MCID: LNT001
MIFTS: 32

Linitis Plastica malady

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Linitis Plastica

Aliases & Descriptions for Linitis Plastica:

Name: Linitis Plastica 12 42 14 69
Leather-Bottle Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4023
MeSH 42 D008039
NCIt 47 C3190
SNOMED-CT 64 307594007 37995004
UMLS 69 C0023743

Summaries for Linitis Plastica

MalaCards based summary : Linitis Plastica, also known as leather-bottle stomach, is related to gastritis and gastric linitis plastica. An important gene associated with Linitis Plastica is PRSS1 (Protease, Serine 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. The drugs Cisplatin and s 1 (combination) have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and bone.

Wikipedia : 71 Linitis plastica, also known as Brinton\'s disease or leather bottle stomach, is a morphological variant... more...

Related Diseases for Linitis Plastica

Diseases related to Linitis Plastica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Related Disease Score Top Affiliating Genes
1 gastritis 29.0 CDH1 KRT20 PKM PRSS1 PRSS2 SCN10A
2 gastric linitis plastica 12.3
3 gastric diffuse adenocarcinoma 11.1
4 adenocarcinoma 10.4
5 gastric cancer 10.3
6 breast cancer 10.2
7 colitis 10.2
8 gastric adenocarcinoma 10.2
9 primary congenital glaucoma 10.2 PRSS1 PRSS2
10 diastrophic dysplasia 10.2 PRSS1 PRSS2
11 ulcerative colitis 10.1
12 lymphoma 10.1
13 netherton syndrome 10.1 PRSS1 PRSS2
14 ovarian squamous cell carcinoma 10.1 CDH1 KRT20
15 infiltrative basal cell carcinoma 10.1 CDH1 KRT20
16 granulocytopenia 10.1 CDH1 KRT20
17 sarcoma 10.0
18 signet ring cell adenocarcinoma 10.0
19 syphilis 10.0
20 peritonitis 10.0
21 embryonal testis carcinoma 10.0 CDH1 KRT20
22 sarcomatoid basal cell carcinoma 10.0 CDH1 KRT20
23 gallbladder signet ring cell adenocarcinoma 10.0 CDH1 KRT20
24 myotonic disease 10.0 CDH1 KRT20
25 advanced sleep phase syndrome 10.0 CDH1 KRT20
26 papillary transitional carcinoma 10.0 CDH1 KRT20
27 pituitary carcinoma 10.0 CDH1 KRT20
28 odontotrichoungual-digital-palmar syndrome 10.0 CDH1 KRT20
29 oral squamous cell carcinoma 10.0 CDH1 KRT20
30 immunodeficiency 37 10.0 CDH1 KRT20
31 tenosynovitis of foot and ankle 10.0 CDH1 KRT20
32 thyroid gland disease 10.0 PRSS1 PRSS2
33 gastroesophageal junction adenocarcinoma 10.0 CDH1 KRT20
34 dysembryoplastic neuroepithelial tumor 10.0 CDH1 KRT20
35 pulmonary fibrosis and/or bone marrow failure, telomere-related, 1 10.0 CDH1 KRT20
36 monoclonal paraproteinemia 9.9 CDH1 KRT20
37 solitary plasmacytoma of chest wall 9.9 CDH1 KRT20
38 placenta praevia 9.9 CDH1 KRT20
39 obesity 9.9
40 hodgkin lymphoma 9.9
41 pancreatic cancer 9.9
42 crohn's disease 9.9
43 morbid obesity 9.9
44 crohn's colitis 9.9
45 gastric lymphoma 9.9
46 disseminated intravascular coagulation 9.9
47 pernicious anemia 9.9
48 prostatitis 9.9
49 macrocytic anemia 9.9
50 transitional cell carcinoma 9.9

Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to Linitis Plastica

Symptoms & Phenotypes for Linitis Plastica

Drugs & Therapeutics for Linitis Plastica

Drugs for Linitis Plastica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
2
s 1 (combination) Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Trial of Neoadjuvant TS-1 and Cisplatin for Type 4 and Large Type 3 Gastric Cancer Completed NCT00252161 Phase 3
2 A Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Advanced Scirrhous Gastric Carcinoma Patients Completed NCT01576380 Phase 2

Search NIH Clinical Center for Linitis Plastica

Cochrane evidence based reviews: linitis plastica

Genetic Tests for Linitis Plastica

Anatomical Context for Linitis Plastica

MalaCards organs/tissues related to Linitis Plastica:

39
Colon, Breast, Bone, Skin, Lymph Node, Prostate, Appendix

Publications for Linitis Plastica

Articles related to Linitis Plastica:

(show top 50) (show all 185)
id Title Authors Year
1
Ductal Breast Carcinoma Metastatic to the Stomach Resembling Primary Linitis Plastica in a Male Patient. ( 27721883 )
2016
2
Computed tomography features of gastrointestinal linitis plastica: spectrum of findings in early and delayed phase imaging. ( 26814502 )
2016
3
Metastatic pancreatic cancer presenting as linitis plastica of the stomach. ( 26957034 )
2016
4
An Unusual Cause of Gastric Linitis Plastica. ( 27810370 )
2016
5
Jackhammer oesophagus in a case of linitis plastica. ( 27174454 )
2016
6
Linitis Plastica of the bypassed stomach 7 years after Roux-en-Y gastric bypass. A Case Report. ( 27397038 )
2016
7
Survival following operative management of gastric linitis plastica compared with non-operative management. ( 27809576 )
2016
8
Advanced gastric cancer linitis plastica presented with disseminated intravascular coagulation. ( 27803086 )
2016
9
Metastatic gastric carcinoma from breast cancer mimicking primary linitis plastica: A case report. ( 26788154 )
2015
10
Primary linitis plastica of the entire colon in a background of ulcerative colitis: a case report. ( 25649787 )
2015
11
Recurrent bladder cancer presenting as rectal linitis plastica. ( 25734804 )
2015
12
Is Linitis Plastica a Contraindication for Surgical Resection: A Multi-Institution Study of the U.S. Gastric Cancer Collaborative. ( 26530447 )
2015
13
Characteristic waffle-like appearance of gastric linitis plastica: A case report. ( 25435971 )
2015
14
Primary linitis plastica of the rectum. ( 26895130 )
2015
15
Endoscopic ultrasound of isolated gastric corrosive stricture mimicking linitis plastica. ( 25789288 )
2015
16
Primary Linitis Plastica of the Rectum: Focus on Magnetic Resonance Imaging Patterns and Treatment Options. ( 26322720 )
2015
17
Submucosal Endoscopic Sampling for Indefinite Gastric Linitis Plastica Infiltrating into the Submucosal Layer. ( 26405710 )
2015
18
Gastric Crohns presenting as linitis plastica. ( 26710492 )
2015
19
Gastric lymphocytic phlebitis as a differential diagnosis of linitis plastica. ( 24896765 )
2014
20
Linitis Plastica of the Rectum As a Clinical Presentation of Metastatic Lobular Carcinoma of the Breast. ( 24982453 )
2014
21
Linitis plastica presenting two years after elective Roux-en-Y gastric bypass for treatment of morbid obesity: a case report and review of the literature. ( 24060402 )
2013
22
Managing Gastric Linitis Plastica: Keep the scalpel sheathed. ( 23984032 )
2013
23
Endoscopic ultrasonographic features of gastric linitis plastica in fifty-five Chinese patients. ( 24009205 )
2013
24
F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the staging of linitis plastica caused by primary gastric adenocarcinoma. ( 25125999 )
2013
25
Fluoro-deoxy-glucose Positron Emission Tomography/Computed Tomography Pattern in a Patient with Linitis Plastica of the Stomach Caused by Primary Signet Cell Adenocarcinoma. ( 22942780 )
2012
26
Secondary rectal linitis plastica as first manifestation of urinary bladder carcinoma. ( 24714188 )
2012
27
Case report and review of the literature: Rectal linitis plastica secondary to the lipoid cell variant of transitional cell carcinoma of the urinary bladder. ( 23282659 )
2012
28
Gastric linitis plastica: which role for surgical resection? ( 21717092 )
2012
29
Metastatic lobular breast cancer presenting as gastric linitis plastica. ( 21571246 )
2011
30
Metastatic breast carcinoma simulating linitis plastica of the colon: report of a case. ( 21431489 )
2011
31
Primary linitis plastica of the sigmoid colon. ( 21277393 )
2011
32
Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment. ( 21345767 )
2011
33
Breast carcinoma presenting as linitis plastica. ( 19695970 )
2010
34
Metastatic gastric linitis plastica from bladder cancer mimicking a primary gastric carcinoma: a case report. ( 19885323 )
2009
35
A rare case of breast cancer metastasis presenting as linitis plastica of the stomach and colon (with videos). ( 19699983 )
2009
36
Idiopathic fibrosing hypertrophic gastritis: a new entity that mimics linitis plastica carcinoma. ( 19370529 )
2009
37
Facing the challenge of managing linitis plastica--review of the literature. ( 20214236 )
2009
38
Primary linitis plastica of the right colon. ( 19886554 )
2009
39
Colorectal linitis plastica complicating chronic ulcerative colitis. ( 18798572 )
2009
40
Diagnosis of linitis plastica-type gastric adenocarcinoma by endoscopic ultrasound-guided fine needle aspiration: a case report. ( 19068680 )
2008
41
The number of metastatic lymph nodes is a significant risk factor for bone metastasis and poor outcome after surgery for linitis plastica-type gastric carcinoma. ( 18563480 )
2008
42
Linitis plastica of the rectum secondary to bladder carcinoma: a report of two cases and its MR features. ( 18796553 )
2008
43
Secondary linitis plastica of the rectum: EUS features and tissue diagnosis (with video). ( 18635171 )
2008
44
Relatively small size linitis plastica of the stomach: multislice CT detection of tissue fibrosis. ( 17151892 )
2007
45
Gastric linitis plastica from metastatic breast carcinoma: FDG and FES PET appearances. ( 17515338 )
2007
46
TS-1 as first-line therapy for gastric linitis plastica: historical control study. ( 16702816 )
2006
47
Primary linitis plastica of the jejunum. ( 16500409 )
2006
48
Gastric tuberculosis presenting as linitis plastica: a case report and review of the literature. ( 16462546 )
2006
49
Cytologic diagnosis of gastric linitis plastica by endoscopic ultrasound guided fine-needle aspiration. ( 16511853 )
2006
50
Linitis plastica in a 16-year-old. 1975. ( 17140154 )
2006

Variations for Linitis Plastica

Expression for Linitis Plastica

Search GEO for disease gene expression data for Linitis Plastica.

Pathways for Linitis Plastica

Pathways related to Linitis Plastica according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.45 CDH1 PRSS1 PRSS2
2
Show member pathways
11.15 PRSS1 PRSS2
3 10.94 PRSS1 PRSS2

GO Terms for Linitis Plastica

Biological processes related to Linitis Plastica according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 digestion GO:0007586 8.96 PRSS1 PRSS2
2 extracellular matrix disassembly GO:0022617 8.8 CDH1 PRSS1 PRSS2

Molecular functions related to Linitis Plastica according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type peptidase activity GO:0008236 8.62 PRSS1 PRSS2

Sources for Linitis Plastica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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