HCC
MCID: LVR011
MIFTS: 91

Liver Cancer (HCC) malady

Genetic diseases, Rare diseases, Liver diseases, Cancer diseases, Gastrointestinal diseases categories
Download this MalaCard

Summaries for Liver Cancer

About this section


Fully expand this MalaCard
MedlinePlus:33 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. primary liver cancer starts in the liver. metastatic liver cancer starts somewhere else and spreads to your liver. risk factors for primary liver cancer include having hepatitis b or c heavy alcohol use having cirrhosis, or scarring of the liver having hemochromatosis, an iron storage disease obesity and diabetes symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. however, you may not have symptoms until the cancer is advanced. this makes it harder to treat. doctors use tests that examine the liver and the blood to diagnose liver cancer. treatment options include surgery, radiation, chemotherapy, or liver transplantation. nih: national cancer institute

MalaCards based summary: Liver Cancer, also known as hepatocellular carcinoma, is related to cholangiocarcinoma and medulloblastoma. An important gene associated with Liver Cancer is TP53 (tumor protein p53), and among its related pathways are Apoptosis Signaling Pathways and Apoptotic cleavage of cellular proteins. The drugs mechlorethamine and irinotecan and the compounds crcs and staurosporin have been mentioned in the context of this disorder. Affiliated tissues include the liver, liver and skin, and related mouse phenotypes are renal/urinary system and craniofacial.

Disease Ontology:8 A gastrointestinal system cancer that is located in the liver.

Wikipedia:65 Liver cancer or hepatic cancer (from the Greek h?par, meaning liver) is a cancer that originates in the... more...

Description from OMIM:46 114550

Aliases & Classifications for Liver Cancer

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 26ICD10 via Orphanet
See all sources

Liver Cancer, Aliases & Descriptions:

Name: Liver Cancer 8 42 33
Hepatocellular Carcinoma 46 10 44 62
Resectable Malignant Neoplasm of Liver 8 62
Primary Malignant Neoplasm of Liver 8 62
Malignant Hepato-Biliary Neoplasm 8 62
Malignant Neoplasm of Liver 8 62
Malignant Tumor of Liver 8 62
Hepatocellular Cancer 42 22
Neoplasm of Liver 8 62
Hepatic Neoplasm 8 62
Hepatic Cancer 8 44
Liver Neoplasm 8 10
Hepatoma 42 62
Hcc 42 62
Epithelial Hepatic and Intrahepatic Bile Duct Neoplasm 8
Malignant Neoplasm of Liver, Not Specified As Primary 8
Non-Resectable Primary Hepatic Malignant Neoplasm 8
Liver and Intrahepatic Biliary Tract Carcinoma 62
Resectable Malignant Neoplasm of the Liver 8
 
Malignant Neoplasm of Liver Unspecified 8
Primary Malignant Neoplasm of Liver Nos 8
Adult Primary Hepatocellular Carcinoma 62
Hepatocellular Carcinoma of the Mouse 62
Malignant Neoplasm of Liver, Primary 8
Hepatocellular Carcinoma, Adult 42
Adult Hepatocellular Carcinoma 48
Liver Cell Carcinoma Adult 42
Primary Tumor of the Liver 42
Cancer, Hepatocellular 62
Primary Liver Cancer 8
Neoplasm Metastasis 62
Liver Cancer Adult 42
Ca Liver - Primary 8
Hepatocarcinoma 42
Liver Carcinoma 62
Liver Neoplasms 62
Secondary 8


Classifications:



Related Diseases for Liver Cancer

About this section

Diseases in the Liver Cancer family:

Liver Carcinoma in Situ

Diseases related to Liver Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 2588)
idRelated DiseaseScoreTop Affiliating Genes
1cholangiocarcinoma30.8AFP, PIK3CA, MET, TP53
2medulloblastoma30.4CTNNB1, APC
3hepatocellular carcinoma, somatic30.4PIK3CA, CTNNB1, AXIN1, CASP8
4colorectal cancer30.4PDGFRL, CTNNB1
5gardner syndrome30.4APC, CTNNB1
6turcot syndrome30.3APC, CTNNB1
7adenoma30.2IGF2R, APC, CTNNB1, TP53, MET
8gallbladder cancer30.2TP53, APC
9lynch syndrome30.1APC, TP53
10hepatoblastoma30.1MET, APC, AFP, CTNNB1
11desmoid tumor30.0APC, CTNNB1
12acinar cell carcinoma30.0CTNNB1, AFP
13cervical cancer30.0TP53, PIK3CA, AXIN1, CASP8
14hepatocellular adenoma30.0APC, CTNNB1, AFP
15rhabdomyosarcoma29.9TP53, CASP8, MET
16juvenile polyposis syndrome29.9APC
17malignant mixed mullerian tumor29.9CTNNB1, TP53, AFP
18follicular thyroid carcinoma29.9EGF, PIK3CA
19familial adenomatous polyposis29.9AXIN1, CTNNB1, TP53, APC
20kidney cancer29.8PIK3CA, MET, CASP8, EGF
21osteosarcoma29.8CASP8, IGF2R, MET, TP53
22ataxia telangiectasia29.7CDKN3, PIK3CA, AFP, TP53
23fibromatosis29.7CTNNB1, APC
24colon adenocarcinoma29.7EGF, CTNNB1, CASP8
25bladder carcinoma29.7CASP8, TP53, PIK3CA, EGF
26pancreatic cancer29.7MET, EGF, IGF2R
27choriocarcinoma29.6AFP, CASP8, EGF
28lung cancer29.6EGF, CASP8, MET, TP53, IGF2R, PIK3CA
29peutz-jeghers syndrome29.6CTNNB1, CDKN3, APC
30breast cancer29.5PIK3CA, IGF2R, APC, EGF, CTNNB1
31leukemia29.5CDKN3, PIK3CA, CASP8, TP53, IGF2R, EGF
32adenocarcinoma29.5AFP, APC, TP53, MET, CASP8, EGF
33papillary thyroid carcinoma29.4APC, CTNNB1, MET
34astrocytoma29.4PIK3CA, CDKN3, CASP8, MET, EGF, TP53
35ovarian cancer29.4PIK3CA, TP53, MET, EGF, CASP8, CTNNB1
36gastric adenocarcinoma29.4PIK3CA, MET, CASP8, CTNNB1, APC, AFP
37melanoma29.3CTNNB1, CASP8, MET, TP53, PIK3CA
38endometrial carcinoma29.2TP53, PIK3CA, EGF, CDKN3, CTNNB1
39non-small cell lung carcinoma29.1MET, TP53, EGF, CASP8
40lung adenocarcinoma29.1PIK3CA, MET, TP53, CASP8, EGF, CTNNB1
41prostate cancer29.0CDKN3, EGF, CTNNB1, MET, CASP8
42retinoblastoma29.0CDKN3, EGF, APC, CASP8, PIK3CA, TP53
43glioblastoma multiforme28.9TP53, MET, PIK3CA, CDKN3, CASP8, EGF
44glioblastoma28.9CASP8, PIK3CA, TP53, MET, CDKN3, EGF
45stomach cancer28.7PIK3CA, AFP, APC, TP53, MET, CASP8
46tongue squamous cell carcinoma28.7AXIN1, CTNNB1, MET, APC, IGF2R, PIK3CA
47malignant glioma28.5MET, TP53, IGF2R, EGF, CASP8, CDKN3
48syphilis10.9
49secondary syphilis10.9
50hyperparathyroidism10.9

Graphical network of the top 20 diseases related to Liver Cancer:



Diseases related to liver cancer

Symptoms for Liver Cancer

About this section


Clinical features from OMIM:

114550

Drugs & Therapeutics for Liver Cancer

About this section

Genetic Tests for Liver Cancer

About this section

Genetic tests related to Liver Cancer:

id Genetic test Affiliating Genes
1 Hepatocellular Carcinoma22

Anatomical Context for Liver Cancer

About this section

MalaCards organs/tissues related to Liver Cancer:

32
Liver, Skin, Testes, Breast, T cells, Prostate, Colon, Endothelial, Lung, Pancreas, Lymph node, Spleen, Kidney, Testis, Cervix

FMA organs/tissues related to Liver Cancer:

14
The liver

Animal Models for Liver Cancer or affiliated genes

About this section

MGI Mouse Phenotypes related to Liver Cancer:

36 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.6IGF2R, APC, TP53, MET, CASP8, CTNNB1
2MP:000538210.6IGF2R, APC, TP53, MET, DLC1, CTNNB1
3MP:000537010.6IGF2R, APC, TP53, MET, MAT1A, CASP8
4MP:000537110.5IGF2R, APC, TP53, MET, CTNNB1, AXIN1
5MP:000537910.5PIK3CA, AFP, APC, TP53, MET, CASP8
6MP:000538010.5AXIN1, PIK3CA, IGF2R, APC, TP53, MET
7MP:000538510.5PIK3CA, IGF2R, APC, TP53, MET, CASP8
8MP:000200610.5PIK3CA, AFP, APC, TP53, MET, CTNNB1
9MP:000287310.5IGF2R, APC, TP53, MET, DLC1, EGF
10MP:000538910.5PIK3CA, IGF2R, AFP, APC, TP53, EGF
11MP:000537810.4PIK3CA, IGF2R, APC, TP53, MET, CASP8
12MP:000538810.4IGF2R, TP53, MET, CASP8, CTNNB1, AXIN1
13MP:000538410.4PIK3CA, IGF2R, APC, TP53, MET, CASP8
14MP:000537610.4PIK3CA, IGF2R, AFP, APC, TP53, MET
15MP:000363110.4PIK3CA, IGF2R, APC, TP53, MET, CASP8
16MP:000538610.3PIK3CA, IGF2R, AFP, APC, TP53, MET
17MP:000538110.3APC, TP53, MET, EGF, CTNNB1, AXIN1
18MP:001076810.3PIK3CA, IGF2R, AFP, APC, TP53, MET
19MP:001077110.3CTNNB1, EGF, CASP8, TP53, APC, PIK3CA
20MP:000539110.3PIK3CA, APC, TP53, MET, EGF, CTNNB1
21MP:000538710.1CASP8, MAT1A, MET, TP53, APC, PIK3CA
22MP:000536910.0CTNNB1, CASP8, MET, TP53, APC, PIK3CA

Publications for Liver Cancer

About this section

Articles related to Liver Cancer:

(show top 50)    (show all 435)
idTitleAuthorsYear
1
TRIB2 inhibits Wnt/I^-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, I^-TrCP, COP1 and Smurf1, in liver cancer cells. (25311538)
2014
2
TGF-I^-induced long non-coding RNA promotes liver cancer metastasis via RNA-RNA cross-talk. (25380484)
2014
3
Association of serum I+-tocopherol, I^-carotene, and retinol with liver cancer incidence and chronic liver disease mortality. (25314058)
2014
4
MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer. (24211253)
2013
5
Clinical usefulness of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography for patients with primary liver cancer with special reference to rare histological types, hepatocellular carcinoma with sarcomatous change and combined hepatocellular and cholangiocarcinoma. (23145869)
2013
6
NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway. (23474366)
2013
7
Association between serum 25(OH) vitamin D, incident liver cancer and chronic liver disease mortality in the Linxian Nutrition Intervention Trials: a nested case-control study. (24008664)
2013
8
A comparison of trends in mortality from primary liver cancer and intrahepatic cholangiocarcinoma in Europe. (23378539)
2013
9
CD133 silencing inhibits stemness properties and enhances chemoradiosensitivity in CD133-positive liver cancer stem cells. (23233126)
2013
10
Nuclear accumulation of seven in absentia homologue-2 supports motility and proliferation of liver cancer cells. (22323152)
2012
11
Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis. (22370893)
2012
12
Folate metabolism-related gene polymorphisms and susceptibility to primary liver cancer in North China. (21956592)
2012
13
SP1 plays a pivotal role for basal activity of TIGAR promoter in liver cancer cell lines. (21761199)
2012
14
SP1 suppresses phorbol 12-myristate 13-acetate induced up-regulation of human regucalcin expression in liver cancer cells. (21526343)
2011
15
Expression of mortalin detected in human liver cancer by tissue microarrays. (21714113)
2011
16
HURP expression-assisted risk scores identify prognosis distinguishable subgroups in early stage liver cancer. (22022601)
2011
17
Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathway. (20629949)
2010
18
Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells. (20562100)
2010
19
Meta-analysis of the efficacy of transcatheter arterial chemoembolization combined with percutaneous ethanol injection in treating unresectable primary liver cancer]. (19595117)
2009
20
Photodynamic effect of two kinds of phycobiliproteins on human liver cancer cell line SMMC-7721 in vitro]. (19938487)
2009
21
16alpha-hydroxyestrone inhibits estrogen sulfotransferase activity in human liver cancer cells. (19250210)
2009
22
The activity of class I, II, III, and IV alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in liver cancer. (18224440)
2008
23
Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid. (17593366)
2008
24
Deleted in liver cancer 1 controls cell migration through a Dia1-dependent signaling pathway. (18974116)
2008
25
Insulin/PI3K signalling pathway regulates the expression of survivin in liver cancer HepG2 cells]. (19173802)
2008
26
S-Adenosylmethionine in cell growth, apoptosis and liver cancer. (18336669)
2008
27
Absence of E17K mutation in the pleckstrin homology domain of AKT1 in gastrointestinal and liver cancers in the Korean population. (18754328)
2008
28
N-linked glycosylation of the liver cancer biomarker GP73. (18004786)
2008
29
Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kappaB pathway. (17316946)
2007
30
Growth inhibitory effects of IFN-beta on human liver cancer cells in vitro and in vivo. (17572015)
2007
31
siRNA-mediated type 1 insulin-like growth factor receptor silencing induces chemosensitization of a human liver cancer cell line with mutant P53. (17097318)
2007
32
Expression of twist gene in primary liver cancer. (18231738)
2007
33
Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression. (16951145)
2006
34
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. (16054984)
2005
35
Primary liver cancer with bidirectional differentiation into hepatocytes and biliary epithelium. (16365824)
2005
36
Differential effects of interferon alpha-2b and beta on the signaling pathways in human liver cancer cells. (16082589)
2005
37
Integrative analysis of multiple gene expression profiles applied to liver cancer study. (15135059)
2004
38
Thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in hepatocellular carcinoma and metastatic liver cancer. (15254700)
2004
39
Capecitabine inhibits postoperative recurrence and metastasis after liver cancer resection in nude mice with relation to the expression of platelet-derived endothelial cell growth factor. (14676129)
2003
40
Human fetuin/alpha2HS-glycoprotein level as a novel indicator of liver cell function and short-term mortality in patients with liver cirrhosis and liver cancer. (11943951)
2002
41
Expression of liver cancer associated gene HCCA3. (11854909)
2001
42
Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis. (11549587)
2001
43
Subclinical course of cholesteryl ester storage disease in an adult with hypercholesterolemia, accelerated atherosclerosis, and liver cancer. (10735626)
2000
44
Invasion and metastasis of liver cancer: expression of intercellular adhesion molecule 1. (10037274)
1999
45
Expression of sialyl-Tn, Tn and T antigens in primary liver cancer. (10365852)
1999
46
Primary liver cancer in two sisters in Holland with intermittent acute porphyria. (9254746)
1997
47
Evaluation of the therapeutic effect of TAE on primary liver cancer. (7511068)
1994
48
Effects of cisplatin, carboplatin, etoposide and human hepatocyte growth factor on the colony formation of four human liver cancer cell lines]. (8215470)
1993
49
Pharmacokinetic study of tegafur in the hepatic tissue obtained from the patients with liver cancer]. (1580640)
1992
50
Early diagnosis of alpha fetoprotein nonproducing primary liver cancer]. (1698135)
1990

Variations for Liver Cancer

About this section

UniProtKB/Swiss-Prot genetic disease variations for Liver Cancer:

64 (show all 21)
id Symbol AA change Variation ID SNP ID
1AXIN1p.Leu106ArgVAR_015589
2AXIN1p.Pro345LeuVAR_015590
3AXIN1p.Gly425SerVAR_015591rs116350678
4AXIN1p.Gly650SerVAR_015592rs117208012
5CDKN3p.Trp31ArgVAR_013842
6CDKN3p.Phe78LeuVAR_013843
7CDKN3p.Cys79TyrVAR_013844
8CDKN3p.Asn91LysVAR_013845
9CDKN3p.Asp94ValVAR_013846
10CDKN3p.Leu95PheVAR_013847
11CDKN3p.Ile108ValVAR_013848rs144479038
12CDKN3p.Asn187SerVAR_013849
13CDKN3p.Lys195IleVAR_013850
14METp.Thr1173IleVAR_032490
15METp.Lys1244ArgVAR_032492
16METp.Met1250IleVAR_032493
17MTUS1p.Gln75LysVAR_035173rs61733703
18MTUS1p.Ala563SerVAR_035178
19MTUS1p.Asn873HisVAR_035180rs187103704
20MTUS1p.Gln1201ArgVAR_035184
21PIK3CAp.Glu545AlaVAR_026176

Clinvar genetic disease variations for Liver Cancer:

6 (show all 13)
id Gene Name Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.747G> T (p.Arg249Ser)single nucleotide variantPathogenicrs28934571GRCh37Chr 17, 7577534: 7577534
2TP53NM_000546.5(TP53): c.469G> T (p.Val157Phe)single nucleotide variantPathogenicrs121912654GRCh37Chr 17, 7578461: 7578461
3PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
4PIK3CANM_006218.2(PIK3CA): c.3203dupA (p.Asn1068Lysfs)duplicationPathogenicGRCh37Chr 3, 178952148: 178952148
5PIK3CANM_006218.2(PIK3CA): c.1634A> C (p.Glu545Ala)single nucleotide variantPathogenicrs121913274GRCh37Chr 3, 178936092: 178936092
6IGF2RNM_000876.2(IGF2R): c.4346G> T (p.Gly1449Val)single nucleotide variantPathogenicrs121434587GRCh37Chr 6, 160490993: 160490993
7IGF2RNM_000876.2(IGF2R): c.4391G> A (p.Gly1464Glu)single nucleotide variantPathogenicrs121434588GRCh37Chr 6, 160491038: 160491038
8CTNNB1NM_001904.3(CTNNB1): c.134C> T (p.Ser45Phe)single nucleotide variantPathogenicrs121913409GRCh37Chr 3, 41266137: 41266137
9CTNNB1NM_001904.3(CTNNB1): c.133T> C (p.Ser45Pro)single nucleotide variantLikely pathogenicrs121913407GRCh37Chr 3, 41266136: 41266136
10PDGFRLPDGRL, 2-BP DELdeletionPathogenic
11AXIN1NM_003502.3(AXIN1): c.1085_1116del32 (p.Val362Alafs)deletionPathogenicGRCh38Chr 16, 309973: 310004
12CASP8NM_001228.4(CASP8): c.1279_1280delGT (p.Val427Phefs)deletionPathogenicGRCh37Chr 2, 202149964: 202149965
13APCNM_000038.5(APC): c.1695delA (p.Val566Leufs)deletionPathogenicrs397514032GRCh37Chr 5, 112164621: 112164621

Expression for genes affiliated with Liver Cancer

About this section
Expression patterns in normal tissues for genes affiliated with Liver Cancer

Search GEO for disease gene expression data for Liver Cancer.

Pathways for genes affiliated with Liver Cancer

About this section

Pathways related to Liver Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
10.4TP53, CASP8, AXIN1
2
Show member pathways
10.4APC, CASP8, CTNNB1
3
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
10.4TP53, CASP8, PIK3CA
4
Show member pathways
10.4CASP8, TP53, PIK3CA
510.4APC, CTNNB1, AXIN1
610.4CTNNB1, AXIN1, APC
710.4CTNNB1, APC, AXIN1
8
Show member pathways
RAC1 signaling pathway37
10.4PIK3CA, APC, CTNNB1
910.4PIK3CA, AXIN1, CTNNB1
10
Show member pathways
10.4PIK3CA, IGF2R, TP53
1110.4MET, TP53, IGF2R
1210.4CTNNB1, EGF, TP53
13
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
10.4MET, TP53, PIK3CA
1410.4CTNNB1, PIK3CA, MET
15
Show member pathways
10.4PIK3CA, TP53, EGF
1610.4CTNNB1, PIK3CA, EGF
17
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
10.4CTNNB1, PIK3CA, EGF
1810.4CTNNB1, EGF, MET
1910.4PIK3CA, EGF, MET
2010.4MET, EGF, PIK3CA
21
Show member pathways
10.4APC, AXIN1, TP53, CTNNB1
2210.4CTNNB1, APC, TP53, AXIN1
23
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
10.4CTNNB1, TP53, APC, AXIN1
24
Show member pathways
Wnt Signaling Pathway NetPath37
10.4CTNNB1, TP53, APC, AXIN1
2510.4CTNNB1, AXIN1, APC, CASP8
26
Show member pathways
10.4CASP8, MET, CTNNB1, TP53
2710.4PIK3CA, APC, TP53, CTNNB1
2810.3PIK3CA, CTNNB1, MET, TP53
2910.3APC, CTNNB1, EGF, TP53
3010.3TP53, APC, PIK3CA, MET
3110.3CTNNB1, MET, APC, PIK3CA
3210.3APC, AFP, AXIN1, CTNNB1
3310.3APC, AXIN1, CTNNB1, AFP
3410.3MET, AFP, TP53, APC
3510.3PIK3CA, TP53, MET, EGF
36
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
10.3MET, EGF, PIK3CA, TP53
37
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
10.3APC, CASP8, AXIN1, TP53, CTNNB1
38
Show member pathways
10.3CTNNB1, EGF, MET, PIK3CA
39
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
10.3CTNNB1, PIK3CA, MET, EGF
4010.3AXIN1, CTNNB1, EGF, APC, TP53
41
Show member pathways
10.3IGF2R, EGF, MET, CASP8, TP53
42
Show member pathways
10.3MET, CTNNB1, EGF, CASP8, IGF2R
43
Show member pathways
Signaling Pathways in Glioblastoma37
10.3PIK3CA, TP53, MET, EGF, CTNNB1
44
Show member pathways
10.3PIK3CA, CTNNB1, IGF2R, TP53, MET, CASP8
4510.3TP53, CTNNB1, PIK3CA, APC, EGF, CASP8
46
Show member pathways
Signal transduction PTEN pathway60
10.3AXIN1, PIK3CA, CTNNB1, EGF, TP53, APC
47
Show member pathways
10.3AXIN1, CTNNB1, CASP8, MET, EGF, APC
48
Show member pathways
10.2DLC1, EGF, AXIN1, CTNNB1, PIK3CA, APC
49
Show member pathways
10.2TP53, APC, EGF, MET, CASP8, IGF2R
5010.2APC, TP53, MET, CASP8, EGF, CTNNB1

Compounds for genes affiliated with Liver Cancer

About this section

Compounds related to Liver Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1crcs4410.8MET, TP53, CTNNB1, PIK3CA, APC
2staurosporin4410.7CDKN3, PIK3CA, EGF, CASP8
3bicalutamide44 61 1112.7CTNNB1, EGF, CDKN3, CASP8
4sulindac44 1111.7TP53, CASP8, CTNNB1, APC
5ag 14784410.7CTNNB1, PIK3CA, EGF, CASP8, MET
6nocodazole44 1111.7APC, TP53, EGF, CTNNB1, CDKN3
7gefitinib44 50 1112.7MET, EGF, CDKN3, CTNNB1, PIK3CA
8adriamycin4410.7TP53, MET, AFP, CASP8, CTNNB1
9egcg4410.7CASP8, TP53, PIK3CA, EGF, CTNNB1
105fluorouracil4410.7CTNNB1, EGF, CASP8, TP53, PIK3CA, AFP
11ly2940024410.7PIK3CA, TP53, MET, CASP8, CDKN3, EGF
12trastuzumab44 50 1112.7CTNNB1, CDKN3, PIK3CA, EGF
13butyrate4410.7CTNNB1, TP53, CASP8, CDKN3, EGF, AFP
14doxorubicin44 50 1112.7EGF, PIK3CA, CTNNB1, CASP8, MET, TP53
15arsenite44 2411.7PIK3CA, CDKN3, CASP8, TP53, CTNNB1
16wortmannin4410.6PIK3CA, IGF2R, CTNNB1, CASP8, CDKN3, MET
17glycogen44 2411.6PIK3CA, IGF2R, AFP, MET, CDKN3, CTNNB1
18paclitaxel44 50 1112.6AFP, CASP8, EGF, PIK3CA, CTNNB1, TP53
19pdtc4410.6MET, CASP8, TP53, PIK3CA
20actinomycin d4410.6PIK3CA, EGF, CDKN3, CASP8, MET, TP53
21cisplatin44 50 61 1113.6MET, EGF, CASP8, CTNNB1, TP53, CDKN3
22cycloheximide4410.6TP53, MET, CDKN3, EGF, APC, CTNNB1
23rapamycin4410.6CDKN3, EGF, MET, APC, PIK3CA, CTNNB1
24progesterone44 28 61 24 1114.6AFP, APC, TP53, MET, EGF, CTNNB1
25bleomycin44 1111.6AFP, TP53, CDKN3, CTNNB1
26phosphoinositide4410.6MET, CTNNB1, APC, EGF, PIK3CA, CDKN3
27adpribose4410.6TP53, CTNNB1, CASP8, PIK3CA
28threonine4410.6PIK3CA, IGF2R, AFP, APC, MET, CASP8
29agar4410.6PIK3CA, AFP, MET, CTNNB1, EGF
30vegf4410.6CTNNB1, EGF, PIK3CA, IGF2R, AFP, TP53
31h2o24410.6CTNNB1, AFP, EGF, CASP8, CDKN3, TP53
32retinoic acid44 2411.6AFP, PIK3CA, CTNNB1, EGF, CDKN3, CASP8
33estrogen4410.6IGF2R, AFP, TP53, MET, CDKN3, CTNNB1
34etoposide44 50 61 1113.6PIK3CA, CDKN3, TP53, CASP8, AFP
35thymidine44 2411.6PIK3CA, AFP, TP53, MET, EGF, CTNNB1
36geldanamycin44 50 61 1113.6EGF, CTNNB1, TP53, MET
37testosterone44 61 24 1113.6PIK3CA, AFP, APC, MET, CTNNB1, EGF
38sulindac sulfide4410.6TP53, EGF, CASP8
39phosphatidylinositol4410.6MET, APC, CDKN3, CTNNB1, PIK3CA, EGF
40phosphotyrosine4410.5PIK3CA, MET, EGF, CTNNB1, CDKN3
41serine4410.5AFP, CASP8, MET, PIK3CA, CDKN3, EGF
42resveratrol44 61 24 1113.5CASP8, TP53, PIK3CA, CTNNB1
43tyrosine4410.5MET, APC, AFP, PIK3CA, IGF2R, CDKN3
441-hydroxyanthraquinone4410.5APC, CTNNB1
45methylazoxymethanol acetate4410.4CTNNB1, APC
46cysteine4410.4IGF2R, CTNNB1, CDKN3, MET, CASP8, EGF
47pd 98,0594410.4CTNNB1, PIK3CA, CASP8, EGF, MET
48tgf beta14410.3CASP8, AFP, CTNNB1, EGF
49cytochalasin d44 6111.2EGF, CTNNB1, CASP8, CDKN3
50mg 13244 6111.0CTNNB1, EGF, CASP8, TP53

GO Terms for genes affiliated with Liver Cancer

About this section

Cellular components related to Liver Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.5AXIN1, CTNNB1, APC
2cell peripheryGO:07194410.4AXIN1, CTNNB1
3lateral plasma membraneGO:01632810.4APC, CTNNB1, AXIN1
4cytoplasmGO:00573710.1AXIN1, PPIAL4C, AFP, APC, TP53, CHD1L
5cytosolGO:00582910.1PIK3CA, APC, TP53, MAT1A, CASP8, AXIN1
6lamellipodiumGO:03002710.1PIK3CA, APC, CTNNB1

Biological processes related to Liver Cancer according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1T cell differentiation in thymusGO:03307710.7CTNNB1, TP53, APC
2regulation of protein localization to cell surfaceGO:200000810.7EGF, CTNNB1
3cellular component disassembly involved in execution phase of apoptosisGO:00692110.7CTNNB1, CASP8, APC
4regulation of calcium ion importGO:09027910.7EGF, CTNNB1
5canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:04433610.7APC, CTNNB1
6canonical Wnt signaling pathwayGO:06007010.6APC, CTNNB1, AXIN1
7negative regulation of cell proliferationGO:00828510.6APC, TP53, DLC1, CDKN3, CTNNB1
8apoptotic processGO:00691510.6AXIN1, APC, TP53, CASP8, DLC1, CTNNB1
9liver developmentGO:00188910.6CTNNB1, MET, IGF2R
10dorsal/ventral axis specificationGO:00995010.6AXIN1, CTNNB1
11positive regulation of apoptotic processGO:04306510.5IGF2R, APC, TP53, CTNNB1
12positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.5AXIN1, EGF
13positive regulation of peptidyl-threonine phosphorylationGO:01080010.5EGF, AXIN1
14cytoplasmic microtubule organizationGO:03112210.4AXIN1, APC
15cellular response to DNA damage stimulusGO:00697410.4CHD1L, TP53, APC
16cell cycle arrestGO:00705010.3APC, TP53, CDKN3
17proximal/distal pattern formationGO:00995410.1CTNNB1, APC

Molecular functions related to Liver Cancer according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:01990310.5TP53, MET, CTNNB1
2enzyme bindingGO:01989910.4IGF2R, TP53, CTNNB1, AXIN1
3ubiquitin protein ligase bindingGO:03162510.4AXIN1, CASP8, TP53
4protein kinase bindingGO:01990110.4AXIN1, CTNNB1, TP53, APC
5I-SMAD bindingGO:07041110.3CTNNB1, AXIN1
6protein bindingGO:00551510.2AXIN1, PIK3CA, IGF2R, APC, TP53, CHD1L
7R-SMAD bindingGO:07041210.1AXIN1, CTNNB1

Products for genes affiliated with Liver Cancer

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Liver Cancer

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet