MCID: LPS002
MIFTS: 60

Liposarcoma malady

Rare diseases, Cancer diseases categories
Download this MalaCard

Summaries for Liposarcoma

About this section


Fully expand this MalaCard
NIH Rare Diseases:42 Liposarcoma is a tumor that arises from fat tissue.  this tumor often occurs in the thigh, behind the knee, or in the abdomen, but it can be found in other parts of the body.  because a liposarcoma may grow into surrounding tissues or organs, it is considered a malignant tumor. last updated: 2/18/2011

MalaCards based summary: Liposarcoma is related to pleomorphic liposarcoma and myxoid liposarcoma. An important gene associated with Liposarcoma is LPSA (Oncogene liposarcoma (DNA segment, single copy, expressed, probes), and among its related pathways are DNA damage ATM ATR regulation of G1 S checkpoint and Oncogene Induced Senescence. The compounds roscovitine and benzo(a)pyrene have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and adipocyte, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Disease Ontology:8 A lipomatous cancer that arises in fat cells in deep soft tissue retroperitoneum.

Wikipedia:65 Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the... more...

Aliases & Classifications for Liposarcoma

About this section

Liposarcoma, Aliases & Descriptions:

Name: Liposarcoma 8 42 46 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:3382
MeSH34 D008080
NCIt39 C3194

Related Diseases for Liposarcoma

About this section

Diseases in the Liposarcoma family:

Adult Liposarcoma Inflammatory Liposarcoma

Diseases related to Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1pleomorphic liposarcoma31.7KIT, MDM2
2myxoid liposarcoma31.4ATF1, FUS, EWSR1, MDM2, CDK4
3lipoma31.0DES, FUS, HMGA2, MDM2, CDK4
4dedifferentiated liposarcoma30.9CDK4, MDM2, RB1, HMGA2, KIT, DES
5fibrous histiocytoma30.8DES, ATF1, FUS
6angiomyolipoma30.6KIT, DES
7hemangiopericytoma30.5MDM2, DES
8li-fraumeni syndrome30.4MDM2, RB1
9osteosarcoma30.3HMGA2, RB1, MDM2, CDK4
10desmoplastic small round cell tumor30.3EWSR1, DES
11leiomyoma30.2HMGA2, KIT, DES
12desmoid tumor30.2DES, KIT
13dermatofibrosarcoma protuberans30.2KIT, DES
14pleomorphic adenoma30.2MDM2, HMGA2, DES
15malignant peripheral nerve sheath tumor30.1KIT, MDM2
16leiomyosarcoma30.1DES, KIT, RB1, MDM2, CDK4
17rhabdomyosarcoma30.0DES, EWSR1, RB1, MDM2, CDK4
18adenoma29.9PPARG, HMGA2, RB1, CDK4
19b-cell lymphomas29.8HMGA2, RB1, MDM2, CDK4
20synovial sarcoma29.8MDM2, HMGA2, KIT, DES
21adenocarcinoma29.8CDK4, MDM2, RB1, HMGA2
22acute lymphoblastic leukemia29.7CDK4, RB1, HMGA2, KIT
23retinoblastoma29.7PPARG, RB1, MDM2, CDK4
24clear cell sarcoma29.6ATF1, FUS, EWSR1, KIT
25chondrosarcoma29.5DES, FUS, EWSR1, HMGA2, MDM2, CDK4
26sarcoma29.5EWSR1, FUS, ATF1, DES, KIT, HMGA2
27prostate cancer29.4LRP1, RB1, CDK4
28leukemia29.2ATF1, FUS, EWSR1, KIT, HMGA2, RB1
29colorectal cancer29.2PPARG, LRP1, RB1, MDM2, CDK4
30melanoma28.6DES, ATF1, LRP1, EWSR1, KIT, RB1
31breast cancer28.3PPARG, ATF1, LRP1, KIT, HMGA2, RB1
32retroperitoneal liposarcoma11.0
33mediastinitis10.6
34chondroma10.5HMGA2
35atypical lipomatous tumor10.5
36spindle cell liposarcoma10.5
37adenosarcoma10.5DES
38giant cell glioblastoma10.5MDM2
39gliosarcoma10.5CDK4
40myelofibrosis10.5HMGA2
41carney triad10.4KIT
42histiocytoma10.4
43inflammatory liposarcoma10.3
44liposarcoma of bone10.3
45anaplastic oligodendroglioma10.3CDK4, MDM2
46gastric liposarcoma10.3
47retinoblastoma fa - friedreich ataxia10.3RB1, MDM2
48breast liposarcoma10.3
49liposarcoma of the ovary10.3
50kidney liposarcoma10.3

Graphical network of the top 20 diseases related to Liposarcoma:



Diseases related to liposarcoma

Symptoms for Liposarcoma

About this section

Drugs & Therapeutics for Liposarcoma

About this section

Drug clinical trials:

Search ClinicalTrials for Liposarcoma

Search NIH Clinical Center for Liposarcoma

Genetic Tests for Liposarcoma

About this section

Anatomical Context for Liposarcoma

About this section

MalaCards organs/tissues related to Liposarcoma:

32
Bone, Breast, Adipocyte, Liver, Colon, Heart, Thyroid, Lung, Kidney, Prostate, Tongue, Bone marrow, Smooth muscle, Pancreas, Ovary, Uterus, Testes, Myeloid, B cells, Lymph node, Small intestine, Salivary gland, Adrenal gland, Testis, Appendix

Animal Models for Liposarcoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Liposarcoma:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8MDM2, RB1, HMGA2, KIT
2MP:00053778.6RB1, HMGA2, KIT, PPARG
3MP:00053678.5PPARG, EWSR1, KIT, MDM2, CDK4
4MP:00030128.4PPARG, FUS, KIT, RB1, MDM2
5MP:00020068.2PPARG, EWSR1, KIT, RB1, MDM2, CDK4
6MP:00053758.1PPARG, LRP1, EWSR1, HMGA2, RB1
7MP:00053798.0PPARG, FUS, EWSR1, KIT, HMGA2, RB1
8MP:00107717.9PPARG, EWSR1, KIT, HMGA2, RB1, MDM2
9MP:00053707.7PPARG, LRP1, KIT, RB1, MDM2, CDK4
10MP:00053907.5PPARG, LRP1, EWSR1, KIT, RB1, MDM2
11MP:00053857.3PPARG, DES, LRP1, KIT, RB1, MDM2
12MP:00053847.2PPARG, ATF1, FUS, EWSR1, KIT, RB1
13MP:00053807.1PPARG, ATF1, LRP1, KIT, RB1, MDM2
14MP:00053977.1PPARG, LRP1, FUS, EWSR1, KIT, RB1
15MP:00053697.1PPARG, DES, LRP1, EWSR1, KIT, RB1
16MP:00028737.0PPARG, ATF1, LRP1, EWSR1, KIT, RB1
17MP:00053866.9PPARG, DES, LRP1, FUS, KIT, HMGA2
18MP:00053896.9CDK4, PPARG, LRP1, FUS, EWSR1, KIT
19MP:00053766.8PPARG, DES, LRP1, KIT, HMGA2, RB1
20MP:00053786.8PPARG, LRP1, FUS, EWSR1, KIT, HMGA2
21MP:00036316.6PPARG, ATF1, LRP1, FUS, KIT, HMGA2
22MP:00053876.5PPARG, ATF1, LRP1, FUS, EWSR1, KIT
23MP:00107686.1PPARG, DES, ATF1, LRP1, FUS, EWSR1

Publications for Liposarcoma

About this section

Articles related to Liposarcoma:

(show top 50)    (show all 1045)
idTitleAuthorsYear
1
Primary dedifferentiated liposarcoma of the lung with rhabdomyoblastic and chrondroblastic differentiation. (24612243)
2014
2
Nuclear Expression of STAT6 in Dedifferentiated Liposarcomas With a Solitary Fibrous Tumor-like Morphology: A Diagnostic Pitfall. (25075469)
2014
3
Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma. (24788530)
2014
4
Estrogen receptor alpha and androgen receptor are commonly expressed in well-differentiated liposarcoma. (25349530)
2014
5
Cyclin-dependent kinase inhibitor 2A (p16) distinguishes well-differentiated liposarcoma from lipoma. (23600700)
2013
6
Palmar well differentiated spindle cell liposarcoma: presentation of a rare tumor at a rare site. (23413865)
2013
7
A mediastinal liposarcoma resected using a double approach with a thoracoscope. (25360414)
2013
8
Spermatic cord liposarcoma: organ-sparing surgery. (23814206)
2013
9
Huge mesenteric liposarcoma. (23901685)
2013
10
Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma. (23393200)
2013
11
Dedifferentiated liposarcoma of the retroperitoneum with osteosarcomatous component. (23426961)
2013
12
Metastatic pattern, local relapse, and survival of patients with myxoid liposarcoma: a retrospective study of 45 patients. (23864817)
2013
13
Lipoma or liposarcoma? A cautionary case report. (21865105)
2012
14
A huge retroperitoneal liposarcoma presenting as a hepatic space-occupying lesion: a case report. (22257481)
2012
15
Malignant nature of cardiac liposarcoma revealed by fluorine-18 fluorodeoxyglucose positron emission tomographic imaging. (22687843)
2012
16
Dedifferentiated subserosal liposarcoma of the jejunum: sonographic and computed tomographic findings with pathologic correlation. (22726982)
2012
17
The well-differentiated liposarcoma of the hypopharynx. (21602115)
2011
18
Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis. (21335544)
2011
19
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
20
Successful thoracoscopic resection of a large mediastinal liposarcoma. (21958801)
2011
21
Giant liposarcoma of the esophagus with Li-Fraumeni-like syndrome. (21454085)
2011
22
Composite reconstruction with cryopreserved fascia lata, single mandibular titanium plate, and polyglactin mesh after redo surgery and radiation therapy for recurrent chest wall liposarcoma. (20674942)
2011
23
Well-differentiated liposarcoma of the oesophagus: clinicopathological, immunohistochemical and array CGH analysis. (21038090)
2011
24
Myxoid liposarcoma with EWS-CHOP type 1 fusion gene. (21115923)
2010
25
Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature. (20604797)
2010
26
Liposarcoma of the spermatic cord: a diagnostic dilemma. (21234112)
2010
27
Liposarcoma: exploration of clinical prognostic factors for risk based stratification of therapy. (19558664)
2009
28
Effects of nutritional antioxidants on AAPH- or AGEs-induced oxidative stress in human SW872 liposarcoma cells. (19152116)
2009
29
Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance. (19386100)
2009
30
Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue. (18269578)
2008
31
Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. (16849546)
2006
32
MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. (16160477)
2005
33
Inguinal dedifferentiated liposarcoma with meningothelial-like whorls and metaplastic bone formation. (15842647)
2005
34
Radiology: radiology quiz case 2. Atypical lipomatous tumor, a variant of well-differentiated liposarcoma. (12525210)
2003
35
The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma. (10755400)
2000
36
Biochemical uncovering of mdm2/p53 complexes in liposarcomas parallels their immunohistochemical detection. (10565683)
1999
37
Distinct mdm2/p53 expression patterns in liposarcoma subgroups: implications for different pathogenetic mechanisms. (9071998)
1997
38
Complexity of 12q13-22 amplicon in liposarcoma: microsatellite repeat analysis. (8993982)
1997
39
Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction. (9311018)
1997
40
Gastric liposarcoma: CT appearance. (8508081)
1993
41
Paradoxical cerebral embolism originating from thrombus in tumour veins as presenting manifestation of retroperitoneal liposarcoma. (8461249)
1993
42
Divergent myosarcomatous differentiation in retroperitoneal liposarcoma. (8333554)
1993
43
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. (8510758)
1993
44
General case of the day. Myxoid liposarcoma. (2028068)
1991
45
Chromosomal evolution and tumor progression in a myxoid liposarcoma. (2193480)
1990
46
A complex translocation involving chromosomes 12 and 16 in a metastatic myxoid liposarcoma. (3395986)
1988
47
Case profile: computed tomography in retroperitoneal liposarcoma. (6868241)
1983
48
Crystalline inculsion in myxoid liposarcoma. (7282368)
1981
49
Ultrasonography and computed tomography of retroperitoneal liposarcoma. (7273837)
1981
50
Secondary liposarcoma of the ovary. (923891)
1977

Variations for Liposarcoma

About this section

Expression for genes affiliated with Liposarcoma

About this section
Expression patterns in normal tissues for genes affiliated with Liposarcoma

Search GEO for disease gene expression data for Liposarcoma.

Pathways for genes affiliated with Liposarcoma

About this section

Pathways related to Liposarcoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CDK4, MDM2
29.8CDK4, MDM2
39.6MDM2, RB1
49.6CDK4, RB1
59.5FUS, EWSR1, HMGA2
69.3CDK4, MDM2, RB1
79.3CDK4, MDM2, RB1
89.3CDK4, MDM2, RB1
9
Show member pathways
9.3CDK4, MDM2, RB1
10
Show member pathways
9.3CDK4, MDM2, RB1
11
Show member pathways
9.3CDK4, MDM2, RB1
12
Show member pathways
Signaling Pathways in Glioblastoma37
9.3RB1, MDM2, CDK4
13
Show member pathways
9.3RB1, MDM2, CDK4
14
Show member pathways
Cell cycle37
9.3RB1, MDM2, CDK4
15
Show member pathways
DNA damage response37
9.3RB1, MDM2, CDK4
16
Show member pathways
9.3RB1, MDM2, CDK4
179.3RB1, MDM2, CDK4
189.2MDM2, RB1, PPARG
199.0ATF1, RB1, CDK4
20
Show member pathways
9.0HMGA2, RB1, MDM2, CDK4
21
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.0ATF1, RB1, CDK4
22
Show member pathways
8.8CDK4, MDM2, RB1, KIT
23
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
8.7ATF1, RB1, MDM2, CDK4
248.7CDK4, MDM2, RB1, ATF1
25
Show member pathways
8.7PPARG, KIT, RB1, MDM2
268.3PPARG, KIT, RB1, MDM2, CDK4
278.1MDM2, HMGA2, EWSR1, FUS, ATF1, PPARG
28
Show member pathways
7.8DES, ATF1, KIT, RB1, MDM2, CDK4

Compounds for genes affiliated with Liposarcoma

About this section

Compounds related to Liposarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1roscovitine449.6RB1, MDM2, CDK4
2benzo(a)pyrene449.6CDK4, MDM2, RB1
3trastuzumab44 50 1111.6CDK4, MDM2, KIT
4gefitinib44 50 1111.6CDK4, MDM2, KIT
5carboplatin44 50 1111.5CDK4, MDM2, RB1
6geldanamycin44 50 61 1112.5KIT, MDM2, CDK4
7lead449.4KIT, MDM2, CDK4
8adpribose449.3DES, RB1, MDM2, CDK4
9thymidylate449.3CDK4, MDM2, RB1
10resveratrol44 61 24 1112.2CDK4, MDM2, RB1, PPARG
11p003449.2MDM2, RB1, KIT
12flavopiridol44 1110.2KIT, RB1, MDM2, CDK4
13p002449.1MDM2, RB1, KIT, DES
145fluorouracil449.1CDK4, MDM2, RB1, KIT
15estradiol44 24 1111.1DES, RB1, MDM2, CDK4
16ly294002449.1PPARG, RB1, MDM2, CDK4
17paclitaxel44 50 1111.1CDK4, MDM2, RB1, KIT
18vincristine44 50 1111.0MDM2, RB1, KIT
19genistein44 28 61 2 24 1114.0CDK4, MDM2, RB1, PPARG
2012-o-tetradecanoylphorbol 13-acetate449.0DES, ATF1, RB1, CDK4
21lovastatin44 50 61 28 1112.9LRP1, RB1, CDK4
22zinc44 249.9FUS, EWSR1, RB1, MDM2, CDK4
23sb 20358044 619.9PPARG, ATF1, RB1, CDK4
24iron44 249.9DES, LEPREL1, MDM2, CDK4
25actinomycin d448.8DES, KIT, HMGA2, RB1, MDM2
26thymidine44 249.8DES, KIT, RB1, MDM2, CDK4
27rapamycin448.7PPARG, KIT, RB1, MDM2, CDK4
28pd 98,059448.6ATF1, KIT, RB1, MDM2, CDK4
29doxorubicin44 50 1110.5DES, KIT, HMGA2, RB1, MDM2, CDK4
30glycogen44 249.5DES, LRP1, KIT, MDM2, CDK4
31lysine448.4MDM2, RB1, LRP1, DES
32testosterone44 61 24 1111.4PPARG, DES, KIT, RB1, MDM2, CDK4
33dexamethasone44 50 28 1111.3PPARG, LRP1, RB1, MDM2, CDK4
34cyclic amp44 249.3DES, ATF1, EWSR1, RB1, MDM2, CDK4
35estrogen448.3PPARG, DES, KIT, RB1, MDM2, CDK4
36phosphatidylinositol448.2LRP1, KIT, RB1, MDM2, CDK4
37progesterone44 28 61 24 1112.2DES, ATF1, KIT, RB1, MDM2, CDK4
38steroid448.2DES, ATF1, KIT, RB1, MDM2, CDK4
39paraffin448.1CDK4, DES, EWSR1, KIT, HMGA2, RB1
40nitric oxide44 24 1110.0DES, LRP1, KIT, RB1, MDM2, CDK4
41threonine448.0DES, LRP1, KIT, RB1, MDM2, CDK4
42cysteine447.9DES, LRP1, KIT, RB1, MDM2, CDK4
43leucine447.8ATF1, LRP1, FUS, KIT, RB1, CDK4
44vegf447.6PPARG, DES, LRP1, KIT, RB1, MDM2
45tyrosine447.5DES, LRP1, EWSR1, KIT, RB1, MDM2
46oligonucleotide447.4ATF1, LRP1, EWSR1, KIT, RB1, MDM2
47glucose447.2PPARG, DES, ATF1, LRP1, KIT, RB1
48retinoic acid44 248.2PPARG, DES, LRP1, EWSR1, KIT, HMGA2
49serine447.0DES, ATF1, LRP1, EWSR1, KIT, RB1
50calcium44 50 24 119.9DES, ATF1, LRP1, EWSR1, KIT, RB1

GO Terms for genes affiliated with Liposarcoma

About this section

Cellular components related to Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056547.3CDK4, PPARG, ATF1, FUS, HMGA2, RB1
2nucleusGO:0056346.4ATF1, LRP1, FUS, EWSR1, HMGA2, RB1

Biological processes related to Liposarcoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:07115710.0CDK4, MDM2
2stem cell differentiationGO:0488639.8HMGA2, KIT
3somatic stem cell maintenanceGO:0350199.6HMGA2, KIT
4digestive tract developmentGO:0485659.5KIT, RB1
5positive regulation of gene expressionGO:0106289.5MDM2, HMGA2, KIT
6positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5HMGA2, KIT, PPARG
7lipoprotein transportGO:0429539.4PPARG, LRP1
8response to drugGO:0424939.4CDK4, MDM2, PPARG
9negative regulation of transcription, DNA-templatedGO:0458929.1MDM2, RB1, HMGA2, PPARG
10neurotrophin TRK receptor signaling pathwayGO:0480118.7ATF1, KIT, MDM2
11innate immune responseGO:0450878.6MDM2, KIT, ATF1, PPARG
12positive regulation of transcription from RNA polymerase II promoterGO:0459448.6PPARG, ATF1, HMGA2, RB1

Molecular functions related to Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.4MDM2, HMGA2, PPARG
2core promoter bindingGO:0010479.4HMGA2, RB1
3protein complex bindingGO:0324038.6CDK4, LRP1, ATF1
4identical protein bindingGO:0428028.6DES, FUS, EWSR1, RB1, MDM2
5protein bindingGO:0055155.6CDK4, PPARG, DES, ATF1, LRP1, FUS

Products for genes affiliated with Liposarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Liposarcoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet