MCID: LNT001
MIFTS: 32

Linitis Plastica malady

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Linitis Plastica

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Aliases & Descriptions for Linitis Plastica:

Name: Linitis Plastica 11 39 13 68
 
Leather-Bottle Stomach 11

Classifications:



External Ids:

Disease Ontology11 DOID:4023
MeSH39 D008039
SNOMED-CT62 307594007, 37995004
NCIt45 C3190

Summaries for Linitis Plastica

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Wikipedia:71 Linitis plastica, also known as Brinton\'s disease or leather bottle stomach, is a morphological variant... more...

MalaCards based summary: Linitis Plastica, also known as leather-bottle stomach, is related to gastric linitis plastica and gastric diffuse adenocarcinoma. An important gene associated with Linitis Plastica is PRSS1 (Protease, Serine 1), and among its related pathways are Matrix Metalloproteinases and Pancreatic secretion. Affiliated tissues include colon, breast and appendix.

Related Diseases for Linitis Plastica

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Diseases related to Linitis Plastica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1gastric linitis plastica12.3
2gastric diffuse adenocarcinoma11.1
3adenocarcinoma10.4
4gastric cancer10.3
5parkin type of early-onset parkinson disease10.3PRSS1, PRSS2
6netherton syndrome10.3PRSS1, PRSS2
7breast cancer10.2
8colitis10.2
9gastric adenocarcinoma10.2
10ulcerative colitis10.1
11lymphoma10.1
12gastritis10.1
13sarcoma10.1
14signet ring cell adenocarcinoma10.1
15syphilis10.1
16peritonitis10.1
17giant cell myocarditis10.0CDH1, KRT20
18adenoid basal cell carcinoma10.0CDH1, KRT20
19middle ear squamous cell carcinoma10.0CDH1, KRT20
20plethora of newborn10.0CDH1, KRT20
21comedo carcinoma10.0CDH1, KRT20
22lateral sinus thrombosis10.0CDH1, KRT20
23vulva basal cell carcinoma10.0CDH1, KRT20
24extrahepatic bile duct adenocarcinoma10.0CDH1, KRT20
25persian gulf syndrome10.0CDH1, KRT20
26gastrointestinal neuroendocrine tumor10.0CDH1, KRT20
27optic nerve glioma10.0PRSS1, PRSS2
28peritoneal serous adenocarcinoma10.0CDH1, KRT20
29ectodermal dysplasia with natal teeth, turnpenny type9.9CDH1, KRT20
30arteritic anterior ischemic optic neuropathy9.9CDH1, KRT20
31adult mesoblastic nephroma9.9CDH1, KRT20
32obesity9.9
33hodgkin lymphoma9.9
34pancreatic cancer9.9
35crohn's disease9.9
36morbid obesity9.9
37crohn's colitis9.9
38gastric lymphoma9.9
39disseminated intravascular coagulation9.9
40pernicious anemia9.9
41prostatitis9.9
42macrocytic anemia9.9
43transitional cell carcinoma9.9
44tuberculosis9.9
45pancreatitis9.9
46mesothelioma, somatic9.9CDH1, KRT20
47tropical calcific pancreatitis9.9PRSS1, PRSS2
48plasma protein metabolism disease9.9CDH1, KRT20
49plasmacytoma9.9CDH1, KRT20
50nasal cavity adenocarcinoma9.8CDH1, KRT20

Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to linitis plastica

Symptoms & Phenotypes for Linitis Plastica

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Drugs & Therapeutics for Linitis Plastica

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Drugs for Linitis Plastica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
CisplatinapprovedPhase 3269015663-27-184093, 441203, 2767
Synonyms:
(SP-4-1)-diamminedichloridoplatinum
(SP-4-1)-diamminedichloroplatinum
(SP-4-2)-diamminedichloridoplatinum
(SP-4-2)-diamminedichloroplatinum
Abiplatin
Biocisplatinum
Briplatin
CACP
CDDP
CHEBI:35852
CID441203
CPD0-1392
CPDC
CPDD
Carboquone
Cis Pt II
Cis-DDP
Cis-Diaminedichloroplatinum
Cis-Diamminedichloroplatinum
Cismaplat
Cisplatine
Cisplatino
Cisplatinum
Cisplatyl
Citoplationo
DB00515
DDP
DDPT
Diamminedichloroplatinum
 
EU-0100918
Lederplatin
Neoplatin
Peyrone's chloride
Peyrone's salt
Plastin
Platamine
Platiblastin
Platidiam
Platinex
Platinol
Platinol-AQ
Platinoxan
Platinum Ammine Chloride
Platinum Ammonium Chloride
Platinum Diamine Dichloride
Randa
Trans-DDP
Trans-Diaminedichloroplatinum
Trans-Diamminedichloroplatinum
Trans-Dichlorodiammine Platinum
Trans-Platinumdiammine Dichloride
cis-DDP
cis-Diamminedichloroplatinum
cis-Dichlorodiammineplatinum(II)
cis-[PtCl2(NH3)2]
cis-diamminedichloridoplatinum(II)
cis-diamminedichloroplatinum(II)
nchembio773-comp1
trans-diamminedichloridoplatinum(II)
2
s 1 (combination)Phase 3364
Synonyms:
 
Gimeracil / oteracil / tegafur
TS 1

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Trial of Neoadjuvant TS-1 and Cisplatin for Type 4 and Large Type 3 Gastric CancerCompletedNCT00252161Phase 3
2A Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Advanced Scirrhous Gastric Carcinoma PatientsCompletedNCT01576380Phase 2

Search NIH Clinical Center for Linitis Plastica


Cochrane evidence based reviews: linitis plastica

Genetic Tests for Linitis Plastica

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Anatomical Context for Linitis Plastica

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MalaCards organs/tissues related to Linitis Plastica:

36
Colon, Breast, Appendix, Prostate, Skin, Bone, Lymph node

Publications for Linitis Plastica

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Articles related to Linitis Plastica:

(show top 50)    (show all 184)
idTitleAuthorsYear
1
Jackhammer oesophagus in a case of linitis plastica. (27174454)
2016
2
Metastatic pancreatic cancer presenting as linitis plastica of the stomach. (26957034)
2016
3
Ductal Breast Carcinoma Metastatic to the Stomach Resembling Primary Linitis Plastica in a Male Patient. (27721883)
2016
4
Linitis Plastica of the bypassed stomach 7 years after Roux-en-Y gastric bypass. A Case Report. (27397038)
2016
5
Survival following operative management of gastric linitis plastica compared with non-operative management. (27809576)
2016
6
An Unusual Cause of Gastric Linitis Plastica. (27810370)
2016
7
Computed tomography features of gastrointestinal linitis plastica: spectrum of findings in early and delayed phase imaging. (26814502)
2016
8
Advanced gastric cancer linitis plastica presented with disseminated intravascular coagulation. (27803086)
2016
9
Recurrent bladder cancer presenting as rectal linitis plastica. (25734804)
2015
10
Characteristic waffle-like appearance of gastric linitis plastica: A case report. (25435971)
2015
11
Endoscopic ultrasound of isolated gastric corrosive stricture mimicking linitis plastica. (25789288)
2015
12
Primary linitis plastica of the rectum. (26895130)
2015
13
Gastric Crohns presenting as linitis plastica. (26710492)
2015
14
Primary linitis plastica of the entire colon in a background of ulcerative colitis: a case report. (25649787)
2015
15
Metastatic gastric carcinoma from breast cancer mimicking primary linitis plastica: A case report. (26788154)
2015
16
Submucosal Endoscopic Sampling for Indefinite Gastric Linitis Plastica Infiltrating into the Submucosal Layer. (26405710)
2015
17
Primary Linitis Plastica of the Rectum: Focus on Magnetic Resonance Imaging Patterns and Treatment Options. (26322720)
2015
18
Is Linitis Plastica a Contraindication for Surgical Resection: A Multi-Institution Study of the U.S. Gastric Cancer Collaborative. (26530447)
2015
19
Linitis Plastica of the Rectum As a Clinical Presentation of Metastatic Lobular Carcinoma of the Breast. (24982453)
2014
20
Gastric lymphocytic phlebitis as a differential diagnosis of linitis plastica. (24896765)
2014
21
Managing Gastric Linitis Plastica: Keep the scalpel sheathed. (23984032)
2013
22
Endoscopic ultrasonographic features of gastric linitis plastica in fifty-five Chinese patients. (24009205)
2013
23
Linitis plastica presenting two years after elective Roux-en-Y gastric bypass for treatment of morbid obesity: a case report and review of the literature. (24060402)
2013
24
F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the staging of linitis plastica caused by primary gastric adenocarcinoma. (25125999)
2013
25
Secondary rectal linitis plastica as first manifestation of urinary bladder carcinoma. (24714188)
2012
26
Gastric linitis plastica: which role for surgical resection? (21717092)
2012
27
Fluoro-deoxy-glucose Positron Emission Tomography/Computed Tomography Pattern in a Patient with Linitis Plastica of the Stomach Caused by Primary Signet Cell Adenocarcinoma. (22942780)
2012
28
Case report and review of the literature: Rectal linitis plastica secondary to the lipoid cell variant of transitional cell carcinoma of the urinary bladder. (23282659)
2012
29
Metastatic lobular breast cancer presenting as gastric linitis plastica. (21571246)
2011
30
Metastatic breast carcinoma simulating linitis plastica of the colon: report of a case. (21431489)
2011
31
Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment. (21345767)
2011
32
Primary linitis plastica of the sigmoid colon. (21277393)
2011
33
Breast carcinoma presenting as linitis plastica. (19695970)
2010
34
Colorectal linitis plastica complicating chronic ulcerative colitis. (18798572)
2009
35
Metastatic gastric linitis plastica from bladder cancer mimicking a primary gastric carcinoma: a case report. (19885323)
2009
36
A rare case of breast cancer metastasis presenting as linitis plastica of the stomach and colon (with videos). (19699983)
2009
37
Idiopathic fibrosing hypertrophic gastritis: a new entity that mimics linitis plastica carcinoma. (19370529)
2009
38
Facing the challenge of managing linitis plastica--review of the literature. (20214236)
2009
39
Primary linitis plastica of the right colon. (19886554)
2009
40
Secondary linitis plastica of the rectum: EUS features and tissue diagnosis (with video). (18635171)
2008
41
Diagnosis of linitis plastica-type gastric adenocarcinoma by endoscopic ultrasound-guided fine needle aspiration: a case report. (19068680)
2008
42
Linitis plastica of the rectum secondary to bladder carcinoma: a report of two cases and its MR features. (18796553)
2008
43
The number of metastatic lymph nodes is a significant risk factor for bone metastasis and poor outcome after surgery for linitis plastica-type gastric carcinoma. (18563480)
2008
44
Relatively small size linitis plastica of the stomach: multislice CT detection of tissue fibrosis. (17151892)
2007
45
Gastric linitis plastica from metastatic breast carcinoma: FDG and FES PET appearances. (17515338)
2007
46
Linitis plastica in a 16-year-old. 1975. (17140154)
2006
47
TS-1 as first-line therapy for gastric linitis plastica: historical control study. (16702816)
2006
48
Cytologic diagnosis of gastric linitis plastica by endoscopic ultrasound guided fine-needle aspiration. (16511853)
2006
49
Primary linitis plastica of the jejunum. (16500409)
2006
50
Gastric tuberculosis presenting as linitis plastica: a case report and review of the literature. (16462546)
2006

Variations for Linitis Plastica

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Expression for genes affiliated with Linitis Plastica

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Search GEO for disease gene expression data for Linitis Plastica.

Pathways for genes affiliated with Linitis Plastica

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GO Terms for genes affiliated with Linitis Plastica

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Biological processes related to Linitis Plastica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:000758610.1PRSS1, PRSS2
2extracellular matrix disassemblyGO:00226179.1CDH1, PRSS1, PRSS2

Molecular functions related to Linitis Plastica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type peptidase activityGO:00082369.6PRSS1, PRSS2

Sources for Linitis Plastica

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet