MCID: LPD004
MIFTS: 46

Lipoid Nephrosis

Categories: Rare diseases, Nephrological diseases

Aliases & Classifications for Lipoid Nephrosis

MalaCards integrated aliases for Lipoid Nephrosis:

Name: Lipoid Nephrosis 12 14 69
Minimal Change Disease 12 49
Nephrotic Syndrome with Lesion of Minimal Change Glomerulonephritis 12
Nephrotic Syndrome with Lesion of Minimal Change Nephrotic Syndrome 12
Idiopathic Minimal Change Nephrotic Syndrome 49
Glomerulonephritis, Minimal Change 69
Nephrotic Syndrome, Minimal Change 69
Minimal Change Glomerulonephritis 12
Minimal Change Nephrotic Syndrome 49
Nephrotic Syndrome Minimal Change 51
Minimal Change Glomerulopathy 49
Nephrosis, Lipoid 41
Mcns 49

Classifications:



External Ids:

Disease Ontology 12 DOID:10966
ICD10 32 N04
MeSH 41 D009402
NCIt 46 C34844
SNOMED-CT 64 197592009 44785005

Summaries for Lipoid Nephrosis

NIH Rare Diseases : 49 Minimal change disease is a kidney disease in which there is damage to the filtering units of the kidney (glomeruli). It is the most common cause of nephrotic syndrome in children. Nephrotic syndrome is comprised of a group of symptoms including protein in the urine (proteinuria), low protein levels in the blood, high cholesterol and triglycerides, an increased risk for blood clots, and swelling. Other features of this disease include weight gain and a foamy appearance of the urine. The cause of minimal change disease is unknown, but it may occur following an allergic reaction or infection. Treatment may involve the use of steroids. Last updated: 1/12/2018

MalaCards based summary : Lipoid Nephrosis, also known as minimal change disease, is related to mesangial proliferative glomerulonephritis and focal segmental glomerulosclerosis. An important gene associated with Lipoid Nephrosis is IL13 (Interleukin 13), and among its related pathways/superpathways are NF-kappaB Signaling and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Tacrolimus and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and t cells, and related phenotype is renal/urinary system.

Wikipedia : 72 Minimal change disease (also known as MCD and nil disease, among others) is a disease affecting the... more...

Related Diseases for Lipoid Nephrosis

Diseases related to Lipoid Nephrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 mesangial proliferative glomerulonephritis 32.1 CCL2 CD79A
2 focal segmental glomerulosclerosis 31.1 ALB CD2AP NPHS1 NPHS2 SYNPO
3 focal segmental glomerulosclerosis 1 30.5 CD2AP NPHS1 NPHS2
4 diffuse glomerulonephritis 30.4 ALB CD79A
5 glomerulonephritis 29.9 ALB CCL2 CD79A NPHS1 NPHS2
6 membranous nephropathy 29.7 ALB CD2AP CD79A NPHS1 NPHS2
7 nephrotic syndrome 29.6 ALB CD2AP NPHS1 NPHS2 SYNPO
8 idiopathic steroid-sensitive nephrotic syndrome with minimal change 10.9
9 c1q nephropathy 10.8
10 ascaridiasis 10.5 IL10 IL13
11 trichuriasis 10.5 IL10 IL13
12 apple allergy 10.5 IL10 IL13
13 familial idiopathic steroid-resistant nephrotic syndrome with minimal changes 10.5 NPHS1 NPHS2
14 beta-lactam allergy 10.5 IL10 IL13
15 immunoglobulin a deficiency 1 10.5 CD79A IL10
16 sporotrichosis 10.5 CD79A IL10
17 cow milk allergy 10.5 CD79A IL10
18 hypoparathyroidism, sensorineural deafness, and renal disease 10.4 NPHS1 NPHS2
19 strongyloidiasis 10.4 CD79A IL13
20 clonorchiasis 10.4 CD79A IL10
21 orofacial granulomatosis 10.4 CD79A IL10
22 peanut allergy 10.4 IL10 IL13
23 sporadic idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis 10.4 CD2AP NPHS2
24 taeniasis 10.4 CD79A IL10
25 cork-handlers' disease 10.4 ALB CD79A
26 ostertagiasis 10.4 ALB CD79A
27 dermatitis, atopic, 3 10.4 ALB CD79A
28 orthostatic proteinuria 10.4 ALB CD79A
29 root caries 10.4 ALB CD79A
30 fascioliasis 10.4 ALB IL10
31 coccidiosis 10.4 CD79A IL10
32 night blindness, congenital stationary, type 1a 10.4 ALB IL13
33 parotitis 10.4 ALB CD79A
34 focal dermal hypoplasia 10.4 ALB CD79A
35 non-secretory myeloma 10.3 ALB CD79A
36 pollen allergy 10.3 CD79A IL13
37 hemorrhagic fever 10.3 ALB IL10
38 hypersensitivity reaction type iii disease 10.3 ALB CD79A
39 protein-losing enteropathy 10.3 ALB CD79A
40 paranasal sinus disease 10.3 CD79A IL10 IL13
41 nasal cavity disease 10.3 CD79A IL10 IL13
42 nose disease 10.3 CD79A IL10 IL13
43 parasitic helminthiasis infectious disease 10.3 CD79A IL10 IL13
44 upper respiratory tract disease 10.3 CD79A IL10 IL13
45 tick-borne encephalitis 10.3 ALB IL10
46 acute proliferative glomerulonephritis 10.3 CCL2 CD79A
47 ulcerative stomatitis 10.3 ALB CD79A
48 nonspecific interstitial pneumonia 10.3 CCL2 IL13
49 food allergy 10.3 ALB IL10 IL13
50 pneumocystosis 10.3 ALB CD79A

Graphical network of the top 20 diseases related to Lipoid Nephrosis:



Diseases related to Lipoid Nephrosis

Symptoms & Phenotypes for Lipoid Nephrosis

MGI Mouse Phenotypes related to Lipoid Nephrosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.17 ALB CD2AP CD79A NAGLU NPHS1 NPHS2

Drugs & Therapeutics for Lipoid Nephrosis

Drugs for Lipoid Nephrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3 104987-11-3 445643 439492
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
4
Prednisone Approved, Vet_approved Phase 4,Phase 3 53-03-2 5865
5
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
6
Alfacalcidol Approved, Nutraceutical Phase 4 41294-56-8 5282181
7 Prednisolone acetate Phase 4,Phase 3
8 beta-endorphin Phase 4
9 glucocorticoids Phase 4,Phase 3
10 Methylprednisolone acetate Phase 4,Phase 3
11 Methylprednisolone Hemisuccinate Phase 4,Phase 3
12 Adrenocorticotropic Hormone Phase 4
13 Gastrointestinal Agents Phase 4,Phase 3
14 Neuroprotective Agents Phase 4
15 Hormone Antagonists Phase 4,Phase 3
16 Hormones Phase 4,Phase 3
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
18 Peripheral Nervous System Agents Phase 4,Phase 3
19 Antiemetics Phase 4,Phase 3
20 Immunoglobulin A Phase 4
21 Prednisolone hemisuccinate Phase 4,Phase 3
22 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
23 Prednisolone phosphate Phase 4,Phase 3
24 Anti-Inflammatory Agents Phase 4,Phase 3
25 Protective Agents Phase 4
26 Antineoplastic Agents, Hormonal Phase 4,Phase 3
27 Melanocyte-Stimulating Hormones Phase 4
28 Autonomic Agents Phase 4,Phase 3
29 Calcineurin Inhibitors Phase 4,Phase 2,Phase 3
30 Micronutrients Phase 4
31 Trace Elements Phase 4
32 Vitamins Phase 4
33 Hydroxycholecalciferols Phase 4
34 Bone Density Conservation Agents Phase 4
35
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
36
Mycophenolic acid Approved Phase 3 24280-93-1 446541
37
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
38
rituximab Approved Phase 3,Phase 2 174722-31-7 10201696
39
Valproic Acid Approved, Investigational Phase 2, Phase 3 99-66-1 3121
40 Dexamethasone acetate Phase 3 1177-87-3
41
protease inhibitors Phase 3
42 HIV Protease Inhibitors Phase 3
43 Antibodies, Monoclonal Phase 3
44 Anti-Bacterial Agents Phase 3
45 Anti-Infective Agents Phase 3
46 Immunoglobulins Phase 3
47 Antibiotics, Antitubercular Phase 3
48 Antibodies Phase 3
49 BB 1101 Phase 3
50 Antirheumatic Agents Phase 3,Phase 2

Interventional clinical trials:

(show all 25)

# Name Status NCT ID Phase Drugs
1 Treatment of Resistant Nephrotic Syndrome With ACTH Gel (ACTHAR) Completed NCT01129284 Phase 4 ACTHAR gel
2 Tacrolimus Versus Prednisolone for the Treatment of Minimal Change Disease Recruiting NCT00982072 Phase 4 tacrolimus;prednisolone
3 Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy Not yet recruiting NCT03210688 Phase 4 Prednisolone;Alfacalcidol
4 Rituximab in Multirelapsing Minimal Change Disease (MCD) or Focal Segmental Glomerulosclerosis (FSGS) Completed NCT00981838 Phase 3 Rituximab
5 Therapeutic Effect of Tacrolimus in Combination With Low Dose Corticosteroid in Adult Patient With Minimal Change Nephritic Syndrome Completed NCT01084980 Phase 2, Phase 3 Tacrolimus
6 Steroid Treatment for Kidney Disease Completed NCT00065611 Phase 3 Oral dexamethasone
7 Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Dependent Nephrotic Syndrome Completed NCT02438982 Phase 3 Tacrolimus;Rituximab
8 Efficacy of Rituximab For the Treatment of Calcineurin Inhibitors Dependent Nephrotic Syndrome During Childhood Completed NCT01268033 Phase 2, Phase 3 Rituximab;Placebo
9 Evaluation of Low Dose Corticosteroids Efficiency, Associated With Myfortic ® in the Treatment of Nephrotic Syndrome Completed NCT01197040 Phase 3 Prednisone;acid mycophenolic (Myfortic)
10 Valproic Acid for Idiopathic Nephrotic Syndrome Recruiting NCT02896270 Phase 2, Phase 3 Valproic Acid
11 Efficacy of Rituximab in Comparison to Continued Corticosteroid Treatment in Idiopathic Nephrotic Syndrome Not yet recruiting NCT03298698 Phase 3 Rituximab;Prednisone
12 Podocyte Retinoids Completed NCT00098020 Phase 2 Isotretinoin
13 Pilot Study to Evaluate the Safety and Efficacy of Abatacept in Adults and Children 6 Years and Older With Excessive Loss of Protein in the Urine Due to Either Focal Segmental Glomerulosclerosis (FSGS) or Minimal Change Disease (MCD) Recruiting NCT02592798 Phase 2 Abatacept
14 A Phase 1 Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ManNAc in Subjects With Primary Podocyte Diseases Recruiting NCT02639260 Phase 1 N-acetyl-mannosamine (ManNAc)
15 The Effectiveness of Enough Steroids as Inducement Therapy in Minimal Change Disease-like IgA Nephropathy Completed NCT01451710 Prednisone or Prednisolone
16 MRCP: A Reliable, Non Invasive Method for Staging Chronic Pancreatitis in Pediatrics Completed NCT02869893 Secretin
17 Kidney Disease Biomarkers Completed NCT00255398
18 Lupus Nephritis Biomarker Study: Baseline Characteristics of Patients Completed NCT01470183
19 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129
20 Nephrotic Syndrome Study Network Recruiting NCT01209000
21 Diagnostic Value of Linked Color Imaging for Minimal Change Esophagitis in Nonerosive Reflux Esophagitis and GERD Recruiting NCT03068572
22 Study of The Association of Mutations in The NPHS2 Gene and Nephrotic Syndrome in Children and Adults in Middle East Recruiting NCT03326037
23 INSIGHT (Insight Into Nephrotic Syndrome) Recruiting NCT01605266
24 Genetic Causes of FSGS, Nephrotic Syndrome, or Kidney Failure Recruiting NCT02194582
25 Vitamin D Supplementation in Glomerular Disease Suspended NCT01835639

Search NIH Clinical Center for Lipoid Nephrosis

Cochrane evidence based reviews: nephrosis, lipoid

Genetic Tests for Lipoid Nephrosis

Anatomical Context for Lipoid Nephrosis

MalaCards organs/tissues related to Lipoid Nephrosis:

38
Kidney, Bone, T Cells, Monocytes

Publications for Lipoid Nephrosis

Articles related to Lipoid Nephrosis:

(show top 50) (show all 115)
# Title Authors Year
1
50 Years Ago in TheJournal ofPediatrics: Effect of Cyclophosphamide on Lipoid Nephrosis in the Human and on Aminonucleoside Nephrosis in the Rat. ( 27017462 )
2016
2
Cytokine mRNA profile in lipoid nephrosis: evidence for increased IL-8 mRNA stability. ( 12138264 )
2002
3
T-cell lineage acute lymphoblastic leukemia with chromosome 5 abnormality in a patient with Crohn's disease and lipoid nephrosis. ( 10834511 )
2000
4
Interleukin 12 upregulates the release of vascular permeability factor by peripheral blood mononuclear cells from patients with lipoid nephrosis. ( 9578066 )
1998
5
Anti-interleukin 8 antibody abolishes effects of lipoid nephrosis cytokine. ( 9686956 )
1998
6
Changing perspective of lipoid nephrosis in Iranian children. ( 9874333 )
1998
7
Interleukin 10 inhibits vascular permeability factor release by peripheral blood mononuclear cells in patients with lipoid nephrosis. ( 9041534 )
1997
8
Interleukin 10 and interleukin 13 synergize to inhibit vascular permeability factor release by peripheral blood mononuclear cells from patients with lipoid nephrosis. ( 9346389 )
1997
9
Decreased release of IL-10 by monocytes from patients with lipoid nephrosis. ( 8536379 )
1995
10
Effect of lipoid nephrosis cytokine on glomerular sulfated compounds and albuminuria. ( 8580016 )
1995
11
Inner ear damage due to lipoid nephrosis. ( 8357609 )
1993
12
Proteinuria selectivity index--prognostic value in lipoid nephrosis and related diseases. ( 8247178 )
1993
13
Recombinant granulocyte-macrophage colony-stimulating factor modulates in vitro function of the peripheral blood mononuclear cells in lipoid nephrosis. ( 8342574 )
1993
14
Acquired factor VIII autoantibody (AAb) in the course of lipoid nephrosis. ( 8302482 )
1993
15
[Renin activity and aldosterone level in the plasma of children with lipoid nephrosis]. ( 2251209 )
1990
16
Effect of methylprednisolone pulse therapy on cellular immunity abnormalities in a patient with lipoid nephrosis. ( 2077423 )
1990
17
Ibuprofen-associated lipoid nephrosis without interstitial nephritis. ( 2741936 )
1989
18
Decreased production of interleukin-1 by monocytes from patients with lipoid nephrosis. ( 2787718 )
1989
19
Interferon and lipoid nephrosis. ( 2458041 )
1988
20
A transient monocyte defective function in idiopathic nephrotic syndrome (lipoid nephrosis). ( 3170113 )
1988
21
Evaluation of T colony-stimulating factor in patients with lipoid nephrosis. ( 3484545 )
1986
22
An overlapping syndrome of IgA nephropathy and lipoid nephrosis. ( 3538845 )
1986
23
Impaired cellular immune responses in adult lipoid nephrosis patients. ( 4017301 )
1985
24
Impaired T-lymphocyte colony formation in lipoid nephrosis. ( 3878248 )
1985
25
Depression of local graft-versus-host reaction in patients with lipoid nephrosis. ( 3876448 )
1985
26
Impaired delayed hypersensitivity in lipoid nephrosis. ( 6462316 )
1984
27
Defective cell-mediated immunity in lipoid nephrosis. ( 6230321 )
1984
28
Is house dust allergen a possible causal factor for relapses in lipoid nephrosis? ( 6711772 )
1984
29
Alterations of T cell subpopulations in childhood lipoid nephrosis and its relation to immunosuppressive treatment. ( 6335580 )
1984
30
HLA-DR 7 in adult lipoid nephrosis patients. Significant difference according to the age of onset. ( 6603586 )
1983
31
Allergy and lipoid nephrosis. ( 6404133 )
1983
32
Adult onset lipoid nephrosis is not DR7 associated. ( 6415866 )
1983
33
Effect of thymic humoral factor on a local graft-versus-host reaction of lymphocytes in patients with lipoid nephrosis. ( 6984140 )
1982
34
Deacetyl-thymosin alpha 1: synthesis and immunological effect on lipoid nephrosis lymphocytes. ( 7116512 )
1982
35
Renal vein thrombosis complicating lipoid nephrosis. ( 7113197 )
1982
36
Fenoprofen nephropathy: lipoid nephrosis and interstitial nephritis. A possible T-lymphocyte disorder. ( 6977270 )
1982
37
Impaired local graft-versus-host reaction in lipoid nephrosis. ( 6981777 )
1982
38
The treatment of minimal change nephrotic syndrome (lipoid nephrosis): cooperative studies of the Arbeitsgemeinschaft fA1r PAodiatrische Nephrologie (APN). ( 6752557 )
1982
39
Is lipoid nephrosis an "allergic" disease? ( 6217600 )
1982
40
In vitro lymphocyte dysfunction in lipoid nephrosis mediated by suppressor cells. ( 6218418 )
1982
41
Impaired cell-mediated immunity in lipoid nephrosis. ( 6977099 )
1981
42
Concanavalin A-induced suppressor cell activity in lipoid nephrosis. ( 6458879 )
1981
43
Lipoid nephrosis in the elderly. ( 7394611 )
1980
44
Lipoid nephrosis appearing as acute oliguric renal failure. ( 7362359 )
1980
45
Congenital lipoid nephrosis with left renal vein thrombosis and Chiari's syndrome. ( 468879 )
1979
46
Lipoid nephrosis and focal glomerulosclerosis. ( 355987 )
1978
47
Significance of complement (C3) in lipoid nephrosis and glomerulonephritis. ( 730303 )
1978
48
Nephrotic syndrome with minimal glomerular lesions (lipoid nephrosis) in an adult diabetic patient. ( 576799 )
1977
49
Hodgkin's disease and lipoid nephrosis. ( 67327 )
1977
50
Postural proteinuria and lipoid nephrosis of 58 years' duration. ( 1009389 )
1976

Variations for Lipoid Nephrosis

Expression for Lipoid Nephrosis

Search GEO for disease gene expression data for Lipoid Nephrosis.

Pathways for Lipoid Nephrosis

GO Terms for Lipoid Nephrosis

Cellular components related to Lipoid Nephrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ALB CCL2 IL10 IL13 SERPINB7 TF
2 slit diaphragm GO:0036057 8.62 NPHS1 NPHS2

Biological processes related to Lipoid Nephrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell proliferation GO:0042100 9.16 CD79A IL10
2 negative regulation of endothelial cell apoptotic process GO:2000352 8.96 IL10 IL13
3 positive regulation of macrophage activation GO:0043032 8.62 IL10 IL13

Molecular functions related to Lipoid Nephrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CCL2 IL10 IL13

Sources for Lipoid Nephrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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