MCID: LVR002
MIFTS: 43

Liver Angiosarcoma malady

Categories: Rare diseases, Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Liver Angiosarcoma

Aliases & Descriptions for Liver Angiosarcoma:

Name: Liver Angiosarcoma 12 14
Angiosarcoma of Liver 12 69
Hemangiosarcoma of the Liver 12
Angiosarcoma of the Liver 50

Classifications:



External Ids:

Disease Ontology 12 DOID:268
ICD10 33 C22.3
NCIt 47 C4438
SNOMED-CT 64 109844006 187770005
UMLS 69 C0345907

Summaries for Liver Angiosarcoma

Disease Ontology : 12 An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located in the liver.

MalaCards based summary : Liver Angiosarcoma, also known as angiosarcoma of liver, is related to unknown leukodystrophy and pseudomonas stutzeri infections. An important gene associated with Liver Angiosarcoma is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Glioma. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and the liver, and related phenotypes are cardiovascular system and cellular

Related Diseases for Liver Angiosarcoma

Diseases related to Liver Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
id Related Disease Score Top Affiliating Genes
1 unknown leukodystrophy 10.3 KRT19 VIM
2 pseudomonas stutzeri infections 10.3 KRAS NRAS
3 malignant skin fibrous histiocytoma 10.3 HRAS KRAS
4 rommen mueller sybert syndrome 10.3 CDK4 TP53
5 benign schwannoma 10.2 ENO2 VIM
6 chest wall parachordoma 10.2 CD34 VIM
7 osteomyelitis 10.2 CDK4 VIM
8 rdh12-related leber congenital amaurosis 10.2 KRAS NRAS
9 secondary corneal edema 10.2 CYP2E1 KRT19 TP53
10 angiosarcoma 10.2
11 chronic venous insufficiency 10.2 HRAS KRAS
12 pancreatic cystadenoma 10.2 KRAS KRT19 TP53
13 severe pre-eclampsia 10.2 HRAS KRAS
14 arteriosclerosis obliterans 10.2 CD34 TP53
15 human granulocytic anaplasmosis 10.2 TP53 VIM VWF
16 retina lymphoma 10.2 HRAS KRAS KRT19
17 erythrocyte lactate transporter defect 10.2 HRAS KRAS NRAS
18 melanocytic nevus syndrome, congenital, somatic 10.2 HRAS KRAS NRAS
19 enchondromatosis dwarfism deafness 10.2 CDK4 TP53 VIM
20 nutritional deficiency disease 10.2 CD34 VIM
21 gastroesophageal junction adenocarcinoma 10.2 KRAS KRT19 TP53
22 spongiotic dermatitis 10.2 HRAS KRAS NRAS
23 growth retardation hydrocephaly lung hypoplasia 10.2 ENO2 TP53 VIM
24 infertility 10.2 HRAS KRT19 NRAS
25 familial hyperaldosteronism 10.2 HRAS KRAS NRAS
26 childhood brain germinoma 10.2 ENO2 TP53 VIM
27 clear cell adenofibroma 10.2 CDKN2A TP53
28 uterine corpus endometrial stromal sarcoma 10.2 HRAS KRAS TP53
29 tabes dorsalis 10.2 HRAS KRAS TP53
30 breast ductal carcinoma 10.2 KRAS TP53
31 central nervous system hemangioma 10.2 ENO2 TP53 VIM
32 arthus reaction 10.2 HRAS KRAS TP53
33 lacrimal gland adenoid cystic carcinoma 10.2 CDKN2A TP53
34 plasmacytoma 10.2 HRAS KRAS TP53
35 acute hemorrhagic encephalitis 10.2 HRAS NRAS
36 ideomotor apraxia 10.1 HRAS KRAS TP53
37 pleomorphic adenoma 10.1 CD34 HBA1
38 dental caries 10.1 HRAS KRAS TP53
39 nasal cavity disease 10.1 HRAS KRAS TP53
40 pericardium leiomyoma 10.1 CDKN2A TP53
41 basophil adenoma 10.1 CD34 HBA1
42 vascular hemostatic disease 10.1 ENO2 HRAS KRAS
43 congenital symblepharon 10.1 HRAS KRAS TP53
44 cavernous hemangioma of colon 10.1 CD34 ENO2
45 medullary cystic kidney disease 1 10.1 HRAS KRAS NRAS
46 oral squamous cell carcinoma 10.1 HRAS KRAS TP53
47 ovarian lymphoma 10.1 CD34 HBA1
48 joubert syndrome 18 10.1 HRAS KRAS NRAS
49 sarcocystosis 10.1 CD34 HBA1
50 thyroid angiosarcoma 10.1 CD34 HBA1

Graphical network of the top 20 diseases related to Liver Angiosarcoma:



Diseases related to Liver Angiosarcoma

Symptoms & Phenotypes for Liver Angiosarcoma

MGI Mouse Phenotypes related to Liver Angiosarcoma:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.22 VIM NRAS VWF TP53 KRT19 HRAS
2 cellular MP:0005384 10.21 VIM NRAS VWF TP53 KRT19 CDKN2A
3 behavior/neurological MP:0005386 10.19 VIM NRAS KRAS TP53 HRAS CDKN2A
4 homeostasis/metabolism MP:0005376 10.16 VIM NRAS VWF KRAS TP53 CDK4
5 mortality/aging MP:0010768 10.07 TP53 KRT19 VIM NRAS KRAS CDK4
6 digestive/alimentary MP:0005381 10.04 KRT19 NRAS VWF TP53 CDKN2A KRAS
7 integument MP:0010771 10.03 NRAS TP53 KRT19 HRAS CDKN2A KRAS
8 embryo MP:0005380 10.02 KRT19 VIM NRAS KRAS TP53 CDK4
9 neoplasm MP:0002006 9.97 NRAS TP53 KRT19 HRAS CDKN2A KRAS
10 nervous system MP:0003631 9.91 KRT19 VIM VWF KRAS TP53 CDK4
11 liver/biliary system MP:0005370 9.88 TP53 NRAS KRAS CDK4 CDKN2A CYP2E1
12 no phenotypic analysis MP:0003012 9.7 KRT19 NRAS VWF TP53 HRAS CDKN2A
13 pigmentation MP:0001186 9.35 NRAS TP53 CDKN2A KRAS CDK4
14 respiratory system MP:0005388 9.1 TP53 VIM KRAS HRAS CDKN2A ENO2

Drugs & Therapeutics for Liver Angiosarcoma

Drugs for Liver Angiosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3 3778-73-2 3690
3
Mechlorethamine Approved Phase 3 51-75-2 4033
4
Doxil Approved June 1999 Phase 3,Phase 1 31703
5 Alkylating Agents Phase 3
6 Anti-Bacterial Agents Phase 3,Phase 1
7 Antibiotics, Antitubercular Phase 3,Phase 1
8 Antineoplastic Agents, Alkylating Phase 3
9 Isophosphamide mustard Phase 3
10 Topoisomerase Inhibitors Phase 3,Phase 1
11 Antibodies Phase 1
12 Antibodies, Monoclonal Phase 1
13 Immunoglobulins Phase 1
14 Liver Extracts

Interventional clinical trials:


id Name Status NCT ID Phase
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Unknown status NCT00346164 Phase 3
2 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1
3 Identification, Molecular Epidemiology Angiosarcoma of the Liver France Active, not recruiting NCT01786889
4 Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation Not yet recruiting NCT03025438

Search NIH Clinical Center for Liver Angiosarcoma

Genetic Tests for Liver Angiosarcoma

Anatomical Context for Liver Angiosarcoma

MalaCards organs/tissues related to Liver Angiosarcoma:

39
Liver, Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Liver Angiosarcoma:

18
The Liver

Publications for Liver Angiosarcoma

Articles related to Liver Angiosarcoma:

(show all 18)
id Title Authors Year
1
Liver Angiosarcoma: Rare tumour associated with a poor prognosis, literature review and case report. ( 27718433 )
2016
2
Sequential development of hepatocellular carcinoma and liver angiosarcoma in a vinyl chloride-exposed worker. ( 27544804 )
2016
3
Liver angiosarcoma, a rare liver malignancy, presented with intraabdominal bleeding due to rupture--a case report. ( 22280556 )
2012
4
Widening spectrum of liver angiosarcoma in children. ( 21832953 )
2011
5
Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride. ( 12211074 )
2002
6
Establishment and characterization of a spontaneously immortalized myofibroblast cell line derived from a human liver angiosarcoma. ( 10952247 )
2000
7
Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer. ( 10964802 )
2000
8
Diffuse liver angiosarcoma and cerebral cavernous angiomas in a young patient. ( 10692780 )
1999
9
Two new cases of liver angiosarcoma: history and perspectives of liver angiosarcoma among plastic industry workers. ( 9284534 )
1997
10
Vinylchloride monomer exposure by the plastic industry workers basic condition for liver angiosarcoma appearance. ( 9277092 )
1996
11
Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure. ( 1793483 )
1991
12
Invasive character of malignant endothelial cells in vinyl-chloride-induced liver angiosarcoma. ( 2381457 )
1990
13
Massive bleeding after fine needle aspiration of liver angiosarcoma. ( 2298353 )
1990
14
Liver angiosarcoma in a vinyl chloride polymerization plant worker. Report of the seventh Italian case. ( 3173221 )
1988
15
Iatrogenic disease. Lipoid pneumonia and liver angiosarcoma. ( 3714604 )
1986
16
Two cases of liver angiosarcoma among polyvinyl chloride (PVC) extruders of an Italian factory producing PVC bags and other containers. ( 6539068 )
1984
17
Persistence of DNA damage during development of liver angiosarcoma in rats fed dimethylnitrosamine. ( 570883 )
1979
18
Log normal distribution of the incubation period of liver angiosarcoma in vinyl chloride polymerization workers. ( 569691 )
1979

Variations for Liver Angiosarcoma

Expression for Liver Angiosarcoma

Search GEO for disease gene expression data for Liver Angiosarcoma.

Pathways for Liver Angiosarcoma

Pathways related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 HRAS KRAS NRAS TP53 VIM VWF
2
Show member pathways
13 CDK4 CDKN2A HRAS KRAS NRAS TP53
3
Show member pathways
12.88 CDK4 HRAS KRAS NRAS TP53
4
Show member pathways
12.8 CDKN2A HRAS KRAS NRAS TP53
5
Show member pathways
12.63 HRAS KRAS NRAS TP53
6 12.6 CDK4 CDKN2A HRAS KRAS NRAS TP53
7
Show member pathways
12.56 HRAS KRAS NRAS TP53
8
Show member pathways
12.53 HRAS KRAS NRAS TP53
9
Show member pathways
12.49 HRAS KRAS NRAS TP53
10 12.48 CDK4 CDKN2A TP53 VIM
11 12.47 CDK4 HRAS KRAS NRAS TP53 VWF
12
Show member pathways
12.43 HRAS KRAS NRAS TP53
13
Show member pathways
12.41 CDK4 HRAS KRAS NRAS
14 12.39 CDKN2A HRAS KRAS NRAS TP53 VIM
15
Show member pathways
12.38 CDK4 HRAS KRAS NRAS VIM
16
Show member pathways
12.35 HRAS KRAS NRAS TP53
17
Show member pathways
12.35 HRAS KRAS NRAS TP53
18
Show member pathways
12.3 HRAS KRAS NRAS TP53
19 12.29 HRAS KRAS NRAS TP53
20
Show member pathways
12.29 HRAS KRAS NRAS VWF
21
Show member pathways
12.26 HRAS KRAS NRAS TP53
22 12.25 CDK4 CDKN2A HRAS KRAS NRAS TP53
23
Show member pathways
12.18 HRAS KRAS NRAS TP53
24
Show member pathways
12.15 HRAS KRAS NRAS TP53
25
Show member pathways
12.14 HRAS KRAS NRAS TP53
26 12.11 HRAS KRAS NRAS TP53
27
Show member pathways
12.09 HRAS KRAS NRAS VWF
28 12.07 CDK4 CDKN2A KRAS TP53
29
Show member pathways
12.06 CDK4 HRAS KRAS NRAS
30 12.05 HRAS KRAS NRAS TP53
31 12.04 CDK4 CDKN2A HRAS KRAS NRAS TP53
32
Show member pathways
12.03 HRAS KRAS NRAS
33 12.02 HRAS KRAS NRAS
34
Show member pathways
12 HRAS KRAS NRAS
35 12 HRAS KRAS NRAS
36 11.99 CDK4 TP53 VIM
37 11.98 HRAS KRAS NRAS TP53
38 11.96 HRAS KRAS NRAS
39 11.96 HRAS KRAS NRAS TP53
40 11.93 HRAS KRAS NRAS
41
Show member pathways
11.93 HRAS KRAS NRAS
42 11.92 CDKN2A HRAS TP53
43 11.87 CDK4 HRAS KRAS NRAS
44
Show member pathways
11.86 HRAS KRAS NRAS
45 11.86 CDKN2A HRAS KRAS NRAS TP53
46
Show member pathways
11.85 HRAS KRAS NRAS
47 11.83 HRAS KRAS NRAS
48
Show member pathways
11.8 HRAS KRAS NRAS
49
Show member pathways
11.78 CDK4 CDKN2A HRAS KRAS NRAS TP53
50
Show member pathways
11.68 HRAS KRAS NRAS

GO Terms for Liver Angiosarcoma

Biological processes related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.67 CD34 HRAS KRAS NRAS
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.65 HRAS KRAS NRAS
3 regulation of long-term neuronal synaptic plasticity GO:0048169 9.49 HRAS KRAS
4 replicative senescence GO:0090399 9.46 CDKN2A TP53
5 response to isolation stress GO:0035900 9.43 HRAS KRAS
6 epidermal growth factor receptor signaling pathway GO:0007173 9.43 HRAS KRAS NRAS
7 positive regulation of cellular senescence GO:2000774 9.4 CDKN2A KRAS
8 positive regulation of gene expression GO:0010628 9.35 CD34 HRAS KRAS TP53 VIM
9 ERBB2 signaling pathway GO:0038128 9.33 HRAS KRAS NRAS
10 heterocycle metabolic process GO:0046483 9.32 CYP2E1 UGT1A1
11 Ras protein signal transduction GO:0007265 9.02 CDKN2A HRAS KRAS NRAS TP53

Molecular functions related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex binding GO:0032403 8.92 CDK4 KRAS KRT19 NRAS

Sources for Liver Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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