MCID: LPM004
MIFTS: 64

Lipoma malady

Genetic diseases, Skin diseases, Rare diseases, Cancer diseases categories
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Summaries for Lipoma

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Sources:
8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 A lipoma is a benign tumor composed of adipose tissue (body fat). It is the most common benign form of... more...

MalaCards: Lipoma, also known as familial multiple lipomatosis, is related to liposarcoma and lipomatosis. An important gene associated with Lipoma is LPP (LIM domain containing preferred translocation partner in lipoma), and among its related pathways are DNA damage ATM ATR regulation of G1 S checkpoint and RB in Cancer. The compounds leptomycin b and roscovitine have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and spinal cord, and related mouse phenotypes are behavior/neurological and reproductive system.

Disease Ontology:8 A cell type benign neoplasm that is composed of lipocytes.

Description from OMIM:47 151900

Aliases & Classifications for Lipoma

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8Disease Ontology, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 27ICD9CM, 58SNOMED-CT, 35MeSH, 40NCIt, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Skin diseases
Orphanet: 49 
Rare skin diseases


Aliases & Descriptions:

lipoma 8 47 10 45 62
familial multiple lipomatosis 49 47
benign lipomatous tumor 8 62
lipomatous neoplasm 8 62
lipomatosis, familial multiple 8
benign tumor of adipose tissue 8
benign symmetrical lipomatosis 62
tumor of adipose tissue 8
lipomatous neoplasm nos 8
multiple lipomatosis 8
lipomatous tumor 8


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Disease Ontology8 DOID:3315
ICD9CM27 214, 214.9
OMIM47 151900
MeSH35 D008067
NCIt40 C3192
ICD10 via Orphanet26 E88.2

Related Diseases for Lipoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 402)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma30.7CDK4, MDM2, HMGA2, DES
2lipomatosis30.6HMGA2, MEN1
3myxoid liposarcoma30.2CDK4, MDM2
4adenoma30.1CDK4, HMGA2, MEN1
5leiomyoma30.1DES, HMGA2
6dermatofibrosarcoma30.0MDM2
7dedifferentiated liposarcoma29.9DES, HMGA2, MDM2, CDK4
8ependymoma29.9MEN1, MDM2
9pleomorphic adenoma29.9MDM2, HMGA2, DES
10adenocarcinoma29.9MEN1, HMGA2, MDM2, CDK4
11retinoblastoma29.8MEN1, MDM2, CDK4
12hemangiopericytoma29.7MDM2, DES
13chondroma29.7HMGA2, LPP, LHFP
14b-cell lymphomas29.6CDK4, MDM2, HMGA2
15leiomyosarcoma29.6CDK4, MDM2, DES
16pituitary adenoma29.6CDK4, HMGA2, MEN1
17chondrosarcoma29.6CDK4, MDM2, HMGA2, DES
18sarcoma29.6CDK4, MDM2, HMGA2, DES
19spindle cell lipoma10.8
20pleomorphic lipoma10.7
21endobronchial lipoma10.7
22chondroid lipoma10.6
23infiltrating lipoma10.5
24intussusception10.5
25lumbosacral lipoma10.5
26pleural lipoma10.4
27spinal cord lipoma10.4
28esophageal lipoma10.4
29atypical lipomatous tumor10.3
30nasopalpebral lipoma coloboma syndrome10.3
31breast lipoma10.3
32esophagitis10.3
33corpus callosum lipoma10.3
34skin lipoma10.3
35angiolipoma10.3
36duodenitis10.2
37intestinal obstruction10.2
38neuropathy10.2
39familial angiolipomatosis10.2
40chest wall lipoma10.2
41axillary lipoma10.2
42mediastinitis10.2
43coloboma10.2
44cervicitis10.2
45laryngitis10.2
46lipoblastoma10.2
47madelung disease10.2
48hemifacial spasm10.2
49nasopalpebral lipoma - coloboma - telecanthus10.2
50neurofibromatosis10.1

Graphical network of the top 20 diseases related to Lipoma:



Diseases related to lipoma

Symptoms for Lipoma

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Sources:
47OMIM
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Symptoms by clinical synopsis from OMIM:

151900

Clinical features from OMIM:

151900

Drugs & Therapeutics for Lipoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Lipoma

Search NIH Clinical Center for Lipoma

Genetic Tests for Lipoma

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Anatomical Context for Lipoma

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Sources:
33MalaCards
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MalaCards organs/tissues related to Lipoma:

33
Colon, Breast, Spinal cord, Tongue, Skin, Bone, Pancreas, Lung, Liver, Adipocyte, Adrenal gland, Heart, Small intestine, Brain, Pituitary, Salivary gland, Prostate, Appendix, B cells, Smooth muscle, Testes, Uterus, Kidney, Ovary, Cerebellum

Animal Models for Lipoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Lipoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.9DES, LHFPL5, HMGA2, MDM2, CDK4
2MP:00053897.7CDK4, MDM2, HMGA2, MEN1, LPP
3MP:00053697.7DES, MEN1, MDM2, CDK4
4MP:00036317.7CDK4, MDM2, HMGA2, MEN1, LHFPL5

Publications for Lipoma

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52PubMed
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Articles related to Lipoma:

(show top 50)    (show all 990)
idTitleAuthorsYear
1
Ischemic stroke and incidental finding of a right atrial lipoma. (24149062)
2013
2
Cyclin-dependent kinase inhibitor 2A (p16) distinguishes well-differentiated liposarcoma from lipoma. (23600700)
2013
3
Gastric lipoma and pyloric obstruction in a 51-year-old woman. (23648507)
2013
4
Torsion of an abdominal-wall pedunculated lipoma: a rare differential diagnosis for right iliac fossa pain. (23781377)
2013
5
Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma:report of a case. (24166610)
2013
6
Laparoscopic enucleation of a giant submucosal esophageal lipoma. Case report and literature review. (23826462)
2013
7
Parosteal lipoma Report of 15 new cases and a review of the literature. (23698599)
2013
8
Transoral robotic surgery for huge spindle cell lipoma of the hypopharynx. (23851787)
2013
9
A massive posterior neck mass: lipoma or something more sinister? (24223314)
2013
10
Lipoma or liposarcoma? A cautionary case report. (21865105)
2012
11
Intracranial lipoma with subgaleal extension: An interesting case report with review of literature. (22954994)
2012
12
Pleomorphic lipoma lacking mature fat component in extensive myxoid stroma: a great diagnostic challenge. (23148444)
2012
13
Multiple giant nerve abscesses presenting like lipoma in a treated patient of Hansen's disease. (22715828)
2012
14
A giant cardiac lipoma associated with ventricular inversion and ventricular aneurysm: ultrasonography and CT imaging findings. (22215833)
2012
15
Intra-osseous lipoma of the talus: a case report. (22535830)
2012
16
Parosteal ossifying lipoma of the fibula: a case report with contrast-enhanced MR study and a review of the literature. (22941147)
2012
17
Diagnostics of peripherally located intrathoracic lipoma. (23322965)
2012
18
The first case of renal lipoma in a child. (21683239)
2011
19
Spindle cell lipoma with collagen rosettes. (21645033)
2011
20
Solitary plexiform neurofibroma, a pitfall in diagnosis of lipoma. (22778282)
2010
21
Spindle cell lipoma of the orbit: a case report of an unusual orbital pathology. (20827617)
2010
22
Surgical Removal of lipoma from an area with tattooed skin. (21103075)
2010
23
Spinal cord lipoma without dysraphism in the infancy that extends intracranially. Case report and review of the literature. (18291460)
2009
24
Cellular and molecular features of lipoma tissue: comparison with normal adipose tissue. (19558598)
2009
25
Spindle cell lipoma breast. (18603691)
2008
26
Mutations in the lipoma HMGIC fusion partner-like 5 (LHFPL5) gene cause autosomal recessive nonsyndromic hearing loss. (16752389)
2006
27
Prognostic factors affecting urologic outcome after untethering surgery for lumbosacral lipoma. (16586137)
2006
28
Spindle cell lipoma of the floor of the mouth. A case report. (16878055)
2006
29
Pathology quiz case 2. Spindle cell lipoma. (16490884)
2006
30
Intramedullary migration of spinal cord lipoma. (14617729)
2003
31
Lipoma arborescens (diffuse articular lipomatosis). (14577726)
2003
32
Non-dysraphic intramedullary spinal cord lipoma. A case report. (12477239)
2002
33
Neurologic variant of epidermal nevus syndrome with a facial lipoma. (11422522)
2001
34
Sciatic neuropathy secondary to infiltrating intermuscular lipoma of the thigh. (11562557)
2001
35
Spindle cell lipoma of the hypopharynx. (11453572)
2001
36
The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma. (10755400)
2000
37
Expression of growth hormone receptor in human liposarcomas and lipomas. (10854539)
2000
38
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
39
Spindle-cell lipoma of the preseptal eyelid. (9612807)
1998
40
Endobronchial lipoma: a report of three cases. (8551668)
1996
41
Chondroid lipoma: an ultrastructural and immunohistochemical analysis with further observations regarding its differentiation. (7628841)
1995
42
Infiltrating lipoma of the chest wall. (8255655)
1993
43
Neurocytoma/lipoma (neurolipocytoma) of the cerebellum. (8474606)
1993
44
Spinal neurenteric cyst. Association with vertebral anomalies, diastematomyelia, dorsal fistula, and lipoma. (6701769)
1984
45
Spindle cell lipoma. (6487132)
1984
46
Cervical spinal cord lipoma with extension into the posterior fossa. (6856073)
1983
47
Endobronchial lipoma. A case report. (483103)
1979
48
Endobronchial lipoma associated with squamous metaplasia of bronchial mucosa. (1124014)
1975
49
Lipoma of the rectum. (14006359)
1962
50
Agenesis of the corpus callosum; lipoma of the corpus callosum; their roentgen recognition and differentiation. (14854179)
1951

Variations for Lipoma

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Expression for genes affiliated with Lipoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipoma

Search GEO for disease gene expression data for Lipoma.

Pathways for genes affiliated with Lipoma

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Sources:
50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 54R&D Systems, 55Reactome
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Compounds for genes affiliated with Lipoma

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45Novoseek, 61Tocris Bioscience, 51PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
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Compounds related to Lipoma according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1leptomycin b45 6110.9LPP, MDM2
2roscovitine459.6MDM2, CDK4
3benzo(a)pyrene459.6CDK4, MDM2
4fludarabine45 51 1111.6CDK4, MDM2
5flavopiridol45 1110.6CDK4, MDM2
6trastuzumab45 51 1111.6CDK4, MDM2
7gefitinib45 51 1111.5CDK4, MDM2
8progestin459.4CDK4, DES
9nad+459.4MDM2, DES
10actinomycin d459.3DES, HMGA2, MDM2
11carboplatin45 51 1111.2MDM2, CDK4
12adpribose459.2DES, MDM2, CDK4
13glycogen45 2410.1CDK4, MDM2, DES
14estradiol45 24 1111.1CDK4, MDM2, DES
15proline459.1CDK4, MDM2, DES
16iron45 2410.1CDK4, MDM2, DES
17cisplatin45 51 61 1112.1CDK4, MDM2, HMGA2
18geldanamycin45 51 61 1112.0CDK4, MDM2
19cyclic amp45 2410.0DES, MDM2, CDK4
20progesterone45 29 61 24 1112.8DES, MDM2, CDK4
21doxorubicin45 51 1110.7CDK4, MDM2, HMGA2, DES
22paraffin458.7CDK4, MDM2, HMGA2, DES
23thymidine45 249.3CDK4, MDM2, MEN1, DES
24vegf458.3DES, MEN1, MDM2, CDK4
25estrogen458.3DES, MEN1, MDM2, CDK4
26serine458.1DES, MEN1, MDM2, CDK4

GO Terms for genes affiliated with Lipoma

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16Gene Ontology
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Cellular components related to Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:0007859.0CDK4, MEN1
2nucleoplasmGO:0056547.8CDK4, MDM2, HMGA2, MEN1

Biological processes related to Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:0711579.3CDK4, MDM2
2negative regulation of transcription from RNA polymerase II promoterGO:0001228.7MDM2, HMGA2, MEN1
3positive regulation of apoptotic processGO:0430658.5CDK4, HMGA2, MEN1
4negative regulation of transcription, DNA-templatedGO:0458928.4MEN1, HMGA2, MDM2

Molecular functions related to Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.2CDK4, MDM2, HMGA2, MEN1, LPP, DES

Products for genes affiliated with Lipoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lipoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet