LPG
MCID: LPP002
MIFTS: 39

Lipoprotein Glomerulopathy (LPG) malady

Nephrological, Metabolic, Endocrine categories

Summaries for Lipoprotein Glomerulopathy

Sources:
47OMIM, 33MalaCards
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MalaCards: Lipoprotein Glomerulopathy, also known as LPG, is related to atherosclerosis and n syndrome. An important gene associated with Lipoprotein Glomerulopathy is APOE (apolipoprotein E), and among its related pathways are A-beta Uptake & Degradation and Scavenging by Class A Receptors. The compounds alpha tocopherol and xbai have been mentioned in the context of this disorder. Affiliated tissues include kidney and endothelial, and related mouse phenotypes are vision/eye and pigmentation.

Description from OMIM:47 611771

Aliases & Classifications for Lipoprotein Glomerulopathy

Sources:
47OMIM, 49Orphanet, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological, Metabolic, Endocrine


Characteristics (Orphanet epidemiological data):

49
lipoprotein glomerulopathy:
Inheritance: Autosomal dominant; Age of onset: Variable


Aliases & Descriptions:

lipoprotein glomerulopathy 47 49 61
lpg 49


External Ids:

OMIM47 611771

Related Diseases for Lipoprotein Glomerulopathy

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lipoprotein Glomerulopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.3LCAT, APOE, APOB, LDLR, ALB
2n syndrome10.5
3lip disease10.4
4graft versus host disease10.1
5apo a-i deficiency10.1
6chronic graft versus host disease10.1
7dementia10.0APOE
8complete lcat deficiency10.0LCAT
9peritonitis10.0ALB
10acquired immunodeficiency syndrome10.0ALB
11abdominal aortic aneurysm10.0APOE
12viral hepatitis10.0LCAT
13lung cancer10.0ALB
14gout10.0LCAT
15psoriasis10.0LDLR
16cystinosis10.0LCAT
17hyperthyroidism10.0LDLR
18glomerulonephritis10.0ALB
19alagille syndrome10.0LCAT
20splenomegaly10.0LCAT
21peripheral vascular disease10.0ALB
22hepatitis10.0LDLR
23vascular dementia10.0APOE
24leukemia10.0LDLR
25familial hypertriglyceridemia10.0APOB
26pick's disease10.0APOE
27hyperhomocysteinemia10.0ALB, APOE
28coronary stenosis10.0APOB
29amyloidosis10.0ALB, APOE
30hyperuricemia10.0APOB
31cholestasis10.0LCAT, ALB
32aortic disease10.0LDLR, APOE
33alcoholic liver cirrhosis10.0ALB, LCAT
34colorectal cancer10.0LDLR
35hepatitis c10.0ALB, LDLR
36metabolic acidosis10.0ALB
37familial combined hyperlipidemia10.0APOB, APOE
38age related macular degeneration10.0APOE, APOB
39focal segmental glomerulosclerosis10.0LCAT, ALB
40galactosemia10.0ALB, LDLR
41acute myocardial infarction10.0APOB, LCAT
42arcus senilis10.0APOB, LCAT
43hypothyroidism10.0APOB, LDLR
44familial hypercholesterolemia10.0LDLR, APOB
45arteriosclerosis10.0APOB, LDLR
46lipodystrophy10.0LDLR, APOB
47uremia10.0ALB, LDLR, LCAT
48liver cirrhosis10.0ALB, LDLR, LCAT
49fatty liver disease10.0APOB, LCAT
50prion disease10.0APOB, APOE

Graphical network of the top 20 diseases related to Lipoprotein Glomerulopathy:



Diseases related to lipoprotein glomerulopathy

Clinical Features for Lipoprotein Glomerulopathy

Sources:
47OMIM
See all sources

Clinical features from OMIM:

611771

Drugs & Therapeutics for Lipoprotein Glomerulopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Lipoprotein Glomerulopathy

Drug clinical trials:

Search ClinicalTrials for Lipoprotein Glomerulopathy

Search NIH Clinical Center for Lipoprotein Glomerulopathy

Search CenterWatch for Lipoprotein Glomerulopathy

Genetic Tests for Lipoprotein Glomerulopathy

Anatomical Context for Lipoprotein Glomerulopathy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Lipoprotein Glomerulopathy:

33
Kidney, Endothelial

Animal Models for Lipoprotein Glomerulopathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Lipoprotein Glomerulopathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.9LDLR
2MP:00011868.5LDLR, APOB, APOE
3MP:00053858.1LDLR, APOB, APOE, LCAT
4MP:00053707.6ALB, LDLR, APOB, APOE, LCAT
5MP:00053767.2LCAT, APOE, APOB, LDLR, ALB

Publications for Lipoprotein Glomerulopathy

Sources:
51PubMed
See all sources

Articles related to Lipoprotein Glomerulopathy:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Lipoprotein glomerulopathy associated with a mutation in apolipoprotein e. (24348079)
2013
2
A case of lipoprotein glomerulopathy with thrombotic microangiopathy due to malignant hypertension. (23448537)
2013
3
A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy. (24149834)
2013
4
Lipoprotein glomerulopathy in China. (24165683)
2013
5
A founder haplotype of APOE-Sendai mutation associated with lipoprotein glomerulopathy. (23407349)
2013
6
Identification of a mutation in exon 4 of apolipoprotein E gene in a family affected with lipoprotein glomerulopathy]. (22487820)
2012
7
Macrophage impairment produced by Fc receptor gamma deficiency plays a principal role in the development of lipoprotein glomerulopathy in concert with apoE abnormalities. (22863838)
2012
8
A rare cause of childhood-onset nephrotic syndrome: lipoprotein glomerulopathy. (22874113)
2012
9
A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy. (21325775)
2011
10
Lipoprotein glomerulopathy: first report of 2 not consanguineous Italian men from the same town. (21534236)
2011
11
Lipoprotein glomerulopathy. (21464714)
2011
12
A new apolipoprotein E mutation, apoE Las Vegas, in a European-American with lipoprotein glomerulopathy. (20624773)
2010
13
A rare case of lipoprotein glomerulopathy in a white man: an emerging entity in Asia, rare in the white population. (20121619)
2010
14
Successful treatment of lipoprotein glomerulopathy in a daughter and a mother using niceritrol. (20842518)
2010
15
Common apolipoprotein E gene mutations contribute to lipoprotein glomerulopathy in China. (20090368)
2010
16
Lipoprotein glomerulopathy induced by ApoE-Sendai is different from glomerular lesions in aged apoE-deficient mice. (19459027)
2009
17
A rare cause of nephrotic syndrome: lipoprotein glomerulopathy. (19197098)
2009
18
Lipoprotein glomerulopathy treated with LDL-apheresis (Heparin-induced Extracorporeal Lipoprotein Precipitation system): a case report. (20062740)
2009
19
A novel apolipoprotein E mutation, ApoE Tsukuba (Arg 114 Cys), in lipoprotein glomerulopathy. (17967799)
2008
20
Renal failure with intracapillary thrombi. Lipoprotein glomerulopathy. (18414445)
2008
21
Identification of apolipoprotein E Guangzhou (arginine 150 proline), a new variant associated with lipoprotein glomerulopathy. (18046082)
2008
22
Clinicopathological and genetic characteristics in Chinese patients with lipoprotein glomerulopathy. (18264944)
2008
23
Lipoprotein glomerulopathy-like disease in a patient with type III hyperlipoproteinemia due to apolipoprotein E2 (Arg158 Cys)/3 heterozygosity. (17593519)
2007
24
APOE Kyoto mutation in European Americans with lipoprotein glomerulopathy. (18077821)
2007
25
Lipoprotein glomerulopathy: a new apolipoprotein E mutation with enhanced glomerular binding. (16490634)
2006
26
Impact of lipoprotein glomerulopathy on the relationship between lipids and renal diseases. (16431249)
2006
27
Plasma level and genetic variation of apolipoprotein E in patients with lipoprotein glomerulopathy. (15820086)
2005
28
Clinical and pathological analyses of lipoprotein glomerulopathy]. (15181857)
2004
29
Disappearance of intraglomerular lipoprotein thrombi and marked improvement of nephrotic syndrome by bezafibrate treatment in a patient with lipoprotein glomerulopathy. (12921981)
2003
30
Etiological significance of apolipoprotein E mutations in lipoprotein glomerulopathy. (11852253)
2002
31
Interaction of endothelial cells and triglyceride-rich lipoproteins with apolipoprotein E (Arg-->Cys) from a patient with lipoprotein glomerulopathy. (11833049)
2002
32
A new variant of apolipoprotein E (apo E Maebashi) in lipoprotein glomerulopathy. (10684367)
2000
33
Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice. (10903326)
2000
34
Apolipoprotein E2/E5 variants in lipoprotein glomerulopathy recurred in transplanted kidney. (10405216)
1999
35
A novel 18-amino acid deletion in apolipoprotein E associated with lipoprotein glomerulopathy. (10504484)
1999
36
Lipoprotein glomerulopathy: significance of lipoprotein and ultrastructural features. (10412734)
1999
37
Lipoprotein glomerulopathy: a new cause of nephrotic syndrome after renal transplantation. Implications for renal transplantation. (10052520)
1999
38
Lipoprotein glomerulopathy: renal lipidosis induced by novel apolipoprotein E variants. (10529625)
1999
39
Association of a novel 3-amino acid deletion mutation of apolipoprotein E (Apo E Tokyo) with lipoprotein glomerulopathy. (10529627)
1999
40
Lipoprotein glomerulopathy: a new cause of nephrotic syndrome after renal transplantation. (9623574)
1998
41
Lipoprotein glomerulopathy: a pediatric case report. (9090668)
1997
42
Lipoprotein glomerulopathy: a new role for apolipoprotein E? (9176856)
1997
43
Apolipoprotein E Sendai (arginine 145-->proline): a new variant associated with lipoprotein glomerulopathy. (9176854)
1997
44
Recurrence of lipoprotein glomerulopathy after renal transplantation. (9394344)
1997
45
Lipoprotein glomerulopathy: first case in a white European. (7624001)
1995
46
Lipoprotein glomerulopathy with a new apolipoprotein E phenotype. (7771495)
1995
47
Lipoprotein glomerulopathy: first report in a Chinese male. (7985674)
1994
48
Abnormal lipoprotein and apolipoprotein pattern in lipoprotein glomerulopathy. (1951334)
1991
49
Lipoprotein glomerulopathy: glomerular lipoprotein thrombi in a patient with hyperlipoproteinemia. (2644825)
1989
50
Similarities between glomerular sclerosis and atherosclerosis in human renal biopsy specimens: a role for lipoprotein glomerulopathy. (2486545)
1989

Genetic Variations for Lipoprotein Glomerulopathy

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Lipoprotein Glomerulopathy:

63
id Symbol AA change Variation SNP ID
1APOEp.Arg43CysVAR_042734
2APOEp.Arg163ProVAR_042735

Expression for genes affiliated with Lipoprotein Glomerulopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lipoprotein Glomerulopathy

Search GEO for disease gene expression data for Lipoprotein Glomerulopathy.

Pathways for genes affiliated with Lipoprotein Glomerulopathy

Sources:
53R&D Systems, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 50PharmGKB
See all sources

Compounds for genes affiliated with Lipoprotein Glomerulopathy

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1alpha tocopherol459.8LDLR, LCAT
2xbai459.8LDLR, APOE
3palmitate459.8LDLR, LCAT
4tween 80459.7APOE, ALB
5sele459.5LDLR, APOE
6sitosterol459.4APOE, APOB
722r-hydroxycholesterol45 2910.4LDLR, APOE
8campesterol45 2410.4APOB, APOE
9dimyristoylphosphatidylcholine459.3LCAT, APOE, LDLR
10fructosamine45 2410.2APOB, ALB
11sodium dodecylsulfate459.2ALB, APOE, LCAT
12retinyl palmitate45 2410.1APOB, APOE, LCAT
13intralipid459.1APOB, APOE, LCAT
14cholestyramine459.0APOE, APOB, LDLR
15vitamin b12459.0ALB, APOB, APOE
16lathosterol45 2410.0LDLR, APOB, APOE
174-hydroxynonenal45 2410.0APOB, APOE, LCAT
18psyllium458.9LCAT, APOB, LDLR
19gemfibrozil45 29 1110.9APOE, APOB, LDLR
20ciprofibrate45 299.9LDLR, APOB
21fluvastatin45 50 29 1111.9APOE, APOB, LDLR
22homocysteine45 249.9ALB, APOB, APOE
23rosuvastatin45 50 29 1111.9ALB, LDLR, APOB
24dextran sulfate458.9ALB, LDLR, APOB
25lovastatin45 50 60 29 1112.8APOE, APOB, LDLR
26oleic acid45 29 11 2411.8ALB, LDLR, APOB
27adenine45 11 2410.7LDLR, APOB, APOE
28ascorbic acid45 249.7LCAT, APOE, LDLR, ALB
29probucol45 119.5LCAT, APOE, APOB, LDLR
30cholesterol ester458.5LCAT, APOE, APOB, LDLR
31bezafibrate45 29 1110.5LDLR, APOB, APOE, LCAT
32triacylglycerol458.5LDLR, APOB, APOE, LCAT
33pravastatin45 50 29 11 2412.5LCAT, APOE, APOB, LDLR
34atorvastatin45 50 29 11 2412.5LCAT, APOE, APOB, LDLR
35simvastatin45 50 60 29 11 2413.5LCAT, APOE, APOB, LDLR
36thyroxine45 249.5APOE, APOB, LDLR, ALB
37sterol458.4LCAT, APOE, APOB, LDLR
38folate458.4APOE, APOB, LDLR, ALB
39phosphatidylcholine458.4LCAT, APOE, APOB, LDLR
40phospholipid458.4LCAT, APOE, APOB, LDLR
41glutamine458.4LDLR, APOB, APOE, LCAT
42fatty acid458.3LCAT, APOB, LDLR, ALB
43aspirin45 50 29 2411.3LDLR, APOB, APOE
44glutamate458.1LCAT, APOE, APOB, LDLR
45vitamin a45 11 2410.0LCAT, APOE, APOB, LDLR, ALB
46heparin45 29 11 2411.0LCAT, APOE, APOB, LDLR, ALB
47testosterone45 60 11 2410.9LCAT, APOE, APOB, LDLR, ALB
48cholesterol45 29 11 2410.9ALB, LDLR, APOB, APOE, LCAT
49alanine457.9ALB, LDLR, APOB, APOE, LCAT
50lipid457.9LCAT, APOE, APOB, LDLR, ALB

GO Terms for genes affiliated with Lipoprotein Glomerulopathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particleGO:0343649.5APOE, LCAT
2intermediate-density lipoprotein particleGO:0343639.4APOB, APOE
3late endosomeGO:0057709.4LDLR, APOE
4chylomicronGO:0426279.4APOB, APOE
5endocytic vesicle lumenGO:0716829.3APOB, APOE
6very-low-density lipoprotein particleGO:0343619.3APOB, APOE
7clathrin-coated endocytic vesicle membraneGO:0306698.9APOB, LDLR
8low-density lipoprotein particleGO:0343628.8LDLR, APOB, APOE
9early endosomeGO:0057698.8APOE, APOB, LDLR
10extracellular spaceGO:0056158.3LCAT, APOE, APOB, ALB
11extracellular regionGO:0055767.9ALB, APOB, APOE, LCAT

Biological processes related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particle remodelingGO:0343729.6APOE, LCAT
2high-density lipoprotein particle remodelingGO:0343759.5APOE, LCAT
3reverse cholesterol transportGO:0436919.4LCAT, APOE
4low-density lipoprotein particle remodelingGO:0343749.3APOB, APOE
5artery morphogenesisGO:0488449.2APOB, APOE
6low-density lipoprotein particle clearanceGO:0343839.1APOB, LDLR
7lipoprotein biosynthetic processGO:0421589.0APOB, APOE, LCAT
8cholesterol effluxGO:0333448.9APOB, APOE
9lipoprotein catabolic processGO:0421598.9APOE, APOB, LDLR
10receptor-mediated endocytosisGO:0068988.8LDLR, APOB, APOE
11retinoid metabolic processGO:0015238.8APOE, APOB, LDLR
12cholesterol transportGO:0303018.8LCAT, APOB, LDLR
13phototransduction, visible lightGO:0076038.8APOE, APOB, LDLR
14cholesterol homeostasisGO:0426328.3LCAT, APOE, APOB, LDLR
15cholesterol metabolic processGO:0082038.3LDLR, APOB, APOE, LCAT
16lipoprotein metabolic processGO:0421577.8ALB, LDLR, APOB, APOE, LCAT
17small molecule metabolic processGO:0442817.7ALB, LDLR, APOB, APOE, LCAT

Molecular functions related to Lipoprotein Glomerulopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antioxidant activityGO:0162099.5ALB, APOE
2cholesterol transporter activityGO:0171279.1APOB, APOE
3low-density lipoprotein particle receptor bindingGO:0507508.9APOB, APOE

Products for genes affiliated with Lipoprotein Glomerulopathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lipoprotein Glomerulopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet