MCID: LNT001
MIFTS: 32

Linitis Plastica

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Linitis Plastica

MalaCards integrated aliases for Linitis Plastica:

Name: Linitis Plastica 12 42 14 69
Leather-Bottle Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4023
MeSH 42 D008039
NCIt 47 C3190
SNOMED-CT 64 307594007 37995004
UMLS 69 C0023743

Summaries for Linitis Plastica

MalaCards based summary : Linitis Plastica, also known as leather-bottle stomach, is related to gastric linitis plastica and gastric diffuse adenocarcinoma. An important gene associated with Linitis Plastica is PRSS1 (Protease, Serine 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. The drugs Cisplatin and s 1 (combination) have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and appendix.

Wikipedia : 72 Linitis plastica, also known as Brinton\'s disease or leather bottle stomach, is a morphological variant... more...

Related Diseases for Linitis Plastica

Diseases related to Linitis Plastica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Related Disease Score Top Affiliating Genes
1 gastric linitis plastica 12.3
2 gastric diffuse adenocarcinoma 11.1
3 adenocarcinoma 10.4
4 netherton syndrome 10.3 PRSS1 PRSS2
5 tropical calcific pancreatitis 10.2 PRSS1 PRSS2
6 breast cancer 10.2
7 colitis 10.2
8 gastric adenocarcinoma 10.2
9 ulcerative colitis 10.1
10 lymphoma 10.1
11 gastritis 10.1
12 follicular basal cell carcinoma 10.1 CDH1 KRT20
13 ampulla of vater squamous cell carcinoma 10.1 CDH1 KRT20
14 gorlin bushkell jensen syndrome 10.1 CDH1 KRT20
15 cystic basal cell carcinoma 10.0 CDH1 KRT20
16 cribriform carcinoma 10.0 CDH1 KRT20
17 sarcoma 10.0
18 signet ring cell adenocarcinoma 10.0
19 syphilis 10.0
20 peritonitis 10.0
21 pancreatic signet ring cell adenocarcinoma 10.0 CDH1 KRT20
22 avian influenza 10.0 CDH1 KRT20
23 prostate transitional cell carcinoma 10.0 CDH1 KRT20
24 urethra adenocarcinoma 10.0 CDH1 KRT20
25 ectodermal dysplasia with natal teeth, turnpenny type 10.0 CDH1 KRT20
26 arteritic anterior ischemic optic neuropathy 10.0 CDH1 KRT20
27 mesothelioma, somatic 10.0 CDH1 KRT20
28 apocrine adenocarcinoma 9.9 CDH1 KRT20
29 atypical polypoid adenomyoma 9.9 PRSS1 PRSS2
30 brown-vialetto-van laere syndrome 9.9 CDH1 KRT20
31 hepatitis c virus 9.9
32 obesity 9.9
33 hodgkin lymphoma 9.9
34 pancreatic cancer 9.9
35 chronic lymphocytic leukemia 9.9
36 crohn's disease 9.9
37 hepatitis 9.9
38 leukemia 9.9
39 morbid obesity 9.9
40 crohn's colitis 9.9
41 dermatomyositis 9.9
42 gastric lymphoma 9.9
43 disseminated intravascular coagulation 9.9
44 pernicious anemia 9.9
45 prostatitis 9.9
46 hepatitis c 9.9
47 macrocytic anemia 9.9
48 transitional cell carcinoma 9.9
49 tuberculosis 9.9
50 pancreatitis 9.9

Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to Linitis Plastica

Symptoms & Phenotypes for Linitis Plastica

Drugs & Therapeutics for Linitis Plastica

Drugs for Linitis Plastica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
2
s 1 (combination) Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 A Trial of Neoadjuvant TS-1 and Cisplatin for Type 4 and Large Type 3 Gastric Cancer Completed NCT00252161 Phase 3 Neoadjuvant chemotherapy(TS-1+CDDP) followed by gastrectomy
2 A Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Advanced Scirrhous Gastric Carcinoma Patients Completed NCT01576380 Phase 2 TKI258

Search NIH Clinical Center for Linitis Plastica

Cochrane evidence based reviews: linitis plastica

Genetic Tests for Linitis Plastica

Anatomical Context for Linitis Plastica

MalaCards organs/tissues related to Linitis Plastica:

39
Colon, Breast, Appendix, Prostate, Skin, Bone, Lymph Node

Publications for Linitis Plastica

Articles related to Linitis Plastica:

(show top 50) (show all 192)
id Title Authors Year
1
Linitis Plastica of Muscle Fascia Presenting as Tiptoeing Gait. ( 28809600 )
2017
2
Image Diagnosis: A Gastric Signet-Ring Adenocarcinoma of Type Linitis Plastica Mimicking Splenomegaly in a Patient with Chronic Lymphocytic Leukemia. ( 28609263 )
2017
3
Dermatomyositis revealing both a metastatic linitis plastica and hepatitis C virus infection. ( 28731019 )
2017
4
Urothelial Carcinoma of the Ureter and Urinary Bladder With Rectal Linitis Plastica. ( 28153589 )
2017
5
Clinical Outcomes after Surgery for Linitis Plastica of the Stomach: Analysis of a Population Cancer Registry. ( 28234115 )
2017
6
The significance of a nineteenth century definition in the era of genomics: linitis plastica. ( 28679451 )
2017
7
Linitis Plastica of the bypassed stomach 7 years after Roux-en-Y gastric bypass. A Case Report. ( 27397038 )
2016
8
Jackhammer oesophagus in a case of linitis plastica. ( 27174454 )
2016
9
Linitis plastica like primary signet ring cell carcinoma of the gallbladder - an extremely rare variant. ( 28195258 )
2016
10
Ductal Breast Carcinoma Metastatic to the Stomach Resembling Primary Linitis Plastica in a Male Patient. ( 27721883 )
2016
11
Survival following operative management of gastric linitis plastica compared with non-operative management. ( 27809576 )
2016
12
Advanced gastric cancer linitis plastica presented with disseminated intravascular coagulation. ( 27803086 )
2016
13
Metastatic pancreatic cancer presenting as linitis plastica of the stomach. ( 26957034 )
2016
14
Computed tomography features of gastrointestinal linitis plastica: spectrum of findings in early and delayed phase imaging. ( 26814502 )
2016
15
An Unusual Cause of Gastric Linitis Plastica. ( 27810370 )
2016
16
Primary Linitis Plastica of the Rectum: Focus on Magnetic Resonance Imaging Patterns and Treatment Options. ( 26322720 )
2015
17
Is Linitis Plastica a Contraindication for Surgical Resection: A Multi-Institution Study of the U.S. Gastric Cancer Collaborative. ( 26530447 )
2015
18
Recurrent bladder cancer presenting as rectal linitis plastica. ( 25734804 )
2015
19
Characteristic waffle-like appearance of gastric linitis plastica: A case report. ( 25435971 )
2015
20
Metastatic gastric carcinoma from breast cancer mimicking primary linitis plastica: A case report. ( 26788154 )
2015
21
Gastric Crohns presenting as linitis plastica. ( 26710492 )
2015
22
Primary linitis plastica of the rectum. ( 26895130 )
2015
23
Endoscopic ultrasound of isolated gastric corrosive stricture mimicking linitis plastica. ( 25789288 )
2015
24
Submucosal Endoscopic Sampling for Indefinite Gastric Linitis Plastica Infiltrating into the Submucosal Layer. ( 26405710 )
2015
25
Primary linitis plastica of the entire colon in a background of ulcerative colitis: a case report. ( 25649787 )
2015
26
Gastric lymphocytic phlebitis as a differential diagnosis of linitis plastica. ( 24896765 )
2014
27
Linitis Plastica of the Rectum As a Clinical Presentation of Metastatic Lobular Carcinoma of the Breast. ( 24982453 )
2014
28
Managing Gastric Linitis Plastica: Keep the scalpel sheathed. ( 23984032 )
2013
29
Endoscopic ultrasonographic features of gastric linitis plastica in fifty-five Chinese patients. ( 24009205 )
2013
30
Linitis plastica presenting two years after elective Roux-en-Y gastric bypass for treatment of morbid obesity: a case report and review of the literature. ( 24060402 )
2013
31
F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the staging of linitis plastica caused by primary gastric adenocarcinoma. ( 25125999 )
2013
32
Secondary rectal linitis plastica as first manifestation of urinary bladder carcinoma. ( 24714188 )
2012
33
Gastric linitis plastica: which role for surgical resection? ( 21717092 )
2012
34
Case report and review of the literature: Rectal linitis plastica secondary to the lipoid cell variant of transitional cell carcinoma of the urinary bladder. ( 23282659 )
2012
35
Fluoro-deoxy-glucose Positron Emission Tomography/Computed Tomography Pattern in a Patient with Linitis Plastica of the Stomach Caused by Primary Signet Cell Adenocarcinoma. ( 22942780 )
2012
36
Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment. ( 21345767 )
2011
37
Primary linitis plastica of the sigmoid colon. ( 21277393 )
2011
38
Metastatic lobular breast cancer presenting as gastric linitis plastica. ( 21571246 )
2011
39
Metastatic breast carcinoma simulating linitis plastica of the colon: report of a case. ( 21431489 )
2011
40
Breast carcinoma presenting as linitis plastica. ( 19695970 )
2010
41
Idiopathic fibrosing hypertrophic gastritis: a new entity that mimics linitis plastica carcinoma. ( 19370529 )
2009
42
Facing the challenge of managing linitis plastica--review of the literature. ( 20214236 )
2009
43
Metastatic gastric linitis plastica from bladder cancer mimicking a primary gastric carcinoma: a case report. ( 19885323 )
2009
44
Colorectal linitis plastica complicating chronic ulcerative colitis. ( 18798572 )
2009
45
Primary linitis plastica of the right colon. ( 19886554 )
2009
46
A rare case of breast cancer metastasis presenting as linitis plastica of the stomach and colon (with videos). ( 19699983 )
2009
47
Secondary linitis plastica of the rectum: EUS features and tissue diagnosis (with video). ( 18635171 )
2008
48
Linitis plastica of the rectum secondary to bladder carcinoma: a report of two cases and its MR features. ( 18796553 )
2008
49
Diagnosis of linitis plastica-type gastric adenocarcinoma by endoscopic ultrasound-guided fine needle aspiration: a case report. ( 19068680 )
2008
50
The number of metastatic lymph nodes is a significant risk factor for bone metastasis and poor outcome after surgery for linitis plastica-type gastric carcinoma. ( 18563480 )
2008

Variations for Linitis Plastica

Expression for Linitis Plastica

Search GEO for disease gene expression data for Linitis Plastica.

Pathways for Linitis Plastica

Pathways related to Linitis Plastica according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.45 CDH1 PRSS1 PRSS2
2
Show member pathways
11.15 PRSS1 PRSS2
3 10.94 PRSS1 PRSS2

GO Terms for Linitis Plastica

Biological processes related to Linitis Plastica according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 digestion GO:0007586 8.96 PRSS1 PRSS2
2 response to organic substance GO:0010033 8.85 CDH1
3 extracellular matrix disassembly GO:0022617 8.8 CDH1 PRSS1 PRSS2

Molecular functions related to Linitis Plastica according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type peptidase activity GO:0008236 8.62 PRSS1 PRSS2

Sources for Linitis Plastica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....