Lipoma malady

Wikipedia: A lipoma is a benign tumor composed of adipose tissue. It is the most common form of soft tissue tumor....⁴⁴ more...

MalaCards: Lipoma, also known as benign lipomatous tumor, is related to spindle cell lipoma and chondroid lipoma. An important gene associated with Lipoma is LHFPL3 (lipoma HMGIC fusion partner-like 3), and among its related pathways are Cytoskeletal Signaling and Glioblastoma Multiforme. The drugs prednisone and prednisolone tebutate and the compounds progestin and reticulin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, colon and adipocyte, and related mouse phenotypes are cellular and homeostasis/metabolism.

Disease Ontology: A cell type benign neoplasm that is composed of lipocytes.⁶

Aliases & Descriptions:

lipoma 6 7 8 33 32 43 benign lipomatous tumor 6 43 lipomatous neoplasm nos (morphologic abnormality) 6 lipomatous neoplasm (morphologic abnormality) 6 tumor of adipose tissue (disorder) 6 benign lipomatous tumor (disorder) 6 lipomatosis, familial multiple 6 benign tumor of adipose tissue 6

benign symmetrical lipomatosis 43 lipomatous tumor (disorder) 6 multiple lipomatosis 6 lipomatous neoplasm 43 lipomatous tumor 6 benign neoplasm 43 neoplasms 43

Diseases related to lipoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1173)

id	Related Disease	Score	Top Affiliating Genes
1	spindle cell lipoma	33.0	VIM, UBE2D1, S100A1, CD99, CD34, CDK4
2	chondroid lipoma	32.5	CD68, MKL2, C11orf95
3	skin lipoma	32.2	ARHGEF1, APPL1
4	lipomatosis	31.0	UCP1, MEN1, HMGA1, HMGA2, PTEN, ACTC1
5	myoma	31.0	DES, PGR
6	lipoma of colon	30.8	MSRB3, NFIB, TGM1, PROM2, SLC17A5
7	nasopharynx carcinoma	30.6	CD99, CDKN2A, CDK4, MMP3, MDM2, AMACR
8	atypical lipomatous tumor	30.5	CDKN2A, CDK4, MDM2, HMGA1, HMGA2, PLAG1
9	tongue cancer	30.5	VIM, CDKN2A, F3, PTEN
10	soft tissue neoplasm	30.3	CDK4, MDM2
11	lumbosacral lipoma	30.1	SPTLC1, CRLF1
12	breast cancer	29.2	UBE2D1, MMP3, MDM2, TNF, PTEN, PGR
13	liposarcoma	29.2	LRP1, VIM, FUS, CDKN2A, CD34, CDK4
14	sex cord-gonadal stromal tumor	29.1	VIM, DES, PGR
15	bannayan-riley-ruvalcaba syndrome	28.5	VIM, LPP, LHFP, CD34, FLCN, INS
16	spindle cell liposarcoma	28.1	CDK4, MDM2
17	glomus tumor	28.0	VIM, S100A1, CD34, ACTC1, DES
18	mixed cell type cancer	28.0	VIM, PLAG1, DES
19	skin cancer	28.0	VIM, CDKN2A, CDK4, MMP3, MDM2, F3
20	perivascular epithelioid cell tumor	27.9	VIM, S100A1, CDKN2A, ACTC1, DES
21	granular cell tumor	27.8	VIM, S100A1, CD68, PTEN, DES, PROM2
22	gastrointestinal stromal tumor	27.7	VIM, S100A1, CDKN2A, CD34, PTEN, PLAG1
23	pleomorphic adenoma	27.6	VIM, S100A1, MDM2, AMACR, HMGA1, HMGA2
24	dermatofibrosarcoma protuberans	27.5	VIM, S100A1, CD34, MMP3, HMGA1, HMGA2
25	pancreatic ductal adenocarcinoma	27.4	VIM, CDKN2A, MEN1, F3, HMGA1, HMGA2
26	malignant peripheral nerve sheath tumor	27.4	VIM, S100A1, CDKN2A, CD34, MDM2
27	anaplastic large cell lymphoma	27.3	CD99, CDK4, CD68, F3, TNF, PPARG
28	angiomyolipoma	27.3	VIM, S100A1, CDKN2A, CD68, TNF, ACTC1
29	synovial sarcoma	27.2	VIM, MDM2, HMGA2, DES
30	adenoid cystic carcinoma	27.2	VIM, S100A1, CDKN2A, CDK4, MDM2, PTEN
31	bronchogenic carcinoma	27.2	CDKN2A, MDM2, TNF, PGR
32	polymorphous low-grade adenocarcinoma	27.2	VIM, S100A1, NFIB, ACTC1
33	paraganglioma	27.1	VIM, S100A1, CDKN2A, MEN1, PTEN, ACTC1
34	adenoiditis	27.1	VIM, S100A1, CDKN2A, CD34, CDK4, MDM2
35	chromophobe renal cell carcinoma	27.0	VIM, S100A1, FLCN, PROM2
36	kidney cancer	27.0	FLCN, AMACR, TNF, PTEN, DES
37	chordoma	27.0	VIM, S100A1, CDKN2A, MDM2, PTEN, DES
38	angiosarcoma	27.0	VIM, CDKN2A, CD34, CD68, MDM2, PTEN
39	cystadenoma	26.9	VIM, S100A1, PTEN, ACTC1, PGR
40	basal cell carcinoma	26.9	CDKN2A, CD34, CD68, MMP3, MDM2, TNF
41	pleomorphic xanthoastrocytoma	26.7	CDKN2A, CD34, CDK4, CD68, MDM2
42	pancreatic ductal carcinoma	26.6	SERPINE1, VIM, CDKN2A, MDM2, PTEN, ACTC1
43	giant cell tumor	26.6	VIM, CD34, CD68, TNF, ACTC1, TGFB2
44	dermatofibrosarcoma	26.6	VIM, S100A1, CD34, MMP3, MDM2, HMGA1
45	familial adenomatous polyposis	26.5	SERPINE1, VIM, CDK4, PTEN, DDIT3, PPARG
46	wilms tumor	26.5	VIM, CDKN2A, CDK4, MEN1, AMACR, TNF
47	meningioma	26.4	SERPINE1, VIM, UBE2D1, S100A1, CDKN2A, CD34
48	thyroid cancer	26.4	VIM, S100A1, CDKN2A, MMP3, INS, MEN1
49	malignant mesothelioma	26.4	VIM, S100A1, CDKN2A, CD34, CDK4, MMP3
50	mantle cell lymphoma	26.4	CDKN2A, CDK4, MDM2, TNF, PTEN, PPARG

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

MalaCards organs/tissues related to lipoma:

²²

MGI Mouse Phenotypes related to lipoma:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	INF	PTEN, TNF, F3, MAP2K2, , DLK1
2	homeostasis/metabolism phenotype	MP:0005376	INF	PGR, HMGA1, HMGA2, TNF, PTEN, DLK1
3	immune system phenotype	MP:0005387	INF	, GHR, HMGA1, TNF, DLK1, DDIT3
4	endocrine/exocrine gland phenotype	MP:0005379	9.6	PPP1CC, HMGA2, GHR, MEN1, FUS
5	integument phenotype	MP:0010771	9.4	TGM1, HMGA2, F3, MDM2, CDK4, CD34
6	reproductive system phenotype	MP:0005389	9.2	PLAG1, PPP1CC, SPTLC1, DLK1, TNF, HMGA2
7	embryogenesis phenotype	MP:0005380	9.0	PGR, TGFB2, PLAG1, PPP1CC, MDM2, MEN1
8	liver/biliary system phenotype	MP:0005370	8.9	LTBP1, GHR, AMACR, MEN1, INS, MKL2
9	tumorigenesis	MP:0002006	7.5	PGR, PPARG, PTEN, TNF, HMGA1, F3
10	adipose tissue phenotype	MP:0005375	7.3	PPARG, DLK1, PTEN, TNF, HMGA2, GHR
11	skeleton phenotype	MP:0005390	6.8	PGR, TGFB2, LTBP1, PPARG, DLK1, PTEN
12	behavior/neurological phenotype	MP:0005386	6.3	DDIT3, SPRED1, SPTLC1, PPARG, CRLF1, TGM1
13	growth/size phenotype	MP:0005378	6.0	PTEN, HMGA2, HMGA1, GHR, DLK1, SPRED1
14	vision/eye phenotype	MP:0005391	6.0	DLK1, PPARG, PLAG1, NFIB, TGFB2, SLC17A5
15	mortality/aging	MP:0010768	5.8	DLK1, SPTLC1, PPARG, CRLF1, NFIB, LTBP1
16	nervous system phenotype	MP:0003631	4.2	SPTLC1, SPRED1, DDIT3, PTEN, TNF, PPARG
17	cardiovascular system phenotype	MP:0005385	INF	HMGA1, TNF, PTEN, PPARG, LTBP1, ACTC1
18	hematopoietic system phenotype	MP:0005397	INF	DLK1, SPRED1, CRLF1, CXCR7, MDM2, FBLIM1
19	muscle phenotype	MP:0005369	INF	PTEN, DLK1, PPARG, LTBP1, ACTC1, TGFB2

Articles related to lipoma:

(show top 50)    (show all 67)

id	Title	Authors	Year	Affiliating Genes
1	Let-7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data. (21412931)	Bianchini L.... Pedeutour F.	2011	HMGA2, MIRLET7A1
2	C11orf95-MKL2 is the resulting fusion oncogene of t(1 1;16)(q13;p13) in chondroid lipoma. (20607705)	Huang D.... Bridge J.A.	2010	MKL2, C11orf95
3	Well-differentiated spindle cell liposarcoma ('atypic al spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopa thologic, immunohistochemical, and molecular analysis of six cases. (20228779)	Mentzel T.... Kuhnen C.	2010	CDK4, MDM2
4	Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues. (19963137)	Wang X.... Oliveira A.M.	2010	HMGA2
5	Haploinsufficiency of the LIM domain containing prefe rred translocation partner in lipoma (LPP) gene in patients with tetralogy of F allot and VACTERL association. (20949626)	Arrington C.B.... Bowles N.E.	2010	LPP
6	Lipoma and atypical lipomatous tumor within the same neoplasia: Evidence for a continuous transition (20063101)	Kuhnen C.... Debiec-Rychter M.	2010	CDK4
7	Expression of HMGA2-LPP and LPP-HMGA2 fusion genes in lipoma: identification of a novel type of LPP-HMGA2 transcript in four cases. (19528502)	Kubo T.... Ueda T.	2009	HMGA2
8	Retroperitoneal lipomatous tumors without cytologic a typia: are they lipomas? A clinicopathologic and molecular study of 19 cases. (19654500)	Macarenco R.S.... Oliveira A.M.	2009	HMGA2
9	Differential diagnosis of lipoma-like lipoblastoma. (18798558)	Morerio C.... Panarello C.	2009	PLAG1
10	Spindle cell/pleomorphic lipoma of the oral cavity. (19881383)	Vecchio G.... Magro G.	2009	PGR
11	Clinicopathological features of lipomas with gene fusions involving HMGA2. (18383898)	Hatano H.... Sato T.	2008	HMGA2
12	Assessment of the clinical and molecular impact of different cytogenetic subgroups in a series of 272 lipomas with abnormal karyotype. (17370328)	Bartuma H.... Mertens F.	2007	HMGA1, HMGA2, PLAG1
13	Gains and complex rearrangements of the 12q13-15 chromosomal region in ordinary lipomas: the 'missing link' between lipomas and liposarcomas? (17372913)	Italiano A.... Pedeutour F.	2007	CDK4, MDM2, HMGA2
14	Spindle cell lipoma. (17585537)	Comunoglu N.... DerviA9oglu S.	2007	DES
15	Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration. (17322171)	Jin L.... Somlyo A.V.	2007	LPP, PALLD
16	Cutaneous lipoma in children: 5 cases with Bannayan-Riley-Ruvalcaba syndrome. (16952599)	Buisson P.... Heloury Y.	2006	PTEN
17	Sclerotic (fibroma-like) lipoma: a distinctive lipoma variant with a predilection for the distal extremities. (16871033)	Laskin W.B.... Miettinen M.	2006	ACTC1, S100A1
18	Truncation and fusion of HMGA2 in lipomas with rearrangements of 5q32-->q33 and 12q14-->q15. (16276091)	Nilsson M.... Panagopoulos I.	2006	HMGA2
19	Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas. (15593017)	Ligon A.H.... Morton C.C.	2005	HMGA2
20	Fusion of the HMGA2 and NFIB genes in lipoma. (16133369)	Nilsson M.... Mandahl N.	2005	HMGA2
21	Well-differentiated liposarcoma associated with benign lipoma. (15154619)	Hatano H.... Honma K.	2004	CDK4
22	Desmin expression in spindle cell lipomas: a potential diagnostic pitfall. (15322874)	TardA-o J.C.... Santonja C.	2004	DES, S100A1
23	Spindle cell lipoma in an intramuscular lipoma. (15363044)	Usta U.... Guzel Z.	2004	S100A1
24	The lipoma preferred partner LPP interacts with alpha-actinin. (12615977)	Li B.... Trueb B.	2003	ACTN1, LPP
25	The focal adhesion and nuclear targeting capacity of the LIM- containing lipoma-preferred partner (LPP) protein. (12441356)	Petit M.M.... Van De Ven W.J.M.	2003	LPP
26	Immunohistochemical study of chondrolipoma: possible importance of transforming growth factor (TGF)-betas, latent TGF-beta binding protein-1 (LTBP-1), and bone morphogenetic protein (BMP) for chondrogenesis in lipoma. (12692354)	Nakano M.... Hirose T.	2003	TGFB2, LTBP1
27	Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15. (12118328)	Broberg K.... Panagopoulos I.	2002	CXCR7
28	Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favor of a unifying histogenetic concept. (11889594)	Magro G.... Eusebi V.	2002	DES, CD99
29	Multiple lipomas linked to an RB1 gene mutation in a large pedigree with low penetrance retinoblastoma. (11571558)	Genuardi M.... Lohmann D.R.	2001	PTEN, MEN1
30	Role of the high mobility group A proteins in human lipomas. (11576996)	Fedele M.... Fusco A.	2001	HMGA2
31	Distinction between lipoma and liposarcoma by MDM2 alterations: a case report of simultaneously occurring tumors and review of the literature. (11518050)	Boltze C.... Roessner A.	2001	MDM2
32	A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas. (12063392)	Lemke I.... Bullerdiek J.	2001	LPP, HMGA2, C12orf9
33	Large deletion of part of the HMGIC locus accompanying a t(3;12)(q27 approximately q28;q14 approximately q15) in a lipoma. (11566348)	Lemke I.... Bullerdiek J.	2001	HMGA2
34	Transgenic mice expressing a truncated form of the high mobility group I-C protein develop adiposity and an abnormally high prevalence of lipomas. (10747931)	Arlotta P.... Ono S.J.	2000	HMGA2
35	The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma. (10755400)	Pilotti S.... Pierotti M.A.	2000	CDK4, MDM2
36	Expression of growth hormone receptor in human liposa rcomas and lipomas. (10854539)	Temmim L.... Sinowatz F.	2000	GHR
37	Uncoupling protein-1 mRNA expression in lipomas from patients bearing pathogenic mitochondrial DNA mutations. (11095987)	Vila M.R.... Villarroya F.	2000	UCP1
38	A t(2;19)(p13;p13.2) in a giant invasive cardiac lipoma from a patient with multiple lipomatosis. (10824997)	Vaughan C.J.... Basson C.T.	2000	HMGA2
39	LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes. (10329012)	Petit M.M.R.... Van De Ven W.J.M.	1999	HMGA2, LHFP, LHFPL2
40	Multiple endocrine neoplasia 1 gene alterations in MEN1-associated and sporadic lipomas. (9498491)	Vortmeyer A.O.... Zhuang Z.	1998	MEN1
41	Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma. (9772904)	Petit M.M.... Van De Ven W.J.M.	1998	LPP, HMGA2
42	Identification of new translocation breakpoints at 12q13 in lipomas. (9403060)	Merscher S.... Turc-Carel C.	1997	HMGA2
43	Expression of HMGI-C and HMGI(Y) in ordinary lipoma and atypical lipomatous tumors: immunohistochemical reactivity correlates with karyotypic alterations. (9212729)	Tallini G.... Sciot R.	1997	HMGA1, HMGA2
44	Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas. (8889500)	Schoenberg Fejzo M.... Morton C.C.	1996	HMGA2
45	LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. (8812423)	Petit M.M.R.... Van De Ven W.J.M.	1996	LPP
46	Genomic characterization of human HMGIC, a member of the accessory transcription factor family found at translocation breakpoints in lipomas. (8824803)	Ashar H.R.... Chada K.	1996	HMGA1, HMGA2
47	Chondroid lipoma: an ultrastructural and immunohistochemical analysis with further observations regarding its differentiation. (7628841)	Kindblom L.G.... Meis-Kindblom J.M.	1995	CD68
48	Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. (7606786)	Ashar H.R.... Chada K.	1995	HMGA2
49	Putative apolipoprotein receptor gene (LRP, A2MR) is not rearranged in either myxoid liposarcoma or lipomas with translocations in 12q13-14. (1318779)	Paulien S.... Gemmill R.M.	1992	LRP1
50	Effect of insulin and carbenoxolone on adrenaline sti mulated lipolysis in human lipoma. (2079320)	GA^mez-Capilla J.A.... FernA!ndez-FernA!ndez J.M.	1990	INS

Genes related to lipoma according to GeneCards:

(show top 50)    (show all 65)

id	Symbol	Description	Score	GeneCards Section Context
1	LHFPL3	lipoma HMGIC fusion partner-like 3	11.1	Functions, Proteins, Aliases & Descriptions, Publications (show all 7 sections) Summaries, Orthologs, Transcripts
2	LHFPL1	lipoma HMGIC fusion partner-like 1	11.1	Publications, Functions, Proteins, Aliases & Descriptions (show all 7 sections) Orthologs, Summaries, Transcripts
3	LHFPL4	lipoma HMGIC fusion partner-like 4	11.1	Summaries, Proteins, Orthologs, Aliases & Descriptions (show all 6 sections) Functions, Transcripts
4	LHFPL2	lipoma HMGIC fusion partner-like 2	11.1	Summaries, Orthologs, Publications, Proteins (show all 7 sections) Functions, Aliases & Descriptions, Transcripts
5	LHFP	lipoma HMGIC fusion partner	11.1	Orthologs, Transcripts, Publications, Aliases & Descriptions (show all 7 sections) Summaries, Functions, Proteins
6	LHFPL5	lipoma HMGIC fusion partner-like 5	11.1	Transcripts, Aliases & Descriptions, Orthologs, Summaries (show all 5 sections) Publications
7	LPP	LIM domain containing preferred translocation partner in lipoma	11.1	Proteins, Transcripts, Publications, Aliases & Descriptions (show all 6 sections) Orthologs, Functions
8	CXCR7	chemokine (C-X-C motif) receptor 7	11.0	Publications, Summaries
9	MEN1	multiple endocrine neoplasia I	11.0	Publications
10	HMGA2	high mobility group AT-hook 2	11.0	Publications
11	S100A1	S100 calcium binding protein A1	11.0	Publications
12	DES	desmin	11.0	Publications
13	CDK4	cyclin-dependent kinase 4	11.0	Publications
14	CD34	CD34 molecule	11.0	Publications
15	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
16	C11orf95	chromosome 11 open reading frame 95	11.0	Publications
17	PROM2	prominin 2	11.0	Publications
18	MED19	mediator complex subunit 19	11.0
19	CRLF1	cytokine receptor-like factor 1	11.0
20	TRIP6	thyroid hormone receptor interactor 6	11.0
21	CD99	CD99 molecule	11.0	Publications
22	CD68	CD68 molecule	11.0	Publications
23	PLAG1	pleiomorphic adenoma gene 1	11.0	Publications
24	HMGA1	high mobility group AT-hook 1	11.0	Publications
25	ZYX	zyxin	11.0	Orthologs
26	UBE2D1	ubiquitin-conjugating enzyme E2D 1	11.0
27	AMACR	alpha-methylacyl-CoA racemase	11.0
28	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
29	UCP1	uncoupling protein 1 (mitochondrial, proton carrier)	11.0	Publications
30	SPTLC1	serine palmitoyltransferase, long chain base subunit 1	11.0
31	MKL2	MKL/myocardin-like 2	11.0	Publications
32	MSRB3	methionine sulfoxide reductase B3	11.0
33	DDIT3	DNA-damage-inducible transcript 3	11.0
34	NFIB	nuclear factor I/B	11.0	Publications
35	FUS	fused in sarcoma	11.0
36	DUSP19	dual specificity phosphatase 19	11.0
37	PTEN	phosphatase and tensin homolog	11.0	Publications
38	VIM	vimentin	11.0	Publications
39	PGR	progesterone receptor	11.0	Publications
40	C12orf9	chromosome 12 open reading frame 9	11.0	Publications
41	TSPAN31	tetraspanin 31	11.0	Publications
42	MIRLET7A1	microRNA let-7a-1	11.0	Publications
43	FBLIM1	filamin binding LIM protein 1	11.0	Orthologs
44	DLK1	delta-like 1 homolog (Drosophila)	11.0	Publications
45	FLCN	folliculin	11.0
46	CPM	carboxypeptidase M	11.0	Publications
47	SPRED1	sprouty-related, EVH1 domain containing 1	11.0
48	TGM1	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)	11.0
49	PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	11.0
50	ACTN1	actinin, alpha 1	11.0	Publications

Pathways related to lipoma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Cytoskeletal Signaling3	INF	DES, ACTN1, ACTC1, , , LPP
2	Glioblastoma Multiforme36	9.7	PTEN, MAP2K2, MDM2, CDK4
3	Glioma20	9.6	PTEN, MAP2K2, MDM2, CDK4, CDKN2A
4	Melanoma20	9.6	PTEN, MAP2K2, MDM2, CDK4, CDKN2A
5	Bladder cancer20	9.5	MAP2K2, MDM2, CDK4, CDKN2A
6	p53 signaling pathway20	9.5	SERPINE1, CDKN2A, CDK4, MDM2, PTEN
7	Chronic myeloid leukemia20	9.4	TGFB2, MAP2K2, MDM2, CDK4, CDKN2A
8	Germ Cell-Sertoli Cell Junction Dynamics36	9.1	MAP2K2, TNF, ZYX, ACTN1, TGFB2
9	Pathways in cancer20	INF	CDK4, MDM2, , PTEN
10	Pancreatic Adenocarcinoma36	INF	CDKN2A, TGFB2, LTBP1, MAP2K2, MDM2,

Compounds related to lipoma according to GeneDecks:

(show top 50)    (show all 104)

id	Compound	Score	Top Affiliating Genes
1	progestin32	10.4	DES, VIM, CDK4
2	reticulin32	10.3	DES, CD34, VIM, ACTC1
3	mucicarmine32	10.3	VIM, S100A1, DES, ACTC1
4	glucose32	9.8	CDK4, DES, TGFB2, ACTC1, LTBP1, DLK1
5	gemfibrozil32 9 9	11.8	INS, DES, VIM
6	estradiol32 9 18 9	12.5	PGR, DES, TGFB2, PTEN, SERPINE1, VIM
7	dihydrotestosterone32 9 18 9	12.3	PGR, TGFB2, SERPINE1, VIM, CDK4, GHR
8	agar32	9.3	PTEN, PGR, TGFB2, MDM2, CDK4, CD34
9	rapamycin32 42	10.3	VIM, CDK4, FLCN, INS, MDM2, DUSP19
10	doxorubicin32 34 9 9	12.3	HMGA2, DUSP19, PGR, DES, PTEN, MDM2
11	procollagen32	9.3	MMP3, VIM, GHR, ACTC1, DES, SLC17A5
12	cysteine32	9.2	DUSP19, UCP1, S100A1, CDKN2A, MDM2, AMACR
13	n acetylcysteine32	9.2	CDKN2A, CDK4, MMP3, DUSP19, SLC17A5
14	hematoxylin32	9.1	S100A1, ACTC1, PTEN, AMACR, CD34, CDKN2A
15	lovastatin32 42 9 9	12.1	SERPINE1, CDKN2A, CDK4, HMGA1, PTEN, LRP1
16	creatinine32	9.1	F3, DES, ACTC1, GHR, MMP3, CDKN2A
17	mg 13232 42	9.9	PTEN, DUSP19, TNF, GHR, CDKN2A, MDM2
18	testosterone32 9 18 9	11.9	PTEN, PGR, DES, TGFB2, AMACR, DDIT3
19	nitric oxide32 9 18 9	11.9	S100A1, CDK4, CDKN2A, UCP1, GHR, DDIT3
20	aspartate32	8.9	VIM, UCP1, PGR, CDKN2A, GHR, DUSP19
21	sodium dodecylsulfate32	8.8	SERPINE1, PGR, DES, TGM1, LRP1, GHR
22	cyclic amp32 18	9.7	DUSP19, UCP1, GHR, TGFB2, DLK1, DES
23	tgf beta132	8.5	CDK4, VIM, LRP1, SERPINE1, MMP3, TNF
24	nash32	8.4	ACTC1, TNF, INS, SLC17A5
25	bezafibrate32 9 9	10.4	INS, DES, PPARG, SERPINE1, SLC17A5, UCP1
26	paraffin32	8.4	MDM2, VIM, S100A1, PGR, CDKN2A, CD34
27	vitamin d32	8.3	MEN1, MMP3, CDK4, LRP1, VIM, SERPINE1
28	iron32 18	9.2	CDK4, SLC17A5, MMP3, CDKN2A, MDM2, DES
29	sb 20358032 42	9.1	PPARG, DDIT3, TNF, F3, MMP3, VIM
30	methotrexate32 34 42 9 9	12.1	SERPINE1, PGR, SLC17A5, VIM, TNF, MDM2
31	simvastatin32 34 42 9 18 9	13.0	F3, SERPINE1, MMP3, SLC17A5, PPARG, TNF
32	actinomycin d32	8.0	VIM, HMGA2, F3, MDM2, CDKN2A, TNF
33	fenofibrate32 9 9	9.9	PPARG, INS, SERPINE1, VIM, SLC17A5, DES
34	glycogen32 18	8.9	S100A1, CDK4, DUSP19, PPP1CC, INS, LRP1
35	progesterone32 42 9 18 9	11.9	MMP3, MDM2, AMACR, GHR, PTEN, TGFB2
36	genistein32 9 18 9	10.7	TNF, CDKN2A, CDK4, SERPINE1, PTEN, DDIT3
37	rosiglitazone32 9 18 9	10.7	SLC17A5, LRP1, SERPINE1, UCP1, INS, TNF
38	troglitazone32 42 9 9	10.6	SLC17A5, TNF, INS, MMP3, CDK4, SERPINE1
39	tacrolimus32 34 9 9	10.3	SERPINE1, DUSP19, PPARG, SLC17A5, PGR, F3
40	fatty acid32	7.2	LRP1, HMGA1, GHR, SLC17A5, DES, TGFB2
41	vegf32	6.8	PTEN, TNF, MDM2, MEN1, F3, CDK4
42	cholesterol32 9 18 9	9.7	SLC17A5, PPARG, SPTLC1, PTEN, UCP1, SERPINE1
43	cycloheximide32	6.7	VIM, DUSP19, GHR, F3, MDM2, MMP3
44	alanine32	6.6	MDM2, VIM, UCP1, CDKN2A, CDK4, SLC17A5
45	retinoic acid32 42 18	8.5	GHR, LRP1, SERPINE1, UCP1, CDKN2A, CD34
46	estrogen32	6.4	LTBP1, PPARG, CD34, DUSP19, GHR, AMACR
47	dexamethasone32 42 34 9 9	10.3	DLK1, PPARG, ACTC1, TGFB2, LRP1, DUSP19
48	serine32	5.8	DUSP19, PTEN, TGFB2, MAP2K2, SPTLC1, TNF
49	tyrosine32	INF	DES, , SLC17A5, MMP3, MAP2K2, MDM2
50	lipid32	INF	HMGA1, AMACR, , INS, MMP3, CD68

Cellular components related to lipoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	INF	F3, TRIP6, TPRG1, PTEN, DDIT3, SPRED1
2	senescence-associated heterochromatin focus	GO:035985	9.5	HMGA2, HMGA1, CDKN2A
3	focal adhesion	GO:005925	9.1	LPP, PALLD, FBLIM1, MAP2K2, TRIP6, ZYX

Biological processes related to lipoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	oncogene-induced senescence	GO:090402	10.2	HMGA1, HMGA2
2	senescence-associated heterochromatin focus assembly	GO:035986	9.9	CDKN2A, HMGA1, HMGA2
3	positive regulation of cellular senescence	GO:2000774	9.9	HMGA2, HMGA1, CDKN2A
4	negative regulation of gene expression	GO:010629	9.7	CD34, TNF, PLAG1, PGR
5	transforming growth factor beta receptor signaling pathway	GO:007179	9.1	TGFB2, PPP1CC, MEN1, UBE2D1, SERPINE1
6	negative regulation of apoptotic process	GO:043066	8.1	CXCR7, TGFB2, PTEN, TNF, HMGA2, MDM2

Molecular functions related to lipoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	PGR, HMGA1, HMGA2, TRIP6, TNF, PTEN
2	protease binding	GO:002020	8.3	SERPINE1, INS, F3, TNF