MCID: LVR012
MIFTS: 75

Liver Cirrhosis malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Liver Cirrhosis

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Cirrhosis is scarring of the liver. scar tissue forms because of injury or long-term disease. scar tissue cannot do what healthy liver tissue does - make protein, help fight infections, clean the blood, help digest food and store energy. cirrhosis can lead to easy bruising or bleeding, or nosebleeds swelling of the abdomen or legs extra sensitivity to medicines high blood pressure in the vein entering the liver enlarged veins called varices in the esophagus and stomach. varices can bleed suddenly. kidney failure jaundice severe itching gallstones a small number of people with cirrhosis get liver cancer. your doctor will diagnose cirrhosis with blood tests, imaging tests, or a biopsy. cirrhosis has many causes. in the united states, the most common causes are chronic alcoholism and hepatitis. nothing will make the scar tissue disappear, but treating the cause can keep it from getting worse. if too much scar tissue forms, you may need to consider a liver transplant. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Liver Cirrhosis, also known as cirrhosis, is related to alcoholic liver cirrhosis and hepatitis. An important gene associated with Liver Cirrhosis is ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide), and among its related pathways are Abacavir Pathway, Pharmacokinetics/Pharmacodynamics and Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics. The drugs bumetanide and ethacrynate sodium and the compounds hepaplastin and antipyrine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related mouse phenotypes are liver/biliary system and reproductive system.

Wikipedia:66 Cirrhosis /s??ro?s?s/ (from Greek kirrhos [??????] \"yellowish\" and the common Greek suffix -sis... more...

Aliases & Classifications for Liver Cirrhosis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

liver cirrhosis 9 11 46 32 63
cirrhosis 9 46 35 63
cirrhosis of liver nos 9
cirrhosis of liver 9


External Ids:

Disease Ontology9 DOID:5082
NCIt41 C2951
MeSH36 D008103

Related Diseases for Liver Cirrhosis

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Liver Cirrhosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 548)
idRelated DiseaseScoreTop Affiliating Genes
1alcoholic liver cirrhosis31.9GPT, HGF
2hepatitis31.6CYP2E1, F2, GPT, TGFB1, ASGR2, TAT
3portal hypertension31.3F2, GPT, ALB
4hypertension31.2ALB, TGFB1, F2
5hepatitis b31.2F2, GPT, TGFB1, ASGR2, ALB
6hepatitis c31.2F2, CYP2E1, GPT, TGFB1, ASGR2
7hepatic encephalopathy31.1F2, GPT, ALB
8hepatocellular carcinoma31.1TAT, ALDH2, ALB, HGF, AKR1A1, ASGR2
9hypersplenism31.0F2
10hepatorenal syndrome30.8ALB, F2
11pancreatitis30.8CYP2E1, TGFB1, ADH1C, ADH1B, ALB, ALDH2
12thrombocytopenia30.6F2, GPT, ALB
13choledocholithiasis30.5GPT
14viral hepatitis30.5F2, CYP2A6, GPT, ADH1B, AKR1A1
15protein-energy malnutrition30.5ALB, TTR
16autoimmune hepatitis30.5F2, GPT, ASGR2
17insulin resistance30.4IGFBP3, CYP2E1, AHSG, GPT, TTR, ALB
18primary biliary cirrhosis30.4F2, GPT, ASGR2, ALB
19siderosis30.4GPT
20diabetes mellitus30.4IGFBP3, CYP2E1, AHSG, GPT, TGFB1, NAT2
21tuberculosis30.3CYP2A6, CYP2E1, NAT2, AKR1A1, ALB, TAT
22alcoholic hepatitis30.3F2, GPT, ALB
23acute liver failure30.3F2, GPT, HGF, ALB
24leukopenia30.3ALB, GPT, F2
25obstructive jaundice30.3GPT, TTR, AKR1A1
26hepatitis e30.3GPT
27alcoholic pancreatitis30.2CYP2E1, ADH1C, ADH1B, AKR1A1, ALDH2
28alcohol abuse30.2CYP2E1, GPT, ADH1C, AKR1A1, ALDH2
29connective tissue disease30.2ALB, TGFB1, F2
30fatty liver disease30.2CYP2A6, CYP2E1, AHSG, GPT, PLIN2, ALDH2
31dysfibrinogenemia30.2F2
32hepatitis a30.2F2
33osteoporosis30.1TGFB1, AHSG, IGFBP3
34alcohol dependence30.1ALDH2, ADH1B
35varicose veins30.1ALB, F2
36cholestasis30.1F2, GPT, ALB
37esophageal cancer30.1CYP2E1, ADH1B, ALDH2
38pulmonary embolism30.1F2, ALB
39cholangitis30.1GPT, ALB
40acute pancreatitis30.1GPT, ADH1C, ADH1B, ALDH2
41biliary atresia30.0HGF, TGFB1, GPT
42lung cancer30.0CYP2E1, TGFB1, GHRH, HGF
43autonomic neuropathy30.0ALB, TTR
44adenoma30.0GHRH, ADH1C, NAT2, CYP2A6, IGFBP3
45proteinuria29.9TTR, TGFB1, ALB
46vasculitis29.9F2, ALB, TAT
47colon cancer29.8IGFBP3, CYP2A6, NAT2, HGF, TAT
48obesity29.8IGFBP3, CYP2A6, CYP2E1, AHSG, GPT, PLIN2
49adenocarcinoma29.7CYP2A6, CYP2E1, TGFB1, NAT2, ADH1C, ADH1B
50galactosemia29.7F2, GPT, HGF, ALB

Graphical network of the top 20 diseases related to Liver Cirrhosis:



Diseases related to liver cirrhosis

Symptoms for Liver Cirrhosis

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Drugs & Therapeutics for Liver Cirrhosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Liver Cirrhosis

Drug clinical trials:

Search ClinicalTrials for Liver Cirrhosis

Search NIH Clinical Center for Liver Cirrhosis

Search CenterWatch for Liver Cirrhosis

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Liver Cirrhosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Liver Cirrhosis:
Autologous bone marrow-derived mesenchymal stem cells for liver cirhosis
Autologous bone marrow-derived stem cells for treatment of liver cirrhosis
Autologous hematopoietic stem cells for treatment of end-stage chronic liver disease
Bone marrow-derived endothelial progenitor cells for advanced liver cirrhosis
Bone marrow-derived mesenchymal stem cells for treatment of cirrhosis-related refractory ascites
Bone marrow-derived mesenchymal stem cells for treatment of liver cirrhosis
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Mesenchymal stem cells for liver cirrhosis
NU215-01, human umbilical cord mesenchymal stem cells for treatment of liver cirrhosis
Peripheral blood-derived CD34+ or mononuclear cells for liver cirrhosis
StempeucelLC
Umbilical cord-derived mesenchymal stem cells for treatment of liver cirrhosis
Embryonic/Adult Cultured Cells Related to Liver Cirrhosis:
Bone marrow-derived mesenchymal stem cells (family), PMIDs: 21771778, 22121493
Bone marrow-derived mesenchymal stem cells (family), PMID: 22121493
Peripheral blood-derived hematopoietic stem cells, PMID: 20587151
Bone marrow-derived endothelial progenitor cells (family)
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells (family)
Hepatocytes
Bone marrow-derived mesenchymal stem cells (family)
Umbilical cord-derived mesenchymal stem cells
Peripheral blood-derived mesenchymal stem cells (family)
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444
Umbilical cord-derived mesenchymal stem cells (family)

Genetic Tests for Liver Cirrhosis

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Anatomical Context for Liver Cirrhosis

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Liver Cirrhosis:

34
Liver, Bone, Testes, Kidney, Bone marrow, Endothelial, Heart, Spleen, Monocytes, T cells, Small intestine, Thyroid, Prostate, Colon, B cells, Pituitary, Lung, Brain, Pancreas, Skin

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Liver Cirrhosis:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
3 LiverSinusoidsHepatic Stellate Cells Affected by disease
4 LiverLiver LobuleHepatocytes Affected by disease
5 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
6 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Liver Cirrhosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Liver Cirrhosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.8IGFBP3, CYP2E1, TGFB1, PLIN2, GHRH, HGF
2MP:00053897.4F2, TGFB1, NAT2, AKR1A1, PLIN2, GHRH
3MP:00053787.3F2, IGFBP3, AHSG, TGFB1, ADH1C, PLIN2
4MP:00107687.1CYP2E1, TGFB1, ADH1C, ASGR2, AKR1A1, HGF
5MP:00053765.1ALDH2, F2, IGFBP3, CYP2E1, AHSG, TTR

Publications for Liver Cirrhosis

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Sources:
53PubMed
See all sources

Articles related to Liver Cirrhosis:

(show top 50)    (show all 1315)
idTitleAuthorsYear
1
Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis. (24424503)
2014
2
Predictive factors that influence the survival rates in liver cirrhosis patients with spontaneous bacterial peritonitis. (23837137)
2013
3
Clinical significance of therapy using branched-chain amino acid granules in patients with liver cirrhosis and hepatocellular carcinoma. (23819582)
2013
4
Immediate effects of different schedules of somatostatin on portal pressure in patients with liver cirrhosis. (23437909)
2013
5
Assessment of Clinical Signs of Liver Cirrhosis Using T1 Mapping on Gd-EOB-DTPA-Enhanced 3T MRI. (24392025)
2013
6
Liver cirrhosis treated by living donor liver transplantation in a patient with AGL mutation c.2607-2610delATTC and c.1672dupA. (23688858)
2013
7
Small bowel abnormalities in patients with compensated liver cirrhosis. (23247799)
2013
8
A case of variceal bleeding from the jejunum in liver cirrhosis. (23593613)
2013
9
Metabonomic profiles discriminate hepatocellular carcinoma from liver cirrhosis by ultraperformance liquid chromatography-mass spectrometry. (22200553)
2012
10
Different patterns of decompensation in patients with alcoholic vs. non-alcoholic liver cirrhosis. (22530565)
2012
11
Psychometric hepatic encephalopathy score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis. (22743001)
2012
12
MR relaxometry of the liver: significant elevation of T1 relaxation time in patients with liver cirrhosis. (22302503)
2012
13
Comparison of hepatic venous pressure gradient and two models of end-stage liver disease for predicting the survival in patients with decompensated liver cirrhosis. (22810110)
2012
14
Hepatitis surface antigen clearance in a woman with liver cirrhosis and concomitant autoimmune hepatitis under immunosuppressive therapy. (23181542)
2012
15
Obstructive jaundice due to ductus hepaticus communis cyst in patient with liver cirrhosis. (22156359)
2011
16
Induction of blood lymphocyte cytochrome P450 2E1 in early stage alcoholic liver cirrhosis. (20843640)
2011
17
Lack of an association between -308G>A polymorphism of the TNF-I+ gene and liver cirrhosis risk based on a meta-analysis. (22095602)
2011
18
Scrub typhus in patients with liver cirrhosis: a preliminary study. (19624507)
2010
19
Expression of p53 protein in liver and sera of patients with liver fibrosis, liver cirrhosis or hepatocellular carcinoma associated with chronic HCV infection. (19063876)
2009
20
Altered basal and postprandial plasma melatonin, gastrin, ghrelin, leptin and insulin in patients with liver cirrhosis and portal hypertension without and with oral administration of melatonin or tryptophan. (19552764)
2009
21
Clinical and morphological characteristics and some mechanisms of portal gastroduodenopathy in liver cirrhosis]. (20469678)
2009
22
Alcohol abstinence and orthotopic liver transplantation in alcoholic liver cirrhosis. (19460531)
2009
23
UDP-glucuronosyltransferase 1A7 polymorphisms are associated with liver cirrhosis. (18054330)
2008
24
A clinical study of thymosin alpha1 as an auxiliary in treating spontaneous peritonitis in patients with liver cirrhosis]. (17407720)
2007
25
The association of TGF beta1 and AT1R gene polymorphisms with hereditary susceptibility and clinical phenotype of HBV-induced liver cirrhosis]. (17557241)
2007
26
Incidence and factors predictive of acute renal failure in patients with advanced liver cirrhosis. (16429839)
2006
27
Development of cell therapy using autologous bone marrow cells for liver cirrhosis. (16378227)
2005
28
Osteoprotegerin and RANKL in alcoholic liver cirrhosis. (15780054)
2005
29
Elevated circulating adiponectin levels in liver cirrhosis are associated with reduced liver function and altered hepatic hemodynamics. (15010338)
2004
30
Unique hypervascular nodules in alcoholic liver cirrhosis: identical to focal nodular hyperplasia-like nodules? (15582133)
2004
31
Liver cirrhosis due to chronic use of nitrofurantoin]. (14983581)
2004
32
The Bcl-2 and TGF-beta1 levels in patients with chronic hepatitis C, liver cirrhosis and hepatocellular carcinoma. (15724390)
2004
33
Expression of gap junction protein connexin32 in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. (15338370)
2004
34
High ascitic fluid leptin levels in patients with decompensated liver cirrhosis and sterile ascites: relationship with TNF-alpha levels. (15104370)
2004
35
Progastrin and its products from patients with chronic viral hepatitis and liver cirrhosis. (12825873)
2003
36
Elevation of serum and ascites cancer antigen 125 levels in patients with liver cirrhosis. (14535990)
2003
37
Polymorphisms in the DNA repair gene XRCC1 and susceptibility to alcoholic liver cirrhosis in older Southeastern Brazilians. (12175549)
2002
38
Mechanisms of endotoxin tolerance in patients with alcoholic liver cirrhosis: role of interleukin 10, interleukin 1 receptor antagonist, and soluble tumour necrosis factor receptors as well as effector cell desensitisation. (10896923)
2000
39
Therapy of acute variceal hemorrhage and spontaneous bacterial peritonitis in liver cirrhosis]. (9789469)
1998
40
Growth hormone-stimulated insulin-like growth factor (IGF) I and IGF-binding protein-3 in liver cirrhosis. (9382965)
1997
41
Hepatic stellate cells and intralobular innervation in human liver cirrhosis. (9269832)
1997
42
Serum and ascitic levels of soluble intercellular adhesion molecule-1 in patients with alcoholic liver cirrhosis: relation to biochemical markers of disease activity and alcohol intake. (8865970)
1996
43
Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats. (8690730)
1995
44
Effects of alcohol and liver cirrhosis on the GH-IGF-I axis. (8679009)
1995
45
Predictive analysis of the response to treatment with diuretics of patients with liver cirrhosis and ascites]. (8562191)
1995
46
Anesthetic management for a patient with citrullinemia and liver cirrhosis]. (7699832)
1995
47
Endogenous digitalis-like factor in liver cirrhosis and cholestasis]. (7483706)
1993
48
Disseminated intravascular coagulation in liver cirrhosis. (1447499)
1992
49
Mechanism of feminization in male patients with non-alcoholic liver cirrhosis: role of sex hormone-binding globulin. (1916151)
1991
50
Reticuloendothelial function in patients with alcoholic liver cirrhosis. (7323686)
1981

Variations for Liver Cirrhosis

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Expression for genes affiliated with Liver Cirrhosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Liver Cirrhosis

Search GEO for disease gene expression data for Liver Cirrhosis.

Pathways for genes affiliated with Liver Cirrhosis

About this section
Sources:
51PathCards, 52PharmGKB, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters, 54QIAGEN
See all sources

Pathways related to Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ADH1B, ADH1C
29.9CYP2E1, CYP2A6
39.9CYP2E1, CYP2A6
49.8IGFBP3, F2
5
Show member pathways
mitochondrial L-carnitine shuttle pathway39
Saturated fatty acid biosynthesis61
9.8ADH1C, ADH1B, ALDH2
6
Show member pathways
acetate conversion to acetyl-CoA39
oxidative ethanol degradation III39
ethanol degradation IV39
9.7CYP2E1, ADH1B, ALDH2
7
Show member pathways
bupropion degradation39
methylglyoxal degradation III39
nicotine degradation III39
nicotine degradation IV39
9.7ADH1B, CYP2E1, CYP2A6
89.6TGFB1, HGF
9
Show member pathways
Retinol metabolism61
9.6ALDH2, CYP2E1, CYP2A6
109.5CYP2A6, CYP2E1, NAT2
11
Show member pathways
9.5CYP2A6, CYP2E1, NAT2
12
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
9.5TAT, ALDH2, ADH1B, ADH1C
13
Show member pathways
9.5ALDH2, NAT2, CYP2A6
14
Show member pathways
9.4ALB, HGF, TGFB1
159.4CYP2A6, CYP2E1, AKR1A1
169.3F2, TTR, ALB, TAT
17
Show member pathways
glycolysis39
gluconeogenesis39
Glycolysis and Gluconeogenesis39
9.2ADH1C, ADH1B, AKR1A1, ALDH2
18
Show member pathways
9.2ADH1C, ADH1B, AKR1A1, ALDH2
19
Show member pathways
9.2F2, TGFB1, GHRH, HGF
20
Show member pathways
9.2CYP2A6, CYP2E1, ADH1C, ADH1B, ALDH2
21
Show member pathways
9.1CYP2A6, CYP2E1, NAT2, ADH1C, ADH1B
22
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)39
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA39
tryptophan degradation39
glutaryl-CoA degradation39
serotonin degradation39
NAD de novo biosynthesis39
superpathway of melatonin degradation39
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde39
tryptophan utilization I39
melatonin degradation I39
9.1ALDH2, AKR1A1, ADH1B, CYP2A6
23
Show member pathways
8.3ALDH2, CYP2A6, CYP2E1, NAT2, ADH1C, ADH1B
24
Show member pathways
6.9CYP2A6, CYP2E1, GPT, NAT2, ADH1C, ADH1B

Compounds for genes affiliated with Liver Cirrhosis

About this section
Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Liver Cirrhosis according to GeneCards/GeneDecks:

(show top 50)    (show all 275)
idCompoundScoreTop Affiliating Genes
1hepaplastin469.9GPT, F2, HGF, ALB
2antipyrine46 1210.6ALB, CYP2E1, CYP2A6, F2
3sevoflurane52 46 1211.6CYP2E1, CYP2A6, GPT, ALB
4dimethylnitrosamine469.6NAT2, CYP2A6, CYP2E1, HGF
5pyrazole46 1210.5CYP2E1, ADH1C, AKR1A1, CYP2A6
6trichloroethylene469.5AKR1A1, GPT, NAT2, CYP2E1
7warfarin46 52 25 1212.4ALB, NAT2, GPT, CYP2A6, F2
8isoniazid46 52 1211.3NAT2, GPT, CYP2E1, CYP2A6
9rifampicin46 30 6211.3TAT, CYP2A6, NAT2, CYP2E1, GPT
10disulfiram46 52 62 1212.2CYP2A6, AKR1A1, ALDH2, GPT, CYP2E1
11nash469.2AKR1A1, CYP2E1, GPT, TGFB1
12acetaminophen46 3 52 25 1213.2CYP2E1, CYP2A6, NAT2, HGF, F2, GPT
13rsai469.1ALDH2, AKR1A1, NAT2, ADH1B, ADH1C, CYP2E1
14zidovudine46 52 1211.0ALB, CYP2A6, GPT, TGFB1, TAT
15NADP259.0CYP2A6, ALDH2, AKR1A1, ADH1B, ADH1C, CYP2E1
16prednisolone46 30 1211.0ALB, HGF, GPT, CYP2A6, IGFBP3, TAT
17theophylline46 30 25 1212.0GHRH, TGFB1, TTR, CYP2E1, CYP2A6
18valproic acid46 52 25 1211.9IGFBP3, ALB, GPT, CYP2E1, CYP2A6
19phenobarbital46 30 52 1211.9CYP2A6, AKR1A1, CYP2E1, HGF, GPT
20acetaldehyde30 46 2510.8CYP2A6, CYP2E1, ADH1C, ADH1B, ALDH2, AKR1A1
21thyroxine46 259.7GPT, TGFB1, GHRH, TTR, IGFBP3, ALB
22formaldehyde46 259.7ADH1C, CYP2A6, CYP2E1, TGFB1, AKR1A1, ALDH2
23betacarotene468.6IGFBP3, CYP2E1, TTR, TGFB1, NAT2, ALDH2
24estradiol46 25 1210.6CYP2E1, GHRH, CYP2A6, TAT, HGF, IGFBP3
25alpha tocopherol468.5TTR, ALB, ALDH2, IGFBP3, GPT
26hyaluronic acid46 259.5TGFB1, TTR, GPT, IGFBP3, F2, HGF
27rosiglitazone30 46 52 25 1212.4IGFBP3, PLIN2, CYP2A6, GPT, TGFB1, ALB
28dopamine46 30 25 1211.3ALDH2, GHRH, AKR1A1, ADH1B, TTR, CYP2E1
29cyclosporin a46 30 6210.3F2, IGFBP3, TGFB1, HGF, GPT, TTR
30methotrexate52 46 1210.3F2, NAT2, TAT, ALB, HGF, TGFB1
31folate468.2HGF, TTR, ALDH2, ALB, IGFBP3, NAT2
32vitamin d468.2ALB, HGF, GHRH, TGFB1, TTR, GPT
33testosterone46 62 25 1211.2ALB, TAT, IGFBP3, GHRH, HGF, TTR
34glycerol46 25 1210.0CYP2E1, TAT, PLIN2, AKR1A1, ADH1B, IGFBP3
35cholesterol46 30 25 1210.9GHRH, ALB, TTR, PLIN2, NAT2, GPT
36glutamine467.8TAT, IGFBP3, GPT, TTR, ALDH2, HGF
37glutamate467.7IGFBP3, ALDH2, HGF, GHRH, AKR1A1, TTR
38arginine467.7HGF, GHRH, TTR, GPT, ALDH2, TAT
39aspartate467.7IGFBP3, HGF, F2, TAT, ALDH2, GPT
40cysteine467.7TTR, ALDH2, TAT, AHSG, ALB, AKR1A1
41dexamethasone46 52 30 1210.7TGFB1, TTR, CYP2E1, CYP2A6, IGFBP3, TAT
42glucose467.6AHSG, TTR, PLIN2, GHRH, ALB, TAT
43lactate467.5GPT, CYP2E1, TAT, TTR, AKR1A1, HGF
44creatinine467.4IGFBP3, AKR1A1, ALB, ALDH2, HGF, TGFB1
45alanine467.4F2, IGFBP3, TTR, HGF, ALB, ALDH2
46vitamin a46 25 129.4ALB, ALDH2, IGFBP3, AKR1A1, ADH1B, ADH1C
47retinoic acid46 258.4AKR1A1, TGFB1, TTR, CYP2E1, CYP2A6, IGFBP3
48lipid467.3CYP2E1, GPT, AKR1A1, PLIN2, GHRH, HGF
49ethanol46 52 25 1210.3AKR1A1, ALDH2, GHRH, TAT, CYP2E1, AHSG
50estrogen467.3AHSG, TTR, TGFB1, NAT2, AKR1A1, GHRH

GO Terms for genes affiliated with Liver Cirrhosis

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Sources:
17Gene Ontology
See all sources

Cellular components related to Liver Cirrhosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.4ALB, HGF, TGFB1
2blood microparticleGO:0725629.0F2, AHSG, TGFB1, ALB
3extracellular spaceGO:0056157.3ALB, F2, IGFBP3, AHSG, TTR, TGFB1
4extracellular regionGO:0055767.1F2, IGFBP3, AHSG, TTR, TGFB1, PLIN2

Biological processes related to Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1response to mercury ionGO:04668910.0TAT, ALB
2ethanol oxidationGO:0060699.9ADH1C, ADH1B, ALDH2
3positive regulation of collagen biosynthetic processGO:0329679.8TGFB1, F2
4positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.7GHRH, IGFBP3
5platelet degranulationGO:0025769.4TGFB1, HGF, ALB
6platelet activationGO:0301689.3ALB, HGF, TGFB1, F2
7xenobiotic metabolic processGO:0068059.0ALDH2, CYP2A6, CYP2E1, NAT2, ADH1C, ADH1B
8blood coagulationGO:0075968.9ALB, HGF, TGFB1, F2
9small molecule metabolic processGO:0442817.6CYP2A6, CYP2E1, GPT, NAT2, ADH1C, ADH1B

Molecular functions related to Liver Cirrhosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:0301709.7TAT, ALB, GPT
2oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenGO:0167129.6CYP2E1, CYP2A6
3growth factor activityGO:0080839.4HGF, TGFB1, F2
4enzyme bindingGO:0198999.0CYP2A6, CYP2E1, TGFB1, ALB

Products for genes affiliated with Liver Cirrhosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Liver Cirrhosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet