MCID: LNT001
MIFTS: 34

Linitis Plastica malady

Gastrointestinal category

Summaries for Linitis Plastica

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Linitis plastica, also known as Brinton\'s disease or leather bottle stomach, is a morphological variant... more...

MalaCards: Linitis Plastica, also known as leather-bottle stomach, is related to signet ring cell adenocarcinoma and stomach cancer. An important gene associated with Linitis Plastica is PRSS2 (protease, serine, 2 (trypsin 2)), and among its related pathways is Adhesion. The compounds slex and b 723 have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and small intestine.

Aliases & Classifications for Linitis Plastica

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

linitis plastica 8 61
leather-bottle stomach 8


External Ids:

Disease Ontology8 DOID:4023
MeSH35 D008039
SNOMED-CT57 307594007, 37995004
NCIt40 C3190

Related Diseases for Linitis Plastica

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to linitis plastica

Clinical Features for Linitis Plastica

Drugs & Therapeutics for Linitis Plastica

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Linitis Plastica

Anatomical Context for Linitis Plastica

Sources:
33MalaCards
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MalaCards organs/tissues related to Linitis Plastica:

33
Skin, Lymph node, Small intestine, Colon, Breast, Prostate, Appendix

Animal Models for Linitis Plastica or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Linitis Plastica

Sources:
51PubMed
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Articles related to Linitis Plastica:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Metastatic lobular breast cancer presenting as gastric linitis plastica. (21571246)
2011
2
Metastatic gastric linitis plastica from bladder cancer mimicking a primary gastric carcinoma: a case report. (19885323)
2009
3
A rare case of breast cancer metastasis presenting as linitis plastica of the stomach and colon (with videos). (19699983)
2009
4
Primary linitis plastica of the right colon. (19886554)
2009
5
Secondary linitis plastica of the rectum: EUS features and tissue diagnosis (with video). (18635171)
2008
6
Scintigraphic appearance of "linitis plastica" in a patient with gastric non-Hodgkin's lymphoma on 18F-FDG imaging. (16470368)
2006
7
Linitis plastica in a 16-year-old. 1975. (17140154)
2006
8
Metastatic breast cancer presenting as linitis plastica of the stomach. (16086123)
2005
9
Detection of disseminated cancer cells in linitis plastica-type gastric carcinoma. (15466826)
2004
10
MR imaging of linitis plastica of the rectum. (12876021)
2003
11
Marked increase of trypsin(ogen) in serum of linitis plastica (gastric cancer, borrmann 4) patients. (10778967)
2000
12
Linitis plastica as the first indication of metastatic lobular carcinoma of the breast: case report and literature review. (10593250)
1999
13
EUS and EUS-guided fine-needle aspiration for the diagnosis of rectal linitis plastica secondary to prostate carcinoma. (10385739)
1999
14
Endoscopic ultrasonography in rectal linitis plastica. (9434221)
1997
15
Linitis plastica of the colon in ulcerative colitis. (9298379)
1997
16
Primary linitis plastica carcinoma of the colon: a case report. (9444922)
1997
17
Primary linitis plastica of the rectum: report of four cases and review of the literature. (8931217)
1996
18
Perianal extramammary Paget's disease associated with primary linitis plastica of the rectum: report of a case. (8883244)
1996
19
Linitis Plastica Presenting as Pouch Outlet Stenosis 13 Years after Vertical Banded Gastroplasty. (10731254)
1996
20
Hereditary linitis plastica of the stomach. (7485030)
1995
21
Flow cytometry as a prognostic predictor in gastric linitis plastica. (8057648)
1994
22
Primary linitis plastica carcinoma of the colon and rectum. (8082091)
1994
23
Linitis plastica after Hodgkin's disease. (8100333)
1993
24
Linitis plastica carcinoma of the colon mimicking Crohn's colitis. (1642587)
1992
25
Kaposi's sarcoma presenting as linitis plastica. (1962631)
1991
26
Gastric linitis plastica is not a surgical disease. (2552599)
1989
27
Corrosive gastritis mimicking linitis plastica carcinoma. (2550306)
1989
28
Sarcoidosis as a cause of linitis plastica. (2834399)
1988
29
Obstructive uropathy. An unusual presentation of primary linitis plastica of the colon. (2988885)
1985
30
Primary linitis plastica of the colon and rectum. Report of two cases. (6313308)
1983
31
Primary linitis plastica carcinoma of urinary bladder. (6312662)
1983
32
Primary linitis plastica of the rectum. (6295122)
1983
33
Linitis plastica infiltrating the entire gut. (6285694)
1982
34
Linitis plastica: one disease or more? (6281328)
1982
35
Diffusely infiltrating carcinoma of the colon (linitis plastica type). (7261824)
1981
36
Signet ring cell adenocarcinoma of the bladder: linitis plastica variant. (6260059)
1981
37
Primary linitis plastica of the rectum. (6249557)
1980
38
Squamous carcinoma of the stomach after luetic linitis plastica. (191328)
1977
39
Some specific radiological findings and consideration of linitis plastica of the gastrointestinal tract. (185007)
1976
40
Primary linitis plastica of the rectum. Report of two cases. (4359917)
1974
41
Gastric adenocarcinoma or linitis plastica in a dog. (4486933)
1973
42
Linitis plastica carcinoma of the colon: report of a case. (4328825)
1971
43
PRIMARY LINITIS PLASTICA CARCINOMA OF THE COLON. (14296754)
1965
44
INTRAMURAL (TUBAL) SPREAD OF LINITIS PLASTICA ALONG THE ALIMENTARY TRACT. (14275076)
1965
45
Primary linitis plastica of the rectum: report of a case. (14005784)
1962
46
Linitis plastica carcinoma of the stomach with extensive metastases simulating a colonic lesion. (14906648)
1952
47
Interrelationship of folic acid and vitamin B12 in macrocytic anemia associated with linitis plastica. (14932803)
1952
48
Primary linitis plastica type of carcinoma of the colon. (14789350)
1951
49
Carcinoma of the colon simulating linitis plastica; report of two cases. (20243096)
1947
50
BENIGN HYPERTROPHY OF THE STOMACH AND LINITIS PLASTICA. (17865667)
1927

Genetic Variations for Linitis Plastica

Expression for genes affiliated with Linitis Plastica

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Linitis Plastica

Search GEO for disease gene expression data for Linitis Plastica.

Pathways for genes affiliated with Linitis Plastica

Sources:
4Cell Signaling Technology
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Pathways related to Linitis Plastica according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CEACAM5, CDH1

Compounds for genes affiliated with Linitis Plastica

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Linitis Plastica according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1slex459.5CEACAM5, CDH1
2b 723459.5CEACAM5, CDH1
3crcs459.5CDH1, CEACAM5
4hematoxylin459.4CEACAM5, CDH1
5hydroxyapatite459.4CEACAM5, CDH1
6irinotecan45 50 1111.4CDH1, CEACAM5
7gefitinib45 50 1111.4CEACAM5, CDH1
8silver459.4CEACAM5, CDH1
9cytosine45 2410.4CDH1, CEACAM5
10latex459.4CEACAM5, CDH1
11p003459.4CDH1, CEACAM5
12p002459.3CEACAM5, CDH1
13adriamycin459.3CEACAM5, CDH1
14sialic acid459.3CDH1, CEACAM5
15adenine45 11 2411.1ADSL, CDH1
16carbohydrates459.1CEACAM5, CDH1
17agar459.1CEACAM5, CDH1
18hyaluronic acid45 2410.0CEACAM5, CDH1
195fluorouracil458.8CEACAM5, CDH1
20cysteine458.7PRSS2, CDH1, CEACAM5

GO Terms for genes affiliated with Linitis Plastica

Sources:
16Gene Ontology
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Cellular components related to Linitis Plastica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.1CEACAM5, CDH1

Products for genes affiliated with Linitis Plastica

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Sources for Linitis Plastica

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet