MCID: LST001
MIFTS: 62

Listeriosis malady

Infectious diseases category

Summaries for Listeriosis

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Listeriosis is a foodborne illness caused by listeria monocytogenes, bacteria found in soil and water. it can be in a variety of raw foods as well as in processed foods and foods made from unpasteurized milk. listeria is unlike many other germs because it can grow even in the cold temperature of the refrigerator. symptoms include fever and chills, headache, upset stomach and vomiting. treatment is with antibiotics. anyone can get the illness. but it is most likely to affect pregnant women and unborn babies, older adults, and people with weak immune systems. to reduce your risk use precooked and ready-to-eat foods as soon as you can avoid raw milk and raw milk products heat ready-to-eat foods and leftovers until they are steaming hot wash fresh fruits and vegetables avoid rare meat and refrigerated smoked seafood centers for disease control and prevention

MalaCards: Listeriosis, also known as listeria infection, is related to systemic lupus erythematosus and toxoplasmosis, and has symptoms including back pain, malaise and vomiting. An important gene associated with Listeriosis is IDO1 (indoleamine 2,3-dioxygenase 1), and among its related pathways are Cytokines and Inflammatory Response and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds prednisolone and pge2 have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and liver, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A primary bacterial infectious disease that results in infection, has material basis in listeria monocytogenes, which is transmitted by ingestion of contaminated food or raw milk or transmitted by congenital method. ingestion of listeria by pregnant women has symptom nausea, has symptom vomiting, has symptom diarrhea, has symptom fever, has symptom malaise, has symptom back pain, and has symptom headache. maternal infection with listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

CDC:3 Listeriosis, a serious infection usually caused by eating food contaminated with the bacterium Listeria monocytogenes, is an important public health problem in the United States. The disease primarily affects older adults, pregnant women, newborns, and adults with weakened immune systems. However, rarely, persons without these risk factors can also be affected. The risk may be reduced by recommendations for safe food preparation, consumption, and storage.

Wikipedia:63 Listeriosis is a bacterial infection most commonly caused by Listeria monocytogenes, although L.... more...

Aliases & Classifications for Listeriosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 26ICD10 via Orphanet, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
listeriosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

listeriosis 8 10 44 48 60
listeria infection 8 42
infection due to listeria monocytogenes 8
infection by listeria monocytogenes 8
listeriosis, unspecified 8
listeria infections 33
listeriosis nos 8


External Ids:

Disease Ontology8 DOID:11573
NCIt39 C82994
ICD9CM27 027.0
MeSH34 D008088
ICD10 via Orphanet26 A32.7, A32.0, A32.1 A32.8, A32.9, more
MESH via Orphanet35 D008088
SNOMED-CT via Orphanet57 4241002
UMLS via Orphanet61 C0023860
ICD1025 A32, A32.9

Related Diseases for Listeriosis

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17GeneCards, 18GeneDecks
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Diseases related to Listeriosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.4IFNG, MBL2, TNF, CD4, IL6
2toxoplasmosis30.2CD4
3hepatitis30.2CD4
4leukemia30.1IDO1, IFNG, MBL2, TNF, CD4, IL6
5respiratory failure30.0TNF, IL6, ACTA1
6connective tissue disease30.0TNF, CD4, IL6
7meningitis30.0SUMF2, IL6, CD4, MBL2
8otitis media29.8MBL2
9measles29.8CD4
10campylobacteriosis29.8SUMF2
11encephalitis29.8IDO1, CD4
12acute leukemia29.8THY1, CD8A
13thrombocytopenia29.8IL6, CD4
14hepatitis b29.8CD4, MBL2, IFNG
15aspergillosis29.8IFNG, MBL2, CD4
16tuberculosis29.8CD4, TNF, MBL2, IFNG
17multiple sclerosis29.8IDO1, IFNG, MBL2, TNF, CD4, IL6
18lupus erythematosus10.3
19cerebritis10.3
20tularemia10.2
21gastroenteritis10.1
22shigellosis10.0
23chronic lymphocytic leukemia10.0
24secondary syphilis10.0
25syphilis10.0
26dementia10.0IDO1
27autoimmune hepatitis10.0ACTA1
28nephritis10.0THY1
29bronchiectasis10.0MBL2
30rheumatic fever10.0MBL2
31eosinophilia-myalgia syndrome10.0IDO1
32lupus nephritis10.0MBL2
33common variable immune deficiency10.0MBL2
34vitiligo10.0CD8A
35glomerulonephritis10.0MBL2
36bacterial vaginosis10.0MBL2
37lymphatic system disease10.0CD4
38cryptococcosis10.0CD4
39leprosy10.0CD4
40mycobacterium avium complex disease10.0CD4
41kawasaki disease10.0MBL2
42neutropenia10.0MBL2
43gastritis10.0CD4
44herpes zoster10.0CD4
45vaccinia10.0CD4
46liver cirrhosis10.0CD4
47mastitis10.0SUMF2
48mumps10.0CD4
49tropical spastic paraparesis10.0CD4
50chagas disease10.0CD4

Graphical network of the top 20 diseases related to Listeriosis:



Diseases related to listeriosis

Clinical Features for Listeriosis

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 7)
  • back pain
  • malaise
  • vomiting
  • nausea
  • diarrhea
  • headache
  • fever

Drugs & Therapeutics for Listeriosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Listeriosis

Drug clinical trials:

Search ClinicalTrials for Listeriosis

Search NIH Clinical Center for Listeriosis

Search CenterWatch for Listeriosis

Genetic Tests for Listeriosis

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Anatomical Context for Listeriosis

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32MalaCards
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MalaCards organs/tissues related to Listeriosis:

32
Brain, T cells, Liver, Bone marrow, Bone, Placenta, Spleen, Pituitary, Monocytes, Testes, Heart, Nk cells

Animal Models for Listeriosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Listeriosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.2IFNG, MBL2, TNF, BATF3, CD4, CD8A
2MP:00053877.5IL6, IDO1, IFNG, MBL2, TNF, BAHD1

Publications for Listeriosis

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Sources:
50PubMed
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Articles related to Listeriosis:

(show top 50)    (show all 499)
idTitleAuthorsYear
1
Listeriosis during Pregnancy: A Public Health Concern. (24191199)
2013
2
Factor XI-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis. (22006565)
2012
3
Listeriosis outbreak caused by Latin-style fresh cheese, Bizkaia, Spain, August 2012. (23098823)
2012
4
Animal models of listeriosis: a comparative review of the current state of the art and lessons learned. (22417207)
2012
5
Antimicrobial treatment of invasive non-perinatal human listeriosis and the impact of the underlying disease on prognosis. (21851486)
2012
6
Widespread listeriosis outbreak attributable to pasteurized cheese, which led to extensive cross-contamination affecting cheese retailers, Quebec, Canada, 2008. (22221357)
2012
7
A complicated case of cholecystitis, listeriosis and HIV/AIDS. (22715268)
2011
8
Serving high-risk foods in a high-risk setting: survey of hospital food service practices after an outbreak of listeriosis in a hospital. (21460490)
2011
9
Foodborne microbial risks in the press: the framing of listeriosis in Canadian newspapers. (21657136)
2011
10
Listeriosis: a resurgent foodborne infection. (20002687)
2010
11
A fluorescence reporter model defines "Tip-DCs" as the cellular source of interferon I^ in murine listeriosis. (21179567)
2010
12
Pregnancy-associated listeriosis. (20158931)
2010
13
On the lookout for listeriosis. (19543046)
2009
14
Listeriosis. (18977860)
2008
15
Rapid eradication of Listeria monocytogenes by moxifloxacin in a murine model of central nervous system listeriosis. (18573932)
2008
16
Pre-existing anti-Salmonella vector immunity prevents the development of protective antigen-specific CD8 T-cell frequencies against murine listeriosis. (17913544)
2007
17
TNF is important for pathogen control and limits brain damage in murine cerebral listeriosis. (16951360)
2006
18
Changing pattern of human listeriosis, England and Wales, 2001-2004. (17073084)
2006
19
Outbreak of clinical listeriosis in sheep: evaluation from possible contamination routes from feed to raw produce and humans. (16219091)
2005
20
Evaluation of farm management practices as risk factors for clinical listeriosis and fecal shedding of Listeria monocytogenes in ruminants. (16350271)
2005
21
Neutrophilia in LFA-1-deficient mice confers resistance to listeriosis: possible contribution of granulocyte-colony-stimulating factor and IL-17. (12734371)
2003
22
Listeriosis. (12913780)
2003
23
Listeriosis in Iceland, 1978-2000: a description of cases and molecular epidemiology. (12477323)
2002
24
Recombinant lemA without adjuvant induces extensive expansion of H2-M3-restricted CD8 effectors, which can suppress primary listeriosis in mice. (11809741)
2002
25
Protection against murine listeriosis by oral vaccination with recombinant Salmonella expressing hybrid Yersinia type III proteins. (11418671)
2001
26
From the Centers for Disease Control and Prevention. Outbreak of Listeriosis associated with homemade Mexican-style cheese--North Carolina, October 2000-January 2001. (11508310)
2001
27
RAPD analysis, serotyping, and esterase typing indicate that the population of Listeria monocytogenes strains recovered from cheese and from patients with listeriosis in Belgium are different. (11683471)
2001
28
Does administration of infliximab increase susceptibility to listeriosis? (10710107)
2000
29
Stimulatory action of Pluchea quitoc extract on the hematopoietic response during murine listeriosis. (11105784)
2000
30
A small outbreak of listeriosis potentially linked to the consumption of imitation crab meat. (10972708)
2000
31
Early host-pathogen interactions in the liver and spleen during systemic murine listeriosis: an overview. (10631566)
1999
32
Kinetics of interferon-gamma production and its comparison with anti-listeriolysin O detection in experimental bovine listeriosis. (10066124)
1998
33
Macrophages and hepatocytic cells as chemokine producers in murine listeriosis. (9717670)
1998
34
Comprehensive study of the intestinal stage of listeriosis in a rat ligated ileal loop system. (9453636)
1998
35
Culture-negative listeriosis of the central nervous system diagnosed by detection of antibodies to listeriolysin O. (9105851)
1997
36
Clinafloxacin (CL 960) is superior to standard therapeutics in the treatment of murine listeriosis and salmonellosis. (9361386)
1997
37
Listeriosis: an opportunistic infection. (9492404)
1997
38
Evidence for the early recruitment of T-cell receptor gamma delta+ T cells during rat listeriosis. (8666431)
1996
39
Verification of causal relationships between Listeria monocytogenes isolates implicated in food-borne outbreaks of listeriosis by randomly amplified polymorphic DNA patterns. (8051257)
1994
40
Risk factors for listeriosis in Denmark, 1989-1990. (8036473)
1994
41
Neutrophils as effector cells of T-cell-mediated, acquired immunity in murine listeriosis. (7835951)
1994
42
Perinatal listeriosis in a Dutch woman returning from holiday in France. (8187925)
1994
43
First trimester listeriosis with normal fetal outcome. (7813496)
1994
44
Listeriosis update. (7693180)
1993
45
Listeriosis of the placenta: clinicopathologic study of seven cases. (8372871)
1993
46
Listeriosis in California broiler chickens. (1515498)
1992
47
Listeriosis surveillance: 1991. (1284938)
1992
48
Serological evidence for culture-negative listeriosis of central nervous system. (1354320)
1992
49
Multilocus enzyme electrophoresis - Application to the study of meningococcal meningitis and listeriosis. (22553459)
1990
50
Models of T cell deficiency in listeriosis: the effects of cortisone and cyclosporin A on normal and nude BALB/c mice. (6602835)
1983

Genetic Variations for Listeriosis

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Expression for genes affiliated with Listeriosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Listeriosis

Search GEO for disease gene expression data for Listeriosis.

Pathways for genes affiliated with Listeriosis

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 52R&D Systems, 29KEGG, 4Cell Signaling Technology, 53Reactome
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Pathways related to Listeriosis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CD4
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.2IFNG
3
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10.0CD4, IFNG
4
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9.9CD4, IL6
59.9IL6, TNF
6
Hide members
9.7IFNG, CD4, CD8A
79.7IFNG, TNF, ACTA1
89.7CD8A, TNF, IFNG
9
Immune response Bacterial infections in normal airways
9.6IL6, TNF, IFNG
10
Hide members
9.6IFNG, TNF, IL6
119.6IL6, TNF, IFNG
129.6IL6, TNF, IFNG
139.6IFNG, TNF, IL6
149.6IL6, TNF, IFNG
15
Hide members
9.5IFNG, TNF, BATF3
169.4IL6, TNF, IFNG, IDO1
179.4TNF, CD4, CD8A, IL6
189.4THY1, IL6, TNF
19
Hide members
9.4IFNG, TNF, CD4, IL6
20
Development PDGF signaling via STATs and NF-kB
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9.4IFNG, TNF, CD4, IL6
219.2THY1, CD8A, CD4, IDO1
22
Hide members
9.1IFNG, TNF, CD4, CD8A, IL6
23
Hide members
9.1IL6, CD8A, CD4, TNF, IFNG
24
Hide members
8.8KLRG1, IFNG, MBL2, CD4, CD8A, IL6

Compounds for genes affiliated with Listeriosis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Listeriosis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1prednisolone44 28 1112.7MBL2
2pge24410.6CD4
3cycloheximide4410.5CD4
41-methyltryptophan4410.4IFNG, IDO1
5gm-csf44 2811.3IFNG, TNF
63-hydroxyanthranilic acid44 2411.3IFNG, IDO1
7tocilizumab44 1111.3IL6, TNF
8abatacept44 1111.3IL6, TNF
9cdp5714410.2IL6, TNF
10interferon gamma4410.2TNF, IFNG
11bucillamine4410.2IL6, IFNG
12kynurenine4410.1IDO1, IFNG
13anakinra44 1111.1IL6, TNF
14taurine chloramine4410.1IFNG, TNF, IL6
15lipoteichoic acid4410.1IL6, TNF, MBL2
16l-nmma4410.1IDO1, IFNG, TNF
17vesnarinone4410.1IFNG, TNF, IL6
18herbimycin a44 5911.0IFNG, TNF, CD4
19dexamethasone44 49 28 1113.0IL6, IDO1
20adalimumab44 49 1112.0IFNG, TNF, IL6
21il-124410.0IL6, TNF, IFNG
22imiquimod44 28 59 1113.0IFNG, TNF, IL6
23okt34410.0IL6, TNF, IFNG
24triptolide4410.0IFNG, TNF, IL6
25parthenolide44 211.0IL6, TNF, IFNG
26polyinosinic-polycytidylic acid4410.0IL6, TNF, IFNG
27etanercept44 49 1112.0IFNG, TNF, IL6
28gabexate mesilate4410.0TNF, IL6
29tarc4410.0CD4, TNF, IFNG
30ivig4410.0IFNG, TNF, IL6
31ccl344 2811.0IL6, TNF, IFNG
32melphalan44 1110.9IL6, TNF, IFNG
3315-deoxy-delta-12,14-prostaglandin j2449.9IFNG, TNF, IL6
34gold sodium thiomalate449.9TNF, IFNG
35mip 1alpha449.9IL6, TNF
36pdtc449.9IFNG, TNF, IL6
37peptidoglycan44 2810.9ACTA1, IL6, TNF, MBL2
38thalidomide44 49 59 1112.9IL6, TNF, IFNG
392,5-oligoadenylate449.9IDO1, IFNG, TNF, IL6
40poly(i-c)449.9IL6, TNF, IFNG, IDO1
41infliximab44 49 1111.8IDO1, IFNG, TNF, IL6
42polymyxin b449.8IL6, TNF, MBL2, IFNG
43lactacystin449.8CD4, TNF, IFNG
44il 10449.8IFNG, TNF, CD8A, IL6
45tuberculin449.7MBL2, IFNG
46neopterin449.4IL6, CD4, TNF, MBL2, IFNG, IDO1
47rantes449.4IDO1, IFNG, MBL2, TNF, CD4, IL6
48lipid448.6MBL2, TNF, CD4, IL6, THY1, ACTA1
49tyrosine448.3IDO1, MBL2, CD4, CD8A, IL6, KIR2DS4

GO Terms for genes affiliated with Listeriosis

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16Gene Ontology
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Cellular components related to Listeriosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T cell receptor complexGO:04210110.0CD8A, CD4
2external side of plasma membraneGO:0098978.3THY1, IL6, CD8A, CD4, TNF, IFNG

Biological processes related to Listeriosis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:06055710.2TNF, IFNG
2neutrophil apoptotic processGO:00178110.2IFNG, IL6
3positive regulation of calcidiol 1-monooxygenase activityGO:06055910.2IFNG, TNF
4negative regulation of lipid storageGO:01088810.1IL6, TNF
5epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.1IL6, TNF
6positive regulation of chemokine biosynthetic processGO:04508010.1IFNG, TNF
7negative regulation of growth of symbiont in hostGO:04413010.0IFNG, MBL2, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:05104410.0IFNG, TNF
9positive regulation of nitric oxide biosynthetic processGO:0454299.9IFNG, TNF, IL6
10acute-phase responseGO:0069539.9IL6, REG3G, MBL2
11response to mechanical stimulusGO:0096129.9TNF, IL6, ACTA1
12positive regulation of chemokine productionGO:0327229.9TNF, IL6
13humoral immune responseGO:0069599.9IL6, TNF, IFNG
14positive regulation of osteoclast differentiationGO:0456729.8TNF, IFNG
15defense response to Gram-positive bacteriumGO:0508309.6IL6, REG3G, TNF, MBL2
16defense response to protozoanGO:0428329.6IFNG, IL6
17response to virusGO:0096159.5BATF3, TNF, IFNG
18inflammatory responseGO:0069549.3IL6, LXN, TNF, KLRG1

Products for genes affiliated with Listeriosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Listeriosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet