MCID: LNT001
MIFTS: 30

Linitis Plastica malady

Cancer diseases, Gastrointestinal diseases categories

Aliases & Classifications for Linitis Plastica

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Aliases & Descriptions for Linitis Plastica:

Name: Linitis Plastica 10 65 36
 
Leather-Bottle Stomach 10


Classifications:



External Ids:

Disease Ontology10 DOID:4023
MeSH36 D008039
SNOMED-CT59 37995004, 307594007
NCIt42 C3190

Summaries for Linitis Plastica

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Wikipedia:68 Linitis plastica, also known as Brinton\'s disease or leather bottle stomach, is a morphological variant... more...

MalaCards based summary: Linitis Plastica, also known as leather-bottle stomach, is related to gastric linitis plastica and adenocarcinoma. An important gene associated with Linitis Plastica is PRSS1 (Protease, Serine, 1 (Trypsin 1)), and among its related pathways are Matrix Metalloproteinases and Pancreatic secretion. Affiliated tissues include colon, breast and appendix.

Related Diseases for Linitis Plastica

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Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to linitis plastica

Symptoms for Linitis Plastica

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Drugs & Therapeutics for Linitis Plastica

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Drugs for Linitis Plastica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
CisplatinapprovedPhase 3243715663-27-184093, 441203, 2767
Synonyms:
(SP-4-1)-diamminedichloridoplatinum
(SP-4-1)-diamminedichloroplatinum
(SP-4-2)-diamminedichloridoplatinum
(SP-4-2)-diamminedichloroplatinum
Abiplatin
Biocisplatinum
Briplatin
CACP
CDDP
CHEBI:35852
CID441203
CPD0-1392
CPDC
CPDD
Carboquone
Cis Pt II
Cis-DDP
Cis-Diaminedichloroplatinum
Cis-Diamminedichloroplatinum
Cismaplat
Cisplatin
Cisplatine
Cisplatino
Cisplatinum
Cisplatyl
Citoplationo
DB00515
DDP
DDPT
Diamminedichloroplatinum
 
EU-0100918
Lederplatin
Neoplatin
Peyrone's chloride
Peyrone's salt
Plastin
Platamine
Platiblastin
Platidiam
Platinex
Platinol
Platinol-AQ
Platinol-aq
Platinoxan
Platinum Ammine Chloride
Platinum Ammonium Chloride
Platinum Diamine Dichloride
Randa
Trans-DDP
Trans-Diaminedichloroplatinum
Trans-Diamminedichloroplatinum
Trans-Dichlorodiammine Platinum
Trans-Platinumdiammine Dichloride
cis-DDP
cis-Diamminedichloroplatinum
cis-Dichlorodiammineplatinum(II)
cis-[PtCl2(NH3)2]
cis-diamminedichloridoplatinum(II)
cis-diamminedichloroplatinum(II)
nchembio773-comp1
trans-diamminedichloridoplatinum(II)

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Trial of Neoadjuvant TS-1 and Cisplatin for Type 4 and Large Type 3 Gastric CancerRecruitingNCT00252161Phase 3
2A Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Advanced Scirrhous Gastric Carcinoma PatientsCompletedNCT01576380Phase 2

Search NIH Clinical Center for Linitis Plastica


Cochrane evidence based reviews: Linitis Plastica

Genetic Tests for Linitis Plastica

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Anatomical Context for Linitis Plastica

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MalaCards organs/tissues related to Linitis Plastica:

33
Colon, Breast, Appendix, Prostate, Skin, Bone, Lymph node

Animal Models for Linitis Plastica or affiliated genes

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Publications for Linitis Plastica

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Articles related to Linitis Plastica:

(show top 50)    (show all 173)
idTitleAuthorsYear
1
Recurrent bladder cancer presenting as rectal linitis plastica. (25734804)
2015
2
Primary linitis plastica of the entire colon in a background of ulcerative colitis: a case report. (25649787)
2015
3
Submucosal Endoscopic Sampling for Indefinite Gastric Linitis Plastica Infiltrating into the Submucosal Layer. (26405710)
2015
4
Linitis Plastica of the Rectum As a Clinical Presentation of Metastatic Lobular Carcinoma of the Breast. (24982453)
2014
5
Managing Gastric Linitis Plastica: Keep the scalpel sheathed. (23984032)
2013
6
Endoscopic ultrasonographic features of gastric linitis plastica in fifty-five Chinese patients. (24009205)
2013
7
Metastatic lobular breast cancer presenting as gastric linitis plastica. (21571246)
2011
8
Metastatic breast carcinoma simulating linitis plastica of the colon: report of a case. (21431489)
2011
9
Facing the challenge of managing linitis plastica--review of the literature. (20214236)
2009
10
Colorectal linitis plastica complicating chronic ulcerative colitis. (18798572)
2009
11
Linitis plastica of the rectum secondary to bladder carcinoma: a report of two cases and its MR features. (18796553)
2008
12
The number of metastatic lymph nodes is a significant risk factor for bone metastasis and poor outcome after surgery for linitis plastica-type gastric carcinoma. (18563480)
2008
13
Relatively small size linitis plastica of the stomach: multislice CT detection of tissue fibrosis. (17151892)
2007
14
TS-1 as first-line therapy for gastric linitis plastica: historical control study. (16702816)
2006
15
Cytologic diagnosis of gastric linitis plastica by endoscopic ultrasound guided fine-needle aspiration. (16511853)
2006
16
Linitis plastica due to gastric diverticulosis. (16140854)
2005
17
Gastric outlet obstruction secondary to linitis plastica of the stomach as shown on transabdominal sonography. (15292571)
2004
18
A new mutation of E-cadherin gene in familial gastric linitis plastica cancer with extra-digestive dissemination. (11434599)
2001
19
Linitis plastica presenting as malignant ascites. (11241451)
2001
20
Linitis plastica as the first indication of metastatic lobular carcinoma of the breast: case report and literature review. (10593250)
1999
21
Endoscopic ultrasonography in rectal linitis plastica. (9434221)
1997
22
Linitis plastica of the colon in ulcerative colitis. (9298379)
1997
23
Flow cytometry as a prognostic predictor in gastric linitis plastica. (8057648)
1994
24
Primary linitis plastica of the colon. (8224702)
1993
25
A case of linitis plastica of the rectum treated by pelvic exenteration after aggressive immunochemotherapy. (1498496)
1992
26
Kaposi's sarcoma presenting as linitis plastica. (1962631)
1991
27
Gastric linitis plastica metastatic to the uvea. (1751916)
1991
28
Linitis plastica of the alimentary tract and scrotum. (2153597)
1990
29
Primary linitis plastica of the descending colon: a case report. (2160554)
1990
30
Linitis plastica of the stomach and entire intestine. (3022171)
1986
31
Obstructive uropathy. An unusual presentation of primary linitis plastica of the colon. (2988885)
1985
32
Primary linitis plastica of the colon and rectum. Report of two cases. (6313308)
1983
33
Primary linitis plastica carcinoma of urinary bladder. (6312662)
1983
34
Primary signet ring cell adenocarcinoma of the bladder (linitis plastica of the bladder): report of a case and review of the literature. (6294348)
1982
35
Linitis plastica infiltrating the entire gut. (6285694)
1982
36
Linitis plastica in a 16-year-old. (171966)
1975
37
Primary linitis plastica carcinoma of the colon. (4370676)
1974
38
Gastric adenocarcinoma or linitis plastica in a dog. (4486933)
1973
39
Linitis plastica of the colon and rectum: report of two cases. (4337633)
1972
40
Primary linitis plastica of the rectum: report of two cases. (4334545)
1971
41
Linitis plastica carcinoma of the colon: report of a case. (4328825)
1971
42
Primary linitis plastica of the colon and rectum. (4319203)
1970
43
PRIMARY LINITIS PLASTICA CARCINOMA OF THE COLON. (14296754)
1965
44
LINITIS PLASTICA OR DIFFUSELY INFILTRATING TYPE OF CARCINOMA OF THE COLON. (14062258)
1963
45
Roentgenographic findings in an early case of linitis plastica. (14419028)
1960
46
Linitis plastica. (14406509)
1959
47
Linitis plastica carcinoma of the stomach with extensive metastases simulating a colonic lesion. (14906648)
1952
48
BENIGN HYPERTROPHY OF THE STOMACH AND LINITIS PLASTICA. (17865667)
1927
49
LINITIS PLASTICA. (17864459)
1921
50
VIII. Linitis Plastica (Cirrhosis of Stomach): With a Report of a Case Cured by Gastro-Jejunostomy. (17862763)
1911

Variations for Linitis Plastica

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Expression for genes affiliated with Linitis Plastica

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Search GEO for disease gene expression data for Linitis Plastica.

Pathways for genes affiliated with Linitis Plastica

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Pathways related to Linitis Plastica according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6PRSS1, PRSS2
29.6PRSS1, PRSS2
39.6PRSS1, PRSS2
4
Show member pathways
9.1CDH1, PRSS1, PRSS2

GO Terms for genes affiliated with Linitis Plastica

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Cellular components related to Linitis Plastica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular exosomeGO:00700627.6CDH1, PKM, PRSS1, PSCA, SCN10A

Biological processes related to Linitis Plastica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:000758610.1PRSS1, PRSS2
2programmed cell deathGO:00125019.6CDH1, PKM
3extracellular matrix disassemblyGO:00226179.1CDH1, PRSS1, PRSS2
4extracellular matrix organizationGO:00301989.1CDH1, PRSS1, PRSS2
5response to organic substanceGO:00100339.0CDH1, PKM

Molecular functions related to Linitis Plastica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042529.6PRSS1, PRSS2

Sources for Linitis Plastica

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet