LWNH
MCID: LNR007
MIFTS: 23

Linear and Whorled Nevoid Hypermelanosis (LWNH) malady

Rare diseases, Skin diseases categories
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Summaries for Linear and Whorled Nevoid Hypermelanosis

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Sources:
43NIH Rare Diseases, 65Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Linear and whorled nevoid hypermelanosis is a skin condition characterized by swirling streaks of hyperpigmented (darkened) skin. the hyperpigmentation follows the lines of blashko. the hyperpigmentation often occurs alone, but additional symptoms have been described in individual cases. its occurrence is nearly always sporadic. the cause of linear and whorled nevoid hypermelanosis is not known. last updated: 3/18/2013

MalaCards: Linear and Whorled Nevoid Hypermelanosis, also known as nevoid hypermelanosis, linear and whorled, is related to ichthyosis vulgaris and cerebritis. An important gene associated with Linear and Whorled Nevoid Hypermelanosis is IKBKG (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma). Affiliated tissues include skin.

Wikipedia:65 Linear and whorled nevoid hypermelanosis (also known as \"Linear nevoid hyperpigmentation,\"... more...

Description from OMIM:47 614323

Aliases & Classifications for Linear and Whorled Nevoid Hypermelanosis

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Sources:
43NIH Rare Diseases, 49Orphanet, 47OMIM, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases
Orphanet: 49 
Rare skin diseases


Aliases & Descriptions:

linear and whorled nevoid hypermelanosis 43 49 47
nevoid hypermelanosis, linear and whorled 43
reticulate hyperpigmentation of iijima 43
linear and whorled hypermelanosis 43
zosteriform hyperpigmentation 43
zosteriform lentiginous nevus 43
zebra-like hyperpigmentation 43
lwnh 43


External Ids:

OMIM47 614323
ICD10 via Orphanet26 L81.4
SNOMED-CT via Orphanet59 403803002
UMLS via Orphanet63 C1304501

Related Diseases for Linear and Whorled Nevoid Hypermelanosis

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17GeneCards, 18GeneDecks
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Diseases related to Linear and Whorled Nevoid Hypermelanosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1ichthyosis vulgaris10.5
2cerebritis10.5
3inflammatory linear verrucous epidermal nevus10.5
4epidermal nevus10.5
5aneurysm10.5
6cerebral aneurysms10.5

Graphical network of diseases related to Linear and Whorled Nevoid Hypermelanosis:



Diseases related to linear and whorled nevoid hypermelanosis

Symptoms for Linear and Whorled Nevoid Hypermelanosis

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47OMIM
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Symptoms by clinical synopsis from OMIM:

614323

Clinical features from OMIM:

614323

Drugs & Therapeutics for Linear and Whorled Nevoid Hypermelanosis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Linear and Whorled Nevoid Hypermelanosis

Genetic Tests for Linear and Whorled Nevoid Hypermelanosis

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Anatomical Context for Linear and Whorled Nevoid Hypermelanosis

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33MalaCards
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MalaCards organs/tissues related to Linear and Whorled Nevoid Hypermelanosis:

33
Skin

Animal Models for Linear and Whorled Nevoid Hypermelanosis or affiliated genes

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Publications for Linear and Whorled Nevoid Hypermelanosis

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52PubMed
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Articles related to Linear and Whorled Nevoid Hypermelanosis:

idTitleAuthorsYear
1
Linear and whorled nevoid hypermelanosis complicated with inflammatory linear verrucous epidermal nevus and ichthyosis vulgaris. (17973817)
2007
2
Linear and whorled nevoid hypermelanosis with bilateral giant cerebral aneurysms. (12239729)
2002

Variations for Linear and Whorled Nevoid Hypermelanosis

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Expression for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

Search GEO for disease gene expression data for Linear and Whorled Nevoid Hypermelanosis.

Pathways for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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Compounds for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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GO Terms for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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Products for genes affiliated with Linear and Whorled Nevoid Hypermelanosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Linear and Whorled Nevoid Hypermelanosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet