MCID: LPS002
MIFTS: 60

Liposarcoma malady

Summaries for Liposarcoma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Liposarcoma is a tumor that arises from fat tissue.  this tumor often occurs in the thigh, behind the knee, or in the abdomen, but it can be found in other parts of the body.  because a liposarcoma may grow into surrounding tissues or organs, it is considered a malignant tumor. last updated: 2/18/2011

MalaCards: Liposarcoma, also known as liposarcoma nos, is related to myxoid liposarcoma and pleomorphic liposarcoma. An important gene associated with Liposarcoma is LPSA (Oncogene liposarcoma (DNA segment, single copy, expressed, probes), and among its related pathways are Rho Family GTPases and Transcriptional misregulation in cancer. The compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and adipocyte, and related mouse phenotypes are behavior/neurological and immune system.

Disease Ontology:8 A malignant lipomatous neoplasm that arises in fat cells in deep soft tissue retroperitoneum.

Wikipedia:63 Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the... more...

Aliases & Classifications for Liposarcoma

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8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

liposarcoma 8 42 46 10 44 60
liposarcoma nos 8


External Ids:

Disease Ontology8 DOID:3382
NCIt39 C3194
MeSH34 D008080

Related Diseases for Liposarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Liposarcoma family:

Adult Liposarcoma Inflammatory Liposarcoma

Diseases related to Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1myxoid liposarcoma31.5DDIT3, ATF1
2pleomorphic liposarcoma31.1MDM2, KIT
3lipoma30.9HMGA2, CDK4, DES, DDIT3, MDM2, FUS
4sarcoma30.7FUS, HMGA2, KIT, YBX1, CDK4, DES
5fibrous histiocytoma30.5FUS, DES, ATF1, VIM
6leiomyosarcoma30.4VIM, CALB2, MVP, MDM2, RB1, DES
7fibrosarcoma30.3VIM, MVP, MDM2, DES
8leukemia30.2MVP, EWSR1, MDM2, RB1, DDIT3, ATF1
9osteosarcoma30.2MVP, MDM2, RB1, DDIT3, CDK4, YBX1
10acute leukemia30.2KIT, EWSR1, MVP
11angiomyolipoma30.1VIM, DES, KIT
12melanoma30.0MDM2, EWSR1, MVP, CALB2, VIM, RB1
13rhabdomyosarcoma30.0RB1, MDM2, EWSR1, MVP, CALB2, VIM
14dedifferentiated liposarcoma30.0MDM2, HMGA2, KIT, CDK4, DES, RB1
15adenocarcinoma29.9VIM, CALB2, MVP, MDM2, RB1, CDK4
16adenoma29.9CALB2, PPARG, RB1, CDK4, HMGA2
17leiomyoma29.9VIM, DES, KIT, HMGA2
18hemangiopericytoma29.9VIM, MDM2, DES
19myeloid leukemia29.9CDK4, KIT
20pleomorphic adenoma29.9HMGA2
21chondrosarcoma29.7HMGA2, CDK4, DES, DDIT3, MDM2, EWSR1
22prostate cancer29.7MDM2, RB1, DDIT3, POLR2L, CDK4, YBX1
23synovial sarcoma29.7VIM, CALB2, MDM2, DES, KIT, HMGA2
24retinoblastoma29.7PPARG, MDM2, RB1, POLR2L, CDK4
25colorectal cancer29.7LRP1, CDK4, RB1, MDM2, PPARG, MVP
26ovarian cancer29.7YBX1, CDK4, DDIT3, MDM2, MVP, CALB2
27clear cell sarcoma29.7FUS, EWSR1, ATF1, KIT
28malignant peripheral nerve sheath tumor29.7VIM, CALB2, MDM2, KIT
29breast cancer29.7VIM, MVP, MDM2, RB1, CDK4, YBX1
30dermatofibrosarcoma protuberans29.7KIT, DES, VIM
31desmoid tumor29.7DES, KIT
32desmoplastic small round cell tumor29.7EWSR1, DES
33amyotrophic lateral sclerosis29.7FUS, CALB2
34epithelioid sarcoma29.7VIM, CALB2
35paraganglioma29.7KIT
36mediastinitis10.5
37mediastinum liposarcoma10.5
38spindle cell liposarcoma10.5
39inflammatory liposarcoma10.5
40atypical lipomatous tumor10.4
41breast liposarcoma10.4
42mixed-type liposarcoma10.4
43liposarcoma of bone10.4
44esophagus liposarcoma10.3
45histiocytoma10.3
46adult liposarcoma10.3
47larynx liposarcoma10.3
48gastric liposarcoma10.3
49sclerosing liposarcoma10.3
50retroperitoneal liposarcoma10.3

Graphical network of the top 20 diseases related to Liposarcoma:



Diseases related to liposarcoma

Clinical Features for Liposarcoma

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Drugs & Therapeutics for Liposarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Liposarcoma

Drug clinical trials:

Search ClinicalTrials for Liposarcoma

Search NIH Clinical Center for Liposarcoma

Search CenterWatch for Liposarcoma

Genetic Tests for Liposarcoma

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Anatomical Context for Liposarcoma

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32MalaCards
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MalaCards organs/tissues related to Liposarcoma:

32
Bone, Breast, Adipocyte, Liver, Heart, Colon, Thyroid, Lung, Kidney, Tongue, Prostate, Pancreas, Smooth muscle, B cells, Myeloid, Testes, Bone marrow, Ovary, Uterus, Testis, Adrenal gland, Salivary gland, Lymph node, Small intestine, Appendix

Animal Models for Liposarcoma or affiliated genes

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36MGI
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Publications for Liposarcoma

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50PubMed
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Articles related to Liposarcoma:

(show top 50)    (show all 995)
idTitleAuthorsYear
1
Cyclin-dependent kinase inhibitor 2A (p16) distinguishes well-differentiated liposarcoma from lipoma. (23600700)
2013
2
Herbal-drug interaction induced rhabdomyolysis in a liposarcoma patient receiving trabectedin. (23899130)
2013
3
Retroperitoneal Liposarcoma: A Comprehensive Review. (24136142)
2013
4
A case of recurrent mesocolon myxoid liposarcoma and review of the literature. (24312738)
2013
5
Myxoid liposarcoma and the mammalian target of rapamycin pathway. (23673410)
2013
6
Dedifferentiated subserosal liposarcoma of the jejunum: sonographic and computed tomographic findings with pathologic correlation. (22726982)
2012
7
Dedifferentiated liposarcoma of the rectum: a case report. (23139616)
2012
8
Cardiac myxoid liposarcoma metastasis: cardiac magnetic resonance features. (22573904)
2012
9
A huge retroperitoneal liposarcoma: case report. (22873110)
2012
10
Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents. (21805478)
2012
11
Liposarcoma of the spermatic cord: a report of two cases. (22524907)
2012
12
Giant gastric lipoma mimicking well-differentiated liposarcoma. (23308321)
2012
13
Liposarcoma of the spermatic cord: a rare entity. (22606620)
2011
14
Metachronous pleomorphic liposarcoma and melanoma: a rare case report. (21393919)
2011
15
Pedicle omental flap transfer combined with vascular reconstruction after wide resection of a myxoid liposarcoma in the inguinal region. (21835585)
2011
16
Liposarcoma of the retroperitoneum with dedifferentiation to osteosarcoma: a case report. (21467867)
2011
17
Genomic investigation of dedifferentiated liposarcoma suggests a role for therapeutic targeting of the tumor epigenome. (22586679)
2011
18
Giant dedifferentiated retroperitoneal liposarcoma. (21914419)
2011
19
Well-differentiated liposarcoma, an atypical lipomatous tumor, of the mesentery: a case report and review of the literature. (21526137)
2011
20
Liposarcoma of the spermatic cord: a diagnostic dilemma. (21234112)
2010
21
Giant oesophageal liposarcoma mimicking spindle cell liposarcoma and containing eosinophilic cells with rhabdomyoblastic differentiation. (20418237)
2010
22
Epithelioid variant of a pleomorphic liposarcoma displaying arborizing vascular arrangements on cytology smears: a case report of an interesting cytomorphologic pattern in an uncommon tumor. (21053578)
2010
23
Added Value of Molecular Biological Analysis in Diagnosis and Clinical Management of Liposarcoma: A 30-Year Single-Institution Experience. (20183915)
2010
24
Radiosensitivity translates into excellent local control in extremity myxoid liposarcoma: a comparison with other soft tissue sarcomas. (19472403)
2009
25
Two Cases of Retroperitoneal Liposarcoma Diagnosed Using Endoscopic Ultrasound-Guided Fine-Needle Aspiration (EUS-FNA). (19859574)
2009
26
An unusual case of giant primary mediastinal liposarcoma. (19670126)
2009
27
Validation of immature adipogenic status and identification of prognostic biomarkers in myxoid liposarcoma using tissue microarrays. (19368956)
2009
28
FDG-PET Lacks Sufficient Sensitivity to Detect Myxoid Liposarcoma Spinal Metastases Detected by MRI. (17641744)
2007
29
Myxoid liposarcoma: an unusual presentation. (17312073)
2007
30
Retroperitoneal liposarcoma. (17296434)
2007
31
alpha-fetoprotein expression in a dedifferentiated liposarcoma. (16489442)
2006
32
A case representing coexistence of acute myeloblastic leukemia and dedifferentiated liposarcoma: the possible role of chemotherapy in triggering dedifferentiation. (16999727)
2006
33
Spindle-cell liposarcoma: a rare variant of liposarcoma arising in the foot. (15830579)
2005
34
Low-grade pulmonary myxoid liposarcoma. (17670442)
2005
35
Hand-assisted laparoscopic removal of retroperitoneal liposarcoma. (15922434)
2005
36
Well-differentiated liposarcoma associated with benign lipoma. (15154619)
2004
37
A phase II trial with rosiglitazone in liposarcoma patients. (14562008)
2003
38
Images in pathology: multiple cytoplasmic vacuoles in a spindle cell liposarcoma. (12232576)
2002
39
Ectopic sequences from truncated HMGIC in liposarcomas are derived from various amplified chromosomal regions. (11391797)
2001
40
Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;6). (11126370)
2000
41
Retroperitoneal liposarcoma: sonographic findings. (10931998)
2000
42
Massive retroperitoneal liposarcoma. (11037573)
2000
43
Pseudo-crossed renal ectopia secondary to a myxoid liposarcoma. (9836568)
1998
44
Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation. (9060596)
1997
45
Myxoid liposarcoma. (7592290)
1995
46
Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21). (7566973)
1995
47
Chimeric TLS/FUS-CHOP gene expression and the heterogeneity of its junction in human myxoid and round cell liposarcoma. (7485386)
1995
48
Heterologous elements in the dedifferentiated component of dedifferentiated liposarcoma. (7943536)
1994
49
Psuedocrossed renal ectopia secondary to retroperitoneal liposarcoma. (7292831)
1981
50
Embryonal liposarcoma (myxoid liposarcoma): a study of six cases. (5764284)
1969

Genetic Variations for Liposarcoma

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Expression for genes affiliated with Liposarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Liposarcoma

Search GEO for disease gene expression data for Liposarcoma.

Pathways for genes affiliated with Liposarcoma

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore
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Compounds for genes affiliated with Liposarcoma

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Liposarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1vegf4411.3MVP, PPARG, MDM2, RB1, LRP1, YBX1
2retinoic acid44 2412.3POLR2L, HMGA2, KIT, RB1, DES, CDK4
3oligonucleotide4411.3ATF1, KIT, LRP1, YBX1, CDK4, POLR2L
4paraffin4411.2HMGA2, KIT, DES, RB1, MDM2, EWSR1
5doxorubicin44 49 1113.2POLR2L, DES, MDM2, CDK4, YBX1, MVP
6testosterone44 59 11 2414.2KIT, POLR2L, DES, VIM, DDIT3, RB1
7tyrosine4411.2YBX1, EWSR1, MDM2, LRP1, RB1, DDIT3
8leucine4411.2TSN, DDIT3, KIT, LRP1, CDK4, FUS
9progesterone44 59 28 11 2415.2KIT, CALB2, CDK4, MVP, MDM2, ATF1
10actinomycin d4411.2HMGA2, DDIT3, VIM, MDM2, DES, POLR2L
11cisplatin44 49 59 1114.1DDIT3, HMGA2, RB1, MDM2, MVP, CDK4
12paclitaxel44 49 1113.1MDM2, YBX1, MVP, CALB2, CDK4, RB1
13steroid4411.1YBX1, RB1, DES, ATF1, CDK4, MDM2
14nitric oxide44 11 2413.1RB1, CALB2, DES, KIT, CDK4, LRP1
15thymidylate4411.1CDK4, RB1, MDM2, MVP, VIM, POLR2L
16vincristine44 49 1113.1RB1, VIM, MVP, MDM2, KIT, YBX1
17lysine4411.1MDM2, YBX1, LRP1, POLR2L, DES, RB1
18threonine4411.1YBX1, LRP1, CDK4, POLR2L, DES, RB1
19camptothecin44 59 1113.1POLR2L, MVP, MDM2, RB1, CDK4, YBX1
205fluorouracil4411.1MVP, YBX1, KIT, CDK4, RB1, MDM2
21cyclic amp44 2412.1MDM2, EWSR1, VIM, CDK4, DES, ATF1
22roscovitine4411.0POLR2L, CDK4, VIM, RB1, MDM2
23flavopiridol44 1112.0POLR2L, MDM2, CDK4, KIT, RB1
24sb 20358044 5912.0RB1, PPARG, VIM, DDIT3, ATF1, CDK4
25etoposide44 49 59 1114.0RB1, DDIT3, MDM2, MVP, VIM, YBX1
26serine4411.0YBX1, POLR2L, EWSR1, ATF1, DES
27cysteine4411.0KIT, VIM, MDM2, RB1, DES, POLR2L
28p0024411.0DES, KIT, MDM2, RB1, MVP
29atp44 2812.0KIT, DDIT3, VIM, MVP, RB1, POLR2L
30rapamycin4411.0PPARG, MDM2, RB1, CDK4, KIT, VIM
31adriamycin4411.0MVP, VIM, DES, RB1, MDM2
32glycogen44 2412.0MDM2, VIM, CDK4, DES, LRP1, KIT
33bromodeoxyuridine4411.0DES, RB1, VIM, CDK4, DDIT3
34estrogen4411.0CALB2, MVP
35formaldehyde44 2411.9DES, RB1, POLR2L, KIT, VIM
36n-(4-hydroxyphenyl)retinamide4410.9CDK4, VIM, DDIT3, RB1
37genistein44 28 59 2 11 2415.9VIM, PPARG, MDM2, DDIT3, CDK4, RB1
38butyrate4410.9CALB2
39iron44 2411.9VIM, DES, MDM2, DDIT3, LEPREL1, CDK4
40hematoxylin4410.9KIT, CALB2, VIM, DES
41glucose4410.8LRP1, DDIT3, PPARG
42dexamethasone44 49 28 1113.8MDM2, RB1, CDK4, POLR2L
43toluidine4410.8DES, VIM, KIT
44carboplatin44 49 1112.7RB1, MDM2, DDIT3, CDK4
45mucicarmine4410.7DES, CALB2, VIM
46zinc44 2411.7RB1, POLR2L, CDK4, FUS, CALB2, EWSR1
47gefitinib44 49 1112.7VIM, CDK4, KIT, MDM2
48agar4410.6CDK4, RB1, VIM, YBX1, MDM2
49retinoid4410.5CDK4, POLR2L, VIM, PPARG, DDIT3
50arginine4410.4YBX1, CDK4, VIM, EWSR1, MDM2, DES

GO Terms for genes affiliated with Liposarcoma

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16Gene Ontology
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Cellular components related to Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565410.7POLR2L, YBX1, CDK4, ATF1, DDIT3, RB1
2nucleusGO:00563410.7MVP, FUS, EWSR1, PPARG, MDM2, TSN
3extracellular vesicular exosomeGO:07006210.6YBX1, MVP, VIM

Biological processes related to Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.6MDM2, ATF1, POLR2L, KIT, PPARG
2negative regulation of transcription, DNA-dependentGO:04589210.6PPARG, MDM2, RB1, DDIT3, YBX1, HMGA2
3lipoprotein transportGO:04295310.2LRP1, PPARG

Molecular functions related to Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9DES, LRP1, YBX1, CDK4, EWSR1, ATF1
2DNA bindingGO:00367710.7PPARG, RB1, DDIT3, POLR2L, YBX1, HMGA2
3identical protein bindingGO:04280210.4FUS, RB1, MDM2, EWSR1, DES, VIM

Products for genes affiliated with Liposarcoma

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Sources for Liposarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet