MCID: LPS002
MIFTS: 54

Liposarcoma malady

Summaries for Liposarcoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Liposarcoma is a tumor that arises from fat tissue.  this tumor often occurs in the thigh, behind the knee, or in the abdomen, but it can be found in other parts of the body.  because a liposarcoma may grow into surrounding tissues or organs, it is considered a malignant tumor. last updated: 2/18/2011

MalaCards: Liposarcoma, also known as liposarcoma nos, is related to myxoid liposarcoma and dedifferentiated liposarcoma. An important gene associated with Liposarcoma is LPSA (Oncogene liposarcoma (DNA segment, single copy, expressed, probes), and among its related pathways are Rho Family GTPases and Transcriptional misregulation in cancer. The compounds vegf and retinoic acid have been mentioned in the context of this disorder. Related mouse phenotypes are behavior/neurological and immune system.

Disease Ontology:8 A malignant lipomatous neoplasm that arises in fat cells in deep soft tissue retroperitoneum.

Wikipedia:64 Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the... more...

Aliases & Classifications for Liposarcoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

liposarcoma 8 43 47 10 45 61
liposarcoma nos 8


External Ids:

Disease Ontology8 DOID:3382
NCIt40 C3194
MeSH35 D008080

Related Diseases for Liposarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Liposarcoma family:

adult liposarcoma inflammatory liposarcoma

Diseases related to Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 222)
idRelated DiseaseScoreTop Affiliating Genes
1myxoid liposarcoma31.6DDIT3, ATF1
2dedifferentiated liposarcoma31.4HMGA2, MDM2, RB1, DES, KIT, CDK4
3pleomorphic liposarcoma31.2MDM2, KIT
4fibrous histiocytoma30.5VIM, DES, ATF1, FUS
5acute leukemia30.3KIT, MVP, EWSR1
6angiomyolipoma30.2KIT, DES, VIM
7adenocarcinoma30.0MDM2, MVP, CALB2, VIM, HMGA2, CDK4
8adenoma30.0HMGA2, CDK4, RB1, CALB2, PPARG
9pleomorphic adenoma30.0HMGA2
10synovial sarcoma29.7HMGA2, VIM, CALB2, MDM2, DES, KIT
11colorectal cancer29.7LRP1, CDK4, RB1, MVP, PPARG, MDM2
12clear cell sarcoma29.7ATF1, KIT, EWSR1, FUS
13dermatofibrosarcoma protuberans29.7VIM, KIT, DES
14angiosarcoma29.7CALB2, VIM
15desmoid tumor29.7DES, KIT
16teratoma29.7KIT
17desmoplastic small round cell tumor29.7EWSR1, DES
18amyotrophic lateral sclerosis29.7FUS, CALB2
19paraganglioma29.7KIT
20retroperitoneal liposarcoma11.0
21mediastinum liposarcoma10.5
22spindle cell liposarcoma10.5
23inflammatory liposarcoma10.5
24atypical lipomatous tumor10.5
25breast liposarcoma10.5
26mixed-type liposarcoma10.4
27esophagus liposarcoma10.4
28adult liposarcoma10.4
29larynx liposarcoma10.3
30gastric liposarcoma10.3
31sclerosing liposarcoma10.3
32kidney liposarcoma10.3
33cutaneous liposarcoma10.3
34spindle cell lipoma10.3
35pleomorphic lipoma10.2
36lipoblastoma10.2
37neurofibromatosis10.2
38pediatric liposarcoma10.2
39vulvar liposarcoma10.2
40lip disease10.2
41fibroblastic liposarcoma10.1
42cellular myxoid liposarcoma10.1
43intracranial liposarcoma10.1
44cardiac tamponade10.1
45leukemoid reaction10.1
46liposarcoma of bone10.1
47myxoid liposarcoma of the ovary10.1
48li-fraumeni syndrome10.1
49chest wall lipoma10.1
50soft tissue sarcoma10.1

Graphical network of the top 20 diseases related to Liposarcoma:



Diseases related to liposarcoma

Clinical Features for Liposarcoma

Drugs & Therapeutics for Liposarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Liposarcoma

Drug clinical trials:

Search ClinicalTrials for Liposarcoma

Search NIH Clinical Center for Liposarcoma

Search CenterWatch for Liposarcoma

Genetic Tests for Liposarcoma

Anatomical Context for Liposarcoma

Animal Models for Liposarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Liposarcoma:

37 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538611.2MDM2, DDIT3, VIM, CALB2, DES, CDK4
2MP:000538711.2MDM2, KIT, DDIT3, TSN, RB1, FUS
3MP:000538411.1VIM, EWSR1, PPARG, MDM2, RB1, DDIT3
4MP:000537811.1PPARG, VIM, CDK4, YBX1, LRP1, KIT
5MP:001076811.1LRP1, EWSR1, PPARG, MDM2, RB1, FUS
6MP:000363111.0KIT, HMGA2, LRP1, CDK4, PPARG, CALB2
7MP:000537911.0FUS, TSN, HMGA2, CDK4, DDIT3, RB1
8MP:000287311.0RB1, MVP, EWSR1, MDM2, CALB2, ATF1
9MP:000538910.9LRP1, EWSR1, FUS, TSN
10MP:000538510.9KIT, CDK4, LRP1, VIM, PPARG, MDM2
11MP:000536910.9LRP1, CDK4, RB1, MDM2
12MP:000537010.9KIT, YBX1, CDK4, PPARG, RB1, MDM2
13MP:000538010.9LRP1, ATF1, YBX1, VIM, PPARG
14MP:000539710.8FUS, RB1, KIT, TSN, YBX1, CDK4
15MP:001077110.8MDM2, RB1, CDK4, HMGA2, EWSR1
16MP:000537510.7TSN, LRP1, EWSR1, HMGA2
17MP:000200610.6PPARG, RB1, EWSR1, CDK4, KIT, MDM2
18MP:000539010.5EWSR1, RB1
19MP:000537610.3YBX1, CDK4, DES, LRP1, HMGA2

Publications for Liposarcoma

Sources:
51PubMed
See all sources

Articles related to Liposarcoma:

(show top 50)    (show all 1006)
idTitleAuthorsYear
1
Primary liposarcoma of the stomach. (23934465)
2013
2
Large retroperitoneal liposarcoma - a series of five cases. (24426516)
2013
3
Undiagnosed primary cardiac liposarcoma in an adult: a case report and review of the literature. (23629406)
2013
4
Medical image. Retroperitoneal liposarcoma. Giant retroperitoneal mass occupying nearly the whole abdomen. (24157996)
2013
5
Outpatient treatment for liposarcoma of the spermatic cord. (22699301)
2013
6
Laparoscopic resection of a retroperitoneal liposarcoma: a case report and review of the literature. (23971774)
2013
7
A huge retroperitoneal liposarcoma presenting as a hepatic space-occupying lesion: a case report. (22257481)
2012
8
Lymphocyte composition and distribution in inflammatory, well-differentiated retroperitoneal liposarcoma: clues to a potential adaptive immune response and therapeutic implications. (22446945)
2012
9
Clinicopathologic study of E-cadherin/beta-catenin complex, and topoisomerase-II in a series of 71 liposarcoma cases. (22300273)
2012
10
Primary Pulmonary Myxoid Liposarcoma with Translocation t(12;16)(q13;p11) in a Young Female Patient: A Brief Case Report. (23110035)
2012
11
Update on liposarcoma: a review for cytopathologists. (21932353)
2012
12
Pathology in practice. Widespread, metastatic liposarcoma and moderate, acute, diffuse centrilobular hepatic necrosis. (22309010)
2012
13
Myxoid liposarcoma of the ankle: a case report. (22018762)
2012
14
Dedifferentiated liposarcoma arising from the mesocolon ascendens: report of a case. (23123398)
2012
15
Giant liposarcoma of the esophagus with Li-Fraumeni-like syndrome. (21454085)
2011
16
Giant liposarcoma of the posterior mediastinum and retroperitoneum. (22688481)
2011
17
Giant atypical lipomatous tumor/well-differentiated liposarcoma of the neck. (21586964)
2011
18
Retroperitoneal liposarcoma with lamellar bone inside. (21397767)
2011
19
Aberrant AKT activation drives well-differentiated liposarcoma. (21930930)
2011
20
Thoraco-abdominal wall reconstruction after surgical debulking of a giant retroperitoneal liposarcoma: a case report. (21954745)
2011
21
Primary pleomorphic liposarcoma of breast: a rare case report. (21393893)
2011
22
Let-7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data. (21412931)
2011
23
Giant liposarcoma occupying most of the hemi-thorax and resected in the supine position: report of a rare case. (22251823)
2011
24
Pathology in practice. Liposarcoma. (21916756)
2011
25
Amyotrophic lateral sclerosis (ALS) and fused in sarcoma/translocated in liposarcoma (FUS/TLS)]. (22755220)
2011
26
Dedifferentiated liposarcoma of the retroperitoneum. (20369054)
2010
27
Core needle biopsy for diagnosis of giant thoracic liposarcoma. (21457645)
2010
28
Cytomorphology of dedifferentiated liposarcoma of the subcutis of the upper back with axillary lymph node metastasis: a case report. (20518422)
2010
29
Clinicopathologic prognostic factors of pure myxoid liposarcoma of the extremities and trunk wall. (20499293)
2010
30
Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules. (19652065)
2009
31
Characterization of the 12q amplicons by high-resolution, oligonucleotide array CGH and expression analyses of a novel liposarcoma cell line. (18160213)
2008
32
Involvement of c-jun in human liposarcoma growth: supporting data from clinical immunohistochemistry and DNAzyme efficacy. (18497564)
2008
33
Skeletal metastases in myxoid liposarcoma: an unusual pattern of distant spread. (17252290)
2007
34
Case report of vulvar liposarcoma. (15009607)
2004
35
Synthesis and secretion of apoC-I and apoE during maturation of human SW872 liposarcoma cells. (15514255)
2004
36
A leukemoid reaction in a patient with a dedifferentiated liposarcoma. (11391379)
2001
37
Distinction between lipoma and liposarcoma by MDM2 alterations: a case report of simultaneously occurring tumors and review of the literature. (11518050)
2001
38
Epithelioid variant of pleomorphic liposarcoma: a study of 12 cases of a distinctive variant of high-grade liposarcoma. (10430277)
1999
39
TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors. (9440806)
1998
40
Molecular abnormalities of the p53 pathway in dedifferentiated liposarcoma. (9071997)
1997
41
US case of the day. Myxoid liposarcoma of the spermatic cord. (9308118)
1997
42
Chromosome 12 breakpoints are cytogenetically different in benign and malignant lipogenic tumors: localization of breakpoints in lipoma to 12q15 and in myxoid liposarcoma to 12q13.3. (8453640)
1993
43
Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). (1283316)
1992
44
General case of the day. Myxoid liposarcoma. (2028068)
1991
45
Diagnosis and treatment of primary and recurrent retroperitoneal liposarcoma. (2023420)
1991
46
Uptake of technetium-99m DTPA in retroperitoneal liposarcoma. (2247624)
1990
47
Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2. (2372777)
1990
48
Translocation t(12;16)(q13;p11) in myxoid liposarcoma of a child and implication of the human int-1 gene in tumorigenesis. (2515180)
1989
49
Primary myxoid liposarcoma of the orbit. (3228546)
1988
50
Retroperitoneal liposarcoma in adult: a case report and review of literature. (13220855)
1954

Genetic Variations for Liposarcoma

Expression for genes affiliated with Liposarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Liposarcoma

Search GEO for disease gene expression data for Liposarcoma.

Pathways for genes affiliated with Liposarcoma

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore
See all sources

Compounds for genes affiliated with Liposarcoma

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Liposarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1vegf4511.3MVP, PPARG, MDM2, RB1, LRP1, YBX1
2retinoic acid45 2412.3POLR2L, HMGA2, KIT, RB1, DES, CDK4
3oligonucleotide4511.3ATF1, KIT, LRP1, YBX1, CDK4, POLR2L
4paraffin4511.2HMGA2, KIT, DES, RB1, MDM2, EWSR1
5doxorubicin45 50 1113.2POLR2L, DES, MDM2, CDK4, YBX1, MVP
6testosterone45 60 11 2414.2KIT, POLR2L, DES, VIM, DDIT3, RB1
7tyrosine4511.2YBX1, EWSR1, MDM2, LRP1, RB1, DDIT3
8leucine4511.2TSN, DDIT3, KIT, LRP1, CDK4, FUS
9progesterone45 60 29 11 2415.2KIT, CALB2, CDK4, MVP, MDM2, ATF1
10actinomycin d4511.2HMGA2, DDIT3, VIM, MDM2, DES, POLR2L
11cisplatin45 50 60 1114.1DDIT3, HMGA2, RB1, MDM2, MVP, CDK4
12paclitaxel45 50 1113.1MDM2, YBX1, MVP, CALB2, CDK4, RB1
13steroid4511.1YBX1, RB1, DES, ATF1, CDK4, MDM2
14nitric oxide45 11 2413.1RB1, CALB2, DES, KIT, CDK4, LRP1
15thymidylate4511.1CDK4, RB1, MDM2, MVP, VIM, POLR2L
16vincristine45 50 1113.1RB1, VIM, MVP, MDM2, KIT, YBX1
17lysine4511.1MDM2, YBX1, LRP1, POLR2L, DES, RB1
18threonine4511.1YBX1, LRP1, CDK4, POLR2L, DES, RB1
19camptothecin45 60 1113.1POLR2L, MVP, MDM2, RB1, CDK4, YBX1
205fluorouracil4511.1MVP, YBX1, KIT, CDK4, RB1, MDM2
21cyclic amp45 2412.1MDM2, EWSR1, VIM, CDK4, DES, ATF1
22roscovitine4511.0POLR2L, CDK4, VIM, RB1, MDM2
23flavopiridol45 1112.0POLR2L, MDM2, CDK4, KIT, RB1
24sb 20358045 6012.0RB1, PPARG, VIM, DDIT3, ATF1, CDK4
25etoposide45 50 60 1114.0RB1, DDIT3, MDM2, MVP, VIM, YBX1
26serine4511.0YBX1, POLR2L, EWSR1, ATF1, DES
27cysteine4511.0KIT, VIM, MDM2, RB1, DES, POLR2L
28p0024511.0DES, KIT, MDM2, RB1, MVP
29atp45 2912.0KIT, DDIT3, VIM, MVP, RB1, POLR2L
30rapamycin4511.0PPARG, MDM2, RB1, CDK4, KIT, VIM
31adriamycin4511.0MVP, VIM, DES, RB1, MDM2
32glycogen45 2412.0MDM2, VIM, CDK4, DES, LRP1, KIT
33bromodeoxyuridine4511.0DES, RB1, VIM, CDK4, DDIT3
34estrogen4511.0CALB2, MVP
35formaldehyde45 2411.9DES, RB1, POLR2L, KIT, VIM
36n-(4-hydroxyphenyl)retinamide4510.9CDK4, VIM, DDIT3, RB1
37genistein45 29 60 2 11 2415.9VIM, PPARG, MDM2, DDIT3, CDK4, RB1
38butyrate4510.9CALB2
39iron45 2411.9VIM, DES, MDM2, DDIT3, LEPREL1, CDK4
40hematoxylin4510.9KIT, CALB2, VIM, DES
41glucose4510.8LRP1, DDIT3, PPARG
42dexamethasone45 50 29 1113.8MDM2, RB1, CDK4, POLR2L
43toluidine4510.8DES, VIM, KIT
44carboplatin45 50 1112.7RB1, MDM2, DDIT3, CDK4
45mucicarmine4510.7DES, CALB2, VIM
46zinc45 2411.7RB1, POLR2L, CDK4, FUS, CALB2, EWSR1
47gefitinib45 50 1112.7VIM, CDK4, KIT, MDM2
48agar4510.6CDK4, RB1, VIM, YBX1, MDM2
49retinoid4510.5CDK4, POLR2L, VIM, PPARG, DDIT3
50arginine4510.4YBX1, CDK4, VIM, EWSR1, MDM2, DES

GO Terms for genes affiliated with Liposarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565410.7POLR2L, YBX1, CDK4, ATF1, DDIT3, RB1
2nucleusGO:00563410.7MVP, FUS, EWSR1, PPARG, MDM2, TSN
3extracellular vesicular exosomeGO:07006210.6YBX1, MVP, VIM

Biological processes related to Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.6MDM2, ATF1, POLR2L, KIT, PPARG
2negative regulation of transcription, DNA-dependentGO:04589210.6PPARG, MDM2, RB1, DDIT3, YBX1, HMGA2
3lipoprotein transportGO:04295310.2LRP1, PPARG

Molecular functions related to Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9DES, LRP1, YBX1, CDK4, EWSR1, ATF1
2DNA bindingGO:00367710.7PPARG, RB1, DDIT3, POLR2L, YBX1, HMGA2
3identical protein bindingGO:04280210.4FUS, RB1, MDM2, EWSR1, DES, VIM

Products for genes affiliated with Liposarcoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Liposarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet