LPG
MCID: LPP002
MIFTS: 40

Lipoprotein Glomerulopathy (LPG) malady

Nephrological diseases, Metabolic diseases, Endocrine diseases categories

Summaries for Lipoprotein Glomerulopathy

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46OMIM, 32MalaCards
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MalaCards: Lipoprotein Glomerulopathy, also known as LPG, is related to nephrotic syndrome and atherosclerosis. An important gene associated with Lipoprotein Glomerulopathy is APOE (apolipoprotein E), and among its related pathways are A-beta Uptake & Degradation and Scavenging by Class A Receptors. The compounds alpha tocopherol and xbai have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are vision/eye and pigmentation.

Description from OMIM:46 611771

Aliases & Classifications for Lipoprotein Glomerulopathy

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46OMIM, 48Orphanet, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases
Anatomical: Nephrological diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
lipoprotein glomerulopathy:
Inheritance: Autosomal dominant; Age of onset: Variable


Aliases & Descriptions:

lipoprotein glomerulopathy 46 48 60
lpg 48


External Ids:

OMIM46 611771

Related Diseases for Lipoprotein Glomerulopathy

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17GeneCards, 18GeneDecks
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Diseases related to Lipoprotein Glomerulopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1nephrotic syndrome30.7ALB, APOB, APOE, LCAT
2atherosclerosis30.3LCAT, APOE, APOB, LDLR, ALB
3psoriasis30.1LDLR
4hypertension30.1APOE, APOB, ALB
5graft versus host disease10.1
6hyperlipoproteinemia type iii10.1
7gamma chain deficiency10.1
8malignant hypertension10.1
9dementia10.0APOE
10complete lcat deficiency10.0LCAT
11peritonitis10.0ALB
12acquired immunodeficiency syndrome10.0ALB
13abdominal aortic aneurysm10.0APOE
14viral hepatitis10.0LCAT
15lung cancer10.0ALB
16gout10.0LCAT
17cystinosis10.0LCAT
18hyperthyroidism10.0LDLR
19glomerulonephritis10.0ALB
20alagille syndrome10.0LCAT
21splenomegaly10.0LCAT
22peripheral vascular disease10.0ALB
23hepatitis10.0LDLR
24vascular dementia10.0APOE
25leukemia10.0LDLR
26familial hypertriglyceridemia10.0APOB
27pick's disease10.0APOE
28hyperhomocysteinemia10.0ALB, APOE
29coronary stenosis10.0APOB
30amyloidosis10.0ALB, APOE
31hyperuricemia10.0APOB
32cholestasis10.0LCAT, ALB
33aortic disease10.0LDLR, APOE
34alcoholic liver cirrhosis10.0ALB, LCAT
35colorectal cancer10.0LDLR
36hepatitis c10.0ALB, LDLR
37metabolic acidosis10.0ALB
38familial combined hyperlipidemia10.0APOB, APOE
39age related macular degeneration10.0APOE, APOB
40focal segmental glomerulosclerosis10.0LCAT, ALB
41galactosemia10.0ALB, LDLR
42acute myocardial infarction10.0APOB, LCAT
43arcus senilis10.0APOB, LCAT
44hypothyroidism10.0APOB, LDLR
45familial hypercholesterolemia10.0LDLR, APOB
46arteriosclerosis10.0APOB, LDLR
47lipodystrophy10.0LDLR, APOB
48uremia10.0ALB, LDLR, LCAT
49liver cirrhosis10.0ALB, LDLR, LCAT
50fatty liver disease10.0APOB, LCAT

Graphical network of the top 20 diseases related to Lipoprotein Glomerulopathy:



Diseases related to lipoprotein glomerulopathy

Clinical Features for Lipoprotein Glomerulopathy

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Sources:
46OMIM
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Clinical features from OMIM:

611771

Drugs & Therapeutics for Lipoprotein Glomerulopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Lipoprotein Glomerulopathy

Drug clinical trials:

Search ClinicalTrials for Lipoprotein Glomerulopathy

Search NIH Clinical Center for Lipoprotein Glomerulopathy

Search CenterWatch for Lipoprotein Glomerulopathy

Genetic Tests for Lipoprotein Glomerulopathy

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Anatomical Context for Lipoprotein Glomerulopathy

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32MalaCards
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MalaCards organs/tissues related to Lipoprotein Glomerulopathy:

32
Kidney

Animal Models for Lipoprotein Glomerulopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lipoprotein Glomerulopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.9LDLR
2MP:00011868.5LDLR, APOB, APOE
3MP:00053858.1LDLR, APOB, APOE, LCAT
4MP:00053707.6ALB, LDLR, APOB, APOE, LCAT
5MP:00053767.2LCAT, APOE, APOB, LDLR, ALB

Publications for Lipoprotein Glomerulopathy

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Genetic Variations for Lipoprotein Glomerulopathy

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Lipoprotein Glomerulopathy:

62
id Symbol AA change Variation ID SNP ID
1APOEp.Arg43CysVAR_042734
2APOEp.Arg163ProVAR_042735

Expression for genes affiliated with Lipoprotein Glomerulopathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lipoprotein Glomerulopathy

Search GEO for disease gene expression data for Lipoprotein Glomerulopathy.

Pathways for genes affiliated with Lipoprotein Glomerulopathy

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Sources:
52R&D Systems, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Lipoprotein Glomerulopathy

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1alpha tocopherol449.8LDLR, LCAT
2xbai449.8LDLR, APOE
3palmitate449.8LDLR, LCAT
4tween 80449.7APOE, ALB
5sele449.5LDLR, APOE
6sitosterol449.4APOE, APOB
722r-hydroxycholesterol44 2810.4LDLR, APOE
8campesterol44 2410.4APOE, APOB
9dimyristoylphosphatidylcholine449.3LDLR, APOE, LCAT
10fructosamine44 2410.2ALB, APOB
11sodium dodecylsulfate449.2ALB, APOE, LCAT
12retinyl palmitate44 2410.1LCAT, APOE, APOB
13intralipid449.1APOB, LCAT, APOE
14cholestyramine449.0LDLR, APOB, APOE
15vitamin b12449.0ALB, APOE, APOB
16lathosterol44 2410.0APOB, LDLR, APOE
174-hydroxynonenal44 2410.0LCAT, APOE, APOB
18psyllium448.9LDLR, LCAT, APOB
19gemfibrozil44 28 1110.9APOE, APOB, LDLR
20ciprofibrate44 289.9LDLR, APOB
21fluvastatin44 49 28 1111.9APOE, APOB, LDLR
22homocysteine44 249.9APOE, APOB, ALB
23rosuvastatin44 49 28 1111.9APOB, ALB, LDLR
24dextran sulfate448.9LDLR, ALB, APOB
25lovastatin44 49 59 28 1112.8APOE, APOB, LDLR
26oleic acid44 28 11 2411.8ALB, LDLR, APOB
27adenine44 11 2410.7LDLR, APOE, APOB
28ascorbic acid44 249.7ALB, LDLR, APOE, LCAT
29probucol44 119.5LCAT, APOE, APOB, LDLR
30cholesterol ester448.5APOE, LCAT, LDLR, APOB
31bezafibrate44 28 1110.5APOB, APOE, LCAT, LDLR
32triacylglycerol448.5APOE, LCAT, APOB, LDLR
33pravastatin44 49 28 11 2412.5APOE, LCAT, LDLR, APOB
34atorvastatin44 49 28 11 2412.5APOB, LDLR, LCAT, APOE
35simvastatin44 49 59 28 11 2413.5APOB, LDLR, LCAT, APOE
36thyroxine44 249.5APOB, LDLR, APOE, ALB
37sterol448.4LCAT, APOE, LDLR, APOB
38folate448.4LDLR, APOB, ALB, APOE
39phosphatidylcholine448.4LDLR, APOB, APOE, LCAT
40phospholipid448.4APOB, LDLR, APOE, LCAT
41glutamine448.4APOB, APOE, LCAT, LDLR
42fatty acid448.3ALB, LDLR, APOB, LCAT
43aspirin44 49 28 2411.3APOE, APOB, LDLR
44glutamate448.1APOE, LCAT, LDLR, APOB
45vitamin a44 11 2410.0LDLR, APOB, APOE, LCAT, ALB
46heparin44 28 11 2411.0LDLR, APOB, APOE, LCAT, ALB
47testosterone44 59 11 2410.9ALB, LDLR, LCAT, APOB, APOE
48cholesterol44 28 11 2410.9LDLR, APOB, APOE, LCAT, ALB
49alanine447.9ALB, LDLR, APOB, APOE, LCAT
50lipid447.9ALB, LDLR, APOB, LCAT, APOE

GO Terms for genes affiliated with Lipoprotein Glomerulopathy

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16Gene Ontology
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Cellular components related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particleGO:0343649.5APOE, LCAT
2intermediate-density lipoprotein particleGO:0343639.4APOB, APOE
3late endosomeGO:0057709.4LDLR, APOE
4chylomicronGO:0426279.4APOB, APOE
5endocytic vesicle lumenGO:0716829.3APOB, APOE
6very-low-density lipoprotein particleGO:0343619.3APOB, APOE
7clathrin-coated endocytic vesicle membraneGO:0306698.9APOB, LDLR
8low-density lipoprotein particleGO:0343628.8LDLR, APOB, APOE
9early endosomeGO:0057698.8APOE, APOB, LDLR
10extracellular spaceGO:0056158.3LCAT, APOE, APOB, ALB
11extracellular regionGO:0055767.9ALB, APOB, APOE, LCAT

Biological processes related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle remodelingGO:0343729.6APOE, LCAT
2high-density lipoprotein particle remodelingGO:0343759.5APOE, LCAT
3reverse cholesterol transportGO:0436919.4LCAT, APOE
4low-density lipoprotein particle remodelingGO:0343749.3APOB, APOE
5artery morphogenesisGO:0488449.2APOB, APOE
6low-density lipoprotein particle clearanceGO:0343839.1APOB, LDLR
7lipoprotein biosynthetic processGO:0421589.0APOB, APOE, LCAT
8cholesterol effluxGO:0333448.9APOB, APOE
9lipoprotein catabolic processGO:0421598.9APOE, APOB, LDLR
10receptor-mediated endocytosisGO:0068988.8LDLR, APOB, APOE
11retinoid metabolic processGO:0015238.8APOE, APOB, LDLR
12cholesterol transportGO:0303018.8LCAT, APOB, LDLR
13phototransduction, visible lightGO:0076038.8APOE, APOB, LDLR
14cholesterol homeostasisGO:0426328.3LCAT, APOE, APOB, LDLR
15cholesterol metabolic processGO:0082038.3LDLR, APOB, APOE, LCAT
16lipoprotein metabolic processGO:0421577.8ALB, LDLR, APOB, APOE, LCAT
17small molecule metabolic processGO:0442817.7ALB, LDLR, APOB, APOE, LCAT

Molecular functions related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antioxidant activityGO:0162099.5ALB, APOE
2cholesterol transporter activityGO:0171279.1APOB, APOE
3low-density lipoprotein particle receptor bindingGO:0507508.9APOB, APOE

Products for genes affiliated with Lipoprotein Glomerulopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lipoprotein Glomerulopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet