MCID: LVR002
MIFTS: 39

Liver Angiosarcoma

Categories: Rare diseases, Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Liver Angiosarcoma

MalaCards integrated aliases for Liver Angiosarcoma:

Name: Liver Angiosarcoma 12 14
Angiosarcoma of Liver 12 69
Hemangiosarcoma of the Liver 12
Angiosarcoma of the Liver 50

Classifications:



External Ids:

Disease Ontology 12 DOID:268
ICD10 33 C22.3
NCIt 47 C4438
SNOMED-CT 64 109844006 187770005
UMLS 69 C0345907

Summaries for Liver Angiosarcoma

Disease Ontology : 12 An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located in the liver.

MalaCards based summary : Liver Angiosarcoma, also known as angiosarcoma of liver, is related to senior-boichis syndrome and bile duct mucinous adenocarcinoma. An important gene associated with Liver Angiosarcoma is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include liver and endothelial, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for Liver Angiosarcoma

Diseases related to Liver Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
id Related Disease Score Top Affiliating Genes
1 senior-boichis syndrome 10.9 KRT19 VIM
2 bile duct mucinous adenocarcinoma 10.8 KRAS KRT19
3 laryngeal neuroendocrine tumor 10.8 KRAS VIM
4 2q31.1 microdeletion syndrome 10.7 ENO2 VIM
5 uniparental disomy of chromosome 11 10.7 KRAS VIM
6 breast myoepithelial neoplasm 10.7 KRAS TP53
7 ampulla of vater squamous cell carcinoma 10.7 HBA1 VIM
8 coloboma of inferior eyelid 10.7 KRAS TP53
9 benallegue lacete syndrome 10.6 ENO2 VIM
10 malignant skin fibrous histiocytoma 10.6 HRAS KRAS
11 intellectual disability-polydactyly-uncombable hair syndrome 10.6 ENO2 VIM
12 striatonigral degeneration 10.6 CAMTA1 HBA1 YAP1
13 gastric signet ring cell adenocarcinoma 10.6 CD34 VIM
14 myoma 10.6 ENO2 VIM
15 limb ischemia 10.6 HRAS KRAS
16 inner ear cancer 10.6 CD34 VIM
17 rnase t2-deficient leukoencephalopathy 10.6 CDK4 TP53
18 dysgraphia 10.5 CD34 HBA1
19 severe pre-eclampsia 10.5 HRAS KRAS
20 ovarian lymphoma 10.5 CD34 HBA1
21 neurofibroma 10.5 CD34 HBA1
22 pineal region yolk sac tumor 10.5 ENO2 VIM
23 conventional angiosarcoma 10.5 CD34 HBA1
24 bullous keratopathy 10.5 CYP2E1 KRT19 TP53
25 pancreatic serous cystic neoplasm 10.5 KRAS KRT19 TP53
26 pleomorphic adenoma 10.5 CD34 HBA1
27 epidermal nevus, somatic 10.5 HRAS NRAS
28 periventricular nodular heterotopia 6 10.5 KRT19 TP53 VIM
29 apocrine adenocarcinoma 10.5 KRAS KRT19 TP53
30 vulvar dystrophy 10.5 CD34 HBA1
31 epidural neoplasm 10.5 CDK4 VWF
32 mitral valve stenosis 10.5 CAMTA1 HBA1 VWF
33 papillary meningioma of the cerebellum 10.5 CD34 HBA1
34 chronic polyneuropathy 10.5 HRAS NRAS
35 cervical adenoma malignum 10.5 CD34 HBA1
36 cervical endometrial stromal sarcoma 10.4 CD34 HBA1
37 multiple mucosal neuroma 10.4 CD34 TP53
38 skin papilloma 10.4 ENO2 VIM
39 microphthalmia/anophthalmia/coloboma spectrum 10.4 KRAS TP53
40 acinar cell cystadenocarcinoma 10.4 HRAS KRAS KRT19
41 myxoid leiomyosarcoma 10.4 ENO2 VIM
42 chikungunya 10.4 TP53 VIM VWF
43 schimmelpenning-feuerstein-mims syndrome, somatic mosaic 10.4 HRAS KRAS NRAS
44 hyperandrogenism 10.4 ENO2 HBA1 KRT19
45 cowper gland carcinoma 10.4 CD34 TP53
46 enamel hypoplasia cataract hydrocephaly 10.4 CDK4 TP53 VIM
47 salivary gland adenoid cystic carcinoma 10.4 CD34 HBA1
48 occupational dermatitis 10.4 HRAS KRAS NRAS
49 split hand split foot nystagmus 10.4 HRAS TP53
50 demyelinating polyneuropathy 10.4 HRAS KRT19 NRAS

Graphical network of the top 20 diseases related to Liver Angiosarcoma:



Diseases related to Liver Angiosarcoma

Symptoms & Phenotypes for Liver Angiosarcoma

MGI Mouse Phenotypes related to Liver Angiosarcoma:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.3 CAMTA1 CDK4 CYP2E1 ENO2 HRAS KRAS
2 cardiovascular system MP:0005385 10.29 NRAS TP53 VIM VWF WWTR1 YAP1
3 cellular MP:0005384 10.28 YAP1 CD34 CDK4 ENO2 KRAS KRT19
4 growth/size/body region MP:0005378 10.24 CAMTA1 CDK4 ENO2 HRAS KRAS KRT19
5 homeostasis/metabolism MP:0005376 10.22 CD34 CDK4 CYP2E1 HRAS KRAS NRAS
6 mortality/aging MP:0010768 10.18 CAMTA1 CDK4 CYP2E1 HRAS KRAS KRT19
7 immune system MP:0005387 10.16 CD34 CDK4 KRAS NRAS TFE3 TP53
8 digestive/alimentary MP:0005381 10.13 KRAS KRT19 NRAS TP53 VWF WWTR1
9 endocrine/exocrine gland MP:0005379 10.11 CDK4 HRAS KRAS KRT19 NRAS TP53
10 integument MP:0010771 10.09 CD34 CDK4 HRAS KRAS KRT19 NRAS
11 neoplasm MP:0002006 10.02 CAMTA1 CD34 CDK4 CYP2E1 HRAS KRAS
12 nervous system MP:0003631 9.96 VIM VWF YAP1 CAMTA1 CDK4 ENO2
13 liver/biliary system MP:0005370 9.95 CDK4 CYP2E1 KRAS NRAS TP53 WWTR1
14 normal MP:0002873 9.76 CAMTA1 CDK4 HRAS KRAS KRT19 NRAS
15 pigmentation MP:0001186 9.35 CDK4 KRAS NRAS TFE3 TP53
16 respiratory system MP:0005388 9.17 VIM WWTR1 YAP1 ENO2 HRAS KRAS

Drugs & Therapeutics for Liver Angiosarcoma

Drugs for Liver Angiosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Identification, Molecular Epidemiology Angiosarcoma of the Liver France Active, not recruiting NCT01786889
2 Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation Not yet recruiting NCT03025438

Search NIH Clinical Center for Liver Angiosarcoma

Genetic Tests for Liver Angiosarcoma

Anatomical Context for Liver Angiosarcoma

MalaCards organs/tissues related to Liver Angiosarcoma:

39
Liver, Endothelial

Publications for Liver Angiosarcoma

Articles related to Liver Angiosarcoma:

(show all 18)
id Title Authors Year
1
Sequential development of hepatocellular carcinoma and liver angiosarcoma in a vinyl chloride-exposed worker. ( 27544804 )
2016
2
Liver Angiosarcoma: Rare tumour associated with a poor prognosis, literature review and case report. ( 27718433 )
2016
3
Liver angiosarcoma, a rare liver malignancy, presented with intraabdominal bleeding due to rupture--a case report. ( 22280556 )
2012
4
Widening spectrum of liver angiosarcoma in children. ( 21832953 )
2011
5
Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride. ( 12211074 )
2002
6
Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer. ( 10964802 )
2000
7
Establishment and characterization of a spontaneously immortalized myofibroblast cell line derived from a human liver angiosarcoma. ( 10952247 )
2000
8
Diffuse liver angiosarcoma and cerebral cavernous angiomas in a young patient. ( 10692780 )
1999
9
Two new cases of liver angiosarcoma: history and perspectives of liver angiosarcoma among plastic industry workers. ( 9284534 )
1997
10
Vinylchloride monomer exposure by the plastic industry workers basic condition for liver angiosarcoma appearance. ( 9277092 )
1996
11
Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure. ( 1793483 )
1991
12
Massive bleeding after fine needle aspiration of liver angiosarcoma. ( 2298353 )
1990
13
Invasive character of malignant endothelial cells in vinyl-chloride-induced liver angiosarcoma. ( 2381457 )
1990
14
Liver angiosarcoma in a vinyl chloride polymerization plant worker. Report of the seventh Italian case. ( 3173221 )
1988
15
Iatrogenic disease. Lipoid pneumonia and liver angiosarcoma. ( 3714604 )
1986
16
Two cases of liver angiosarcoma among polyvinyl chloride (PVC) extruders of an Italian factory producing PVC bags and other containers. ( 6539068 )
1984
17
Persistence of DNA damage during development of liver angiosarcoma in rats fed dimethylnitrosamine. ( 570883 )
1979
18
Log normal distribution of the incubation period of liver angiosarcoma in vinyl chloride polymerization workers. ( 569691 )
1979

Variations for Liver Angiosarcoma

Expression for Liver Angiosarcoma

Search GEO for disease gene expression data for Liver Angiosarcoma.

Pathways for Liver Angiosarcoma

Pathways related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

(show all 49)
id Super pathways Score Top Affiliating Genes
1 12.67 CDK4 HRAS KRAS NRAS TP53 VWF
2 12.66 CDK4 HRAS KRAS NRAS TP53
3
Show member pathways
12.56 HRAS KRAS NRAS TP53 YAP1
4
Show member pathways
12.49 HRAS KRAS NRAS TP53
5 12.48 HRAS KRAS NRAS TP53 VIM
6
Show member pathways
12.47 HRAS KRAS NRAS TP53
7
Show member pathways
12.42 HRAS KRAS NRAS TP53
8
Show member pathways
12.4 CDK4 HRAS KRAS NRAS
9
Show member pathways
12.34 HRAS KRAS NRAS TP53
10
Show member pathways
12.32 CDK4 HRAS KRAS NRAS VIM
11
Show member pathways
12.3 HRAS KRAS NRAS TP53
12 12.3 CDK4 HRAS KRAS NRAS TP53
13 12.29 HRAS KRAS NRAS TP53
14
Show member pathways
12.28 HRAS KRAS NRAS VWF
15
Show member pathways
12.21 CDK4 HRAS KRAS NRAS TP53
16
Show member pathways
12.2 HRAS KRAS NRAS TP53
17
Show member pathways
12.17 HRAS KRAS NRAS TP53
18
Show member pathways
12.13 HRAS KRAS NRAS TP53
19
Show member pathways
12.13 HRAS KRAS NRAS TP53
20
Show member pathways
12.07 HRAS KRAS NRAS VWF
21 12.07 CDK4 HRAS KRAS NRAS TP53
22
Show member pathways
12.04 CDK4 HRAS KRAS NRAS
23 12.04 HRAS KRAS NRAS TP53
24
Show member pathways
12.03 HRAS KRAS NRAS TP53
25 11.96 HRAS KRAS NRAS TP53
26 11.93 HRAS KRAS NRAS TP53
27 11.92 HRAS KRAS NRAS TP53
28 11.91 HRAS KRAS NRAS
29
Show member pathways
11.87 HRAS KRAS NRAS YAP1
30
Show member pathways
11.84 HRAS KRAS NRAS
31
Show member pathways
11.79 HRAS KRAS NRAS
32 11.77 CDK4 HRAS KRAS NRAS
33
Show member pathways
11.67 HRAS KRAS NRAS
34 11.63 HRAS KRAS NRAS
35 11.6 CDK4 HRAS KRAS NRAS TP53
36 11.59 HRAS KRAS NRAS
37 11.52 HRAS KRAS NRAS
38 11.44 HRAS KRAS NRAS TP53
39 11.32 HRAS KRAS NRAS
40 11.24 HRAS KRAS NRAS
41 11.23 HRAS KRAS NRAS
42 11.22 CDK4 HRAS KRAS NRAS TP53
43
Show member pathways
11.19 HRAS KRAS NRAS
44
Show member pathways
11.12 HRAS KRAS NRAS
45 10.99 HRAS KRAS NRAS
46 10.95 HRAS KRAS NRAS
47 10.88 HRAS KRAS NRAS
48 10.83 HRAS KRAS NRAS TFE3 TP53
49 10.55 HRAS KRAS NRAS

GO Terms for Liver Angiosarcoma

Cellular components related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.4 CAMTA1 CDK4 ENO2 HBA1 HRAS KRAS

Biological processes related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.71 CD34 HRAS KRAS NRAS
2 positive regulation of gene expression GO:0010628 9.65 CD34 HRAS KRAS TP53 VIM
3 epidermal growth factor receptor signaling pathway GO:0007173 9.5 HRAS KRAS NRAS
4 response to isolation stress GO:0035900 9.43 HRAS KRAS
5 heterocycle metabolic process GO:0046483 9.37 CYP2E1 UGT1A1
6 ERBB2 signaling pathway GO:0038128 9.33 HRAS KRAS NRAS
7 cellular response to gamma radiation GO:0071480 9.13 HRAS TP53 YAP1
8 Ras protein signal transduction GO:0007265 8.92 HRAS KRAS NRAS TP53

Molecular functions related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex binding GO:0032403 8.92 CDK4 KRAS KRT19 NRAS

Sources for Liver Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....