MCID: LPB001
MIFTS: 41

Lipoblastoma malady

Rare diseases, Cancer diseases categories
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Summaries for Lipoblastoma

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Lipoblastoma is a type of subcutaneous benign fatty tumor. more...

MalaCards: Lipoblastoma is related to mediastinitis and cervicitis. An important gene associated with Lipoblastoma is COL1A2 (collagen, type I, alpha 2), and among its related pathways are Adipocytokine signaling pathway and Prolactin signaling pathway. The compounds ribonucleic acid and xbai have been mentioned in the context of this disorder. Affiliated tissues include bone, adipocyte and breast, and related mouse phenotypes are vision/eye and limbs/digits/tail.

Aliases & Classifications for Lipoblastoma

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Sources:
43NIH Rare Diseases, 49Orphanet, 62UMLS, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 49 
Rare tumors


Characteristics (Orphanet epidemiological data):

49
lipoblastoma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

lipoblastoma 43 49 62


External Ids:

SNOMED-CT via Orphanet59 400102008
UMLS via Orphanet63 C1260965

Related Diseases for Lipoblastoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lipoblastoma:



Diseases related to lipoblastoma

Symptoms for Lipoblastoma

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Drugs & Therapeutics for Lipoblastoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Lipoblastoma

Search NIH Clinical Center for Lipoblastoma

Genetic Tests for Lipoblastoma

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Anatomical Context for Lipoblastoma

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33MalaCards
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MalaCards organs/tissues related to Lipoblastoma:

33
Bone, Adipocyte, Breast, Kidney, Skin, Testes

Animal Models for Lipoblastoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Lipoblastoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5LEPR, LEP, PLAG1
2MP:00053718.5HAS2, LEPR, LEP, COL1A2
3MP:00053698.4LEPR, HAS2, LEP, COL1A2
4MP:00053908.4LEP, LEPR, HAS2, COL1A2
5MP:00053858.3LEPR, HAS2, LEP, COL1A2
6MP:00053868.1HAS2, LEPR, LEP, COL1A2
7MP:00053787.6HAS2, LEPR, LEP, PLAG1, COL1A2

Publications for Lipoblastoma

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52PubMed
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Articles related to Lipoblastoma:

(show top 50)    (show all 213)
idTitleAuthorsYear
1
An isolated digital lipoblastoma. (23789709)
2014
2
Desmin-positivity in spindle cells: under-recognized immunophenotype of lipoblastoma. (23865573)
2013
3
Diagnostic utility of molecular and cytogenetic analysis in lipoblastoma: a study of two cases and review of the literature. (24433523)
2013
4
A novel PLAG1-RAD51L1 gene fusion resulting from a t(8;14)(q12;q24) in a case of lipoblastoma. (23890983)
2013
5
Giant omental lipoblastoma and CD56 expression. (23519855)
2013
6
Intrascrotal lipoblastoma in a ten year old: case report and review of literature. (23772297)
2013
7
Multifocal lipoblastoma of the face. (23172486)
2012
8
A giant mesenteric lipoblastoma in an 18-month old infant: a case report and review of the literature. (22248900)
2011
9
Intrathoracic lipoblastoma in a 15-month-old infant. (22355506)
2011
10
A case of lipoblastoma with seven copies of chromosome 8. (19264235)
2009
11
Lipoblastoma--an unfamiliar but important diagnosis. A case series and literature review. (19774822)
2009
12
Mesenteric lipoblastoma presenting as a segmental volvulus. (19231517)
2009
13
Lipoblastoma on the posterior side of the neck. (19817275)
2009
14
Giant mesenteric lipoblastoma in a 4-year-old child. (19361656)
2009
15
Lipoblastoma in adolescents and young adults: report of six cases with FISH analysis. (18269579)
2008
16
Lipoblastoma in children: an analysis of 5 cases. (19051470)
2008
17
Lipoblastoma: appreciation of an expanded spectrum of disease through cytogenetic analysis. (18788858)
2008
18
Unusual breast enlargement in an infant: a case of breast lipoblastoma. (17051354)
2007
19
Congenital lipoblastoma in a neonate calf: first report in veterinary literature. (17355429)
2007
20
Benign intrascrotal lipoblastoma in a child. (17826513)
2007
21
Omental lipoblastoma. (18693617)
2007
22
Lipoblastoma and infantile lipoma. (17146210)
2006
23
A thoracic wall lipoblastoma in a 3-month-old infant: A case report and review of the literature. (17006266)
2006
24
Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology. (16308870)
2006
25
Lipoblastoma in a four-year-old African child. (16338874)
2005
26
Lipoblastoma of the neck mimicking cystic hygroma. (15746874)
2005
27
Lipoblastoma in an 11-month-old infant. (15322609)
2004
28
Intrascrotal lipoblastoma with a complex karyotype: a case report and review of the literature. (15214818)
2004
29
Axillary lipoblastoma--tumor recurrence in the right atrium. (12891504)
2003
30
Primary cardiac lipoblastoma. (11370265)
2001
31
PLAG1 fusion oncogenes in lipoblastoma. (10987300)
2000
32
Lipoblastoma with aberration in the long arm of chromosome 8. (10982693)
2000
33
A further case of chromosome 8q rearrangement in lipoblastoma. (11037871)
2000
34
Ruptured giant intrathoracic lipoblastoma in a 4-month-old infant: CT and MR findings. (10663508)
2000
35
Evidence by spectral karyotyping that 8q11.2 is nonrandomly involved in lipoblastoma. (11272891)
2000
36
"Lipoblastoma-like" lipoatrophy induced by human insulin: morphological evidence for local dedifferentiation of adipocytes? (10952472)
2000
37
Lipoblastoma: MRI appearances of a rare paediatric soft tissue tumour. (10398794)
1999
38
Lipoblastoma presenting as a mesenteric mass in an infant. (9856685)
1998
39
Lipoblastoma: a case with t(7;8)(q31;q13). (9530333)
1998
40
Chromosomal aberration in lipoblastoma: a case with 46,XX,ins(8;6)(q11.2;q13q27). (9169035)
1997
41
Lipoblastoma of the foot. (8741069)
1996
42
An unusual intrathoracic tumor: giant lipoblastoma. (7756235)
1995
43
New discriminative chromosomal marker in adipose tissue tumors. The chromosome 8q11-q13 region in lipoblastoma. (7828158)
1994
44
Potential diagnostic implications of breakpoints in the long arm of chromosome 8 in lipoblastoma. (8076349)
1994
45
Lipoblastoma and lipoblastomatosis--a report of six cases. (3413688)
1988
46
Benign lipoblastoma: first case report of a mesenteric origin. (3188249)
1988
47
CT appearance of cervical lipoblastoma. (3734216)
1986
48
Benign lipoblastoma in the mandible. (6841120)
1983
49
Benign lipoblastoma in the neck causing respiratory insufficiency. (6865630)
1983
50
Benign lipoblastoma and myxoid liposarcoma: a comparative light- and electron-microscopic study. (7377463)
1980

Variations for Lipoblastoma

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Expression for genes affiliated with Lipoblastoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipoblastoma

Search GEO for disease gene expression data for Lipoblastoma.

Pathways for genes affiliated with Lipoblastoma

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome
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Pathways related to Lipoblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3LEP, LEPR
2
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.3LEP, LEPR
3
Show member pathways
Type III interferon signaling38
9.3LEP, LEPR
49.3LEPR, LEP
59.3LEP, LEPR
6
Show member pathways
9.3LEP, LEPR
79.3LEP, LEPR
8
Show member pathways
9.3LEP, LEPR

Compounds for genes affiliated with Lipoblastoma

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Sources:
45Novoseek, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 11DrugBank
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Compounds related to Lipoblastoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1ribonucleic acid4510.0COL1A2
2xbai459.8COL1A2, LEPR
3simvastatin45 51 61 29 24 1114.7LEPR, COL1A2
4lep (116-130) (mouse)619.7LEPR, LEP
5nash459.7LEPR, LEP
6olanzapine45 51 29 24 1113.7LEPR, LEP
7triacylglycerol459.7LEP, LEPR
8triiodothyronine459.6LEPR, LEP
9androstenedione45 2410.6LEPR, LEP
10corticosterone45 61 2411.6LEPR, LEP
11cocaine45 1110.6LEPR, LEP
12thyroxine45 2410.5LEP, LEPR
13hyaluronic acid45 2410.4LEP, HAS2
14prostacyclin459.4LEP, HAS2
15acth459.3LEPR, LEP
16gnrh459.2LEP, LEPR
17phosphatidylinositol459.1LEPR, COL1A2, LEP
18steroid459.1HAS2, LEPR, LEP
19estrogen459.1COL1A2, LEPR, LEP
20dexamethasone45 51 29 1112.1HAS2, LEPR, LEP
21cysteine459.1COL1A2, LEP, LEPR
22glucose459.0HAS2, LEPR, LEP
23lipid458.5LEP, LEPR, HAS2

GO Terms for genes affiliated with Lipoblastoma

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16Gene Ontology
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Biological processes related to Lipoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1energy reserve metabolic processGO:0061129.3LEP, LEPR
2regulation of blood pressureGO:0082179.3COL1A2, LEP
3cholesterol metabolic processGO:0082039.0LEP, LEPR

Products for genes affiliated with Lipoblastoma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Lipoblastoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet