MCID: LPM004
MIFTS: 60

Lipoma malady

Skin diseases, Cancer diseases, Genetic diseases categories

Summaries for Lipoma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A lipoma is a benign tumor composed of adipose tissue (body fat). It is the most common benign form of... more...

MalaCards: Lipoma, also known as familial multiple lipomatosis, is related to liposarcoma and myxoid liposarcoma. An important gene associated with Lipoma is LPP (LIM domain containing preferred translocation partner in lipoma), and among its related pathways are Inhibition of Ribosome Biogenesis by p14(ARF) and Prostate Cancer. The compounds roscovitine and benzo(a)pyrene have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and spinal cord.

Disease Ontology:8 A cell type benign neoplasm that is composed of lipocytes.

Description from OMIM:46 151900

Aliases & Classifications for Lipoma

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8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 48Orphanet, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases
Anatomical: Skin diseases


Aliases & Descriptions:

lipoma 8 46 10 44 60
familial multiple lipomatosis 48 46
benign lipomatous tumor 8 60
lipomatous neoplasm 8 60
lipomatosis, familial multiple 8
benign symmetrical lipomatosis 60
benign tumor of adipose tissue 8
lipomatous neoplasm nos 8
tumor of adipose tissue 8
multiple lipomatosis 8
lipomatous tumor 8


External Ids:

Disease Ontology8 DOID:3315
NCIt39 C3192
MeSH34 D008067
ICD9CM27 214, 214.9
OMIM46 151900
ICD10 via Orphanet26 E88.2

Related Diseases for Lipoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 382)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma30.7C11orf95, MDM2, RB1, DES, CDK4, CD34
2myxoid liposarcoma30.2CDK4, MDM2
3adenoma30.1HMGA2, PLAG1, CDK4, RB1, S100A1
4angiosarcoma29.9CD34
5pleomorphic adenoma29.9HMGA2, PLAG1
6leiomyoma29.9S100A1, DES, CD34, HMGA2
7adenocarcinoma29.9MDM2, RB1, CDK4, CD34, PLAG1, HMGA2
8dermatofibrosarcoma29.8MDM2
9squamous cell carcinoma29.8S100A1, MDM2, RB1, CDK4, CD34, HMGA2
10retinoblastoma29.8MDM2, RB1, CDK4
11lung cancer29.8HMGA2, CDK4, RB1, MDM2, S100A1
12chondroma29.6LHFP, LPP, HMGA2
13desmoid tumor29.6DES
14angiomyolipoma29.6DES, S100A1
15fibrosarcoma29.6MDM2, DES, CD34
16dermatofibrosarcoma protuberans29.6CD34, DES, S100A1
17hemangiopericytoma29.6S100A1, MDM2, DES, CD34
18chondrosarcoma29.6S100A1, MDM2, DES, CDK4, HMGA2
19granular cell tumor29.6S100A1, DES, CD68
20leiomyosarcoma29.6S100A1, MDM2, RB1, DES, CDK4, CD34
21sarcoma29.6S100A1, MDM2, RB1, DES, CDK4, CD99
22pituitary adenoma29.6RB1, CDK4, HMGA2
23spindle cell lipoma10.8
24pleomorphic lipoma10.7
25endobronchial lipoma10.6
26chondroid lipoma10.6
27infiltrating lipoma10.5
28lipoma of colon10.5
29breast lipoma10.5
30spinal cord lipoma10.4
31intussusception10.4
32lumbosacral lipoma10.4
33corpus callosum lipoma10.4
34pleural lipoma10.4
35lipomatosis10.4
36chest wall lipoma10.3
37esophageal lipoma10.3
38skin lipoma10.3
39atypical lipomatous tumor10.3
40esophagitis10.3
41duodenitis10.2
42angiolipoma10.2
43intestinal obstruction10.2
44axonal neuropathy10.2
45bullous pemphigoid10.2
46alcohol abuse10.2
47atopic dermatitis10.2
48pellagra10.2
49dermatitis10.2
50tongue disease10.2

Graphical network of the top 20 diseases related to Lipoma:



Diseases related to lipoma

Clinical Features for Lipoma

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Sources:
46OMIM
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Clinical features from OMIM:

151900

Clinical synopsis from OMIM:

151900

Drugs & Therapeutics for Lipoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Lipoma

Search NIH Clinical Center for Lipoma

Search CenterWatch for Lipoma

Genetic Tests for Lipoma

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Anatomical Context for Lipoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Lipoma:

32
Colon, Breast, Spinal cord, Tongue, Skin, Bone, Pancreas, Liver, Lung, Adipocyte, Heart, Adrenal gland, Brain, Small intestine, Pituitary, Salivary gland, Prostate, Smooth muscle, B cells, Testes, Cerebellum, Uterus, Kidney, Ovary, Appendix

Animal Models for Lipoma or affiliated genes

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Publications for Lipoma

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Sources:
50PubMed
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Articles related to Lipoma:

(show top 50)    (show all 1001)
idTitleAuthorsYear
1
A large parosteal ossifying lipoma of lower limb encircling the femur. (24433545)
2014
2
Response to Letter to the Editor: Cerebellopontine Angle Lipoma with Mild Brainstem Compression in a 13-year-old female. (24270718)
2014
3
Cerebellopontine Angle Lipoma with Mild Brainstem Compression in a 13-year-old patient. (24270716)
2014
4
Lipoma Arborescens Successfully Treated With 90Y Synovectomy. (24321826)
2014
5
Ischemic stroke and incidental finding of a right atrial lipoma. (24149062)
2013
6
A massive posterior neck mass: lipoma or something more sinister? (24223314)
2013
7
Radiological predictors of neurological compromise in adults with filum terminale lipoma. (23545622)
2013
8
Bladder lipoma. (23871930)
2013
9
Laparoscopy-assisted resection of ileocecal intussusception caused by ileal pedunculated lipoma. (24229019)
2013
10
Rectal lipoma associated with genital prolapse. (24349839)
2013
11
Successful removal of endobronchial lipoma by flexible bronchoscopy using electrosurgical snare. (23482342)
2013
12
Ultrasound challenge: secondary breast angiosarcoma mimicking lipoma. (23701498)
2013
13
Noninvasive lipoma size reduction using high-intensity focused ultrasound. (23866057)
2013
14
Nasopalpebral lipoma-coloboma syndrome: clinical, radiological, and histopathological description of a novel sporadic case. (23636874)
2013
15
Intradural lipoma: timely intervention is what matters. (23505088)
2013
16
Multiple giant nerve abscesses presenting like lipoma in a treated patient of Hansen's disease. (22715828)
2012
17
Intravestibular space occupying lesions of lipoma and schwannoma. (22119483)
2012
18
Echo rounds: visceral pericardial lipoma involving the great cardiac vein with large pericardial effusion. (22886844)
2012
19
Adult ileoileal intussusception induced by an ileal lipoma diagnosed preoperatively: report of a case and review of the literature. (22167483)
2012
20
Intermuscular lipoma of the gluteus muscles compressing the sciatic nerve: an inverted sciatic hernia. (22900844)
2012
21
Pedunculated cecal lipoma causing colo-colonic intussusception: a rare case report. (23259130)
2012
22
High cervical nondysraphic intradural extramedullary lipoma. (22824709)
2012
23
Pleural lipoma: a non-surgical lesion? (22371386)
2012
24
Lipoma mimicking a perforation. (22998835)
2012
25
Laparoscopic resection of small bowel lipoma causing obscure gastrointestinal bleeding. (21691916)
2012
26
Lipoma of the pancreas, a case report and a review of the literature. (22229078)
2011
27
Pretrichial incision for forehead lipoma excision. (20696628)
2011
28
Let-7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data. (21412931)
2011
29
Bilateral knee lipoma arborescens combined with osteoarthritis in elderly patients. (21986162)
2011
30
A giant adrenal lipoma presenting in a woman with chronic mild postprandial abdominal pain: a case report. (21466677)
2011
31
MR imaging of fat-containing tumours: the distinction between lipoma and liposarcoma. (20593147)
2010
32
Ulnar nerve entrapment in Guyon's canal due to a lipoma. (21423081)
2010
33
Extraluminal lipoma with common femoral vein obstruction: a cause of chronic venous insufficiency. (19216966)
2009
34
A case of orbital lipoma with exophthalmos and visual disturbance. (19763768)
2009
35
Spindle cell lipoma of the oral cavity. (16456321)
2006
36
Orbital pleomorphic lipoma in a 25-year-old male. (16704722)
2006
37
Cerebellopontine angle lipoma presenting with hemifacial spasm: case report and review of the literature. (16048703)
2005
38
Isolated spinal cord lipoma. (14592621)
2003
39
Pathogenesis of lumbosacral lipoma: a test of the "premature dysjunction" theory. (11359100)
2001
40
Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. (11474286)
2001
41
Pleomorphic lipoma of the parotid gland. (9578889)
1998
42
Spindle cell lipoma in a 14-month-old girl. (8583335)
1995
43
Spindle cell lipoma--a pseudoangiomatous variant. (8063285)
1994
44
Endobronchial lipoma simulating bronchogenic carcinoma. (7971640)
1994
45
Effect of insulin and carbenoxolone on adrenaline stimulated lipolysis in human lipoma. (2079320)
1990
46
Spindle-cell lipoma: an unusual oral presentation. (2512544)
1989
47
Pleomorphic lipoma: a benign tumor simulating liposarcoma. A clinicopathologic analysis of 48 cases. (7459800)
1981
48
Intrathoracic lipomas. Report of three cases and review of the literature with emphasis on endobronchial lipoma. (423588)
1979
49
Endobronchial lipoma. A review of the literature and report of an unusual case. (5369291)
1969
50
Benign Tumours, Fibroma, Myoma and Lipoma encapsuled in the Wall of the Stomach. (19974057)
1909

Genetic Variations for Lipoma

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Expression for genes affiliated with Lipoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipoma

Search GEO for disease gene expression data for Lipoma.

Pathways for genes affiliated with Lipoma

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 55SinoBiological, 29KEGG
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Pathways related to Lipoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4RB1, MDM2
2
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10.3MDM2, RB1, CDK4
3
Transcription P53 signaling pathway
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10.3MDM2, RB1, CDK4
410.3MDM2, RB1, CDK4
5
Hide members
10.3MDM2, RB1, CDK4
6
Hide members
10.3CDK4, RB1, MDM2
7
Hide members
10.3CDK4, RB1, MDM2

Compounds for genes affiliated with Lipoma

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44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Lipoma according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1roscovitine4410.7CDK4, MDM2, RB1
2benzo(a)pyrene4410.7RB1, MDM2, CDK4
3adpribose4410.7DES, CDK4, MDM2, RB1
4flavopiridol44 1111.7MDM2, CDK4, RB1
5carboplatin44 49 1112.6MDM2, RB1, CDK4
6purvalanol a44 59 1112.6RB1, CDK4
7hematoxylin4410.6S100A1, DES, CD34
8doxorubicin44 49 1112.6DES, RB1, MDM2, HMGA2, CDK4
9toluidine4410.6DES, S100A1
10agar4410.6CD34, CDK4, RB1, MDM2
11silver4410.6S100A1, DES, CD34
12thymidine44 2411.6CD34, MDM2, CDK4, DES, RB1
1312-o-tetradecanoylphorbol 13-acetate4410.6CDK4, CD34, DES, RB1
14progesterone44 59 28 11 2414.6S100A1, MDM2, RB1, DES, CDK4, CD34
15biotin44 11 2412.5DES, RB1, S100A1
16vegf4410.5DES, CDK4, CD99, RB1, CD34, MDM2
17reticulin4410.5DES, CD34
18thymidylate4410.5CDK4, RB1, MDM2
19p0024410.5MDM2, RB1, DES
20retinoic acid44 2411.4DES, S100A1, RB1, HMGA2, CD34, CDK4
21paraffin4410.4RB1, S100A1, MDM2, HMGA2, CD34, CD99
22mucicarmine4410.4DES, S100A1
23glycogen44 2411.4MDM2, S100A1, DES, CDK4
24adriamycin4410.3MDM2, RB1, DES
25actinomycin d4410.2HMGA2, DES, RB1, MDM2
26gossypol4410.1RB1, CDK4

GO Terms for genes affiliated with Lipoma

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16Gene Ontology
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Biological processes related to Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of gene expressionGO:01062810.3HMGA2, PLAG1, CD34, MDM2

Products for genes affiliated with Lipoma

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Sources for Lipoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet