MCID: LNT001
MIFTS: 36

Linitis Plastica malady

Gastrointestinal diseases category

Summaries for Linitis Plastica

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63Wikipedia, 32MalaCards
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Wikipedia:63 Linitis plastica, also known as Brinton\'s disease or leather bottle stomach, is a morphological variant... more...

MalaCards: Linitis Plastica, also known as leather-bottle stomach, is related to gastric adenocarcinoma and signet ring cell adenocarcinoma. An important gene associated with Linitis Plastica is PRSS2 (protease, serine, 2 (trypsin 2)), and among its related pathways is Adhesion. The compounds slex and b 723 have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and bone.

Aliases & Classifications for Linitis Plastica

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

linitis plastica 8 60
leather-bottle stomach 8


External Ids:

Disease Ontology8 DOID:4023
MeSH34 D008039
SNOMED-CT56 307594007, 37995004
NCIt39 C3190

Related Diseases for Linitis Plastica

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to linitis plastica

Clinical Features for Linitis Plastica

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Drugs & Therapeutics for Linitis Plastica

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Linitis Plastica

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Anatomical Context for Linitis Plastica

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32MalaCards
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MalaCards organs/tissues related to Linitis Plastica:

32
Colon, Breast, Bone, Lymph node, Skin, Prostate, Appendix

Animal Models for Linitis Plastica or affiliated genes

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Publications for Linitis Plastica

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50PubMed
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Articles related to Linitis Plastica:

(show top 50)    (show all 163)
idTitleAuthorsYear
1
Managing Gastric Linitis Plastica: Keep the scalpel sheathed. (23984032)
2013
2
Fluoro-deoxy-glucose Positron Emission Tomography/Computed Tomography Pattern in a Patient with Linitis Plastica of the Stomach Caused by Primary Signet Cell Adenocarcinoma. (22942780)
2012
3
Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment. (21345767)
2011
4
Breast carcinoma presenting as linitis plastica. (19695970)
2010
5
Facing the challenge of managing linitis plastica--review of the literature. (20214236)
2009
6
The number of metastatic lymph nodes is a significant risk factor for bone metastasis and poor outcome after surgery for linitis plastica-type gastric carcinoma. (18563480)
2008
7
Diagnosis of linitis plastica-type gastric adenocarcinoma by endoscopic ultrasound-guided fine needle aspiration: a case report. (19068680)
2008
8
Relatively small size linitis plastica of the stomach: multislice CT detection of tissue fibrosis. (17151892)
2007
9
Cytologic diagnosis of gastric linitis plastica by endoscopic ultrasound guided fine-needle aspiration. (16511853)
2006
10
Primary linitis plastica of the jejunum. (16500409)
2006
11
Gastric tuberculosis presenting as linitis plastica: a case report and review of the literature. (16462546)
2006
12
Linitis plastica due to gastric diverticulosis. (16140854)
2005
13
Primary linitis plastica carcinoma of the colon accompanied by peritoneal abscess. (14595741)
2003
14
Linitis plastica of the rectum: utility of transrectal ultrasonography. (11794395)
2002
15
Linitis plastica presenting as malignant ascites. (11241451)
2001
16
The evolution of Linitis plastica as a consequence of advanced gastric carcinoma in pregnancy. (10486498)
1999
17
Study of survival and prognostic factors in patients undergoing resection for gastric linitis plastica: a review of 86 cases. (10667814)
1999
18
Non-Hodgkin lymphoma of the stomach: a cause of linitis plastica. (8888226)
1996
19
Endoscopic fine-needle aspiration cytology in the diagnosis of linitis plastica. (7922048)
1994
20
A case of linitis plastica of the rectum treated by pelvic exenteration after aggressive immunochemotherapy. (1498496)
1992
21
Diffusely infiltrating primary colorectal carcinoma of linitis plastica and lymphangiosis types. (1310433)
1992
22
CT demonstration of pelvic wall spread in primary colonic linitis plastica. (1313328)
1992
23
Gastric linitis plastica metastatic to the uvea. (1751916)
1991
24
Clinicopathological and histochemical studies of linitis plastica type gastric cancer with special reference to early gastric cancer in the region of the fundic gland. (1923458)
1991
25
Case report: gastric sarcoid simulating linitis plastica--a 5-year follow-up study. (1959308)
1991
26
Linitis plastica of the alimentary tract and scrotum. (2153597)
1990
27
Linitis plastica of the colon: computed tomography findings. (2153596)
1990
28
Gastric syphilis simulating linitis plastica type of gastric cancer. (2279662)
1990
29
Gastric linitis plastica with metastases to the colon: a mimic of Crohn's disease. (2551955)
1989
30
Primary linitis plastica carcinoma of the colon and rectum. (2548181)
1989
31
Linitis plastica of the stomach and entire intestine. (3022171)
1986
32
Primary signet-ring cell carcinoma of the urinary bladder (linitis plastica). (2992992)
1985
33
Linitis plastica involving the entire gastrointestinal tract. (6281326)
1982
34
Cytodiagnosis of gastric carcinoma, linitis plastica type (diffuse, infiltrating, poorly differentiated adenocarcinoma). (6269340)
1981
35
Linitis plastica caused by metastatic lobular carcinoma of the breast. (6261047)
1980
36
Primary linitis plastica of the colon: report of two cases and review of the literature. (207410)
1978
37
Primary linitis plastica of the colon and rectum. (199067)
1977
38
Difficulties with the diagnosis of linitis plastica carcinoma of the rectum and anal canal. (1272144)
1976
39
Linitis plastica in a 16-year-old. (171966)
1975
40
Primary linitis plastica carcinoma of the colon. (4370676)
1974
41
Radiologic seminar. CXXXVI. Linitis plastica: "leather-bottle stomach". (4361119)
1974
42
Primary linitis plastica carcinoma of the colon. (4374611)
1974
43
Indication for surgery in very far advanced carcinoma of the stomach. (Linitis plastica). (4338923)
1968-1969
44
Linitis plastica associated with complete situs inversus. Report of a case. (4296849)
1968
45
Primary linitis plastica of the colon: report of a case and review of the literature. (4293222)
1967
46
LINITIS PLASTICA OR DIFFUSELY INFILTRATING TYPE OF CARCINOMA OF THE COLON. (14062258)
1963
47
Linitis plastica of inflammatory nature: a pitfall in the diagnosis of gastric carcinoma. (13923111)
1961
48
On linitis plastica and on sclerosing carcinoma of the stomach (carcinoma disseminatum Krompecher; carcinoma fibrosum Konjetzny). (18119021)
1949
49
LINITIS PLASTICA. (17864459)
1921
50
A Clinical Lecture ON LINITIS PLASTICA, OR LEATHER-BOTTLE STOMACH: Delivered at the Middlesex Hospital on November 11th, 1913. (20766965)
1914

Genetic Variations for Linitis Plastica

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Expression for genes affiliated with Linitis Plastica

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Linitis Plastica

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Pathways for genes affiliated with Linitis Plastica

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4Cell Signaling Technology
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Pathways related to Linitis Plastica according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CEACAM5, CDH1

Compounds for genes affiliated with Linitis Plastica

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Linitis Plastica according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1slex449.5CEACAM5, CDH1
2b 723449.5CEACAM5, CDH1
3crcs449.5CDH1, CEACAM5
4hematoxylin449.4CEACAM5, CDH1
5hydroxyapatite449.4CEACAM5, CDH1
6irinotecan44 49 1111.4CDH1, CEACAM5
7gefitinib44 49 1111.4CEACAM5, CDH1
8silver449.4CEACAM5, CDH1
9cytosine44 2410.4CDH1, CEACAM5
10latex449.4CEACAM5, CDH1
11p003449.4CDH1, CEACAM5
12p002449.3CEACAM5, CDH1
13adriamycin449.3CEACAM5, CDH1
14sialic acid449.3CDH1, CEACAM5
15adenine44 11 2411.1ADSL, CDH1
16carbohydrates449.1CEACAM5, CDH1
17agar449.1CEACAM5, CDH1
18hyaluronic acid44 2410.0CEACAM5, CDH1
195fluorouracil448.8CEACAM5, CDH1
20cysteine448.7PRSS2, CDH1, CEACAM5

GO Terms for genes affiliated with Linitis Plastica

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16Gene Ontology
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Cellular components related to Linitis Plastica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.1CEACAM5, CDH1

Products for genes affiliated with Linitis Plastica

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Linitis Plastica

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet