MCID: LPD008
MIFTS: 50

Lipid Metabolism Disorder malady

Metabolic diseases category

Summaries for Lipid Metabolism Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Numerous genetic disorders are caused by errors in fatty acid metabolism. These disorders may be... more...

MalaCards: Lipid Metabolism Disorder, also known as fatty acid metabolism disorder, is related to obesity and hepatitis c. An important gene associated with Lipid Metabolism Disorder is ACAT1 (acetyl-CoA acetyltransferase 1), and among its related pathways are Fatty Acid Beta Oxidation and FOXA1 transcription factor network. The compounds palmitate and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and brain, and related mouse phenotype liver/biliary system.

Disease Ontology:8 An inhertited metabolic disorder that involves the creation and degradation of lipids.

Aliases & Classifications for Lipid Metabolism Disorder

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8Disease Ontology, 22GTR, 60UMLS, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

lipid metabolism disorder 8
fatty acid metabolism disorder 8 22
lipid metabolism disorders 60


External Ids:

Disease Ontology8 DOID:3146
MeSH34 D008052
ICD1025 E71.3

Related Diseases for Lipid Metabolism Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lipid Metabolism Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.2INS, LPL, APOB, APOA1
2hepatitis c30.0LPL
3nephrotic syndrome30.0LPL, APOB, APOA1
4familial hypertriglyceridemia30.0APOA1, APOB, LPL
5ischemic heart disease30.0APOA1, APOB, LPL
6hypertension30.0APOA1, APOB, LPL, INS
7essential hypertension30.0APOA1, APOB, HLA-G, LPL, INS
8adrenoleukodystrophy10.4
93-hydroxyacyl-coa dehydrogenase deficiency10.3
10myopathy due to cpt ii deficiency10.3
11carbohydrate metabolic disorder10.2
12systemic primary carnitine deficiency disease10.2
13sjogren-larsson syndrome10.2
14peroxisomal acyl-coa oxidase deficiency10.2
15medium-chain acyl-coenzyme a dehydrogenase deficiency10.2
16short-chain acyl-coa dehydrogenase deficiency10.2
17very long-chain acyl-coenzyme a dehydrogenase deficiency10.2
18lcad deficiency10.2
19carnitine-acylcarnitine translocase deficiency10.2
20d-bifunctional protein deficiency10.2
21scot deficiency10.2
22lchad deficiency10.2
23cpt deficiency, hepatic, type ii10.2
24cpt ii deficiency, lethal neonatal10.2
25hmg-coa synthase-2 deficiency10.2
26acad9 deficiency10.2
27glutaric acidemia iic10.2
28cpt deficiency, hepatic, type ia10.2
29peroxisome biogenesis disorder 2b10.2
30riboflavin deficiency10.2
31niemann-pick disease10.0
32barth syndrome10.0
33hepatitis10.0
34kidney disease10.0
35prostate cancer10.0
36prostatitis10.0
37steroid inherited metabolic disorder10.0
38sitosterolemia10.0
39growth hormone deficiency10.0INS
40acromegaly10.0INS
41amenorrhea10.0INS
42chylomicron retention disease10.0APOB
43myositis10.0HLA-G
44psoriasis10.0HLA-G
45lipoprotein lipase deficiency10.0LPL
46blindness10.0INS
47uremia10.0LPL
48dementia10.0LPL
49hyperthyroidism10.0INS
50fatty liver disease10.0INS

Graphical network of the top 20 diseases related to Lipid Metabolism Disorder:



Diseases related to lipid metabolism disorder

Clinical Features for Lipid Metabolism Disorder

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Drugs & Therapeutics for Lipid Metabolism Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Lipid Metabolism Disorder

Drug clinical trials:

Search ClinicalTrials for Lipid Metabolism Disorder

Search NIH Clinical Center for Lipid Metabolism Disorder

Search CenterWatch for Lipid Metabolism Disorder

Genetic Tests for Lipid Metabolism Disorder

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22GTR
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Genetic tests related to Lipid Metabolism Disorder:

id Genetic test Affiliating Genes
1 Disorder of Fatty Acid Metabolism22

Anatomical Context for Lipid Metabolism Disorder

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32MalaCards
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MalaCards organs/tissues related to Lipid Metabolism Disorder:

32
Liver, Heart, Brain, Kidney, Prostate

Animal Models for Lipid Metabolism Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lipid Metabolism Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.0INS, LPL, APOB, APOA1

Publications for Lipid Metabolism Disorder

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50PubMed
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Articles related to Lipid Metabolism Disorder:

(show all 42)
idTitleAuthorsYear
1
Hypertensive pregnancy disorders as a risk factor for future cardiovascular and metabolic disorders (Tehran Lipid and Glucose Study). (23438323)
2013
2
Dietary spices as beneficial modulators of lipid profile in conditions of metabolic disorders and diseases. (23364205)
2013
3
Ameliorating effect of mother tincture of Syzygium jambolanum on carbohydrate and lipid metabolic disorders in streptozotocin-induced diabetic rat: Homeopathic remedy. (23633838)
2013
4
Green tea extract containing a highly absorbent catechin prevents diet-induced lipid metabolism disorder. (24067358)
2013
5
Ichthyosis prematurity syndrome: clinical evaluation of 17 families with a rare disorder of lipid metabolism. (21856041)
2012
6
Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy. (22213519)
2012
7
Abnormal barrier function in the pathogenesis of ichthyosis: therapeutic implications for lipid metabolic disorders. (22507046)
2012
8
Quercetin Protects against Cadmium-Induced Renal Uric Acid Transport System Alteration and Lipid Metabolism Disorder in Rats. (22690247)
2012
9
Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review. (23243452)
2012
10
The model of rat lipid metabolism disorder induced by chronic stress accompanying high-fat-diet. (21871127)
2011
11
FABP2 gene polymorphism and metabolic disorder of lipids in the middle aged and aged population]. (21861348)
2011
12
Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein. (21093950)
2011
13
Disorders of lipid metabolism in patients with cholelithiasis and gallbladder cholesterosis depending on apolipoprotein E genotype]. (20919569)
2010
14
Association of the PPARgamma2 gene Pro12Ala variant with primary hypertension and metabolic lipid disorders in Han Chinese of Inner Mongolia. (20623456)
2010
15
Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders. (19622391)
2009
16
Chanarin-Dorfman syndrome: clinical features of a rare lipid metabolism disorder. (19250403)
2009
17
Fat and cholesterol diet induced lipid metabolic disorders and insulin resistance in rabbit. (19301228)
2009
18
Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism. (18245815)
2008
19
Altered lipid metabolism in brain injury and disorders. (18751914)
2008
20
Primary and secondary disorders of lipid metabolism in pediatrics. (18317444)
2008
21
Wilson disease: not just a copper disorder. Analysis of a Wilson disease model demonstrates the link between copper and lipid metabolism. (18000558)
2007
22
Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism. (16390683)
2005
23
Carbohydrate and lipid metabolism disorders in obese children and adolescents]. (15858253)
2004
24
Musculoskeletal features of disorders of lipid metabolism and multicentric reticulohistiocytosis. (14673393)
2004
25
Characteristics of lipid profile in blood plasma of patients with metabolic syndrome and manifest disorder of carbohydrate metabolism]. (14669600)
2003
26
Interconnection between insulin resistance and lipid metabolism disorders in obese patients]. (12469622)
2002
27
Neutral lipid storage disease: a genetic disorder with abnormalities in the regulation of phospholipid metabolism. (9469583)
1998
28
Interferon alpha induces disorder of lipid metabolism by lowering postheparin lipases and cholesteryl ester transfer protein activities in patients with chronic hepatitis C. (9185775)
1997
29
Pharmacologic treatment of lipid metabolism disorders]. (9214849)
1996
30
Disorders of lipid metabolism in insulin resistance]. (7713475)
1995
31
The evaluation of a method for determining apolipoproteins as a sensitive indicator in assessing lipid metabolic disorder in a population at risk for essential arterial hypertension (EAHT)]. (9455355)
1995
32
Lipid metabolic disorders and lipid peroxidation in patients with the nephrotic syndrome]. (8079411)
1994
33
Disorders of carbohydrate and lipid metabolism in veterans with paraplegia or quadriplegia: a model of premature aging. (8201966)
1994
34
HMG-CoA reductase inhibitors in therapy of disorders of lipid metabolism]. (8106206)
1993
35
Activity of selected proteinase inhibitors in patients with disorders of lipid metabolism]. (1384011)
1992
36
Relationship between lipid metabolism disorders and age of first manifestations of coronary heart disease]. (1509793)
1992
37
Pathophysiology and therapy of lipid metabolism disorders in kidney diseases]. (1921228)
1991
38
The cornea and disorders of lipid metabolism. (1925941)
1991
39
Restriction polymorphism in patients with lipid metabolism disorders and ischemic heart disease]. (1979835)
1990
40
Neutral-lipid storage disease: a new disorder of lipid metabolism. (1139147)
1975
41
Bassen-Kornweig syndrome. Neuromuscular disorder resembling Friedreich's ataxia associated with retinitis pigmentosa, acanthocytosis, steatorrhea, and an abnormality of lipid metabolism. (13909703)
1961
42
A lipid metabolic disorder: disseminated lipogranulomatosis; a syndrome with similarity to, and important difference from, Niemann-Pick and Hand-SchA1ller-Christian disease. (12975849)
1952

Genetic Variations for Lipid Metabolism Disorder

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Expression for genes affiliated with Lipid Metabolism Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipid Metabolism Disorder

Search GEO for disease gene expression data for Lipid Metabolism Disorder.

Pathways for genes affiliated with Lipid Metabolism Disorder

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 12EMD Millipore, 49PharmGKB
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Compounds for genes affiliated with Lipid Metabolism Disorder

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB
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Compounds related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1palmitate4410.4INS
2alpha tocopherol4410.1LPL
3pluronic f127449.5APOB, LPL
4polyethylene glycol 6000449.5APOA1, APOB
5maxepa449.5APOB, APOA1
6lynestrenol449.5APOA1, APOB
7colestipol449.4APOB, APOA1
8sodium oleate449.3LPL, APOA1
9trioleoylglycerol449.3LPL, APOA1
10campesterol44 2410.3APOB, APOA1
11orlistat44 59 1111.2LPL, APOB, INS
12starch449.2INS, LPL, APOB
13desogestrel44 1110.0APOB, INS, APOA1
14fructosamine44 2410.0APOA1, APOB, INS
15acipimox44 2810.0INS, APOB, APOA1
16ezetimibe44 1110.0INS, APOB, APOA1
17rosuvastatin44 49 28 1112.0APOB, APOA1, INS
18fenofibric acid44 289.9APOA1, APOB, LPL
19stavudine44 119.9LPL, APOA1
20ciprofibrate44 289.9APOB, APOA1, LPL
21rosiglitazone44 49 28 11 2412.9APOB, LPL, INS
22retinyl palmitate44 249.9APOA1, LPL, APOB
23doxazosin44 119.9LPL, APOA1, INS
24probucol44 119.9APOB, LPL, APOA1
25tocopherol448.9APOB, APOA1, LPL
26cholesterol ester448.9APOA1, APOB, LPL
27taurocholate448.9APOA1, LPL, APOB
28dextran sulfate448.8APOB, LPL, APOA1
29gestodene44 119.8APOA1, APOB
30fluvastatin44 49 28 1111.8LPL, APOA1, APOB
31lovastatin44 49 59 28 1112.8APOA1, LPL, APOB
32atorvastatin44 49 28 11 2412.7APOB, APOA1, LPL
33simvastatin44 49 59 28 11 2413.6LPL, APOA1, APOB
34phosphatidylcholine448.5APOA1, LPL, APOB
35intralipid448.4APOA1, APOB, INS, LPL
36gemfibrozil44 28 1110.4INS, LPL, APOB, APOA1
37niacin44 119.4INS, LPL, APOA1, APOB
38bezafibrate44 28 1110.4LPL, APOB, APOA1, INS
39fenofibrate44 49 1110.4INS, LPL, APOA1, APOB
40metformin44 49 1110.4APOA1, LPL, APOB, INS
41triacylglycerol448.4APOA1, APOB, LPL, INS
42pioglitazone44 49 28 1111.4APOA1, INS, LPL, APOB
43carnitine448.4APOB, LPL, APOA1, INS
44thyroxine44 249.4LPL, INS, APOA1, APOB
45creatinine448.4APOB, APOA1, INS, HLA-G
46testosterone44 59 11 2411.0APOA1, LPL, INS, APOB
47lactate447.9APOA1, HLA-G, LPL, INS, APOB
48dexamethasone44 49 28 1110.9HLA-G, LPL, APOB, INS, APOA1
49lipid447.8APOB, LPL, HLA-G, APOA1, INS
50cholesterol44 28 11 2410.6APOA1, HLA-G, LPL, INS, APOB, ACAT1

GO Terms for genes affiliated with Lipid Metabolism Disorder

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16Gene Ontology
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Cellular components related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome lumenGO:0319049.5APOB, INS
2chylomicronGO:0426279.3LPL, APOB
3secretory granule lumenGO:0347749.2APOA1, INS
4endocytic vesicle lumenGO:0716828.8APOB, APOA1
5very-low-density lipoprotein particleGO:0343618.7LPL, APOA1, APOB
6endoplasmic reticulum lumenGO:0057888.5APOB, INS, APOA1
7extracellular spaceGO:0056158.0APOA1, APOB, LPL, INS

Biological processes related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cholesterol storageGO:0108869.5APOB, LPL
2positive regulation of macrophage derived foam cell differentiationGO:0107449.4APOB, LPL
3lipoprotein biosynthetic processGO:0421589.4APOB, APOA1
4triglyceride catabolic processGO:0194339.3APOB, LPL
5cholesterol transportGO:0303019.3APOA1, APOB
6cholesterol metabolic processGO:0082039.1APOA1, APOB
7triglyceride homeostasisGO:0703289.1LPL, APOA1
8cholesterol effluxGO:0333449.0APOA1, APOB
9cholesterol homeostasisGO:0426328.8APOB, APOA1
10lipoprotein metabolic processGO:0421578.8APOA1, APOB, LPL
11retinoid metabolic processGO:0015238.8LPL, APOB, APOA1
12phototransduction, visible lightGO:0076038.7LPL, APOA1, APOB
13small molecule metabolic processGO:0442817.8INS, LPL, APOB, APOA1, ACAT1

Molecular functions related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol transporter activityGO:0171278.8APOB, APOA1
2enzyme bindingGO:0198998.7ACAT1, APOB, APOA1

Products for genes affiliated with Lipid Metabolism Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lipid Metabolism Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet