LPG
MCID: LPP002
MIFTS: 48

Lipoprotein Glomerulopathy (LPG) malady

Genetic diseases, Nephrological diseases, Metabolic diseases, Endocrine diseases, Rare diseases categories
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Summaries for Lipoprotein Glomerulopathy

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MalaCards based summary: Lipoprotein Glomerulopathy, also known as LPG, is related to nephrotic syndrome and hypertension, and has symptoms including An important gene associated with Lipoprotein Glomerulopathy is APOE (apolipoprotein E), and among its related pathways are A-beta Uptake and Degradation and Selected targets of HNF1. The compounds tween 80 and sitosterol have been mentioned in the context of this disorder. Affiliated tissues include kidney and endothelial, and related mouse phenotypes are renal/urinary system and pigmentation.

Description from OMIM:46 611771

Aliases & Classifications for Lipoprotein Glomerulopathy

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Lipoprotein Glomerulopathy, Aliases & Descriptions:

Name: Lipoprotein Glomerulopathy 46 48 62
 
Lpg 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
lipoprotein glomerulopathy:
Inheritance: Autosomal dominant; Age of onset: Variable


External Ids:

OMIM46 611771

Related Diseases for Lipoprotein Glomerulopathy

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Diseases related to Lipoprotein Glomerulopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1nephrotic syndrome30.3ALB, LCAT, APOB, APOE
2hypertension30.0ALB, APOB, APOE
3atherosclerosis29.6APOE, APOB, LDLR, LCAT, ALB
4hyperhomocysteinemia10.2ALB, APOE
5amyloidosis10.2ALB, APOE
6alcoholic liver cirrhosis10.2LCAT, ALB
7aortic disease10.1APOE, LDLR
8glomerulosclerosis10.1LCAT, ALB
9gamma chain deficiency10.1
10malignant hypertension10.1
11psoriasis10.1
12endotheliitis10.1
13cholestasis10.1LCAT, ALB
14familial combined hyperlipidemia10.1APOB, APOE
15age related macular degeneration10.1APOB, APOE
16familial hypertriglyceridemia10.1APOB, APOE
17arcus senilis10.1APOB, LCAT
18galactosemia10.1ALB, LCAT
19peripheral vascular disease10.0APOB, ALB
20familial hypercholesterolemia10.0LDLR, APOB
21primary hyperoxaluria10.0ALB, LCAT
22arteriosclerosis10.0LDLR, APOB
23prion disease10.0APOB, APOE
24fatty liver disease10.0LCAT, APOB
25lipodystrophy10.0APOB, LDLR
26hepatoblastoma9.9APOB, LDLR
27uremia9.9LDLR, LCAT, ALB
28hypothyroidism9.9APOB, LDLR
29norum disease9.9LCAT, APOB, APOE
30abetalipoproteinemia9.9APOE, APOB, LCAT
31liver cirrhosis9.9ALB, LCAT
32tangier disease9.9LCAT, APOB, APOE
33stroke, ischemic9.9ALB, APOB, APOE
34coronary artery anomaly9.9LDLR, APOB
35diabetic nephropathy9.9ALB, APOB, APOE
36xanthomatosis9.8APOE, APOB, LDLR
37hyperlipidemia type 39.8APOE, APOB, LDLR
38acute myocardial infarction9.8LCAT, APOB
39congenital heart disease9.8APOB, LDLR
40essential hypertension9.8APOB, LCAT, ALB
41proteinuria9.8ALB, LCAT, APOB
42type 1 diabetes mellitus9.8APOB, LCAT, ALB
43hyperalphalipoproteinemia9.8APOB, LDLR, LCAT
44hypoalphalipoproteinemia9.8APOB, LDLR, LCAT
45chronic kidney failure9.8ALB, LCAT, APOB
46hyperinsulinism9.8LCAT, LDLR, APOB
47cerebrovascular disease9.8LDLR, APOB, APOE
48metabolic syndrome x9.8LCAT, LDLR, APOB
49alzheimer's disease9.7APOE, APOB, LDLR
50diabetes mellitus9.6APOE, APOB, LCAT, ALB

Graphical network of the top 20 diseases related to Lipoprotein Glomerulopathy:



Diseases related to lipoprotein glomerulopathy

Symptoms for Lipoprotein Glomerulopathy

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Clinical features from OMIM:

611771

HPO human phenotypes related to Lipoprotein Glomerulopathy:

id Description Frequency HPO Source Accession
1 renal insufficiency HP:0000083
2 proteinuria HP:0000093
3 mesangial abnormality HP:0001966
4 glomerulopathy HP:0100820

Drugs & Therapeutics for Lipoprotein Glomerulopathy

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Drug clinical trials:

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Search NIH Clinical Center for Lipoprotein Glomerulopathy

Genetic Tests for Lipoprotein Glomerulopathy

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Anatomical Context for Lipoprotein Glomerulopathy

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MalaCards organs/tissues related to Lipoprotein Glomerulopathy:

32
Kidney, Endothelial

Animal Models for Lipoprotein Glomerulopathy or affiliated genes

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MGI Mouse Phenotypes related to Lipoprotein Glomerulopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0ALB, LCAT, APOE
2MP:00011868.6APOE, APOB, LDLR
3MP:00053798.3ALB, LCAT, LDLR, APOE
4MP:00053918.2APOE, APOB, LDLR, LCAT
5MP:00053857.8APOE, APOB, LDLR, LCAT
6MP:00053707.7ALB, LCAT, LDLR, APOB, APOE
7MP:00053767.6ALB, LCAT, LDLR, APOB, APOE

Publications for Lipoprotein Glomerulopathy

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Articles related to Lipoprotein Glomerulopathy:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Lipoprotein glomerulopathy: a case report of a rare disease in a Brazilian child. (24676620)
2014
2
Apolipoprotein e mutation and double filtration plasmapheresis therapy on a new chinese patient with lipoprotein glomerulopathy. (25300642)
2014
3
Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice. (25183802)
2014
4
Hereditary features, treatment, and prognosis of the lipoprotein glomerulopathy in patients with the APOE Kyoto mutation. (24025644)
2013
5
Lipoprotein glomerulopathy associated with a mutation in apolipoprotein e. (24348079)
2013
6
A case of lipoprotein glomerulopathy with thrombotic microangiopathy due to malignant hypertension. (23448537)
2013
7
Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy. (23110818)
2013
8
A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy. (24149834)
2013
9
Scavenger receptor expressions in the kidneys of mice with lipoprotein glomerulopathy. (22072188)
2012
10
Identification of a mutation in exon 4 of apolipoprotein E gene in a family affected with lipoprotein glomerulopathy]. (22487820)
2012
11
Macrophage impairment produced by Fc receptor gamma deficiency plays a principal role in the development of lipoprotein glomerulopathy in concert with apoE abnormalities. (22863838)
2012
12
A rare cause of childhood-onset nephrotic syndrome: lipoprotein glomerulopathy. (22874113)
2012
13
A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy. (21325775)
2011
14
Significance of a novel apolipoprotein E variant, ApoE Osaka/Kurashiki, in lipoprotein glomerulopathy. (21670560)
2011
15
Lipoprotein glomerulopathy: first report of 2 not consanguineous Italian men from the same town. (21534236)
2011
16
A novel mutation ApoE2 Kurashiki (R158P) in a patient with lipoprotein glomerulopathy. (21467726)
2011
17
Lipoprotein glomerulopathy. (21464714)
2011
18
A new apolipoprotein E mutation, apoE Las Vegas, in a European-American with lipoprotein glomerulopathy. (20624773)
2010
19
A rare case of lipoprotein glomerulopathy in a white man: an emerging entity in Asia, rare in the white population. (20121619)
2010
20
Lipoprotein glomerulopathy induced by ApoE-Sendai is different from glomerular lesions in aged apoE-deficient mice. (19459027)
2009
21
A rare cause of nephrotic syndrome: lipoprotein glomerulopathy. (19197098)
2009
22
A novel apolipoprotein E mutation, ApoE Tsukuba (Arg 114 Cys), in lipoprotein glomerulopathy. (17967799)
2008
23
Renal failure with intracapillary thrombi. Lipoprotein glomerulopathy. (18414445)
2008
24
Identification of apolipoprotein E Guangzhou (arginine 150 proline), a new variant associated with lipoprotein glomerulopathy. (18046082)
2008
25
A complete genomic analysis of the apolipoprotein E gene in Chinese patients with lipoprotein glomerulopathy. (17918142)
2007
26
Lipoprotein glomerulopathy-like disease in a patient with type III hyperlipoproteinemia due to apolipoprotein E2 (Arg158 Cys)/3 heterozygosity. (17593519)
2007
27
APOE Kyoto mutation in European Americans with lipoprotein glomerulopathy. (18077821)
2007
28
Lipoprotein glomerulopathy: a new apolipoprotein E mutation with enhanced glomerular binding. (16490634)
2006
29
Clinical and pathological analyses of lipoprotein glomerulopathy]. (15181857)
2004
30
Disappearance of intraglomerular lipoprotein thrombi and marked improvement of nephrotic syndrome by bezafibrate treatment in a patient with lipoprotein glomerulopathy. (12921981)
2003
31
A patient with apolipoprotein E2 variant (Q187E) without lipoprotein glomerulopathy. (11877595)
2002
32
Etiological significance of apolipoprotein E mutations in lipoprotein glomerulopathy. (11852253)
2002
33
Interaction of endothelial cells and triglyceride-rich lipoproteins with apolipoprotein E (Arg-->Cys) from a patient with lipoprotein glomerulopathy. (11833049)
2002
34
Chronic graft-versus-host autoimmune disease in Fc receptor gamma chain-deficient mice results in lipoprotein glomerulopathy. (12039982)
2002
35
Diminished LDL receptor and high heparin binding of apolipoprotein E2 Sendai associated with lipoprotein glomerulopathy. (11181800)
2001
36
A new variant of apolipoprotein E (apo E Maebashi) in lipoprotein glomerulopathy. (10684367)
2000
37
Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice. (10903326)
2000
38
Apolipoprotein E2/E5 variants in lipoprotein glomerulopathy recurred in transplanted kidney. (10405216)
1999
39
A novel apolipoprotein E mutation, E2 (Arg25Cys), in lipoprotein glomerulopathy. (10432380)
1999
40
A novel 18-amino acid deletion in apolipoprotein E associated with lipoprotein glomerulopathy. (10504484)
1999
41
Lipoprotein glomerulopathy: significance of lipoprotein and ultrastructural features. (10412734)
1999
42
Association of apolipoprotein E polymorphism with lipoprotein glomerulopathy. Report of 2 cases with a new genotype and comparison of the relative frequencies of apolipoprotein E isoforms in lipoprotein glomerulopathy and in the general population. (9546684)
1998
43
Lipoprotein glomerulopathy and its pathogenesis. (9257045)
1997
44
Lipoprotein glomerulopathy: a pediatric case report. (9090668)
1997
45
A case of lipoprotein glomerulopathy successfully treated with probucol. (8052351)
1994
46
Lipoprotein glomerulopathy. Report of a normolipidemic case and review of the literature. (8322843)
1993
47
Abnormal lipoprotein and apolipoprotein pattern in lipoprotein glomerulopathy. (1951334)
1991
48
A case of lipoprotein glomerulopathy. Light and electron microscopic observations of the glomerulus. (2392939)
1990
49
Lipoprotein glomerulopathy: glomerular lipoprotein thrombi in a patient with hyperlipoproteinemia. (2644825)
1989
50
Similarities between glomerular sclerosis and atherosclerosis in human renal biopsy specimens: a role for lipoprotein glomerulopathy. (2486545)
1989

Variations for Lipoprotein Glomerulopathy

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UniProtKB/Swiss-Prot genetic disease variations for Lipoprotein Glomerulopathy:

64
id Symbol AA change Variation ID SNP ID
1APOEp.Arg43CysVAR_042734
2APOEp.Arg163ProVAR_042735

Clinvar genetic disease variations for Lipoprotein Glomerulopathy:

6
id Gene Name Type Significance SNP ID Assembly Location
1APOENM_000041.2(APOE): c.488G> C (p.Arg163Pro)single nucleotide variantPathogenicrs121918397GRCh37Chr 19, 45412041: 45412041
2APOENM_000041.2(APOE): c.127C> T (p.Arg43Cys)single nucleotide variantPathogenicrs121918399GRCh37Chr 19, 45411100: 45411100

Expression for genes affiliated with Lipoprotein Glomerulopathy

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Expression patterns in normal tissues for genes affiliated with Lipoprotein Glomerulopathy

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Pathways for genes affiliated with Lipoprotein Glomerulopathy

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Compounds for genes affiliated with Lipoprotein Glomerulopathy

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Compounds related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1tween 80449.6APOE, ALB
2sitosterol449.3APOB, APOE
3dimyristoylphosphatidylcholine449.3LCAT, LDLR, APOE
4campesterol44 2410.2APOE, APOB
5sodium dodecylsulfate449.2ALB, APOE, LCAT
6fructosamine44 2410.1APOB, ALB
7retinyl palmitate44 2410.1LCAT, APOB, APOE
8intralipid449.1APOE, LCAT, APOB
9cholestyramine449.0APOE, LDLR, APOB
10warfarin44 50 24 1112.0ALB, APOB, APOE
11lathosterol44 2410.0APOB, LDLR, APOE
12vitamin b12449.0APOB, ALB, APOE
13xbai449.0LDLR, APOB, APOE
14psyllium448.9LCAT, APOB, LDLR
154-hydroxynonenal44 249.9LCAT, APOB, APOE
16gemfibrozil28 44 1110.9APOB, APOE, LDLR
17lomitapide50 119.9LDLR, APOB
18fenofibrate44 50 1110.9APOE, APOB, LDLR
19fluvastatin44 50 28 1111.9APOE, APOB, LDLR
20homocysteine44 249.9APOE, ALB, APOB
21rosiglitazone28 44 50 24 1112.9APOB, ALB, APOE
22dextran sulfate448.8APOB, ALB, LDLR
23lovastatin44 50 61 28 1112.8LDLR, APOE, APOB
24oleic acid44 28 24 1111.8APOB, ALB, LDLR
25ascorbic acid44 249.7ALB, APOE, LDLR, LCAT
26adenine44 24 1110.6APOE, LDLR, APOB
27probucol44 119.5LCAT, APOE, APOB, LDLR
28cholesterol ester448.5APOE, LDLR, APOB, LCAT
29rosuvastatin44 50 28 1111.5APOE, APOB, LDLR, ALB
30bezafibrate44 28 1110.5APOE, LDLR, LCAT, APOB
31triacylglycerol448.5LDLR, APOB, LCAT, APOE
32pravastatin44 50 28 24 1112.5LCAT, APOE, LDLR, APOB
33atorvastatin44 50 28 24 1112.5LDLR, LCAT, APOB, APOE
34simvastatin44 50 61 28 24 1113.5LDLR, APOB, APOE, LCAT
35thyroxine44 249.5APOE, ALB, LDLR, APOB
36sterol448.4APOB, APOE, LCAT, LDLR
37folate448.4APOE, APOB, LDLR, ALB
38phosphatidylcholine448.4APOE, APOB, LDLR, LCAT
39phospholipid448.4APOB, LCAT, LDLR, APOE
40glutamine448.4LCAT, LDLR, APOE, APOB
41fatty acid448.3LDLR, ALB, LCAT, APOB
42alpha tocopherol448.0LDLR, APOE, APOB, ALB, LCAT
43palmitate448.0APOE, LCAT, LDLR, APOB, ALB
44vitamin a44 24 1110.0APOE, APOB, LDLR, LCAT, ALB
45heparin44 28 24 1111.0ALB, APOE, APOB, LDLR, LCAT
46testosterone44 61 24 1110.9LCAT, ALB, APOE, APOB, LDLR
47cholesterol44 28 24 1110.9ALB, LCAT, LDLR, APOB, APOE
48alanine447.9ALB, APOE, LCAT, LDLR, APOB
49lipid447.9APOB, APOE, ALB, LCAT, LDLR
50glutamate447.8LCAT, LDLR, APOB, APOE

GO Terms for genes affiliated with Lipoprotein Glomerulopathy

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Cellular components related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particleGO:0343649.6LCAT, APOE
2intermediate-density lipoprotein particleGO:0343639.5APOB, APOE
3chylomicronGO:0426279.4APOE, APOB
4endocytic vesicle lumenGO:0716829.4APOB, APOE
5late endosomeGO:0057709.4APOE, LDLR
6very-low-density lipoprotein particleGO:0343619.4APOE, APOB
7blood microparticleGO:0725629.2ALB, APOE
8clathrin-coated endocytic vesicle membraneGO:0306699.1LDLR, APOB
9endosome membraneGO:0100089.0LDLR, APOB
10low-density lipoprotein particleGO:0343628.9LDLR, APOB, APOE
11early endosomeGO:0057698.8LDLR, APOB, APOE
12Golgi apparatusGO:0057948.5LDLR, APOB, APOE
13extracellular spaceGO:0056158.4ALB, LCAT, APOB, APOE
14extracellular regionGO:0055768.2APOE, APOB, LCAT, ALB

Biological processes related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle remodelingGO:0343729.6LCAT, APOE
2high-density lipoprotein particle remodelingGO:0343759.5LCAT, APOE
3reverse cholesterol transportGO:0436919.4APOE, LCAT
4low-density lipoprotein particle remodelingGO:0343749.3APOB, APOE
5artery morphogenesisGO:0488449.2APOB, APOE
6low-density lipoprotein particle clearanceGO:0343839.1APOB, LDLR
7lipoprotein biosynthetic processGO:0421589.0APOE, APOB, LCAT
8cholesterol effluxGO:0333448.9APOB, APOE
9lipoprotein catabolic processGO:0421598.9APOE, APOB, LDLR
10retinoid metabolic processGO:0015238.8LDLR, APOB, APOE
11receptor-mediated endocytosisGO:0068988.8LDLR, APOB, APOE
12cholesterol transportGO:0303018.8APOB, LDLR, LCAT
13phototransduction, visible lightGO:0076038.8APOE, APOB, LDLR
14cholesterol homeostasisGO:0426328.3LCAT, LDLR, APOB, APOE
15cholesterol metabolic processGO:0082038.3LCAT, LDLR, APOB, APOE
16lipoprotein metabolic processGO:0421577.8ALB, LCAT, LDLR, APOB, APOE
17small molecule metabolic processGO:0442817.8APOE, APOB, LDLR, LCAT, ALB

Molecular functions related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antioxidant activityGO:0162099.5ALB, APOE
2cholesterol transporter activityGO:0171279.3APOB, APOE
3low-density lipoprotein particle receptor bindingGO:0507509.3APOB, APOE
4heparin bindingGO:0082019.2APOB, APOE
5phospholipid bindingGO:0055439.1APOE, APOB
6protein bindingGO:0055157.2ALB, LCAT, LDLR, APOB, APOE

Products for genes affiliated with Lipoprotein Glomerulopathy

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  • Antibodies
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Sources for Lipoprotein Glomerulopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet