MCID: LPM004
MIFTS: 65

Lipoma malady

Genetic diseases, Skin diseases, Rare diseases, Cancer diseases categories
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Summaries for Lipoma

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Wikipedia:65 A lipoma is a benign tumor composed of adipose tissue (body fat). It is the most common benign form of... more...

MalaCards based summary: Lipoma, also known as benign tumor of adipose tissue, is related to lipomatosis and dermatofibrosarcoma protuberans, and has symptoms including An important gene associated with Lipoma is LPP (LIM domain containing preferred translocation partner in lipoma), and among its related pathways are DNA damage ATM ATR regulation of G1 S checkpoint and RB in Cancer. The compounds leptomycin b and roscovitine have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and spinal cord, and related mouse phenotypes are behavior/neurological and reproductive system.

Disease Ontology:8 A cell type benign neoplasm that is composed of lipocytes.

Description from OMIM:46 151900

Aliases & Classifications for Lipoma

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 26ICD10 via Orphanet
See all sources

Lipoma, Aliases & Descriptions:

Name: Lipoma 8 46 10 44 62
Benign Tumor of Adipose Tissue 8 62
Lipomatosis, Familial Multiple 8 62
Familial Multiple Lipomatosis 48 46
Benign Lipomatous Tumor 8 62
Tumor of Adipose Tissue 8 62
 
Lipomatous Neoplasm 8 62
Benign Symmetrical Lipomatosis 62
Lipomatosis, Multiple 62
Multiple Lipomatosis 8
Lipomatous Tumor 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Skin diseases
Orphanet: 48 
Rare skin diseases


External Ids:

Disease Ontology8 DOID:3315
NCIt39 C3192
MeSH34 D008067
ICD9CM27 214.9, 214
OMIM46 151900
ICD10 via Orphanet26 E88.2

Related Diseases for Lipoma

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Diseases related to Lipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 414)
idRelated DiseaseScoreTop Affiliating Genes
1lipomatosis30.7HMGA2, MEN1
2dermatofibrosarcoma protuberans30.7MDM2
3liposarcoma30.5CDK4, MDM2, HMGA2, DES
4myxoid liposarcoma30.4CDK4, MDM2
5leiomyoma30.2DES, HMGA2
6ependymoma30.0MEN1, MDM2
7hemangiopericytoma30.0MDM2, DES
8pleomorphic adenoma29.9MDM2, HMGA2, DES
9chondroma29.9HMGA2, LPP, LHFP
10adenoma29.7CDK4, HMGA2, MEN1
11dedifferentiated liposarcoma29.6DES, HMGA2, MDM2, CDK4
12b-cell lymphomas29.6CDK4, MDM2, HMGA2
13leiomyosarcoma29.6CDK4, MDM2, DES
14retinoblastoma29.5MEN1, MDM2, CDK4
15adenocarcinoma29.5MEN1, HMGA2, MDM2, CDK4
16pituitary adenoma29.4CDK4, HMGA2, MEN1
17chondrosarcoma29.3CDK4, MDM2, HMGA2, DES
18sarcoma29.3CDK4, MDM2, HMGA2, DES
19spindle cell lipoma10.9
20endobronchial lipoma10.7
21pleomorphic lipoma10.7
22chondroid lipoma10.6
23infiltrating lipoma10.5
24intussusception10.5
25lumbosacral lipoma10.5
26pleural lipoma10.4
27spinal cord lipoma10.4
28esophageal lipoma10.4
29corpus callosum lipoma10.3
30esophagitis10.3
31nasopalpebral lipoma coloboma syndrome10.3
32breast lipoma10.3
33skin lipoma10.3
34atypical lipomatous tumor10.3
35mediastinitis10.3
36duodenitis10.3
37angiolipoma10.3
38familial angiolipomatosis10.2
39chest wall lipoma10.2
40cervicitis10.2
41intestinal obstruction10.2
42neuropathy10.2
43smooth muscle tumor10.2HMGA2, DES
44uterine sarcoma10.2MDM2, DES
45external auditory meatus lipoma10.2
46tendon sheath lipoma10.2
47internal auditory canal lipoma10.2
48lipoma of the rectum10.2
49fibroma10.2
50axillary lipoma10.2

Graphical network of the top 20 diseases related to Lipoma:



Diseases related to lipoma

Symptoms for Lipoma

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Symptoms by clinical synopsis from OMIM:

151900

Clinical features from OMIM:

151900

HPO human phenotypes related to Lipoma:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 multiple lipomas HP:0001012
3 abnormality of metabolism/homeostasis HP:0001939

Drugs & Therapeutics for Lipoma

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Drug clinical trials:

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Search NIH Clinical Center for Lipoma

Genetic Tests for Lipoma

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Anatomical Context for Lipoma

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MalaCards organs/tissues related to Lipoma:

32
Colon, Breast, Spinal cord, Tongue, Skin, Bone, Lung, Pancreas, Liver, Adipocyte, Heart, Adrenal gland, Brain, Small intestine, Pituitary, Eye, Cerebellum, Smooth muscle, Kidney, Salivary gland, Ovary, Uterus, Prostate, Testes, B cells, Appendix

Animal Models for Lipoma or affiliated genes

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MGI Mouse Phenotypes related to Lipoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.9DES, LHFPL5, HMGA2, MDM2, CDK4
2MP:00053897.7CDK4, MDM2, HMGA2, MEN1, LPP
3MP:00053697.7DES, MEN1, MDM2, CDK4
4MP:00036317.7CDK4, MDM2, HMGA2, MEN1, LHFPL5

Publications for Lipoma

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Articles related to Lipoma:

(show top 50)    (show all 1037)
idTitleAuthorsYear
1
Torsion of a giant mesocolic lipoma in a child with Bannayan-Riley-Ruvalcaba syndrome. (25008800)
2014
2
A giant subpectoral lipoma. (25396199)
2014
3
Ischemic stroke and incidental finding of a right atrial lipoma. (24149062)
2013
4
Cyclin-dependent kinase inhibitor 2A (p16) distinguishes well-differentiated liposarcoma from lipoma. (23600700)
2013
5
Gastric lipoma and pyloric obstruction in a 51-year-old woman. (23648507)
2013
6
Torsion of an abdominal-wall pedunculated lipoma: a rare differential diagnosis for right iliac fossa pain. (23781377)
2013
7
Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma:report of a case. (24166610)
2013
8
Laparoscopic enucleation of a giant submucosal esophageal lipoma. Case report and literature review. (23826462)
2013
9
Parosteal lipoma Report of 15 new cases and a review of the literature. (23698599)
2013
10
Transoral robotic surgery for huge spindle cell lipoma of the hypopharynx. (23851787)
2013
11
A massive posterior neck mass: lipoma or something more sinister? (24223314)
2013
12
Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases. (23672313)
2013
13
Lipoma or liposarcoma? A cautionary case report. (21865105)
2012
14
Intracranial lipoma with subgaleal extension: An interesting case report with review of literature. (22954994)
2012
15
Pleomorphic lipoma lacking mature fat component in extensive myxoid stroma: a great diagnostic challenge. (23148444)
2012
16
Multiple giant nerve abscesses presenting like lipoma in a treated patient of Hansen's disease. (22715828)
2012
17
A giant cardiac lipoma associated with ventricular inversion and ventricular aneurysm: ultrasonography and CT imaging findings. (22215833)
2012
18
Intra-osseous lipoma of the talus: a case report. (22535830)
2012
19
Parosteal ossifying lipoma of the fibula: a case report with contrast-enhanced MR study and a review of the literature. (22941147)
2012
20
Diagnostics of peripherally located intrathoracic lipoma. (23322965)
2012
21
The first case of renal lipoma in a child. (21683239)
2011
22
Solitary plexiform neurofibroma, a pitfall in diagnosis of lipoma. (22778282)
2010
23
Spindle cell lipoma of the orbit: a case report of an unusual orbital pathology. (20827617)
2010
24
Surgical Removal of lipoma from an area with tattooed skin. (21103075)
2010
25
Spinal cord lipoma without dysraphism in the infancy that extends intracranially. Case report and review of the literature. (18291460)
2009
26
Cellular and molecular features of lipoma tissue: comparison with normal adipose tissue. (19558598)
2009
27
Mutations in the lipoma HMGIC fusion partner-like 5 (LHFPL5) gene cause autosomal recessive nonsyndromic hearing loss. (16752389)
2006
28
Prognostic factors affecting urologic outcome after untethering surgery for lumbosacral lipoma. (16586137)
2006
29
Spindle cell lipoma of the floor of the mouth. A case report. (16878055)
2006
30
Pathology quiz case 2. Spindle cell lipoma. (16490884)
2006
31
Intramedullary migration of spinal cord lipoma. (14617729)
2003
32
Lipoma arborescens (diffuse articular lipomatosis). (14577726)
2003
33
Non-dysraphic intramedullary spinal cord lipoma. A case report. (12477239)
2002
34
Neurologic variant of epidermal nevus syndrome with a facial lipoma. (11422522)
2001
35
Sciatic neuropathy secondary to infiltrating intermuscular lipoma of the thigh. (11562557)
2001
36
Spindle cell lipoma of the hypopharynx. (11453572)
2001
37
The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma. (10755400)
2000
38
Expression of growth hormone receptor in human liposarcomas and lipomas. (10854539)
2000
39
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
40
Spindle-cell lipoma of the preseptal eyelid. (9612807)
1998
41
Endobronchial lipoma: a report of three cases. (8551668)
1996
42
Chondroid lipoma: an ultrastructural and immunohistochemical analysis with further observations regarding its differentiation. (7628841)
1995
43
Infiltrating lipoma of the chest wall. (8255655)
1993
44
Neurocytoma/lipoma (neurolipocytoma) of the cerebellum. (8474606)
1993
45
Spinal neurenteric cyst. Association with vertebral anomalies, diastematomyelia, dorsal fistula, and lipoma. (6701769)
1984
46
Spindle cell lipoma. (6487132)
1984
47
Cervical spinal cord lipoma with extension into the posterior fossa. (6856073)
1983
48
Endobronchial lipoma. A case report. (483103)
1979
49
Endobronchial lipoma associated with squamous metaplasia of bronchial mucosa. (1124014)
1975
50
Agenesis of the corpus callosum; lipoma of the corpus callosum; their roentgen recognition and differentiation. (14854179)
1951

Variations for Lipoma

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Expression for genes affiliated with Lipoma

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Expression patterns in normal tissues for genes affiliated with Lipoma

Search GEO for disease gene expression data for Lipoma.

Pathways for genes affiliated with Lipoma

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Compounds for genes affiliated with Lipoma

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Compounds related to Lipoma according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1leptomycin b44 6110.9LPP, MDM2
2roscovitine449.6MDM2, CDK4
3benzo(a)pyrene449.6CDK4, MDM2
4fludarabine44 50 1111.6CDK4, MDM2
5flavopiridol44 1110.6CDK4, MDM2
6trastuzumab44 50 1111.6CDK4, MDM2
7gefitinib44 50 1111.5CDK4, MDM2
8progestin449.4CDK4, DES
9nad+449.4MDM2, DES
10actinomycin d449.3DES, HMGA2, MDM2
11carboplatin44 50 1111.2MDM2, CDK4
12adpribose449.2DES, MDM2, CDK4
13glycogen44 2410.1CDK4, MDM2, DES
14estradiol44 24 1111.1CDK4, MDM2, DES
15proline449.1CDK4, MDM2, DES
16iron44 2410.1CDK4, MDM2, DES
17cisplatin44 50 61 1112.1CDK4, MDM2, HMGA2
18geldanamycin44 50 61 1112.0CDK4, MDM2
19cyclic amp44 2410.0DES, MDM2, CDK4
20progesterone44 28 61 24 1112.8DES, MDM2, CDK4
21doxorubicin44 50 1110.7CDK4, MDM2, HMGA2, DES
22paraffin448.7CDK4, MDM2, HMGA2, DES
23thymidine44 249.3CDK4, MDM2, MEN1, DES
24vegf448.3DES, MEN1, MDM2, CDK4
25estrogen448.3DES, MEN1, MDM2, CDK4
26serine448.1DES, MEN1, MDM2, CDK4

GO Terms for genes affiliated with Lipoma

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Cellular components related to Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:0007859.0CDK4, MEN1
2nucleoplasmGO:0056547.8CDK4, MDM2, HMGA2, MEN1

Biological processes related to Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:0711579.3CDK4, MDM2
2negative regulation of transcription from RNA polymerase II promoterGO:0001228.7MDM2, HMGA2, MEN1
3positive regulation of apoptotic processGO:0430658.5CDK4, HMGA2, MEN1
4negative regulation of transcription, DNA-templatedGO:0458928.4MEN1, HMGA2, MDM2

Molecular functions related to Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.2CDK4, MDM2, HMGA2, MEN1, LPP, DES

Products for genes affiliated with Lipoma

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Sources for Lipoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet