Aliases & Classifications for Liposarcoma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 61UMLS, 56SNOMED-CT, 33MeSH, 39NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Liposarcoma:

Name: Liposarcoma 8 42 10 44 48 61


Classifications:

Orphanet: 48 
Rare tumors


Characteristics (Orphanet epidemiological data):

48
liposarcoma:
Prevalence: 1-9/100000 (Europe); Age of onset: All ages


External Ids:

Disease Ontology8 DOID:3382
MeSH33 D008080
NCIt39 C3194
Orphanet48 69078
MESH via Orphanet34 D008080
ICD10 via Orphanet26 C49
UMLS via Orphanet62 C0023827

Summaries for Liposarcoma

About this section
NIH Rare Diseases:42 Liposarcoma is a tumor that arises from fat tissue.  this tumor often occurs in the thigh, behind the knee, or in the abdomen, but it can be found in other parts of the body.  because a liposarcoma may grow into surrounding tissues or organs, it is considered a malignant tumor. last updated: 2/18/2011

MalaCards based summary: Liposarcoma is related to pleomorphic liposarcoma and myxoid liposarcoma, and has symptoms including abnormality of the skin, sarcoma and abnormality of the urinary system. An important gene associated with Liposarcoma is FUS (fused in sarcoma), and among its related pathways are DNA damage ATM ATR regulation of G1 S checkpoint and Oncogene Induced Senescence. The compounds roscovitine and benzo(a)pyrene have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lung, and related mouse phenotypes are limbs/digits/tail and adipose tissue.

Disease Ontology:8 A lipomatous cancer that arises in fat cells in deep soft tissue retroperitoneum.

Wikipedia:64 Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the... more...

Related Diseases for Liposarcoma

About this section

Diseases in the Liposarcoma family:

Inflammatory Liposarcoma Adult Liposarcoma

Diseases related to Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1pleomorphic liposarcoma31.7KIT, MDM2
2myxoid liposarcoma31.4ATF1, FUS, EWSR1, MDM2, CDK4
3lipoma31.0DES, FUS, HMGA2, MDM2, CDK4
4dedifferentiated liposarcoma30.9CDK4, MDM2, RB1, HMGA2, KIT, DES
5fibrous histiocytoma30.8DES, ATF1, FUS
6angiomyolipoma30.7KIT, DES
7hemangiopericytoma30.5MDM2, DES
8li-fraumeni syndrome30.4MDM2, RB1
9desmoplastic small round cell tumor30.3EWSR1, DES
10leiomyoma30.2HMGA2, KIT, DES
11desmoid disease, hereditary30.2DES, KIT
12leiomyosarcoma30.2DES, KIT, RB1, MDM2, CDK4
13dermatofibrosarcoma protuberans30.2KIT, DES
14pleomorphic adenoma30.1MDM2, HMGA2, DES
15malignant peripheral nerve sheath tumor30.1KIT, MDM2
16rhabdomyosarcoma30.0DES, EWSR1, RB1, MDM2, CDK4
17adenoma29.9PPARG, HMGA2, RB1, CDK4
18b-cell lymphomas29.8HMGA2, RB1, MDM2, CDK4
19adenocarcinoma29.8CDK4, MDM2, RB1, HMGA2
20retinoblastoma29.7PPARG, RB1, MDM2, CDK4
21clear cell sarcoma29.6ATF1, FUS, EWSR1, KIT
22colorectal cancer29.6PPARG, RB1, MDM2, CDK4
23chondrosarcoma29.5DES, FUS, EWSR1, HMGA2, MDM2, CDK4
24sarcoma29.5EWSR1, FUS, ATF1, DES, KIT, HMGA2
25prostate cancer29.4LRP1, RB1, CDK4
26leukemia29.2ATF1, FUS, EWSR1, KIT, HMGA2, RB1
27melanoma28.6DES, ATF1, LRP1, EWSR1, KIT, RB1
28breast cancer28.3PPARG, ATF1, LRP1, KIT, HMGA2, RB1
29retroperitoneal liposarcoma11.0
30mediastinitis10.6
31myxoid/round cell liposarcoma10.5
32chondroma10.5HMGA2
33atypical lipomatous tumor10.5
34spindle cell liposarcoma10.5
35adenosarcoma10.5DES
36giant cell glioblastoma10.5MDM2
37gliosarcoma10.4CDK4
38myelofibrosis10.4HMGA2
39carney triad10.4KIT
40histiocytoma10.4
41inflammatory liposarcoma10.4
42connective tissue benign neoplasm10.4CDK4, MDM2
43liposarcoma of bone10.3
44anaplastic oligodendroglioma10.3CDK4, MDM2
45gastric liposarcoma10.3
46liposarcoma of the ovary10.3
47myxoid liposarcoma of the ovary10.3
48mixed liposarcoma10.3
49breast liposarcoma10.3
50retinoblastoma fa - friedreich ataxia10.3RB1, MDM2

Graphical network of the top 20 diseases related to Liposarcoma:



Diseases related to liposarcoma

Symptoms for Liposarcoma

About this section

Symptoms:

 48
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • acute abdominal pain/colic
  • intestinal transit disorder
  • functional anomalies of the kidney and the urinary tract
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Liposarcoma:

(show all 6)
id Description Frequency HPO Source Accession
1 abnormality of the skin hallmark (90%) HP:0000951
2 sarcoma hallmark (90%) HP:0100242
3 abnormality of the urinary system occasional (7.5%) HP:0000079
4 abdominal pain occasional (7.5%) HP:0002027
5 abnormality of the intestine occasional (7.5%) HP:0002242
6 neoplasm of the lung occasional (7.5%) HP:0100526

Drugs & Therapeutics for Liposarcoma

About this section

Drug clinical trials:

Search ClinicalTrials for Liposarcoma

Search NIH Clinical Center for Liposarcoma

Genetic Tests for Liposarcoma

About this section

Anatomical Context for Liposarcoma

About this section

MalaCards organs/tissues related to Liposarcoma:

31
Bone, Breast, Lung, Colon, Liver, Adipocyte, Kidney, Heart, Thyroid, Skin, Ovary, Prostate, Tongue, Bone marrow, Smooth muscle, Pancreas, Uterus, Testes, Myeloid, B cells, Lymph node, Spleen, Small intestine, Salivary gland, Adrenal gland, Testis, Appendix

Animal Models for Liposarcoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Liposarcoma:

35 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.6KIT, HMGA2, RB1, MDM2
2MP:00053758.5RB1, PPARG, LRP1, EWSR1, HMGA2
3MP:00053778.4RB1, HMGA2, KIT, PPARG
4MP:00053678.3MDM2, CDK4, KIT, EWSR1, PPARG
5MP:00030128.2KIT, FUS, PPARG, MDM2, RB1
6MP:00020068.1RB1, CDK4, EWSR1, PPARG, KIT, MDM2
7MP:00053797.9EWSR1, FUS, PPARG, CDK4, RB1, HMGA2
8MP:00107717.8RB1, MDM2, PPARG, EWSR1, HMGA2, KIT
9MP:00053707.8LRP1, PPARG, CDK4, KIT, RB1, MDM2
10MP:00053907.6KIT, EWSR1, LRP1, PPARG, RB1, MDM2
11MP:00053857.4LRP1, KIT, RB1, MDM2, CDK4, DES
12MP:00053807.3PPARG, RB1, MDM2, KIT, LRP1, CDK4
13MP:00053847.2RB1, PPARG, ATF1, FUS, EWSR1, KIT
14MP:00028737.2PPARG, MDM2, RB1, KIT, EWSR1, LRP1
15MP:00053697.2MDM2, RB1, PPARG, DES, LRP1, EWSR1
16MP:00053977.2RB1, KIT, MDM2, FUS, LRP1, PPARG
17MP:00053867.0LRP1, FUS, KIT, DES, HMGA2, CDK4
18MP:00053897.0CDK4, PPARG, LRP1, FUS, EWSR1, KIT
19MP:00053786.9PPARG, LRP1, FUS, EWSR1, KIT, HMGA2
20MP:00053766.9DES, PPARG, HMGA2, KIT, LRP1, RB1
21MP:00036316.8FUS, CDK4, MDM2, RB1, LRP1, KIT
22MP:00053876.7LRP1, ATF1, PPARG, FUS, EWSR1, KIT
23MP:00107686.4PPARG, KIT, CDK4, RB1, MDM2, ATF1

Publications for Liposarcoma

About this section

Articles related to Liposarcoma:

(show top 50)    (show all 1084)
idTitleAuthorsYear
1
Deregulation of dicer and mir-155 expression in liposarcoma. (25888631)
2015
2
Extensive lipoma-like changes of myxoid liposarcoma: morphologic, immunohistochemical, and molecular cytogenetic analyses. (25650275)
2015
3
Giant retroperitoneal liposarcoma during pregnancy: a case report. (25886056)
2015
4
Retroperitoneal perirenal myxoid liposarcoma. (25750026)
2015
5
Primary dedifferentiated liposarcoma of the lung with rhabdomyoblastic and chrondroblastic differentiation. (24612243)
2014
6
Nuclear Expression of STAT6 in Dedifferentiated Liposarcomas With a Solitary Fibrous Tumor-like Morphology: A Diagnostic Pitfall. (25075469)
2014
7
Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma. (24788530)
2014
8
Estrogen receptor alpha and androgen receptor are commonly expressed in well-differentiated liposarcoma. (25349530)
2014
9
Cyclin-dependent kinase inhibitor 2A (p16) distinguishes well-differentiated liposarcoma from lipoma. (23600700)
2013
10
Palmar well differentiated spindle cell liposarcoma: presentation of a rare tumor at a rare site. (23413865)
2013
11
A mediastinal liposarcoma resected using a double approach with a thoracoscope. (25360414)
2013
12
Spermatic cord liposarcoma: organ-sparing surgery. (23814206)
2013
13
Huge mesenteric liposarcoma. (23901685)
2013
14
Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma. (23393200)
2013
15
Dedifferentiated liposarcoma of the retroperitoneum with osteosarcomatous component. (23426961)
2013
16
Lipoma or liposarcoma? A cautionary case report. (21865105)
2012
17
A huge retroperitoneal liposarcoma presenting as a hepatic space-occupying lesion: a case report. (22257481)
2012
18
Malignant nature of cardiac liposarcoma revealed by fluorine-18 fluorodeoxyglucose positron emission tomographic imaging. (22687843)
2012
19
Dedifferentiated subserosal liposarcoma of the jejunum: sonographic and computed tomographic findings with pathologic correlation. (22726982)
2012
20
The well-differentiated liposarcoma of the hypopharynx. (21602115)
2011
21
Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis. (21335544)
2011
22
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
23
Successful thoracoscopic resection of a large mediastinal liposarcoma. (21958801)
2011
24
Giant liposarcoma of the esophagus with Li-Fraumeni-like syndrome. (21454085)
2011
25
Composite reconstruction with cryopreserved fascia lata, single mandibular titanium plate, and polyglactin mesh after redo surgery and radiation therapy for recurrent chest wall liposarcoma. (20674942)
2011
26
Myxoid liposarcoma with EWS-CHOP type 1 fusion gene. (21115923)
2010
27
Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature. (20604797)
2010
28
Liposarcoma of the spermatic cord: a diagnostic dilemma. (21234112)
2010
29
Liposarcoma: exploration of clinical prognostic factors for risk based stratification of therapy. (19558664)
2009
30
Effects of nutritional antioxidants on AAPH- or AGEs-induced oxidative stress in human SW872 liposarcoma cells. (19152116)
2009
31
Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue. (18269578)
2008
32
Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. (16849546)
2006
33
MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. (16160477)
2005
34
Inguinal dedifferentiated liposarcoma with meningothelial-like whorls and metaplastic bone formation. (15842647)
2005
35
Radiology: radiology quiz case 2. Atypical lipomatous tumor, a variant of well-differentiated liposarcoma. (12525210)
2003
36
The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma. (10755400)
2000
37
Biochemical uncovering of mdm2/p53 complexes in liposarcomas parallels their immunohistochemical detection. (10565683)
1999
38
Distinct mdm2/p53 expression patterns in liposarcoma subgroups: implications for different pathogenetic mechanisms. (9071998)
1997
39
Complexity of 12q13-22 amplicon in liposarcoma: microsatellite repeat analysis. (8993982)
1997
40
Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction. (9311018)
1997
41
Gastric liposarcoma: CT appearance. (8508081)
1993
42
Paradoxical cerebral embolism originating from thrombus in tumour veins as presenting manifestation of retroperitoneal liposarcoma. (8461249)
1993
43
Divergent myosarcomatous differentiation in retroperitoneal liposarcoma. (8333554)
1993
44
General case of the day. Myxoid liposarcoma. (2028068)
1991
45
Chromosomal evolution and tumor progression in a myxoid liposarcoma. (2193480)
1990
46
A complex translocation involving chromosomes 12 and 16 in a metastatic myxoid liposarcoma. (3395986)
1988
47
Case profile: computed tomography in retroperitoneal liposarcoma. (6868241)
1983
48
Crystalline inculsion in myxoid liposarcoma. (7282368)
1981
49
Ultrasonography and computed tomography of retroperitoneal liposarcoma. (7273837)
1981
50
Secondary liposarcoma of the ovary. (923891)
1977

Expression for genes affiliated with Liposarcoma

About this section
Search GEO for disease gene expression data for Liposarcoma.

Pathways for genes affiliated with Liposarcoma

About this section

Pathways related to Liposarcoma according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MDM2, CDK4
29.9CDK4, MDM2
39.7MDM2, RB1
49.7CDK4, RB1
59.6EWSR1, HMGA2, FUS
6
Show member pathways
9.4RB1, MDM2, CDK4
7
Show member pathways
9.4MDM2, RB1, CDK4
89.4CDK4, MDM2, RB1
9
Show member pathways
9.4CDK4, RB1, MDM2
10
Show member pathways
9.4RB1, MDM2, CDK4
11
Show member pathways
Signaling Pathways in Glioblastoma36
9.4MDM2, RB1, CDK4
12
Show member pathways
Cell cycle36
9.4CDK4, RB1, MDM2
13
Show member pathways
DNA damage response36
9.4CDK4, RB1, MDM2
14
Show member pathways
9.4MDM2, CDK4, RB1
159.4RB1, MDM2, CDK4
169.4RB1, MDM2, CDK4
179.4RB1, MDM2, CDK4
189.3PPARG, RB1, MDM2
199.2ATF1, RB1, CDK4
20
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
9.2CDK4, RB1, ATF1
21
Show member pathways
9.1HMGA2, RB1, CDK4, MDM2
22
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
8.9ATF1, RB1, MDM2, CDK4
238.9MDM2, CDK4, ATF1, RB1
24
Show member pathways
8.6CDK4, KIT, RB1, MDM2
25
Show member pathways
8.5KIT, PPARG, MDM2, RB1
268.3EWSR1, HMGA2, FUS, ATF1, MDM2, PPARG
278.2CDK4, MDM2, RB1, PPARG, KIT
28
Show member pathways
7.7DES, CDK4, MDM2, RB1, KIT, ATF1

Compounds for genes affiliated with Liposarcoma

About this section

Compounds related to Liposarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1roscovitine449.7CDK4, MDM2, RB1
2benzo(a)pyrene449.7CDK4, MDM2, RB1
3carboplatin44 50 1111.6CDK4, RB1, MDM2
4adpribose449.5RB1, MDM2, CDK4, DES
5thymidylate449.4CDK4, MDM2, RB1
6resveratrol44 60 24 1112.4CDK4, PPARG, MDM2, RB1
7trastuzumab44 50 1111.4CDK4, MDM2, KIT
8gefitinib44 50 1111.3MDM2, KIT, CDK4
9estradiol44 24 1111.3CDK4, RB1, MDM2, DES
10geldanamycin44 50 60 1112.3KIT, CDK4, MDM2
11ly294002449.2PPARG, RB1, MDM2, CDK4
12lovastatin44 50 60 28 1113.2CDK4, RB1, LRP1
1312-o-tetradecanoylphorbol 13-acetate449.2DES, CDK4, RB1, ATF1
14genistein44 28 60 1 24 1114.2PPARG, RB1, CDK4, MDM2
15lead449.1CDK4, MDM2, KIT
16sb 20358044 6010.1CDK4, RB1, ATF1, PPARG
17zinc44 2410.1EWSR1, CDK4, MDM2, FUS, RB1
18flavopiridol44 1110.0RB1, MDM2, KIT, CDK4
19p003449.0KIT, MDM2, RB1
20p002449.0MDM2, RB1, KIT, DES
21iron44 249.9CDK4, MDM2, LEPREL1, DES
225fluorouracil448.9CDK4, KIT, RB1, MDM2
23paclitaxel44 50 1110.9KIT, CDK4, RB1, MDM2
24vincristine44 50 1110.8MDM2, RB1, KIT
25lysine448.8MDM2, DES, LRP1, RB1
26dexamethasone44 50 28 1111.7CDK4, PPARG, LRP1, RB1, MDM2
27actinomycin d448.7MDM2, KIT, DES, HMGA2, RB1
28thymidine44 249.6DES, KIT, RB1, MDM2, CDK4
29cyclic amp44 249.6DES, ATF1, EWSR1, RB1, MDM2, CDK4
30rapamycin448.6PPARG, KIT, CDK4, RB1, MDM2
31glycogen44 249.5DES, MDM2, KIT, LRP1, CDK4
32pd 98,059448.5KIT, RB1, ATF1, MDM2, CDK4
33doxorubicin44 50 1110.4HMGA2, KIT, CDK4, MDM2, RB1, DES
34phosphatidylinositol448.2LRP1, KIT, RB1, MDM2, CDK4
35testosterone44 60 24 1111.2MDM2, CDK4, KIT, RB1, PPARG, DES
36estrogen448.2CDK4, MDM2, RB1, KIT, PPARG, DES
37progesterone44 28 60 24 1112.1ATF1, CDK4, MDM2, KIT, DES, RB1
38steroid448.1DES, KIT, CDK4, MDM2, ATF1, RB1
39paraffin448.0RB1, DES, EWSR1, KIT, HMGA2, CDK4
40nitric oxide44 24 1110.0MDM2, RB1, LRP1, CDK4, DES, KIT
41threonine448.0CDK4, MDM2, RB1, LRP1, KIT, DES
42cysteine448.0DES, RB1, KIT, LRP1, MDM2, CDK4
43leucine447.9RB1, ATF1, CDK4, LRP1, KIT, FUS
44vegf447.6LRP1, DES, PPARG, CDK4, KIT, RB1
45tyrosine447.6LRP1, DES, EWSR1, CDK4, MDM2, KIT
46oligonucleotide447.5CDK4, MDM2, KIT, EWSR1, LRP1, ATF1
47glucose447.4PPARG, DES, CDK4, RB1, KIT, LRP1
48retinoic acid44 248.3PPARG, HMGA2, DES, LRP1, EWSR1, KIT
49serine447.1ATF1, CDK4, DES, MDM2, RB1, KIT
50calcium44 50 24 1110.1KIT, RB1, DES, MDM2, ATF1, LRP1

GO Terms for genes affiliated with Liposarcoma

About this section

Cellular components related to Liposarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00056547.6CDK4, PPARG, ATF1, FUS, HMGA2, RB1
2nucleusGO:00056346.9ATF1, LRP1, FUS, EWSR1, HMGA2, RB1

Biological processes related to Liposarcoma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:007115710.1CDK4, MDM2
2lipoprotein transportGO:00429539.7PPARG, LRP1
3stem cell differentiationGO:00488639.5HMGA2, KIT
4response to drugGO:00424939.4CDK4, MDM2, PPARG
5digestive tract developmentGO:00485659.3KIT, RB1
6somatic stem cell maintenanceGO:00350199.3HMGA2, KIT
7negative regulation of transcription, DNA-templatedGO:00458929.3MDM2, RB1, HMGA2, PPARG
8positive regulation of gene expressionGO:00106289.2MDM2, HMGA2, KIT
9positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.2HMGA2, KIT, PPARG
10positive regulation of transcription from RNA polymerase II promoterGO:00459448.8PPARG, ATF1, HMGA2, RB1
11neurotrophin TRK receptor signaling pathwayGO:00480118.5ATF1, KIT, MDM2
12innate immune responseGO:00450878.5MDM2, KIT, ATF1, PPARG

Molecular functions related to Liposarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.5MDM2, HMGA2, PPARG
2core promoter bindingGO:00010479.4HMGA2, RB1
3protein complex bindingGO:00324038.9CDK4, LRP1, ATF1
4identical protein bindingGO:00428028.7DES, FUS, EWSR1, RB1, MDM2
5protein bindingGO:00055155.8CDK4, PPARG, DES, ATF1, LRP1, FUS

Sources for Liposarcoma

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet