MCID: LPB001
MIFTS: 34

Lipoblastoma malady

Cancer category

Summaries for Lipoblastoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 Lipoblastoma is a type of subcutaneous benign fatty tumor. more...

MalaCards: Lipoblastoma is related to myxoid liposarcoma and atypical lipomatous tumor. An important gene associated with Lipoblastoma is COL1A2 (collagen, type I, alpha 2), and among its related pathways are Adipocytokine signaling pathway and AMPK signaling. The compounds xbai and lep (116-130) (mouse) have been mentioned in the context of this disorder. Affiliated tissues include adipocyte, kidney and breast, and related mouse phenotypes are limbs/digits/tail and cardiovascular system.

Aliases & Classifications for Lipoblastoma

Sources:
49Orphanet, 61UMLS, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Characteristics (Orphanet epidemiological data):

49
lipoblastoma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

lipoblastoma 49 61


External Ids:

SNOMED-CT via Orphanet58 400102008
UMLS via Orphanet62 C1260965

Related Diseases for Lipoblastoma

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lipoblastoma:



Diseases related to lipoblastoma

Clinical Features for Lipoblastoma

Drugs & Therapeutics for Lipoblastoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Lipoblastoma

Drug clinical trials:

Search ClinicalTrials for Lipoblastoma

Search NIH Clinical Center for Lipoblastoma

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Genetic Tests for Lipoblastoma

Anatomical Context for Lipoblastoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Lipoblastoma:

33
Adipocyte, Kidney, Breast, Skin, T cells

Animal Models for Lipoblastoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Lipoblastoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.4LEPR, LEP, HAS2, COL1A2
2MP:00053858.4LEPR, LEP, HAS2, COL1A2
3MP:00053698.3COL1A2, HAS2, LEP, LEPR
4MP:00053908.1COL1A2, HAS2, LEP, LEPR
5MP:00053787.5COL1A2, HAS2, LEP, LEPR, PLAG1

Publications for Lipoblastoma

Sources:
51PubMed
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Articles related to Lipoblastoma:

(show top 50)    (show all 216)
idTitleAuthorsYear
1
An isolated digital lipoblastoma. (23789709)
2014
2
Giant lipoblastoma of the thigh: a rare soft tissue tumor in an infant. (22531541)
2012
3
Rearrangement of HMGA2 in a case of infantile lipoblastoma without Plag1 alteration. (22223189)
2012
4
Lipoblastoma mimicking myxoid liposarcoma: a clinical report and literature review. (21212605)
2011
5
Acute respiratory distress caused by a giant mediastinal lipoblastoma in a 16-month-old boy. (22115267)
2011
6
Lipoma-like lipoblastoma arising from the femoral vein. (21249406)
2011
7
Fetal retroperitoneal lipoblastoma: ultrasonographic appearance of a rare embryonal soft tissue tumor. (20718582)
2010
8
MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients. (21092875)
2010
9
Pediatric lipoblastoma in the head and neck: a systematic review of 48 reported cases. (20472310)
2010
10
Mesenteric lipoblastoma presenting as a segmental volvulus. (19231517)
2009
11
Lipoblastoma on the posterior side of the neck. (19817275)
2009
12
A case of maturing perineal lipoblastoma in an infant. (19494545)
2009
13
Postnatal diagnosis of lipoblastoma in a foetus presenting with hydrocephaly. (19455590)
2009
14
Lipoblastoma: a rare mediastinal tumor. (19853146)
2009
15
Lipoblastoma of the back; a case of a 7-month-old boy. (19803275)
2009
16
Lipoblastoma: appreciation of an expanded spectrum of disease through cytogenetic analysis. (18788858)
2008
17
Lipoblastoma arising from the submandibular region. (18970913)
2008
18
Cytogenetic and molecular cytogenetic findings in lipoblastoma. (18474299)
2008
19
Unusual breast enlargement in an infant: a case of breast lipoblastoma. (17051354)
2007
20
Congenital lipoblastoma in a neonate calf: first report in veterinary literature. (17355429)
2007
21
Intrapelvic lipoblastoma with massive spinal canal invasion. (17143644)
2007
22
PLAG1 activation in lipoblastoma coinciding with low-level amplification of a derivative chromosome 8 with a deletion del(8)(q13q21.2). (18160779)
2007
23
Lipoblastoma and infantile lipoma. (17146210)
2006
24
Surgical management of lipoblastoma. (16769336)
2006
25
Radiological-pathological correlation in lipoblastoma and lipoblastomatosis. (16775739)
2006
26
Lipoblastoma of infancy mimicking hemangioma of infancy. (16172343)
2005
27
Lipoblastoma/lipoblastomatosis: a clinicopathologic study of 16 cases in Taiwan. (16180007)
2005
28
Cervical lipoblastoma: an uncommon diagnosis of neck mass. (15100656)
2004
29
Lipoblastoma of the neck: a case report and literature review. (15239035)
2004
30
Mesenteric lipoblastoma: case report. (12497236)
2003
31
Primary cardiac lipoblastoma. (11370265)
2001
32
Lipoblastoma. (11381423)
2001
33
Lipoblastoma: a rare cervical mass in childhood. (11700198)
2001
34
Lipoblastoma with aberration in the long arm of chromosome 8. (10982693)
2000
35
Lipoblastoma of the neck. (10878874)
2000
36
Index of suspicion. Case 2. Lipoblastoma. (10744505)
2000
37
Acral lipoblastoma. (10795087)
2000
38
Leptin and leptin receptor expression in a lipoblastoma in an 8-year-old girl. (10559671)
1999
39
Mediastinal lipoblastoma involving the left innominate vein and the left phrenic nerve. (9802809)
1998
40
Lipoblastoma and liposarcoma in children: an analysis of 9 cases and a review of the literature. (9854536)
1998
41
Intermittent airway obstruction in a child caused by a cervical lipoblastoma. (9265941)
1997
42
Clinical image. Lipoblastoma of the thigh: MR appearance. (8933809)
1996
43
Retroperitoneal lipoblastoma: report of one case. (8607366)
1995
44
Potential diagnostic implications of breakpoints in the long arm of chromosome 8 in lipoblastoma. (8076349)
1994
45
Lipoblastoma: diagnosis with computed tomography, ultrasonography, and color Doppler imaging. (1404586)
1992
46
Benign lipoblastoma and liposarcoma in children. (3728015)
1986
47
Benign lipoblastoma in the mandible. (6841120)
1983
48
A benign inguinal lipoblastoma in a 14-year-old girl. A case report. (6659819)
1983
49
Lipoblastoma in infants and children. (7108715)
1982
50
Benign lipoblastoma and myxoid liposarcoma: a comparative light- and electron-microscopic study. (7377463)
1980

Genetic Variations for Lipoblastoma

Expression for genes affiliated with Lipoblastoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipoblastoma

Search GEO for disease gene expression data for Lipoblastoma.

Pathways for genes affiliated with Lipoblastoma

Sources:
30KEGG, 38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Lipoblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3LEPR, LEP
29.3LEPR, LEP
3
Development Leptin signaling via PI3K-dependent pathway
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9.3LEP, LEPR
49.3LEPR, LEP
5
Development Leptin signaling via JAK/STAT and MAPK cascades
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9.3LEPR, LEP

Compounds for genes affiliated with Lipoblastoma

Sources:
45Novoseek, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Lipoblastoma according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1xbai459.7LEPR, COL1A2
2lep (116-130) (mouse)609.6LEPR, LEP
3nash459.6LEPR, LEP
4olanzapine50 45 29 11 2413.5LEP, LEPR
5triacylglycerol459.5LEPR, LEP
6triiodothyronine459.5LEPR, LEP
7androstenedione45 2410.4LEP, LEPR
8corticosterone45 60 2411.3LEPR, LEP
9cocaine45 1110.3LEPR, LEP
10steroid458.9LEPR, LEP, HAS2
11dexamethasone45 50 29 1111.7HAS2, LEP, LEPR
12phosphatidylinositol458.6LEPR, LEP, COL1A2

GO Terms for genes affiliated with Lipoblastoma

Sources:
16Gene Ontology
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Biological processes related to Lipoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1energy reserve metabolic processGO:0061129.3LEPR, LEP
2regulation of blood pressureGO:0082179.3LEP, COL1A2
3cholesterol metabolic processGO:0082039.0LEPR, LEP

Products for genes affiliated with Lipoblastoma

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Sources for Lipoblastoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet