MCNS
MCID: LPD004
MIFTS: 40

Lipoid Nephrosis (MCNS) malady

Nephrological category

Summaries for Lipoid Nephrosis

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Minimal change disease is a kidney disorder that can lead to nephrotic syndrome, although the nephrons of the kidney look normal under a regular microscope. the most common symptom is swelling around the eyes, face, abdomen, and legs. other features include poor appetite, weight gain, and a foamy appearance of the urine. the cause of minimal change disease is unknown, but it may occur following an allergic reaction, immunization, or viral infection. treatment may involve the use of steroids such as prednisone. children often respond better to this therapy than adults. those who experience repeated relapses may benefit from the use of cytotoxic therapy, including cyclophosphamide, cyclosporine or chlorambucil. last updated: 8/4/2011

MalaCards: Lipoid Nephrosis, also known as minimal change disease, is related to nephritis and tetanus. An important gene associated with Lipoid Nephrosis is IL13 (interleukin 13), and among its related pathways are Cytokine Network and Cytokines and Inflammatory Response. The compounds prednisolone and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include kidney, monocytes and t cells.

Wikipedia:64 Minimal Change Disease (also known as Nil Lesions or Nil Disease (lipoid nephrosis)) is a disease of the... more...

Aliases & Classifications for Lipoid Nephrosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Aliases & Descriptions:

lipoid nephrosis 8
minimal change disease 8 43
nephrotic syndrome with lesion of minimal change glomerulonephritis 8
nephrotic syndrome with lesion of minimal change nephrotic syndrome 8
idiopathic minimal change nephrotic syndrome 43
nephrotic syndrome, minimal change 61
glomerulonephritis, minimal change 61
nephrotic syndrome minimal change 45
minimal change glomerulonephritis 8
minimal change nephrotic syndrome 43
minimal change glomerulopathy 43
mcns 43


External Ids:

Disease Ontology8 DOID:10966
SNOMED-CT57 197592009, 44785005
MeSH35 D009402

Related Diseases for Lipoid Nephrosis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lipoid Nephrosis:



Diseases related to lipoid nephrosis

Clinical Features for Lipoid Nephrosis

Drugs & Therapeutics for Lipoid Nephrosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Lipoid Nephrosis

Drug clinical trials:

Search ClinicalTrials for Lipoid Nephrosis

Search NIH Clinical Center for Lipoid Nephrosis

Search CenterWatch for Lipoid Nephrosis

Genetic Tests for Lipoid Nephrosis

Anatomical Context for Lipoid Nephrosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Lipoid Nephrosis:

33
Kidney, Monocytes, T cells

Animal Models for Lipoid Nephrosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Lipoid Nephrosis

Sources:
51PubMed
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Articles related to Lipoid Nephrosis:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Cytokine mRNA profile in lipoid nephrosis: evidence for increased IL-8 mRNA stability. (12138264)
2002
2
T-cell lineage acute lymphoblastic leukemia with chromosome 5 abnormality in a patient with Crohn's disease and lipoid nephrosis. (10834511)
2000
3
Anti-interleukin 8 antibody abolishes effects of lipoid nephrosis cytokine. (9686956)
1998
4
Interleukin 12 upregulates the release of vascular permeability factor by peripheral blood mononuclear cells from patients with lipoid nephrosis. (9578066)
1998
5
Changing perspective of lipoid nephrosis in Iranian children. (9874333)
1998
6
Decreased release of IL-10 by monocytes from patients with lipoid nephrosis. (8536379)
1995
7
Acquired factor VIII autoantibody (AAb) in the course of lipoid nephrosis. (8302482)
1993
8
Renin activity and aldosterone level in the plasma of children with lipoid nephrosis]. (2251209)
1990
9
Effect of methylprednisolone pulse therapy on cellular immunity abnormalities in a patient with lipoid nephrosis. (2077423)
1990
10
A transient monocyte defective function in idiopathic nephrotic syndrome (lipoid nephrosis). (3170113)
1988
11
An overlapping syndrome of IgA nephropathy and lipoid nephrosis. (3538845)
1986
12
Impaired T-lymphocyte colony formation in lipoid nephrosis. (3878248)
1985
13
Impaired delayed hypersensitivity in lipoid nephrosis. (6462316)
1984
14
Alterations of T cell subpopulations in childhood lipoid nephrosis and its relation to immunosuppressive treatment. (6335580)
1984
15
Is lipoid nephrosis an "allergic" disease? (6217600)
1982
16
Impaired local graft-versus-host reaction in lipoid nephrosis. (6981777)
1982
17
Fenoprofen nephropathy: lipoid nephrosis and interstitial nephritis. A possible T-lymphocyte disorder. (6977270)
1982
18
Lipoid nephrosis in the elderly. (7394611)
1980
19
Congenital lipoid nephrosis with left renal vein thrombosis and Chiari's syndrome. (468879)
1979
20
Lipoid nephrosis and focal glomerulosclerosis. (355987)
1978
21
Significance of complement (C3) in lipoid nephrosis and glomerulonephritis. (730303)
1978
22
Nephrotic syndrome with minimal glomerular lesions (lipoid nephrosis) in an adult diabetic patient. (576799)
1977
23
Postural proteinuria and lipoid nephrosis of 58 years' duration. (1009389)
1976
24
Minimal change and focal sclerotic lesions in lipoid nephrosis. (4368918)
1974
25
Proceedings: Significance of 'focal sclerosis' in lipoid nephrosis. (4853850)
1974
26
Pathogenesis of lipoid nephrosis: a disorder of T-cell function. (4140273)
1974
27
Natural history of childhood lipoid nephrosis. (4713549)
1973
28
Glomerular localisation of IgE in lipoid nephrosis. (4122790)
1973
29
Histometrical glomerular studies on the kidneys in multiple myeloma and in acute membranous glomerulonephritis (lipoid nephrosis). (5145535)
1971
30
Lipoid nephrosis. A multifold blind study, including quantitation. (5090999)
1971
31
Intraglomerular fibrin, platelet aggregation, and subendothelial deposits in lipoid nephrosis. (4189232)
1970
32
Lipoid nephrosis in 31 adult patients: renal biopsy study by light, electron, and fluorescence microscopy with experience in treatment. (5426747)
1970
33
Myxovirus-like particles in lipoid nephrosis. (5800520)
1969
34
Reversible gluco-amino-phosphaturia in a child with lipoid nephrosis. (13664174)
1959
35
A hitherto undescribed vulnerability of the juxtamedullary glomeruli in lipoid nephrosis. (13426687)
1957
36
Heparin in lipoid nephrosis; observations of the effects on edema, proteinuria, serum proteins, lipids and lipoproteins. (13196959)
1954
37
Plasma protein patterns in a case of lipoid nephrosis; an electrophoretic study. (13084095)
1953
38
Malarial therapy in lipoid nephrosis. (14918441)
1952
39
Methionine in lipoid nephrosis; a therapeutic trial. (12987080)
1952
40
Histochemical distribution of glycogen II. In the kidneys of patients with different pathological conditions, especially those with lipoid nephrosis. (14818524)
1951
41
Qualitative and quantitative changes in the plasma proteins of lipoid nephrosis demonstrated by electrophoresis. (14850819)
1951
42
Mucolytic enzyme systems. XI. Hyaluronidase inhibitor and serum mucoproteins in patients with lipoid nephrosis and acute glomerulonephritis. (14794778)
1950
43
Chronic Lipoid Nephrosis in Retrospect. (21407705)
1949
44
Lipoid nephrosis complicated by homologous serum jaundice. (18143938)
1949
45
The morphological backgrounds of genuine lipoid nephrosis. (18884732)
1948
46
Lipoid nephrosis; clinical and biochemical studies of 40 children, with 10 necropsies. (18866957)
1948
47
Treatment of lipoid nephrosis. (18895785)
1947
48
Lipoid nephrosis; a review of the disease with report of case. (21008695)
1946
49
A clinical and pathological study of subacute and chronic glomerulonephritis, including lipoid nephrosis. (19970414)
1938
50
Metabolism: The Status of Lipoid Nephrosis as a Clinical Entity. (18740759)
1928

Genetic Variations for Lipoid Nephrosis

Expression for genes affiliated with Lipoid Nephrosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipoid Nephrosis

Search GEO for disease gene expression data for Lipoid Nephrosis.

Pathways for genes affiliated with Lipoid Nephrosis

Sources:
52QIAGEN, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore
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Pathways related to Lipoid Nephrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4IL10, IL13
29.4IL13, IL10
39.4IL10, IL13
4
Hide members
9.1ALB, TF
59.1ALB, TF
68.9IL10, IL13, TF

Compounds for genes affiliated with Lipoid Nephrosis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB, 50PharmGKB
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Compounds related to Lipoid Nephrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1prednisolone45 29 1112.5IL13
2cyclosporin a45 29 6012.2TF
3gm-csf45 2911.2IL10
4aspartate4510.1ALB
5ovomucoid459.9TF, IL13
6penicillin459.9IL13, TF
7alpha-galactosylceramide459.8IL13, IL10
8mip 1alpha459.8IL13, IL10
9glatiramer acetate45 1110.8IL10, IL13
10praziquantel45 1110.8IL10, IL13
11as 10160 4510.8IL13, IL10
12il-12459.8IL13, IL10
13streptomycin45 1110.8TF, IL10
14cortisone45 2410.7IL10, IL13
15indoleamine459.7IL13, IL10
16montelukast45 50 29 1112.7IL10, IL13
17triamcinolone acetonide45 2910.7IL10, TF
18groalpha459.7IL10, IL13
19salbutamol45 50 29 11 2413.7IL13, IL10
208-isoprostane459.6IL10, TF
21kp-1019459.6ALB, TF
22Bismuth Subsalicylate119.6ALB, TF
23bismuth45 2410.6TF, ALB
24gelfoam459.6TF, ALB
25suprofen45 1110.5TF, ALB
26mycophenolic acid45 50 1111.5IL13, ALB
27il 10459.5IL13, IL10
28antipyrine45 1110.5ALB, TF
29dtpa459.5TF, ALB
30acetaldehyde45 29 2411.5TF, IL10
31tarc459.5IL10, IL13
32glutaraldehyde459.4ALB, TF
33ccl345 2910.4IL10, IL13
34clomipramine45 50 1111.4IL10, ALB
35enalapril45 50 1111.4IL10, ALB
36cyclophosphamide45 50 1111.3IL10, IL13, TF
37mycophenolate mofetil45 50 1111.3IL10, ALB
38ribavirin45 50 1111.2TF, IL10
39fluoxetine50 45 29 1112.2ALB, IL10
40diclofenac45 29 50 1112.2ALB, IL13
41pge2459.1IL10, IL13, TF
42alpha tocopherol459.1ALB, IL13, TF
43vitamin a45 11 2411.1ALB, IL13, TF
44calcitriol45 60 11 2412.0ALB, IL10, IL13
45methotrexate45 50 1110.9TF, IL10, ALB
46lactate458.9ALB, IL13, TF
47ivig458.7ALB, IL10
48thyroxine45 249.5ALB, IL10, IL13, TF
49tacrolimus45 50 1110.5TF, IL13, IL10, ALB
50histamine45 29 2410.5TF, IL13, IL10, ALB

GO Terms for genes affiliated with Lipoid Nephrosis

Sources:
16Gene Ontology
See all sources

Biological processes related to Lipoid Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:0025769.1ALB, TF

Products for genes affiliated with Lipoid Nephrosis

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Sources for Lipoid Nephrosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet