MCNS
MCID: LPD004
MIFTS: 42

Lipoid Nephrosis (MCNS) malady

Nephrological diseases category

Summaries for Lipoid Nephrosis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Minimal change disease is a kidney disorder that can lead to nephrotic syndrome, although the nephrons of the kidney look normal under a regular microscope. the most common symptom is swelling around the eyes, face, abdomen, and legs. other features include poor appetite, weight gain, and a foamy appearance of the urine. the cause of minimal change disease is unknown, but it may occur following an allergic reaction, immunization, or viral infection. treatment may involve the use of steroids such as prednisone. children often respond better to this therapy than adults. those who experience repeated relapses may benefit from the use of cytotoxic therapy, including cyclophosphamide, cyclosporine or chlorambucil. last updated: 8/4/2011

MalaCards: Lipoid Nephrosis, also known as minimal change disease, is related to glomerulonephritis and nephrotic syndrome. An important gene associated with Lipoid Nephrosis is IL13 (interleukin 13), and among its related pathways are Cytokine Network and Cytokines and Inflammatory Response. The compounds prednisolone and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include kidney, eye and monocytes.

Wikipedia:63 Minimal Change Disease (also known as Nil Lesions or Nil Disease (lipoid nephrosis)) is a disease of the... more...

Aliases & Classifications for Lipoid Nephrosis

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

lipoid nephrosis 8
minimal change disease 8 42
nephrotic syndrome with lesion of minimal change glomerulonephritis 8
nephrotic syndrome with lesion of minimal change nephrotic syndrome 8
idiopathic minimal change nephrotic syndrome 42
nephrotic syndrome, minimal change 60
glomerulonephritis, minimal change 60
nephrotic syndrome minimal change 44
minimal change glomerulonephritis 8
minimal change nephrotic syndrome 42
minimal change glomerulopathy 42
mcns 42


External Ids:

Disease Ontology8 DOID:10966
SNOMED-CT56 197592009, 44785005
MeSH34 D009402

Related Diseases for Lipoid Nephrosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lipoid Nephrosis:



Diseases related to lipoid nephrosis

Clinical Features for Lipoid Nephrosis

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Drugs & Therapeutics for Lipoid Nephrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Lipoid Nephrosis

Search NIH Clinical Center for Lipoid Nephrosis

Search CenterWatch for Lipoid Nephrosis

Genetic Tests for Lipoid Nephrosis

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Anatomical Context for Lipoid Nephrosis

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32MalaCards
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MalaCards organs/tissues related to Lipoid Nephrosis:

32
Kidney, Eye, Monocytes, T cells, Bone

Animal Models for Lipoid Nephrosis or affiliated genes

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Publications for Lipoid Nephrosis

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50PubMed
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Articles related to Lipoid Nephrosis:

(show top 50)    (show all 114)
idTitleAuthorsYear
1
Cytokine mRNA profile in lipoid nephrosis: evidence for increased IL-8 mRNA stability. (12138264)
2002
2
Anti-interleukin 8 antibody abolishes effects of lipoid nephrosis cytokine. (9686956)
1998
3
Changing perspective of lipoid nephrosis in Iranian children. (9874333)
1998
4
Effect of lipoid nephrosis cytokine on glomerular sulfated compounds and albuminuria. (8580016)
1995
5
Decreased release of IL-10 by monocytes from patients with lipoid nephrosis. (8536379)
1995
6
Proteinuria selectivity index--prognostic value in lipoid nephrosis and related diseases. (8247178)
1993
7
Acquired factor VIII autoantibody (AAb) in the course of lipoid nephrosis. (8302482)
1993
8
Inner ear damage due to lipoid nephrosis. (8357609)
1993
9
Renin activity and aldosterone level in the plasma of children with lipoid nephrosis]. (2251209)
1990
10
Interferon and lipoid nephrosis. (2458041)
1988
11
Impaired T-lymphocyte colony formation in lipoid nephrosis. (3878248)
1985
12
Impaired delayed hypersensitivity in lipoid nephrosis. (6462316)
1984
13
HLA-DR 7 in adult lipoid nephrosis patients. Significant difference according to the age of onset. (6603586)
1983
14
Adult onset lipoid nephrosis is not DR7 associated. (6415866)
1983
15
Allergy and lipoid nephrosis. (6404133)
1983
16
Effect of thymic humoral factor on a local graft-versus-host reaction of lymphocytes in patients with lipoid nephrosis. (6984140)
1982
17
In vitro lymphocyte dysfunction in lipoid nephrosis mediated by suppressor cells. (6218418)
1982
18
Impaired local graft-versus-host reaction in lipoid nephrosis. (6981777)
1982
19
Lipoid nephrosis in the elderly. (7394611)
1980
20
Congenital lipoid nephrosis with left renal vein thrombosis and Chiari's syndrome. (468879)
1979
21
Lipoid nephrosis and focal glomerulosclerosis. (355987)
1978
22
Postural proteinuria and lipoid nephrosis of 58 years' duration. (1009389)
1976
23
Minimal change and focal sclerotic lesions in lipoid nephrosis. (4368918)
1974
24
Proceedings: Significance of 'focal sclerosis' in lipoid nephrosis. (4853850)
1974
25
Adult lipoid nephrosis: clinicopathological correlations. (4368384)
1974
26
Pathogenesis of lipoid nephrosis: a disorder of T-cell function. (4140273)
1974
27
Natural history of childhood lipoid nephrosis. (4713549)
1973
28
Lipoid nephrosis: a reassessment. (4620918)
1973
29
Intraglomerular fibrin, platelet aggregation, and subendothelial deposits in lipoid nephrosis. (4189232)
1970
30
Lipoid nephrosis in 31 adult patients: renal biopsy study by light, electron, and fluorescence microscopy with experience in treatment. (5426747)
1970
31
Myxovirus-like particles in lipoid nephrosis. (5800520)
1969
32
Cobalt-induced hypothyroidism and polycythemia in lipoid nephrosis. (5710037)
1968
33
MUCOPROTEINS IN BLOOD AND URINE IN LIPOID NEPHROSIS IN CHILDREN. (14343802)
1965
34
SERUM LEVELS OF BETA-1C GLOBULIN, A COMPLEMENT COMPONENT, IN THE NEPHRITIDES, LIPOID NEPHROSIS, AND OTHER CONDITIONS. (14201535)
1964
35
Use of combined hormone and mechlorethamine (nitrogen mustard) therapy in lipoid nephrosis. (13520143)
1958
36
A hitherto undescribed vulnerability of the juxtamedullary glomeruli in lipoid nephrosis. (13426687)
1957
37
Lipoid nephrosis in children; physiopathological study and therapeutic indications]. (13218770)
1954
38
Plasma protein patterns in a case of lipoid nephrosis; an electrophoretic study. (13084095)
1953
39
Malarial therapy in lipoid nephrosis. (14918441)
1952
40
Methionine in lipoid nephrosis; a therapeutic trial. (12987080)
1952
41
Histochemical distribution of glycogen II. In the kidneys of patients with different pathological conditions, especially those with lipoid nephrosis. (14818524)
1951
42
Qualitative and quantitative changes in the plasma proteins of lipoid nephrosis demonstrated by electrophoresis. (14850819)
1951
43
Lipoid nephrosis during and after pregnancy. (14848712)
1951
44
Chronic lipoid nephrosis in retrospect. (15425770)
1950
45
Electrophoretic studies of plasma and urinary proteins in children with lipoid nephrosis. (18101060)
1948
46
Lipoid nephrosis; clinical and biochemical studies of 40 children, with 10 necropsies. (18866957)
1948
47
Diffuse glomerulonephritis; suggested classification with special reference to so-called lipoid nephrosis. (18859429)
1948
48
Lipoid nephrosis; a review of the disease with report of case. (21008695)
1946
49
NOTE ON A CASE OF LIPOID NEPHROSIS: PART I.-CLINICAL AND BIOCHEMICAL. (20775636)
1930
50
Lipoid Nephrosis. (19969877)
1929

Genetic Variations for Lipoid Nephrosis

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Expression for genes affiliated with Lipoid Nephrosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipoid Nephrosis

Search GEO for disease gene expression data for Lipoid Nephrosis.

Pathways for genes affiliated with Lipoid Nephrosis

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51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Lipoid Nephrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4IL10, IL13
29.4IL13, IL10
39.4IL10, IL13
4
Hide members
9.1ALB, TF
59.1ALB, TF
68.9IL10, IL13, TF

Compounds for genes affiliated with Lipoid Nephrosis

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Lipoid Nephrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1prednisolone44 28 1112.5IL13
2cyclosporin a44 28 5912.2TF
3gm-csf44 2811.2IL10
4aspartate4410.1ALB
5ovomucoid449.9TF, IL13
6penicillin449.9TF, IL13
7alpha-galactosylceramide449.8IL10, IL13
8mip 1alpha449.8IL13, IL10
9glatiramer acetate44 1110.8IL10, IL13
10praziquantel44 1110.8IL13, IL10
11as 10159 4410.8IL13, IL10
12streptomycin44 1110.8TF, IL10
13il-12449.8IL13, IL10
14cortisone44 2410.7IL10, IL13
15indoleamine449.7IL13, IL10
16montelukast44 49 28 1112.7IL13, IL10
17groalpha449.7IL13, IL10
18triamcinolone acetonide44 2810.7TF, IL10
19salbutamol44 49 28 11 2413.7IL10, IL13
208-isoprostane449.6IL10, TF
21Bismuth Subsalicylate119.6ALB, TF
22kp-1019449.6ALB, TF
23bismuth44 2410.6ALB, TF
24gelfoam449.6TF, ALB
25suprofen44 1110.5ALB, TF
26il 10449.5IL13, IL10
27mycophenolic acid44 49 1111.5ALB, IL13
28antipyrine44 1110.5ALB, TF
29dtpa449.5TF, ALB
30tarc449.5IL13, IL10
31acetaldehyde44 28 2411.4TF, IL10
32glutaraldehyde449.4ALB, TF
33ccl344 2810.4IL13, IL10
34clomipramine44 49 1111.4ALB, IL10
35enalapril44 49 1111.4IL10, ALB
36cyclophosphamide44 49 1111.3TF, IL13, IL10
37mycophenolate mofetil44 49 1111.3ALB, IL10
38ribavirin44 49 1111.2IL10, TF
39fluoxetine49 44 28 1112.2ALB, IL10
40diclofenac44 28 49 1112.2IL13, ALB
41pge2449.1IL13, TF, IL10
42alpha tocopherol449.1ALB, TF, IL13
43vitamin a44 11 2411.1ALB, IL13, TF
44calcitriol44 59 11 2412.0IL10, ALB, IL13
45methotrexate44 49 1110.9TF, IL10, ALB
46lactate448.9TF, IL13, ALB
47ivig448.7ALB, IL10
48thyroxine44 249.5IL10, TF, ALB, IL13
49tacrolimus44 49 1110.5ALB, IL10, IL13, TF
50histamine44 28 2410.5ALB, IL10, TF, IL13

GO Terms for genes affiliated with Lipoid Nephrosis

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16Gene Ontology
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Biological processes related to Lipoid Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:0025769.1ALB, TF

Products for genes affiliated with Lipoid Nephrosis

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Sources for Lipoid Nephrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet