MCID: LPD008
MIFTS: 41

Lipid Metabolism Disorder malady

Metabolic diseases category

Aliases & Classifications for Lipid Metabolism Disorder

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Sources:
9Disease Ontology, 43Novoseek, 22GTR, 60UMLS, 33MeSH, 25ICD10
See all sources

Lipid Metabolism Disorder, Aliases & Descriptions:

Name: Lipid Metabolism Disorder 9
Fatty Acid Metabolism Disorder 9 22
Dyslipidemia 9 43
 
Lipid Metabolism Disorders 60
Dyslipidemias 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology9 DOID:3146
MeSH33 D008052
ICD1025 E71.3

Summaries for Lipid Metabolism Disorder

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Disease Ontology:9 An inherited metabolic disorder that involves the creation and degradation of lipids.

MalaCards based summary: Lipid Metabolism Disorder, also known as fatty acid metabolism disorder, is related to hypothyroidism and atherosclerosis. An important gene associated with Lipid Metabolism Disorder is ACAT1 (acetyl-CoA acetyltransferase 1), and among its related pathways are Selenium Pathway and FOXA1 transcription factor network. The compounds desogestrel and fructosamine have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and prostate, and related mouse phenotype liver/biliary system.

Related Diseases for Lipid Metabolism Disorder

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Diseases related to Lipid Metabolism Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1hypothyroidism30.5INS, APOB
2atherosclerosis30.5INS, APOB, LPL
3coronary artery disease30.4LPL, APOB
4hyperglycemia30.3INS, APOB, LPL
5lipodystrophy30.3LPL, APOB, INS
6glucose intolerance30.2INS, APOB, LPL
7fatty liver disease30.2INS, APOB, LPL
8hypertriglyceridemia30.1APOB, LPL
9hyperlipidemia type 330.1APOB, LPL
10obesity30.0LPL, APOB, INS
11hypoalphalipoproteinemia30.0APOB, LPL
12tangier disease30.0LPL, APOB
13nephrotic syndrome30.0LPL, APOB
14hyperuricemia30.0INS, APOB
15hyperinsulinism30.0LPL, APOB, INS
16kidney disease29.9LPL, APOB
17metabolic syndrome x29.9INS, LPL
18xanthomatosis29.8APOB, LPL
19proteinuria29.8APOB, INS
20vascular disease29.7INS, APOB, LPL
21chronic kidney failure29.7INS, APOB, LPL
22cystic fibrosis29.4LPL, INS
23artery disease10.4
24liver disease10.4
25hyperalphalipoproteinemia10.4APOB
26blindness10.3
27polycystic ovary syndrome10.3
28carnitine-acylcarnitine translocase deficiency10.2
29carnitine deficiency, systemic primary10.2
30acyl-coa dehydrogenase, short-chain, deficiency of10.2
31sjogren-larsson syndrome10.2
32peroxisomal acyl-coa oxidase deficiency10.2
33adrenoleukodystrophy10.2
34lchad deficiency10.2
353-hydroxyacyl-coa dehydrogenase deficiency10.2
36glutaric acidemia iic10.2
37succinyl coa:3-oxoacid coa transferase deficiency10.2
38vlcad deficiency10.2
39childhood-onset cerebral x-linked adrenoleukodystrophy10.2
40medium-chain acyl-coenzyme a dehydrogenase deficiency10.2
41adrenomyeloneuropathy10.2
42carnitine palmitoyltransferase i deficiency , muscle10.2
43lcad deficiency10.2
44neonatal adrenoleukodystrophy10.2
45acyl-coa dehydrogenase 9 deficiency10.2
46carnitine palmitoyl transferase ii deficiency, myopathic form10.2
47carnitine palmitoyl transferase ii deficiency, severe infantile form10.2
48carnitine palmitoyl transferase ii deficiency, neonatal form10.2
49transient neonatal multiple acyl-coa dehydrogenase deficiency10.2
50multiple acyl-coa dehydrogenation deficiency, mild type10.2

Graphical network of the top 20 diseases related to Lipid Metabolism Disorder:



Diseases related to lipid metabolism disorder

Symptoms for Lipid Metabolism Disorder

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Drugs & Therapeutics for Lipid Metabolism Disorder

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Drug clinical trials:

Search ClinicalTrials for Lipid Metabolism Disorder

Search NIH Clinical Center for Lipid Metabolism Disorder

Genetic Tests for Lipid Metabolism Disorder

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Genetic tests related to Lipid Metabolism Disorder:

id Genetic test Affiliating Genes
1 Disorder of Fatty Acid Metabolism22

Anatomical Context for Lipid Metabolism Disorder

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MalaCards organs/tissues related to Lipid Metabolism Disorder:

31
Heart, Kidney, Prostate

Animal Models for Lipid Metabolism Disorder or affiliated genes

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MGI Mouse Phenotypes related to Lipid Metabolism Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5LPL, APOB, INS

Publications for Lipid Metabolism Disorder

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Articles related to Lipid Metabolism Disorder:

(show all 21)
idTitleAuthorsYear
1
Yhhu981, a novel compound, stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob/ob mice. (25732571)
2015
2
Danqi Pill regulates lipid metabolism disorder induced by myocardial ischemia through FATP-CPTI pathway. (25885422)
2015
3
Angelica sinensis polysaccharide regulates glucose and lipid metabolism disorder in prediabetic and streptozotocin-induced diabetic mice through the elevation of glycogen levels and reduction of inflammatory factors. (25630053)
2015
4
L-Carnitine intake prevents irregular feeding-induced obesity and lipid metabolism disorder. (25445284)
2015
5
Ameliorating effect of mother tincture of Syzygium jambolanum on carbohydrate and lipid metabolic disorders in streptozotocin-induced diabetic rat: Homeopathic remedy. (23633838)
2013
6
Green tea extract containing a highly absorbent catechin prevents diet-induced lipid metabolism disorder. (24067358)
2013
7
Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy. (22213519)
2012
8
Abnormal barrier function in the pathogenesis of ichthyosis: therapeutic implications for lipid metabolic disorders. (22507046)
2012
9
Quercetin Protects against Cadmium-Induced Renal Uric Acid Transport System Alteration and Lipid Metabolism Disorder in Rats. (22690247)
2012
10
The model of rat lipid metabolism disorder induced by chronic stress accompanying high-fat-diet. (21871127)
2011
11
Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein. (21093950)
2011
12
Chanarin-Dorfman syndrome: clinical features of a rare lipid metabolism disorder. (19250403)
2009
13
Fat and cholesterol diet induced lipid metabolic disorders and insulin resistance in rabbit. (19301228)
2009
14
Carbohydrate and lipid metabolism disorders in obese children and adolescents]. (15858253)
2004
15
Interconnection between insulin resistance and lipid metabolism disorders in obese patients]. (12469622)
2002
16
Pharmacologic treatment of lipid metabolism disorders]. (9214849)
1996
17
The evaluation of a method for determining apolipoproteins as a sensitive indicator in assessing lipid metabolic disorder in a population at risk for essential arterial hypertension (EAHT)]. (9455355)
1995
18
Lipid metabolic disorders and lipid peroxidation in patients with the nephrotic syndrome]. (8079411)
1994
19
Relationship between lipid metabolism disorders and age of first manifestations of coronary heart disease]. (1509793)
1992
20
Pathophysiology and therapy of lipid metabolism disorders in kidney diseases]. (1921228)
1991
21
A lipid metabolic disorder: disseminated lipogranulomatosis; a syndrome with similarity to, and important difference from, Niemann-Pick and Hand-SchA1ller-Christian disease. (12975849)
1952

Variations for Lipid Metabolism Disorder

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Expression for genes affiliated with Lipid Metabolism Disorder

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Search GEO for disease gene expression data for Lipid Metabolism Disorder.

Pathways for genes affiliated with Lipid Metabolism Disorder

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Pathways related to Lipid Metabolism Disorder according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway36
9.3APOB, INS
2
Show member pathways
FOXA transcription factor networks36
9.3APOB, INS
3
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)36
Fatty Acid Beta Oxidation36
9.1ACAT1, LPL
4
Show member pathways
9.1ACAT1, LPL
5
Show member pathways
9.1LPL, INS
69.1INS, LPL
7
Show member pathways
9.0LPL, APOB
8
Show member pathways
9.0APOB, LPL
9
Show member pathways
9.0LPL, APOB
108.5LPL, APOB, INS
11
Show member pathways
8.0INS, APOB, LPL, ACAT1

Compounds for genes affiliated with Lipid Metabolism Disorder

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Compounds related to Lipid Metabolism Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1desogestrel43 1210.7APOB, INS
2fructosamine43 2410.7APOB, INS
3acipimox43 2810.7INS, APOB
4ezetimibe43 1210.7APOB, INS
5rosuvastatin43 49 28 1212.6INS, APOB
6thiazide439.5LPL, INS
7doxazosin43 1210.5LPL, INS
8thiazolidinedione439.5LPL, INS
9pluronic f127439.4APOB, LPL
10fenofibric acid43 2810.4LPL, APOB
11ritonavir43 49 1211.4INS, LPL
12ciprofibrate43 2810.4LPL, APOB
13retinyl palmitate43 2410.4LPL, APOB
14protamine439.4INS, LPL
15streptozotocin439.4LPL, INS
16xbai439.4LPL, APOB
17probucol43 1210.4APOB, LPL
18tocopherol439.4LPL, APOB
19cholesterol ester439.4APOB, LPL
20taurocholate439.3LPL, APOB
21uric acid43 2410.3INS, APOB
22dextran sulfate439.3LPL, APOB
23fluvastatin43 49 28 1212.3LPL, APOB
24myristic acid43 24 1211.2LPL, INS
25betacarotene439.2LPL, APOB
26phenylephrine43 28 24 1212.2LPL, APOB
27oleic acid43 28 24 1212.1APOB, LPL
28lovastatin43 49 59 28 1213.0LPL, APOB
29intralipid439.0LPL, APOB, INS
30orlistat43 59 1211.0LPL, APOB, INS
31starch439.0INS, APOB, LPL
32gemfibrozil28 43 1211.0LPL, APOB, INS
33niacin43 1210.0LPL, APOB, INS
34bezafibrate43 28 1210.9INS, APOB, LPL
35fenofibrate43 49 1210.9LPL, APOB, INS
36metformin43 49 1210.9LPL, APOB, INS
37triacylglycerol438.9INS, APOB, LPL
38pioglitazone28 43 49 1211.9LPL, APOB, INS
39carnitine438.9INS, APOB, LPL
40palmitate438.9INS, APOB, LPL
41rosiglitazone28 43 49 24 1212.9LPL, APOB, INS
42thyroxine43 249.9LPL, APOB, INS
43epinephrine43 24 1210.9INS, APOB, LPL
44fatty acid438.9INS, APOB, LPL
45lactate438.8LPL, APOB, INS
46testosterone43 59 24 1211.7INS, APOB, LPL
47pravastatin43 49 28 24 1212.7LPL, APOB
48dexamethasone43 49 28 1211.7INS, APOB, LPL
49cholesterol43 28 24 1211.4ACAT1, LPL, APOB, INS
50glutamate438.4LPL, APOB, INS

GO Terms for genes affiliated with Lipid Metabolism Disorder

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Cellular components related to Lipid Metabolism Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endosome lumenGO:00319049.4APOB, INS
2chylomicronGO:00426279.1LPL, APOB
3very-low-density lipoprotein particleGO:00343619.0LPL, APOB
4endoplasmic reticulum lumenGO:00057889.0APOB, INS
5extracellular regionGO:00055768.5LPL, APOB, INS
6extracellular spaceGO:00056158.4INS, APOB, LPL

Biological processes related to Lipid Metabolism Disorder according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cholesterol storageGO:00108869.2LPL, APOB
2positive regulation of macrophage derived foam cell differentiationGO:00107449.1LPL, APOB
3triglyceride catabolic processGO:00194339.0APOB, LPL
4phototransduction, visible lightGO:00076039.0LPL, APOB
5lipoprotein metabolic processGO:00421578.9LPL, APOB
6retinoid metabolic processGO:00015238.7LPL, APOB
7small molecule metabolic processGO:00442818.1ACAT1, LPL, APOB, INS

Molecular functions related to Lipid Metabolism Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.0LPL, APOB

Products for genes affiliated with Lipid Metabolism Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Lipid Metabolism Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet