Aliases & Classifications for Liposarcoma

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Liposarcoma, Aliases & Descriptions:

Name: Liposarcoma 9 41 11 43 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 47 
Rare tumors


Characteristics (Orphanet epidemiological data):

47
liposarcoma:
Prevalence: 1-9/100000 (Europe); Age of onset: All ages


External Ids:

Disease Ontology9 DOID:3382
MeSH33 D008080
NCIt38 C3194
Orphanet47 69078
MESH via Orphanet34 D008080
ICD10 via Orphanet26 C49
UMLS via Orphanet61 C0023827

Summaries for Liposarcoma

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NIH Rare Diseases:41 Liposarcoma is a tumor that arises from fat tissue.  this tumor often occurs in the thigh, behind the knee, or in the abdomen, but it can be found in other parts of the body.  because a liposarcoma may grow into surrounding tissues or organs, it is considered a malignant tumor. last updated: 2/18/2011

MalaCards based summary: Liposarcoma is related to pleomorphic liposarcoma and myxoid liposarcoma, and has symptoms including abnormality of the skin, sarcoma and abnormality of the urinary system. An important gene associated with Liposarcoma is FUS (fused in sarcoma), and among its related pathways are DNA damage ATM ATR regulation of G1 S checkpoint and Oncogene Induced Senescence. The compounds roscovitine and benzo(a)pyrene have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and lung, and related mouse phenotypes are limbs/digits/tail and adipose tissue.

Disease Ontology:9 A lipomatous cancer that arises in fat cells in deep soft tissue retroperitoneum.

Wikipedia:63 Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the... more...

Related Diseases for Liposarcoma

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Diseases in the Liposarcoma family:

Inflammatory Liposarcoma Adult Liposarcoma

Diseases related to Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1pleomorphic liposarcoma31.7KIT, MDM2
2myxoid liposarcoma31.4ATF1, FUS, EWSR1, MDM2, CDK4
3lipoma31.0DES, FUS, HMGA2, MDM2, CDK4
4dedifferentiated liposarcoma30.9CDK4, MDM2, RB1, HMGA2, KIT, DES
5fibrous histiocytoma30.8DES, ATF1, FUS
6angiomyolipoma30.7KIT, DES
7hemangiopericytoma30.5MDM2, DES
8li-fraumeni syndrome30.4MDM2, RB1
9desmoplastic small round cell tumor30.3EWSR1, DES
10leiomyoma30.2HMGA2, KIT, DES
11desmoid disease, hereditary30.2DES, KIT
12leiomyosarcoma30.2DES, KIT, RB1, MDM2, CDK4
13dermatofibrosarcoma protuberans30.2KIT, DES
14pleomorphic adenoma30.1MDM2, HMGA2, DES
15malignant peripheral nerve sheath tumor30.1KIT, MDM2
16rhabdomyosarcoma30.0DES, EWSR1, RB1, MDM2, CDK4
17adenoma29.9PPARG, HMGA2, RB1, CDK4
18b-cell lymphomas29.8HMGA2, RB1, MDM2, CDK4
19adenocarcinoma29.8CDK4, MDM2, RB1, HMGA2
20retinoblastoma29.7PPARG, RB1, MDM2, CDK4
21clear cell sarcoma29.6ATF1, FUS, EWSR1, KIT
22colorectal cancer29.6PPARG, RB1, MDM2, CDK4
23chondrosarcoma29.5DES, FUS, EWSR1, HMGA2, MDM2, CDK4
24sarcoma29.5EWSR1, FUS, ATF1, DES, KIT, HMGA2
25prostate cancer29.4LRP1, RB1, CDK4
26leukemia29.2ATF1, FUS, EWSR1, KIT, HMGA2, RB1
27melanoma28.6DES, ATF1, LRP1, EWSR1, KIT, RB1
28breast cancer28.3PPARG, ATF1, LRP1, KIT, HMGA2, RB1
29retroperitoneal liposarcoma11.0
30mediastinitis10.6
31myxoid/round cell liposarcoma10.5
32chondroma10.5HMGA2
33atypical lipomatous tumor10.5
34spindle cell liposarcoma10.5
35adenosarcoma10.5DES
36giant cell glioblastoma10.5MDM2
37gliosarcoma10.4CDK4
38myelofibrosis10.4HMGA2
39carney triad10.4KIT
40histiocytoma10.4
41inflammatory liposarcoma10.4
42connective tissue benign neoplasm10.4CDK4, MDM2
43liposarcoma of bone10.3
44anaplastic oligodendroglioma10.3CDK4, MDM2
45gastric liposarcoma10.3
46liposarcoma of the ovary10.3
47myxoid liposarcoma of the ovary10.3
48mixed liposarcoma10.3
49breast liposarcoma10.3
50retinoblastoma fa - friedreich ataxia10.3RB1, MDM2

Graphical network of the top 20 diseases related to Liposarcoma:



Diseases related to liposarcoma

Symptoms for Liposarcoma

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Symptoms:

 47
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • acute abdominal pain/colic
  • intestinal transit disorder
  • functional anomalies of the kidney and the urinary tract
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Liposarcoma:

(show all 6)
id Description Frequency HPO Source Accession
1 abnormality of the skin hallmark (90%) HP:0000951
2 sarcoma hallmark (90%) HP:0100242
3 abnormality of the urinary system occasional (7.5%) HP:0000079
4 abdominal pain occasional (7.5%) HP:0002027
5 abnormality of the intestine occasional (7.5%) HP:0002242
6 neoplasm of the lung occasional (7.5%) HP:0100526

Drugs & Therapeutics for Liposarcoma

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Drug clinical trials:

Search ClinicalTrials for Liposarcoma

Search NIH Clinical Center for Liposarcoma

Genetic Tests for Liposarcoma

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Anatomical Context for Liposarcoma

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MalaCards organs/tissues related to Liposarcoma:

31
Bone, Breast, Lung, Colon, Liver, Adipocyte, Kidney, Heart, Thyroid, Skin, Ovary, Prostate, Tongue, Bone marrow, Smooth muscle, Pancreas, Uterus, Testes, Myeloid, B cells, Lymph node, Spleen, Small intestine, Salivary gland, Adrenal gland, Testis, Appendix

Animal Models for Liposarcoma or affiliated genes

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MGI Mouse Phenotypes related to Liposarcoma:

35 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.6MDM2, RB1, HMGA2, KIT
2MP:00053758.5PPARG, LRP1, EWSR1, HMGA2, RB1
3MP:00053778.4RB1, HMGA2, KIT, PPARG
4MP:00053678.3PPARG, EWSR1, KIT, MDM2, CDK4
5MP:00030128.2PPARG, FUS, KIT, RB1, MDM2
6MP:00020068.1PPARG, EWSR1, KIT, RB1, MDM2, CDK4
7MP:00053797.9PPARG, FUS, EWSR1, KIT, HMGA2, RB1
8MP:00107717.8PPARG, EWSR1, KIT, HMGA2, RB1, MDM2
9MP:00053707.8PPARG, LRP1, KIT, RB1, MDM2, CDK4
10MP:00053907.6PPARG, LRP1, EWSR1, KIT, RB1, MDM2
11MP:00053857.4PPARG, DES, LRP1, KIT, RB1, MDM2
12MP:00053807.3PPARG, ATF1, LRP1, KIT, RB1, MDM2
13MP:00053847.2PPARG, ATF1, FUS, EWSR1, KIT, RB1
14MP:00028737.2PPARG, ATF1, LRP1, EWSR1, KIT, RB1
15MP:00053697.2PPARG, DES, LRP1, EWSR1, KIT, RB1
16MP:00053977.2PPARG, LRP1, FUS, EWSR1, KIT, RB1
17MP:00053867.0PPARG, DES, LRP1, FUS, KIT, HMGA2
18MP:00053897.0CDK4, PPARG, LRP1, FUS, EWSR1, KIT
19MP:00053786.9PPARG, LRP1, FUS, EWSR1, KIT, HMGA2
20MP:00053766.9PPARG, DES, LRP1, KIT, HMGA2, RB1
21MP:00036316.8PPARG, ATF1, LRP1, FUS, KIT, HMGA2
22MP:00053876.7PPARG, ATF1, LRP1, FUS, EWSR1, KIT
23MP:00107686.4PPARG, DES, ATF1, LRP1, FUS, EWSR1

Publications for Liposarcoma

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Articles related to Liposarcoma:

(show top 50)    (show all 1084)
idTitleAuthorsYear
1
Deregulation of dicer and mir-155 expression in liposarcoma. (25888631)
2015
2
Extensive lipoma-like changes of myxoid liposarcoma: morphologic, immunohistochemical, and molecular cytogenetic analyses. (25650275)
2015
3
Giant retroperitoneal liposarcoma during pregnancy: a case report. (25886056)
2015
4
Retroperitoneal perirenal myxoid liposarcoma. (25750026)
2015
5
Primary dedifferentiated liposarcoma of the lung with rhabdomyoblastic and chrondroblastic differentiation. (24612243)
2014
6
Nuclear Expression of STAT6 in Dedifferentiated Liposarcomas With a Solitary Fibrous Tumor-like Morphology: A Diagnostic Pitfall. (25075469)
2014
7
Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma. (24788530)
2014
8
Estrogen receptor alpha and androgen receptor are commonly expressed in well-differentiated liposarcoma. (25349530)
2014
9
Cyclin-dependent kinase inhibitor 2A (p16) distinguishes well-differentiated liposarcoma from lipoma. (23600700)
2013
10
Palmar well differentiated spindle cell liposarcoma: presentation of a rare tumor at a rare site. (23413865)
2013
11
A mediastinal liposarcoma resected using a double approach with a thoracoscope. (25360414)
2013
12
Spermatic cord liposarcoma: organ-sparing surgery. (23814206)
2013
13
Huge mesenteric liposarcoma. (23901685)
2013
14
Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma. (23393200)
2013
15
Dedifferentiated liposarcoma of the retroperitoneum with osteosarcomatous component. (23426961)
2013
16
Lipoma or liposarcoma? A cautionary case report. (21865105)
2012
17
A huge retroperitoneal liposarcoma presenting as a hepatic space-occupying lesion: a case report. (22257481)
2012
18
Malignant nature of cardiac liposarcoma revealed by fluorine-18 fluorodeoxyglucose positron emission tomographic imaging. (22687843)
2012
19
Dedifferentiated subserosal liposarcoma of the jejunum: sonographic and computed tomographic findings with pathologic correlation. (22726982)
2012
20
The well-differentiated liposarcoma of the hypopharynx. (21602115)
2011
21
Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis. (21335544)
2011
22
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
23
Successful thoracoscopic resection of a large mediastinal liposarcoma. (21958801)
2011
24
Giant liposarcoma of the esophagus with Li-Fraumeni-like syndrome. (21454085)
2011
25
Composite reconstruction with cryopreserved fascia lata, single mandibular titanium plate, and polyglactin mesh after redo surgery and radiation therapy for recurrent chest wall liposarcoma. (20674942)
2011
26
Myxoid liposarcoma with EWS-CHOP type 1 fusion gene. (21115923)
2010
27
Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature. (20604797)
2010
28
Liposarcoma of the spermatic cord: a diagnostic dilemma. (21234112)
2010
29
Liposarcoma: exploration of clinical prognostic factors for risk based stratification of therapy. (19558664)
2009
30
Effects of nutritional antioxidants on AAPH- or AGEs-induced oxidative stress in human SW872 liposarcoma cells. (19152116)
2009
31
Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue. (18269578)
2008
32
Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. (16849546)
2006
33
MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. (16160477)
2005
34
Inguinal dedifferentiated liposarcoma with meningothelial-like whorls and metaplastic bone formation. (15842647)
2005
35
Radiology: radiology quiz case 2. Atypical lipomatous tumor, a variant of well-differentiated liposarcoma. (12525210)
2003
36
The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma. (10755400)
2000
37
Biochemical uncovering of mdm2/p53 complexes in liposarcomas parallels their immunohistochemical detection. (10565683)
1999
38
Distinct mdm2/p53 expression patterns in liposarcoma subgroups: implications for different pathogenetic mechanisms. (9071998)
1997
39
Complexity of 12q13-22 amplicon in liposarcoma: microsatellite repeat analysis. (8993982)
1997
40
Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction. (9311018)
1997
41
Gastric liposarcoma: CT appearance. (8508081)
1993
42
Paradoxical cerebral embolism originating from thrombus in tumour veins as presenting manifestation of retroperitoneal liposarcoma. (8461249)
1993
43
Divergent myosarcomatous differentiation in retroperitoneal liposarcoma. (8333554)
1993
44
General case of the day. Myxoid liposarcoma. (2028068)
1991
45
Chromosomal evolution and tumor progression in a myxoid liposarcoma. (2193480)
1990
46
A complex translocation involving chromosomes 12 and 16 in a metastatic myxoid liposarcoma. (3395986)
1988
47
Case profile: computed tomography in retroperitoneal liposarcoma. (6868241)
1983
48
Crystalline inculsion in myxoid liposarcoma. (7282368)
1981
49
Ultrasonography and computed tomography of retroperitoneal liposarcoma. (7273837)
1981
50
Secondary liposarcoma of the ovary. (923891)
1977

Expression for genes affiliated with Liposarcoma

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Search GEO for disease gene expression data for Liposarcoma.

Pathways for genes affiliated with Liposarcoma

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Pathways related to Liposarcoma according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CDK4, MDM2
29.9CDK4, MDM2
39.7MDM2, RB1
49.7CDK4, RB1
59.6FUS, EWSR1, HMGA2
6
Show member pathways
9.4CDK4, MDM2, RB1
7
Show member pathways
9.4CDK4, MDM2, RB1
89.4CDK4, MDM2, RB1
9
Show member pathways
9.4RB1, MDM2, CDK4
10
Show member pathways
9.4CDK4, MDM2, RB1
11
Show member pathways
Signaling Pathways in Glioblastoma36
9.4RB1, MDM2, CDK4
12
Show member pathways
Cell cycle36
9.4RB1, MDM2, CDK4
13
Show member pathways
DNA damage response36
9.4RB1, MDM2, CDK4
14
Show member pathways
9.4RB1, MDM2, CDK4
159.4CDK4, MDM2, RB1
169.4RB1, MDM2, CDK4
179.4CDK4, MDM2, RB1
189.3MDM2, RB1, PPARG
199.2ATF1, RB1, CDK4
20
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.2ATF1, RB1, CDK4
21
Show member pathways
9.1HMGA2, RB1, MDM2, CDK4
22
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
8.9ATF1, RB1, MDM2, CDK4
238.9CDK4, MDM2, RB1, ATF1
24
Show member pathways
8.6CDK4, MDM2, RB1, KIT
25
Show member pathways
8.5PPARG, KIT, RB1, MDM2
268.3MDM2, HMGA2, EWSR1, FUS, ATF1, PPARG
278.2PPARG, KIT, RB1, MDM2, CDK4
28
Show member pathways
7.7DES, ATF1, KIT, RB1, MDM2, CDK4

Compounds for genes affiliated with Liposarcoma

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Compounds related to Liposarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1roscovitine439.7RB1, MDM2, CDK4
2benzo(a)pyrene439.7CDK4, MDM2, RB1
3carboplatin43 49 1211.6CDK4, MDM2, RB1
4adpribose439.5DES, RB1, MDM2, CDK4
5thymidylate439.4CDK4, MDM2, RB1
6resveratrol43 59 24 1212.4CDK4, MDM2, RB1, PPARG
7trastuzumab43 49 1211.4CDK4, MDM2, KIT
8gefitinib43 49 1211.3CDK4, MDM2, KIT
9estradiol43 24 1211.3DES, RB1, MDM2, CDK4
10geldanamycin43 49 59 1212.3KIT, MDM2, CDK4
11ly294002439.2PPARG, RB1, MDM2, CDK4
12lovastatin43 49 59 28 1213.2LRP1, RB1, CDK4
1312-o-tetradecanoylphorbol 13-acetate439.2DES, ATF1, RB1, CDK4
14genistein43 28 59 2 24 1214.2CDK4, MDM2, RB1, PPARG
15lead439.1KIT, MDM2, CDK4
16sb 20358043 5910.1PPARG, ATF1, RB1, CDK4
17zinc43 2410.1FUS, EWSR1, RB1, MDM2, CDK4
18flavopiridol43 1210.0KIT, RB1, MDM2, CDK4
19p003439.0MDM2, RB1, KIT
20p002439.0MDM2, RB1, KIT, DES
21iron43 249.9DES, LEPREL1, MDM2, CDK4
225fluorouracil438.9CDK4, MDM2, RB1, KIT
23paclitaxel43 49 1210.9CDK4, MDM2, RB1, KIT
24vincristine43 49 1210.8MDM2, RB1, KIT
25lysine438.8MDM2, RB1, LRP1, DES
26dexamethasone43 49 28 1211.7PPARG, LRP1, RB1, MDM2, CDK4
27actinomycin d438.7DES, KIT, HMGA2, RB1, MDM2
28thymidine43 249.6DES, KIT, RB1, MDM2, CDK4
29cyclic amp43 249.6DES, ATF1, EWSR1, RB1, MDM2, CDK4
30rapamycin438.6PPARG, KIT, RB1, MDM2, CDK4
31glycogen43 249.5DES, LRP1, KIT, MDM2, CDK4
32pd 98,059438.5ATF1, KIT, RB1, MDM2, CDK4
33doxorubicin43 49 1210.4DES, KIT, HMGA2, RB1, MDM2, CDK4
34phosphatidylinositol438.2LRP1, KIT, RB1, MDM2, CDK4
35testosterone43 59 24 1211.2PPARG, DES, KIT, RB1, MDM2, CDK4
36estrogen438.2PPARG, DES, KIT, RB1, MDM2, CDK4
37progesterone43 28 59 24 1212.1DES, ATF1, KIT, RB1, MDM2, CDK4
38steroid438.1DES, ATF1, KIT, RB1, MDM2, CDK4
39paraffin438.0CDK4, DES, EWSR1, KIT, HMGA2, RB1
40nitric oxide43 24 1210.0DES, LRP1, KIT, RB1, MDM2, CDK4
41threonine438.0DES, LRP1, KIT, RB1, MDM2, CDK4
42cysteine438.0DES, LRP1, KIT, RB1, MDM2, CDK4
43leucine437.9ATF1, LRP1, FUS, KIT, RB1, CDK4
44vegf437.6PPARG, DES, LRP1, KIT, RB1, MDM2
45tyrosine437.6DES, LRP1, EWSR1, KIT, RB1, MDM2
46oligonucleotide437.5ATF1, LRP1, EWSR1, KIT, RB1, MDM2
47glucose437.4PPARG, DES, ATF1, LRP1, KIT, RB1
48retinoic acid43 248.3PPARG, DES, LRP1, EWSR1, KIT, HMGA2
49serine437.1DES, ATF1, LRP1, EWSR1, KIT, RB1
50calcium43 49 24 1210.1DES, ATF1, LRP1, EWSR1, KIT, RB1

GO Terms for genes affiliated with Liposarcoma

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Cellular components related to Liposarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00056547.6CDK4, PPARG, ATF1, FUS, HMGA2, RB1
2nucleusGO:00056346.9ATF1, LRP1, FUS, EWSR1, HMGA2, RB1

Biological processes related to Liposarcoma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:007115710.1CDK4, MDM2
2lipoprotein transportGO:00429539.7PPARG, LRP1
3stem cell differentiationGO:00488639.5HMGA2, KIT
4response to drugGO:00424939.4CDK4, MDM2, PPARG
5digestive tract developmentGO:00485659.3KIT, RB1
6somatic stem cell maintenanceGO:00350199.3HMGA2, KIT
7negative regulation of transcription, DNA-templatedGO:00458929.3MDM2, RB1, HMGA2, PPARG
8positive regulation of gene expressionGO:00106289.2MDM2, HMGA2, KIT
9positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.2HMGA2, KIT, PPARG
10positive regulation of transcription from RNA polymerase II promoterGO:00459448.8PPARG, ATF1, HMGA2, RB1
11neurotrophin TRK receptor signaling pathwayGO:00480118.5ATF1, KIT, MDM2
12innate immune responseGO:00450878.5MDM2, KIT, ATF1, PPARG

Molecular functions related to Liposarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.5MDM2, HMGA2, PPARG
2core promoter bindingGO:00010479.4HMGA2, RB1
3protein complex bindingGO:00324038.9CDK4, LRP1, ATF1
4identical protein bindingGO:00428028.7DES, FUS, EWSR1, RB1, MDM2
5protein bindingGO:00055155.8CDK4, PPARG, DES, ATF1, LRP1, FUS

Products for genes affiliated with Liposarcoma

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Sources for Liposarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet