MCID: LPD008
MIFTS: 48

Lipid Metabolism Disorder malady

Metabolic diseases category
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Summaries for Lipid Metabolism Disorder

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Wikipedia:65 Numerous genetic disorders are caused by errors in fatty acid metabolism. These disorders may be... more...

MalaCards based summary: Lipid Metabolism Disorder, also known as fatty acid metabolism disorder, is related to familial hypertriglyceridemia and nephrotic syndrome. An important gene associated with Lipid Metabolism Disorder is ACAT1 (acetyl-CoA acetyltransferase 1), and among its related pathways are Selenium Pathway and FOXA1 transcription factor network. The compounds desogestrel and fructosamine have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and kidney, and related mouse phenotype liver/biliary system.

Disease Ontology:8 An inhertited metabolic disorder that involves the creation and degradation of lipids.

Aliases & Classifications for Lipid Metabolism Disorder

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Lipid Metabolism Disorder, Aliases & Descriptions:

Name: Lipid Metabolism Disorder 8
Fatty Acid Metabolism Disorder 8 22 62
 
Lipid Metabolism Disorders 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology8 DOID:3146
MeSH34 D008052
ICD1025 E71.3

Related Diseases for Lipid Metabolism Disorder

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Diseases related to Lipid Metabolism Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1familial hypertriglyceridemia30.1APOB, LPL
2nephrotic syndrome30.0LPL, APOB
3insulin resistance30.0INS, APOB, LPL
4obesity29.9LPL, APOB, INS
5hypertension29.8LPL, APOB, INS
6adrenoleukodystrophy10.4
7hyperalphalipoproteinemia10.4APOB
8cpt ii deficiency, lethal neonatal10.3
9sjogren-larsson syndrome10.2
10systemic primary carnitine deficiency disease10.2
11peroxisomal acyl-coa oxidase deficiency10.2
12medium-chain acyl-coenzyme a dehydrogenase deficiency10.2
13short-chain acyl-coa dehydrogenase deficiency10.2
14very long-chain acyl-coenzyme a dehydrogenase deficiency10.2
15carnitine-acylcarnitine translocase deficiency10.2
16d-bifunctional protein deficiency10.2
17lcad deficiency10.2
18lchad deficiency10.2
19scot deficiency10.2
203-hydroxyacyl-coa dehydrogenase deficiency10.2
21myopathy due to cpt ii deficiency10.2
22cpt deficiency, hepatic, type ii10.2
23hmg-coa synthase-2 deficiency10.2
24peroxisome biogenesis disorder 11b10.2
25acad9 deficiency10.2
26glutaric acidemia iic10.2
27cpt deficiency, hepatic, type ia10.2
28transient neonatal multiple acyl-coa dehydrogenase deficiency10.2
29multiple acyl-coa dehydrogenation deficiency, mild type10.2
30multiple acyl-coa dehydrogenation deficiency, severe neonatal type10.2
31hyperuricemia10.1INS, APOB
32stroke, ischemic10.1INS, APOB
33hepatitis10.1
34ischemic heart disease10.1
35prostate cancer10.1
36hepatitis c10.1
37barth syndrome10.1
38kidney disease10.1
39prostatitis10.1
40steroid inherited metabolic disorder10.1
41sitosterolemia10.1
42lipogranulomatosis10.1
43hypothyroidism10.1INS, APOB
44metabolic syndrome x10.0INS, LPL
45morbid obesity10.0LPL, INS
46norum disease10.0LPL, APOB
47diabetic nephropathy10.0APOB, INS
48xanthomatosis10.0APOB, LPL
49hyperlipidemia type 310.0APOB, LPL
50abetalipoproteinemia10.0LPL, APOB

Graphical network of the top 20 diseases related to Lipid Metabolism Disorder:



Diseases related to lipid metabolism disorder

Symptoms for Lipid Metabolism Disorder

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Drugs & Therapeutics for Lipid Metabolism Disorder

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Drug clinical trials:

Search ClinicalTrials for Lipid Metabolism Disorder

Search NIH Clinical Center for Lipid Metabolism Disorder

Genetic Tests for Lipid Metabolism Disorder

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Genetic tests related to Lipid Metabolism Disorder:

id Genetic test Affiliating Genes
1 Disorder of Fatty Acid Metabolism22

Anatomical Context for Lipid Metabolism Disorder

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MalaCards organs/tissues related to Lipid Metabolism Disorder:

32
Liver, Heart, Kidney, Prostate

Animal Models for Lipid Metabolism Disorder or affiliated genes

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MGI Mouse Phenotypes related to Lipid Metabolism Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5LPL, APOB, INS

Publications for Lipid Metabolism Disorder

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Articles related to Lipid Metabolism Disorder:

(show all 18)
idTitleAuthorsYear
1
Ameliorating effect of mother tincture of Syzygium jambolanum on carbohydrate and lipid metabolic disorders in streptozotocin-induced diabetic rat: Homeopathic remedy. (23633838)
2013
2
Green tea extract containing a highly absorbent catechin prevents diet-induced lipid metabolism disorder. (24067358)
2013
3
Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy. (22213519)
2012
4
Abnormal barrier function in the pathogenesis of ichthyosis: therapeutic implications for lipid metabolic disorders. (22507046)
2012
5
Quercetin Protects against Cadmium-Induced Renal Uric Acid Transport System Alteration and Lipid Metabolism Disorder in Rats. (22690247)
2012
6
The model of rat lipid metabolism disorder induced by chronic stress accompanying high-fat-diet. (21871127)
2011
7
Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein. (21093950)
2011
8
Chanarin-Dorfman syndrome: clinical features of a rare lipid metabolism disorder. (19250403)
2009
9
Fat and cholesterol diet induced lipid metabolic disorders and insulin resistance in rabbit. (19301228)
2009
10
Carbohydrate and lipid metabolism disorders in obese children and adolescents]. (15858253)
2004
11
Interconnection between insulin resistance and lipid metabolism disorders in obese patients]. (12469622)
2002
12
Pharmacologic treatment of lipid metabolism disorders]. (9214849)
1996
13
The evaluation of a method for determining apolipoproteins as a sensitive indicator in assessing lipid metabolic disorder in a population at risk for essential arterial hypertension (EAHT)]. (9455355)
1995
14
Lipid metabolic disorders and lipid peroxidation in patients with the nephrotic syndrome]. (8079411)
1994
15
Relationship between lipid metabolism disorders and age of first manifestations of coronary heart disease]. (1509793)
1992
16
Pathophysiology and therapy of lipid metabolism disorders in kidney diseases]. (1921228)
1991
17
Restriction polymorphism in patients with lipid metabolism disorders and ischemic heart disease]. (1979835)
1990
18
A lipid metabolic disorder: disseminated lipogranulomatosis; a syndrome with similarity to, and important difference from, Niemann-Pick and Hand-SchA1ller-Christian disease. (12975849)
1952

Variations for Lipid Metabolism Disorder

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Expression for genes affiliated with Lipid Metabolism Disorder

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Expression patterns in normal tissues for genes affiliated with Lipid Metabolism Disorder

Search GEO for disease gene expression data for Lipid Metabolism Disorder.

Pathways for genes affiliated with Lipid Metabolism Disorder

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Pathways related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway37
9.3APOB, INS
2
Show member pathways
FOXA transcription factor networks37
9.3APOB, INS
39.3APOB, INS
4
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)37
Fatty Acid Beta Oxidation37
9.1ACAT1, LPL
5
Show member pathways
9.1ACAT1, LPL
6
Show member pathways
9.1LPL, INS
79.1INS, LPL
8
Show member pathways
9.0LPL, APOB
9
Show member pathways
9.0APOB, LPL
10
Show member pathways
9.0LPL, APOB
118.5LPL, APOB, INS
12
Show member pathways
8.0INS, APOB, LPL, ACAT1

Compounds for genes affiliated with Lipid Metabolism Disorder

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Compounds related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1desogestrel44 1110.7APOB, INS
2fructosamine44 2410.7APOB, INS
3acipimox44 2810.7INS, APOB
4ezetimibe44 1110.7APOB, INS
5rosuvastatin44 50 28 1112.6INS, APOB
6thiazide449.5LPL, INS
7doxazosin44 1110.5LPL, INS
8thiazolidinedione449.5LPL, INS
9pluronic f127449.4APOB, LPL
10fenofibric acid44 2810.4LPL, APOB
11ritonavir44 50 1111.4INS, LPL
12ciprofibrate44 2810.4LPL, APOB
13retinyl palmitate44 2410.4LPL, APOB
14protamine449.4INS, LPL
15streptozotocin449.4LPL, INS
16xbai449.4LPL, APOB
17probucol44 1110.4APOB, LPL
18tocopherol449.4LPL, APOB
19cholesterol ester449.4APOB, LPL
20taurocholate449.3LPL, APOB
21uric acid44 2410.3INS, APOB
22dextran sulfate449.3LPL, APOB
23fluvastatin44 50 28 1112.3LPL, APOB
24myristic acid44 24 1111.2LPL, INS
25betacarotene449.2LPL, APOB
26phenylephrine44 28 24 1112.2LPL, APOB
27oleic acid44 28 24 1112.1APOB, LPL
28lovastatin44 50 61 28 1113.0LPL, APOB
29intralipid449.0LPL, APOB, INS
30orlistat44 61 1111.0LPL, APOB, INS
31starch449.0INS, APOB, LPL
32gemfibrozil28 44 1111.0LPL, APOB, INS
33niacin44 1110.0LPL, APOB, INS
34bezafibrate44 28 1110.9INS, APOB, LPL
35fenofibrate44 50 1110.9LPL, APOB, INS
36metformin44 50 1110.9LPL, APOB, INS
37triacylglycerol448.9INS, APOB, LPL
38pioglitazone28 44 50 1111.9LPL, APOB, INS
39carnitine448.9INS, APOB, LPL
40palmitate448.9INS, APOB, LPL
41rosiglitazone28 44 50 24 1112.9LPL, APOB, INS
42thyroxine44 249.9LPL, APOB, INS
43epinephrine44 24 1110.9INS, APOB, LPL
44fatty acid448.9INS, APOB, LPL
45lactate448.8LPL, APOB, INS
46testosterone44 61 24 1111.7INS, APOB, LPL
47pravastatin44 50 28 24 1112.7LPL, APOB
48dexamethasone44 50 28 1111.7INS, APOB, LPL
49cholesterol44 28 24 1111.4ACAT1, LPL, APOB, INS
50glutamate448.4LPL, APOB, INS

GO Terms for genes affiliated with Lipid Metabolism Disorder

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Cellular components related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome lumenGO:0319049.4APOB, INS
2chylomicronGO:0426279.1LPL, APOB
3very-low-density lipoprotein particleGO:0343619.0LPL, APOB
4endoplasmic reticulum lumenGO:0057889.0APOB, INS
5extracellular regionGO:0055768.5LPL, APOB, INS
6extracellular spaceGO:0056158.4INS, APOB, LPL

Biological processes related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cholesterol storageGO:0108869.2LPL, APOB
2positive regulation of macrophage derived foam cell differentiationGO:0107449.1LPL, APOB
3triglyceride catabolic processGO:0194339.0APOB, LPL
4phototransduction, visible lightGO:0076039.0LPL, APOB
5lipoprotein metabolic processGO:0421578.9LPL, APOB
6retinoid metabolic processGO:0015238.7LPL, APOB
7small molecule metabolic processGO:0442818.1ACAT1, LPL, APOB, INS

Molecular functions related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.0LPL, APOB

Products for genes affiliated with Lipid Metabolism Disorder

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  • Antibodies
  • Proteins
  • Lysates

Sources for Lipid Metabolism Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet