MCID: LPD008
MIFTS: 45

Lipid Metabolism Disorder malady

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Summaries for Lipid Metabolism Disorder

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Numerous genetic disorders are caused by errors in fatty acid metabolism. These disorders may be... more...

MalaCards: Lipid Metabolism Disorder, also known as fatty acid metabolism disorder, is related to insulin resistance and obesity. An important gene associated with Lipid Metabolism Disorder is ACAT1 (acetyl-CoA acetyltransferase 1), and among its related pathways are Selenium Pathway and FOXA1 transcription factor network. The compounds desogestrel and fructosamine have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and kidney, and related mouse phenotype liver/biliary system.

Disease Ontology:8 An inhertited metabolic disorder that involves the creation and degradation of lipids.

Aliases & Classifications for Lipid Metabolism Disorder

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8Disease Ontology, 22GTR, 62UMLS, 35MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

lipid metabolism disorder 8
fatty acid metabolism disorder 8 22
lipid metabolism disorders 62


External Ids:

Disease Ontology8 DOID:3146
MeSH35 D008052
ICD1025 E71.3

Related Diseases for Lipid Metabolism Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Lipid Metabolism Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance30.2INS, APOB, LPL
2obesity30.2LPL, APOB, INS
3familial hypertriglyceridemia30.1APOB, LPL
4nephrotic syndrome30.1LPL, APOB
5hypertension30.0LPL, APOB, INS
6adrenoleukodystrophy10.4
73-hydroxyacyl-coa dehydrogenase deficiency10.3
8myopathy due to cpt ii deficiency10.3
9peroxisomal acyl-coa oxidase deficiency10.2
10systemic primary carnitine deficiency disease10.2
11sjogren-larsson syndrome10.2
12medium-chain acyl-coenzyme a dehydrogenase deficiency10.2
13short-chain acyl-coa dehydrogenase deficiency10.2
14very long-chain acyl-coenzyme a dehydrogenase deficiency10.2
15carnitine-acylcarnitine translocase deficiency10.2
16d-bifunctional protein deficiency10.2
17lcad deficiency10.2
18lchad deficiency10.2
19scot deficiency10.2
20cpt deficiency, hepatic, type ii10.2
21cpt ii deficiency, lethal neonatal10.2
22hmg-coa synthase-2 deficiency10.2
23acad9 deficiency10.2
24glutaric acidemia iic10.2
25cpt deficiency, hepatic, type ia10.2
26peroxisome biogenesis disorder 2b10.2
27riboflavin deficiency10.2
28multiple acyl-coa dehydrogenation deficiency, mild type10.2
29multiple acyl-coa dehydrogenation deficiency, severe neonatal type10.2
30hyperalphalipoproteinemia10.1APOB
31hepatitis c10.0
32barth syndrome10.0
33hepatitis10.0
34kidney disease10.0
35prostate cancer10.0
36prostatitis10.0
37steroid inherited metabolic disorder10.0
38sitosterolemia10.0
39lipogranulomatosis10.0
40hyperuricemia10.0INS, APOB
41stroke, ischemic10.0INS, APOB
42hypothyroidism10.0INS, APOB
43metabolic syndrome x10.0INS, LPL
44morbid obesity10.0LPL, INS
45norum disease10.0LPL, APOB
46diabetic nephropathy10.0APOB, INS
47xanthomatosis10.0APOB, LPL
48hyperlipidemia type 310.0APOB, LPL
49abetalipoproteinemia10.0LPL, APOB
50proteinuria10.0APOB, INS

Graphical network of the top 20 diseases related to Lipid Metabolism Disorder:



Diseases related to lipid metabolism disorder

Symptoms for Lipid Metabolism Disorder

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Drugs & Therapeutics for Lipid Metabolism Disorder

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Lipid Metabolism Disorder

Search NIH Clinical Center for Lipid Metabolism Disorder

Genetic Tests for Lipid Metabolism Disorder

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22GTR
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Genetic tests related to Lipid Metabolism Disorder:

id Genetic test Affiliating Genes
1 Disorder of Fatty Acid Metabolism22

Anatomical Context for Lipid Metabolism Disorder

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33MalaCards
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MalaCards organs/tissues related to Lipid Metabolism Disorder:

33
Liver, Heart, Kidney, Prostate

Animal Models for Lipid Metabolism Disorder or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Lipid Metabolism Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5LPL, APOB, INS

Publications for Lipid Metabolism Disorder

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52PubMed
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Articles related to Lipid Metabolism Disorder:

(show all 18)
idTitleAuthorsYear
1
Ameliorating effect of mother tincture of Syzygium jambolanum on carbohydrate and lipid metabolic disorders in streptozotocin-induced diabetic rat: Homeopathic remedy. (23633838)
2013
2
Green tea extract containing a highly absorbent catechin prevents diet-induced lipid metabolism disorder. (24067358)
2013
3
Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy. (22213519)
2012
4
Abnormal barrier function in the pathogenesis of ichthyosis: therapeutic implications for lipid metabolic disorders. (22507046)
2012
5
Quercetin Protects against Cadmium-Induced Renal Uric Acid Transport System Alteration and Lipid Metabolism Disorder in Rats. (22690247)
2012
6
The model of rat lipid metabolism disorder induced by chronic stress accompanying high-fat-diet. (21871127)
2011
7
Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein. (21093950)
2011
8
Chanarin-Dorfman syndrome: clinical features of a rare lipid metabolism disorder. (19250403)
2009
9
Fat and cholesterol diet induced lipid metabolic disorders and insulin resistance in rabbit. (19301228)
2009
10
Carbohydrate and lipid metabolism disorders in obese children and adolescents]. (15858253)
2004
11
Interconnection between insulin resistance and lipid metabolism disorders in obese patients]. (12469622)
2002
12
Pharmacologic treatment of lipid metabolism disorders]. (9214849)
1996
13
The evaluation of a method for determining apolipoproteins as a sensitive indicator in assessing lipid metabolic disorder in a population at risk for essential arterial hypertension (EAHT)]. (9455355)
1995
14
Lipid metabolic disorders and lipid peroxidation in patients with the nephrotic syndrome]. (8079411)
1994
15
Relationship between lipid metabolism disorders and age of first manifestations of coronary heart disease]. (1509793)
1992
16
Pathophysiology and therapy of lipid metabolism disorders in kidney diseases]. (1921228)
1991
17
Restriction polymorphism in patients with lipid metabolism disorders and ischemic heart disease]. (1979835)
1990
18
A lipid metabolic disorder: disseminated lipogranulomatosis; a syndrome with similarity to, and important difference from, Niemann-Pick and Hand-SchA1ller-Christian disease. (12975849)
1952

Variations for Lipid Metabolism Disorder

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Expression for genes affiliated with Lipid Metabolism Disorder

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipid Metabolism Disorder

Search GEO for disease gene expression data for Lipid Metabolism Disorder.

Pathways for genes affiliated with Lipid Metabolism Disorder

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Sources:
50PathCards, 38NCBI BioSystems Database, 12EMD Millipore, 55Reactome, 51PharmGKB, 30KEGG
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Pathways related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway38
9.3APOB, INS
2
Show member pathways
FOXA transcription factor networks38
9.3APOB, INS
39.3APOB, INS
4
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)38
Fatty Acid Beta Oxidation38
9.1ACAT1, LPL
5
Show member pathways
9.1ACAT1, LPL
6
Show member pathways
9.1LPL, INS
79.1INS, LPL
8
Show member pathways
9.0LPL, APOB
9
Show member pathways
9.0APOB, LPL
10
Show member pathways
9.0LPL, APOB
118.5LPL, APOB, INS
12
Show member pathways
8.0INS, APOB, LPL, ACAT1

Compounds for genes affiliated with Lipid Metabolism Disorder

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45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1desogestrel45 1110.7APOB, INS
2fructosamine45 2410.7INS, APOB
3acipimox45 2910.7APOB, INS
4ezetimibe45 1110.7APOB, INS
5rosuvastatin45 51 29 1112.7INS, APOB
6thiazide459.5LPL, INS
7doxazosin45 1110.5LPL, INS
8thiazolidinedione459.5INS, LPL
9pluronic f127459.4APOB, LPL
10fenofibric acid45 2910.4APOB, LPL
11ritonavir45 51 1111.4INS, LPL
12ciprofibrate45 2910.4APOB, LPL
13retinyl palmitate45 2410.4LPL, APOB
14protamine459.4INS, LPL
15xbai459.4LPL, APOB
16streptozotocin459.4LPL, INS
17probucol45 1110.4LPL, APOB
18tocopherol459.4APOB, LPL
19cholesterol ester459.3LPL, APOB
20taurocholate459.3LPL, APOB
21uric acid45 2410.3INS, APOB
22dextran sulfate459.3LPL, APOB
23fluvastatin45 51 29 1112.3LPL, APOB
24myristic acid45 24 1111.2INS, LPL
25betacarotene459.2APOB, LPL
26phenylephrine45 29 24 1112.2APOB, LPL
27oleic acid45 29 24 1112.1APOB, LPL
28lovastatin45 51 61 29 1113.0APOB, LPL
29intralipid459.0APOB, LPL, INS
30orlistat45 61 1111.0INS, LPL, APOB
31starch459.0LPL, INS, APOB
32gemfibrozil29 45 1111.0INS, APOB, LPL
33niacin45 1110.0INS, APOB, LPL
34bezafibrate45 29 1110.9INS, APOB, LPL
35fenofibrate45 51 1110.9APOB, INS, LPL
36metformin45 51 1110.9LPL, APOB, INS
37triacylglycerol458.9INS, APOB, LPL
38pioglitazone29 45 51 1111.9INS, APOB, LPL
39carnitine458.9LPL, APOB, INS
40palmitate458.9INS, LPL, APOB
41rosiglitazone29 45 51 24 1112.9APOB, LPL, INS
42thyroxine45 249.9APOB, LPL, INS
43epinephrine45 24 1110.9INS, LPL, APOB
44fatty acid458.9LPL, INS, APOB
45lactate458.8APOB, LPL, INS
46testosterone45 61 24 1111.7INS, LPL, APOB
47pravastatin45 51 29 24 1112.7APOB, LPL
48dexamethasone45 51 29 1111.7APOB, LPL, INS
49cholesterol45 29 24 1111.4INS, APOB, LPL, ACAT1
50glutamate458.4INS, APOB, LPL

GO Terms for genes affiliated with Lipid Metabolism Disorder

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16Gene Ontology
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Cellular components related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome lumenGO:0319049.4APOB, INS
2chylomicronGO:0426279.1LPL, APOB
3very-low-density lipoprotein particleGO:0343619.0LPL, APOB
4endoplasmic reticulum lumenGO:0057889.0APOB, INS
5extracellular regionGO:0055768.5LPL, APOB, INS
6extracellular spaceGO:0056158.4INS, APOB, LPL

Biological processes related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cholesterol storageGO:0108869.2LPL, APOB
2positive regulation of macrophage derived foam cell differentiationGO:0107449.1LPL, APOB
3triglyceride catabolic processGO:0194339.0APOB, LPL
4phototransduction, visible lightGO:0076039.0LPL, APOB
5lipoprotein metabolic processGO:0421578.9LPL, APOB
6retinoid metabolic processGO:0015238.7LPL, APOB
7small molecule metabolic processGO:0442818.1ACAT1, LPL, APOB, INS

Molecular functions related to Lipid Metabolism Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.0LPL, APOB

Products for genes affiliated with Lipid Metabolism Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lipid Metabolism Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet