MCID: LPS002
MIFTS: 60

Liposarcoma malady

Summaries for Liposarcoma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Liposarcoma is a tumor that arises from fat tissue.  this tumor often occurs in the thigh, behind the knee, or in the abdomen, but it can be found in other parts of the body.  because a liposarcoma may grow into surrounding tissues or organs, it is considered a malignant tumor. last updated: 2/18/2011

MalaCards: Liposarcoma, also known as liposarcoma nos, is related to myxoid liposarcoma and pleomorphic liposarcoma. An important gene associated with Liposarcoma is LPSA (Oncogene liposarcoma (DNA segment, single copy, expressed, probes), and among its related pathways are Rho Family GTPases and Transcriptional misregulation in cancer. The compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and adipocyte, and related mouse phenotypes are behavior/neurological and immune system.

Disease Ontology:8 A malignant lipomatous neoplasm that arises in fat cells in deep soft tissue retroperitoneum.

Wikipedia:63 Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the... more...

Aliases & Classifications for Liposarcoma

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8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

liposarcoma 8 42 46 10 44 60
liposarcoma nos 8


External Ids:

Disease Ontology8 DOID:3382
NCIt39 C3194
MeSH34 D008080

Related Diseases for Liposarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Liposarcoma family:

Adult Liposarcoma Inflammatory Liposarcoma

Diseases related to Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1myxoid liposarcoma31.5DDIT3, ATF1
2pleomorphic liposarcoma31.1MDM2, KIT
3lipoma30.9HMGA2, CDK4, DES, DDIT3, MDM2, FUS
4sarcoma30.7FUS, HMGA2, KIT, YBX1, CDK4, DES
5fibrous histiocytoma30.5FUS, DES, ATF1, VIM
6leiomyosarcoma30.4VIM, CALB2, MVP, MDM2, RB1, DES
7fibrosarcoma30.3VIM, MVP, MDM2, DES
8leukemia30.2MVP, EWSR1, MDM2, RB1, DDIT3, ATF1
9osteosarcoma30.2MVP, MDM2, RB1, DDIT3, CDK4, YBX1
10acute leukemia30.2KIT, EWSR1, MVP
11angiomyolipoma30.1VIM, DES, KIT
12melanoma30.0MDM2, EWSR1, MVP, CALB2, VIM, RB1
13rhabdomyosarcoma30.0RB1, MDM2, EWSR1, MVP, CALB2, VIM
14dedifferentiated liposarcoma30.0MDM2, HMGA2, KIT, CDK4, DES, RB1
15adenocarcinoma29.9VIM, CALB2, MVP, MDM2, RB1, CDK4
16adenoma29.9CALB2, PPARG, RB1, CDK4, HMGA2
17leiomyoma29.9VIM, DES, KIT, HMGA2
18hemangiopericytoma29.9VIM, MDM2, DES
19myeloid leukemia29.9CDK4, KIT
20pleomorphic adenoma29.9HMGA2
21chondrosarcoma29.7HMGA2, CDK4, DES, DDIT3, MDM2, EWSR1
22prostate cancer29.7MDM2, RB1, DDIT3, POLR2L, CDK4, YBX1
23synovial sarcoma29.7VIM, CALB2, MDM2, DES, KIT, HMGA2
24retinoblastoma29.7PPARG, MDM2, RB1, POLR2L, CDK4
25colorectal cancer29.7LRP1, CDK4, RB1, MDM2, PPARG, MVP
26ovarian cancer29.7YBX1, CDK4, DDIT3, MDM2, MVP, CALB2
27clear cell sarcoma29.7FUS, EWSR1, ATF1, KIT
28malignant peripheral nerve sheath tumor29.7VIM, CALB2, MDM2, KIT
29breast cancer29.7VIM, MVP, MDM2, RB1, CDK4, YBX1
30dermatofibrosarcoma protuberans29.7KIT, DES, VIM
31desmoid tumor29.7DES, KIT
32desmoplastic small round cell tumor29.7EWSR1, DES
33amyotrophic lateral sclerosis29.7FUS, CALB2
34epithelioid sarcoma29.7VIM, CALB2
35paraganglioma29.7KIT
36mediastinitis10.5
37mediastinum liposarcoma10.5
38spindle cell liposarcoma10.5
39inflammatory liposarcoma10.5
40atypical lipomatous tumor10.4
41breast liposarcoma10.4
42mixed-type liposarcoma10.4
43liposarcoma of bone10.4
44esophagus liposarcoma10.3
45histiocytoma10.3
46adult liposarcoma10.3
47larynx liposarcoma10.3
48gastric liposarcoma10.3
49sclerosing liposarcoma10.3
50retroperitoneal liposarcoma10.3

Graphical network of the top 20 diseases related to Liposarcoma:



Diseases related to liposarcoma

Clinical Features for Liposarcoma

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Drugs & Therapeutics for Liposarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Liposarcoma

Drug clinical trials:

Search ClinicalTrials for Liposarcoma

Search NIH Clinical Center for Liposarcoma

Search CenterWatch for Liposarcoma

Genetic Tests for Liposarcoma

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Anatomical Context for Liposarcoma

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32MalaCards
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MalaCards organs/tissues related to Liposarcoma:

32
Bone, Breast, Adipocyte, Liver, Heart, Colon, Thyroid, Lung, Tongue, Prostate, Kidney, Myeloid, B cells, Testes, Uterus, Ovary, Bone marrow, Pancreas, Smooth muscle, Adrenal gland, Salivary gland, Testis, Small intestine, Lymph node, Appendix

Animal Models for Liposarcoma or affiliated genes

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36MGI
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Publications for Liposarcoma

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50PubMed
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Articles related to Liposarcoma:

(show top 50)    (show all 995)
idTitleAuthorsYear
1
High level of CDK4 amplification is a poor prognostic factor in well-differentiated and dedifferentiated liposarcoma. (23852861)
2013
2
Liposarcoma of the head and neck: Analysis of 318 cases with comparison to non-head and neck sites. (23728920)
2013
3
Paratesticular liposarcoma: a case report and review of the literature. (23533935)
2013
4
Paratesticular liposarcoma: unusual patterns of recurrence and importance of margins. (23591942)
2013
5
Deep-seated huge hibernoma of soft tissue: a rare differential diagnosis of atypical lipomatous tumor/well differentiated liposarcoma. (24133596)
2013
6
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study. (23084521)
2012
7
Update on liposarcoma: a review for cytopathologists. (21932353)
2012
8
Pathology in practice. Widespread, metastatic liposarcoma and moderate, acute, diffuse centrilobular hepatic necrosis. (22309010)
2012
9
Successful resection of a massive mediastinal liposarcoma that rapidly extended into the entire left thoracic cavity: report of a case. (22045230)
2012
10
Primary pleomorphic liposarcoma of breast: a rare case report. (21393893)
2011
11
Let-7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data. (21412931)
2011
12
Retroperitoneal liposarcoma in an adult patient with Down syndrome. (22299213)
2011
13
Can MDM2 analytical tests performed on core needle biopsy be relied upon to diagnose well-differentiated liposarcoma? (20495536)
2010
14
Surgical outcomes for liposarcoma of the lower limbs with synchronous pulmonary metastases. (20872809)
2010
15
Liposarcomas with mixed well-differentiated and pleomorphic features: a clinicopathologic study of 12 cases. (20431480)
2010
16
Synchronous testicular liposarcoma and prostate adenocarcinoma: a case report. (20205765)
2010
17
Dedifferentiated liposarcoma of thigh with chondrosarcomatous dedifferentiated component. (21623423)
2010
18
Novel models of myxoid liposarcoma xenografts mimicking the biological and pharmacologic features of human tumors. (20732964)
2010
19
Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis. (20525266)
2010
20
Lipoleiomyosarcoma of the rectosigmoid colon: a unique site for a rare variant of liposarcoma. (19363435)
2009
21
Silicone implant for chin augmentation mimicking a low-grade liposarcoma. (19327631)
2009
22
Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma. (19820690)
2009
23
Involvement of c-jun in human liposarcoma growth: supporting data from clinical immunohistochemistry and DNAzyme efficacy. (18497564)
2008
24
Primary mediastinal large B-cell lymphoma mimicking liposarcoma. (18066682)
2008
25
High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma. (18414473)
2008
26
Mediastinal pleomorphic liposarcoma diagnosed by fine needle aspiration biopsy: a case report. (17536551)
2007
27
Dermal atypical lipomatous tumor/well-differentiated liposarcoma obfuscated by epidermal inclusion cyst: a wolf in sheep's clothing? (16871039)
2006
28
Inguinal dedifferentiated liposarcoma with meningothelial-like whorls and metaplastic bone formation. (15842647)
2005
29
Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity. (15221942)
2004
30
Pleomorphic liposarcoma of the uterus: case report and literature review. (14501826)
2003
31
Primary dedifferentiated liposarcoma of the retroperitoneum. Prognostic significance of computed tomography and magnetic resonance imaging features. (14501373)
2003
32
Cardiac encasement by metastatic myxoid liposarcoma. (12459432)
2002
33
Analysis of the molecular species generated by MDM2 gene amplification in liposarcomas. (11351297)
2001
34
Monoclonality of multifocal myxoid liposarcoma: confirmation by analysis of TLS-CHOP or EWS-CHOP rearrangements. (10914725)
2000
35
Dedifferentiated liposarcoma with chondroblastic osteosarcomatous dedifferentiation. (10886740)
2000
36
The patho-morphology and biological behavior of repeatedly recurrent liposarcoma in retroperitoneum]. (11869504)
1999
37
Demonstration of recurrent dedifferentiated liposarcoma of the spermatic cord by FDG-PET. (9310177)
1997
38
Myxoid liposarcoma with cartilaginous differentiation. (8685223)
1996
39
Myxoid liposarcoma of the ankle. (8590881)
1995
40
Enhanced expression of catalytic subunits of protein phosphatase type 1 and high S-phase fraction in liposarcoma. (7827812)
1994
41
Isolation of a somatic cell hybrid retaining the der(16)t(12;16)(q13;p11.2) from a myxoid liposarcoma cell line. (8428517)
1993
42
Translocation t(12;16)(q13;p11) in myxoid liposarcoma of a child and implication of the human int-1 gene in tumorigenesis. (2515180)
1989
43
The human int-1 gene is located at chromosome region 12q12-12q13 and is not rearranged in myxoid liposarcoma with t(12;16) (q13;p11). (3329717)
1987
44
Dedifferentiated liposarcoma of the liver. (3677011)
1987
45
Myxoid liposarcoma of the right atrium. A case report. (3704877)
1986
46
Needle tract seeding following puncture of retroperitoneal liposarcoma. (6653630)
1983
47
Combination chemotherapy in retroperitoneal poorly differentiated myxoid liposarcoma: a report of a case. (6842911)
1983
48
Ultrasonography and computed tomography of retroperitoneal liposarcoma. (7273837)
1981
49
Primary pleomorphic liposarcoma of the larynx. (650725)
1978
50
Retroperitoneal liposarcoma in adult: a case report and review of literature. (13220855)
1954

Genetic Variations for Liposarcoma

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Expression for genes affiliated with Liposarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Liposarcoma

Search GEO for disease gene expression data for Liposarcoma.

Pathways for genes affiliated with Liposarcoma

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore
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Compounds for genes affiliated with Liposarcoma

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Liposarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1vegf4411.3MVP, PPARG, MDM2, RB1, LRP1, YBX1
2retinoic acid44 2412.3POLR2L, HMGA2, KIT, RB1, DES, CDK4
3oligonucleotide4411.3ATF1, KIT, LRP1, YBX1, CDK4, POLR2L
4paraffin4411.2HMGA2, KIT, DES, RB1, MDM2, EWSR1
5doxorubicin44 49 1113.2POLR2L, DES, MDM2, CDK4, YBX1, MVP
6testosterone44 59 11 2414.2KIT, POLR2L, DES, VIM, DDIT3, RB1
7tyrosine4411.2YBX1, EWSR1, MDM2, LRP1, RB1, DDIT3
8leucine4411.2TSN, DDIT3, KIT, LRP1, CDK4, FUS
9progesterone44 59 28 11 2415.2KIT, CALB2, CDK4, MVP, MDM2, ATF1
10actinomycin d4411.2HMGA2, DDIT3, VIM, MDM2, DES, POLR2L
11cisplatin44 49 59 1114.1DDIT3, HMGA2, RB1, MDM2, MVP, CDK4
12paclitaxel44 49 1113.1MDM2, YBX1, MVP, CALB2, CDK4, RB1
13steroid4411.1YBX1, RB1, DES, ATF1, CDK4, MDM2
14nitric oxide44 11 2413.1RB1, CALB2, DES, KIT, CDK4, LRP1
15thymidylate4411.1CDK4, RB1, MDM2, MVP, VIM, POLR2L
16vincristine44 49 1113.1RB1, VIM, MVP, MDM2, KIT, YBX1
17lysine4411.1MDM2, YBX1, LRP1, POLR2L, DES, RB1
18threonine4411.1YBX1, LRP1, CDK4, POLR2L, DES, RB1
19camptothecin44 59 1113.1POLR2L, MVP, MDM2, RB1, CDK4, YBX1
205fluorouracil4411.1MVP, YBX1, KIT, CDK4, RB1, MDM2
21cyclic amp44 2412.1MDM2, EWSR1, VIM, CDK4, DES, ATF1
22roscovitine4411.0POLR2L, CDK4, VIM, RB1, MDM2
23flavopiridol44 1112.0POLR2L, MDM2, CDK4, KIT, RB1
24sb 20358044 5912.0RB1, PPARG, VIM, DDIT3, ATF1, CDK4
25etoposide44 49 59 1114.0RB1, DDIT3, MDM2, MVP, VIM, YBX1
26serine4411.0YBX1, POLR2L, EWSR1, ATF1, DES
27cysteine4411.0KIT, VIM, MDM2, RB1, DES, POLR2L
28p0024411.0DES, KIT, MDM2, RB1, MVP
29atp44 2812.0KIT, DDIT3, VIM, MVP, RB1, POLR2L
30rapamycin4411.0PPARG, MDM2, RB1, CDK4, KIT, VIM
31adriamycin4411.0MVP, VIM, DES, RB1, MDM2
32glycogen44 2412.0MDM2, VIM, CDK4, DES, LRP1, KIT
33bromodeoxyuridine4411.0DES, RB1, VIM, CDK4, DDIT3
34estrogen4411.0CALB2, MVP
35formaldehyde44 2411.9DES, RB1, POLR2L, KIT, VIM
36n-(4-hydroxyphenyl)retinamide4410.9CDK4, VIM, DDIT3, RB1
37genistein44 28 59 2 11 2415.9VIM, PPARG, MDM2, DDIT3, CDK4, RB1
38butyrate4410.9CALB2
39iron44 2411.9VIM, DES, MDM2, DDIT3, LEPREL1, CDK4
40hematoxylin4410.9KIT, CALB2, VIM, DES
41glucose4410.8LRP1, DDIT3, PPARG
42dexamethasone44 49 28 1113.8MDM2, RB1, CDK4, POLR2L
43toluidine4410.8DES, VIM, KIT
44carboplatin44 49 1112.7RB1, MDM2, DDIT3, CDK4
45mucicarmine4410.7DES, CALB2, VIM
46zinc44 2411.7RB1, POLR2L, CDK4, FUS, CALB2, EWSR1
47gefitinib44 49 1112.7VIM, CDK4, KIT, MDM2
48agar4410.6CDK4, RB1, VIM, YBX1, MDM2
49retinoid4410.5CDK4, POLR2L, VIM, PPARG, DDIT3
50arginine4410.4YBX1, CDK4, VIM, EWSR1, MDM2, DES

GO Terms for genes affiliated with Liposarcoma

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16Gene Ontology
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Cellular components related to Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565410.7FUS, PPARG, MDM2, RB1, DDIT3, ATF1
2nucleusGO:00563410.7DDIT3, RB1, MDM2, PPARG, EWSR1, MVP
3extracellular vesicular exosomeGO:07006210.6YBX1, MVP, VIM

Biological processes related to Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.6KIT, POLR2L, ATF1, MDM2, PPARG
2negative regulation of transcription, DNA-dependentGO:04589210.6HMGA2, YBX1, DDIT3, RB1, MDM2, PPARG
3lipoprotein transportGO:04295310.2PPARG, LRP1

Molecular functions related to Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9FUS, VIM, MVP, EWSR1, PPARG, MDM2
2DNA bindingGO:00367710.7RB1, DDIT3, POLR2L, YBX1, HMGA2, TSN
3identical protein bindingGO:04280210.4VIM, EWSR1, MDM2, RB1, DES, FUS

Products for genes affiliated with Liposarcoma

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Sources for Liposarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet