Liver Cirrhosis malady

MedlinePlus: Cirrhosis is scarring of the liver. scar tissue forms because of injury or long-term disease. scar tissue cannot do what healthy liver tissue does - make protein, help fight infections, clean the blood, help digest food and store energy. cirrhosis can lead to easy bruising or bleeding, or nosebleeds swelling of the abdomen or legs extra sensitivity to medicines high blood pressure in the vein entering the liver enlarged veins in the esophagus and stomach kidney failure about 5 percent of people with cirrhosis get liver cancer. cirrhosis has many causes. in the united states, the most common causes are chronic alcoholism and hepatitis. nothing will make the scar tissue disappear, but treating the cause can keep it from getting worse. if too much scar tissue forms, you may need to consider a liver transplant. nih: national institute of diabetes and digestive and kidney diseases²³

MalaCards: Liver Cirrhosis, also known as cirrhosis, is related to hepatitis and primary biliary cirrhosis. An important gene associated with Liver Cirrhosis is PLIN2 (perilipin 2), and among its related pathways are Metabolic pathways and mTOR Pathway. The drugs bumetanide and furosemide and the compounds calcium and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Wikipedia: Cirrhosis (pron.: /sɪˈroʊsɪs/) is a consequence of chronic liver disease characterized by...⁴⁴ more...

Aliases & Descriptions:

liver cirrhosis 6 8 32 43 cirrhosis 6 7 17 32 23 43 cirrhosis of liver nos (disorder) 6

cirrhosis of liver (disorder) 6 cirrhosis of liver nos 6

Diseases related to liver cirrhosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1011)

id	Related Disease	Score	Top Affiliating Genes
1	hepatitis	42.3	RBP4, SELP, SERPINA1, VIPR1, XDH, ASGR2
2	primary biliary cirrhosis	41.6	BGLAP, SCT, CETP, CD79A, ASGR2, GZMB
3	carcinoma	40.7	PDE4A, REG1A, REN, RETN, CNR1, GCK
4	alcoholism	40.1	CNR1, SCT, CFTR, IL1RN, GPT, ALDH2
5	alcoholic liver cirrhosis	39.6	NAT2, LCAT, GSTM1, IL8, GPT, F2
6	hepatocellular carcinoma	37.3	REG1A, CNR1, BTD, RB1, RBP4, SELE
7	hepatitis c	36.7	SERPINA1, VIPR1, JUN, MMP1, ASGR2, IRF7
8	hepatitis b	36.3	ASGR2, IL10, IL17A, IL18, IL2RA, MBL2
9	portal hypertension	35.4	RETN, CNR1, UTS2, GPT, F2, ALB
10	autoimmune hepatitis	34.7	CD14, ASGR2, GSTT1, FAS, GPT, IFNA1
11	viral hepatitis	33.7	SERPINC1, SERPINA1, SERPINA3, BGLAP, LEP, LEPR
12	hypertension	33.5	PDE4A, REN, RETN, CNR1, GCK, RBP4
13	hepatic encephalopathy	33.4	GC, ASS1, IL18, IL6, GPT, F2
14	fatty liver disease	33.1	RETN, CNR1, RBP4, SERPINE1, NAMPT, BHMT
15	jaundice	32.3	REN, BTD, BLVRA, SCT, CIRH1A, MUC16
16	hemochromatosis	32.2	REN, SERPINA1, BMP6, B2M, CFTR, ATP7B
17	thrombocytopenia	32.0	SELE, SELP, SERPINC1, SERPINE1, BMP6, RAF1
18	sepsis	31.9	PDE4A, RETN, RBP4, SELE, SELP, SERPINC1
19	pancreatitis	31.8	NCALD, PDE4A, REG1A, REN, RETN, CNR1
20	alcohol dependence	31.8	REN, CNR1, SERPINA7, LEP, MTHFR, AVP
21	alcoholic hepatitis	31.4	LBP, IL1A, IL8, APOA1, GPT, ICAM1
22	portal vein thrombosis	31.4	REN, SELP, SERPINC1, SERPINE1, MTHFR, APOH
23	protein-energy malnutrition	31.4	RBP4, LEP, CFTR, CD79A, GPT, IGFBP1
24	congestive heart failure	31.3	REN, UTS2, MUC16, XDH, FN1, MIP
25	hepatorenal syndrome	31.1	REN, NAGLU, IL18, AQP1, AQP2, F2
26	retinol binding protein	31.1	RETN, RBP4, VIM, NAGLU, NAMPT, LEP
27	iron overload	31.0	RBP4, SELP, SERPINA7, NAGLU, BMP6, XDH
28	disseminated intravascular coagulation	30.8	SELE, SERPINC1, SERPINF2, SERPINE1, NAGLU, VEGFA
29	hypogonadism	30.7	PDE4A, RETN, GC, SERPINC1, SERPINA6, SERPINE1
30	cholangitis	30.7	BIRC5, SCT, CFTR, CD79A, CDKN2A, MMP1
31	hypertrophic cardiomyopathy	30.6	REN, RETN, SELP, RAF1, BIRC5, MUC16
32	insulin resistance	30.4	REN, RETN, CNR1, GCK, GCG, RBP4
33	thrombosis	30.4	REN, RETN, SELE, SELP, SERPINC1, SERPINF2
34	arthritis	30.3	SERPINA1, VIP, IL17A, IL1A, IL1B, IL6
35	glycogen storage disease	30.3	GCG, BTD, RBP4, NAGLU, BMP6, MTHFR
36	acute pancreatitis	30.2	REG1A, RETN, CNR1, SELE, SELP, SERPINC1
37	hemolytic anemia	30.2	LCAT, APOH, IFNA2, F3, HP, CR1
38	cholelithiasis	30.2	VIP, CD79A, GUSB, INS, IL1R1, IL4
39	hypercalcemia	30.2	GC, VIM, BMP6, BGLAP, SCT, B2M
40	acute liver failure	30.1	GC, GPT, F2, ALB, TSPO, THPO
41	galactosemia	30.1	SERPINA1, MIP, AQP2, GPT, IGFBP2, F3
42	primary hyperparathyroidism	30.1	GC, SELE, SERPINE1, BGLAP, LEP, B2M
43	hypersplenism	30.0	IL11, F2, ALB, EVL, TLR4, THPO
44	venous thrombosis	29.9	SELP, SERPINC1, SERPINF2, SERPINE1, MTHFR, MTR
45	hepatitis a	29.9	SERPINC1, BCR, LEP, B2M, CD79A, CD4
46	nonalcoholic steatohepatitis	29.9	RETN, SERPINE1, BMP6, LEP, LEPR, MTHFR
47	cholestasis	29.6	CNR1, GCG, RBP4, SERPINC1, SERPINA1, VEGFA
48	thromboembolism	29.5	SELP, SERPINC1, SERPINF2, SERPINE1, SERPINA3, MTHFR
49	diabetes mellitus	29.5	PDE4A, REG1A, REN, RETN, CNR1, GCK
50	esophagitis	29.3	PDE4A, REG1A, CNR1, GCG, RB1, RBP4

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 bumetanide, ethacrynate sodium, ethacrynic acid, furosemide, milk thistle, torsemide

Cell-based therapeutics:

Peripheral blood/mobilized hematopoietic stem cells, PMIDs: 20587151

MalaCards organs/tissues related to liver cirrhosis:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Bone -> Bone Marrow -> Hematopoietic Stem Cells	Potential therapeutic candidate
2	Liver -> Sinusoids -> Hepatic Stellate Cells	Potential therapeutic candidate, affected by disease
3	Liver -> Liver Lobule -> Hepatocytes	Potential therapeutic candidate, affected by disease

MGI Mouse Phenotypes related to liver cirrhosis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	11.8	REN, GCK, BTD, SELP, SERPINA6, NAGLU
2	hematopoietic system phenotype	MP:0005397	11.7	SERPINB2, SERPINB1, BCL2, LGALS3, ATP7B, MPL
3	nervous system phenotype	MP:0003631	11.7	PDE4A, REN, CNR1, RB1, SELP, SERPINC1
4	homeostasis/metabolism phenotype	MP:0005376	11.6	REG1A, REN, RETN, CNR1, GCK, GCG
5	mortality/aging	MP:0010768	11.5	REN, CNR1, GCK, GCG, RB1, SELE
6	respiratory system phenotype	MP:0005388	11.4	SELP, SERPINB1, LEPR, CFTR, CD14, ITGB3
7	endocrine/exocrine gland phenotype	MP:0005379	11.3	REG1A, VIPR1, XDH, GUSB, IL2, AQP1
8	growth/size phenotype	MP:0005378	11.2	REN, CNR1, GCK, GCG, BTD, RB1
9	behavior/neurological phenotype	MP:0005386	10.9	REN, CNR1, BTD, RB1, SELE, SELP
10	liver/biliary system phenotype	MP:0005370	10.8	RETN, GCK, SERPINC1, SERPINA6, VEGFA, BHMT
11	immune system phenotype	MP:0005387	10.7	PDE4A, REN, SELP, SERPINA6, SERPINB2, SERPINB1
12	craniofacial phenotype	MP:0005382	10.7	NAGLU, CFTR, GUSB, IL17A, ILK, MARCKS
13	embryogenesis phenotype	MP:0005380	10.4	SERPINC1, VIM, RAF1, BIRC5, XRCC1, MPL
14	normal phenotype	MP:0002873	10.2	REN, RBP4, SELE, VIP, VEGFA, KDR
15	adipose tissue phenotype	MP:0005375	10.0	RETN, CNR1, RB1, SERPINE1, BCL2, LEP
16	other phenotype	MP:0005395	9.8	CNR1, KDR, LEPR, LAMC2, ATP7B, CDKN2A
17	pigmentation phenotype	MP:0001186	9.5	BTD, RB1, SERPINC1, NAGLU, BCL2, LEP
18	hearing/vestibular/ear phenotype	MP:0005377	9.5	RB1, NAGLU, BCL2, BCR, MTAP, LAMC2
19	integument phenotype	MP:0010771	9.5	CNR1, BTD, RB1, SELP, RAF1, BCL2
20	limbs/digits/tail phenotype	MP:0005371	9.2	RB1, VEGFA, LEP, MTHFR, LAMC2, MMP13
21	no phenotypic analysis	MP:0003012	9.1	CNR1, RB1, SERPINA6, VEGFA, VCAM1, LEPR
22	reproductive system phenotype	MP:0005389	9.0	REG1A, REN, RBP4, VIP, VEGFA, BCHE
23	digestive/alimentary phenotype	MP:0005381	8.9	GCG, RB1, VIPR1, VEGFA, BCL2, BCR
24	cardiovascular system phenotype	MP:0005385	8.8	PDE4A, REN, RB1, RBP4, SELE, SELP
25	skeleton phenotype	MP:0005390	8.6	CNR1, GC, RB1, NAGLU, VEGFA, BMP6
26	muscle phenotype	MP:0005369	8.1	REN, BTD, RB1, RBP4, SERPINB2, VIM
27	tumorigenesis	MP:0002006	7.8	RB1, SERPINE1, BHMT, BCL2, LEP, LEPR
28	cellular phenotype	MP:0005384	7.6	CNR1, RB1, RBP4, SELE, SELP, SERPINB1
29	vision/eye phenotype	MP:0005391	6.7	BTD, RB1, RBP4, SELE, SELP, SERPINC1

Articles related to liver cirrhosis:

(show top 50)    (show all 537)

id	Title	Authors	Year	Affiliating Genes
1	IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: role in the course of chronic viral hepatitis and the de velopment of HCC. (21146242)	Fabris C.... Toniutto P.	2011	IL28B
2	Plasma levels of PBEF/Nampt/visfatin are decreased in patients with liver cirrhosis. (19074645)	de Boer J.F.... Tietge U.J.	2009	NAMPT
3	Repeated administration of recombinant human serum albumin caused no serious allergic reactions in patients with liver cirrhosis: a multicenter clinical study. (18600391)	Kasahara A.... Kumada H.	2008	ALB
4	A comparative pharmacokinetic study of recombinant human serum albumin with plasma-derived human serum albumin in patients with liver cirrhosis. (18199895)	Ohnishi K.... Ueshima T.	2008	ALB
5	ILK overexpression in human hepatocellular carcinoma and liver cirrhosis correlates with activation of Akt. (19020711)	Peroukides S.... Papadaki H.	2008	AKT1, ILK
6	Manganese superoxide dismutase activity and incidence of hepatocellular carcinoma in patients with Child-Pugh class A liver cirrhosis: a 7-year follow-up study. (17617122)	Clemente C.... Russo F.	2007	SOD2
7	Nerve growth factor involvement in liver cirrhosis and hepatocellular carcinoma. (17854142)	Rasi G.... Puoti C.	2007	NGF
8	Elevation of endoglin (CD105) concentrations in serum of patients with liver cirrhosis and carcinoma. (17700260)	Yagmur E.... Gressner A.M.	2007	ENG, AFP
9	Incidence and factors predictive of acute renal failure in patients with advanced liver cirrhosis. (16429839)	Wu C.C.... Lu K.C.	2006	GGT1
10	Polymorphisms of glutathione S-transferase M1, T1, and P1 in patients with HBV-related liver cirrhosis, chronic hepatitis, and normal carriers. (16316639)	Mohammadzadeh Ghobadloo S.... Zali M.R.	2006	GSTP1, GSTT1, GSTM1
11	Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF. (16958060)	Bueno M.... Armendariz-Borunda J.	2006	HGF
12	Genetic polymorphism of alcohol dehydrogenase 3 in alcohol liver cirrhosis and in alcohol chronic pancreatitis. (16239350)	Cichoz-Lach H.... Wojcierowski J.	2006	ADH1C
13	Expression of augmenter of liver regeneration (ALR) in human liver cirrhosis and carcinoma. (15982324)	Thasler W.E.... Weiss T.S.	2005	GFER
14	Contribution of defects in glucose uptake to carbohydrate intolerance in liver cirrhosis: assessment during physiological glucose and insulin concentrations. (15637182)	Nielsen M.F.... Vilstrup H.	2005	INS
15	Correlation of nitric oxide and atrial natriuretic peptide changes with altered cGMP homeostasis in liver cirrhosis. (15998430)	Montoliu C.... Felipo V.	2005	NPPA
16	Effects of amino acid solution and recombinant human growth hormone on growth hormone/insulin like growth factor-1 axis in rats with liver cirrhosis (16008955)	Liang L.J.... Hu W.J.	2005	IGFBP3, GH1
17	Observation on short-term therapeutic effect of zhenggan recipe in treating liver cirrhosis with alpha-feto-protein (16313121)	Yang D.G.... He Q.	2005	AFP
18	High ascitic fluid leptin levels in patients with decompensated liver cirrhosis and sterile ascites: relationship with TNF-alpha levels. (15104370)	Giannini E.... Testa R.	2004	TNF, LEP
19	Implication of inflammation-related cytokines in the natural history of liver cirrhosis. (15482340)	GirA^n-GonzA!lez J.A.... MartA-n-Herrera L.	2004	IL6
20	Increased serum soluble tumor necrosis factor receptor levels are associated with insulin resistance in liver cirrhosis. (15254888)	Lin S.Y.... Sheu W.H.	2004	INS
21	Procalcitonin as an indicator of infection in patients with liver cirrhosis (15077592)	HusovA! L.... Lata J.	2004	TNF, IL6, IL8
22	Distribution of constitutive (COX-1) and inducible (COX-2) cyclooxygenase in postviral human liver cirrhosis: a possible role for COX-2 in the pathogenesis of liver cirrhosis. (15047734)	Mohammed N.A.... El-Aleem S.A.	2004	PTGS2
23	The correlation of Child-Pugh score, PGA index and M ELD score in the patient with liver cirrhosis and hepatocellular carcinoma acco rding to the cause of alcohol and hepatitis B virus (12824750)	Mun B.S.... Lee S.O.	2003	F2, APOA1
24	Albumin differentiation by isoelectric focusing in p atients with liver cirrhosis (12889356)	Zueva E.B.... Usmanov R.I.	2003	ALB
25	Elevation of serum and ascites cancer antigen 125 levels in patients with liver cirrhosis. (14535990)	Xiao W.B.... Liu Y.L.	2003	MUC16
26	Polymorphism in codons 10 and 25 of the transforming growth factor-beta1 gene in Korean population and in patients with liver cirrhosis and hepatocellular carcinoma (14532743)	Kwon O.S.... Lee C.H.	2003	TGFB1
27	A prospective randomized controlled clinical trial comparing the effects of somatostatin and vasopressin for control of acute variceal bleeding in the patients with liver cirrhosis. (14619385)	Lee H.Y.... Kim N.J.	2003	SST
28	Studies on the mechanism of elevation of serum PIVKA-II levels in alcoholic liver cirrhosis (11985059)	Sakizono K.... Kasakura S.	2002	GPT
29	Intestinal first pass metabolism of midazolam in liver cirrhosis --effect of grapefruit juice. (12207630)	Andersen V.... Larsen S.	2002	CYP3A4
30	Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis. (11549587)	Lu M.... Tan E.M.	2001	SQSTM1
31	Severe hemolysis and SIADH-like symptoms induced by vincristine in an ALL patient with liver cirrhosis (11193445)	Nishihori Y.... Niitsu Y.	2000	SLC17A5
32	Analysis of biochemical and virological efficacy of human lymphoblastoid interferon (IFN) in patients with compensated type C liver cirrhosis: comparative study between increase in individual IFN dose and prolonging of treatment period, using a multicenter randomized controlled trial. (10749335)	Shinzawa H.... Ichida H.	2000	IFNA1
33	Vitamin E status in patients with liver cirrhosis: normal or deficient? (9920150)	Look M.P.... Sauerbruch T.	1999	TTR
34	Albumin substitution improves urinary sodium excretio n and diuresis in patients with liver cirrhosis and refractory ascites. (10604590)	Schindler C.... Ramadori G.	1999	ALB
35	Different protein-binding patterns in the P3 promoter region of the human insulin-like growth factor II gene in the human liver cirrhosis and hepatocellular carcinoma tissues. (9610618)	Seo J.H.... Park B.C.	1998	IGF2
36	Abnormal gastric motility in liver cirrhosis: roles of secretin. (9824124)	Usami A.... Onji M.	1998	MLN, SCT
37	Lysosomal cathepsins B and L and Stefin A blood levels in patients with hepatocellular carcinoma and/or liver cirrhosis: potential clinical implications. (8978598)	Leto G.... Gebbia N.	1997	CTSL1, CSTA
38	Liver cirrhosis: epidemiological aspects in Italy. (9108615)	De Bac C.... Taliani G.	1997	GPT
39	Nutritional and prognostic significance of insulin-like growth factor 1 in patients with liver cirrhosis. (9131676)	Caregaro L.... Gatta A.	1997	IGF1
40	Serum amino acid changes in rats with thioacetamide-induced liver cirrhosis. (8571392)	Fontana L.... Gil A.	1996	GLUD1, GPT
41	Prognostic indicators in patients with liver cirrhosis admitted to an intensive care unit (8763065)	Castera L.... LAcvy V.G.	1996	F2
42	Modulation of hemostatic balance with antithrombin III replacement therapy in a case of liver cirrhosis associated with recurrent venous thrombosis. (7627635)	Carmassi F.... Carrai M.	1995	SERPINC1
43	A case of glycogen storage disease type III (glycogen debranching enzyme deficiency) with liver cirrhosis and hypertrophic cardiomyopathy. (8553356)	Kobayashi A.... Fukase M.	1995	AGL
44	Blood chemistry, hematology of patients with liver cirrhosis (8114309)	Kakehashi R.... Suzuki S.	1994	ALB, GPT
45	Plasma serine protease inhibitors in patients with liver cirrhosis (8067185)	Piatkowska M.... Opoka J.	1994	SERPINC1, SERPINF2
46	Plasma endothelin-1 concentrations are elevated in acute hepatitis and liver cirrhosis but not in chronic hepatitis. (8224617)	Uchida Y.... Watanabe M.	1993	EDN1
47	Plasma prekallikrein levels in patients with hepatocellular carcinoma and liver cirrhosis: a pilot study. (8250496)	Ciechanowicz A.... Marzecka J.	1993	KLKB1
48	Effect of intravenous polyunsaturated phosphatidylcholine infusion on insulin receptor processing and lipid composition of erythrocytes in patients with liver cirrhosis. (1478248)	Cantafora A.... Peterson S.W.	1992	INSR
49	Glucagon-independent renal hyperaemia and hyperfiltration after an oral protein load in Child A liver cirrhosis. (1559540)	De Santo N.G.... Alfieri R.	1992	REN
50	Urinary N-acetyl-beta-D-glucosaminidase activity in liver cirrhosis with renal impairment (2027251)	Amakasu H.... Goto Y.	1991	NAGLU

Genes related to liver cirrhosis according to GeneCards:

(show top 50)    (show all 335)

id	Symbol	Description	Score	GeneCards Section Context
1	PLIN2	perilipin 2	11.1	Summaries
2	ASGR2	asialoglycoprotein receptor 2	11.0	Publications
3	AHSG	alpha-2-HS-glycoprotein	11.0	Publications
4	ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	11.0	Publications
5	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	11.0	Publications
6	ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	11.0	Publications
7	TAT	tyrosine aminotransferase	11.0	Publications
8	GHRH	growth hormone releasing hormone	11.0	Publications
9	CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	11.0	Publications
10	CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	11.0	Publications
11	ALB	albumin	11.0	Publications
12	ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	11.0	Publications
13	LSL	Leptin, serum levels of	11.0	Publications
14	TTR	transthyretin	11.0	Publications
15	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
16	F2	coagulation factor II (thrombin)	11.0	Publications
17	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
18	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
19	IFNA1	interferon, alpha 1	11.0	Publications
20	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	11.0	Publications
21	INSR	insulin receptor	11.0	Publications
22	TGFB1	transforming growth factor, beta 1	11.0	Publications
23	ADH4	alcohol dehydrogenase 4 (class II), pi polypeptide	11.0	Publications
24	THPO	thrombopoietin	11.0	Publications
25	MAGEA4	melanoma antigen family A, 4	11.0	Publications
26	BHMT	betaine--homocysteine S-methyltransferase	11.0	Publications
27	ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide	11.0
28	ESD	esterase D	11.0	Publications
29	MGAT3	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	11.0	Publications
30	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	11.0	Publications
31	TALDO1	transaldolase 1	11.0	Publications
32	ALPI	alkaline phosphatase, intestinal	11.0	Publications
33	AFP	alpha-fetoprotein	11.0	Publications
34	MAT1A	methionine adenosyltransferase I, alpha	11.0	Publications
35	REG1A	regenerating islet-derived 1 alpha	11.0
36	PTMA	prothymosin, alpha	11.0	Publications
37	PGD	phosphogluconate dehydrogenase	11.0	Publications
38	AVP	arginine vasopressin	11.0	Publications
39	MLN	motilin	11.0	Publications
40	ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	11.0
41	ADH7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	11.0
42	KLKB1	kallikrein B, plasma (Fletcher factor) 1	11.0	Publications
43	UTS2	urotensin 2	11.0	Publications
44	CTH	cystathionase (cystathionine gamma-lyase)	11.0	Publications
45	NEU1	sialidase 1 (lysosomal sialidase)	11.0	Publications
46	MAGEA1	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	11.0
47	GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	11.0	Publications
48	PNOC	prepronociceptin	11.0
49	GLS	glutaminase	11.0	Publications
50	MPL	myeloproliferative leukemia virus oncogene	11.0	Publications

Pathways related to liver cirrhosis according to GeneDecks:

(show top 50)    (show all 121)

id	Pathway	Score	Top Affiliating Genes
1	Metabolic pathways20	13.0	GCK, BTD, NAGLU, NAT2, BHMT, UGT1A7
2	mTOR Pathway36	11.6	BMP6, UTS2, IRS1, INS, INSR, FGF2
3	NF-KappaB (p50-p65) Pathway36	11.2	BMP6, UTS2, KDR, FLT1, FGF2, IL1A
4	NF-KappaB Family Pathway36	11.2	BMP6, UTS2, KDR, FLT1, FGF2, IL1A
5	Glioma Invasiveness36	11.1	BMP6, UTS2, ITGAM, FGF2, GH1, GHRH
6	Paxillin Interactions36	11.0	UTS2, KDR, ITGAM, ITGB3, FLT1, INSR
7	CREB Pathway36	10.9	BMP6, UTS2, KDR, IL2, IL2RA, IGF2
8	Activation of PKA through GPCR36	10.9	GCG, BMP6, RAF1, UTS2, KDR, FLT1
9	Amoebiasis20	10.9	SERPINB2, SERPINB1, LAMC2, CD14, ITGAM, FN1
10	eNOS Signaling36	10.8	BMP6, UTS2, INSR, IL2, AQP1, AQP2
11	eIF2 Pathway36	10.8	BMP6, RAF1, UTS2, INS, INSR, FGF2
12	Hematopoietic cell lineage20	10.8	CD36, CD8A, CD14, CD4, CD34, ITGAM
13	Nuclear Receptor Activation by Vitamin-A36	10.7	BMP6, UTS2, KDR, FLT1, FGF2, IL2
14	Bacterial infections in CF airways41	10.7	LBP, CFTR, IL1R1, CTSL1, TLR2
15	DHA Signaling36	10.7	BMP6, UTS2, KDR, BCL2, FLT1, FGF2
16	PPAR Pathway36	10.6	RAF1, UTS2, ITGAM, ITGB3, FLT1, FGF2
17	Nanog in Mammalian ESC Pluripotency36	10.6	BMP6, RAF1, UTS2, KDR, FLT1, INSR
18	p70S6K Signaling36	10.6	BMP6, RAF1, UTS2, KDR, IRS1, FLT1
19	ERK5 Signaling36	10.6	BMP6, UTS2, KDR, FOS, FLT1, IL2
20	GPCR Pathway36	10.5	BMP6, RAF1, UTS2, KDR, JUN, FOS
21	Phospholipase-C Pathway36	10.4	BMP6, RAF1, UTS2, KDR, LAMC2, CD79A
22	NFAT in Immune Response36	10.3	BMP6, UTS2, KDR, JUN, CD79A, CD4
23	Malaria20	10.3	SELE, SELP, VCAM1, CD36, IL10, IL18
24	Ras Pathway36	10.2	RAF1, UTS2, KDR, JUN, ITGAM, ITGB3
25	ILK Signaling36	10.2	VIM, UTS2, KDR, LAMC2, JUN, CDH1
26	ERK Signaling36	10.1	BMP6, RAF1, UTS2, LAMC2, ITGAM, FN1
27	PTEN Pathway36	10.1	UTS2, KDR, LAMC2, ITGAM, FN1, FLT1
28	Telomerase Components in Cell Signaling36	10.0	RB1, BMP6, UTS2, KDR, FLT1, FGF2
29	PAK Pathway36	9.9	BMP6, UTS2, KDR, BCL2, FLT1, FGF2
30	p53 Mediated Apoptosis36	9.9	BMP6, UTS2, KDR, BCL2, FLT1, FGF2
31	MAPK Signaling36	9.9	BMP6, RAF1, UTS2, KDR, BCL2, LAMC2
32	MIF Mediated Glucocorticoid Regulation36	9.9	BMP6, BCL2, CD14, IL10, IL11, IL18
33	PEDF Induced Signaling36	9.8	BMP6, RAF1, BCL2, FOS, IL10, IL11
34	Estrogen Pathway36	9.8	BMP6, RAF1, UTS2, KDR, BCL2, JUN
35	Endothelin-1 Signaling Pathway36	9.7	BMP6, RAF1, FLT1, INSR, IL10, IL11
36	Cellular Apoptosis Pathway36	9.7	BMP6, UTS2, KDR, BCL2, CDKN2A, FLT1
37	Cell adhesion ECM remodeling10	9.7	SERPINE1, LAMC2, MMP1, MMP13, MMP2, MMP7
38	JNK Pathway36	9.7	BMP6, RAF1, UTS2, KDR, BCL2, JUN
39	Rheumatoid arthritis20	9.6	VEGFA, JUN, MMP1, FOS, FLT1, IL11
40	Cell adhesion_ECM remodeling41	9.5	SERPINE1, LAMC2, MMP1, MMP13, MMP2, MMP7
41	p38 Signaling36	9.5	BMP6, UTS2, KDR, BCL2, CD4, FLT1
42	Rho Family GTPases36	9.5	VIM, BMP6, RAF1, UTS2, KDR, BCL2
43	MIF Regulation of Innate Immune Cells36	9.4	BMP6, BCL2, JUN, CD14, FOS, IL10
44	Cytokine-cytokine receptor interaction20	9.4	VEGFA, KDR, LEP, LEPR, MPL, FLT1
45	Chagas disease (American trypanosomiasis)20	9.3	SERPINE1, JUN, FOS, IL10, IL1B, IL2
46	Tuberculosis20	9.3	RAF1, BCL2, LBP, CD14, ITGAM, IL10
47	Molecular Mechanisms of Cancer36	9.1	RB1, BMP6, RAF1, UTS2, KDR, BCL2
48	Pancreatic Adenocarcinoma36	9.0	RB1, BMP6, RAF1, UTS2, BIRC5, KDR
49	Leishmaniasis20	8.7	JUN, ITGAM, FOS, IL10, IL1A, IL1B
50	Pathways in cancer20	8.1	RB1, VEGFA, BIRC5, BCL2, BCR, JUN

Compounds related to liver cirrhosis according to GeneDecks:

(show top 50)    (show all 539)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	16.5	NCALD, PDE4A, REG1A, REN, RETN, CNR1
2	cholesterol32 9 18 9	16.2	REN, RETN, GCK, GC, RB1, RBP4
3	atp32	12.6	PDE4A, GCK, RB1, BIRC5, BCR, SCT
4	hydrogen32 18	13.1	PDE4A, GCK, SERPINB2, BCR, SCT, MTR
5	nadph32 18	13.0	GCK, UTS2, BLVRA, XRCC1, ASS1, GLUD1
6	methionine32	11.9	SERPINB2, SERPINA1, SERPINA3, VIM, LCAT, MTAP
7	malondialdehyde32	11.9	NAGLU, XDH, GSTM1, GSTT1, FGA, IL2RA
8	iron32 18	12.9	RBP4, SERPINA7, SERPINA1, SERPINA3, VIM, NAGLU
9	nitric oxide32 9 18 9	14.8	PDE4A, REN, RETN, GCK, RB1, SELE
10	phenobarbital32 9 9	13.8	SERPINA7, GUSB, GSTM1, APOA1, GPT, IGF2
11	ascorbic acid32 18	12.8	RBP4, SERPINB2, RAF1, BGLAP, LCAT, XRCC1
12	androstenedione32 18	12.7	REN, RBP4, SERPINA6, LEP, LEPR, INS
13	superoxide32 18	12.7	PDE4A, GC, RB1, SERPINB2, SERPINA3, SERPINB1
14	vitamin b1232	11.6	SERPINA3, BHMT, MTHFR, MTR, B2M, CD79A
15	dopamine32 9 18 9	14.4	PDE4A, REN, GCG, RBP4, SELE, SERPINA3
16	histidine32	11.3	PDE4A, SERPINA7, SCT, MTR, XRCC1, AVP
17	phosphorus32	11.3	RBP4, NAGLU, B2M, GPT, ALPP, CASR
18	mannose 6-phosphate32 18	12.3	REN, GCK, NAGLU, BMP6, JUN, GZMB
19	norepinephrine32 9 18 9	14.3	PDE4A, REN, RETN, CNR1, GCG, SELE
20	haloperidol32 34 9 9	14.2	REN, VIP, MMP1, FOS, IL1R1, AQP2
21	zidovudine32 9 9	13.2	UGT1A7, B2M, CD4, GUSB, IL10, IL2
22	rosiglitazone32 9 18 9	14.0	RETN, RBP4, SELE, SERPINE1, NAMPT, VCAM1
23	deoxypyridinoline32	11.0	BGLAP, CD36, IL11, IL6R, IGFBP1, IGFBP2
24	ticlopidine32 9 9	12.9	SELP, SERPINC1, FGA, APOH, F3, CYP1A1
25	leupeptin32	10.9	VIP, CD4, IGFBP3, IDE, HSPA5, CTSD
26	agar32	10.8	RB1, VIM, BIRC5, MTAP, CDKN2A, CD34
27	levodopa32 9 9	12.7	CNR1, MAT1A, AKR1A1, GH1, GHR, GHRH
28	glutaraldehyde32	10.7	BCHE, CD79A, CD36, INSR, ALDH9A1, GLUD1
29	nitrate32	10.6	B2M, CD14, IL1R1, IL2RA, FASLG, ALDH2
30	calcitriol32 42 9 18 9	14.6	REN, GC, RB1, BMP6, BGLAP, LBP
31	pge232	10.6	PDE4A, REN, SELE, SERPINB2, VIP, VCAM1
32	caffeine32 34 9 18 9	14.5	PDE4A, VIP, NAT2, BMP6, BGLAP, XDH
33	carvedilol32 34 9 9	13.5	REN, SELE, VEGFA, VCAM1, XDH, CYP1A1
34	theophylline32 9 18 9	13.4	PDE4A, SELP, RAF1, XDH, B2M, CD79A
35	pegvisomant32 9 9	12.3	BCHE, MBL2, IGFBP1, IGF2, IGFBP3, IGF1
36	prednisolone32 9 9	12.1	SERPINA6, VIP, VCAM1, BMP6, BGLAP, MUC16
37	ramipril32 9 9	12.1	REN, SERPINE1, BCHE, CD79A, INS, ALB
38	groalpha32	10.1	SELE, VCAM1, MMP13, IL10, IL17A, IL18
39	lipoteichoic acid32	10.0	SELE, LBP, CD14, IL10, IL18, IL1B
40	dihydrotestosterone32 9 18 9	13.0	SERPINA6, SERPINE1, VIM, VIP, BMP6, BGLAP
41	vitamin d32	10.0	GC, SERPINE1, VIM, NAGLU, BMP6, BGLAP
42	prostaglandin f2alpha32	9.9	PDE4A, SERPINE1, VIP, RAF1, MMP1, IL1A
43	mifepristone32 42 9 9	12.9	SERPINA6, BIRC5, JUN, MMP1, IRS1, IL1B
44	c2ceramide32	9.6	JUN, IRS1, IL1B, AKT1, GH1, TNF
45	gsno32	9.5	SELP, XDH, CFTR, JUN, FN1, INSR
46	cytarabine32 34 9 9	12.4	RB1, VIM, BCL2, BCR, JUN, CD36
47	phorbol32	9.1	RBP4, SERPINB2, RAF1, JUN, CD4, ITGAM
48	il 1032	9.1	BMP6, LBP, CD8A, IL10, IL18, IL1A
49	azathioprine32 34 9 9	11.8	VIM, BGLAP, MTHFR, XDH, CD79A, CDKN2A
50	tamoxifen32 34 9 9	11.0	PDE4A, SELE, SERPINC1, SERPINA7, SERPINA6, VIM

Cellular components related to liver cirrhosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	11.7	IGF2, GHRL, TNFRSF11B, SST, CTGF, CTSD
2	platelet alpha granule lumen	GO:031093	10.9	F8, ALB, PPBP, PLG, PDGFA, PDGFB
3	extracellular space	GO:005615	10.9	EDN3, SOD1, CSF2, CST3, NPPB, NPY
4	cell surface	GO:009986	10.9	TIMP2, TGFA, TGFB1, TGFB3, DPP4, PVR
5	plasma membrane	GO:005886	10.4	ITGB3, FAS, AOC3, ANGPT2, MAGEA1, MARCKS
6	cytosol	GO:005829	10.3	ODC1, CTGF, CTH, CTNNB1, PPARG, PLCG1
7	external side of plasma membrane	GO:009897	9.5	CD8A, CD4, CD34, FGA, IL17A, IL4

Biological processes related to liver cirrhosis according to GeneDecks:

(show all 35)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	13.8	ADH1B, ADH4, ADH7, ADA, ADH1A, ADH1C
2	xenobiotic metabolic process	GO:006805	11.8	CYP2A6, CYP2C19, CYP2E1, ADH1B, ADH4, ADH7
3	positive regulation of MAPK cascade	GO:043410	11.5	KDR, LEP, CD36, ADRB3, FLT1, INS
4	platelet activation	GO:030168	11.5	IL11, IL6, APOA1, GP1BA, IGF1, F8
5	positive regulation of NF-kappaB transcription factor activity	GO:051092	11.3	NFKBIA, KRAS, AGT, TLR2, TLR4, TGFB1
6	positive regulation of cell proliferation	GO:008284	11.3	FGF2, PDGFB, KRAS, EDN1, EDN3, EDNRA
7	platelet degranulation	GO:002576	11.2	ITGB3, FN1, FGA, APOA1, IGF1, F8
8	positive regulation of mitosis	GO:045840	11.2	TGFA, EDN3, EDN1, PDGFB, TNF, IGF1
9	acute-phase response	GO:006953	11.2	SERPINA1, SERPINA3, LBP, FN1, ASS1, INS
10	aging	GO:007568	11.2	EDNRA, AGT, TSPO, TIMP1, TGFB1, TGFB3
11	fibrinolysis	GO:042730	11.0	PROS1, KLKB1, PLG, PLAUR, PLAU, PLAT
12	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.7	GH1, PDGFA, PDGFB, AGT, HGF, CAT
13	positive regulation of protein phosphorylation	GO:001934	10.7	TGFB1, EDNRA, KRAS, CTGF, TNF, AKT1
14	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.6	IL6, IL6R, IGF2, IGF1, GH1, GHR
15	response to estradiol stimulus	GO:032355	10.5	GHR, PTGS2, CTGF, CTNNB1, NOS3, PDGFB
16	response to lipopolysaccharide	GO:032496	10.4	CNR1, SELE, SELP, THPO, SOCS1, ADM
17	positive regulation of MAP kinase activity	GO:043406	10.4	TGFB1, EGFR, EDN3, EDN1, KRAS, PDGFB
18	positive regulation of cell division	GO:051781	10.3	PDGFA, PDGFB, TGFA, TGFB1, TGFB3, PPBP
19	female pregnancy	GO:007565	10.3	HFE, TGFB1, TGFB3, PRL, NPPA, ADM
20	cell surface receptor signaling pathway	GO:007166	10.2	F2, EVL, SST, EDN1, EDN3, EDNRB
21	positive regulation of angiogenesis	GO:045766	10.2	IL1B, AQP1, ANGPT2, F3, PLCG1, NOS3
22	regulation of blood pressure	GO:008217	10.2	ACE, SOD1, SOD2, NPPA, NPPB, EDNRB
23	response to ethanol	GO:045471	10.1	NOS3, ACTC1, TLR4, SOD1, SLC2A4, ADH7
24	positive regulation of nitric oxide biosynthetic process	GO:045429	10.1	PTGS2, EDN1, EGFR, TLR2, TLR4, TNF
25	defense response to Gram-negative bacterium	GO:050829	10.0	TLR4, NOS2, IL6R, IL6, MMP7, CD4
26	anti-apoptosis	GO:006916	9.9	GSTP1, IL10, IL1A, IL1B, IL2, FAS
27	blood coagulation	GO:007596	9.9	MPL, CD36, ITGAM, ITGB3, MMP1, FN1
28	negative regulation of cell proliferation	GO:008285	9.8	CTH, CTNNB1, PLG, NOS3, WT1, AGT
29	response to glucocorticoid stimulus	GO:051384	9.7	ALPL, HSD11B2, GHR, TNF, PTGS2, PLAT
30	response to hypoxia	GO:001666	9.7	CXCR4, NPPB, ADM, ADA, ADIPOQ, CXCL12
31	cellular response to lipopolysaccharide	GO:071222	9.5	IFNG, ICAM1, NOS2, TSPO, TLR4, IL8
32	inflammatory response	GO:006954	9.4	CRP, PTGS2, TNF, AKT1, IFNA2, NGF
33	response to organic cyclic compound	GO:014070	9.4	CTGF, PLIN2, NOS3, PDGFB, TAT, NPPB
34	negative regulation of apoptotic process	GO:043066	9.1	TP53, TNF, PLAUR, WT1, KRT18, EDNRA
35	response to drug	GO:042493	8.3	ASS1, IL10, IL1RN, IL4, AQP1, FAS

Molecular functions related to liver cirrhosis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:005179	11.4	GAST, INS, MLN, LEP, SCT, UTS2
2	eukaryotic cell surface binding	GO:043499	10.9	ADIPOQ, TGFB1, PDGFB, PDGFA, MBL2, APOH
3	receptor binding	GO:005102	10.7	CXADR, DPP4, EDN3, NOS2, HNF4A, CXCL12
4	growth factor activity	GO:008083	9.9	PDGFA, BMP6, VEGFA, REG1A, LEP, FGF2
5	protease binding	GO:002020	9.9	CSTA, CST3, DPP4, TNF, TP53, F3
6	protein binding	GO:005515	9.4	GGT1, GABRG2, EPO, HGF, ADIPOQ, ADH1A
7	protein homodimerization activity	GO:042803	9.3	SHBG, PDGFB, PDGFA, NFKB1, NOS2, CRP
8	cytokine activity	GO:005125	9.2	IL6, FASLG, IFNA2, IFNG, TNF, TNFRSF11B
9	enzyme binding	GO:019899	8.8	SLPI, TGFB1, EGFR, NFKBIA, NOD2, PLAUR