MCID: LNT001
MIFTS: 36

Linitis Plastica malady

Gastrointestinal diseases category

Summaries for Linitis Plastica

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63Wikipedia, 32MalaCards
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Wikipedia:63 Linitis plastica, also known as Brinton\'s disease or leather bottle stomach, is a morphological variant... more...

MalaCards: Linitis Plastica, also known as leather-bottle stomach, is related to gastric adenocarcinoma and signet ring cell adenocarcinoma. An important gene associated with Linitis Plastica is PRSS2 (protease, serine, 2 (trypsin 2)), and among its related pathways is Adhesion. The compounds slex and b 723 have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and bone.

Aliases & Classifications for Linitis Plastica

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

linitis plastica 8 60
leather-bottle stomach 8


External Ids:

Disease Ontology8 DOID:4023
MeSH34 D008039
SNOMED-CT56 307594007, 37995004
NCIt39 C3190

Related Diseases for Linitis Plastica

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to linitis plastica

Clinical Features for Linitis Plastica

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Drugs & Therapeutics for Linitis Plastica

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Linitis Plastica

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Anatomical Context for Linitis Plastica

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32MalaCards
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MalaCards organs/tissues related to Linitis Plastica:

32
Colon, Breast, Bone, Lymph node, Skin, Prostate, Appendix

Animal Models for Linitis Plastica or affiliated genes

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Publications for Linitis Plastica

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50PubMed
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Articles related to Linitis Plastica:

(show top 50)    (show all 163)
idTitleAuthorsYear
1
Endoscopic ultrasonographic features of gastric linitis plastica in fifty-five Chinese patients. (24009205)
2013
2
Linitis plastica presenting two years after elective Roux-en-Y gastric bypass for treatment of morbid obesity: a case report and review of the literature. (24060402)
2013
3
Gastric linitis plastica: which role for surgical resection? (21717092)
2012
4
Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment. (21345767)
2011
5
Facing the challenge of managing linitis plastica--review of the literature. (20214236)
2009
6
The number of metastatic lymph nodes is a significant risk factor for bone metastasis and poor outcome after surgery for linitis plastica-type gastric carcinoma. (18563480)
2008
7
Gastric outlet obstruction secondary to linitis plastica of the stomach as shown on transabdominal sonography. (15292571)
2004
8
Linitis plastica presenting as malignant ascites. (11241451)
2001
9
CT features of metastatic linitis plastica to the rectum in patients with peritoneal carcinomatosis. (10658725)
2000
10
Linitis plastica as the first indication of metastatic lobular carcinoma of the breast: case report and literature review. (10593250)
1999
11
Whipple's disease mimicking linitis plastica. (10223387)
1999
12
The evolution of Linitis plastica as a consequence of advanced gastric carcinoma in pregnancy. (10486498)
1999
13
Non-Hodgkin lymphoma of the stomach: a cause of linitis plastica. (8888226)
1996
14
Primary linitis plastica carcinoma of the colon and rectum. (7801917)
1995
15
Concomitant sclerosing mesenteritis and inflammatory pseudotumor simulating gastric lymphoma or linitis plastica. (7776655)
1995
16
Endoscopic fine-needle aspiration cytology in the diagnosis of linitis plastica. (7922048)
1994
17
Case in point. Linitis plastica (leather bottle stomach). (8253894)
1993
18
A case of linitis plastica of the rectum treated by pelvic exenteration after aggressive immunochemotherapy. (1498496)
1992
19
Linitis plastica carcinoma of the colon mimicking Crohn's colitis. (1642587)
1992
20
Urogenital linitis plastica metastatic from stomach. (1580041)
1992
21
Clinicopathological and histochemical studies of linitis plastica type gastric cancer with special reference to early gastric cancer in the region of the fundic gland. (1923458)
1991
22
Case report: gastric sarcoid simulating linitis plastica--a 5-year follow-up study. (1959308)
1991
23
Primary linitis plastica of the descending colon: a case report. (2160554)
1990
24
Linitis plastica of the esophagus. (2848410)
1988
25
Obstructive uropathy. An unusual presentation of primary linitis plastica of the colon. (2988885)
1985
26
Primary linitis plastica. (6325104)
1984
27
Linitis plastica carcinoma of the esophagus. (6301674)
1983
28
Linitis plastica infiltrating the entire gut. (6285694)
1982
29
Colorectal linitis plastica. (6279369)
1982
30
Cytodiagnosis of gastric carcinoma, linitis plastica type (diffuse, infiltrating, poorly differentiated adenocarcinoma). (6269340)
1981
31
Linitis plastica of the cecum. (6247052)
1980
32
Linitis plastica caused by metastatic lobular carcinoma of the breast. (6261047)
1980
33
Primary linitis plastica of the colon: report of two cases and review of the literature. (207410)
1978
34
Primary linitis plastica of the colon and rectum. (199067)
1977
35
Difficulties with the diagnosis of linitis plastica carcinoma of the rectum and anal canal. (1272144)
1976
36
Linitis plastica in a 16-year-old. (171966)
1975
37
Primary linitis plastica of the colon: Report of a case and review of the literature. (165050)
1975
38
Primary linitis plastica carcinoma of the colon. (4370676)
1974
39
Linitis plastica carcinoma of the intestine: Report of four cases. (4368867)
1974
40
Gastric adenocarcinoma or linitis plastica in a dog. (4486933)
1973
41
An early case of linitis plastica. Roentgenographic studies of the mucosa. (4338922)
1968-1969
42
Primary linitis plastica of the colon: report of a case and review of the literature. (4293222)
1967
43
PRIMARY LINITIS PLASTICA CARCINOMA OF THE COLON. (14296754)
1965
44
Linitis plastica carcinoma of the colon. Report of a case. (13882919)
1962
45
Linitis plastica of inflammatory nature: a pitfall in the diagnosis of gastric carcinoma. (13923111)
1961
46
Primary linitis plastica carcinoma of the colon. (14848972)
1951
47
Gastric linitis plastica. (14820009)
1951
48
On linitis plastica and on sclerosing carcinoma of the stomach (carcinoma disseminatum Krompecher; carcinoma fibrosum Konjetzny). (18119021)
1949
49
Linitis plastica with total gastrectomy. (20268361)
1947
50
VIII. Linitis Plastica (Cirrhosis of Stomach): With a Report of a Case Cured by Gastro-Jejunostomy. (17862763)
1911

Genetic Variations for Linitis Plastica

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Expression for genes affiliated with Linitis Plastica

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Linitis Plastica

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Pathways for genes affiliated with Linitis Plastica

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4Cell Signaling Technology
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Pathways related to Linitis Plastica according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CEACAM5, CDH1

Compounds for genes affiliated with Linitis Plastica

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Linitis Plastica according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1slex449.5CEACAM5, CDH1
2b 723449.5CEACAM5, CDH1
3crcs449.5CDH1, CEACAM5
4hematoxylin449.4CEACAM5, CDH1
5hydroxyapatite449.4CEACAM5, CDH1
6irinotecan44 49 1111.4CDH1, CEACAM5
7gefitinib44 49 1111.4CEACAM5, CDH1
8silver449.4CEACAM5, CDH1
9cytosine44 2410.4CDH1, CEACAM5
10latex449.4CEACAM5, CDH1
11p003449.4CDH1, CEACAM5
12p002449.3CEACAM5, CDH1
13adriamycin449.3CEACAM5, CDH1
14sialic acid449.3CDH1, CEACAM5
15adenine44 11 2411.1ADSL, CDH1
16carbohydrates449.1CEACAM5, CDH1
17agar449.1CEACAM5, CDH1
18hyaluronic acid44 2410.0CEACAM5, CDH1
195fluorouracil448.8CEACAM5, CDH1
20cysteine448.7PRSS2, CDH1, CEACAM5

GO Terms for genes affiliated with Linitis Plastica

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16Gene Ontology
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Cellular components related to Linitis Plastica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.1CEACAM5, CDH1

Products for genes affiliated with Linitis Plastica

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  • Antibodies
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Sources for Linitis Plastica

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet