MCID: LPP002
MIFTS: 46

Lipoprotein Glomerulopathy malady

Genetic diseases, Nephrological diseases, Metabolic diseases, Endocrine diseases, Rare diseases categories

Aliases & Classifications for Lipoprotein Glomerulopathy

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Lipoprotein Glomerulopathy, Aliases & Descriptions:

Name: Lipoprotein Glomerulopathy 45 10 47 22 60
 
Lpg 47


Classifications:



Characteristics (Orphanet epidemiological data):

47
lipoprotein glomerulopathy:
Inheritance: Autosomal dominant; Age of onset: All ages


External Ids:

OMIM45 611771
Orphanet47 329481

Summaries for Lipoprotein Glomerulopathy

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OMIM:45 Lipoprotein glomerulopathy is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and... (611771) more...

MalaCards based summary: Lipoprotein Glomerulopathy, also known as lpg, is related to nephrotic syndrome and atherosclerosis, and has symptoms including renal insufficiency, proteinuria and mesangial abnormality. An important gene associated with Lipoprotein Glomerulopathy is APOE (apolipoprotein E), and among its related pathways are A-beta Uptake and Degradation and Selected targets of HNF1. The compounds tween 80 and sitosterol have been mentioned in the context of this disorder. Affiliated tissues include kidney and endothelial, and related mouse phenotypes are renal/urinary system and pigmentation.

Related Diseases for Lipoprotein Glomerulopathy

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Diseases related to Lipoprotein Glomerulopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1nephrotic syndrome30.3LCAT, APOB, APOE, ALB
2atherosclerosis29.6APOE, ALB, LDLR, LCAT, APOB
3hyperhomocysteinemia10.2ALB, APOE
4alcoholic liver cirrhosis10.2ALB, LCAT
5amyloidosis10.1ALB, APOE
6aortic disease10.1APOE, LDLR
7glomerulonephritis10.1
8gamma chain deficiency10.1
9malignant hypertension10.1
10psoriasis10.1
11endotheliitis10.1
12glomerulosclerosis10.1LCAT, ALB
13cholestasis10.1LCAT, ALB
14galactosemia10.1ALB, LDLR
15hyperlipidemia, familial combined10.1APOE, APOB
16macular degeneration, age-related, 110.1APOB, APOE
17hypertriglyceridemia10.1APOE, APOB
18arcus senilis10.1LCAT, APOB
19liver disease10.1ALB, LCAT
20peripheral vascular disease10.0ALB, APOB
21hypercholesterolemia, familial10.0LDLR, APOB
22primary hyperoxaluria10.0ALB, LCAT
23arteriosclerosis10.0LDLR, APOB
24prion disease10.0APOE, APOB
25lipodystrophy10.0LDLR, APOB
26fatty liver disease10.0APOB, LCAT
27nicotine dependence, protection against10.0APOB, LDLR
28hepatoblastoma9.9APOB, LDLR
29uremia9.9LDLR, LCAT, ALB
30hypothyroidism9.9LDLR, APOB
31norum disease9.9LCAT, APOB, APOE
32abetalipoproteinemia9.9LCAT, APOE, APOB
33liver cirrhosis9.9LCAT, ALB
34tangier disease9.9APOE, APOB, LCAT
35coronary artery disease9.9APOB, LDLR
36kidney disease9.9APOB, LCAT, APOE
37microvascular complications of diabetes 39.8APOE, APOB, ALB
38hypertension, essential9.8APOB, ALB, APOE
39hypercholesterolemia, due to ligand-defective apo b9.8APOB, APOE, LDLR
40hyperlipidemia type 39.8APOE, APOB, LDLR
41xanthomatosis9.8LDLR, APOB, APOE
42acute myocardial infarction9.8APOB, LCAT
43congenital heart disease9.8APOB, LDLR
44cerebrovascular disease9.8APOE, APOB, LDLR
45proteinuria9.8APOB, LCAT, ALB
46diabetes mellitus, insulin-dependent9.8ALB, APOB, LCAT
47hyperalphalipoproteinemia9.8LCAT, APOB, LDLR
48hypoalphalipoproteinemia9.8APOB, LDLR, LCAT
49chronic kidney failure9.8LCAT, APOB, ALB
50stroke, ischemic9.8APOB, LDLR, APOE

Graphical network of the top 20 diseases related to Lipoprotein Glomerulopathy:



Diseases related to lipoprotein glomerulopathy

Symptoms for Lipoprotein Glomerulopathy

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Clinical features from OMIM:

611771

HPO human phenotypes related to Lipoprotein Glomerulopathy:

id Description Frequency HPO Source Accession
1 renal insufficiency HP:0000083
2 proteinuria HP:0000093
3 mesangial abnormality HP:0001966
4 glomerulopathy HP:0100820

Drugs & Therapeutics for Lipoprotein Glomerulopathy

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Drug clinical trials:

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Search NIH Clinical Center for Lipoprotein Glomerulopathy

Genetic Tests for Lipoprotein Glomerulopathy

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Genetic tests related to Lipoprotein Glomerulopathy:

id Genetic test Affiliating Genes
1 Lipoprotein Glomerulopathy22

Anatomical Context for Lipoprotein Glomerulopathy

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MalaCards organs/tissues related to Lipoprotein Glomerulopathy:

31
Kidney, Endothelial

Animal Models for Lipoprotein Glomerulopathy or affiliated genes

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MGI Mouse Phenotypes related to Lipoprotein Glomerulopathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0ALB, LCAT, APOE
2MP:00011868.6APOE, APOB, LDLR
3MP:00053798.3ALB, LCAT, LDLR, APOE
4MP:00053918.2APOE, APOB, LDLR, LCAT
5MP:00053857.8APOE, APOB, LDLR, LCAT
6MP:00053707.7ALB, LCAT, LDLR, APOB, APOE
7MP:00053767.6ALB, LCAT, LDLR, APOB, APOE

Publications for Lipoprotein Glomerulopathy

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Articles related to Lipoprotein Glomerulopathy:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Lipoprotein glomerulopathy: a case report of a rare disease in a Brazilian child. (24676620)
2014
2
Apolipoprotein e mutation and double filtration plasmapheresis therapy on a new chinese patient with lipoprotein glomerulopathy. (25300642)
2014
3
Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice. (25183802)
2014
4
Hereditary features, treatment, and prognosis of the lipoprotein glomerulopathy in patients with the APOE Kyoto mutation. (24025644)
2013
5
Lipoprotein glomerulopathy associated with a mutation in apolipoprotein e. (24348079)
2013
6
A case of lipoprotein glomerulopathy with thrombotic microangiopathy due to malignant hypertension. (23448537)
2013
7
Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy. (23110818)
2013
8
A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy. (24149834)
2013
9
Scavenger receptor expressions in the kidneys of mice with lipoprotein glomerulopathy. (22072188)
2012
10
Identification of a mutation in exon 4 of apolipoprotein E gene in a family affected with lipoprotein glomerulopathy]. (22487820)
2012
11
Macrophage impairment produced by Fc receptor gamma deficiency plays a principal role in the development of lipoprotein glomerulopathy in concert with apoE abnormalities. (22863838)
2012
12
A rare cause of childhood-onset nephrotic syndrome: lipoprotein glomerulopathy. (22874113)
2012
13
A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy. (21325775)
2011
14
Significance of a novel apolipoprotein E variant, ApoE Osaka/Kurashiki, in lipoprotein glomerulopathy. (21670560)
2011
15
Lipoprotein glomerulopathy: first report of 2 not consanguineous Italian men from the same town. (21534236)
2011
16
A novel mutation ApoE2 Kurashiki (R158P) in a patient with lipoprotein glomerulopathy. (21467726)
2011
17
Lipoprotein glomerulopathy. (21464714)
2011
18
A new apolipoprotein E mutation, apoE Las Vegas, in a European-American with lipoprotein glomerulopathy. (20624773)
2010
19
A rare case of lipoprotein glomerulopathy in a white man: an emerging entity in Asia, rare in the white population. (20121619)
2010
20
Lipoprotein glomerulopathy induced by ApoE-Sendai is different from glomerular lesions in aged apoE-deficient mice. (19459027)
2009
21
A rare cause of nephrotic syndrome: lipoprotein glomerulopathy. (19197098)
2009
22
A novel apolipoprotein E mutation, ApoE Tsukuba (Arg 114 Cys), in lipoprotein glomerulopathy. (17967799)
2008
23
Renal failure with intracapillary thrombi. Lipoprotein glomerulopathy. (18414445)
2008
24
Identification of apolipoprotein E Guangzhou (arginine 150 proline), a new variant associated with lipoprotein glomerulopathy. (18046082)
2008
25
A complete genomic analysis of the apolipoprotein E gene in Chinese patients with lipoprotein glomerulopathy. (17918142)
2007
26
Lipoprotein glomerulopathy-like disease in a patient with type III hyperlipoproteinemia due to apolipoprotein E2 (Arg158 Cys)/3 heterozygosity. (17593519)
2007
27
APOE Kyoto mutation in European Americans with lipoprotein glomerulopathy. (18077821)
2007
28
Lipoprotein glomerulopathy: a new apolipoprotein E mutation with enhanced glomerular binding. (16490634)
2006
29
Clinical and pathological analyses of lipoprotein glomerulopathy]. (15181857)
2004
30
Disappearance of intraglomerular lipoprotein thrombi and marked improvement of nephrotic syndrome by bezafibrate treatment in a patient with lipoprotein glomerulopathy. (12921981)
2003
31
A patient with apolipoprotein E2 variant (Q187E) without lipoprotein glomerulopathy. (11877595)
2002
32
Etiological significance of apolipoprotein E mutations in lipoprotein glomerulopathy. (11852253)
2002
33
Interaction of endothelial cells and triglyceride-rich lipoproteins with apolipoprotein E (Arg-->Cys) from a patient with lipoprotein glomerulopathy. (11833049)
2002
34
Chronic graft-versus-host autoimmune disease in Fc receptor gamma chain-deficient mice results in lipoprotein glomerulopathy. (12039982)
2002
35
Diminished LDL receptor and high heparin binding of apolipoprotein E2 Sendai associated with lipoprotein glomerulopathy. (11181800)
2001
36
A new variant of apolipoprotein E (apo E Maebashi) in lipoprotein glomerulopathy. (10684367)
2000
37
Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice. (10903326)
2000
38
Apolipoprotein E2/E5 variants in lipoprotein glomerulopathy recurred in transplanted kidney. (10405216)
1999
39
A novel apolipoprotein E mutation, E2 (Arg25Cys), in lipoprotein glomerulopathy. (10432380)
1999
40
A novel 18-amino acid deletion in apolipoprotein E associated with lipoprotein glomerulopathy. (10504484)
1999
41
Lipoprotein glomerulopathy: significance of lipoprotein and ultrastructural features. (10412734)
1999
42
Association of apolipoprotein E polymorphism with lipoprotein glomerulopathy. Report of 2 cases with a new genotype and comparison of the relative frequencies of apolipoprotein E isoforms in lipoprotein glomerulopathy and in the general population. (9546684)
1998
43
Lipoprotein glomerulopathy and its pathogenesis. (9257045)
1997
44
Lipoprotein glomerulopathy: a pediatric case report. (9090668)
1997
45
A case of lipoprotein glomerulopathy successfully treated with probucol. (8052351)
1994
46
Lipoprotein glomerulopathy. Report of a normolipidemic case and review of the literature. (8322843)
1993
47
Abnormal lipoprotein and apolipoprotein pattern in lipoprotein glomerulopathy. (1951334)
1991
48
A case of lipoprotein glomerulopathy. Light and electron microscopic observations of the glomerulus. (2392939)
1990
49
Lipoprotein glomerulopathy: glomerular lipoprotein thrombi in a patient with hyperlipoproteinemia. (2644825)
1989
50
Similarities between glomerular sclerosis and atherosclerosis in human renal biopsy specimens: a role for lipoprotein glomerulopathy. (2486545)
1989

Variations for Lipoprotein Glomerulopathy

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UniProtKB/Swiss-Prot genetic disease variations for Lipoprotein Glomerulopathy:

62
id Symbol AA change Variation ID SNP ID
1APOEp.Arg43CysVAR_042734
2APOEp.Arg163ProVAR_042735

Clinvar genetic disease variations for Lipoprotein Glomerulopathy:

6
id Gene Variation Type Significance SNP ID Assembly Location
1APOENM_000041.2(APOE): c.488G> C (p.Arg163Pro)single nucleotide variantPathogenicrs121918397GRCh37Chr 19, 45412041: 45412041
2APOENM_000041.2(APOE): c.127C> T (p.Arg43Cys)single nucleotide variantPathogenicrs121918399GRCh37Chr 19, 45411100: 45411100

Expression for genes affiliated with Lipoprotein Glomerulopathy

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Search GEO for disease gene expression data for Lipoprotein Glomerulopathy.

Pathways for genes affiliated with Lipoprotein Glomerulopathy

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Compounds for genes affiliated with Lipoprotein Glomerulopathy

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Compounds related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1tween 80439.6APOE, ALB
2sitosterol439.3APOB, APOE
3dimyristoylphosphatidylcholine439.3LCAT, LDLR, APOE
4campesterol43 2410.2APOE, APOB
5sodium dodecylsulfate439.2ALB, APOE, LCAT
6fructosamine43 2410.1APOB, ALB
7retinyl palmitate43 2410.1LCAT, APOB, APOE
8intralipid439.1APOE, LCAT, APOB
9cholestyramine439.0APOE, LDLR, APOB
10warfarin43 49 24 1212.0ALB, APOB, APOE
11lathosterol43 2410.0APOB, LDLR, APOE
12vitamin b12439.0APOB, ALB, APOE
13xbai439.0LDLR, APOB, APOE
14psyllium438.9LCAT, APOB, LDLR
154-hydroxynonenal43 249.9LCAT, APOB, APOE
16gemfibrozil28 43 1210.9APOB, APOE, LDLR
17lomitapide49 129.9LDLR, APOB
18fenofibrate43 49 1210.9APOE, APOB, LDLR
19fluvastatin43 49 28 1211.9APOE, APOB, LDLR
20homocysteine43 249.9APOE, ALB, APOB
21rosiglitazone28 43 49 24 1212.9APOB, ALB, APOE
22dextran sulfate438.8APOB, ALB, LDLR
23lovastatin43 49 59 28 1212.8LDLR, APOE, APOB
24oleic acid43 28 24 1211.8APOB, ALB, LDLR
25ascorbic acid43 249.7ALB, APOE, LDLR, LCAT
26adenine43 24 1210.6APOE, LDLR, APOB
27probucol43 129.5LCAT, APOE, APOB, LDLR
28cholesterol ester438.5APOE, LDLR, APOB, LCAT
29rosuvastatin43 49 28 1211.5APOE, APOB, LDLR, ALB
30bezafibrate43 28 1210.5APOE, LDLR, LCAT, APOB
31triacylglycerol438.5LDLR, APOB, LCAT, APOE
32pravastatin43 49 28 24 1212.5LCAT, APOE, LDLR, APOB
33atorvastatin43 49 28 24 1212.5LDLR, LCAT, APOB, APOE
34simvastatin43 49 59 28 24 1213.5LDLR, APOB, APOE, LCAT
35thyroxine43 249.5APOE, ALB, LDLR, APOB
36sterol438.4APOB, APOE, LCAT, LDLR
37folate438.4APOE, APOB, LDLR, ALB
38phosphatidylcholine438.4APOE, APOB, LDLR, LCAT
39phospholipid438.4APOB, LCAT, LDLR, APOE
40glutamine438.4LCAT, LDLR, APOE, APOB
41fatty acid438.3LDLR, ALB, LCAT, APOB
42alpha tocopherol438.0LDLR, APOE, APOB, ALB, LCAT
43palmitate438.0APOE, LCAT, LDLR, APOB, ALB
44vitamin a43 24 1210.0APOE, APOB, LDLR, LCAT, ALB
45heparin43 28 24 1211.0ALB, APOE, APOB, LDLR, LCAT
46testosterone43 59 24 1210.9LCAT, ALB, APOE, APOB, LDLR
47cholesterol43 28 24 1210.9ALB, LCAT, LDLR, APOB, APOE
48alanine437.9ALB, APOE, LCAT, LDLR, APOB
49lipid437.9APOB, APOE, ALB, LCAT, LDLR
50glutamate437.8LCAT, LDLR, APOB, APOE

GO Terms for genes affiliated with Lipoprotein Glomerulopathy

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Cellular components related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particleGO:00343649.6LCAT, APOE
2intermediate-density lipoprotein particleGO:00343639.5APOB, APOE
3chylomicronGO:00426279.4APOE, APOB
4endocytic vesicle lumenGO:00716829.4APOB, APOE
5late endosomeGO:00057709.4APOE, LDLR
6very-low-density lipoprotein particleGO:00343619.4APOE, APOB
7blood microparticleGO:00725629.2ALB, APOE
8clathrin-coated endocytic vesicle membraneGO:00306699.1LDLR, APOB
9endosome membraneGO:00100089.0LDLR, APOB
10low-density lipoprotein particleGO:00343628.9LDLR, APOB, APOE
11early endosomeGO:00057698.8LDLR, APOB, APOE
12Golgi apparatusGO:00057948.5LDLR, APOB, APOE
13extracellular spaceGO:00056158.4ALB, LCAT, APOB, APOE
14extracellular regionGO:00055768.2APOE, APOB, LCAT, ALB

Biological processes related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle remodelingGO:00343729.6LCAT, APOE
2high-density lipoprotein particle remodelingGO:00343759.5LCAT, APOE
3reverse cholesterol transportGO:00436919.4APOE, LCAT
4low-density lipoprotein particle remodelingGO:00343749.3APOB, APOE
5artery morphogenesisGO:00488449.2APOB, APOE
6low-density lipoprotein particle clearanceGO:00343839.1APOB, LDLR
7lipoprotein biosynthetic processGO:00421589.0APOE, APOB, LCAT
8cholesterol effluxGO:00333448.9APOB, APOE
9lipoprotein catabolic processGO:00421598.9APOE, APOB, LDLR
10retinoid metabolic processGO:00015238.8LDLR, APOB, APOE
11receptor-mediated endocytosisGO:00068988.8LDLR, APOB, APOE
12cholesterol transportGO:00303018.8APOB, LDLR, LCAT
13phototransduction, visible lightGO:00076038.8APOE, APOB, LDLR
14cholesterol homeostasisGO:00426328.3LCAT, LDLR, APOB, APOE
15cholesterol metabolic processGO:00082038.3LCAT, LDLR, APOB, APOE
16lipoprotein metabolic processGO:00421577.8ALB, LCAT, LDLR, APOB, APOE
17small molecule metabolic processGO:00442817.8APOE, APOB, LDLR, LCAT, ALB

Molecular functions related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antioxidant activityGO:00162099.5ALB, APOE
2cholesterol transporter activityGO:00171279.3APOB, APOE
3low-density lipoprotein particle receptor bindingGO:00507509.3APOB, APOE
4heparin bindingGO:00082019.2APOB, APOE
5phospholipid bindingGO:00055439.1APOE, APOB
6protein bindingGO:00055157.2ALB, LCAT, LDLR, APOB, APOE

Products for genes affiliated with Lipoprotein Glomerulopathy

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Sources for Lipoprotein Glomerulopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet