MCID: LPG001
MIFTS: 25

Lipogranulomatosis malady

Summaries for Lipogranulomatosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Farber disease (also known as Farber\'s lipogranulomatosis, ceramidase deficiency, \"Fibrocytic... more...

MalaCards: Lipogranulomatosis, also known as erdheim-chester disease, is related to farber lipogranulomatosis and niemann-pick disease. An important gene associated with Lipogranulomatosis is ASAH1 (N-acylsphingosine amidohydrolase (acid ceramidase) 1), and among its related pathways are Lysosome and sphingosine and sphingosine-1-phosphate metabolism. The compounds n-oleoylethanolamine and 4-methylumbelliferyl-beta-d-glucoside have been mentioned in the context of this disorder. Affiliated tissues include liver.

Aliases & Classifications for Lipogranulomatosis

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60UMLS, 42NIH Rare Diseases, 44Novoseek
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Aliases & Descriptions:

lipogranulomatosis 42 44
erdheim-chester disease 60


Related Diseases for Lipogranulomatosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lipogranulomatosis:



Diseases related to lipogranulomatosis

Clinical Features for Lipogranulomatosis

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Drugs & Therapeutics for Lipogranulomatosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Lipogranulomatosis

Search NIH Clinical Center for Lipogranulomatosis

Search CenterWatch for Lipogranulomatosis

Genetic Tests for Lipogranulomatosis

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Anatomical Context for Lipogranulomatosis

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32MalaCards
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MalaCards organs/tissues related to Lipogranulomatosis:

32
Liver

Animal Models for Lipogranulomatosis or affiliated genes

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Publications for Lipogranulomatosis

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Genetic Variations for Lipogranulomatosis

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Expression for genes affiliated with Lipogranulomatosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipogranulomatosis

Search GEO for disease gene expression data for Lipogranulomatosis.

Pathways for genes affiliated with Lipogranulomatosis

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29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Lipogranulomatosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ASAH1, GALC, PSAP
29.1ACER1, ACER2, ASAH2, ASAH1
3
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8.6ACER1, ACER3, ACER2, ASAH2, ASAH1
4
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8.0ASAH1, ASAH2, ACER2, ACER3, ACER1, GALC

Compounds for genes affiliated with Lipogranulomatosis

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44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR
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Compounds related to Lipogranulomatosis according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1n-oleoylethanolamine44 2411.1ASAH1, ASAH2
24-methylumbelliferyl-beta-d-glucoside4410.0PSAP, GALC
3psychosine4410.0GALC, PSAP
4galactosylceramide449.9PSAP, GALC
5glycolipid449.9GALC, PSAP
6ceranib 1599.8ACER1, ASAH2, ASAH1
7ceramide449.5PSAP, ASAH2, ASAH1
8stearic acid44 11 2411.4ACER1, ACER2, ASAH2, ASAH1
9palmitic acid28 11 2411.3ACER1, ACER2, ASAH2, ASAH1
10myristic acid44 11 2411.3ASAH1, ASAH2, ACER2, ACER1
11sphinganine44 2410.2ACER2, ACER3
12arachidonic acid44 28 11 2412.1ASAH1, ASAH2, ACER2, ACER1
13sphingosine44 11 2411.1ASAH1, ASAH2, ACER2, ACER1, PSAP
14glucosylceramide44 249.8PSAP, GALC, ACER1, ACER2, ASAH2, ASAH1
15dihydroceramide44 249.6ASAH1, ASAH2, ACER2, ACER3, ACER1, GALC

GO Terms for genes affiliated with Lipogranulomatosis

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16Gene Ontology
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Cellular components related to Lipogranulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to Golgi membraneGO:0301739.5ACER2, ACER3
2lysosomal lumenGO:0432029.3ASAH1, GALC, PSAP

Biological processes related to Lipogranulomatosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of lipid metabolic processGO:0192169.8ACER1, PSAP
2glycosphingolipid metabolic processGO:0066879.3PSAP, GALC, ASAH2, ASAH1
3sphingosine biosynthetic processGO:0465129.2ACER2, ACER3, ACER1
4ceramide metabolic processGO:0066729.1ACER3, ACER2, ASAH2, ASAH1
5sphingolipid biosynthetic processGO:0301488.9ACER2, ACER3, ACER1
6sphingolipid metabolic processGO:0066658.1ASAH1, ASAH2, ACER2, ACER3, ACER1, GALC
7small molecule metabolic processGO:0442817.9PSAP, GALC, ACER1, ACER3, ACER2, ASAH2

Molecular functions related to Lipogranulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dihydroceramidase activityGO:0716339.7ACER2, ACER1
2ceramidase activityGO:0170408.8ASAH1, ASAH2, ACER2, ACER1

Products for genes affiliated with Lipogranulomatosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lipogranulomatosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet