MCNS
MCID: LPD004
MIFTS: 42

Lipoid Nephrosis (MCNS) malady

Nephrological diseases category

Summaries for Lipoid Nephrosis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Minimal change disease is a kidney disorder that can lead to nephrotic syndrome, although the nephrons of the kidney look normal under a regular microscope. the most common symptom is swelling around the eyes, face, abdomen, and legs. other features include poor appetite, weight gain, and a foamy appearance of the urine. the cause of minimal change disease is unknown, but it may occur following an allergic reaction, immunization, or viral infection. treatment may involve the use of steroids such as prednisone. children often respond better to this therapy than adults. those who experience repeated relapses may benefit from the use of cytotoxic therapy, including cyclophosphamide, cyclosporine or chlorambucil. last updated: 8/4/2011

MalaCards: Lipoid Nephrosis, also known as minimal change disease, is related to glomerulonephritis and nephrotic syndrome. An important gene associated with Lipoid Nephrosis is IL13 (interleukin 13), and among its related pathways are Cytokine Network and Cytokines and Inflammatory Response. The compounds prednisolone and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include kidney, eye and monocytes.

Wikipedia:63 Minimal Change Disease (also known as Nil Lesions or Nil Disease (lipoid nephrosis)) is a disease of the... more...

Aliases & Classifications for Lipoid Nephrosis

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

lipoid nephrosis 8
minimal change disease 8 42
nephrotic syndrome with lesion of minimal change glomerulonephritis 8
nephrotic syndrome with lesion of minimal change nephrotic syndrome 8
idiopathic minimal change nephrotic syndrome 42
nephrotic syndrome, minimal change 60
glomerulonephritis, minimal change 60
nephrotic syndrome minimal change 44
minimal change glomerulonephritis 8
minimal change nephrotic syndrome 42
minimal change glomerulopathy 42
mcns 42


External Ids:

Disease Ontology8 DOID:10966
SNOMED-CT56 197592009, 44785005
MeSH34 D009402

Related Diseases for Lipoid Nephrosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lipoid Nephrosis:



Diseases related to lipoid nephrosis

Clinical Features for Lipoid Nephrosis

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Drugs & Therapeutics for Lipoid Nephrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lipoid Nephrosis

Drug clinical trials:

Search ClinicalTrials for Lipoid Nephrosis

Search NIH Clinical Center for Lipoid Nephrosis

Search CenterWatch for Lipoid Nephrosis

Genetic Tests for Lipoid Nephrosis

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Anatomical Context for Lipoid Nephrosis

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32MalaCards
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MalaCards organs/tissues related to Lipoid Nephrosis:

32
Kidney, Eye, Monocytes, T cells, Bone

Animal Models for Lipoid Nephrosis or affiliated genes

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Publications for Lipoid Nephrosis

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50PubMed
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Articles related to Lipoid Nephrosis:

(show top 50)    (show all 114)
idTitleAuthorsYear
1
T-cell lineage acute lymphoblastic leukemia with chromosome 5 abnormality in a patient with Crohn's disease and lipoid nephrosis. (10834511)
2000
2
Interleukin 10 inhibits vascular permeability factor release by peripheral blood mononuclear cells in patients with lipoid nephrosis. (9041534)
1997
3
Interleukin 10 and interleukin 13 synergize to inhibit vascular permeability factor release by peripheral blood mononuclear cells from patients with lipoid nephrosis. (9346389)
1997
4
Recombinant granulocyte-macrophage colony-stimulating factor modulates in vitro function of the peripheral blood mononuclear cells in lipoid nephrosis. (8342574)
1993
5
Ibuprofen-associated lipoid nephrosis without interstitial nephritis. (2741936)
1989
6
Decreased production of interleukin-1 by monocytes from patients with lipoid nephrosis. (2787718)
1989
7
Evaluation of T colony-stimulating factor in patients with lipoid nephrosis. (3484545)
1986
8
Impaired cellular immune responses in adult lipoid nephrosis patients. (4017301)
1985
9
Depression of local graft-versus-host reaction in patients with lipoid nephrosis. (3876448)
1985
10
Is house dust allergen a possible causal factor for relapses in lipoid nephrosis? (6711772)
1984
11
Defective cell-mediated immunity in lipoid nephrosis. (6230321)
1984
12
Adult onset lipoid nephrosis is not DR7 associated. (6415866)
1983
13
The treatment of minimal change nephrotic syndrome (lipoid nephrosis): cooperative studies of the Arbeitsgemeinschaft fA1r PAodiatrische Nephrologie (APN). (6752557)
1982
14
Renal vein thrombosis complicating lipoid nephrosis. (7113197)
1982
15
Deacetyl-thymosin alpha 1: synthesis and immunological effect on lipoid nephrosis lymphocytes. (7116512)
1982
16
Concanavalin A-induced suppressor cell activity in lipoid nephrosis. (6458879)
1981
17
Impaired cell-mediated immunity in lipoid nephrosis. (6977099)
1981
18
Lipoid nephrosis appearing as acute oliguric renal failure. (7362359)
1980
19
Hodgkin's disease and lipoid nephrosis. (67327)
1977
20
A study of the renal handling of water in lipoid nephrosis. (1250649)
1976
21
Letter: Lipoid nephrosis and focal glomerulosclerosis in a patient with polymyositis. (48714)
1975
22
Lipoid nephrosis and focal sclerosis distinct entities or spectrum of disease. (4853015)
1974
23
Glomerular localisation of IgE in lipoid nephrosis. (4122790)
1973
24
Lipoid nephrosis: an approach to the clinicopathologic analysis and dismemberment of idiopathic nephrotic syndrome with minimal glomerular changes. (4725964)
1973
25
Lipoid nephrosis in Hodgkin's disease. (4554878)
1972
26
Longitudinal studies of lipoid nephrosis. (4628295)
1972
27
Natural history of lipoid nephrosis and of membranous glomerulonephritis. (5710390)
1968
28
Cyclophosphamide in the treatment of idiopathic lipoid nephrosis. (6022179)
1967
29
An autopsy case of renal disease similar to lipoid nephrosis modified by steroid treatment. (4289007)
1966
30
Steroid nephropathy. A case of renal disease showing similar changes of lipoid nephrosis modified by steroid treatment. (4288721)
1966
31
The fine structure of the glomerulus in membranous glomerulonephritis (lipoid nephrosis) in adults. (13670133)
1959
32
Aminoaciduria in the course of lipoid nephrosis in children; the influence of ACTH. (13636858)
1959
33
Hormonal treatment of lipoid nephrosis]. (13537809)
1958
34
Bone diseases and lipoid nephrosis]. (13595983)
1958
35
Hormonal treatment of lipoid nephrosis; hospital statistics]. (13449505)
1957
36
Lipoid nephrosis; use of nitrogen mustards]. (13290846)
1955
37
Secondary eruptive xanthoma and naevus unius lateris with lipoid nephrosis. (13248245)
1955
38
The role of lipocaic hormone in pathogenesis of lipoid nephrosis syndrome]. (13266392)
1955
39
ACTH in lipoid nephrosis]. (13102710)
1953
40
Labeled methionine as an indicator of protein formation in children with lipoid nephrosis. (14797764)
1950
41
Mucolytic enzyme systems. XI. Hyaluronidase inhibitor and serum mucoproteins in patients with lipoid nephrosis and acute glomerulonephritis. (14794778)
1950
42
Lipoid nephrosis; a case of nephrosis in a white boy 26 years of age. (15401459)
1950
43
Chronic Lipoid Nephrosis in Retrospect. (21407705)
1949
44
The relationship between lipoid nephrosis and nephritis. (18141772)
1949
45
Lipoid nephrosis complicated by homologous serum jaundice. (18143938)
1949
46
The morphological backgrounds of genuine lipoid nephrosis. (18884732)
1948
47
Lipoid nephrosis with necropsy findings. (18860780)
1948
48
Treatment of lipoid nephrosis. (18895785)
1947
49
Lipoid nephrosis. (20272806)
1947
50
A CASE OF LIPOID NEPHROSIS. (20776077)
1931

Genetic Variations for Lipoid Nephrosis

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Expression for genes affiliated with Lipoid Nephrosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipoid Nephrosis

Search GEO for disease gene expression data for Lipoid Nephrosis.

Pathways for genes affiliated with Lipoid Nephrosis

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51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Lipoid Nephrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4IL10, IL13
29.4IL13, IL10
39.4IL10, IL13
4
Hide members
9.1ALB, TF
59.1ALB, TF
68.9IL10, IL13, TF

Compounds for genes affiliated with Lipoid Nephrosis

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Lipoid Nephrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1prednisolone44 28 1112.5IL13
2cyclosporin a44 28 5912.2TF
3gm-csf44 2811.2IL10
4aspartate4410.1ALB
5ovomucoid449.9TF, IL13
6penicillin449.9TF, IL13
7alpha-galactosylceramide449.8IL10, IL13
8mip 1alpha449.8IL13, IL10
9glatiramer acetate44 1110.8IL10, IL13
10praziquantel44 1110.8IL13, IL10
11as 10159 4410.8IL13, IL10
12streptomycin44 1110.8TF, IL10
13il-12449.8IL13, IL10
14cortisone44 2410.7IL10, IL13
15indoleamine449.7IL13, IL10
16montelukast44 49 28 1112.7IL13, IL10
17groalpha449.7IL13, IL10
18triamcinolone acetonide44 2810.7TF, IL10
19salbutamol44 49 28 11 2413.7IL10, IL13
208-isoprostane449.6IL10, TF
21Bismuth Subsalicylate119.6ALB, TF
22kp-1019449.6ALB, TF
23bismuth44 2410.6ALB, TF
24gelfoam449.6TF, ALB
25suprofen44 1110.5ALB, TF
26il 10449.5IL13, IL10
27mycophenolic acid44 49 1111.5ALB, IL13
28antipyrine44 1110.5ALB, TF
29dtpa449.5TF, ALB
30tarc449.5IL13, IL10
31acetaldehyde44 28 2411.4TF, IL10
32glutaraldehyde449.4ALB, TF
33ccl344 2810.4IL13, IL10
34clomipramine44 49 1111.4ALB, IL10
35enalapril44 49 1111.4IL10, ALB
36cyclophosphamide44 49 1111.3TF, IL13, IL10
37mycophenolate mofetil44 49 1111.3ALB, IL10
38ribavirin44 49 1111.2IL10, TF
39fluoxetine49 44 28 1112.2ALB, IL10
40diclofenac44 28 49 1112.2IL13, ALB
41pge2449.1IL13, TF, IL10
42alpha tocopherol449.1ALB, TF, IL13
43vitamin a44 11 2411.1ALB, IL13, TF
44calcitriol44 59 11 2412.0IL10, ALB, IL13
45methotrexate44 49 1110.9TF, IL10, ALB
46lactate448.9TF, IL13, ALB
47ivig448.7ALB, IL10
48thyroxine44 249.5IL10, TF, ALB, IL13
49tacrolimus44 49 1110.5ALB, IL10, IL13, TF
50histamine44 28 2410.5ALB, IL10, TF, IL13

GO Terms for genes affiliated with Lipoid Nephrosis

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16Gene Ontology
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Biological processes related to Lipoid Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:0025769.1ALB, TF

Products for genes affiliated with Lipoid Nephrosis

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Sources for Lipoid Nephrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet