MCID: LVR012
MIFTS: 75

Liver Cirrhosis malady

Liver diseases category

Summaries for Liver Cirrhosis

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Cirrhosis is scarring of the liver. scar tissue forms because of injury or long-term disease. scar tissue cannot do what healthy liver tissue does - make protein, help fight infections, clean the blood, help digest food and store energy. cirrhosis can lead to easy bruising or bleeding, or nosebleeds swelling of the abdomen or legs extra sensitivity to medicines high blood pressure in the vein entering the liver enlarged veins called varices in the esophagus and stomach. varices can bleed suddenly. kidney failure jaundice severe itching gallstones a small number of people with cirrhosis get liver cancer. your doctor will diagnose cirrhosis with blood tests, imaging tests, or a biopsy. cirrhosis has many causes. in the united states, the most common causes are chronic alcoholism and hepatitis. nothing will make the scar tissue disappear, but treating the cause can keep it from getting worse. if too much scar tissue forms, you may need to consider a liver transplant. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Liver Cirrhosis, also known as cirrhosis, is related to alcoholic liver cirrhosis and hepatitis. An important gene associated with Liver Cirrhosis is ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide), and among its related pathways are Metabolism and Biological oxidations. The drugs bumetanide and ethacrynate sodium and the compounds ethanol and aspartate have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related mouse phenotypes are homeostasis/metabolism and liver/biliary system.

Wikipedia:63 Cirrhosis /sɪˈroʊsɪs/ is a result of advanced liver disease. It is characterized by replacement of... more...

Aliases & Classifications for Liver Cirrhosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 33MedlinePlus, 56SNOMED-CT, 39NCIt, 34MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Aliases & Descriptions:

liver cirrhosis 8 10 44 30 60
cirrhosis 8 44 33 60
cirrhosis of liver nos 8
cirrhosis of liver 8


External Ids:

Disease Ontology8 DOID:5082
NCIt39 C2951
MeSH34 D008103

Related Diseases for Liver Cirrhosis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Liver Cirrhosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 524)
idRelated DiseaseScoreTop Affiliating Genes
1alcoholic liver cirrhosis31.7HGF, GPT
2hepatitis31.6IFNA1, GPT
3hepatocellular carcinoma31.5AHSG, ADH1B, ALB, CYP2E1, CYP2A6, NAT2
4hepatitis c31.2IFNA1, LSL, CYP2E1, GPT, F2, ASGR2
5hepatitis b31.2IFNA1, GPT, F2, ASGR2, ALB
6hypertension31.2F2, ALB
7hepatitis a31.2F2
8portal hypertension31.1GPT, F2, ALB
9alcoholic hepatitis31.0GPT, F2, ALB
10peritonitis30.9ALB, F2
11portal vein thrombosis30.9F2
12hepatic encephalopathy30.9GPT, F2, ALB
13hypersplenism30.8F2
14pancreatitis30.8CYP2E1, ALDH2, ALB, ADH1C, ADH1B
15viral hepatitis30.7IFNA1, AKR1A1, CYP2A6, GPT, F2, ADH1B
16alcoholic pancreatitis30.7AKR1A1, CYP2E1, ALDH2, ADH1C, ADH1B
17diabetes mellitus30.6LSL, IGFBP3, AHSG, CYP2E1, NAT2, GPT
18disseminated intravascular coagulation30.5TAT, F2
19peptic ulcer30.5AKR1A1
20primary biliary cirrhosis30.4ALB, ASGR2, F2, GPT
21thrombocytopenia30.4ALB, F2, GPT, IFNA1
22tuberculosis30.4LSL, AKR1A1, CYP2E1, CYP2A6, NAT2, TAT
23protein-energy malnutrition30.4ALB, TTR, LSL
24fatty liver disease30.3LSL, AHSG, CYP2E1, CYP2A6, GPT, PLIN2
25acute liver failure30.3HGF, GPT, F2, ALB
26autoimmune hepatitis30.3IFNA1, GPT, F2, ASGR2
27thyroiditis30.3IFNA1
28hypogonadism30.3IGFBP3, LSL
29rheumatoid arthritis30.2NAT2
30alcohol abuse30.1AKR1A1, CYP2E1, GPT, ALDH2, ADH1C
31acute pancreatitis30.1ADH1B, ADH1C, ALDH2, GPT
32obstructive jaundice30.1AKR1A1, GPT, TTR
33hypoglycemia30.1LSL, GHRH, IGFBP3
34alcohol dependence30.1ADH1B, ALDH2
35cholangiocarcinoma30.1NAT2, HGF
36cystic fibrosis30.1ALB, NAT2
37hyperparathyroidism30.1ALB
38siderosis30.1GPT
39psoriasis30.1NAT2
40cryoglobulinemia30.1IFNA1
41hepatitis d30.1GPT, IFNA1
42lupus erythematosus30.1NAT2, F2
43systemic lupus erythematosus30.1IFNA1, AHSG, NAT2, F2
44adenoma30.0GHRH, IGFBP3, CYP2A6, NAT2, ADH1C
45obesity29.9LSL, GHRH, IGFBP3, AHSG, CYP2E1, CYP2A6
46lung cancer29.9HGF, LSL, AKR1A1, IGFBP3, CYP2E1, CYP2A6
47adenocarcinoma29.9CYP2E1, CYP2A6, NAT2, TAT, ALDH2, ADH1C
48colon cancer29.9HGF, LSL, IGFBP3, CYP2A6, NAT2, TAT
49diarrhea29.9ALB, TTR
50atherosclerosis29.9LSL, AHSG, PLIN2, ALB

Graphical network of the top 20 diseases related to Liver Cirrhosis:



Diseases related to liver cirrhosis

Clinical Features for Liver Cirrhosis

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Drugs & Therapeutics for Liver Cirrhosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Liver Cirrhosis

Drug clinical trials:

Search ClinicalTrials for Liver Cirrhosis

Search NIH Clinical Center for Liver Cirrhosis

Search CenterWatch for Liver Cirrhosis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Liver Cirrhosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Liver Cirrhosis:
Autologous bone marrow-derived mesenchymal stem cells for liver cirhosis
Autologous bone marrow-derived stem cells for treatment of liver cirrhosis
Autologous hematopoietic stem cells for treatment of end-stage chronic liver disease
Bone marrow-derived endothelial progenitor cells for advanced liver cirrhosis
Bone marrow-derived mesenchymal stem cells for treatment of cirrhosis-related refractory ascites
Bone marrow-derived mesenchymal stem cells for treatment of liver cirrhosis
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Mesenchymal stem cells for liver cirrhosis
NU215-01, human umbilical cord mesenchymal stem cells for treatment of liver cirrhosis
Peripheral blood-derived CD34+ or mononuclear cells for liver cirrhosis
StempeucelLC
Umbilical cord-derived mesenchymal stem cells for treatment of liver cirrhosis
Embryonic/Adult Cultured Cells Related to Liver Cirrhosis:
Bone marrow-derived mesenchymal stem cells (family), PMIDs: 21771778, 22121493
Bone marrow-derived mesenchymal stem cells (family), PMID: 22121493
Peripheral blood-derived hematopoietic stem cells, PMID: 20587151
Bone marrow-derived endothelial progenitor cells (family)
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells (family)
Hepatocytes
Bone marrow-derived mesenchymal stem cells (family)
Umbilical cord-derived mesenchymal stem cells
Peripheral blood-derived mesenchymal stem cells (family)
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444
Umbilical cord-derived mesenchymal stem cells (family)

Genetic Tests for Liver Cirrhosis

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Anatomical Context for Liver Cirrhosis

About this section
Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Liver Cirrhosis:

32
Liver, Bone, Testes, Kidney, Bone marrow, Endothelial, Heart, T cells, Spleen, Monocytes, B cells, Small intestine, Thyroid, Prostate, Colon, Fetal liver, Pituitary, Brain, Lung, Lymph node, Pancreas, Skin

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Liver Cirrhosis:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
3 LiverSinusoidsHepatic Stellate Cells Affected by disease
4 LiverLiver LobuleHepatocytes Affected by disease
5 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
6 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Liver Cirrhosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Liver Cirrhosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.5ADH1C, AKR1A1, GHRH, IGFBP3, AHSG, CYP2E1
2MP:000537011.1GHRH, IGFBP3, CYP2E1, PLIN2, ALB, HGF

Publications for Liver Cirrhosis

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Sources:
50PubMed
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Articles related to Liver Cirrhosis:

(show top 50)    (show all 1682)
idTitleAuthorsYear
1
Predictive factors that influence the survival rates in liver cirrhosis patients with spontaneous bacterial peritonitis. (23837137)
2013
2
Next-generation sequence analysis of genes associated with obesity and nonalcoholic fatty liver disease-related cirrhosis in extreme obesity. (24081230)
2013
3
Interleukin 28B polymorphism predicts interferon plus ribavirin treatment outcome in patients with hepatitis C virus-related liver cirrhosis: A multicenter retrospective study in Japan. (24400682)
2013
4
Nonmalignant partial portal vein thrombosis in liver cirrhosis: to treat or not to treat? (23431230)
2013
5
Influence of Genetic Polymorphisms of Tumor Necrosis Factor Alpha and Interleukin 10 Genes on the Risk of Liver Cirrhosis in HIV-HCV Coinfected Patients. (23840511)
2013
6
An alternative treatment for muscle cramps in patients with liver cirrhosis. (23402616)
2013
7
Functional variants of eNOS and iNOS genes have no relationship to the portal hypertension in patients with liver cirrhosis. (23452051)
2013
8
Prognosis and determinants of pregnancy outcome among patients with post-hepatitis liver cirrhosis. (23518137)
2013
9
MR relaxometry of the liver: significant elevation of T1 relaxation time in patients with liver cirrhosis. (22302503)
2012
10
Detection of hepatopulmonary syndrome in patients with liver cirrhosis using 3D contrast echocardiography. (22560819)
2012
11
Brain surgery in patients with liver cirrhosis. (22631693)
2012
12
Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis. (22882828)
2012
13
The pharmacokinetics and pharmacodynamics of tolvaptan in patients with liver cirrhosis with insufficient response to conventional diuretics: a multicentre, double-blind, parallel-group, phase III study. (23321196)
2012
14
Mesenteric arteries responsiveness to acute variations of wall shear stress is impaired in rats with liver cirrhosis. (22774919)
2012
15
Severe inflammation in the background liver cirrhosis correlates with the development of poorly differentiated HCC in HCV-associated liver cirrhosis. (22989817)
2012
16
Cognitive functions in patients with liver cirrhosis: assessment using community screening interview for dementia. (23103921)
2012
17
Acute management of refractory variceal bleeding in liver cirrhosis by self-expanding metal stents. (22269340)
2012
18
PFA-100 test in the detection of platelet dysfunction and monitoring DDAVP in a patient with liver cirrhosis undergoing inguinal hernia repair. (23350257)
2012
19
Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis. (22271046)
2012
20
Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease. (21334404)
2011
21
Arginine vasopressin (AVP) and treatment with arginine vasopressin receptor antagonists (vaptans) in congestive heart failure, liver cirrhosis and syndrome of inappropriate antidiuretic hormone secretion (SIADH). (21327910)
2011
22
Assessment of liver fibrosis and cirrhosis by aspartate aminotransferase-to-platelet ratio index in children with biliary atresia. (20531020)
2010
23
Impact of antithrombin III concentrates on portal vein thrombosis after splenectomy in patients with liver cirrhosis and hypersplenism. (19864937)
2010
24
Dobutamine stress echocardiography for evaluating cirrhotic cardiomyopathy in liver cirrhosis. (21415581)
2010
25
Plasma levels of PBEF/Nampt/visfatin are decreased in patients with liver cirrhosis. (19074645)
2009
26
Reelin is overexpressed in the liver and plasma of bile duct ligated rats and its levels and glycosylation are altered in plasma of humans with cirrhosis. (18449964)
2008
27
Elevated plasma resistin concentrations in patients with liver cirrhosis. (18171344)
2008
28
ILK overexpression in human hepatocellular carcinoma and liver cirrhosis correlates with activation of Akt. (19020711)
2008
29
Recurrence of primary biliary cirrhosis and primary sclerosing cholangitis after liver transplantation in Japan. (17931201)
2007
30
Biochemical markers, extracellular components in liver fibrosis and cirrhosis. (17688172)
2007
31
Does autonomic dysfunction in cirrhosis liver influence variceal bleed? (17519833)
2007
32
Nonalcoholic fatty liver disease: from steatosis to cirrhosis. (16447287)
2006
33
Impact of antithrombin III on hepatic and intestinal microcirculation in experimental liver cirrhosis and bowel inflammation: an in vivo analysis. (16124052)
2005
34
Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma. (15511635)
2004
35
Plasma thrombopoietin level and its influence on megakaryocytopoiesis in end-stage liver cirrhosis and uremia patients]. (12513730)
2002
36
Serum thrombopoietin levels in patients with chronic hepatitis and liver cirrhosis, and its relationship with circulating thrombocyte counts. (12397754)
2002
37
Activation of blood platelets in chronic hepatitis and liver cirrhosis P-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and platelet factor-4. (11462931)
2001
38
Antiviral therapy of HBV- and HCV-induced liver cirrhosis. (10777179)
2000
39
Protein expression of double-stranded RNA-activated protein kinase (PKR) in intrahepatic bile ducts in normal adult livers, fetal livers, primary biliary cirrhosis, hepatolithiasis and intrahepatic cholangiocarcinoma. (11169059)
2000
40
Serum and ascitic levels of soluble intercellular adhesion molecule-1 in patients with alcoholic liver cirrhosis: relation to biochemical markers of disease activity and alcohol intake. (8865970)
1996
41
Liver cirrhosis associated with heterozygous alpha-1-antitrypsin deficiency type Pi MS and autoimmune features. (7895931)
1995
42
Single hepatocellular carcinoma (phi < or = 5 cm) in liver cirrhosis. Early diagnosis and surgical removal]. (8269741)
1993
43
Peptic ulcer surgery in patients with liver cirrhosis. (8466308)
1993
44
Disseminated intravascular coagulation in liver cirrhosis. (1447499)
1992
45
Polymorphism of alcohol dehydrogenase, alcohol and aldehyde dehydrogenase activities: implication in alcoholic cirrhosis in white patients. The French Group for Research on Alcohol and Liver. (1592339)
1992
46
Studies on the monocyte interleukin-1 and tumour necrosis factor-alpha production in patients with alcoholic liver cirrhosis. (2636361)
1989
47
Depressed monocyte production of interleukin-1 and tumor necrosis factor-alpha in patients with alcoholic liver cirrhosis. (2586242)
1989
48
Pneumococcal vaccination: the response of patients with alcoholic liver cirrhosis. (6479858)
1984
49
Endoscopic non-aggressive assessment of oesophageal variceal pressure compared with wedged hepatic venous pressure in alcoholic liver cirrhosis. (6872963)
1983
50
Intestinal lymphangiectasia in liver cirrhosis. (5598103)
1967

Genetic Variations for Liver Cirrhosis

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Expression for genes affiliated with Liver Cirrhosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Liver Cirrhosis

Search GEO for disease gene expression data for Liver Cirrhosis.

Pathways for genes affiliated with Liver Cirrhosis

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore
See all sources

Pathways related to Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.3NAT2, TAT, GPT, PLIN2, ALDH2, ALB
2
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11.2AKR1A1, CYP2E1, CYP2A6, NAT2, ALDH2, ADH1C
3
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11.1ADH1B, ADH1C, ALDH2, CYP2A6, CYP2E1, AKR1A1
4
Hide members
11.0ADH1B, ADH1C, NAT2, CYP2A6, CYP2E1
510.9TAT, F2, TTR, ALB
6
Hide members
10.9AKR1A1, ALDH2, ADH1C, ADH1B
7
Hide members
10.9AKR1A1, CYP2A6, ALDH2, ADH1B
8
Hide members
10.8ADH1B, ADH1C, ALDH2
9
Hide members
10.8ALDH2, ADH1C, ADH1B
10
Hide members
10.8CYP2E1, ALDH2, ADH1B
11
Hide members
10.8CYP2E1, CYP2A6, ADH1B
12
Retinol metabolism
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10.8ALDH2, CYP2A6, CYP2E1
13
Hide members
10.8NAT2, CYP2A6, CYP2E1
14
Acetaminophen metabolism
Hide members
10.8CYP2E1, CYP2A6, NAT2
15
Naphthalene metabolism
Hide members
10.8CYP2A6, CYP2E1, AKR1A1
16
Hide members
10.7ADH1B, ADH1C
17
Hide members
10.7ADH1B, ALDH2

Compounds for genes affiliated with Liver Cirrhosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Liver Cirrhosis according to GeneCards/GeneDecks:

(show top 50)    (show all 231)
idCompoundScoreTop Affiliating Genes
1ethanol44 49 11 2415.2GPT, HGF, LSL, TAT, CYP2E1, AKR1A1
2aspartate4412.2HGF, IFNA1, LSL, AKR1A1, GHRH, ALDH2
3vitamin a44 11 2414.1GPT, NAT2, IGFBP3, AKR1A1, HGF, CYP2E1
4alanine4412.0TAT, IGFBP3, ALDH2, AKR1A1, GPT, F2
5lactate4411.9AKR1A1, LSL, ALB, GPT, HGF, TTR
6creatinine4411.9LSL, ALDH2, TTR, F2, GPT, CYP2E1
7glycerol44 11 2413.8ADH1B, LSL, IGFBP3, CYP2E1, AKR1A1, TAT
8testosterone44 59 11 2414.8CYP2A6, CYP2E1, GHRH, LSL, TTR, HGF
9cholesterol44 28 11 2414.8PLIN2, TTR, LSL, GHRH, IGFBP3, NAT2
10prednisolone44 28 1113.7TAT, IGFBP3, LSL, ALB, IFNA1, HGF
11methotrexate44 49 1113.7NAT2, IGFBP3, GPT, LSL, HGF, TAT
12arginine4411.7ALDH2, GHRH, IGFBP3, TAT, TTR, GPT
13lipid4411.7HGF, LSL, TAT, GHRH, AKR1A1, ALB
14dopamine44 28 11 2414.7AKR1A1, ADH1B, CYP2A6, TAT, CYP2E1, TTR
15rsai4411.6LSL, AKR1A1, CYP2E1, NAT2, ALDH2, ADH1C
16acetaldehyde44 28 2413.6HGF, AKR1A1, CYP2E1, ADH1B, CYP2A6, ADH1C
17dexamethasone44 49 28 1114.6TAT, HGF, IFNA1, GHRH, CYP2E1, CYP2A6
18folate4411.6TTR, NAT2, HGF, AKR1A1, ALDH2, ALB
19vitamin d4411.5GHRH, GPT, HGF, AHSG, TTR, ALB
20glucose4411.5GHRH, LSL, ADH1B, IGFBP3, ALDH2, AHSG
21fibrinogen4411.5LSL, ALB, GPT, F2, TTR, TAT
22valproic acid44 49 11 2414.5CYP2A6, ALB, LSL, IGFBP3, GPT, CYP2E1
23rosiglitazone44 49 28 11 2415.5PLIN2, GPT, CYP2A6, IGFBP3, LSL, ALB
24thyroxine44 2412.4LSL, ALB, IGFBP3, GHRH, GPT, TTR
25hyaluronic acid44 2412.4HGF, IGFBP3, GPT, F2, TTR, ALB
26disulfiram44 59 1113.4AKR1A1, GPT, CYP2A6, ALDH2, CYP2E1
27ursodeoxycholic acid44 11 2413.4F2, GPT, CYP2E1, HGF, IFNA1
28tamoxifen44 49 28 1114.3GHRH, LSL, IFNA1, CYP2E1, CYP2A6
29rifampicin44 28 5913.3NAT2, TAT, CYP2A6, CYP2E1, GPT
30Fomepizole1111.3CYP2E1, CYP2A6, ADH1C, ADH1B
31hepaplastin4411.3ALB, F2, HGF, GPT
32acetaminophen44 2 49 11 2415.3GPT, CYP2A6, CYP2E1, NAT2
33retinoic acid44 2412.3IGFBP3, ALDH2, TTR, TAT, CYP2A6, CYP2E1
34estradiol44 11 2413.3CYP2E1, CYP2A6, TAT, GHRH
35dimethylnitrosamine4411.3NAT2, HGF, CYP2E1, CYP2A6
36glutamate4411.3GPT, GHRH, AKR1A1, ALDH2, TAT
37betacarotene4411.2CYP2E1, IGFBP3, TTR, ALDH2, NAT2
38trichloroethylene4411.2CYP2E1, GPT, NAT2, AKR1A1
39pyrazole44 1112.2CYP2A6, AKR1A1, CYP2E1, ADH1C
40estrogen4411.2AHSG, TTR, TAT
41triiodothyronine4411.1HGF, LSL, GHRH, TTR, IGFBP3
42nash4411.1CYP2E1, AKR1A1, LSL, GPT
43antipyrine44 1112.1CYP2A6, ALB, F2, CYP2E1
44sevoflurane44 1112.1ALB, GPT, CYP2A6, CYP2E1
45phenobarbital44 28 1113.1GPT, AKR1A1, CYP2E1, CYP2A6, HGF
46isoniazid49 44 1113.0GPT, CYP2A6, NAT2, CYP2E1
47zidovudine44 1112.0IFNA1, CYP2A6, TAT, GPT, ALB
48warfarin44 49 11 2414.0NAT2, CYP2A6
49cyclosporin a44 28 5912.9F2, TTR, GPT, TAT, IGFBP3, IFNA1
504-methylpyrazole4410.8CYP2A6, AKR1A1, CYP2E1

GO Terms for genes affiliated with Liver Cirrhosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Liver Cirrhosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.3HGF, GHRH, IGFBP3, AHSG, F2, TTR
2extracellular spaceGO:00561510.9HGF, GHRH, IGFBP3, AHSG, F2, TTR

Biological processes related to Liver Cirrhosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.5ALB, ALDH2, ADH1C, GPT, TAT, NAT2
2xenobiotic metabolic processGO:00680511.2CYP2E1, CYP2A6, NAT2, ALDH2, ADH1C, ADH1B
3ethanol oxidationGO:00606910.7ADH1B, ALDH2, ADH1C
4positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.7GHRH, IGFBP3
5response to mercury ionGO:04668910.4ALB, TAT

Molecular functions related to Liver Cirrhosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1electron carrier activityGO:00905510.8ALDH2, CYP2A6, CYP2E1, AKR1A1
2oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:01671210.7CYP2A6, CYP2E1
3pyridoxal phosphate bindingGO:03017010.5ALB, GPT, TAT

Products for genes affiliated with Liver Cirrhosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Liver Cirrhosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet