LWNH
MCID: LNR007
MIFTS: 23

Linear and Whorled Nevoid Hypermelanosis (LWNH) malady

Rare diseases, Skin diseases categories

Summaries for Linear and Whorled Nevoid Hypermelanosis

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Sources:
44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Linear and whorled nevoid hypermelanosis is a skin condition characterized by swirling streaks of hyperpigmented (darkened) skin. the hyperpigmentation follows the lines of blashko. the hyperpigmentation often occurs alone, but additional symptoms have been described in individual cases. its occurrence is nearly always sporadic. the cause of linear and whorled nevoid hypermelanosis is not known. last updated: 3/18/2013

MalaCards: Linear and Whorled Nevoid Hypermelanosis, also known as nevoid hypermelanosis, linear and whorled, is related to ichthyosis vulgaris and cerebritis. An important gene associated with Linear and Whorled Nevoid Hypermelanosis is IKBKG (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma). Affiliated tissues include skin.

Wikipedia:66 Linear and whorled nevoid hypermelanosis (also known as \"Linear nevoid hyperpigmentation,\"... more...

Description from OMIM:48 614323

Aliases & Classifications for Linear and Whorled Nevoid Hypermelanosis

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Sources:
44NIH Rare Diseases, 50Orphanet, 48OMIM, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases
Orphanet: 50 
Rare skin diseases


Aliases & Descriptions:

linear and whorled nevoid hypermelanosis 44 50 48
nevoid hypermelanosis, linear and whorled 44
reticulate hyperpigmentation of iijima 44
linear and whorled hypermelanosis 44
zosteriform hyperpigmentation 44
zosteriform lentiginous nevus 44
zebra-like hyperpigmentation 44
lwnh 44


External Ids:

OMIM48 614323
ICD10 via Orphanet27 L81.4
SNOMED-CT via Orphanet60 403803002
UMLS via Orphanet64 C1304501

Related Diseases for Linear and Whorled Nevoid Hypermelanosis

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18GeneCards, 19GeneDecks
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Diseases related to Linear and Whorled Nevoid Hypermelanosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1ichthyosis vulgaris10.5
2cerebritis10.5
3inflammatory linear verrucous epidermal nevus10.5
4epidermal nevus10.5
5aneurysm10.5
6cerebral aneurysms10.5

Graphical network of diseases related to Linear and Whorled Nevoid Hypermelanosis:



Diseases related to linear and whorled nevoid hypermelanosis

Symptoms for Linear and Whorled Nevoid Hypermelanosis

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48OMIM
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Symptoms by clinical synopsis from OMIM:

614323

Clinical features from OMIM:

614323

Drugs & Therapeutics for Linear and Whorled Nevoid Hypermelanosis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Linear and Whorled Nevoid Hypermelanosis

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Anatomical Context for Linear and Whorled Nevoid Hypermelanosis

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34MalaCards
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MalaCards organs/tissues related to Linear and Whorled Nevoid Hypermelanosis:

34
Skin

Animal Models for Linear and Whorled Nevoid Hypermelanosis or affiliated genes

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Publications for Linear and Whorled Nevoid Hypermelanosis

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53PubMed
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Articles related to Linear and Whorled Nevoid Hypermelanosis:

idTitleAuthorsYear
1
Linear and whorled nevoid hypermelanosis complicated with inflammatory linear verrucous epidermal nevus and ichthyosis vulgaris. (17973817)
2007
2
Linear and whorled nevoid hypermelanosis with bilateral giant cerebral aneurysms. (12239729)
2002

Variations for Linear and Whorled Nevoid Hypermelanosis

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Expression for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

Search GEO for disease gene expression data for Linear and Whorled Nevoid Hypermelanosis.

Pathways for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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Compounds for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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GO Terms for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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Products for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Linear and Whorled Nevoid Hypermelanosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet