Lipodystrophy malady

NIH Rare Diseases: Lipodystrophy refers to a collection of conditions caused by a problem with fat (lipid) metabolism. These conditions can be subclassified in a variety of ways. For example there are generalized, localized, congenital, and acquired forms of lipodystrophy. These conditions are characterized by the destruction (atrophy) of fatty (adipose) tissue. In many of the lipodystrophies there is a redistribution of body fat resulting in the fat collecting primarily in the center of the body.³⁰

MalaCards: Lipodystrophy, also known as lipodystrophy nos (disorder), is related to congenital generalized lipodystrophy and familial partial lipodystrophy. An important gene associated with Lipodystrophy is BSCL2 (Berardinelli-Seip congenital lipodystrophy 2 (seipin)), and among its related pathways are Adipocytokines & Insulin Signaling and Glucose / Energy Metabolism. The compounds c-peptide and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include heart, skeletal muscle and adipocyte, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia: Lipodystrophy is a medical condition characterized by abnormal or degenerative conditions of the body\'s...⁴⁴ more...

Aliases & Descriptions:

lipodystrophy 6 7 30 8 32 43 lipodystrophy nos (disorder) 6

lipodystrophy (disorder) 6

Diseases related to lipodystrophy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 772)

id	Related Disease	Score	Top Affiliating Genes
1	congenital generalized lipodystrophy	36.4	BSCL2, LMNA, LEP, GZMH, INS, CAV1
2	familial partial lipodystrophy	36.4	BSCL2, LMNA, LEP, INS, PPARG, AGPAT2
3	muscular dystrophy	32.0	LMNA, LMNB1, CAPN3, CAV3, CAV1, EMD
4	mandibuloacral dysplasia	31.3	BSCL2, LMNA, ZMPSTE24, INS, PPARG, AGPAT2
5	lipoatrophic diabetes	30.7	RETN, LEP, INS, PPARG, ADIPOQ
6	obesity	30.5	UCP1, CARTPT, GHRL, ADRB2, ADRB3
7	immunodeficiency	30.0	CD4, INS, INSR, IL18, IL6, FBN1
8	emery-dreifuss muscular dystrophy	29.3	LMNA, LMNB1, LMNB2, EMD
9	hepatitis	28.7	RBP4, FAS, GPT, HLA-A, HLA-DRB1, TNFRSF1A
10	panniculitis	28.7	CIDEC, FAS, IGFBP3, TNF, PSMB8
11	progeria	28.6	LMNA, LMNB1, LMNB2, ZMPSTE24, INS, EMD
12	sleep apnea	28.3	RETN, LEP, GHR, LSL, ADRB2, ADIPOQ
13	cholesteryl ester storage disease	28.1	LIPA, LDLR, HMGCR, GBA
14	acanthosis nigricans	27.6	BSCL2, LMNA, LEP, INS, INSR, IGF1R
15	cushing's syndrome	27.0	GH1, SST, NR3C1
16	polycystic ovary syndrome	26.8	LEP, INS, INSR, IGFBP1, IGF1R, IGFBP3
17	thyroid hormone metabolism	26.4	INS, IL6, IGF1, TNFRSF1A, DIO1, DIO2
18	retinol binding protein	26.1	RETN, RBP4, NAMPT, LPA, RARB, LIPC
19	acute lymphoblastic leukemia	25.8	CDK1, ITGAM, APOB, IGFBP1, HMGA2, HLA-B
20	hypertrophic cardiomyopathy	25.1	RETN, LMNA, INS, IL6, CCL2, IGFBP1
21	respiratory failure	24.5	RBP4, CD4, ITGAM, INS, IL6, GPT
22	proteinuria	24.3	RBP4, SERPINE1, LPA, LIPA, LEP, CETP
23	cataract	24.1	LMNA, LEP, INS, IL6, FBN1, APOE
24	nonalcoholic steatohepatitis	24.0	RETN, SERPINE1, LPA, LPL, LEP, INS
25	insulin resistance	23.7	LRP1, RETN, RBP4, SERPINE1, BSCL2, NAMPT
26	growth hormone deficiency	23.7	RETN, SERPINE1, LPA, LPL, LIPE, LEP
27	hypertriglyceridemia	23.5	LRP1, RBP4, SERPINE1, BSCL2, NAMPT, LPA
28	neurodegeneration	23.4	LRP1, BSCL2, YWHAE, YWHAZ, LDLR, CETP
29	amyloidosis	23.3	LRP1, RBP4, LPA, LPL, ZMPSTE24, INS
30	dermatomyositis	22.9	CD4, INS, IL6, FBN1, FAS, CCL2
31	apnea	21.8	RETN, RBP4, SERPINE1, NAMPT, LPL, LMNA
32	hyperlipidemia	21.7	LRP1, RETN, RBP4, SERPINE1, NAMPT, LPA
33	glomerulonephritis	21.4	LRP1, RBP4, SERPINE1, LPA, LMNA, LMNB2
34	acromegaly	21.2	RETN, RBP4, SERPINE1, NAMPT, LPA, LPL
35	myopathy	20.6	BSCL2, LMNA, LMNB1, LEP, MT-ND6, CD4
36	lymphoblastic leukemia	20.0	SERPINE1, LPL, LMNB1, RARB, LEP, CDK1
37	neuropathy	19.7	RETN, SERPINE1, BSCL2, LMNA, LMNB1, LEP
38	anemia	19.7	NAMPT, LPIN2, LPL, LMNA, RARB, LIPA
39	atherosclerosis	19.4	LRP1, RETN, RBP4, SERPINE1, NAMPT, LPA
40	type 2 diabetes mellitus	19.3	RETN, RBP4, SERPINE1, NAMPT, LPA, LPIN1
41	diabetes mellitus	18.9	RETN, RBP4, SERPINE1, BSCL2, NAMPT, LPA
42	peritonitis	18.7	LRP1, RBP4, SERPINE1, NAMPT, LPA, LPL
43	cervicitis	18.4	SERPINE1, BSCL2, RARB, LEP, LDLR, CD4
44	nephropathy	18.3	LRP1, RETN, RBP4, SERPINE1, NAMPT, LPA
45	hypertension	17.4	LRP1, RETN, RBP4, SERPINE1, NAMPT, LPA
46	leukemia	15.1	LRP1, RETN, RBP4, SERPINE1, NAMPT, LPL
47	majeed syndrome	14.1	LPIN1, LPIN2, LPIN3
48	diabetes, type 2	14.1	INS, IL18, PPARG, NR1H2, ADIPOQ
49	chronic kidney failure	14.1	LPL, LEP, INS, APOC3, HMGCR, NR1H2
50	high blood pressure	14.1	RETN, LPL, LEP, INS, CS, ADRB3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to lipodystrophy:

²²

MGI Mouse Phenotypes related to lipodystrophy:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	GBA, ABCA1, PPARGC1A, APOE, FBN1, INSR
2	endocrine/exocrine gland phenotype	MP:0005379	10.2	ADRB3, LTA, LDLR, DIO1, HMGA2, GHRH
3	renal/urinary system phenotype	MP:0005367	9.9	CAV1, GHR, TNFRSF1B, DIO1, DIO2, RPS6KA3
4	limbs/digits/tail phenotype	MP:0005371	9.9	HMGA2, TNFRSF1A, CRABP1, CRABP2, LTA, AGPAT2
5	hematopoietic system phenotype	MP:0005397	9.9	AGPAT2, RPS6KA3, HLA-DQB1, HLA-C, APC, FBN1
6	other phenotype	MP:0005395	9.8	C3, ABCA1, NR1H2, TNFRSF1A, CAV1, APOE
7	pigmentation phenotype	MP:0001186	9.5	CCL2, FAS, APOE, APOB, APC, FBN1
8	liver/biliary system phenotype	MP:0005370	9.4	AGPAT2, HSD11B1, IGFBP1, FABP4, APOB, APOA1
9	no phenotypic analysis	MP:0003012	9.0	GHRL, HLA-C, SST, PPARG, RPS6KA3, POLG
10	integument phenotype	MP:0010771	8.7	GBA, POLG, AGPAT2, RPS6KA3, FAS, APC
11	hearing/vestibular/ear phenotype	MP:0005377	8.6	PPARG, CRABP1, CRABP2, PLAT, RPS6KA3, POLG
12	nervous system phenotype	MP:0003631	8.5	GBA, HLA-C, HMGA2, GHRH, GHR, CAV1
13	digestive/alimentary phenotype	MP:0005381	8.4	C3, DIO1, GHRL, CAV1, IGF1R, CCL2
14	reproductive system phenotype	MP:0005389	8.4	GHRH, LIPC, LIPE, RARB, LMNA, LPIN1
15	skeleton phenotype	MP:0005390	8.0	PPARG, TNFRSF1B, TNFRSF1A, AKT2, CAV1, NR1H2
16	immune system phenotype	MP:0005387	7.8	RPS6KA3, PLAT, NR3C1, PPARD, PPARA, TNFRSF1A
17	normal phenotype	MP:0002873	7.8	HTT, CAPN3, AKT2, GHRL, HMGCR, HLA-DQB1
18	vision/eye phenotype	MP:0005391	7.7	TNFRSF1A, TNF, CCL2, ANGPTL4, TNFRSF1B, SREBF2
19	tumorigenesis	MP:0002006	7.1	AKT2, TNF, TNFRSF1A, TNFRSF1B, PPARGC1A, PPARG
20	muscle phenotype	MP:0005369	7.1	LIPE, LRP1, ZMPSTE24, RARB, LMNB2, LMNB1
21	growth/size phenotype	MP:0005378	6.8	DIO1, FABP4, APOE, APOC3, APOB, APC
22	adipose tissue phenotype	MP:0005375	6.7	PPARA, CARTPT, HSD11B1, IGF1, IGFBP3, IGF1R
23	behavior/neurological phenotype	MP:0005386	6.5	EMD, C3, AGPAT2, LTA, RPS6KA3, PLIN1
24	mortality/aging	MP:0010768	6.2	FBN1, RARB, LMNB2, LMNB1, LMNA, LMF1
25	cellular phenotype	MP:0005384	4.7	CAV1, FBN1, IL6, IL18, INSR, INS
26	cardiovascular system phenotype	MP:0005385	4.1	GBA, ADIPOQ, ADRB2, EMD, C3, SLC2A4
27	homeostasis/metabolism phenotype	MP:0005376	2.2	GBA, ADIPOQ, ADRB3, IGF1, APC, FBN1

Articles related to lipodystrophy:

(show top 50)    (show all 311)

id	Title	Authors	Year	Affiliating Genes
1	Characterisation of non-obese diabetic patients with marked insulin resistance identifies a novel familial partial lipodystrophy-ass ociated PPARI^ mutation (Y151C). (21479595)	Visser M.E.... Monajemi H.	2011	PPARG
2	A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans. (21881205)	Kitamura A.... Yasutomo K.	2011	PSMB8
3	Acquired partial lipodystrophy with C3 hypocomplement emia and antiphospholipid and anticardiolipin antibodies. (20807366)	Yavuz S.... AcartA1rk T.O.	2010	C3
4	TNF microsatellite alleles may confer protection agai nst the development of lipodystrophy syndrome in Brazilian HIV patients. (20518840)	Silva M.M.... Fernandes A.P.	2010	TNF
5	Leptin therapy in lipodystrophy. (19802712)	Savage D.B.... O'Rahilly S.	2010	LEP
6	Inherited lipodystrophies and hypertriglyceridemia. (19494770)	Simha V.... Garg A.	2009	PPARG, LMNA
7	Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. (20049731)	Rubio-Cabezas O.... Savage D.B.	2009	INS, CIDEC
8	Serum retinol binding protein 4 in patients with fami lial partial lipodystrophy. (19303000)	Godoy-Matos A.F.... Moises R.S.	2009	RBP4
9	PPARgamma Pro12Ala polymorphism in HIV-1-infected pat ients with HAART-related lipodystrophy. (19534662)	Saumoy M.... Vidal F.	2009	PPARG
10	GH/GHRH axis in HIV lipodystrophy. (18270841)	Stanley T.L.... Grinspoon S.K.	2009	GH1
11	The role of LMNA in adipose: a novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutation. (19201734)	Wojtanik K.M.... Londos C.	2009	LMNA
12	Dietary intake in HIV-infected men with lipodystrophy : relationships with body composition, visceral fat, lipid, glucose and adipoki ne metabolism. (19601783)	Samaras K.... Carr A.	2009	ADIPOQ, INS
13	Adiponectin and leptin levels in Chinese patients wit h HIV-related lipodystrophy: a 30-month prospective study. (20001516)	Luo L.... Li T.	2009	LEP, ADIPOQ
14	The human lipodystrophy gene product Berardinelli-Sei p congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiati on. (19574402)	Chen W.... Chan L.	2009	BSCL2
15	Relationship between polymerase gamma (POLG) polymorphisms and antiretroviral therapy-induced lipodystrophy in HIV-1 infected patients: a case-control study. (19275594)	Chiappini F.... Lemoine A.	2009	POLG
16	Severe mandibuloacral dysplasia-associated lipodystrophy and progeria in a young girl with a novel homozygous Arg527Cys LMNA mutation. (18796515)	Agarwal A.K.... Garg A.	2008	LMNA, ZMPSTE24
17	Mitochondrial DNA haplogroups and highly active antiretroviral therapy-related lipodystrophy. (18752438)	Nasi M.... Cossarizza A.	2008	APOA1
18	Effect of depot medroxyprogesterone acetate on glucose tolerance in generalized lipodystrophy. (18669758)	Yauger B.J.... Stratton P.	2008	LEP, INS
19	Primary lipodystrophies (17320032)	Capeau J.... Vigouroux C.	2007	LMNA, AGPAT2, ZMPSTE24
20	Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus--associated lipodystrophy syndrome. (17950103)	Miranda M.... Vendrell J.	2007	LPIN1
21	Is oxygen a key factor in the lipodystrophy phenotype? (17049073)	Gentil C.... Pietri-Rouxel F.	2006	ANGPTL4
22	Diabetes with partial lipodystrophy following sclerodermatous chronic graft vs. host disease. (16620274)	Rooney D.P.... Ryan M.F.	2006	INS
23	Congenital generalized lipodystrophy in a 4 year old Chinese girl. (16269843)	Dong G.... Zou C.	2005	INS
24	Lipodystrophy in patients with HIV-1 infection: effect of stopping protease inhibitors on TNF-alpha and TNF-receptor levels, and on metabolic parameters. (15651746)	Maher B.... Pirmohamed M.	2004	TNFRSF1A, TNFRSF1B
25	Tumor-level serum testosterone associated with human immunodeficiency virus lipodystrophy syndrome. (15121620)	Dahan M.H.... Chang R.J.	2004	INS
26	Different growth hormone sensitivity of target tissues and growth hormone response to glucose in HIV-infected patients with and without lipodystrophy. (15764170)	Andersen O.... Flyvbjerg A.	2004	GHR
27	Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A/C gene mutations. (15372542)	Muchir A.... Bonne G.	2004	LMNA
28	Metabolic effects of rosiglitazone in HIV lipodystrophy: a randomized, controlled trial. (15148065)	Hadigan C.... Grinspoon S.	2004	PPARG, ADIPOQ
29	Low-dose growth hormone and human immunodeficiency virus-associated lipodystrophy syndrome: a pilot study. (15305891)	Andersen O.... Iversen J.	2004	IGF1
30	Acquired and inherited lipodystrophies. (15028826)	Garg A.	2004	AGPAT2
31	Unbuckling lipodystrophy from insulin resistance and hypertension. (15254581)	Hegele R.A.... Leff T.	2004	PPARG, INS
32	Lipodystrophy, insulin resistance, diabetes mellitus, dyslipidemia, and cardiovascular disease in human immunodeficiency virus infection. (12630645)	Tanwani L.K.... Mokshagundam S.L.	2003	INS
33	Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy. (12824788)	Vigouroux C.... Bastard J.P.	2003	CRP, ADIPOQ, INS
34	Prevalence of mutations in AGPAT2 among human lipodystrophies. (12765973)	MagrAc J.... Lathrop M.	2003	INS
35	Health risks of lipodystrophy and abdominal fat accumulation: therapeutic possibilities with leptin and human growth hormone. (12914718)	Van Gaal L.F.... Abrams P.J.	2003	TNF, LEP, ADIPOQ
36	A search for candidate genes for lipodystrophy, obesity and diabetes via gene expression analysis of A-ZIP/F-1 mice. (12676562)	Mir A.A.... Vinson C.	2003	LEP
37	Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy. (12502655)	Simha V.... Garg A.	2003	LEP, INS
38	Congenital generalized lipodystrophy: significance of triglyceride biosynthetic pathways. (12826327)	Agarwal A.K.... Garg A.	2003	BSCL2
39	Increased serum interferon alpha in HIV-1 associated lipodystrophy syndrome. (11851726)	Christeff N.... Gougeon M.L.	2002	LPA
40	A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. (11929849)	Lloyd D.J.... Shackleton S.	2002	LMNA, SREBF1
41	Antiretoviral therapy and the lipodystrophy syndrome, part 2: concepts in aetiopathogenesis. (11808750)	Nolan D.... Mallal S.	2001	CDIPT
42	A case of congenital generalized lipodystrophy: metabolic effects of four dietary regimens. Lack of association of CGL with polymorphism in the lamin A/C Gene. (11298098)	Kazlauskaite R.... Wajchenberg B.L.	2001	LMNA
43	Metformin in the treatment of HIV lipodystrophy syndrome: A randomized controlled trial. (10904511)	Hadigan C.... Grinspoon S.	2000	INS
44	Lessons from lipodystrophy: LMNA, encoding lamin A/C, in HIV therapy-associated lipodystrophy. (10985325)	Behrens G.M.... Trembath R.C.	2000	LMNA
45	Changes in cortisol/DHEA ratio in HIV-infected men are related to immunological and metabolic perturbations leading to malnutrition and lipodystrophy. (11268428)	Christeff N.... Gougeon M.L.	2000	APOB
46	Lamin A/C mutation in a woman and her two daughters with Dunnigan-type partial lipodystrophy and insulin resistance. (10868844)	Hegele R.A.... Cao H.	2000	LMNA, INS
47	The IGF-I/IGFBP system in congenital partial lipodystrophy. (9876344)	Janssen J.A.... Lamberts S.W.	1998	IGF1R, IGF1, IGFBP1
48	Studies of insulin resistance in congenital generalized lipodystrophy. (8783770)	SA... Pedersen O.	1996	INS
49	Generalised lipodystrophy. (2392709)	Choo K.E.... Mafauzy M.	1990	INS
50	The efficacy of using single-component insulin preparations in diabetes mellitus and generalized lipodystrophy (2194203)	Gorelysheva V.A.... Arbuzova M.I.	1990	INS

Genes related to lipodystrophy according to GeneCards:

(show top 50)    (show all 130)

id	Symbol	Description	Score	GeneCards Section Context
1	BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	11.1	Aliases & Descriptions, Transcripts, Orthologs, Publications (show all 5 sections) Summaries
2	AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	11.1	Publications, Aliases & Descriptions, Summaries
3	LMNA	lamin A/C	11.1	Publications, Summaries
4	PTRF	polymerase I and transcript release factor	11.1	Summaries, Publications
5	LMNB2	lamin B2	11.1	Summaries, Publications
6	CAV1	caveolin 1, caveolae protein, 22kDa	11.1	Publications, Summaries
7	LPIN3	lipin 3	11.1	Publications, Summaries
8	LPIN1	lipin 1	11.0	Publications, Summaries
9	LPIN2	lipin 2	11.0	Summaries, Publications
10	INS	insulin	11.0	Publications
11	LEP	leptin	11.0	Publications
12	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications
13	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
14	ZMPSTE24	zinc metallopeptidase STE24 homolog (S. cerevisiae)	11.0	Publications
15	EMD	emerin	11.0	Publications
16	RETN	resistin	11.0	Publications
17	LSL	Leptin, serum levels of	11.0	Publications
18	SREBF1	sterol regulatory element binding transcription factor 1	11.0	Orthologs, Publications
19	HNRNPUL2-BSCL2	HNRNPUL2-BSCL2 readthrough	11.0	Summaries
20	LMNB1	lamin B1	11.0	Publications
21	INSR	insulin receptor	11.0	Publications
22	GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)	11.0
23	DIO3	deiodinase, iodothyronine, type III	11.0	Publications
24	GPAT2	glycerol-3-phosphate acyltransferase 2, mitochondrial	11.0
25	CDIPT	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	11.0	Publications
26	CRABP1	cellular retinoic acid binding protein 1	11.0	Publications
27	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	11.0	Publications
28	DIO2	deiodinase, iodothyronine, type II	11.0	Publications
29	DIO1	deiodinase, iodothyronine, type I	11.0	Publications
30	POLG2	polymerase (DNA directed), gamma 2, accessory subunit	11.0	Publications
31	PLIN1	perilipin 1	11.0
32	SLC16A2	solute carrier family 16, member 2 (thyroid hormone transporter)	11.0	Publications
33	CRABP2	cellular retinoic acid binding protein 2	11.0	Publications
34	POLG	polymerase (DNA directed), gamma	11.0	Publications
35	SREBF2	sterol regulatory element binding transcription factor 2	11.0	Orthologs
36	ADRB3	adrenoceptor beta 3	11.0	Publications
37	LIPE	lipase, hormone-sensitive	11.0	Publications
38	CAPN3	calpain 3, (p94)	11.0	Publications
39	AKT2	v-akt murine thymoma viral oncogene homolog 2	11.0	Publications
40	APOC3	apolipoprotein C-III	11.0	Publications
41	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
42	HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	11.0	Publications
43	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	11.0	Publications
44	C3	complement component 3	11.0	Publications
45	RARB	retinoic acid receptor, beta	11.0	Publications
46	NR1H2	nuclear receptor subfamily 1, group H, member 2	11.0	Publications
47	LDLR	low density lipoprotein receptor	11.0	Publications
48	LPL	lipoprotein lipase	11.0	Publications
49	APOB	apolipoprotein B (including Ag(x) antigen)	11.0	Publications
50	GHR	growth hormone receptor	11.0	Publications

Pathways related to lipodystrophy according to GeneDecks:

(show top 50)    (show all 127)

id	Pathway	Score	Top Affiliating Genes
1	Adipocytokines & Insulin Signaling37	10.8	INSR, INS, LEP, NAMPT, RBP4, RETN
2	Glucose / Energy Metabolism3	10.8	ADIPOQ, SLC2A4, PLIN1, LPIN1, PPARG, PPARGC1A
3	Metabolism of lipids and lipoproteins38	10.7	GPAT2, HSD11B1, SREBF1, PLIN1, AGPAT1, SLC27A1
4	PPAR signaling pathway20	10.5	LPL, SLC27A1, PLIN1, PPARD, PPARA, PPARG
5	Adipocytokine signaling pathway20	10.4	LEP, AKT2, TNF, ADIPOQ, SLC2A4, PPARA
6	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis10	10.4	YWHAH, YWHAB, YWHAE, YWHAG, YWHAQ, YWHAZ
7	Apoptosis and survival_BAD phosphorylation41	10.4	YWHAZ, YWHAB, YWHAE, AKT2, RPS6KA3, YWHAQ
8	Statin Pathway, Pharmacodynamics34	10.4	HMGCR, APOE, APOC3, LRP1, LPL, APOA1
9	G2-M Phase Transition36	10.3	YWHAE, YWHAG, PSMB8, CDC25C, YWHAZ, YWHAQ
10	14-3-3 and Cell Cycle Regulation36	10.3	YWHAE, YWHAB, YWHAZ, YWHAG, WEE1, CCNB1
11	Cell cycle Role of 14-3-3 proteins in cell cycle regulation10	10.3	YWHAG, WEE1, AKT2, CDK1, CDC25C, YWHAZ
12	Cell cycle_Role of 14-3-3 proteins in cell cycle regulation41	10.3	WEE1, YWHAB, YWHAG, YWHAZ, YWHAH, CDC25C
13	Apoptosis and survival BAD phosphorylation10	10.2	YWHAQ, YWHAZ, CDK1, IGF1R, AKT2, RPS6KA3
14	14-3-3 and Regulation of BAD Activity36	10.2	YWHAG, YWHAH, YWHAQ, YWHAZ, FOXO3, YWHAE
15	Graft-versus-host disease20	10.2	HLA-A, HLA-DPB1, HLA-C, HLA-B
16	Insulin Receptor Pathway36	10.2	YWHAQ, YWHAH, YWHAG, YWHAZ, FOXO3, INSR
17	BDNF Pathway36	10.2	YWHAH, YWHAZ, RPS6KA3, YWHAG, YWHAQ, YWHAB
18	14-3-3 Induced Apoptosis36	10.1	FOXO3, TNF, LTA, YWHAB, TNFRSF1A, YWHAZ
19	PGC1Alpha Pathway36	10.1	CD4, SLC2A4, PPARGC1A, TNFRSF1B, PPARA, TNFRSF1A
20	Apoptosis and Autophagy3	10.1	YWHAQ, TNFRSF1A, YWHAZ, LMNA, LMNB1, LMNB2
21	Selected targets of GCR-alpha10	10.0	NR3C1, GHR, IGFBP1, ANGPTL4, IL6, INSR
22	Apoptosis Signaling Pathways37	10.0	YWHAH, TNF, FAS, YWHAZ, YWHAG, TNFRSF1A
23	Apoptosis and survival_Caspase cascade41	10.0	TNF, FAS, IGF1, AKT2, IGF1R, LMNB2
24	Apoptosis and survival Caspase cascade10	10.0	IGF1R, TNFRSF1A, TNF, AKT2, IGF1, FAS
25	Cell cycle20	9.9	WEE1, YWHAB, CDK1, CDC25C, YWHAZ, CCNB1
26	Development_Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis41	9.9	YWHAE, YWHAB, YWHAZ, IGF1R, IGF1, AKT2
27	Cell Cycle / Checkpoint Control3	9.8	YWHAQ, WEE1, CDC25C, TYMS, CDK1, LMNA
28	BAD Phosphorylation36	9.8	YWHAE, IGF1, YWHAQ, YWHAB, YWHAH, RPS6KA3
29	Development IGF-RI signaling10	9.7	IGFBP3, IGF1, AKT2, IGF1R, FOXO3, IGFBP1
30	IGF1R Signaling36	9.7	YWHAQ, SLC2A4, YWHAZ, FOXO3, IGF1R, YWHAH
31	Oocyte meiosis20	9.6	CDC25C, CDK1, INS, CCNB1, YWHAZ, IGF1
32	14-3-3 Induced Intracellular Signaling36	9.5	YWHAZ, IGF1R, YWHAQ, INSR, IGF1, TNFRSF1A
33	Development_IGF-1 receptor signaling41	9.5	RPS6KA3, AKT2, IGF1, IGF1R, IGFBP3, IGFBP1
34	Selected targets of HNF110	9.3	ABCA1, APOB, APOA1, INS, LPA, IGFBP1
35	Allograft rejection20	9.2	HLA-B, HLA-DPB1, HLA-DQB1, HLA-A, TNF, FAS
36	Type I diabetes mellitus20	9.2	HLA-DQB1, LTA, TNF, HLA-B, HLA-DRB1, HLA-DPB1
37	Akt Signaling36	9.1	IL6, IGF1R, IL18, LTA, SLC2A4, CXCL12
38	p70S6K Signaling36	9.0	YWHAZ, YWHAB, IGF1, YWHAE, YWHAG, GH1
39	DHA Signaling36	8.9	IGF1R, IGF1, AKT2, YWHAQ, YWHAH, YWHAZ
40	Antigen processing and presentation20	8.9	CD4, HLA-C, HLA-DPB1, HLA-DQB1, HLA-DRB1
41	ERK5 Signaling36	8.9	IL6, YWHAE, IGF1R, YWHAH, YWHAQ, YWHAZ
42	PPAR Pathway36	8.8	IGF1, PPARG, ITGAM, IL6, IGF1R, PPARA
43	Molecular Mechanisms of Cancer36	8.7	CD4, APC, FBN1, RARB, IL6, TNFRSF1B
44	Apoptotic Pathways in Synovial Fibroblasts36	8.7	TNFRSF1A, LTA, TNFRSF1B, IGF1R, IL6, CXCL12
45	JAK-STAT Pathway36	8.1	GH1, CXCL12, TNFRSF1B, TNFRSF1A, GHRH, GHR
46	Activation of PKA through GPCR36	8.0	GHRH, LIPE, ADRB3, ADRB2, CXCL12, YWHAB
47	p38 Signaling36	7.9	GHRH, GH1, IGF1, IGF1R, CCL2, TNF
48	Tec Kinases Signaling36	7.9	CD4, TNFRSF1A, TNF, GHRH, GH1, IGF1
49	Activation of cAMP-Dependent PKA36	7.9	YWHAE, CRP, LIPE, YWHAB, YWHAG, YWHAH
50	cAMP Pathway36	7.8	CRP, IL6, YWHAQ, YWHAZ, AKT2, GH1

Compounds related to lipodystrophy according to GeneDecks:

(show top 50)    (show all 384)

id	Compound	Score	Top Affiliating Genes
1	c-peptide32	10.2	RETN, LEP, UCP1, INSR, GHR, GHRL
2	rapamycin32 42	11.0	LDLR, CDK1, FOXO3, INS, CCNB1, IGF1R
3	isoproterenol32 9 9	11.8	LIPE, ITGAM, INSR, APC, CAV3, GH1
4	palmitate32	9.7	LIPA, LDLR, UCP1, CETP, APOA1, FABP4
5	h2o232	9.7	LPA, LEP, LDLR, UCP1, ITGAM, INSR
6	glycerol32 9 18 9	12.6	LPL, LIPE, LIPC, LEP, CDK1, INS
7	aspartate32	9.6	RETN, RBP4, LIPE, LDLR, UCP1, CETP
8	cholesterol ester32	9.6	LRP1, LPA, LIPA, LIPE, LIPC, LDLR
9	intralipid32	9.5	LPL, LIPC, LEP, CETP, APOA1, APOB
10	pge232	9.5	LDLR, CD4, APC, APOA1, IGF1R, TNFRSF1B
11	sterol32	9.4	LRP1, RETN, LIPE, LIPC, LDLR, CETP
12	ibmx32	9.4	LPL, RARB, INS, INSR, APOE, IGF1R
13	phospholipid32	9.3	RBP4, LPL, LIPA, LIPE, LIPC, LDLR
14	gemfibrozil32 9 9	11.3	LPA, LPL, LIPC, LDLR, CETP, INS
15	epinephrine32 9 18 9	12.2	LIPE, LEP, ITGAM, INS, INSR, APC
16	linoleic acid32 18	10.2	LPL, LDLR, UCP1, CETP, ITGAM, APC
17	niacin32 9 9	11.2	NAMPT, LPA, LPL, LIPE, LDLR, CETP
18	ezetimibe32 9 9	11.2	LDLR, CETP, INS, APOA1, APOB, GPT
19	estradiol32 9 18 9	12.1	SERPINE1, RARB, CDK1, GTF2B, IL18, CCNB1
20	heparin32 9 18 9	12.0	LRP1, SERPINE1, LPA, LPL, LIPC, CETP
21	triiodothyronine32	9.0	RBP4, LIPC, LEP, UCP1, IGFBP1, IGFBP3
22	cyclosporin a32 42	9.9	LPL, LIPC, LEP, LDLR, CETP, ITGAM
23	ly29400232	8.9	RETN, LEP, CDK1, ITGAM, IL18, IL6
24	progesterone32 42 9 18 9	12.8	RBP4, RARB, UCP1, CDC25C, CDK1, FBN1
25	thiazolidinedione32	8.8	RETN, SERPINE1, LPL, LEP, UCP1, INS
26	phosphatidylinositol32	8.8	LRP1, RETN, NAMPT, LEP, UCP1, CDIPT
27	rosuvastatin32 34 9 9	11.8	LDLR, CETP, INS, IL6, APOA1, APOB
28	alpha tocopherol32	8.6	RBP4, LPL, RARB, LEP, LDLR, CETP
29	vitamin a32 9 18 9	11.4	RETN, RBP4, LPL, RARB, LIPC, LEP
30	bezafibrate32 9 9	10.4	SERPINE1, LPA, LPL, LIPC, LDLR, UCP1
31	cysteine32	8.4	LRP1, RBP4, LPA, LMNB1, RARB, LIPA
32	metformin32 34 9 9	11.3	RETN, SERPINE1, NAMPT, LPL, LEP, INS
33	nitric oxide32 9 18 9	11.2	RETN, LPA, LIPE, UCP1, ITGAM, FOXO3
34	tamoxifen32 34 9 9	11.2	LPL, LEP, LDLR, CETP, APOA1, APOB
35	p00332	8.2	RETN, SERPINE1, LIPC, LEP, UCP1, IGFBP3
36	testosterone32 9 18 9	11.1	LPL, RARB, LIPA, LIPC, CETP, CDK1
37	ribonucleic acid32	7.7	RBP4, NAMPT, RARB, LIPA, LIPE, UCP1
38	thyroxine32 18	8.7	RETN, RBP4, LPA, LPL, LIPC, LEP
39	fenofibrate32 9 9	9.5	RETN, SERPINE1, LPA, LPL, LIPC, LEP
40	oligonucleotide32	7.3	LRP1, NAMPT, RARB, LIPA, LIPE, CD4
41	norepinephrine32 9 18 9	10.2	RETN, LPL, LIPE, LEP, UCP1, INS
42	methotrexate32 34 42 9 9	11.1	SERPINE1, LEP, IL18, IL6, CCNB1, GPT
43	aspirin32 34 18	9.0	SERPINE1, LPA, LDLR, CETP, ITGAM, IL18
44	creatinine32	6.7	RETN, RBP4, NAMPT, LMNA, LEP, ITGAM
45	dexamethasone32 42 34 9 9	9.9	LRP1, RETN, RBP4, SERPINE1, NAMPT, LPL
46	alanine32	5.6	RETN, RBP4, LMNA, LDLR, MT-ND6, CETP
47	vegf32	5.2	LRP1, RETN, SERPINE1, LPA, LEP, CDK1
48	cycloheximide32	4.7	RETN, SERPINE1, LPL, RARB, LEP, LDLR
49	tyrosine32	4.5	LRP1, RETN, LMNB1, RARB, LIPC, YWHAH
50	serine32	3.6	LRP1, RBP4, SERPINE1, LMNA, LMNB2, ZMPSTE24

Cellular components related to lipodystrophy according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	lamin filament	GO:005638	10.6	LMNA, LMNB1, LMNB2
2	chylomicron	GO:042627	10.6	APOE, APOC3, APOB, APOA5, LPL
3	intermediate-density lipoprotein particle	GO:034363	10.6	APOB, APOC3, APOE
4	caveola	GO:005901	10.6	ADRB2, SLC27A1, PTRF, CAV1, CAV3, INSR
5	lipid particle	GO:005811	10.6	PLIN1, CAV1, FABP4, CIDEC, LIPE
6	low-density lipoprotein particle	GO:034362	10.6	APOE, APOB, APOA5, LDLR
7	very-low-density lipoprotein particle	GO:034361	10.5	APOE, APOC3, APOB, APOA5, APOA1, LPL
8	Golgi membrane	GO:000139	10.2	SREBF2, SREBF1, HLA-DQB1, HLA-DPB1, CAV1, CAV3
9	endoplasmic reticulum	GO:005783	10.2	ADIPOQ, EMD, SLC27A1, AGPAT2, AGPAT1, CRABP2
10	high-density lipoprotein particle	GO:034364	10.1	PON1, APOE, APOA5, APOA1, CETP, LIPC
11	endoplasmic reticulum membrane	GO:005789	10.1	HSD11B1, HMGCR, DIO1, SREBF1, AGPAT1, AGPAT2
12	clathrin-coated endocytic vesicle membrane	GO:030669	9.9	HLA-DRB1, HLA-DQB1, HLA-DPB1, APOB, LDLR
13	spherical high-density lipoprotein particle	GO:034366	9.9	PON1, APOC3, APOA1
14	membrane raft	GO:045121	9.7	ABCA1, TNFRSF1B, TNFRSF1A, TNF, CAV1, CAV3
15	nucleoplasm	GO:005654	9.6	PPARG, PPARA, PPARD, NR1H2, NR3C1, RPS6KA3
16	ER to Golgi transport vesicle membrane	GO:012507	9.4	SREBF2, SREBF1, HLA-DRB1, HLA-DQB1, HLA-DPB1, HLA-C
17	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.4	HLA-DRB1, HLA-DQB1, HLA-DPB1, HLA-C, HLA-B, HLA-A
18	cytosol	GO:005829	8.3	CCNB1, GPT, HTT, CAPN3, CAV1, AKT2
19	extracellular space	GO:005615	5.6	ADIPOQ, IGFBP3, IGF1, CARTPT, GH1, GHR
20	extracellular region	GO:005576	5.3	GHRL, GHRH, GHR, GH1, IGF1, IGFBP3

Biological processes related to lipodystrophy according to GeneDecks:

(show top 50)    (show all 82)

id	Name	GO ID	Score	Top Affiliating Genes
1	triglyceride biosynthetic process	GO:019432	10.8	GPAT2, AGPAT1, LPL, AGPAT2, LPIN1, LPIN2
2	response to cold	GO:009409	10.7	ADRB2, IL18, DIO2, ADRB3, PPARG, SLC27A1
3	negative regulation of cholesterol storage	GO:010887	10.7	NR1H2, PPARA, PPARG, ABCA1
4	glycerophospholipid biosynthetic process	GO:046474	10.6	AGPAT2, LPIN2, CDIPT, GPAT2, AGPAT1, LPIN1
5	triglyceride catabolic process	GO:019433	10.6	LIPC, APOB, APOC3, FABP4, PLIN1, APOA5
6	brown fat cell differentiation	GO:050873	10.6	PPARGC1A, PPARG, FABP4, SLC2A4, ADRB3, ADIPOQ
7	triglyceride metabolic process	GO:006641	10.6	CAV3, APOC3, CAV1, APOE, APOA5, LPL
8	Cdc42 protein signal transduction	GO:032488	10.6	APOA1, APOC3, APOE, ABCA1
9	cholesterol transport	GO:030301	10.6	APOA1, CETP, APOB, CAV1, LDLR
10	fatty acid metabolic process	GO:006631	10.6	PPARA, GHR, SLC27A1, LIPA, LPIN3, LPIN2
11	chylomicron remnant clearance	GO:034382	10.6	APOE, APOC3, LIPC, LMF1
12	phosphatidylcholine biosynthetic process	GO:006656	10.6	SLC27A1, LPIN3, APOA1, LPIN2, LPIN1
13	cholesterol efflux	GO:033344	10.5	APOE, APOA1, ABCA1, APOC3, CAV1
14	positive regulation of cholesterol efflux	GO:010875	10.5	PON1, ADIPOQ, LRP1, APOE, NR1H2, ABCA1
15	cellular lipid metabolic process	GO:044255	10.5	APOA1, LPIN2, APOA5, NR1H2, AGPAT1, AGPAT2
16	very-low-density lipoprotein particle remodeling	GO:034372	10.4	APOE, CETP, LIPC, LPL
17	high-density lipoprotein particle remodeling	GO:034375	10.4	APOE, APOC3, APOA1, CETP, LIPC
18	glucose homeostasis	GO:042593	10.4	INS, RBP4, SERPINE1, PPARG, CAV3, ADIPOQ
19	triglyceride homeostasis	GO:070328	10.4	ANGPTL4, APOC3, APOA5, APOA1, CETP, LIPC
20	phospholipid efflux	GO:033700	10.3	APOA1, APOC3, APOE, ABCA1
21	receptor-mediated endocytosis	GO:006898	10.3	LPA, LDLR, CETP, APOB, APOE, ADRB2
22	negative regulation of MAP kinase activity	GO:043407	10.3	APOE, GBA, ADIPOQ, HMGCR, CAV3
23	reverse cholesterol transport	GO:043691	10.3	ABCA1, CETP, LIPC, APOA1, APOC3, APOE
24	cellular response to insulin stimulus	GO:032869	10.3	ADIPOQ, INSR, AKT2, GHR, SLC2A4, PPARG
25	MAPK cascade	GO:000165	10.3	YWHAB, IL18, CDK1, INS, TNF, CAV1
26	positive regulation of glucose import	GO:046326	10.2	INS, INSR, IGF1, AKT2, ADIPOQ
27	cholesterol metabolic process	GO:008203	10.2	CETP, LDLR, LEP, LIPC, LIPE, APOA1
28	cholesterol homeostasis	GO:042632	10.2	LIPC, LDLR, CETP, APOA1, APOA5, APOB
29	negative regulation of inflammatory response	GO:050728	10.2	TNFRSF1B, TNFRSF1A, GHRL, ADRB2, APOE, ADIPOQ
30	lipoprotein metabolic process	GO:042157	10.2	APOA5, APOE, APOC3, PPARA, LPA, LPL
31	lipid metabolic process	GO:006629	10.1	PPARD, PLIN1, ABCA1, CETP, LPL, LPIN2
32	response to ethanol	GO:045471	10.0	RBP4, CDK1, INSR, CCL2, TNFRSF1A, SLC2A4
33	negative regulation of smooth muscle cell migration	GO:014912	9.9	ADIPOQ, IGFBP3, LRP1, SERPINE1
34	response to activity	GO:014823	9.9	CDK1, NR3C1, TNF, INSR, CCL2
35	negative regulation of macrophage derived foam cell differentiation	GO:010745	9.8	ADIPOQ, PPARG, ABCA1, CRP, NR1H2, PPARA
36	G-protein coupled receptor signaling pathway	GO:007186	9.7	CCL2, C3, ABCA1, SST, GHRL, CARTPT
37	response to drug	GO:042493	9.4	CAV1, FAS, TNF, SST, PPARG, LTA
38	apoptotic process	GO:006915	9.4	LMNB1, CAPN3, AKT2, TNF, TNFRSF1A, PSMB8
39	transcription initiation from RNA polymerase II promoter	GO:006367	9.4	SERPINE1, RARB, GTF2B, PPARGC1A, PPARG, PPARA
40	positive regulation of MAPK cascade	GO:043410	9.3	INS, INSR, LEP, IL6, IGFBP3, IGF1
41	small molecule metabolic process	GO:044281	9.3	INS, APOA1, APOA5, APOB, CETP, CDIPT
42	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	9.3	GHRH, IGF1, IGFBP3, GH1
43	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.3	CD4, INS, IGF1, GH1, GHR, ADIPOQ
44	response to glucocorticoid stimulus	GO:051384	9.2	ADIPOQ, PLAT, CAV1, SERPINE1, CCL2, GHR
45	negative regulation of apoptotic process	GO:043066	9.0	ANGPTL4, INS, CAPN3, GHRL, HMGA2, TNF
46	anti-apoptosis	GO:006916	9.0	TNF, HTT, IGF1R, CCL2, FAS, NR3C1
47	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.9	FOXO3, RARB, IL6, SERPINE1, IGF1, PPARA
48	response to hypoxia	GO:001666	8.8	TNFRSF1A, PPARA, CAV1, ANGPTL4, CRP, LTA
49	signal transduction	GO:007165	8.6	NAMPT, CD4, FAS, RPS6KA3, ANGPTL4, CRABP2
50	cytokine-mediated signaling pathway	GO:019221	8.4	HLA-A, PSMB8, TNFRSF1A, HLA-DRB1, HLA-DQB1, HLA-DPB1

Molecular functions related to lipodystrophy according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	thyroxine 5-deiodinase activity	GO:004800	10.6	DIO3, DIO2, DIO1
2	steroid hormone receptor activity	GO:003707	10.3	NR1H2, PPARD, PPARA, PPARG, RARB
3	cholesterol transporter activity	GO:017127	10.2	CETP, APOA1, APOB, ABCA1
4	apolipoprotein binding	GO:034185	10.1	ABCA1, LIPC, LPA, LRP1
5	insulin-like growth factor receptor binding	GO:005159	10.1	IGF1, INSR, INS, YWHAH, YWHAG
6	protein domain specific binding	GO:019904	10.1	YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ
7	enzyme binding	GO:019899	9.9	PPARG, CAV1, APOB, APOA5, APOA1, CD4
8	hormone activity	GO:005179	9.9	ADIPOQ, SST, GH1, IGF1, INS, LEP
9	protease binding	GO:002020	9.9	SERPINE1, INS, TNF, TNFRSF1A, POLG
10	heparin binding	GO:008201	9.8	CCL2, APOE, APOB, APOA5, LIPC, LPL
11	insulin-like growth factor I binding	GO:031994	9.8	IGFBP3, IGF1R, INSR
12	cholesterol binding	GO:015485	9.5	ABCA1, CRP, CAV1, APOC3, APOA1, CETP
13	receptor binding	GO:005102	9.2	GBA, ADIPOQ, C3, CXCL12, LTA, HLA-B
14	protein binding	GO:005515	4.3	ADIPOQ, SREBF2, SREBF1, PTRF, TNFRSF1B, TNFRSF1A