MCID: LVR002
MIFTS: 45

Liver Angiosarcoma

Categories: Rare diseases, Liver diseases, Cancer diseases

Aliases & Classifications for Liver Angiosarcoma

MalaCards integrated aliases for Liver Angiosarcoma:

Name: Liver Angiosarcoma 12 14
Angiosarcoma of the Liver 72 49
Angiosarcoma of Liver 12 69
Hemangiosarcoma of the Liver 12
Hepatic Angiosarcoma 36

Classifications:



External Ids:

Disease Ontology 12 DOID:268
ICD10 32 C22.3
NCIt 46 C4438
SNOMED-CT 64 109844006 187770005
KEGG 36 H01557
UMLS 69 C0345907

Summaries for Liver Angiosarcoma

Disease Ontology : 12 An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located in the liver.

MalaCards based summary : Liver Angiosarcoma, also known as angiosarcoma of the liver, is related to angiosarcoma and hepatocellular carcinoma. An important gene associated with Liver Angiosarcoma is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and the liver, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 72 Angiosarcoma is a cancer of the cells that line the walls of blood vessels or lymphatic vessels. The... more...

Related Diseases for Liver Angiosarcoma

Diseases related to Liver Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 30.8 TP53 VIM VWF
2 hepatocellular carcinoma 27.8 CD34 CDK4 CYP2E1 HRAS KRAS KRT19
3 regional odontodysplasia 10.6 KRT19 VIM
4 histiocytoid hemangioma 10.5 CAMTA1 HBA1
5 anal canal adenocarcinoma 10.5 KRAS KRT19
6 adenoid squamous cell carcinoma 10.5 HBA1 VIM
7 hyperplastic polyposis syndrome 10.4 KRAS TP53
8 hepatitis 10.4
9 bednar tumor 10.4 ENO2 VIM
10 sigmoid neoplasm 10.4 HRAS KRAS
11 primitive neuroectodermal tumor of the cervix uteri 10.4 ENO2 VIM
12 spindle cell lipoma 10.4 CDK4 VIM
13 glomangiomyoma 10.4 CD34 VIM
14 apocrine adenoma 10.4 HRAS KRAS
15 papillary tumor of the pineal region 10.4 ENO2 VIM
16 periampullary adenoma 10.4 HRAS KRAS
17 sternum cancer 10.4 CD34 VIM
18 ring chromosome 7 10.4 CDK4 TP53
19 epulis 10.4 ENO2 VIM
20 ovary sarcoma 10.3 CD34 HBA1
21 ovarian angiosarcoma 10.3 CD34 HBA1
22 paronychia 10.3 HRAS KRAS
23 intravascular fasciitis 10.3 CD34 HBA1
24 pediatric angiosarcoma 10.3 CD34 HBA1
25 thyroid angiosarcoma 10.3 CD34 HBA1
26 mutyh-associated polyposis 10.3 KRAS TP53
27 pinguecula 10.3 CYP2E1 KRT19 TP53
28 ossifying fibromyxoid tumor 10.3 ENO2 VIM
29 infiltrating angiolipoma 10.3 CDK4 VWF
30 intrahepatic cholangiocarcinoma 10.3 KRAS KRT19 TP53
31 neurogenic arthropathy 10.3 CD34 HBA1
32 syringocystadenoma papilliferum 10.3 KRAS VIM
33 epithelioid leiomyosarcoma 10.3 ENO2 VIM
34 vascular cancer 10.3 CAMTA1 HBA1 VWF
35 benign struma ovarii 10.3 HRAS NRAS
36 bone epithelioid hemangioma 10.3 CD34 HBA1
37 thyroid sarcoma 10.3 CD34 HBA1
38 hobnail hemangioma 10.3 CD34 HBA1
39 cellular neurofibroma 10.3 CD34 TP53
40 colloid carcinoma of the pancreas 10.3 HRAS KRAS KRT19
41 glomeruloid hemangioma 10.2 CD34 HBA1
42 meninges sarcoma 10.2 CD34 TP53
43 schimmelpenning-feuerstein-mims syndrome 10.2 HRAS KRAS NRAS
44 ovarian melanoma 10.2 HRAS NRAS
45 pericardium cancer 10.2 ENO2 HBA1 KRT19
46 nevus, epidermal 10.2 HRAS KRAS NRAS
47 embryonal sarcoma 10.2 CDK4 TP53 VIM
48 spitz nevus 10.2 HRAS TP53
49 acneiform dermatitis 10.2 HRAS KRAS NRAS
50 malignant struma ovarii 10.2 HRAS KRT19 NRAS

Graphical network of the top 20 diseases related to Liver Angiosarcoma:



Diseases related to Liver Angiosarcoma

Symptoms & Phenotypes for Liver Angiosarcoma

MGI Mouse Phenotypes related to Liver Angiosarcoma:

43 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.3 HRAS CDK4 KRAS CYP2E1 CAMTA1 ENO2
2 cardiovascular system MP:0005385 10.29 CDK4 KRAS CYP2E1 HRAS WWTR1 YAP1
3 cellular MP:0005384 10.28 CDK4 KRAS ENO2 CD34 WWTR1 VIM
4 growth/size/body region MP:0005378 10.24 HRAS CDK4 CAMTA1 ENO2 WWTR1 YAP1
5 homeostasis/metabolism MP:0005376 10.22 HRAS CDK4 CYP2E1 CD34 VWF WWTR1
6 digestive/alimentary MP:0005381 10.18 CDK4 KRAS HRAS WWTR1 YAP1 VWF
7 mortality/aging MP:0010768 10.18 HRAS CDK4 KRAS CYP2E1 CAMTA1 WWTR1
8 immune system MP:0005387 10.16 CDK4 CD34 WWTR1 VIM YAP1 VWF
9 endocrine/exocrine gland MP:0005379 10.11 HRAS CDK4 WWTR1 YAP1 KRT19 TP53
10 integument MP:0010771 10.09 HRAS CDK4 KRAS CD34 YAP1 KRT19
11 neoplasm MP:0002006 10.02 KRAS CYP2E1 CAMTA1 CD34 HRAS CDK4
12 nervous system MP:0003631 9.96 HRAS CDK4 CAMTA1 ENO2 VIM YAP1
13 liver/biliary system MP:0005370 9.95 CDK4 CYP2E1 WWTR1 YAP1 TP53 NRAS
14 normal MP:0002873 9.76 HRAS CDK4 CAMTA1 KRT19 TP53 NRAS
15 pigmentation MP:0001186 9.35 CDK4 TP53 NRAS KRAS TFE3
16 respiratory system MP:0005388 9.17 HRAS ENO2 WWTR1 VIM YAP1 TP53

Drugs & Therapeutics for Liver Angiosarcoma

Drugs for Liver Angiosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation Completed NCT03025438
2 Identification, Molecular Epidemiology Angiosarcoma of the Liver France Active, not recruiting NCT01786889

Search NIH Clinical Center for Liver Angiosarcoma

Genetic Tests for Liver Angiosarcoma

Anatomical Context for Liver Angiosarcoma

MalaCards organs/tissues related to Liver Angiosarcoma:

38
Liver, Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Liver Angiosarcoma:

18
The Liver

Publications for Liver Angiosarcoma

Articles related to Liver Angiosarcoma:

(show all 18)
# Title Authors Year
1
Liver Angiosarcoma: Rare tumour associated with a poor prognosis, literature review and case report. ( 27718433 )
2016
2
Sequential development of hepatocellular carcinoma and liver angiosarcoma in a vinyl chloride-exposed worker. ( 27544804 )
2016
3
Liver angiosarcoma, a rare liver malignancy, presented with intraabdominal bleeding due to rupture--a case report. ( 22280556 )
2012
4
Widening spectrum of liver angiosarcoma in children. ( 21832953 )
2011
5
Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride. ( 12211074 )
2002
6
Establishment and characterization of a spontaneously immortalized myofibroblast cell line derived from a human liver angiosarcoma. ( 10952247 )
2000
7
Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer. ( 10964802 )
2000
8
Diffuse liver angiosarcoma and cerebral cavernous angiomas in a young patient. ( 10692780 )
1999
9
Two new cases of liver angiosarcoma: history and perspectives of liver angiosarcoma among plastic industry workers. ( 9284534 )
1997
10
Vinylchloride monomer exposure by the plastic industry workers basic condition for liver angiosarcoma appearance. ( 9277092 )
1996
11
Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure. ( 1793483 )
1991
12
Massive bleeding after fine needle aspiration of liver angiosarcoma. ( 2298353 )
1990
13
Invasive character of malignant endothelial cells in vinyl-chloride-induced liver angiosarcoma. ( 2381457 )
1990
14
Liver angiosarcoma in a vinyl chloride polymerization plant worker. Report of the seventh Italian case. ( 3173221 )
1988
15
Iatrogenic disease. Lipoid pneumonia and liver angiosarcoma. ( 3714604 )
1986
16
Two cases of liver angiosarcoma among polyvinyl chloride (PVC) extruders of an Italian factory producing PVC bags and other containers. ( 6539068 )
1984
17
Log normal distribution of the incubation period of liver angiosarcoma in vinyl chloride polymerization workers. ( 569691 )
1979
18
Persistence of DNA damage during development of liver angiosarcoma in rats fed dimethylnitrosamine. ( 570883 )
1979

Variations for Liver Angiosarcoma

Expression for Liver Angiosarcoma

Search GEO for disease gene expression data for Liver Angiosarcoma.

Pathways for Liver Angiosarcoma

Pathways related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 CDK4 HRAS KRAS NRAS TP53 VWF
2 12.83 CDK4 HRAS KRAS NRAS TP53
3
Show member pathways
12.76 CDK4 HRAS KRAS NRAS TP53
4
Show member pathways
12.59 HRAS KRAS NRAS TP53 YAP1
5
Show member pathways
12.57 CDK4 HRAS KRAS NRAS TP53
6
Show member pathways
12.56 CDK4 HRAS KRAS NRAS TP53
7 12.5 HRAS KRAS NRAS TP53 VIM
8
Show member pathways
12.49 HRAS KRAS NRAS TP53
9
Show member pathways
12.48 HRAS KRAS NRAS TP53
10
Show member pathways
12.43 HRAS KRAS NRAS TP53
11
Show member pathways
12.43 HRAS KRAS NRAS TFE3 TP53
12
Show member pathways
12.41 CDK4 HRAS KRAS NRAS
13
Show member pathways
12.36 HRAS KRAS NRAS TP53
14
Show member pathways
12.35 CDK4 HRAS KRAS NRAS VIM
15 12.33 CDK4 HRAS KRAS NRAS TP53
16 12.3 HRAS KRAS NRAS TP53
17
Show member pathways
12.3 HRAS KRAS NRAS VWF
18
Show member pathways
12.26 HRAS KRAS NRAS TP53
19
Show member pathways
12.2 CDK4 HRAS KRAS NRAS TP53
20
Show member pathways
12.18 HRAS KRAS NRAS TP53
21
Show member pathways
12.15 HRAS KRAS NRAS TP53
22
Show member pathways
12.14 HRAS KRAS NRAS TP53
23 12.13 CDK4 HRAS KRAS NRAS TP53
24
Show member pathways
12.08 HRAS KRAS NRAS VWF
25
Show member pathways
12.06 CDK4 HRAS KRAS NRAS
26
Show member pathways
12.05 HRAS KRAS NRAS TP53
27 12.05 HRAS KRAS NRAS TP53
28 11.98 HRAS KRAS NRAS TP53
29 11.96 HRAS KRAS NRAS TP53
30 11.94 HRAS KRAS NRAS TP53
31 11.92 CDK4 HRAS KRAS NRAS TP53
32
Show member pathways
11.89 HRAS KRAS NRAS YAP1
33
Show member pathways
11.86 HRAS KRAS NRAS
34
Show member pathways
11.85 HRAS KRAS NRAS
35
Show member pathways
11.84 CDK4 HRAS KRAS NRAS TP53
36 11.83 HRAS KRAS NRAS
37 11.81 CDK4 HRAS KRAS NRAS
38
Show member pathways
11.8 HRAS KRAS NRAS
39
Show member pathways
11.68 HRAS KRAS NRAS
40 11.64 HRAS KRAS NRAS
41 11.61 HRAS KRAS NRAS
42 11.6 CDK4 HRAS KRAS NRAS TP53
43 11.54 HRAS KRAS NRAS
44 11.52 HRAS KRAS NRAS TP53
45 11.47 HRAS KRAS NRAS
46 11.34 HRAS KRAS NRAS
47 11.26 HRAS KRAS NRAS
48 11.25 HRAS KRAS NRAS
49 11.22 CDK4 HRAS KRAS NRAS TP53
50
Show member pathways
11.21 HRAS KRAS NRAS

GO Terms for Liver Angiosarcoma

Cellular components related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.73 CAMTA1 CDK4 ENO2 HBA1 HRAS KRAS
2 transcription factor complex GO:0005667 8.92 CDK4 TP53 WWTR1 YAP1

Biological processes related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.99 CAMTA1 HRAS TFE3 TP53 WWTR1 YAP1
2 positive regulation of cell proliferation GO:0008284 9.88 CDK4 HRAS KRAS WWTR1 YAP1
3 response to drug GO:0042493 9.8 CDK4 CYP2E1 TP53 UGT1A1
4 leukocyte migration GO:0050900 9.73 CD34 HRAS KRAS NRAS
5 positive regulation of gene expression GO:0010628 9.65 CD34 HRAS KRAS TP53 VIM
6 epidermal growth factor receptor signaling pathway GO:0007173 9.54 HRAS KRAS NRAS
7 response to isolation stress GO:0035900 9.46 HRAS KRAS
8 heterocycle metabolic process GO:0046483 9.4 CYP2E1 UGT1A1
9 ERBB2 signaling pathway GO:0038128 9.33 HRAS KRAS NRAS
10 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.32 WWTR1 YAP1
11 cellular response to gamma radiation GO:0071480 9.13 HRAS TP53 YAP1
12 Ras protein signal transduction GO:0007265 8.92 HRAS KRAS NRAS TP53

Molecular functions related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein complex binding GO:0032403 9.26 CDK4 KRAS KRT19 NRAS
2 protein C-terminus binding GO:0008022 8.92 HRAS TP53 VIM YAP1

Sources for Liver Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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