MCID: LPS002
MIFTS: 61

Liposarcoma malady

Rare diseases, Cancer diseases categories
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Summaries for Liposarcoma

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8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Liposarcoma is a tumor that arises from fat tissue.  this tumor often occurs in the thigh, behind the knee, or in the abdomen, but it can be found in other parts of the body.  because a liposarcoma may grow into surrounding tissues or organs, it is considered a malignant tumor. last updated: 2/18/2011

MalaCards: Liposarcoma, also known as liposarcoma nos, is related to myxoid liposarcoma and pleomorphic liposarcoma. An important gene associated with Liposarcoma is LPSA (Oncogene liposarcoma (DNA segment, single copy, expressed, probes), and among its related pathways are DNA damage ATM ATR regulation of G1 S checkpoint and Oncogene Induced Senescence. The compounds roscovitine and benzo(a)pyrene have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and adipocyte, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Disease Ontology:8 A malignant lipomatous neoplasm that arises in fat cells in deep soft tissue retroperitoneum.

Wikipedia:65 Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the... more...

Aliases & Classifications for Liposarcoma

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8Disease Ontology, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

liposarcoma 8 43 47 10 45 62
liposarcoma nos 8


External Ids:

Disease Ontology8 DOID:3382
NCIt40 C3194
MeSH35 D008080

Related Diseases for Liposarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Liposarcoma family:

Inflammatory Liposarcoma Adult Liposarcoma

Diseases related to Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1myxoid liposarcoma31.5ATF1, FUS, EWSR1, MDM2, CDK4
2pleomorphic liposarcoma31.3KIT, MDM2
3dedifferentiated liposarcoma31.3CDK4, MDM2, RB1, HMGA2, KIT, DES
4lipoma31.0DES, FUS, HMGA2, MDM2, CDK4
5fibrous histiocytoma30.6DES, ATF1, FUS
6sarcoma30.5EWSR1, FUS, ATF1, DES, KIT, HMGA2
7leiomyosarcoma30.4DES, KIT, RB1, MDM2, CDK4
8angiomyolipoma30.3KIT, DES
9osteosarcoma30.3HMGA2, RB1, MDM2, CDK4
10hemangiopericytoma30.1MDM2, DES
11li-fraumeni syndrome30.1MDM2, RB1
12rhabdomyosarcoma30.1DES, EWSR1, RB1, MDM2, CDK4
13leiomyoma30.0HMGA2, KIT, DES
14leukemia30.0ATF1, FUS, EWSR1, KIT, HMGA2, RB1
15adenoma30.0PPARG, HMGA2, RB1, CDK4
16adenocarcinoma29.9CDK4, MDM2, RB1, HMGA2
17desmoplastic small round cell tumor29.9EWSR1, DES
18desmoid tumor29.9DES, KIT
19dermatofibrosarcoma protuberans29.9KIT, DES
20pleomorphic adenoma29.9MDM2, HMGA2, DES
21malignant peripheral nerve sheath tumor29.8KIT, MDM2
22b-cell lymphomas29.8HMGA2, RB1, MDM2, CDK4
23synovial sarcoma29.8MDM2, HMGA2, KIT, DES
24melanoma29.8DES, ATF1, LRP1, EWSR1, KIT, RB1
25retinoblastoma29.7PPARG, RB1, MDM2, CDK4
26clear cell sarcoma29.7ATF1, FUS, EWSR1, KIT
27chondrosarcoma29.7DES, FUS, EWSR1, HMGA2, MDM2, CDK4
28prostate cancer29.7LRP1, RB1, CDK4
29colorectal cancer29.6PPARG, LRP1, RB1, MDM2, CDK4
30breast cancer29.4PPARG, ATF1, LRP1, KIT, HMGA2, RB1
31retroperitoneal liposarcoma10.9
32mediastinitis10.5
33atypical lipomatous tumor10.5
34spindle cell liposarcoma10.5
35mixed-type liposarcoma10.4
36histiocytoma10.4
37inflammatory liposarcoma10.3
38liposarcoma of bone10.3
39gastric liposarcoma10.2
40fibrosarcoma10.2
41thyroiditis10.2
42lipoblastoma10.2
43neurofibromatosis10.2
44larynx liposarcoma10.2
45mediastinum liposarcoma10.2
46breast liposarcoma10.2
47sclerosing liposarcoma10.2
48liposarcoma of the ovary10.2
49mesenchymoma10.2
50pancreatitis10.2

Graphical network of the top 20 diseases related to Liposarcoma:



Diseases related to liposarcoma

Symptoms for Liposarcoma

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Drugs & Therapeutics for Liposarcoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Liposarcoma

Search NIH Clinical Center for Liposarcoma

Genetic Tests for Liposarcoma

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Anatomical Context for Liposarcoma

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33MalaCards
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MalaCards organs/tissues related to Liposarcoma:

33
Bone, Breast, Adipocyte, Liver, Colon, Heart, Thyroid, Lung, Prostate, Kidney, Bone marrow, Uterus, Pancreas, Tongue, B cells, Myeloid, Ovary, Smooth muscle, Lymph node, Testes, Salivary gland, Adrenal gland, Testis, Appendix, Small intestine

Animal Models for Liposarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Liposarcoma:

37 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8MDM2, RB1, HMGA2, KIT
2MP:00053778.6RB1, HMGA2, KIT, PPARG
3MP:00053678.5PPARG, EWSR1, KIT, MDM2, CDK4
4MP:00030128.4PPARG, FUS, KIT, RB1, MDM2
5MP:00020068.2PPARG, EWSR1, KIT, RB1, MDM2, CDK4
6MP:00053758.1PPARG, LRP1, EWSR1, HMGA2, RB1
7MP:00053798.0PPARG, FUS, EWSR1, KIT, HMGA2, RB1
8MP:00107717.9PPARG, EWSR1, KIT, HMGA2, RB1, MDM2
9MP:00053707.7PPARG, LRP1, KIT, RB1, MDM2, CDK4
10MP:00053907.5PPARG, LRP1, EWSR1, KIT, RB1, MDM2
11MP:00053857.3PPARG, DES, LRP1, KIT, RB1, MDM2
12MP:00053847.2PPARG, ATF1, FUS, EWSR1, KIT, RB1
13MP:00053807.1PPARG, ATF1, LRP1, KIT, RB1, MDM2
14MP:00053977.1PPARG, LRP1, FUS, EWSR1, KIT, RB1
15MP:00053697.1PPARG, DES, LRP1, EWSR1, KIT, RB1
16MP:00028737.0PPARG, ATF1, LRP1, EWSR1, KIT, RB1
17MP:00053866.9PPARG, DES, LRP1, FUS, KIT, HMGA2
18MP:00053896.9CDK4, PPARG, LRP1, FUS, EWSR1, KIT
19MP:00053766.8PPARG, DES, LRP1, KIT, HMGA2, RB1
20MP:00053786.8PPARG, LRP1, FUS, EWSR1, KIT, HMGA2
21MP:00036316.6PPARG, ATF1, LRP1, FUS, KIT, HMGA2
22MP:00053876.5PPARG, ATF1, LRP1, FUS, EWSR1, KIT
23MP:00107686.1PPARG, DES, ATF1, LRP1, FUS, EWSR1

Publications for Liposarcoma

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52PubMed
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Articles related to Liposarcoma:

(show top 50)    (show all 983)
idTitleAuthorsYear
1
Cyclin-dependent kinase inhibitor 2A (p16) distinguishes well-differentiated liposarcoma from lipoma. (23600700)
2013
2
Palmar well differentiated spindle cell liposarcoma: presentation of a rare tumor at a rare site. (23413865)
2013
3
Spermatic cord liposarcoma: organ-sparing surgery. (23814206)
2013
4
Huge mesenteric liposarcoma. (23901685)
2013
5
Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma. (23393200)
2013
6
Dedifferentiated liposarcoma of the retroperitoneum with osteosarcomatous component. (23426961)
2013
7
Metastatic pattern, local relapse, and survival of patients with myxoid liposarcoma: a retrospective study of 45 patients. (23864817)
2013
8
High level of CDK4 amplification is a poor prognostic factor in well-differentiated and dedifferentiated liposarcoma. (23852861)
2013
9
Primary liposarcoma of the stomach. (23934465)
2013
10
Lipoma or liposarcoma? A cautionary case report. (21865105)
2012
11
A huge retroperitoneal liposarcoma presenting as a hepatic space-occupying lesion: a case report. (22257481)
2012
12
Malignant nature of cardiac liposarcoma revealed by fluorine-18 fluorodeoxyglucose positron emission tomographic imaging. (22687843)
2012
13
Dedifferentiated subserosal liposarcoma of the jejunum: sonographic and computed tomographic findings with pathologic correlation. (22726982)
2012
14
The well-differentiated liposarcoma of the hypopharynx. (21602115)
2011
15
Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis. (21335544)
2011
16
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
17
Giant liposarcoma of the esophagus with Li-Fraumeni-like syndrome. (21454085)
2011
18
Composite reconstruction with cryopreserved fascia lata, single mandibular titanium plate, and polyglactin mesh after redo surgery and radiation therapy for recurrent chest wall liposarcoma. (20674942)
2011
19
Well-differentiated liposarcoma of the oesophagus: clinicopathological, immunohistochemical and array CGH analysis. (21038090)
2011
20
Myxoid liposarcoma with EWS-CHOP type 1 fusion gene. (21115923)
2010
21
Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature. (20604797)
2010
22
Liposarcoma of the spermatic cord: a diagnostic dilemma. (21234112)
2010
23
Limb salvage operation using intraoperative extracorporeal autogenous irradiated bone and tendon graft for myxoid liposarcoma on dorsum of foot. (20598521)
2010
24
Liposarcoma: exploration of clinical prognostic factors for risk based stratification of therapy. (19558664)
2009
25
Effects of nutritional antioxidants on AAPH- or AGEs-induced oxidative stress in human SW872 liposarcoma cells. (19152116)
2009
26
Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance. (19386100)
2009
27
Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue. (18269578)
2008
28
Multicentric myxoid liposarcoma: report of two cases. (18070341)
2007
29
Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. (16849546)
2006
30
MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. (16160477)
2005
31
Inguinal dedifferentiated liposarcoma with meningothelial-like whorls and metaplastic bone formation. (15842647)
2005
32
Primary dedifferentiated liposarcoma of the lung. (15910606)
2005
33
Radiology: radiology quiz case 2. Atypical lipomatous tumor, a variant of well-differentiated liposarcoma. (12525210)
2003
34
The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma. (10755400)
2000
35
Expression of growth hormone receptor in human liposarcomas and lipomas. (10854539)
2000
36
Biochemical uncovering of mdm2/p53 complexes in liposarcomas parallels their immunohistochemical detection. (10565683)
1999
37
Distinct mdm2/p53 expression patterns in liposarcoma subgroups: implications for different pathogenetic mechanisms. (9071998)
1997
38
Complexity of 12q13-22 amplicon in liposarcoma: microsatellite repeat analysis. (8993982)
1997
39
Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction. (9311018)
1997
40
Gastric liposarcoma: CT appearance. (8508081)
1993
41
Paradoxical cerebral embolism originating from thrombus in tumour veins as presenting manifestation of retroperitoneal liposarcoma. (8461249)
1993
42
Divergent myosarcomatous differentiation in retroperitoneal liposarcoma. (8333554)
1993
43
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. (8510758)
1993
44
General case of the day. Myxoid liposarcoma. (2028068)
1991
45
Chromosomal evolution and tumor progression in a myxoid liposarcoma. (2193480)
1990
46
A complex translocation involving chromosomes 12 and 16 in a metastatic myxoid liposarcoma. (3395986)
1988
47
Case profile: computed tomography in retroperitoneal liposarcoma. (6868241)
1983
48
Crystalline inculsion in myxoid liposarcoma. (7282368)
1981
49
Ultrasonography and computed tomography of retroperitoneal liposarcoma. (7273837)
1981
50
Secondary liposarcoma of the ovary. (923891)
1977

Variations for Liposarcoma

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Expression for genes affiliated with Liposarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Liposarcoma

Search GEO for disease gene expression data for Liposarcoma.

Pathways for genes affiliated with Liposarcoma

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Sources:
50PathCards, 60Thomson Reuters, 55Reactome, 53QIAGEN, 38NCBI BioSystems Database, 5Cell Signaling Technology, 30KEGG, 57SinoBiological, 54R&D Systems
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Pathways related to Liposarcoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CDK4, MDM2
29.8CDK4, MDM2
39.6MDM2, RB1
49.6CDK4, RB1
59.5FUS, EWSR1, HMGA2
69.3CDK4, MDM2, RB1
79.3CDK4, MDM2, RB1
89.3CDK4, MDM2, RB1
9
Show member pathways
9.3CDK4, MDM2, RB1
10
Show member pathways
9.3CDK4, MDM2, RB1
11
Show member pathways
9.3CDK4, MDM2, RB1
12
Show member pathways
Signaling Pathways in Glioblastoma38
9.3RB1, MDM2, CDK4
13
Show member pathways
9.3RB1, MDM2, CDK4
14
Show member pathways
Cell cycle38
9.3RB1, MDM2, CDK4
15
Show member pathways
DNA damage response38
9.3RB1, MDM2, CDK4
16
Show member pathways
9.3RB1, MDM2, CDK4
179.3RB1, MDM2, CDK4
189.2MDM2, RB1, PPARG
199.0ATF1, RB1, CDK4
20
Show member pathways
9.0HMGA2, RB1, MDM2, CDK4
21
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.0ATF1, RB1, CDK4
22
Show member pathways
8.8CDK4, MDM2, RB1, KIT
23
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
8.7ATF1, RB1, MDM2, CDK4
248.7CDK4, MDM2, RB1, ATF1
25
Show member pathways
8.7PPARG, KIT, RB1, MDM2
268.3PPARG, KIT, RB1, MDM2, CDK4
278.1MDM2, HMGA2, EWSR1, FUS, ATF1, PPARG
28
Show member pathways
7.8DES, ATF1, KIT, RB1, MDM2, CDK4

Compounds for genes affiliated with Liposarcoma

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 3BitterDB
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Compounds related to Liposarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1roscovitine459.6RB1, MDM2, CDK4
2benzo(a)pyrene459.6CDK4, MDM2, RB1
3trastuzumab45 51 1111.6CDK4, MDM2, KIT
4gefitinib45 51 1111.6CDK4, MDM2, KIT
5carboplatin45 51 1111.5CDK4, MDM2, RB1
6geldanamycin45 51 61 1112.5KIT, MDM2, CDK4
7lead459.4KIT, MDM2, CDK4
8adpribose459.3DES, RB1, MDM2, CDK4
9thymidylate459.3CDK4, MDM2, RB1
10resveratrol45 61 24 1112.2CDK4, MDM2, RB1, PPARG
11p003459.2MDM2, RB1, KIT
12flavopiridol45 1110.2KIT, RB1, MDM2, CDK4
13p002459.1MDM2, RB1, KIT, DES
145fluorouracil459.1CDK4, MDM2, RB1, KIT
15estradiol45 24 1111.1DES, RB1, MDM2, CDK4
16ly294002459.1PPARG, RB1, MDM2, CDK4
17paclitaxel45 51 1111.1CDK4, MDM2, RB1, KIT
18vincristine45 51 1111.0MDM2, RB1, KIT
19genistein45 29 61 3 24 1114.0CDK4, MDM2, RB1, PPARG
2012-o-tetradecanoylphorbol 13-acetate459.0DES, ATF1, RB1, CDK4
21lovastatin45 51 61 29 1112.9LRP1, RB1, CDK4
22zinc45 249.9FUS, EWSR1, RB1, MDM2, CDK4
23sb 20358045 619.9PPARG, ATF1, RB1, CDK4
24iron45 249.9DES, LEPREL1, MDM2, CDK4
25actinomycin d458.8DES, KIT, HMGA2, RB1, MDM2
26thymidine45 249.8DES, KIT, RB1, MDM2, CDK4
27rapamycin458.7PPARG, KIT, RB1, MDM2, CDK4
28pd 98,059458.6ATF1, KIT, RB1, MDM2, CDK4
29doxorubicin45 51 1110.5DES, KIT, HMGA2, RB1, MDM2, CDK4
30glycogen45 249.5DES, LRP1, KIT, MDM2, CDK4
31lysine458.4MDM2, RB1, LRP1, DES
32testosterone45 61 24 1111.4PPARG, DES, KIT, RB1, MDM2, CDK4
33dexamethasone45 51 29 1111.3PPARG, LRP1, RB1, MDM2, CDK4
34cyclic amp45 249.3DES, ATF1, EWSR1, RB1, MDM2, CDK4
35estrogen458.3PPARG, DES, KIT, RB1, MDM2, CDK4
36phosphatidylinositol458.2LRP1, KIT, RB1, MDM2, CDK4
37progesterone45 29 61 24 1112.2DES, ATF1, KIT, RB1, MDM2, CDK4
38steroid458.2DES, ATF1, KIT, RB1, MDM2, CDK4
39paraffin458.1CDK4, DES, EWSR1, KIT, HMGA2, RB1
40nitric oxide45 24 1110.0DES, LRP1, KIT, RB1, MDM2, CDK4
41threonine458.0DES, LRP1, KIT, RB1, MDM2, CDK4
42cysteine457.9DES, LRP1, KIT, RB1, MDM2, CDK4
43leucine457.8ATF1, LRP1, FUS, KIT, RB1, CDK4
44vegf457.6PPARG, DES, LRP1, KIT, RB1, MDM2
45tyrosine457.5DES, LRP1, EWSR1, KIT, RB1, MDM2
46oligonucleotide457.4ATF1, LRP1, EWSR1, KIT, RB1, MDM2
47glucose457.2PPARG, DES, ATF1, LRP1, KIT, RB1
48retinoic acid45 248.2PPARG, DES, LRP1, EWSR1, KIT, HMGA2
49serine457.0DES, ATF1, LRP1, EWSR1, KIT, RB1
50calcium45 51 24 119.9DES, ATF1, LRP1, EWSR1, KIT, RB1

GO Terms for genes affiliated with Liposarcoma

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16Gene Ontology
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Cellular components related to Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056547.3CDK4, PPARG, ATF1, FUS, HMGA2, RB1
2nucleusGO:0056346.4ATF1, LRP1, FUS, EWSR1, HMGA2, RB1

Biological processes related to Liposarcoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:07115710.0CDK4, MDM2
2stem cell differentiationGO:0488639.8HMGA2, KIT
3somatic stem cell maintenanceGO:0350199.6HMGA2, KIT
4digestive tract developmentGO:0485659.5KIT, RB1
5positive regulation of gene expressionGO:0106289.5MDM2, HMGA2, KIT
6positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5HMGA2, KIT, PPARG
7lipoprotein transportGO:0429539.4PPARG, LRP1
8response to drugGO:0424939.4CDK4, MDM2, PPARG
9negative regulation of transcription, DNA-templatedGO:0458929.1MDM2, RB1, HMGA2, PPARG
10neurotrophin TRK receptor signaling pathwayGO:0480118.7ATF1, KIT, MDM2
11innate immune responseGO:0450878.6MDM2, KIT, ATF1, PPARG
12positive regulation of transcription from RNA polymerase II promoterGO:0459448.6PPARG, ATF1, HMGA2, RB1

Molecular functions related to Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.4MDM2, HMGA2, PPARG
2core promoter bindingGO:0010479.4HMGA2, RB1
3protein complex bindingGO:0324038.6CDK4, LRP1, ATF1
4identical protein bindingGO:0428028.6DES, FUS, EWSR1, RB1, MDM2
5protein bindingGO:0055155.6CDK4, PPARG, DES, ATF1, LRP1, FUS

Products for genes affiliated with Liposarcoma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Liposarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet