LPG
MCID: LPP002
MIFTS: 47

Lipoprotein Glomerulopathy (LPG) malady

Genetic diseases, Nephrological diseases, Endocrine diseases, Rare diseases categories
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Summaries for Lipoprotein Glomerulopathy

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47OMIM, 33MalaCards
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MalaCards: Lipoprotein Glomerulopathy, also known as LPG, is related to nephrotic syndrome and atherosclerosis. An important gene associated with Lipoprotein Glomerulopathy is APOE (apolipoprotein E), and among its related pathways are A-beta Uptake and Degradation and Selected targets of C EBPalpha. The compounds tween 80 and sitosterol have been mentioned in the context of this disorder. Affiliated tissues include kidney and endothelial, and related mouse phenotypes are renal/urinary system and pigmentation.

Description from OMIM:47 611771

Aliases & Classifications for Lipoprotein Glomerulopathy

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47OMIM, 49Orphanet, 62UMLS
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Classifications:



Characteristics (Orphanet epidemiological data):

49
lipoprotein glomerulopathy:
Inheritance: Autosomal dominant; Age of onset: Variable


Aliases & Descriptions:

lipoprotein glomerulopathy 47 49 62
lpg 49


External Ids:

OMIM47 611771

Related Diseases for Lipoprotein Glomerulopathy

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17GeneCards, 18GeneDecks
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Diseases related to Lipoprotein Glomerulopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1nephrotic syndrome30.7ALB, LCAT, APOB, APOE
2atherosclerosis30.2APOE, APOB, LDLR, LCAT, ALB
3hypertension30.1ALB, APOB, APOE
4gamma chain deficiency10.1
5malignant hypertension10.1
6psoriasis10.1
7endotheliitis10.1
8hyperhomocysteinemia10.0ALB, APOE
9amyloidosis10.0ALB, APOE
10alcoholic liver cirrhosis10.0LCAT, ALB
11aortic disease10.0APOE, LDLR
12glomerulosclerosis10.0LCAT, ALB
13cholestasis10.0LCAT, ALB
14familial combined hyperlipidemia10.0APOB, APOE
15age related macular degeneration10.0APOB, APOE
16familial hypertriglyceridemia10.0APOB, APOE
17arcus senilis10.0APOB, LCAT
18galactosemia10.0ALB, LCAT
19peripheral vascular disease10.0APOB, ALB
20familial hypercholesterolemia10.0LDLR, APOB
21primary hyperoxaluria10.0ALB, LCAT
22arteriosclerosis10.0LDLR, APOB
23prion disease10.0APOB, APOE
24fatty liver disease10.0LCAT, APOB
25lipodystrophy10.0APOB, LDLR
26hepatoblastoma10.0APOB, LDLR
27uremia10.0LDLR, LCAT, ALB
28hypothyroidism10.0APOB, LDLR
29norum disease10.0LCAT, APOB, APOE
30abetalipoproteinemia10.0APOE, APOB, LCAT
31liver cirrhosis10.0ALB, LCAT
32tangier disease10.0LCAT, APOB, APOE
33stroke, ischemic10.0ALB, APOB, APOE
34coronary artery disease10.0LDLR, APOB
35diabetic nephropathy10.0ALB, APOB, APOE
36xanthomatosis10.0APOE, APOB, LDLR
37hyperlipidemia type 310.0APOE, APOB, LDLR
38acute myocardial infarction10.0LCAT, APOB
39congenital heart disease10.0APOB, LDLR
40essential hypertension10.0APOB, LCAT, ALB
41proteinuria10.0ALB, LCAT, APOB
42type 1 diabetes mellitus10.0APOB, LCAT, ALB
43hyperalphalipoproteinemia10.0APOB, LDLR, LCAT
44hypoalphalipoproteinemia10.0APOB, LDLR, LCAT
45chronic kidney failure10.0ALB, LCAT, APOB
46hyperinsulinism9.9LCAT, LDLR, APOB
47cerebrovascular disease9.9LDLR, APOB, APOE
48metabolic syndrome x9.9LCAT, LDLR, APOB
49alzheimer's disease9.9APOE, APOB, LDLR
50diabetes mellitus9.9APOE, APOB, LCAT, ALB

Graphical network of the top 20 diseases related to Lipoprotein Glomerulopathy:



Diseases related to lipoprotein glomerulopathy

Symptoms for Lipoprotein Glomerulopathy

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47OMIM
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Clinical features from OMIM:

611771

Drugs & Therapeutics for Lipoprotein Glomerulopathy

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Lipoprotein Glomerulopathy

Search NIH Clinical Center for Lipoprotein Glomerulopathy

Genetic Tests for Lipoprotein Glomerulopathy

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Anatomical Context for Lipoprotein Glomerulopathy

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33MalaCards
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MalaCards organs/tissues related to Lipoprotein Glomerulopathy:

33
Kidney, Endothelial

Animal Models for Lipoprotein Glomerulopathy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Lipoprotein Glomerulopathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0ALB, LCAT, APOE
2MP:00011868.6APOE, APOB, LDLR
3MP:00053798.3ALB, LCAT, LDLR, APOE
4MP:00053918.2APOE, APOB, LDLR, LCAT
5MP:00053857.8APOE, APOB, LDLR, LCAT
6MP:00053707.7ALB, LCAT, LDLR, APOB, APOE
7MP:00053767.6ALB, LCAT, LDLR, APOB, APOE

Publications for Lipoprotein Glomerulopathy

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52PubMed
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Articles related to Lipoprotein Glomerulopathy:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Hereditary features, treatment, and prognosis of the lipoprotein glomerulopathy in patients with the APOE Kyoto mutation. (24025644)
2013
2
Lipoprotein glomerulopathy associated with a mutation in apolipoprotein e. (24348079)
2013
3
A case of lipoprotein glomerulopathy with thrombotic microangiopathy due to malignant hypertension. (23448537)
2013
4
Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy. (23110818)
2013
5
A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy. (24149834)
2013
6
Scavenger receptor expressions in the kidneys of mice with lipoprotein glomerulopathy. (22072188)
2012
7
Identification of a mutation in exon 4 of apolipoprotein E gene in a family affected with lipoprotein glomerulopathy]. (22487820)
2012
8
Macrophage impairment produced by Fc receptor gamma deficiency plays a principal role in the development of lipoprotein glomerulopathy in concert with apoE abnormalities. (22863838)
2012
9
A rare cause of childhood-onset nephrotic syndrome: lipoprotein glomerulopathy. (22874113)
2012
10
A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy. (21325775)
2011
11
Significance of a novel apolipoprotein E variant, ApoE Osaka/Kurashiki, in lipoprotein glomerulopathy. (21670560)
2011
12
Lipoprotein glomerulopathy: first report of 2 not consanguineous Italian men from the same town. (21534236)
2011
13
A novel mutation ApoE2 Kurashiki (R158P) in a patient with lipoprotein glomerulopathy. (21467726)
2011
14
Lipoprotein glomerulopathy. (21464714)
2011
15
A new apolipoprotein E mutation, apoE Las Vegas, in a European-American with lipoprotein glomerulopathy. (20624773)
2010
16
A rare case of lipoprotein glomerulopathy in a white man: an emerging entity in Asia, rare in the white population. (20121619)
2010
17
Lipoprotein glomerulopathy induced by ApoE-Sendai is different from glomerular lesions in aged apoE-deficient mice. (19459027)
2009
18
A rare cause of nephrotic syndrome: lipoprotein glomerulopathy. (19197098)
2009
19
A novel apolipoprotein E mutation, ApoE Tsukuba (Arg 114 Cys), in lipoprotein glomerulopathy. (17967799)
2008
20
Renal failure with intracapillary thrombi. Lipoprotein glomerulopathy. (18414445)
2008
21
Identification of apolipoprotein E Guangzhou (arginine 150 proline), a new variant associated with lipoprotein glomerulopathy. (18046082)
2008
22
A complete genomic analysis of the apolipoprotein E gene in Chinese patients with lipoprotein glomerulopathy. (17918142)
2007
23
Lipoprotein glomerulopathy-like disease in a patient with type III hyperlipoproteinemia due to apolipoprotein E2 (Arg158 Cys)/3 heterozygosity. (17593519)
2007
24
APOE Kyoto mutation in European Americans with lipoprotein glomerulopathy. (18077821)
2007
25
Lipoprotein glomerulopathy: a new apolipoprotein E mutation with enhanced glomerular binding. (16490634)
2006
26
Clinical and pathological analyses of lipoprotein glomerulopathy]. (15181857)
2004
27
Disappearance of intraglomerular lipoprotein thrombi and marked improvement of nephrotic syndrome by bezafibrate treatment in a patient with lipoprotein glomerulopathy. (12921981)
2003
28
Resolution of typical lipoprotein glomerulopathy by intensive lipid-lowering therapy. (12500244)
2003
29
Lipoprotein glomerulopathy associated with psoriasis vulgaris: report of 2 cases with apolipoprotein E3/3. (12955707)
2003
30
A patient with apolipoprotein E2 variant (Q187E) without lipoprotein glomerulopathy. (11877595)
2002
31
Etiological significance of apolipoprotein E mutations in lipoprotein glomerulopathy. (11852253)
2002
32
Interaction of endothelial cells and triglyceride-rich lipoproteins with apolipoprotein E (Arg-->Cys) from a patient with lipoprotein glomerulopathy. (11833049)
2002
33
Chronic graft-versus-host autoimmune disease in Fc receptor gamma chain-deficient mice results in lipoprotein glomerulopathy. (12039982)
2002
34
Diminished LDL receptor and high heparin binding of apolipoprotein E2 Sendai associated with lipoprotein glomerulopathy. (11181800)
2001
35
A new variant of apolipoprotein E (apo E Maebashi) in lipoprotein glomerulopathy. (10684367)
2000
36
Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice. (10903326)
2000
37
Apolipoprotein E2/E5 variants in lipoprotein glomerulopathy recurred in transplanted kidney. (10405216)
1999
38
A novel apolipoprotein E mutation, E2 (Arg25Cys), in lipoprotein glomerulopathy. (10432380)
1999
39
A novel 18-amino acid deletion in apolipoprotein E associated with lipoprotein glomerulopathy. (10504484)
1999
40
Lipoprotein glomerulopathy: significance of lipoprotein and ultrastructural features. (10412734)
1999
41
Lipoprotein glomerulopathy: a new cause of nephrotic syndrome after renal transplantation. Implications for renal transplantation. (10052520)
1999
42
Association of apolipoprotein E polymorphism with lipoprotein glomerulopathy. Report of 2 cases with a new genotype and comparison of the relative frequencies of apolipoprotein E isoforms in lipoprotein glomerulopathy and in the general population. (9546684)
1998
43
Lipoprotein glomerulopathy and its pathogenesis. (9257045)
1997
44
Lipoprotein glomerulopathy: a pediatric case report. (9090668)
1997
45
A case of lipoprotein glomerulopathy successfully treated with probucol. (8052351)
1994
46
Lipoprotein glomerulopathy. Report of a normolipidemic case and review of the literature. (8322843)
1993
47
Abnormal lipoprotein and apolipoprotein pattern in lipoprotein glomerulopathy. (1951334)
1991
48
Long-term follow-up of a paediatric case of lipoprotein glomerulopathy. (2397177)
1990
49
Lipoprotein glomerulopathy: glomerular lipoprotein thrombi in a patient with hyperlipoproteinemia. (2644825)
1989
50
Similarities between glomerular sclerosis and atherosclerosis in human renal biopsy specimens: a role for lipoprotein glomerulopathy. (2486545)
1989

Variations for Lipoprotein Glomerulopathy

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64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Lipoprotein Glomerulopathy:

64
id Symbol AA change Variation ID SNP ID
1APOEp.Arg43CysVAR_042734
2APOEp.Arg163ProVAR_042735

Clinvar genetic disease variations for Lipoprotein Glomerulopathy:

1
id Gene Name Type Significance SNP ID Assembly Location
1APOENM_000041.2(APOE): c.488G> C (p.Arg163Pro)single nucleotide variantPathogenicrs121918397GRCh37Chr 19, 45412041: 45412041
2APOENM_000041.2(APOE): c.127C> T (p.Arg43Cys)single nucleotide variantPathogenicrs121918399GRCh37Chr 19, 45411100: 45411100

Expression for genes affiliated with Lipoprotein Glomerulopathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipoprotein Glomerulopathy

Search GEO for disease gene expression data for Lipoprotein Glomerulopathy.

Pathways for genes affiliated with Lipoprotein Glomerulopathy

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50PathCards, 54R&D Systems, 12EMD Millipore, 55Reactome, 38NCBI BioSystems Database, 51PharmGKB, 30KEGG
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Compounds for genes affiliated with Lipoprotein Glomerulopathy

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45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1tween 80459.6APOE, ALB
2sitosterol459.3APOB, APOE
3dimyristoylphosphatidylcholine459.3LCAT, LDLR, APOE
4campesterol45 2410.2APOE, APOB
5sodium dodecylsulfate459.2ALB, APOE, LCAT
6fructosamine45 2410.1APOB, ALB
7retinyl palmitate45 2410.1LCAT, APOB, APOE
8intralipid459.1APOE, LCAT, APOB
9cholestyramine459.0APOE, LDLR, APOB
10warfarin45 51 24 1112.0ALB, APOB, APOE
11lathosterol45 2410.0APOB, LDLR, APOE
12vitamin b12459.0APOB, ALB, APOE
13xbai459.0LDLR, APOB, APOE
14psyllium458.9LCAT, APOB, LDLR
154-hydroxynonenal45 249.9LCAT, APOB, APOE
16gemfibrozil29 45 1110.9APOB, APOE, LDLR
17lomitapide51 119.9LDLR, APOB
18fenofibrate45 51 1110.9APOE, APOB, LDLR
19fluvastatin45 51 29 1111.9APOE, APOB, LDLR
20homocysteine45 249.9APOE, ALB, APOB
21rosiglitazone29 45 51 24 1112.9APOB, ALB, APOE
22dextran sulfate458.8APOB, ALB, LDLR
23lovastatin45 51 61 29 1112.8LDLR, APOE, APOB
24oleic acid45 29 24 1111.8APOB, ALB, LDLR
25ascorbic acid45 249.7ALB, APOE, LDLR, LCAT
26adenine45 24 1110.6APOE, LDLR, APOB
27probucol45 119.5LCAT, APOE, APOB, LDLR
28cholesterol ester458.5APOE, LDLR, APOB, LCAT
29rosuvastatin45 51 29 1111.5APOE, APOB, LDLR, ALB
30bezafibrate45 29 1110.5APOE, LDLR, LCAT, APOB
31triacylglycerol458.5LDLR, APOB, LCAT, APOE
32pravastatin45 51 29 24 1112.5LCAT, APOE, LDLR, APOB
33atorvastatin45 51 29 24 1112.5LDLR, LCAT, APOB, APOE
34simvastatin45 51 61 29 24 1113.5LDLR, APOB, APOE, LCAT
35thyroxine45 249.5APOE, ALB, LDLR, APOB
36sterol458.4APOB, APOE, LCAT, LDLR
37folate458.4APOE, APOB, LDLR, ALB
38phosphatidylcholine458.4APOE, APOB, LDLR, LCAT
39phospholipid458.4APOB, LCAT, LDLR, APOE
40glutamine458.4LCAT, LDLR, APOE, APOB
41fatty acid458.3LDLR, ALB, LCAT, APOB
42alpha tocopherol458.0LDLR, APOE, APOB, ALB, LCAT
43palmitate458.0APOE, LCAT, LDLR, APOB, ALB
44vitamin a45 24 1110.0APOE, APOB, LDLR, LCAT, ALB
45heparin45 29 24 1111.0ALB, APOE, APOB, LDLR, LCAT
46testosterone45 61 24 1110.9LCAT, ALB, APOE, APOB, LDLR
47cholesterol45 29 24 1110.9ALB, LCAT, LDLR, APOB, APOE
48alanine457.9ALB, APOE, LCAT, LDLR, APOB
49lipid457.9APOB, APOE, ALB, LCAT, LDLR
50glutamate457.8LCAT, LDLR, APOB, APOE

GO Terms for genes affiliated with Lipoprotein Glomerulopathy

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16Gene Ontology
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Cellular components related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particleGO:0343649.6LCAT, APOE
2intermediate-density lipoprotein particleGO:0343639.5APOB, APOE
3chylomicronGO:0426279.4APOE, APOB
4endocytic vesicle lumenGO:0716829.4APOB, APOE
5late endosomeGO:0057709.4APOE, LDLR
6very-low-density lipoprotein particleGO:0343619.4APOE, APOB
7blood microparticleGO:0725629.2ALB, APOE
8clathrin-coated endocytic vesicle membraneGO:0306699.1LDLR, APOB
9endosome membraneGO:0100089.0LDLR, APOB
10low-density lipoprotein particleGO:0343628.9LDLR, APOB, APOE
11early endosomeGO:0057698.8LDLR, APOB, APOE
12Golgi apparatusGO:0057948.5LDLR, APOB, APOE
13extracellular spaceGO:0056158.4ALB, LCAT, APOB, APOE
14extracellular regionGO:0055768.2APOE, APOB, LCAT, ALB

Biological processes related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle remodelingGO:0343729.6LCAT, APOE
2high-density lipoprotein particle remodelingGO:0343759.5LCAT, APOE
3reverse cholesterol transportGO:0436919.4APOE, LCAT
4low-density lipoprotein particle remodelingGO:0343749.3APOB, APOE
5artery morphogenesisGO:0488449.2APOB, APOE
6low-density lipoprotein particle clearanceGO:0343839.1APOB, LDLR
7lipoprotein biosynthetic processGO:0421589.0APOE, APOB, LCAT
8cholesterol effluxGO:0333448.9APOB, APOE
9lipoprotein catabolic processGO:0421598.9APOE, APOB, LDLR
10retinoid metabolic processGO:0015238.8LDLR, APOB, APOE
11receptor-mediated endocytosisGO:0068988.8LDLR, APOB, APOE
12cholesterol transportGO:0303018.8APOB, LDLR, LCAT
13phototransduction, visible lightGO:0076038.8APOE, APOB, LDLR
14cholesterol homeostasisGO:0426328.3LCAT, LDLR, APOB, APOE
15cholesterol metabolic processGO:0082038.3LCAT, LDLR, APOB, APOE
16lipoprotein metabolic processGO:0421577.8ALB, LCAT, LDLR, APOB, APOE
17small molecule metabolic processGO:0442817.8APOE, APOB, LDLR, LCAT, ALB

Molecular functions related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antioxidant activityGO:0162099.5ALB, APOE
2cholesterol transporter activityGO:0171279.3APOB, APOE
3low-density lipoprotein particle receptor bindingGO:0507509.3APOB, APOE
4heparin bindingGO:0082019.2APOB, APOE
5phospholipid bindingGO:0055439.1APOE, APOB
6protein bindingGO:0055157.2ALB, LCAT, LDLR, APOB, APOE

Products for genes affiliated with Lipoprotein Glomerulopathy

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Sources for Lipoprotein Glomerulopathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet