MCNS
MCID: LPD004
MIFTS: 51

Lipoid Nephrosis (MCNS) malady

Rare diseases, Nephrological diseases categories
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Summaries for Lipoid Nephrosis

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Sources:
43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Minimal change disease is a kidney disorder that can lead to nephrotic syndrome, although the nephrons of the kidney look normal under a regular microscope. the most common symptom is swelling around the eyes, face, abdomen, and legs. other features include poor appetite, weight gain, and a foamy appearance of the urine. the cause of minimal change disease is unknown, but it may occur following an allergic reaction, immunization, or viral infection. treatment may involve the use of steroids such as prednisone. children often respond better to this therapy than adults. those who experience repeated relapses may benefit from the use of cytotoxic therapy, including cyclophosphamide, cyclosporine or chlorambucil. last updated: 8/4/2011

MalaCards: Lipoid Nephrosis, also known as minimal change disease, is related to nephrotic syndrome and proteinuria. An important gene associated with Lipoid Nephrosis is IL13 (interleukin 13), and among its related pathways are Selected targets of C EBPalpha and Response to elevated platelet cytosolic Ca2+. The compounds kp-1019 and bismuth have been mentioned in the context of this disorder. Affiliated tissues include kidney, eye and monocytes, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Wikipedia:65 Minimal Change Disease (MCD, also known as Nil Lesions or Nil Disease (lipoid nephrosis)) is a disease... more...

Aliases & Classifications for Lipoid Nephrosis

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8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

lipoid nephrosis 8
minimal change disease 8 43
nephrotic syndrome with lesion of minimal change glomerulonephritis 8
nephrotic syndrome with lesion of minimal change nephrotic syndrome 8
idiopathic minimal change nephrotic syndrome 43
nephrotic syndrome, minimal change 62
glomerulonephritis, minimal change 62
nephrotic syndrome minimal change 45
minimal change glomerulonephritis 8
minimal change nephrotic syndrome 43
minimal change glomerulopathy 43
mcns 43


External Ids:

Disease Ontology8 DOID:10966
SNOMED-CT58 44785005, 197592009
MeSH35 D009402

Related Diseases for Lipoid Nephrosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lipoid Nephrosis:



Diseases related to lipoid nephrosis

Symptoms for Lipoid Nephrosis

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Drugs & Therapeutics for Lipoid Nephrosis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Lipoid Nephrosis

Search NIH Clinical Center for Lipoid Nephrosis

Genetic Tests for Lipoid Nephrosis

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Anatomical Context for Lipoid Nephrosis

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33MalaCards
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MalaCards organs/tissues related to Lipoid Nephrosis:

33
Kidney, Eye, Monocytes, T cells, Bone

Animal Models for Lipoid Nephrosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Lipoid Nephrosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.6ALB, IL13, IL10
2MP:00053818.5ALB, IL13, IL10
3MP:00053768.0ALB, IL13, IL10, TF
4MP:00107687.7TF, IL10, IL13, ALB

Publications for Lipoid Nephrosis

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52PubMed
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Articles related to Lipoid Nephrosis:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Interleukin 10 inhibits vascular permeability factor release by peripheral blood mononuclear cells in patients with lipoid nephrosis. (9041534)
1997
2
Effect of lipoid nephrosis cytokine on glomerular sulfated compounds and albuminuria. (8580016)
1995
3
Proteinuria selectivity index--prognostic value in lipoid nephrosis and related diseases. (8247178)
1993
4
Recombinant granulocyte-macrophage colony-stimulating factor modulates in vitro function of the peripheral blood mononuclear cells in lipoid nephrosis. (8342574)
1993
5
Renin activity and aldosterone level in the plasma of children with lipoid nephrosis]. (2251209)
1990
6
Effect of methylprednisolone pulse therapy on cellular immunity abnormalities in a patient with lipoid nephrosis. (2077423)
1990
7
Ibuprofen-associated lipoid nephrosis without interstitial nephritis. (2741936)
1989
8
A transient monocyte defective function in idiopathic nephrotic syndrome (lipoid nephrosis). (3170113)
1988
9
Evaluation of T colony-stimulating factor in patients with lipoid nephrosis. (3484545)
1986
10
Impaired T-lymphocyte colony formation in lipoid nephrosis. (3878248)
1985
11
Impaired cellular immune responses in adult lipoid nephrosis patients. (4017301)
1985
12
HLA-DR 7 in adult lipoid nephrosis patients. Significant difference according to the age of onset. (6603586)
1983
13
Adult onset lipoid nephrosis is not DR7 associated. (6415866)
1983
14
Allergy and lipoid nephrosis. (6404133)
1983
15
Effect of thymic humoral factor on a local graft-versus-host reaction of lymphocytes in patients with lipoid nephrosis. (6984140)
1982
16
In vitro lymphocyte dysfunction in lipoid nephrosis mediated by suppressor cells. (6218418)
1982
17
Is lipoid nephrosis an "allergic" disease? (6217600)
1982
18
Lipoid nephrosis appearing as acute oliguric renal failure. (7362359)
1980
19
Congenital lipoid nephrosis with left renal vein thrombosis and Chiari's syndrome. (468879)
1979
20
Lipoid nephrosis and focal glomerulosclerosis. (355987)
1978
21
Nephrotic syndrome with minimal glomerular lesions (lipoid nephrosis) in an adult diabetic patient. (576799)
1977
22
Hodgkin's disease and lipoid nephrosis. (67327)
1977
23
Postural proteinuria and lipoid nephrosis of 58 years' duration. (1009389)
1976
24
Letter: Lipoid nephrosis and focal glomerulosclerosis in a patient with polymyositis. (48714)
1975
25
Lipoid nephrosis and focal sclerosis distinct entities or spectrum of disease. (4853015)
1974
26
Minimal change and focal sclerotic lesions in lipoid nephrosis. (4368918)
1974
27
Natural history of childhood lipoid nephrosis. (4713549)
1973
28
Glomerular localisation of IgE in lipoid nephrosis. (4122790)
1973
29
Lipoid nephrosis: an approach to the clinicopathologic analysis and dismemberment of idiopathic nephrotic syndrome with minimal glomerular changes. (4725964)
1973
30
Lipoid nephrosis: a reassessment. (4620918)
1973
31
Lipoid nephrosis in Hodgkin's disease. (4554878)
1972
32
Histometrical glomerular studies on the kidneys in multiple myeloma and in acute membranous glomerulonephritis (lipoid nephrosis). (5145535)
1971
33
Intraglomerular fibrin, platelet aggregation, and subendothelial deposits in lipoid nephrosis. (4189232)
1970
34
Lipoid nephrosis in 31 adult patients: renal biopsy study by light, electron, and fluorescence microscopy with experience in treatment. (5426747)
1970
35
Myxovirus-like particles in lipoid nephrosis. (5800520)
1969
36
An autopsy case of renal disease similar to lipoid nephrosis modified by steroid treatment. (4289007)
1966
37
SERUM LEVELS OF BETA-1C GLOBULIN, A COMPLEMENT COMPONENT, IN THE NEPHRITIDES, LIPOID NEPHROSIS, AND OTHER CONDITIONS. (14201535)
1964
38
The fine structure of the glomerulus in membranous glomerulonephritis (lipoid nephrosis) in adults. (13670133)
1959
39
Aminoaciduria in the course of lipoid nephrosis in children; the influence of ACTH. (13636858)
1959
40
Hormonal treatment of lipoid nephrosis]. (13537809)
1958
41
Heparin in lipoid nephrosis; observations of the effects on edema, proteinuria, serum proteins, lipids and lipoproteins. (13196959)
1954
42
Lipoid nephrosis in children; physiopathological study and therapeutic indications]. (13218770)
1954
43
ACTH in lipoid nephrosis]. (13102710)
1953
44
Plasma protein patterns in a case of lipoid nephrosis; an electrophoretic study. (13084095)
1953
45
Histochemical distribution of glycogen II. In the kidneys of patients with different pathological conditions, especially those with lipoid nephrosis. (14818524)
1951
46
Chronic lipoid nephrosis in retrospect. (15425770)
1950
47
Chronic Lipoid Nephrosis in Retrospect. (21407705)
1949
48
The morphological backgrounds of genuine lipoid nephrosis. (18884732)
1948
49
Lipoid nephrosis with necropsy findings. (18860780)
1948
50
A CASE OF LIPOID NEPHROSIS. (20776077)
1931

Variations for Lipoid Nephrosis

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Expression for genes affiliated with Lipoid Nephrosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipoid Nephrosis

Search GEO for disease gene expression data for Lipoid Nephrosis.

Pathways for genes affiliated with Lipoid Nephrosis

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50PathCards, 12EMD Millipore, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN
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Compounds for genes affiliated with Lipoid Nephrosis

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45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
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Compounds related to Lipoid Nephrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1kp-1019459.8TF, ALB
2bismuth45 2410.8TF, ALB
3mycophenolic acid45 51 1111.8ALB, IL13
4gelfoam459.8ALB, TF
5ovomucoid459.8TF, IL13
6suprofen45 1110.7ALB, TF
7penicillin459.7IL13, TF
8antipyrine45 1110.7ALB, TF
9dtpa459.7ALB, TF
10glutaraldehyde459.6TF, ALB
11alpha-galactosylceramide459.5IL10, IL13
12mip 1alpha459.5IL10, IL13
13glatiramer acetate45 1110.5IL13, IL10
14praziquantel45 1110.5IL13, IL10
15as 10145 6110.5IL10, IL13
16il-12459.5IL13, IL10
17clomipramine45 51 1111.5IL10, ALB
18cortisone45 2410.5IL10, IL13
19indoleamine459.5IL10, IL13
20montelukast45 51 29 1112.5IL13, IL10
21streptomycin51 45 1111.5TF, IL10
22enalapril45 51 1111.4IL10, ALB
23groalpha459.4IL13, IL10
24triamcinolone acetonide45 2910.4IL10, TF
25gm-csf45 2910.4IL13, IL10
26salbutamol45 51 29 24 1113.4IL13, IL10
27rolipram45 61 2911.3IL13, IL10
28diclofenac45 29 51 1112.3IL13, ALB
29il 10459.3IL13, IL10
308-isoprostane459.3IL10, TF
31alpha tocopherol459.2IL13, ALB, TF
32mycophenolate mofetil45 51 1111.2IL10, ALB
33vitamin a45 24 1111.2ALB, IL13, TF
34fluoxetine45 51 29 1112.2IL10, ALB
35acetaldehyde29 45 2411.2TF, IL10
36tarc459.1IL10, IL13
37lactate459.1IL13, TF, ALB
38ribavirin45 51 1111.0IL10, TF
39calcitriol45 61 24 1112.0IL13, ALB, IL10
40hydrocortisone45 3 61 1111.9IL13, IL10, TF
41cyclophosphamide45 51 1110.9IL10, IL13, TF
42methotrexate51 45 1110.9TF, ALB, IL10
43ivig458.8IL10, ALB
44cyclosporin a45 29 6110.8IL10, IL13, TF
45pge2458.8TF, IL10, IL13
46prednisolone45 29 1110.4TF, ALB, IL13, IL10
47thyroxine45 249.4IL10, ALB, TF, IL13
48tacrolimus45 51 1110.4IL13, TF, ALB, IL10
49histamine45 29 2410.4ALB, IL13, IL10, TF
50aspartate458.4IL10, IL13, ALB, TF

GO Terms for genes affiliated with Lipoid Nephrosis

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16Gene Ontology
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Cellular components related to Lipoid Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.0ALB, TF
2extracellular regionGO:0055768.8ALB, IL13, TF
3extracellular spaceGO:0056157.9ALB, IL13, IL10, TF

Biological processes related to Lipoid Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retina homeostasisGO:0018959.3ALB, TF
2platelet degranulationGO:0025769.2ALB, TF
3cell-cell signalingGO:0072679.1IL13, IL10
4platelet activationGO:0301689.0ALB, TF

Molecular functions related to Lipoid Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL13, IL10

Products for genes affiliated with Lipoid Nephrosis

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Sources for Lipoid Nephrosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet