MCID: LPM004
MIFTS: 64

Lipoma malady

Genetic diseases, Skin diseases, Rare diseases, Cancer diseases categories

Summaries for Lipoma

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OMIM:47 Familial multiple lipomatosis is a rare autosomal dominant disorder characterized by numerous encapsulated lipomas on... (151900) more...

MalaCards based summary: Lipoma, also known as benign tumor of adipose tissue, is related to liposarcoma and lipomatosis, and has symptoms including autosomal dominant inheritance, multiple lipomas and abnormality of metabolism/homeostasis. An important gene associated with Lipoma is LPP (LIM domain containing preferred translocation partner in lipoma), and among its related pathways are DNA damage ATM ATR regulation of G1 S checkpoint and RB in Cancer. The compounds leptomycin b and roscovitine have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and spinal cord, and related mouse phenotypes are behavior/neurological and reproductive system.

Disease Ontology:10 A cell type benign neoplasm that is composed of lipocytes.

Wikipedia:65 A lipoma is a benign tumor composed of adipose tissue (body fat). It is the most common benign form of... more...

Aliases & Classifications for Lipoma

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Sources:
47OMIM, 10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 49Orphanet, 29ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 28ICD10 via Orphanet
See all sources

Lipoma, Aliases & Descriptions:

Name: Lipoma 47 10 12 45 62
Benign Tumor of Adipose Tissue 10 62
Lipomatosis, Familial Multiple 10 62
Benign Lipomatous Tumor 10 62
Tumor of Adipose Tissue 10 62
Lipomatous Neoplasm 10 62
 
Benign Symmetrical Lipomatosis 62
Familial Multiple Lipomatosis 49
Lipomatosis, Multiple 62
Multiple Lipomatosis 10
Lipomatous Tumor 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Skin diseases
Orphanet: 49 
Rare skin diseases


External Ids:

OMIM47 151900
Disease Ontology10 DOID:3315
ICD9CM29 214.9, 214
NCIt40 C3192
MeSH35 D008067
Orphanet49 199276
ICD10 via Orphanet28 E88.2

Related Diseases for Lipoma

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Diseases related to Lipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 416)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma30.8CDK4, MDM2, HMGA2, DES
2lipomatosis30.6HMGA2, MEN1
3myxoid liposarcoma30.2CDK4, MDM2
4adenoma30.1CDK4, HMGA2, MEN1
5dermatofibrosarcoma protuberans30.1MDM2
6leiomyoma30.1DES, HMGA2
7adenocarcinoma30.0MEN1, HMGA2, MDM2, CDK4
8dedifferentiated liposarcoma30.0DES, HMGA2, MDM2, CDK4
9ependymoma29.9MEN1, MDM2
10pleomorphic adenoma29.9MDM2, HMGA2, DES
11retinoblastoma29.9MEN1, MDM2, CDK4
12hemangiopericytoma29.7MDM2, DES
13chondroma29.7HMGA2, LPP, LHFP
14b-cell lymphomas29.7CDK4, MDM2, HMGA2
15leiomyosarcoma29.7CDK4, MDM2, DES
16pituitary adenoma29.6CDK4, HMGA2, MEN1
17chondrosarcoma29.6CDK4, MDM2, HMGA2, DES
18sarcoma29.6CDK4, MDM2, HMGA2, DES
19spindle cell lipoma10.9
20endobronchial lipoma10.7
21pleomorphic lipoma10.7
22chondroid lipoma10.6
23intussusception10.5
24infiltrating lipoma10.5
25lumbosacral lipoma10.5
26pleural lipoma10.5
27spinal cord lipoma10.4
28esophageal lipoma10.4
29atypical lipomatous tumor10.3
30nasopalpebral lipoma coloboma syndrome10.3
31corpus callosum lipoma10.3
32esophagitis10.3
33breast lipoma10.3
34skin lipoma10.3
35intestinal obstruction10.3
36mediastinitis10.3
37duodenitis10.3
38angiolipoma10.3
39familial angiolipomatosis10.2
40bannayan-riley-ruvalcaba syndrome10.2
41chest wall lipoma10.2
42cervicitis10.2
43neuropathy10.2
44lipoma of the rectum10.2
45axillary lipoma10.2
46adiposis dolorosa10.2
47proteus syndrome, somatic10.2
48tendon sheath lipoma10.2
49fibroma10.2
50internal auditory canal lipoma10.2

Graphical network of the top 20 diseases related to Lipoma:



Diseases related to lipoma

Symptoms for Lipoma

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Symptoms by clinical synopsis from OMIM:

151900

Clinical features from OMIM:

151900

HPO human phenotypes related to Lipoma:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 multiple lipomas HP:0001012
3 abnormality of metabolism/homeostasis HP:0001939

Drugs & Therapeutics for Lipoma

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Drug clinical trials:

Search ClinicalTrials for Lipoma

Search NIH Clinical Center for Lipoma

Genetic Tests for Lipoma

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Anatomical Context for Lipoma

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MalaCards organs/tissues related to Lipoma:

33
Colon, Breast, Spinal cord, Tongue, Skin, Bone, Lung, Pancreas, Liver, Adipocyte, Brain, Heart, Adrenal gland, Small intestine, Pituitary, Eye, Cerebellum, Smooth muscle, Skeletal muscle, Kidney, Salivary gland, Ovary, Uterus, Prostate, Testes, B cells, Appendix

Animal Models for Lipoma or affiliated genes

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MGI Mouse Phenotypes related to Lipoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.9DES, LHFPL5, HMGA2, MDM2, CDK4
2MP:00053897.7CDK4, MDM2, HMGA2, MEN1, LPP
3MP:00053697.7DES, MEN1, MDM2, CDK4
4MP:00036317.7CDK4, MDM2, HMGA2, MEN1, LHFPL5

Publications for Lipoma

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Articles related to Lipoma:

(show top 50)    (show all 1076)
idTitleAuthorsYear
1
En-bloc resection of a giant retroperitoneal lipoma: a case report and review of the literature. (25890295)
2015
2
Extensive lipoma-like changes of myxoid liposarcoma: morphologic, immunohistochemical, and molecular cytogenetic analyses. (25650275)
2015
3
Rare occurrence of lip spindle cell lipoma. (25815220)
2015
4
"Low-Fat" Pseudoangiomatous Spindle Cell Lipoma: A Rare Variant With Loss of 13q14 Region. (25839893)
2015
5
Heel lipoma mimicking plantar fasciitis in a ballroom dancer. (25624040)
2015
6
Torsion of a giant mesocolic lipoma in a child with Bannayan-Riley-Ruvalcaba syndrome. (25008800)
2014
7
Ischemic stroke and incidental finding of a right atrial lipoma. (24149062)
2013
8
Cyclin-dependent kinase inhibitor 2A (p16) distinguishes well-differentiated liposarcoma from lipoma. (23600700)
2013
9
Gastric lipoma and pyloric obstruction in a 51-year-old woman. (23648507)
2013
10
Torsion of an abdominal-wall pedunculated lipoma: a rare differential diagnosis for right iliac fossa pain. (23781377)
2013
11
Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma:report of a case. (24166610)
2013
12
Laparoscopic enucleation of a giant submucosal esophageal lipoma. Case report and literature review. (23826462)
2013
13
Parosteal lipoma Report of 15 new cases and a review of the literature. (23698599)
2013
14
Transoral robotic surgery for huge spindle cell lipoma of the hypopharynx. (23851787)
2013
15
A massive posterior neck mass: lipoma or something more sinister? (24223314)
2013
16
Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases. (23672313)
2013
17
Lipoma or liposarcoma? A cautionary case report. (21865105)
2012
18
Intracranial lipoma with subgaleal extension: An interesting case report with review of literature. (22954994)
2012
19
Pleomorphic lipoma lacking mature fat component in extensive myxoid stroma: a great diagnostic challenge. (23148444)
2012
20
Multiple giant nerve abscesses presenting like lipoma in a treated patient of Hansen's disease. (22715828)
2012
21
A giant cardiac lipoma associated with ventricular inversion and ventricular aneurysm: ultrasonography and CT imaging findings. (22215833)
2012
22
Intra-osseous lipoma of the talus: a case report. (22535830)
2012
23
The first case of renal lipoma in a child. (21683239)
2011
24
Solitary plexiform neurofibroma, a pitfall in diagnosis of lipoma. (22778282)
2010
25
Spindle cell lipoma of the orbit: a case report of an unusual orbital pathology. (20827617)
2010
26
Surgical Removal of lipoma from an area with tattooed skin. (21103075)
2010
27
Spinal cord lipoma without dysraphism in the infancy that extends intracranially. Case report and review of the literature. (18291460)
2009
28
Cellular and molecular features of lipoma tissue: comparison with normal adipose tissue. (19558598)
2009
29
Mutations in the lipoma HMGIC fusion partner-like 5 (LHFPL5) gene cause autosomal recessive nonsyndromic hearing loss. (16752389)
2006
30
Prognostic factors affecting urologic outcome after untethering surgery for lumbosacral lipoma. (16586137)
2006
31
Spindle cell lipoma of the floor of the mouth. A case report. (16878055)
2006
32
Pathology quiz case 2. Spindle cell lipoma. (16490884)
2006
33
Intramedullary migration of spinal cord lipoma. (14617729)
2003
34
Lipoma arborescens (diffuse articular lipomatosis). (14577726)
2003
35
Non-dysraphic intramedullary spinal cord lipoma. A case report. (12477239)
2002
36
Neurologic variant of epidermal nevus syndrome with a facial lipoma. (11422522)
2001
37
The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma. (10755400)
2000
38
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
39
Spindle-cell lipoma of the preseptal eyelid. (9612807)
1998
40
Endobronchial lipoma: a report of three cases. (8551668)
1996
41
Chondroid lipoma: an ultrastructural and immunohistochemical analysis with further observations regarding its differentiation. (7628841)
1995
42
Infiltrating lipoma of the chest wall. (8255655)
1993
43
Neurocytoma/lipoma (neurolipocytoma) of the cerebellum. (8474606)
1993
44
Spinal neurenteric cyst. Association with vertebral anomalies, diastematomyelia, dorsal fistula, and lipoma. (6701769)
1984
45
Spindle cell lipoma. (6487132)
1984
46
Cervical spinal cord lipoma with extension into the posterior fossa. (6856073)
1983
47
Endobronchial lipoma. A case report. (483103)
1979
48
Endobronchial lipoma associated with squamous metaplasia of bronchial mucosa. (1124014)
1975
49
Lipoma of the rectum. (14006359)
1962
50
Agenesis of the corpus callosum; lipoma of the corpus callosum; their roentgen recognition and differentiation. (14854179)
1951

Variations for Lipoma

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Expression for genes affiliated with Lipoma

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Search GEO for disease gene expression data for Lipoma.

Pathways for genes affiliated with Lipoma

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Compounds for genes affiliated with Lipoma

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Compounds related to Lipoma according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1leptomycin b45 6110.9LPP, MDM2
2roscovitine459.6MDM2, CDK4
3benzo(a)pyrene459.6CDK4, MDM2
4fludarabine45 51 1311.6CDK4, MDM2
5flavopiridol45 1310.6CDK4, MDM2
6trastuzumab45 51 1311.6CDK4, MDM2
7gefitinib45 51 1311.5CDK4, MDM2
8progestin459.4CDK4, DES
9nad+459.4MDM2, DES
10actinomycin d459.3DES, HMGA2, MDM2
11carboplatin45 51 1311.2MDM2, CDK4
12adpribose459.2DES, MDM2, CDK4
13glycogen45 2610.1CDK4, MDM2, DES
14estradiol45 26 1311.1CDK4, MDM2, DES
15proline459.1CDK4, MDM2, DES
16iron45 2610.1CDK4, MDM2, DES
17cisplatin45 51 61 1312.1CDK4, MDM2, HMGA2
18geldanamycin45 51 61 1312.0CDK4, MDM2
19cyclic amp45 2610.0DES, MDM2, CDK4
20progesterone45 30 61 26 1312.8DES, MDM2, CDK4
21doxorubicin45 51 1310.7CDK4, MDM2, HMGA2, DES
22paraffin458.7CDK4, MDM2, HMGA2, DES
23thymidine45 269.3CDK4, MDM2, MEN1, DES
24vegf458.3DES, MEN1, MDM2, CDK4
25estrogen458.3DES, MEN1, MDM2, CDK4
26serine458.1DES, MEN1, MDM2, CDK4

GO Terms for genes affiliated with Lipoma

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Cellular components related to Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:00007859.0CDK4, MEN1
2nucleoplasmGO:00056547.8CDK4, MDM2, HMGA2, MEN1

Biological processes related to Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:00711579.3CDK4, MDM2
2negative regulation of transcription from RNA polymerase II promoterGO:00001228.7MDM2, HMGA2, MEN1
3positive regulation of apoptotic processGO:00430658.5CDK4, HMGA2, MEN1
4negative regulation of transcription, DNA-templatedGO:00458928.4MEN1, HMGA2, MDM2

Molecular functions related to Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055157.2CDK4, MDM2, HMGA2, MEN1, LPP, DES

Products for genes affiliated with Lipoma

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Sources for Lipoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet