Aliases & Classifications for Lipomatosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 61UMLS, 56SNOMED-CT, 33MeSH, 25ICD10
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Aliases & Descriptions for Lipomatosis:

Name: Lipomatosis 8 10 44 61
 
Benign Symmetrical Lipomatosis 61


Classifications:



External Ids:

Disease Ontology8 DOID:3153
MeSH33 D008068
SNOMED-CT56 37095002, 402693001
ICD1025 E88.2

Summaries for Lipomatosis

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Wikipedia:64 Lipomatosis is believed to be an autosomal dominant condition in which multiple lipomas are present on... more...

MalaCards based summary: Lipomatosis, also known as benign symmetrical lipomatosis, is related to pelvic lipomatosis and lipoma. An important gene associated with Lipomatosis is HMGA2 (high mobility group AT-hook 2), and among its related pathways are Adipogenesis and Chromatin Regulation / Acetylation. The compounds pgc1 and thenoyltrifluoroacetone have been mentioned in the context of this disorder. Affiliated tissues include thyroid, spinal cord and tongue, and related mouse phenotypes are digestive/alimentary and vision/eye.

Related Diseases for Lipomatosis

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Diseases related to Lipomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1pelvic lipomatosis31.9HMGA1, HMGA2
2lipoma30.8PTEN, MEN1, UCP1, HMGA1, HMGA2
3mitochondrial disorders30.6COX5A, SDHB
4merrf syndrome30.4SDHB, COX5A
5cowden disease30.4PIK3CA, PTEN
6multiple endocrine neoplasia30.0MEN1, PRKAR1A, SDHB
7pituitary adenoma30.0PRKAR1A, MEN1, HMGA2
8tuberous sclerosis29.7PIK3CA, PTEN, GSR
9adenocarcinoma29.5PIK3CA, PTEN, CEL, MEN1, ACTC1, HMGA1
10adenoma28.8PRKAR1A, MEN1, ACTC1, COX5A, GSR, HMGA1
11multiple symmetric lipomatosis10.9
12multiple symmetrical lipomatosis10.9
13encephalocraniocutaneous lipomatosis10.8
14mediastinal lipomatosis10.6
15mediastinitis10.6
16diffuse lipomatosis10.6
17cowden syndrome 110.5PTEN
18carney triad10.5SDHB
19leiomyomatosis10.5SDHB
20madelung disease10.4
21early myoclonic encephalopathy10.4COX5A, SDHB
22chondroma10.4SDHB, HMGA2
23obesity10.4
24multiple endocrine neoplasia iia10.3MEN1, SDHB
25cystitis10.3
26pancreatitis10.3
27thyroiditis10.3
28lactic acidosis10.3SDHB, COX5A
29von hippel-lindau syndrome10.3SDHB, MEN1
30pancreatic lipomatosis duodenal stenosis10.3
31roch-leri mesosomatous lipomatosis10.3
32leigh syndrome10.3SDHB, COX5A
33glomus tumor10.3ACTC1, SDHB
34breast fibroadenoma10.3HMGA1, HMGA2
35thyroid carcinoma, follicular10.3PTEN, PIK3CA
36xanthogranulomatous pyelonephritis10.3
37pyelonephritis10.3
38smooth muscle tumor10.3ACTC1, HMGA2
39carney complex variant10.2MEN1, PRKAR1A
40multiple endocrine neoplasia 110.2PRKAR1A, MEN1
41ureteral obstruction10.2
42intussusception10.2
43adiposis dolorosa10.2
44neuropathy10.2
45adrenal adenoma10.2MEN1, PRKAR1A
46pheochromocytoma10.2UCP1, MEN1, SDHB
47parathyroid adenoma10.2PRKAR1A, MEN1
48pleomorphic adenoma10.2HMGA2, HMGA1, ACTC1
49hemangioma10.2SDHB, MEN1, ACTC1
50thyroid carcinoma, papillary10.2PIK3CA, PTEN

Graphical network of the top 20 diseases related to Lipomatosis:



Diseases related to lipomatosis

Symptoms for Lipomatosis

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Drugs & Therapeutics for Lipomatosis

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Drug clinical trials:

Search ClinicalTrials for Lipomatosis

Search NIH Clinical Center for Lipomatosis

Genetic Tests for Lipomatosis

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Anatomical Context for Lipomatosis

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MalaCards organs/tissues related to Lipomatosis:

31
Thyroid, Spinal cord, Tongue, Colon, Kidney, Bone, Liver, Brain, Adipocyte, Pituitary, Small intestine, Bone marrow, Cerebellum, Heart, Lung, Pancreas, Salivary gland, Prostate, Testis, B cells, Trachea

Animal Models for Lipomatosis or affiliated genes

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Publications for Lipomatosis

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Articles related to Lipomatosis:

(show top 50)    (show all 714)
idTitleAuthorsYear
1
An unusual complication of morbid obesity: epidural lipomatosis. (25618765)
2014
2
Lipomatosis of the neck. (23524786)
2013
3
Sleep apnea-hypopnea syndrome and multiple symmetrical lipomatosis. (22974765)
2013
4
Brain lipoma, corpus callosum hypoplasia and polymicrogyria in familial multiple lipomatosis. (23116686)
2013
5
Multiple symmetric lipomatosis: a review of 3 cases. (22953128)
2012
6
Encephalocraniocutaneous Lipomatosis without Neurologic Anomalies. (23197919)
2012
7
Surgical approach in a patient with multiple symmetrical lipomatosis: case report. (22392254)
2012
8
Spinal cord stimulation in a patient with spinal epidural lipomatosis. (21332929)
2011
9
Corticosteroid-induced spinal epidural lipomatosis in the pediatric age group: report of a new case and updated analysis of the literature. (21284882)
2011
10
Papillary glioneuronal tumor present in a patient with encephalocraniocutaneous lipomatosis: case report. (20881536)
2010
11
Lipomatosis of the trigeminal nerve causing trigeminal neuralgia: case report and literature review. (21311625)
2010
12
Pelvic and retroperitoneal lipomatosis: case report. (21830459)
2010
13
Necrotizing Infiltrative Lipomatosis in a Miniature Zebu Bull (Bos primigenius indicus). (20445793)
2010
14
Spinal epidural lipomatosis: An unusual cause of relapsing and remitting paraparesis. (21559166)
2010
15
Congenital infiltrating lipomatosis. (19124289)
2009
16
Encephalocraniocutaneous lipomatosis (ECCL) in a patient with history of familial multiple lipomatosis (FML). (19215040)
2009
17
Central form of multiple symmetric lipomatosis: a case report. (19918431)
2009
18
From ancient enigmas to novel paradigms: a depiction of multiple symmetric lipomatosis. (18756923)
2008
19
Synovial lipomatosis arborescens of the peroneal tendon sheath. (18682928)
2008
20
Multiple symmetric lipomatosis type 2 in females--report of two cases. (18358107)
2008
21
Encephalocraniocutaneous lipomatosis (Haberland's syndrome): a case report of a neurocutaneous syndrome and a review of the literature. (18568254)
2008
22
Fat suppression imaging in epidural lipomatosis: case report. (17963658)
2007
23
Multiple lipomatosis--a rare cause for small bowel intussusception. (18157202)
2007
24
Lipomatous hypertrophy of the interatrial septum with cutaneous lipomatosis. (17527001)
2007
25
Spinal epidural lipomatosis caused by corticosteroid treatment in ulcerative colitis. (16490695)
2006
26
Cushing's syndrome with mediastinal lipomatosis. (15322612)
2004
27
Spinal epidural lipomatosis: a case study. (15366546)
2004
28
Lipoma arborescens (diffuse articular lipomatosis). (14577726)
2003
29
Infiltrating lipomatosis of the face: a case report and review of the literature. (12966488)
2003
30
Encephalocraniocutaneous lipomatosis syndrome in a child: association with multiple high flow cerebral arteriovenous fistulae. Case report and review. (20594485)
2002
31
Clinical picture: epidural lipomatosis. (11747940)
2001
32
Benign symmetric lipomatosis (Madelung's disease). (10854826)
2000
33
Lipomatosis of the parotid gland in a child. (11090329)
2000
34
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. (10519386)
1999
35
Diffuse intramuscular lipomatosis of a lower limb. (18521234)
1998
36
Familial multiple symmetric lipomatosis associated with the A8344G mutation of mitochondrial DNA. (9674814)
1998
37
Multiple symmetric lipomatosis presenting with polyneuropathy. (7591705)
1995
38
Encephalocraniocutaneous lipomatosis: case report and review of the literature. (8346113)
1993
39
Re: Pelvic lipomatosis associated with cystitis glandularis and adenocarcinoma of the bladder. (1569691)
1992
40
Crossed renal ectopia with pelvic lipomatosis: a new syndrome involving chromosome 1. (1511984)
1992
41
Diffuse lipomatosis involving the thoracic and abdominal wall: CT features. (1825832)
1991
42
Pancreatic lipomatosis in the Shwachman-Diamond syndrome. Identification by sonography and CT-scan. (3897999)
1985
43
CAT scan of the month. Pelvic lipomatosis. (6503281)
1984
44
Encephalocraniocutaneous lipomatosis: a recently described neurocutaneous syndrome. (6744991)
1984
45
CT-scan: a diagnostic proof for pelvic lipomatosis. (7106135)
1982
46
Pelvic lipomatosis. (7416633)
1980
47
Pelvic lipomatosis: successful surgical treatment. (4742176)
1973
48
Pelvic lipomatosis: a rare cause of suprapubic mass. (4695094)
1973
49
Pelvic lipomatosis causing urinary obstruction. (5552151)
1971
50
Congenital lipomatosis of the pancreas. Malabsorption, dwarfism, leukopenia with relative granulocytopenia and thrombocytopenia. (5665293)
1968

Variations for Lipomatosis

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Expression for genes affiliated with Lipomatosis

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Search GEO for disease gene expression data for Lipomatosis.

Pathways for genes affiliated with Lipomatosis

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Pathways related to Lipomatosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6HMGA1, UCP1, PPARGC1A
29.6HMGA2, HMGA1, MEN1
3
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
9.1PRKAR1A, PTEN, PIK3CA
4
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
8.9PPARGC1A, PIK3CA, PTEN, PRKAR1A
58.5PIK3CA, PTEN, PRKAR1A, MEN1, HMGA1
6
Show member pathways
8.2PPARGC1A, PIK3CA, SDHB, COX5A, UCP1
7
Show member pathways
6.5GSR, PPARGC1A, PIK3CA, SDHB, PTEN, PRKAR1A

Compounds for genes affiliated with Lipomatosis

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Compounds related to Lipomatosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1pgc14410.3PPARGC1A, UCP1
2thenoyltrifluoroacetone44 1111.3SDHB, UCP1
3hmga4410.2HMGA1, HMGA2
4dbds4410.2HMGA1, HMGA2
5ubiquinone449.8UCP1, SDHB, GSR
6rotenone449.8UCP1, GSR, SDHB
7rosiglitazone28 44 50 24 1113.4PPARGC1A, PIK3CA, PTEN, UCP1
8carnitine449.4UCP1, PPARGC1A, COX5A
9citrate449.3SDHB, COX5A, PPARGC1A
10aspartate449.2GSR, UCP1, PTEN, SDHB
11pyruvate449.2PPARGC1A, UCP1, SDHB, COX5A
12imatinib44 50 1111.2PIK3CA, PTEN, ACTC1
13glucose 6-phosphate44 2410.1SDHB, GSR, COX5A
14crcs449.1COX5A, PTEN, PIK3CA
15quercetin44 60 24 1112.1PIK3CA, GSR, PTEN
16linoleic acid28 44 2411.1UCP1, COX5A, CEL, PPARGC1A
17glycogen44 2410.0ACTC1, PTEN, SDHB, PIK3CA, PPARGC1A
18arsenite44 2410.0PTEN, PIK3CA, GSR
19cisplatin44 50 60 1112.0HMGA2, PTEN, GSR, PIK3CA
20ethanol44 50 24 1111.9SDHB, CEL, COX5A, PTEN
21testosterone44 60 24 1111.8SDHB, PIK3CA, PTEN, ACTC1, UCP1, PPARGC1A
22cyclic amp44 249.8PPARGC1A, PTEN, UCP1, COX5A, PRKAR1A
23hcec448.7COX5A, PIK3CA
24creatinine448.6GSR, COX5A, ACTC1, SDHB
25steroid448.6PPARGC1A, PIK3CA, PTEN, PRKAR1A, ACTC1, HMGA1
26nitric oxide44 24 1110.5COX5A, PTEN, UCP1, PIK3CA, PPARGC1A
27nadph44 249.5GSR, COX5A, PIK3CA, SDHB
28genistein44 28 60 1 24 1113.5PTEN, PIK3CA, GSR, COX5A
29lactate448.5PIK3CA, SDHB, COX5A, GSR
30progesterone44 28 60 24 1112.5ACTC1, COX5A, UCP1, PIK3CA, PTEN
31fatty acid448.4COX5A, CEL, PTEN, PPARGC1A, UCP1, HMGA1
32superoxide44 249.4PIK3CA, SDHB, COX5A, UCP1, GSR
33doxorubicin44 50 1110.4COX5A, PIK3CA, PTEN, HMGA2, GSR
34adenylate448.4PIK3CA, PRKAR1A, GSR, CEL
35tyrosine448.4PTEN, MEN1, SDHB, UCP1, HMGA1, ACTC1
36atp44 289.3COX5A, PTEN, SDHB, PPARGC1A, PIK3CA, UCP1
37dexamethasone44 50 28 1111.3PRKAR1A, PPARGC1A, PIK3CA, ACTC1, COX5A
38cysteine448.3GSR, PTEN, COX5A, UCP1, PRKAR1A, SDHB
39glucose448.1PIK3CA, SDHB, PTEN, ACTC1, UCP1, HMGA1
40glutamate448.0GSR, COX5A, UCP1, PRKAR1A, SDHB, PIK3CA
41vegf447.9COX5A, PPARGC1A, SDHB, PTEN, MEN1, ACTC1
42retinoic acid44 248.7ACTC1, HMGA1, HMGA2, PPARGC1A, PIK3CA, PTEN
43h2o2447.7PIK3CA, SDHB, PTEN, CEL, GSR, UCP1
44oxygen44 248.6UCP1, GSR, PTEN, SDHB, COX5A, ACTC1
45cholesterol44 28 24 1110.6PTEN, PPARGC1A, PIK3CA, SDHB, CEL, COX5A
46serine447.5HMGA1, UCP1, COX5A, MEN1, PPARGC1A, PIK3CA
47arginine447.4PIK3CA, SDHB, PTEN, PRKAR1A, PPARGC1A, COX5A
48estrogen447.3GSR, MEN1, PTEN, PIK3CA, COX5A, ACTC1
49calcium44 50 24 1110.3PTEN, PRKAR1A, CEL, ACTC1, UCP1, HMGA1
50lipid447.0UCP1, PTEN, PIK3CA, CEL, COX5A, GSR

GO Terms for genes affiliated with Lipomatosis

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Cellular components related to Lipomatosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1senescence-associated heterochromatin focusGO:00359859.9HMGA2, HMGA1
2cytosolGO:00058296.5HMGA1, PPARGC1A, PIK3CA, PTEN, PRKAR1A, CEL

Biological processes related to Lipomatosis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1oncogene-induced cell senescenceGO:009040210.1HMGA2, HMGA1
2senescence-associated heterochromatin focus assemblyGO:003598610.1HMGA2, HMGA1
3positive regulation of cellular senescenceGO:0200077410.1HMGA2, HMGA1
4negative regulation of organ growthGO:004662110.0MEN1, PTEN
5DNA catabolic process, endonucleolyticGO:00007379.9HMGA2, HMGA1
6positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.9PPARGC1A, PTEN, HMGA2
7brown fat cell differentiationGO:00508739.8PPARGC1A, UCP1
8endothelial cell migrationGO:00435429.6PIK3CA, PTEN
9cellular metabolic processGO:00442379.3SDHB, COX5A, UCP1
10fibroblast growth factor receptor signaling pathwayGO:00085439.3PRKAR1A, PTEN, PIK3CA
11protein kinase B signalingGO:00434919.3PTEN, PIK3CA
12epidermal growth factor receptor signaling pathwayGO:00071739.1PRKAR1A, PTEN, PIK3CA
13respiratory electron transport chainGO:00229049.1PPARGC1A, SDHB, COX5A, UCP1
14small molecule metabolic processGO:00442817.1GSR, PIK3CA, SDHB, PTEN, PRKAR1A, CEL

Molecular functions related to Lipomatosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
15-deoxyribose-5-phosphate lyase activityGO:005157510.0HMGA2, HMGA1
2AT DNA bindingGO:00036809.8HMGA1, HMGA2
3DNA-(apurinic or apyrimidinic site) lyase activityGO:00039069.6HMGA2, HMGA1
4electron carrier activityGO:00090558.9GSR, COX5A, SDHB
5protein bindingGO:00055157.2PIK3CA, SDHB, PTEN, PRKAR1A, CEL, MEN1

Sources for Lipomatosis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet