MCID: LPP002
MIFTS: 40

Lipoprotein Glomerulopathy malady

Categories: Genetic diseases, Nephrological diseases, Metabolic diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Lipoprotein Glomerulopathy

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Sources:
49OMIM, 11diseasecard, 51Orphanet, 67UniProtKB/Swiss-Prot, 24GTR, 65UMLS, 28ICD10 via Orphanet, 34MedGen
See all MalaCards sources

Aliases & Descriptions for Lipoprotein Glomerulopathy:

Name: Lipoprotein Glomerulopathy 49 11 51 67 24 65
 
Lpg 51 67

Characteristics:

Orphanet epidemiological data:

51
lipoprotein glomerulopathy:
Inheritance: Autosomal dominant; Age of onset: All ages

Classifications:



External Ids:

OMIM49 611771
Orphanet51 329481
ICD10 via Orphanet28 N07.8
MedGen34 C2673196
UMLS65 C2673196

Summaries for Lipoprotein Glomerulopathy

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OMIM:49 Lipoprotein glomerulopathy is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and... (611771) more...

MalaCards based summary: Lipoprotein Glomerulopathy, also known as lpg, is related to myeloma and hepatitis, and has symptoms including renal insufficiency, proteinuria and mesangial abnormality. An important gene associated with Lipoprotein Glomerulopathy is APOE (Apolipoprotein E), and among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism of fat-soluble vitamins. Affiliated tissues include kidney, breast and prostate, and related mouse phenotype pigmentation.

UniProtKB/Swiss-Prot:67 Lipoprotein glomerulopathy: Uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries.

Related Diseases for Lipoprotein Glomerulopathy

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Graphical network of the top 20 diseases related to Lipoprotein Glomerulopathy:



Diseases related to lipoprotein glomerulopathy

Symptoms for Lipoprotein Glomerulopathy

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Clinical features from OMIM:

611771

HPO human phenotypes related to Lipoprotein Glomerulopathy:

id Description Frequency HPO Source Accession
1 renal insufficiency HP:0000083
2 proteinuria HP:0000093
3 mesangial abnormality HP:0001966
4 glomerulopathy HP:0100820

Drugs & Therapeutics for Lipoprotein Glomerulopathy

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Drugs for Lipoprotein Glomerulopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Irbesartanapproved, investigational97138402-11-63749
Synonyms:
138402-11-6
2-Butyl-3-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-1,3-diazaspiro(4.4)non-1-en-4-one
2-Butyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]1,3-diaza-spiro[4.4]non-1-en-4-one
2-Butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
2-butyl-3-[ p -( o -1 H -tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4,4]non-1-en-4-one
2-butyl-3-[2'-(1h-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1,3-diaza-spiro[
2-butyl-3-[2'-(1h-tetrazol-5-yl)biphenyl-4-ylmethyl]1,3-diaza-spiro[
2-butyl-3-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4.4]non-1-en-4-one
2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
2-n-butyl-3-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1,3-diazaspiro(4,4)non-1-en-4-one
8-butyl-7-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-7,9-diazaspiro[4.4]non-8-en-6-one
AC-537
AC1L1GMK
Aprovel
Avalide
Avapro
Avapro (TN)
BIDD:GT0347
BMS 186295
BMS Brand of Irbesartan
BMS-186295
BMS-186295, SR-47436, Aprovel, Karvea, Irbesartan
BRD-K60038276-001-02-5
BSPBio_002687
Bio-0053
Bristol Myers Brand of Irbesartan
C07469
C081309
C25H28N6O
CHEBI:5959
CHEMBL1513
CID3749
CPD000466306
D00523
DB01029
HMS1922J05
HMS2051L08
HMS2093E16
 
I06-0690
Irbesarran
Irbesartan
Irbesartan (JAN/USAN/INN)
Irbesartan [USAN:INN]
Irbesartan [Usan:Inn]
Irbetan
Jsp002315
KBio2_002231
KBio2_004799
KBio2_007367
KBio3_001907
KBioGR_001603
KBioSS_002231
Karvea
L000319
LS-60064
Lrbesartan
MLS000759408
MLS001424099
MolPort-003-666-550
NCGC00095122-01
NCGC00095122-02
NCGC00095122-03
S1507_Selleck
SAM001246548
SMR000466306
SPBio_001889
SPECTRUM1504259
SR 47436
SR-47436
STK645362
Sanofi Winthrop Brand of Irbesartan
Spectrum2_001675
Spectrum3_000994
Spectrum4_001122
Spectrum5_001288
Spectrum_001751
TL8000875
UNII-J0E2756Z7N
irbesartan
2
Sevelamerapproved72152751-57-03085017
Synonyms:
Renagel
Renvela
Sevelamer
Sevelamer Carbonate
 
Sevelamero
Sevelamerum
Sévélamer
sevelamer carbonate
sevelamer hydrochloride
3
Uric Acidexperimental, investigational12069-93-21175
Synonyms:
1H-Purine-2,6,8-triol
2,6,8-Trihydroxypurine
2,6,8-Trioxopurine
2,6,8-Trioxypurine
 
7,9-dihydro-1H-purine-2,6,8(3H)-trione
Lithate
Lithic acid
Purine-2,6,8(1H,3H,9H)-trione
Urate
Uric acid
4Chelating Agents667
5Antihypertensive Agents3618
6Angiotensin II Type 1 Receptor Blockers949
7Angiotensin Receptor Antagonists1039
8Angiotensinogen1032
9
Angiotensin II103368521-88-0, 11128-99-7172198, 65143
Synonyms:
1-8-Angiotensin I
1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide
Ang II
Angiotensin 2
Angiotensin II (human)
 
Angiotensin II (mouse)
Angiotonin
Asp-arg-val-TYR-ile-his-pro-phe
Human angiotensin II
Hypertensin
Ile(5)-angiotensin II

Interventional clinical trials:

idNameStatusNCT IDPhase
1Therapeutic Effect of Immunoadsorption for Patients With Lipoprotein GlomerulopathyCompletedNCT00302510
2A Prospective, Single-center, Randomized, Controlled Study of Sevelamer Carbonate in the Lipid Metabolism and Uric Acid Treatment of Obesity-Related GlomerulopathyNot yet recruitingNCT02644486

Search NIH Clinical Center for Lipoprotein Glomerulopathy

Genetic Tests for Lipoprotein Glomerulopathy

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Anatomical Context for Lipoprotein Glomerulopathy

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MalaCards organs/tissues related to Lipoprotein Glomerulopathy:

33
Kidney, Breast, Prostate, Pituitary, Endothelial, Bone, Temporal lobe

Animal Models for Lipoprotein Glomerulopathy or affiliated genes

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MGI Mouse Phenotypes related to Lipoprotein Glomerulopathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.1APOE, LDLR

Publications for Lipoprotein Glomerulopathy

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Articles related to Lipoprotein Glomerulopathy:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
The Hippo transducers TAZ and YAP in breast cancer: oncogenic activities and clinical implications. (26136233)
2015
2
Olfactory Agenesis in Kallmann Syndrome (KS). (26023587)
2015
3
Rare epileptic syndrome of ring chromosome 20 with epileptic encephalopathy: a case report. (25391199)
2014
4
Validation study of genes with hypermethylated promoter regions associated with prostate cancer recurrence. (24718283)
2014
5
Global progress towards regional measles elimination, worldwide, 2000a892013. (25401192)
2014
6
Catastrophic osteomyelitis following percutaneous wire fixation of a distal radial fracture: a cautionary tale of poor patient selection followed by surgical mishap. (23355597)
2013
7
Epidemiology of hemorrhagic fever with renal syndrome in Korea, 2001-2010. (24133366)
2013
8
A novel kindling model of temporal lobe epilepsy in rhesus monkeys induced by Coriaria lactone. (24100251)
2013
9
Combination Therapy of Ursodeoxycholic Acid and Corticosteroids for Primary Biliary Cirrhosis with Features of Autoimmune Hepatitis: A Meta-Analysis. (24369456)
2013
10
Identification of nucleic acid binding sites on translin-associated factor X (TRAX) protein. (22427937)
2012
11
The temporal association of sphenoid sinus mucosal thickening on MR imaging with pituitary apoplexy. (23208917)
2012
12
The cerebrospinal fluid amyloid beta42/40 ratio in the differentiation of Alzheimer's disease from non-Alzheimer's dementia. (20043812)
2010
13
Familial nonkinesigenic paroxysmal dyskinesia and intracranial calcifications: a new syndrome? (20803517)
2010
14
p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint. (19528229)
2009
15
Catecholamine-induced cardiomyopathy. (19158054)
2008
16
Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells. (18820264)
2008
17
Self-microemulsifying drug delivery system (SMEDDS) improves anticancer effect of oral 9-nitrocamptothecin on human cancer xenografts in nude mice. (18434109)
2008
18
Antiproliferative effect of Scutellaria barbata D. Don. on cultured human uterine leiomyoma cells by down-regulation of the expression of Bcl-2 protein. (18444248)
2008
19
The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. (17258231)
2007
20
Synthetic agonists of Toll-like receptors 7, 8 and 9. (18031246)
2007
21
Potential use of Trichinella spiralis antigen for serodiagnosis of human capillariasis philippinensis by immunoblot analysis. (16333664)
2006
22
Bone disease in primary biliary cirrhosis: lack of association with distal renal tubular acidosis. (15610460)
2005
23
PPAR gamma as a metabolic regulator: insights from genomics and pharmacology. (15673477)
2005
24
Regulation of the human vitamin D3 receptor promoter in breast cancer cells is mediated through Sp1 sites. (15664452)
2005
25
Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density. (15454103)
2004
26
Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro. (15651750)
2004
27
Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies. (14572447)
2003
28
Hepatoma derived growth factor is a nuclear targeted mitogen. (12816346)
2003
29
Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. (12617994)
2003
30
The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (11984006)
2002
31
Pseudo-outbreak of Mycobacterium fortuitum on a Human Immunodeficiency Virus Ward: transient respiratory tract colonization from a contaminated ice machine. (12060872)
2002
32
Eosinophilic cystitis in a 4-year-old boy: successful long-term treatment with cyclosporin A. (11731640)
2001
33
Histologic classification of tumor-infiltrating lymphocytes in primary cutaneous malignant melanoma. A study of interobserver agreement. (11392882)
2001
34
Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer. (11597015)
2001
35
Impaired contractile response of mesenteric arteries in Crohn's disease. (11012472)
2000
36
Anti-inflammatory action of type I interferons deduced from mice expressing interferon beta. (10845718)
2000
37
The subapical actin cytoskeleton regulates secretion and membrane retrieval in pancreatic acinar cells. (9841906)
1999
38
Flow cytometric detection of type 1 (IL-2, IFN-gamma) and type 2 (IL-4, IL-5) cytokines in T-helper and T-suppressor/cytotoxic cells in rheumatoid arthritis, allergic asthma and atopic dermatitis. (10525317)
1999
39
Gender differences in cardiovascular risk factors in obese, nondiabetic first degree relatives of African Americans with type 2 diabetes mellitus. (9926902)
1998
40
Inhibition of growth of androgen-independent DU-145 prostate cancer in vivo by luteinising hormone-releasing hormone antagonist Cetrorelix and bombesin antagonists RC-3940-II and RC-3950-II. (9376196)
1997
41
Evaluation of N-acetyl-beta glucosaminidase in upper and lower urinary tract infections in childhood. Clinical study of 168 children]. (9064498)
1996
42
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. (8673700)
1996
43
Lack of reactivity of paracoccidioidomycosis sera in the double immunodiffusion test with the gp43 antigen: report of two cases. (7658301)
1995
44
Gene expression of plasminogen activator inhibitor 1 in transplant kidneys complicated by renal vein thrombosis: a combined study by in-situ hybridization and immunohistochemistry. (8052438)
1994
45
Focal adhesion-associated proteins p125FAK and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells. (7929090)
1994
46
The uptake of 3H-labelled monodeoxyfluoro-myo-inositols into thymocytes and their incorporation into phospholipid in permeabilized cells. (8387272)
1993
47
Managing impotence in diabetes. Two drugs are better than one. (8401115)
1993
48
Hereditary anaemias in Portugal: epidemiology, public health significance, and control. (8474108)
1993
49
Adult Fanconi syndrome in primary amyloidosis with lambda light-chain proteinuria. (2509772)
1989
50
Electroconvulsive shock, retrograde amnesia, and competing responses. (13859327)
1962

Variations for Lipoprotein Glomerulopathy

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UniProtKB/Swiss-Prot genetic disease variations for Lipoprotein Glomerulopathy:

67
id Symbol AA change Variation ID SNP ID
1APOEp.Arg43CysVAR_042734
2APOEp.Arg163ProVAR_042735

Clinvar genetic disease variations for Lipoprotein Glomerulopathy:

5
id Gene Variation Type Significance SNP ID Assembly Location
1APOENM_000041.3(APOE): c.488G> C (p.Arg163Pro)single nucleotide variantPathogenicrs121918397GRCh37Chr 19, 45412041: 45412041
2APOENM_000041.3(APOE): c.127C> T (p.Arg43Cys)single nucleotide variantPathogenicrs121918399GRCh37Chr 19, 45411100: 45411100

Expression for genes affiliated with Lipoprotein Glomerulopathy

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Search GEO for disease gene expression data for Lipoprotein Glomerulopathy.

Pathways for genes affiliated with Lipoprotein Glomerulopathy

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Pathways related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.1APOE, LDLR
2
Show member pathways
9.1APOE, LDLR
3
Show member pathways
9.1APOE, LDLR
4
Show member pathways
9.1APOE, LDLR
59.1APOE, LDLR

GO Terms for genes affiliated with Lipoprotein Glomerulopathy

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Biological processes related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein catabolic processGO:00421599.4APOE, LDLR
2cholesterol homeostasisGO:00426329.1APOE, LDLR
3cholesterol metabolic processGO:00082038.8APOE, LDLR

Sources for Lipoprotein Glomerulopathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet