MCNS
MCID: LPD004
MIFTS: 42

Lipoid Nephrosis (MCNS) malady

Nephrological diseases category

Summaries for Lipoid Nephrosis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Minimal change disease is a kidney disorder that can lead to nephrotic syndrome, although the nephrons of the kidney look normal under a regular microscope. the most common symptom is swelling around the eyes, face, abdomen, and legs. other features include poor appetite, weight gain, and a foamy appearance of the urine. the cause of minimal change disease is unknown, but it may occur following an allergic reaction, immunization, or viral infection. treatment may involve the use of steroids such as prednisone. children often respond better to this therapy than adults. those who experience repeated relapses may benefit from the use of cytotoxic therapy, including cyclophosphamide, cyclosporine or chlorambucil. last updated: 8/4/2011

MalaCards: Lipoid Nephrosis, also known as minimal change disease, is related to glomerulonephritis and nephrotic syndrome. An important gene associated with Lipoid Nephrosis is IL13 (interleukin 13), and among its related pathways are Cytokine Network and Cytokines and Inflammatory Response. The compounds prednisolone and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include kidney, eye and monocytes.

Wikipedia:63 Minimal Change Disease (also known as Nil Lesions or Nil Disease (lipoid nephrosis)) is a disease of the... more...

Aliases & Classifications for Lipoid Nephrosis

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

lipoid nephrosis 8
minimal change disease 8 42
nephrotic syndrome with lesion of minimal change glomerulonephritis 8
nephrotic syndrome with lesion of minimal change nephrotic syndrome 8
idiopathic minimal change nephrotic syndrome 42
nephrotic syndrome, minimal change 60
glomerulonephritis, minimal change 60
nephrotic syndrome minimal change 44
minimal change glomerulonephritis 8
minimal change nephrotic syndrome 42
minimal change glomerulopathy 42
mcns 42


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Disease Ontology8 DOID:10966
SNOMED-CT56 197592009, 44785005
MeSH34 D009402

Related Diseases for Lipoid Nephrosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lipoid Nephrosis:



Diseases related to lipoid nephrosis

Clinical Features for Lipoid Nephrosis

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Drugs & Therapeutics for Lipoid Nephrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Lipoid Nephrosis

Search CenterWatch for Lipoid Nephrosis

Genetic Tests for Lipoid Nephrosis

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Anatomical Context for Lipoid Nephrosis

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32MalaCards
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MalaCards organs/tissues related to Lipoid Nephrosis:

32
Kidney, Eye, Monocytes, T cells, Bone

Animal Models for Lipoid Nephrosis or affiliated genes

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Publications for Lipoid Nephrosis

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50PubMed
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Articles related to Lipoid Nephrosis:

(show top 50)    (show all 114)
idTitleAuthorsYear
1
T-cell lineage acute lymphoblastic leukemia with chromosome 5 abnormality in a patient with Crohn's disease and lipoid nephrosis. (10834511)
2000
2
Interleukin 12 upregulates the release of vascular permeability factor by peripheral blood mononuclear cells from patients with lipoid nephrosis. (9578066)
1998
3
Renin activity and aldosterone level in the plasma of children with lipoid nephrosis]. (2251209)
1990
4
Effect of methylprednisolone pulse therapy on cellular immunity abnormalities in a patient with lipoid nephrosis. (2077423)
1990
5
A transient monocyte defective function in idiopathic nephrotic syndrome (lipoid nephrosis). (3170113)
1988
6
Evaluation of T colony-stimulating factor in patients with lipoid nephrosis. (3484545)
1986
7
An overlapping syndrome of IgA nephropathy and lipoid nephrosis. (3538845)
1986
8
Impaired cellular immune responses in adult lipoid nephrosis patients. (4017301)
1985
9
Alterations of T cell subpopulations in childhood lipoid nephrosis and its relation to immunosuppressive treatment. (6335580)
1984
10
Is house dust allergen a possible causal factor for relapses in lipoid nephrosis? (6711772)
1984
11
Is lipoid nephrosis an "allergic" disease? (6217600)
1982
12
The treatment of minimal change nephrotic syndrome (lipoid nephrosis): cooperative studies of the Arbeitsgemeinschaft fA1r PAodiatrische Nephrologie (APN). (6752557)
1982
13
Fenoprofen nephropathy: lipoid nephrosis and interstitial nephritis. A possible T-lymphocyte disorder. (6977270)
1982
14
Concanavalin A-induced suppressor cell activity in lipoid nephrosis. (6458879)
1981
15
Significance of complement (C3) in lipoid nephrosis and glomerulonephritis. (730303)
1978
16
Nephrotic syndrome with minimal glomerular lesions (lipoid nephrosis) in an adult diabetic patient. (576799)
1977
17
Hodgkin's disease and lipoid nephrosis. (67327)
1977
18
Letter: Lipoid nephrosis and focal glomerulosclerosis in a patient with polymyositis. (48714)
1975
19
Proceedings: Significance of 'focal sclerosis' in lipoid nephrosis. (4853850)
1974
20
Glomerular localisation of IgE in lipoid nephrosis. (4122790)
1973
21
Lipoid nephrosis in Hodgkin's disease. (4554878)
1972
22
Histometrical glomerular studies on the kidneys in multiple myeloma and in acute membranous glomerulonephritis (lipoid nephrosis). (5145535)
1971
23
Lipoid nephrosis. A multifold blind study, including quantitation. (5090999)
1971
24
Myxovirus-like particles in lipoid nephrosis. (5800520)
1969
25
Natural history of lipoid nephrosis and of membranous glomerulonephritis. (5710390)
1968
26
Cyclophosphamide in the treatment of idiopathic lipoid nephrosis. (6022179)
1967
27
Steroid nephropathy. A case of renal disease showing similar changes of lipoid nephrosis modified by steroid treatment. (4288721)
1966
28
The fine structure of the glomerulus in membranous glomerulonephritis (lipoid nephrosis) in adults. (13670133)
1959
29
Aminoaciduria in the course of lipoid nephrosis in children; the influence of ACTH. (13636858)
1959
30
Reversible gluco-amino-phosphaturia in a child with lipoid nephrosis. (13664174)
1959
31
Hormonal treatment of lipoid nephrosis]. (13537809)
1958
32
Bone diseases and lipoid nephrosis]. (13595983)
1958
33
Lipoid nephrosis; use of nitrogen mustards]. (13290846)
1955
34
Secondary eruptive xanthoma and naevus unius lateris with lipoid nephrosis. (13248245)
1955
35
The role of lipocaic hormone in pathogenesis of lipoid nephrosis syndrome]. (13266392)
1955
36
Heparin in lipoid nephrosis; observations of the effects on edema, proteinuria, serum proteins, lipids and lipoproteins. (13196959)
1954
37
ACTH in lipoid nephrosis]. (13102710)
1953
38
Malarial therapy in lipoid nephrosis. (14918441)
1952
39
Methionine in lipoid nephrosis; a therapeutic trial. (12987080)
1952
40
Histochemical distribution of glycogen II. In the kidneys of patients with different pathological conditions, especially those with lipoid nephrosis. (14818524)
1951
41
Mucolytic enzyme systems. XI. Hyaluronidase inhibitor and serum mucoproteins in patients with lipoid nephrosis and acute glomerulonephritis. (14794778)
1950
42
Lipoid nephrosis; a case of nephrosis in a white boy 26 years of age. (15401459)
1950
43
Chronic Lipoid Nephrosis in Retrospect. (21407705)
1949
44
The relationship between lipoid nephrosis and nephritis. (18141772)
1949
45
Lipoid nephrosis complicated by homologous serum jaundice. (18143938)
1949
46
The morphological backgrounds of genuine lipoid nephrosis. (18884732)
1948
47
Treatment of lipoid nephrosis. (18895785)
1947
48
A clinical and pathological study of subacute and chronic glomerulonephritis, including lipoid nephrosis. (19970414)
1938
49
A CASE OF LIPOID NEPHROSIS. (20776077)
1931
50
Metabolism: The Status of Lipoid Nephrosis as a Clinical Entity. (18740759)
1928

Genetic Variations for Lipoid Nephrosis

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Expression for genes affiliated with Lipoid Nephrosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipoid Nephrosis

Search GEO for disease gene expression data for Lipoid Nephrosis.

Pathways for genes affiliated with Lipoid Nephrosis

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51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Lipoid Nephrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4IL10, IL13
29.4IL13, IL10
39.4IL10, IL13
4
Hide members
9.1ALB, TF
59.1ALB, TF
68.9IL10, IL13, TF

Compounds for genes affiliated with Lipoid Nephrosis

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Lipoid Nephrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1prednisolone44 28 1112.5IL13
2cyclosporin a44 28 5912.2TF
3gm-csf44 2811.2IL10
4aspartate4410.1ALB
5pentoxifylline44 1111.0IL13
6ovomucoid449.9TF, IL13
7penicillin449.9IL13, TF
8alpha-galactosylceramide449.8IL13, IL10
9mip 1alpha449.8IL13, IL10
10glatiramer acetate44 1110.8IL10, IL13
11praziquantel44 1110.8IL10, IL13
12as 10159 4410.8IL13, IL10
13il-12449.8IL13, IL10
14streptomycin44 1110.8TF, IL10
15cortisone44 2410.7IL10, IL13
16indoleamine449.7IL13, IL10
17montelukast44 49 28 1112.7IL10, IL13
18triamcinolone acetonide44 2810.7IL10, TF
19groalpha449.7IL10, IL13
20salbutamol44 49 28 11 2413.7IL13, IL10
218-isoprostane449.6IL10, TF
22kp-1019449.6ALB, TF
23Bismuth Subsalicylate119.6ALB, TF
24bismuth44 2410.6TF, ALB
25gelfoam449.6TF, ALB
26suprofen44 1110.5TF, ALB
27il 10449.5IL10, IL13
28mycophenolic acid44 49 1111.5IL13, ALB
29antipyrine44 1110.5ALB, TF
30dtpa449.5TF, ALB
31tarc449.5IL10, IL13
32acetaldehyde44 28 2411.4IL10, TF
33glutaraldehyde449.4ALB, TF
34clomipramine44 49 1111.4IL10, ALB
35enalapril44 49 1111.4IL10, ALB
36cyclophosphamide44 49 1111.3IL10, IL13, TF
37mycophenolate mofetil44 49 1111.3ALB, IL10
38ribavirin44 49 1111.2IL10, TF
39fluoxetine49 44 28 1112.2IL10, ALB
40diclofenac44 28 49 1112.2IL13, ALB
41pge2449.1TF, IL13, IL10
42alpha tocopherol449.1ALB, IL13, TF
43vitamin a44 11 2411.1ALB, IL13, TF
44calcitriol44 59 11 2412.0ALB, IL10, IL13
45methotrexate44 49 1110.9TF, IL10, ALB
46lactate448.9ALB, IL13, TF
47ivig448.7ALB, IL10
48thyroxine44 249.5ALB, IL10, IL13, TF
49tacrolimus44 49 1110.5TF, IL13, IL10, ALB
50histamine44 28 2410.5TF, IL13, IL10, ALB

GO Terms for genes affiliated with Lipoid Nephrosis

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16Gene Ontology
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Biological processes related to Lipoid Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:0025769.1ALB, TF

Products for genes affiliated with Lipoid Nephrosis

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Sources for Lipoid Nephrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet