis

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GO Terms for genes affiliated with Limbic Encephalitis

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Cellular components related to Limbic Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendritic spine membraneGO:003259110.0GRIA1, PPP1R9B
2clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:00612029.8GAD1, GAD2
3cell junctionGO:00300548.4AMPH, GAD2, GRIA1, GRIN2B, LGI1

Biological processes related to Limbic Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylation to succinateGO:000654010.4GAD1, GAD2
2ionotropic glutamate receptor signaling pathwayGO:003523510.2GRIA1, GRIN2B
3neurotransmitter biosynthetic processGO:004213610.1GAD1, GAD2
4nucleobase-containing small molecule interconversionGO:00159499.9AK5, GSR
5chemical synaptic transmissionGO:00072688.4AMPH, GAD1, GAD2, GRIA1, GRIN2B

Molecular functions related to Limbic Encephalitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular-glutamate-gated ion channel activityGO:000523410.1GRIA1, GRIN2B
2glutamate decarboxylase activityGO:000435110.0GAD1, GAD2
3glutamate bindingGO:00165959.8GAD1, GAD2

Sources for Limbic Encephalitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet