MCID: LPD008
MIFTS: 41

Lipid Metabolism Disorder malady

Metabolic category

Summaries for Lipid Metabolism Disorder

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Numerous genetic disorders are caused by errors in fatty acid metabolism. These disorders may be... more...

MalaCards: Lipid Metabolism Disorder, also known as fatty acid metabolism disorder, is related to insulin resistance and hepatitis c. An important gene associated with Lipid Metabolism Disorder is ACAT1 (acetyl-CoA acetyltransferase 1), and among its related pathways are Fatty Acid Beta Oxidation and FOXA1 transcription factor network. The compounds palmitate and alpha tocopherol have been mentioned in the context of this disorder. Related mouse phenotype liver/biliary system.

Disease Ontology:8 An inhertited metabolic disorder that involves the creation and degradation of lipids.

Aliases & Classifications for Lipid Metabolism Disorder

Sources:
8Disease Ontology, 22GTR, 61UMLS, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Metabolic


Aliases & Descriptions:

lipid metabolism disorder 8
fatty acid metabolism disorder 8 22
lipid metabolism disorders 61


External Ids:

Disease Ontology8 DOID:3146
MeSH35 D008052
ICD1025 E71.3

Related Diseases for Lipid Metabolism Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Lipid Metabolism Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance30.3LPL, APOA1, APOB, INS
2hepatitis c30.1LPL
3familial hypertriglyceridemia30.0LPL, APOA1, APOB
4coronary heart disease30.0APOB, LPL, INS, APOA1
5lip disease10.4
6n syndrome10.2
7niemann-pick disease10.1
8barth syndrome10.1
9pick's disease10.1
10hepatitis d10.1
11hepatitis a10.1
12steroid inherited metabolic disorder10.1
13niemann–pick disease10.1
14sitosterolemia10.1
15lipogranulomatosis10.1
16growth hormone deficiency10.0INS
17acromegaly10.0INS
18amenorrhea10.0INS
19myositis10.0HLA-G
20chylomicron retention disease10.0APOB
21psoriasis10.0HLA-G
22lipoprotein lipase deficiency10.0LPL
23blindness10.0INS
24uremia10.0LPL
25dementia10.0LPL
26hyperthyroidism10.0INS
27fatty liver disease10.0INS
28pre-eclampsia10.0HLA-G
29eclampsia10.0HLA-G
30thromboembolism10.0APOA1
31complete lcat deficiency10.0APOA1
32hypopituitarism10.0INS
33infertility10.0INS, HLA-G
34hypothyroidism10.0INS, APOB
35hyperuricemia10.0APOB, INS
36xanthomatosis10.0APOB, LPL
37breast cancer10.0INS, HLA-G
38alzheimer's disease10.0APOB, INS
39morbid obesity10.0INS, LPL
40metabolic syndrome x10.0LPL, INS
41hepatitis b10.0APOA1
42hyperalphalipoproteinemia10.0APOA1, APOB
43polycystic ovary syndrome10.0APOA1, INS
44arcus senilis10.0APOB, APOA1
45familial combined hyperlipidemia10.0APOB, APOA1
46acute myocardial infarction10.0APOA1, APOB
47dilated cardiomyopathy10.0LPL
48peripheral vascular disease10.0APOA1, APOB
49myocardial infarction10.0APOB, APOA1
50hypobetalipoproteinemia10.0APOB, APOA1

Graphical network of the top 20 diseases related to Lipid Metabolism Disorder:



Diseases related to lipid metabolism disorder

Clinical Features for Lipid Metabolism Disorder

Drugs & Therapeutics for Lipid Metabolism Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Lipid Metabolism Disorder

Drug clinical trials:

Search ClinicalTrials for Lipid Metabolism Disorder

Search NIH Clinical Center for Lipid Metabolism Disorder

Search CenterWatch for Lipid Metabolism Disorder

Genetic Tests for Lipid Metabolism Disorder

Sources:
22GTR
See all sources

Genetic tests related to Lipid Metabolism Disorder:

id Genetic test Affiliating Genes
1 Disorder Of Fatty Acid Metabolism22

Anatomical Context for Lipid Metabolism Disorder

Animal Models for Lipid Metabolism Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Lipid Metabolism Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.0INS, LPL, APOB, APOA1

Publications for Lipid Metabolism Disorder

Sources:
51PubMed
See all sources

Articles related to Lipid Metabolism Disorder:

(show all 30)
idTitleAuthorsYear
1
Green tea extract containing a highly absorbent catechin prevents diet-induced lipid metabolism disorder. (24067358)
2013
2
Ichthyosis prematurity syndrome: clinical evaluation of 17 families with a rare disorder of lipid metabolism. (21856041)
2012
3
Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy. (22213519)
2012
4
Quercetin Protects against Cadmium-Induced Renal Uric Acid Transport System Alteration and Lipid Metabolism Disorder in Rats. (22690247)
2012
5
The model of rat lipid metabolism disorder induced by chronic stress accompanying high-fat-diet. (21871127)
2011
6
Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein. (21093950)
2011
7
Disorders of lipid metabolism in patients with cholelithiasis and gallbladder cholesterosis depending on apolipoprotein E genotype]. (20919569)
2010
8
Chanarin-Dorfman syndrome: clinical features of a rare lipid metabolism disorder. (19250403)
2009
9
Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism. (18245815)
2008
10
Altered lipid metabolism in brain injury and disorders. (18751914)
2008
11
Primary and secondary disorders of lipid metabolism in pediatrics. (18317444)
2008
12
Wilson disease: not just a copper disorder. Analysis of a Wilson disease model demonstrates the link between copper and lipid metabolism. (18000558)
2007
13
Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism. (16390683)
2005
14
Carbohydrate and lipid metabolism disorders in obese children and adolescents]. (15858253)
2004
15
Musculoskeletal features of disorders of lipid metabolism and multicentric reticulohistiocytosis. (14673393)
2004
16
Characteristics of lipid profile in blood plasma of patients with metabolic syndrome and manifest disorder of carbohydrate metabolism]. (14669600)
2003
17
Interconnection between insulin resistance and lipid metabolism disorders in obese patients]. (12469622)
2002
18
Neutral lipid storage disease: a genetic disorder with abnormalities in the regulation of phospholipid metabolism. (9469583)
1998
19
Interferon alpha induces disorder of lipid metabolism by lowering postheparin lipases and cholesteryl ester transfer protein activities in patients with chronic hepatitis C. (9185775)
1997
20
Pharmacologic treatment of lipid metabolism disorders]. (9214849)
1996
21
Disorders of lipid metabolism in insulin resistance]. (7713475)
1995
22
Disorders of carbohydrate and lipid metabolism in veterans with paraplegia or quadriplegia: a model of premature aging. (8201966)
1994
23
HMG-CoA reductase inhibitors in therapy of disorders of lipid metabolism]. (8106206)
1993
24
Activity of selected proteinase inhibitors in patients with disorders of lipid metabolism]. (1384011)
1992
25
Relationship between lipid metabolism disorders and age of first manifestations of coronary heart disease]. (1509793)
1992
26
Pathophysiology and therapy of lipid metabolism disorders in kidney diseases]. (1921228)
1991
27
The cornea and disorders of lipid metabolism. (1925941)
1991
28
Restriction polymorphism in patients with lipid metabolism disorders and ischemic heart disease]. (1979835)
1990
29
Neutral-lipid storage disease: a new disorder of lipid metabolism. (1139147)
1975
30
Bassen-Kornweig syndrome. Neuromuscular disorder resembling Friedreich's ataxia associated with retinitis pigmentosa, acanthocytosis, steatorrhea, and an abnormality of lipid metabolism. (13909703)
1961

Genetic Variations for Lipid Metabolism Disorder

Expression for genes affiliated with Lipid Metabolism Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lipid Metabolism Disorder

Search GEO for disease gene expression data for Lipid Metabolism Disorder.

Pathways for genes affiliated with Lipid Metabolism Disorder

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome, 12EMD Millipore, 50PharmGKB
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Compounds for genes affiliated with Lipid Metabolism Disorder

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB
See all sources

Compounds related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1palmitate4510.4INS
2alpha tocopherol4510.1LPL
3pluronic f127459.5LPL, APOB
4maxepa459.5APOB, APOA1
5polyethylene glycol 6000459.5APOB, APOA1
6lynestrenol459.5APOB, APOA1
7colestipol459.4APOA1, APOB
8sodium oleate459.3APOA1, LPL
9trioleoylglycerol459.3LPL, APOA1
10campesterol45 2410.3APOB, APOA1
11orlistat45 60 1111.2APOB, LPL, INS
12starch459.2APOB, LPL, INS
13desogestrel45 1110.0INS, APOB, APOA1
14fructosamine45 2410.0APOA1, APOB, INS
15acipimox45 2910.0INS, APOB, APOA1
16ezetimibe45 1110.0APOA1, APOB, INS
17rosuvastatin45 50 29 1112.0APOA1, APOB, INS
18fenofibric acid45 299.9APOA1, APOB, LPL
19stavudine45 119.9LPL, APOA1
20ciprofibrate45 299.9LPL, APOB, APOA1
21rosiglitazone45 50 29 11 2412.9APOB, LPL, INS
22retinyl palmitate45 249.9LPL, APOB, APOA1
23doxazosin45 119.9APOA1, LPL, INS
24probucol45 119.9LPL, APOB, APOA1
25tocopherol458.9LPL, APOB, APOA1
26cholesterol ester458.9APOA1, APOB, LPL
27taurocholate458.9APOA1, APOB, LPL
28dextran sulfate458.8APOA1, APOB, LPL
29gestodene45 119.8APOB, APOA1
30fluvastatin45 50 29 1111.8LPL, APOB, APOA1
31lovastatin45 50 60 29 1112.8APOA1, APOB, LPL
32atorvastatin45 50 29 11 2412.7APOA1, APOB, LPL
33simvastatin45 50 60 29 11 2413.6LPL, APOB, APOA1
34phosphatidylcholine458.5LPL, APOB, APOA1
35intralipid458.4INS, LPL, APOB, APOA1
36gemfibrozil45 29 1110.4APOA1, APOB, LPL, INS
37niacin45 119.4APOA1, APOB, LPL, INS
38bezafibrate45 29 1110.4INS, LPL, APOB, APOA1
39fenofibrate45 50 1110.4INS, LPL, APOB, APOA1
40metformin45 50 1110.4APOA1, APOB, LPL, INS
41triacylglycerol458.4APOA1, APOB, LPL, INS
42pioglitazone45 50 29 1111.4INS, LPL, APOB, APOA1
43carnitine458.4INS, LPL, APOB, APOA1
44thyroxine45 249.4INS, LPL, APOB, APOA1
45creatinine458.4INS, HLA-G, APOB, APOA1
46testosterone45 60 11 2411.0APOA1, APOB, LPL, INS
47lactate457.9APOA1, APOB, HLA-G, LPL, INS
48dexamethasone45 50 29 1110.9APOA1, APOB, HLA-G, LPL, INS
49lipid457.8APOA1, APOB, HLA-G, LPL, INS
50cholesterol45 29 11 2410.6APOA1, APOB, HLA-G, LPL, INS, ACAT1

GO Terms for genes affiliated with Lipid Metabolism Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome lumenGO:0319049.5INS, APOB
2chylomicronGO:0426279.4APOB, LPL
3secretory granule lumenGO:0347749.1APOA1, INS
4endocytic vesicle lumenGO:0716828.8APOB, APOA1
5very-low-density lipoprotein particleGO:0343618.7LPL, APOB, APOA1
6endoplasmic reticulum lumenGO:0057888.5APOA1, APOB, INS
7extracellular spaceGO:0056158.0INS, LPL, APOB, APOA1

Biological processes related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cholesterol storageGO:0108869.5LPL, APOB
2positive regulation of macrophage derived foam cell differentiationGO:0107449.4LPL, APOB
3lipoprotein biosynthetic processGO:0421589.4APOA1, APOB
4triglyceride catabolic processGO:0194339.3APOB, LPL
5cholesterol transportGO:0303019.3APOB, APOA1
6cholesterol metabolic processGO:0082039.1APOB, APOA1
7triglyceride homeostasisGO:0703289.1APOA1, LPL
8cholesterol effluxGO:0333449.0APOB, APOA1
9cholesterol homeostasisGO:0426328.8APOB, APOA1
10lipoprotein metabolic processGO:0421578.8LPL, APOB, APOA1
11retinoid metabolic processGO:0015238.8LPL, APOB, APOA1
12phototransduction, visible lightGO:0076038.7LPL, APOB, APOA1
13small molecule metabolic processGO:0442817.8APOA1, APOB, LPL, INS, ACAT1

Molecular functions related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol transporter activityGO:0171278.8APOB, APOA1
2enzyme bindingGO:0198998.7ACAT1, APOB, APOA1

Products for genes affiliated with Lipid Metabolism Disorder

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lipid Metabolism Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet