MCID: LST001
MIFTS: 55

Listeriosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Listeriosis

MalaCards integrated aliases for Listeriosis:

Name: Listeriosis 12 72 49 55 51 3 41 14 69
Listeria Infection 12 72 49 55
Infection by Listeria Monocytogenes 12
Listeria Monocytogenes Infection 49
Listeria Infections 40

Characteristics:

Orphanet epidemiological data:

55
listeriosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Worldwide),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11573
ICD10 32 A32 A32.9
ICD9CM 34 027.0
MeSH 41 D008088
NCIt 46 C82994
Orphanet 55 ORPHA533
MESH via Orphanet 42 D008088
UMLS via Orphanet 70 C0023860
ICD10 via Orphanet 33 A32.0 A32.1 A32.7 more
UMLS 69 C0023860

Summaries for Listeriosis

NIH Rare Diseases : 49 A listeria infection or listeriosis is an infection caused by a bacteria known as Listeria monocytogenes. It mainly affects newborn infants, elderly patients, pregnant women and patients who have low immunity. Listeria can be spread by several methods. A common cause is ingestion (food-borne transmission) of unpasteurized milk or contaminated vegetables. It can also be transmitted from mother to fetus during pregnancy or directly to the newborn at the time of delivery. Listeriosis can cause a variety of symptoms, depending on the person and the part of the body affected. Pregnant women typically have only fever and other flu-like symptoms, such as fatigue and muscle aches. However, infections during pregnancy can lead to miscarriage, stillbirth, premature delivery, or life-threatening infection of the newborn, including generalized infection (sepsis) or inflammation of the membranes that cover the brain (meningitis). Sometimes listeriosis involves many organs and presents with masses filled with pus (microabscesses or granulomas). Older children with Listeria infections frequently develop meningitis.  Treatment include antibiotics such as ampicillin and aminoglycosides. Last updated: 7/12/2017

MalaCards based summary : Listeriosis, also known as listeria infection, is related to toxoplasmosis and meningitis, and has symptoms including nausea, vomiting and diarrhea. An important gene associated with Listeriosis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Immune response IFN alpha/beta signaling pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Amoxicillin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and liver, and related phenotypes are integument and liver/biliary system

MedlinePlus : 40 Listeriosis is a foodborne illness caused by Listeria monocytogenes, bacteria found in soil and water. It can be in a variety of raw foods as well as in processed foods and foods made from unpasteurized milk. Listeria is unlike many other germs because it can grow even in the cold temperature of the refrigerator. Symptoms include fever and chills, headache, upset stomach and vomiting. Treatment is with antibiotics. Anyone can get the illness. But it is most likely to affect pregnant women and unborn babies, older adults, and people with weak immune systems. To reduce your risk Use precooked and ready-to-eat foods as soon as you can Avoid raw milk and raw milk products Heat ready-to-eat foods and leftovers until they are steaming hot Wash fresh fruits and vegetables Avoid rare meat and refrigerated smoked seafood Centers for Disease Control and Prevention

CDC : 3 Get answers to commonly asked questions about Listeria

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection, has material basis in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has symptom nausea, has symptom vomiting, has symptom diarrhea, has symptom fever, has symptom malaise, has symptom back pain, and has symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

Wikipedia : 72 Listeriosis is a bacterial infection most commonly caused by Listeria monocytogenes, although... more...

Related Diseases for Listeriosis

Diseases related to Listeriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 toxoplasmosis 30.3 IL10 IL6 TNF
2 meningitis 29.8 IL10 IL6 MBL2 TNF
3 connective tissue disease 29.8 IL10 IL6 TNF
4 cytomegalovirus infection 29.8 IL10 IL6 TNF
5 gastroenteritis 29.7 CDH1 IL10 IL6 TNF
6 mycobacterium tuberculosis 1 29.7 IL10 MBL2 TNF
7 brucellosis 29.7 IL10 IL6 TNF
8 listeria meningitis 29.6 NDUFA9 TNF
9 chlamydia 29.5 IDO1 IL10 IL6 TNF
10 otitis media 29.5 IL10 IL6 MBL2 TNF
11 colitis 29.4 IL10 IL6 TNF
12 multiple sclerosis 29.2 IL10 IL6 PRF1 TNF
13 systemic onset juvenile idiopathic arthritis 10.5 PRF1 TNF
14 scorpion envenomation 10.5 IL6 TNF
15 punctate inner choroidopathy 10.5 IL10 TNF
16 vulvar vestibulitis syndrome 10.5 MBL2 TNF
17 tropical endomyocardial fibrosis 10.5 IL10 TNF
18 adult dermatomyositis 10.5 MBL2 TNF
19 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
20 critical limb ischemia 10.4 IL6 TNF
21 microscopic polyangiitis 10.4 IL10 TNF
22 streptococcal toxic-shock syndrome 10.4 IL6 TNF
23 multifocal choroiditis 10.4 IL10 TNF
24 null-cell leukemia 10.4 IL6 TNF
25 tungiasis 10.4 IL10 TNF
26 endomyocardial fibrosis 10.4 IL10 TNF
27 transient hypogammaglobulinemia 10.4 IL10 TNF
28 scabies 10.4 IL10 MBL2
29 retinitis pigmentosa 55 10.4 IL6 TNF
30 choroiditis 10.4 IL10 TNF
31 mannose-binding lectin deficiency 10.3 IL6 MBL2
32 glossitis 10.3 IL6 TNF
33 laryngitis 10.3 IL6 TNF
34 macrophage activation syndrome 10.3 PRF1 TNF
35 trichuriasis 10.3 IDO1 IL10 TNF
36 trachoma 10.3 IDO1 IL10 TNF
37 eye lymphoma 10.3 IL10 IL6
38 mucocutaneous leishmaniasis 10.3 IL10 TNF
39 acute transverse myelitis 10.3 IL10 IL6
40 idiopathic achalasia 10.3 IL10 TNF
41 anterior uveitis 10.3 IL6 TNF
42 cerebral palsy 10.3 IL6 MBL2 TNF
43 funisitis 10.2 IL10 IL6
44 acute vascular insufficiency of intestine 10.2 IL6 TNF
45 epstein-barr virus-associated gastric carcinoma 10.2 CDH1 IL10 TNF
46 clonorchiasis 10.2 IL10 TNF
47 pulmonary tuberculosis 10.2 IL10 MBL2 TNF
48 immune suppression 10.2 IDO1 IL10 IL6
49 transverse myelitis 10.2 IL10 IL6 TNF
50 intermediate uveitis 10.2 IL10 IL6 TNF

Comorbidity relations with Listeriosis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Listeriosis:



Diseases related to Listeriosis

Symptoms & Phenotypes for Listeriosis

Symptoms:

12
  • nausea
  • vomiting
  • diarrhea
  • fever
  • malaise
  • back pain
  • headache

UMLS symptoms related to Listeriosis:


pruritus, fever

MGI Mouse Phenotypes related to Listeriosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.7 CDH1 IL10 IL6 LIPI LXN PRF1
2 liver/biliary system MP:0005370 9.43 ACTA1 IL10 IL6 LIPI PRF1 TNF
3 reproductive system MP:0005389 9.17 ACTA1 CDH1 IDO1 IL10 IL6 PRF1

Drugs & Therapeutics for Listeriosis

Drugs for Listeriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
2 Anti-Bacterial Agents
3 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Incidence, Risk Factors and Impact on Renal Function of the Appearance of Crystalluria Under High-dose Intravenous Amoxicillin Completed NCT02853292
2 Genetic Susceptibility to Listeriosis Recruiting NCT03357536
3 National Study on Listeriosis and Listeria Recruiting NCT01520597
4 Neurological Consequences of Perinatal Listeriosis Infection Recruiting NCT02580812
5 Genetic Susceptibility and Biomarkers in Listeriosis Enrolling by invitation NCT02924220

Search NIH Clinical Center for Listeriosis

Cochrane evidence based reviews: listeriosis

Genetic Tests for Listeriosis

Anatomical Context for Listeriosis

MalaCards organs/tissues related to Listeriosis:

38
Brain, T Cells, Liver, Bone Marrow, Bone, Neutrophil, Placenta

Publications for Listeriosis

Articles related to Listeriosis:

(show top 50) (show all 635)
# Title Authors Year
1
Genetic characterization of Listeria monocytogenes from ruminant listeriosis from different geographical regions in the U.S. ( 29290393 )
2018
2
Clinical management of women with listeriosis risk during pregnancy: a review of national guidelines. ( 29237320 )
2018
3
Prevalence and molecular characteristics of Listeria monocytogenes in cooked products and its comparison with isolates from listeriosis cases. ( 29372499 )
2018
4
Increasing Incidence of Listeriosis and Infection-associated Clinical Outcomes. ( 29214753 )
2018
5
Listeriosis in pregnancy: under-diagnosis despite over-treatment. ( 29022924 )
2018
6
Surveillance of listeriosis in the Tel Aviv District, Israel, 2010-2015. ( 29307320 )
2018
7
Draft Genome Sequences of 510<i>Listeria monocytogenes</i>Strains from Food Isolates and Human Listeriosis Cases from Northern Italy. ( 29348329 )
2018
8
A Comparison of Oral and Intravenous Mouse Models of Listeriosis. ( 29361677 )
2018
9
Erratum: Increasing Incidence of Listeriosis and Infection associated Clinical Outcomes. ( 29401569 )
2018
10
Draft Genome Sequences of 25 Listeria monocytogenes Isolates Associated with Human Clinical Listeriosis in Ireland. ( 28495762 )
2017
11
Hospital-acquired listeriosis linked to a persistently contaminated milkshake machine. ( 28065212 )
2017
12
A clade of Listeria monocytogenes serotype 4b variant strains linked to recent listeriosis outbreaks associated with produce from a defined geographic region in the US. ( 28464038 )
2017
13
Epidemiology and treatment of the commonest form of listeriosis: meningitis and bacteraemia. ( 28956537 )
2017
14
Comparative diagnostic efficacy of recombinant LLO and PI-PLC-based ELISAs for detection of listeriosis in animals. ( 28411150 )
2017
15
Cross-border outbreak of listeriosis caused by cold-smoked salmon, revealed by integrated surveillance and whole genome sequencing (WGS), Denmark and France, 2015 to 2017. ( 29258647 )
2017
16
A nationwide outbreak of listeriosis associated with cold-cuts, Sweden 2013-2014. ( 28649304 )
2017
17
Listeriosis in two twin pregnancies after in vitro fertilization with differential outcome and literature review. ( 29179588 )
2017
18
Epidemiology and Molecular Typing of Pregnancy-Associated Listeriosis Cases in Lombardy, Italy, over a 10-Year Period (2005-2014). ( 28408795 )
2017
19
Genome Sequences of Two Listeria monocytogenes Strains from Nectarines Associated with Listeriosis in 2014. ( 28729255 )
2017
20
Genomic Characterization Helps Dissecting an Outbreak of Listeriosis in Northern Italy. ( 28856063 )
2017
21
Listeriosis during pregnancy. ( 28536811 )
2017
22
Changing US Population Demographics: What Does This Mean for Listeriosis Incidence and Exposure? ( 28632414 )
2017
23
Draft Genome Sequences of Listeria monocytogenes Strains from Listeriosis Outbreaks Linked to Soft Cheese in Washington State. ( 28883140 )
2017
24
Corrigendum for: Pregnancy-related Listeriosis. ( 28861948 )
2017
25
Molecular Tracing to Find Source of Protracted Invasive Listeriosis Outbreak, Southern Germany, 2012-2016. ( 28930013 )
2017
26
GNP-GAPDH1-22 nanovaccines prevent neonatal listeriosis by blocking microglial apoptosis and bacterial dissemination. ( 28903312 )
2017
27
Spontaneous listeriosis in grey mouse lemurs (Microcebus murinus), but not in Goodman's mouse lemurs (Microcebus lehilahytsara) of the same colony. ( 28888657 )
2017
28
Invasive listeriosis in a patient with several episodes of antibiotic associated colitis presumably due to Clostridium difficile. ( 28365900 )
2017
29
Limited Colonization Undermined by Inadequate Early Immune Responses Defines the Dynamics of Decidual Listeriosis. ( 28507070 )
2017
30
Listeria monocytogenes in Food-Processing Facilities, Food Contamination, and Human Listeriosis: The Brazilian Scenario. ( 28767285 )
2017
31
Human Listeriosis Presenting as Breast Abscess: Report of a Rare Case. ( 28289572 )
2017
32
Pregnancy-related listeriosis. ( 28398675 )
2017
33
Burden of salmonellosis, campylobacteriosis and listeriosis: a time series analysis, Belgium, 2012 to 2020. ( 28935025 )
2017
34
Estimating the real incidence of invasive listeriosis through an integrated surveillance model in use in Lombardy (Italy, 2006-2014). ( 28446259 )
2017
35
Enrichment dynamics of Listeria monocytogenes and the associated microbiome from naturally contaminated ice cream linked to a listeriosis outbreak. ( 27852235 )
2016
36
Risk Assessment of Human Listeriosis from Semisoft Cheeses Made from Raw Sheep's Milk in Lazio and Tuscany (Italy). ( 27285819 )
2016
37
Listeriosis downregulates hepatic cytochrome P450 enzymes in sublethal murine infection. ( 27273978 )
2016
38
Ongoing outbreak of invasive listeriosis due to serotype 1/2a Listeria monocytogenes, Ancona province, Italy, January 2015 to February 2016. ( 27168589 )
2016
39
Whole Genome Sequence Analysis Using JSpecies Tool Establishes Clonal Relationships between Listeria monocytogenes Strains from Epidemiologically Unrelated Listeriosis Outbreaks. ( 26950338 )
2016
40
Molecular Typing and Epidemiology of Human Listeriosis Cases, Denmark, 2002-2012(1). ( 26982714 )
2016
41
Draft Genome Sequences of Two Historical Listeria monocytogenes Strains from Human Listeriosis Cases in 1933. ( 27932656 )
2016
42
Fresh Produce-Associated Listeriosis Outbreaks, Sources of Concern, Teachable Moments, and Insights. ( 26818997 )
2016
43
Implementation of Nationwide Real-time Whole-genome Sequencing to Enhance Listeriosis Outbreak Detection and Investigation. ( 27090985 )
2016
44
Trends in US Hospital Stays for Listeriosis in Infants. ( 26980754 )
2016
45
Use of proton pump inhibitors and the risk of listeriosis. A nationwide registry-based case-control study. ( 28013257 )
2016
46
Older Adult Consumer Knowledge, Attitudes, and Self-Reported Storage Practices of Ready-to-Eat Food Products and Risks Associated with Listeriosis. ( 26818987 )
2016
47
Notes from the Field: Outbreak of Listeriosis Associated with Consumption of Packaged Salad - United States and Canada, 2015-2016. ( 27559935 )
2016
48
Oral exposure to Listeria monocytogenes in aged IL-17RKO mice: A possible murine model to study listeriosis in susceptible populations. ( 27574777 )
2016
49
Neonatal listeriosis in the UK 2004-2014. ( 27867063 )
2016
50
Genome Sequences of Listeria monocytogenes Strains Responsible for Cheese- and Cooked Ham Product-Associated Swiss Listeriosis Outbreaks in 2005 and 2011. ( 26966206 )
2016

Variations for Listeriosis

Expression for Listeriosis

Search GEO for disease gene expression data for Listeriosis.

Pathways for Listeriosis

GO Terms for Listeriosis

Biological processes related to Listeriosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.7 IL10 IL6 TNF
2 positive regulation of DNA binding transcription factor activity GO:0051091 9.69 IL10 IL6 TNF
3 defense response to Gram-positive bacterium GO:0050830 9.67 IL6 MBL2 TNF
4 response to organic substance GO:0010033 9.63 CDH1 IL10 TNF
5 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.55 IL10 TNF
6 inflammatory response GO:0006954 9.55 IDO1 IL10 IL6 LXN TNF
7 positive regulation of chemokine production GO:0032722 9.54 IL6 TNF
8 response to glucocorticoid GO:0051384 9.54 IL10 IL6 TNF
9 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 IL10 TNF
10 negative regulation of lipid storage GO:0010888 9.43 IL6 TNF
11 positive regulation of interleukin-6 production GO:0032755 9.43 AKIRIN2 IL6 TNF
12 endothelial cell apoptotic process GO:0072577 9.4 IL10 TNF
13 negative regulation of cytokine secretion involved in immune response GO:0002740 9.32 IL10 TNF
14 receptor biosynthetic process GO:0032800 8.96 IL10 TNF
15 negative regulation of growth of symbiont in host GO:0044130 8.8 IL10 MBL2 TNF

Sources for Listeriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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