LWNH
MCID: LNR007
MIFTS: 24

Linear and Whorled Nevoid Hypermelanosis (LWNH) malady

Rare diseases, Skin diseases categories

Summaries for Linear and Whorled Nevoid Hypermelanosis

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OMIM:46 Linear and whorled hypermelanosis (LWNH) is a benign skin condition characterized by onset in infancy of hyperpigmented...614323 more...

MalaCards based summary: Linear and Whorled Nevoid Hypermelanosis, also known as LWNH, is related to ichthyosis vulgaris and cerebritis, and has symptoms including autosomal dominant inheritance, eosinophilia and infantile onset. An important gene associated with Linear and Whorled Nevoid Hypermelanosis is IKBKG (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma). Affiliated tissues include skin.

NIH Rare Diseases:42 Linear and whorled nevoid hypermelanosis is a skin condition characterized by swirling streaks of hyperpigmented (darkened) skin. the hyperpigmentation follows the lines of blashko. the hyperpigmentation often occurs alone, but additional symptoms have been described in individual cases. its occurrence is nearly always sporadic. the cause of linear and whorled nevoid hypermelanosis is not known. last updated: 3/18/2013

Wikipedia:64 Linear and whorled nevoid hypermelanosis (also known as \"Linear nevoid hyperpigmentation,\"... more...

Aliases & Classifications for Linear and Whorled Nevoid Hypermelanosis

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Sources:
42NIH Rare Diseases, 48Orphanet, 46OMIM, 61UMLS, 27ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Linear and Whorled Nevoid Hypermelanosis, Aliases & Descriptions:

Name: Linear and Whorled Nevoid Hypermelanosis 42 48 46
Lwnh 42 61
Nevoid Hypermelanosis, Linear and Whorled 42
Reticulate Hyperpigmentation of Iijima 42
 
Linear and Whorled Hypermelanosis 42
Zosteriform Lentiginous Nevus 42
Zosteriform Hyperpigmentation 42
Zebra-Like Hyperpigmentation 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases
Orphanet: 48 
Rare skin diseases


External Ids:

OMIM46 614323
ICD10 via Orphanet27 L81.4
UMLS via Orphanet62 C1304501

Related Diseases for Linear and Whorled Nevoid Hypermelanosis

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Diseases related to Linear and Whorled Nevoid Hypermelanosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1ichthyosis vulgaris10.6
2cerebritis10.6
3inflammatory linear verrucous epidermal nevus10.6
4epidermal nevus10.6
5aneurysm10.6
6cerebral aneurysms10.6

Graphical network of diseases related to Linear and Whorled Nevoid Hypermelanosis:



Diseases related to linear and whorled nevoid hypermelanosis

Symptoms for Linear and Whorled Nevoid Hypermelanosis

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Symptoms by clinical synopsis from OMIM:

614323

Clinical features from OMIM:

614323

HPO human phenotypes related to Linear and Whorled Nevoid Hypermelanosis:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 eosinophilia HP:0001880
3 infantile onset HP:0003593
4 hyperpigmented streaks HP:0007572

Drugs & Therapeutics for Linear and Whorled Nevoid Hypermelanosis

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Drug clinical trials:

Search ClinicalTrials for Linear and Whorled Nevoid Hypermelanosis

Search NIH Clinical Center for Linear and Whorled Nevoid Hypermelanosis

Genetic Tests for Linear and Whorled Nevoid Hypermelanosis

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Anatomical Context for Linear and Whorled Nevoid Hypermelanosis

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MalaCards organs/tissues related to Linear and Whorled Nevoid Hypermelanosis:

32
Skin

Animal Models for Linear and Whorled Nevoid Hypermelanosis or affiliated genes

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Publications for Linear and Whorled Nevoid Hypermelanosis

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Articles related to Linear and Whorled Nevoid Hypermelanosis:

idTitleAuthorsYear
1
Linear and whorled nevoid hypermelanosis complicated with inflammatory linear verrucous epidermal nevus and ichthyosis vulgaris. (17973817)
2007
2
Linear and whorled nevoid hypermelanosis with bilateral giant cerebral aneurysms. (12239729)
2002

Variations for Linear and Whorled Nevoid Hypermelanosis

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Expression for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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Expression patterns in normal tissues for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

Search GEO for disease gene expression data for Linear and Whorled Nevoid Hypermelanosis.

Pathways for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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Compounds for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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GO Terms for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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Products for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Linear and Whorled Nevoid Hypermelanosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet