MCID: LNT001
MIFTS: 36

Linitis Plastica

Categories: Gastrointestinal diseases, Cancer diseases

Aliases & Classifications for Linitis Plastica

MalaCards integrated aliases for Linitis Plastica:

Name: Linitis Plastica 12 41 14 69
Leather-Bottle Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4023
MeSH 41 D008039
NCIt 46 C3190
SNOMED-CT 64 307594007 37995004
UMLS 69 C0023743

Summaries for Linitis Plastica

MalaCards based summary : Linitis Plastica, also known as leather-bottle stomach, is related to gastric diffuse adenocarcinoma and signet ring cell adenocarcinoma. An important gene associated with Linitis Plastica is PRSS1 (Protease, Serine 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Cytoskeletal Signaling. The drugs Cisplatin and s 1 (combination) have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and prostate.

Wikipedia : 72 Linitis plastica, also known as Brinton\'s disease or leather bottle stomach, is a morphological variant... more...

Related Diseases for Linitis Plastica

Diseases related to Linitis Plastica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 gastric diffuse adenocarcinoma 30.5 CDH1 KRT20 KRT7 MMP15
2 signet ring cell adenocarcinoma 29.8 CDH1 KRT20 KRT7
3 transitional cell carcinoma 29.5 CDH1 KRT20 KRT7
4 gastric linitis plastica 12.4
5 adenocarcinoma 10.4
6 gastric cancer 10.4
7 tropical calcific pancreatitis 10.3 PRSS1 PRSS2
8 colitis 10.3
9 gastric adenocarcinoma 10.3
10 ulcerative colitis 10.2
11 lymphoma 10.2
12 gastritis 10.2
13 cystic basal cell carcinoma 10.1 KRT20 KRT7
14 lung acinar adenocarcinoma 10.1 KRT20 KRT7
15 vaginal benign neoplasm 10.1 KRT20 KRT7
16 seminal vesicle adenocarcinoma 10.1 KRT20 KRT7
17 transverse colon cancer 10.1 KRT20 KRT7
18 ovarian large-cell neuroendocrine carcinoma 10.1 KRT20 KRT7
19 vaginal adenoma 10.1 KRT20 KRT7
20 vaginal tubulovillous adenoma 10.1 KRT20 KRT7
21 eyelid neoplasm 10.1 KRT20 KRT7
22 malignant syringoma 10.1 KRT20 KRT7
23 krukenberg carcinoma 10.1 KRT20 KRT7
24 glandular cystitis 10.1 KRT20 KRT7
25 small cell carcinoma of the bladder 10.1 KRT20 KRT7
26 morpheaform basal cell carcinoma 10.1 CDH1 KRT20
27 eccrine sweat gland neoplasm 10.1 KRT20 KRT7
28 goblet cell carcinoid 10.1 CDH1 KRT20
29 bladder cancer 10.1
30 breast cancer 10.1
31 sarcoma 10.1
32 syphilis 10.1
33 peritonitis 10.1
34 papillary adenocarcinoma 10.1 CDH1 KRT7
35 mucinous bronchioloalveolar adenocarcinoma 10.1 KRT20 KRT7
36 vulval paget's disease 10.1 KRT20 KRT7
37 bladder adenocarcinoma 10.1 KRT20 KRT7
38 bile duct cystadenocarcinoma 10.1 KRT20 KRT7
39 intratubular embryonal carcinoma 10.1 KRT20 KRT7
40 ovarian mucinous adenocarcinoma 10.1 KRT20 KRT7
41 thymus adenocarcinoma 10.1 KRT20 KRT7
42 meibomian cyst 10.1 KRT20 KRT7
43 bladder lymphoma 10.1 KRT20 KRT7
44 vulva adenocarcinoma 10.1 KRT20 KRT7
45 papillary serous adenocarcinoma 10.1 KRT20 KRT7
46 jejunal adenocarcinoma 10.1 KRT20 KRT7
47 bile duct adenocarcinoma 10.1 CDH1 KRT7
48 chronic cystitis 10.1 KRT20 KRT7
49 renal pelvis carcinoma 10.1 KRT20 KRT7
50 rectum adenocarcinoma 10.1 KRT20 KRT7

Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to Linitis Plastica

Symptoms & Phenotypes for Linitis Plastica

Drugs & Therapeutics for Linitis Plastica

Drugs for Linitis Plastica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
2
s 1 (combination) Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of Neoadjuvant TS-1 and Cisplatin for Type 4 and Large Type 3 Gastric Cancer Completed NCT00252161 Phase 3 Neoadjuvant chemotherapy(TS-1+CDDP) followed by gastrectomy
2 A Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Advanced Scirrhous Gastric Carcinoma Patients Completed NCT01576380 Phase 2 TKI258

Search NIH Clinical Center for Linitis Plastica

Cochrane evidence based reviews: linitis plastica

Genetic Tests for Linitis Plastica

Anatomical Context for Linitis Plastica

MalaCards organs/tissues related to Linitis Plastica:

38
Colon, Appendix, Prostate, Skin, Bone, Lymph Node

Publications for Linitis Plastica

Articles related to Linitis Plastica:

(show top 50) (show all 194)
# Title Authors Year
1
The significance of a nineteenth century definition in the era of genomics: linitis plastica. ( 28679451 )
2017
2
A case report of gastric linitis plastica diagnosed by endoscopic ultrasound-guided fine needle aspiration. ( 29390283 )
2017
3
Linitis Plastica of Muscle Fascia Presenting as Tiptoeing Gait. ( 28809600 )
2017
4
Dermatomyositis revealing both a metastatic linitis plastica and hepatitis C virus infection. ( 28731019 )
2017
5
Urothelial Carcinoma of the Ureter and Urinary Bladder With Rectal Linitis Plastica. ( 28153589 )
2017
6
Clinical Outcomes after Surgery for Linitis Plastica of the Stomach: Analysis of a Population Cancer Registry. ( 28234115 )
2017
7
Image Diagnosis: A Gastric Signet-Ring Adenocarcinoma of Type Linitis Plastica Mimicking Splenomegaly in a Patient with Chronic Lymphocytic Leukemia. ( 28609263 )
2017
8
Incomplete resection and linitis plastica are factors for poor survival after extended multiorgan resection in gastric cancer patients. ( 29150634 )
2017
9
Linitis Plastica of the bypassed stomach 7 years after Roux-en-Y gastric bypass. A Case Report. ( 27397038 )
2016
10
Advanced gastric cancer linitis plastica presented with disseminated intravascular coagulation. ( 27803086 )
2016
11
Jackhammer oesophagus in a case of linitis plastica. ( 27174454 )
2016
12
An Unusual Cause of Gastric Linitis Plastica. ( 27810370 )
2016
13
Computed tomography features of gastrointestinal linitis plastica: spectrum of findings in early and delayed phase imaging. ( 26814502 )
2016
14
Survival following operative management of gastric linitis plastica compared with non-operative management. ( 27809576 )
2016
15
Linitis plastica like primary signet ring cell carcinoma of the gallbladder - an extremely rare variant. ( 28195258 )
2016
16
Ductal Breast Carcinoma Metastatic to the Stomach Resembling Primary Linitis Plastica in a Male Patient. ( 27721883 )
2016
17
Metastatic pancreatic cancer presenting as linitis plastica of the stomach. ( 26957034 )
2016
18
Primary Linitis Plastica of the Rectum: Focus on Magnetic Resonance Imaging Patterns and Treatment Options. ( 26322720 )
2015
19
Primary linitis plastica of the rectum. ( 26895130 )
2015
20
Recurrent bladder cancer presenting as rectal linitis plastica. ( 25734804 )
2015
21
Endoscopic ultrasound of isolated gastric corrosive stricture mimicking linitis plastica. ( 25789288 )
2015
22
Gastric Crohns presenting as linitis plastica. ( 26710492 )
2015
23
Submucosal Endoscopic Sampling for Indefinite Gastric Linitis Plastica Infiltrating into the Submucosal Layer. ( 26405710 )
2015
24
Metastatic gastric carcinoma from breast cancer mimicking primary linitis plastica: A case report. ( 26788154 )
2015
25
Is Linitis Plastica a Contraindication for Surgical Resection: A Multi-Institution Study of the U.S. Gastric Cancer Collaborative. ( 26530447 )
2015
26
Primary linitis plastica of the entire colon in a background of ulcerative colitis: a case report. ( 25649787 )
2015
27
Characteristic waffle-like appearance of gastric linitis plastica: A case report. ( 25435971 )
2015
28
Linitis Plastica of the Rectum As a Clinical Presentation of Metastatic Lobular Carcinoma of the Breast. ( 24982453 )
2014
29
Gastric lymphocytic phlebitis as a differential diagnosis of linitis plastica. ( 24896765 )
2014
30
Linitis plastica presenting two years after elective Roux-en-Y gastric bypass for treatment of morbid obesity: a case report and review of the literature. ( 24060402 )
2013
31
Managing Gastric Linitis Plastica: Keep the scalpel sheathed. ( 23984032 )
2013
32
F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the staging of linitis plastica caused by primary gastric adenocarcinoma. ( 25125999 )
2013
33
Endoscopic ultrasonographic features of gastric linitis plastica in fifty-five Chinese patients. ( 24009205 )
2013
34
Secondary rectal linitis plastica as first manifestation of urinary bladder carcinoma. ( 24714188 )
2012
35
Fluoro-deoxy-glucose Positron Emission Tomography/Computed Tomography Pattern in a Patient with Linitis Plastica of the Stomach Caused by Primary Signet Cell Adenocarcinoma. ( 22942780 )
2012
36
Case report and review of the literature: Rectal linitis plastica secondary to the lipoid cell variant of transitional cell carcinoma of the urinary bladder. ( 23282659 )
2012
37
Gastric linitis plastica: which role for surgical resection? ( 21717092 )
2012
38
Metastatic lobular breast cancer presenting as gastric linitis plastica. ( 21571246 )
2011
39
Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment. ( 21345767 )
2011
40
Metastatic breast carcinoma simulating linitis plastica of the colon: report of a case. ( 21431489 )
2011
41
Primary linitis plastica of the sigmoid colon. ( 21277393 )
2011
42
Breast carcinoma presenting as linitis plastica. ( 19695970 )
2010
43
Colorectal linitis plastica complicating chronic ulcerative colitis. ( 18798572 )
2009
44
A rare case of breast cancer metastasis presenting as linitis plastica of the stomach and colon (with videos). ( 19699983 )
2009
45
Facing the challenge of managing linitis plastica--review of the literature. ( 20214236 )
2009
46
Metastatic gastric linitis plastica from bladder cancer mimicking a primary gastric carcinoma: a case report. ( 19885323 )
2009
47
Primary linitis plastica of the right colon. ( 19886554 )
2009
48
Idiopathic fibrosing hypertrophic gastritis: a new entity that mimics linitis plastica carcinoma. ( 19370529 )
2009
49
Secondary linitis plastica of the rectum: EUS features and tissue diagnosis (with video). ( 18635171 )
2008
50
The number of metastatic lymph nodes is a significant risk factor for bone metastasis and poor outcome after surgery for linitis plastica-type gastric carcinoma. ( 18563480 )
2008

Variations for Linitis Plastica

Expression for Linitis Plastica

Search GEO for disease gene expression data for Linitis Plastica.

Pathways for Linitis Plastica

Pathways related to Linitis Plastica according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.91 CDH1 MMP15 PRSS1 PRSS2
2 11.82 CDH1 KRT20 KRT7
3 11.24 PRSS1 PRSS2
4
Show member pathways
10.79 MMP15 PRSS1 PRSS2

GO Terms for Linitis Plastica

Biological processes related to Linitis Plastica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 digestion GO:0007586 9.16 PRSS1 PRSS2
2 collagen catabolic process GO:0030574 8.96 MMP15 PRSS2
3 extracellular matrix disassembly GO:0022617 8.92 CDH1 MMP15 PRSS1 PRSS2

Molecular functions related to Linitis Plastica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 8.8 MMP15 PRSS1 PRSS2

Sources for Linitis Plastica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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