MCID: LNT001
MIFTS: 32

Linitis Plastica malady

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Linitis Plastica

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Aliases & Descriptions for Linitis Plastica:

Name: Linitis Plastica 11 13 37 66
 
Leather-Bottle Stomach 11

Classifications:



External Ids:

Disease Ontology11 DOID:4023
MeSH37 D008039
SNOMED-CT60 307594007, 37995004
NCIt43 C3190

Summaries for Linitis Plastica

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Wikipedia:69 Linitis plastica, also known as Brinton\'s disease or leather bottle stomach, is a morphological variant... more...

MalaCards based summary: Linitis Plastica, also known as leather-bottle stomach, is related to gastric linitis plastica and gastric diffuse adenocarcinoma. An important gene associated with Linitis Plastica is PRSS1 (Protease, Serine 1), and among its related pathways are Matrix Metalloproteinases and Pancreatic secretion. Affiliated tissues include colon, breast and appendix.

Related Diseases for Linitis Plastica

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Diseases related to Linitis Plastica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1gastric linitis plastica12.4
2gastric diffuse adenocarcinoma11.2
3adenocarcinoma10.5
4gastric cancer10.4
5breast cancer10.3
6colitis10.3
7parkin type of early-onset parkinson disease10.3PRSS1, PRSS2
8netherton syndrome10.3PRSS1, PRSS2
9ulcerative colitis10.3
10gastric adenocarcinoma10.3
11gastritis10.3
12lymphoma10.2
13sarcoma10.2
14signet ring cell adenocarcinoma10.2
15syphilis10.2
16peritonitis10.2
17giant cell myocarditis10.2CDH1, KRT20
18adenoid basal cell carcinoma10.2CDH1, KRT20
19middle ear squamous cell carcinoma10.2CDH1, KRT20
20plethora of newborn10.1CDH1, KRT20
21comedo carcinoma10.1CDH1, KRT20
22lateral sinus thrombosis10.1CDH1, KRT20
23vulva basal cell carcinoma10.1CDH1, KRT20
24extrahepatic bile duct adenocarcinoma10.1CDH1, KRT20
25persian gulf syndrome10.1CDH1, KRT20
26gastrointestinal neuroendocrine tumor10.1CDH1, KRT20
27peritoneal serous adenocarcinoma10.1CDH1, KRT20
28ectodermal dysplasia with natal teeth, turnpenny type10.1CDH1, KRT20
29arteritic anterior ischemic optic neuropathy10.0CDH1, KRT20
30obesity10.0
31hodgkin lymphoma10.0
32pancreatic cancer10.0
33crohn's disease10.0
34morbid obesity10.0
35crohn's colitis10.0
36gastric lymphoma10.0
37prostatitis10.0
38macrocytic anemia10.0
39transitional cell carcinoma10.0
40tuberculosis10.0
41pancreatitis10.0
42situs inversus10.0
43adult mesoblastic nephroma10.0CDH1, KRT20
44mesothelioma, somatic10.0CDH1, KRT20
45optic nerve glioma10.0PRSS1, PRSS2
46plasma protein metabolism disease10.0CDH1, KRT20
47plasmacytoma10.0CDH1, KRT20
48nasal cavity adenocarcinoma9.9CDH1, KRT20
49tropical calcific pancreatitis9.9PRSS1, PRSS2
50hartnup disorder9.9CDH1, KRT20

Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to linitis plastica

Symptoms for Linitis Plastica

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Drugs & Therapeutics for Linitis Plastica

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Drugs for Linitis Plastica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
s 1 (combination)Phase 3343
Synonyms:
 
Gimeracil / oteracil / tegafur
TS 1
2
CisplatinPhase 3261415663-27-184093, 441203, 2767
Synonyms:
(SP-4-1)-diamminedichloridoplatinum
(SP-4-1)-diamminedichloroplatinum
(SP-4-2)-diamminedichloridoplatinum
(SP-4-2)-diamminedichloroplatinum
Abiplatin
Biocisplatinum
Briplatin
CACP
CDDP
CHEBI:35852
CID441203
CPD0-1392
CPDC
CPDD
Carboquone
Cis Pt II
Cis-DDP
Cis-Diaminedichloroplatinum
Cis-Diamminedichloroplatinum
Cismaplat
Cisplatine
Cisplatino
Cisplatinum
Cisplatyl
Citoplationo
DB00515
DDP
DDPT
Diamminedichloroplatinum
 
EU-0100918
Lederplatin
Neoplatin
Peyrone's chloride
Peyrone's salt
Plastin
Platamine
Platiblastin
Platidiam
Platinex
Platinol
Platinol-AQ
Platinoxan
Platinum Ammine Chloride
Platinum Ammonium Chloride
Platinum Diamine Dichloride
Randa
Trans-DDP
Trans-Diaminedichloroplatinum
Trans-Diamminedichloroplatinum
Trans-Dichlorodiammine Platinum
Trans-Platinumdiammine Dichloride
cis-DDP
cis-Diamminedichloroplatinum
cis-Dichlorodiammineplatinum(II)
cis-[PtCl2(NH3)2]
cis-diamminedichloridoplatinum(II)
cis-diamminedichloroplatinum(II)
nchembio773-comp1
trans-diamminedichloridoplatinum(II)

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Trial of Neoadjuvant TS-1 and Cisplatin for Type 4 and Large Type 3 Gastric CancerCompletedNCT00252161Phase 3
2A Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Advanced Scirrhous Gastric Carcinoma PatientsCompletedNCT01576380Phase 2

Search NIH Clinical Center for Linitis Plastica


Cochrane evidence based reviews: linitis plastica

Genetic Tests for Linitis Plastica

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Anatomical Context for Linitis Plastica

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MalaCards organs/tissues related to Linitis Plastica:

34
Colon, Breast, Appendix, Prostate, Skin, Bone, Lymph node

Animal Models for Linitis Plastica or affiliated genes

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Publications for Linitis Plastica

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Articles related to Linitis Plastica:

(show top 50)    (show all 181)
idTitleAuthorsYear
1
Jackhammer oesophagus in a case of linitis plastica. (27174454)
2016
2
Metastatic pancreatic cancer presenting as linitis plastica of the stomach. (26957034)
2016
3
Recurrent bladder cancer presenting as rectal linitis plastica. (25734804)
2015
4
Characteristic waffle-like appearance of gastric linitis plastica: A case report. (25435971)
2015
5
Endoscopic ultrasound of isolated gastric corrosive stricture mimicking linitis plastica. (25789288)
2015
6
Linitis Plastica of the Rectum As a Clinical Presentation of Metastatic Lobular Carcinoma of the Breast. (24982453)
2014
7
Managing Gastric Linitis Plastica: Keep the scalpel sheathed. (23984032)
2013
8
Endoscopic ultrasonographic features of gastric linitis plastica in fifty-five Chinese patients. (24009205)
2013
9
Metastatic lobular breast cancer presenting as gastric linitis plastica. (21571246)
2011
10
Colorectal linitis plastica complicating chronic ulcerative colitis. (18798572)
2009
11
Metastatic gastric linitis plastica from bladder cancer mimicking a primary gastric carcinoma: a case report. (19885323)
2009
12
A rare case of breast cancer metastasis presenting as linitis plastica of the stomach and colon (with videos). (19699983)
2009
13
Secondary linitis plastica of the rectum: EUS features and tissue diagnosis (with video). (18635171)
2008
14
Relatively small size linitis plastica of the stomach: multislice CT detection of tissue fibrosis. (17151892)
2007
15
Primary linitis plastica carcinoma of the colon accompanied by peritoneal abscess. (14595741)
2003
16
Linitis plastica presenting as malignant ascites. (11241451)
2001
17
Linitis plastica as the first indication of metastatic lobular carcinoma of the breast: case report and literature review. (10593250)
1999
18
Linitis plastica of the colon in ulcerative colitis. (9298379)
1997
19
Primary linitis plastica of the rectum: report of four cases and review of the literature. (8931217)
1996
20
Perianal extramammary Paget's disease associated with primary linitis plastica of the rectum: report of a case. (8883244)
1996
21
Hereditary linitis plastica of the stomach. (7485030)
1995
22
Flow cytometry as a prognostic predictor in gastric linitis plastica. (8057648)
1994
23
Primary linitis plastica of the colon. (8224702)
1993
24
Gastric Kaposi's sarcoma without skin lesions presenting as linitis plastica. (1612397)
1992
25
Clinicopathological and histochemical studies of linitis plastica type gastric cancer with special reference to early gastric cancer in the region of the fundic gland. (1923458)
1991
26
Linitis plastica of the alimentary tract and scrotum. (2153597)
1990
27
Linitis plastica of the stomach and entire intestine. (3022171)
1986
28
The diagnostic challenge of metastatic linitis plastica. Two cases and a consideration of the problem. (3019197)
1986
29
Obstructive uropathy. An unusual presentation of primary linitis plastica of the colon. (2988885)
1985
30
Primary linitis plastica of the colon and rectum. Report of two cases. (6313308)
1983
31
Linitis plastica infiltrating the entire gut. (6285694)
1982
32
Linitis plastica involving the entire gastrointestinal tract. (6281326)
1982
33
Primary colo-rectal linitis plastica type of carcinoma: report of two cases and review of the literature. (6285255)
1982
34
Linitis plastica: one disease or more? (6281328)
1982
35
Linitis plastica of the cecum. (6247052)
1980
36
Metastatic carcinoma simulating linitis plastica of the colon. A case report. (220870)
1979
37
Primary linitis plastica carcinoma of the colon. (4370676)
1974
38
Linitis plastica carcinoma of the intestine: Report of four cases. (4368867)
1974
39
Radiologic seminar. CXXXVI. Linitis plastica: "leather-bottle stomach". (4361119)
1974
40
Primary linitis plastica of the rectum. Report of two cases. (4359917)
1974
41
Primary linitis plastica of the rectum: report of two cases. (4334545)
1971
42
Primary linitis plastica of the colon and rectum. (4319203)
1970
43
INTRAMURAL (TUBAL) SPREAD OF LINITIS PLASTICA ALONG THE ALIMENTARY TRACT. (14275076)
1965
44
LINITIS PLASTICA OR DIFFUSELY INFILTRATING TYPE OF CARCINOMA OF THE COLON. (14062258)
1963
45
Total gastrectomy for linitis plastica. (14348814)
1955
46
Interrelationship of folic acid and vitamin B12 in macrocytic anemia associated with linitis plastica. (14932803)
1952
47
On linitis plastica and on sclerosing carcinoma of the stomach (carcinoma disseminatum Krompecher; carcinoma fibrosum Konjetzny). (18119021)
1949
48
BENIGN HYPERTROPHY OF THE STOMACH AND LINITIS PLASTICA. (17865667)
1927
49
A Clinical Lecture ON LINITIS PLASTICA, OR LEATHER-BOTTLE STOMACH: Delivered at the Middlesex Hospital on November 11th, 1913. (20766965)
1914
50
VIII. Linitis Plastica (Cirrhosis of Stomach): With a Report of a Case Cured by Gastro-Jejunostomy. (17862763)
1911

Variations for Linitis Plastica

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Expression for genes affiliated with Linitis Plastica

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Search GEO for disease gene expression data for Linitis Plastica.

Pathways for genes affiliated with Linitis Plastica

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GO Terms for genes affiliated with Linitis Plastica

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Biological processes related to Linitis Plastica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:00075869.6PRSS1, PRSS2
2extracellular matrix disassemblyGO:00226179.1CDH1, PRSS1, PRSS2

Molecular functions related to Linitis Plastica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type peptidase activityGO:00082369.6PRSS1, PRSS2

Sources for Linitis Plastica

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet