Aliases & Classifications for Liver Cirrhosis

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Liver Cirrhosis, Aliases & Descriptions:

Name: Liver Cirrhosis 30 9 11 43 60
Cirrhosis 9 43 32 60
 
Cirrhosis of Liver 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


External Ids:

Disease Ontology9 DOID:5082
MeSH33 D008103
NCIt38 C2951

Summaries for Liver Cirrhosis

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MedlinePlus:32 Cirrhosis is scarring of the liver. scar tissue forms because of injury or long-term disease. scar tissue cannot do what healthy liver tissue does - make protein, help fight infections, clean the blood, help digest food and store energy. cirrhosis can lead to easy bruising or bleeding, or nosebleeds swelling of the abdomen or legs extra sensitivity to medicines high blood pressure in the vein entering the liver enlarged veins called varices in the esophagus and stomach. varices can bleed suddenly. kidney failure jaundice severe itching gallstones a small number of people with cirrhosis get liver cancer. your doctor will diagnose cirrhosis with blood tests, imaging tests, or a biopsy. cirrhosis has many causes. in the united states, the most common causes are chronic alcoholism and hepatitis. nothing will make the scar tissue disappear, but treating the cause can keep it from getting worse. if too much scar tissue forms, you may need to consider a liver transplant. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Liver Cirrhosis, also known as cirrhosis, is related to alcoholic liver cirrhosis and portal hypertension. An important gene associated with Liver Cirrhosis is ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide), and among its related pathways are Abacavir Pathway, Pharmacokinetics/Pharmacodynamics and Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics. The drugs bumetanide and ethacrynate sodium and the compounds hepaplastin and antipyrine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related mouse phenotypes are liver/biliary system and reproductive system.

Wikipedia:63 Cirrhosis /s??ro?s?s/ (Greek: ????????; neologism from kirrhos ?????? \"yellowish\" and the suffix -osis... more...

Related Diseases for Liver Cirrhosis

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Diseases related to Liver Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 576)
idRelated DiseaseScoreTop Affiliating Genes
1alcoholic liver cirrhosis32.3GPT, HGF
2portal hypertension31.8ALB, GPT, F2
3hypersplenism31.7F2
4hepatic encephalopathy31.5GPT, ALB, F2
5hepatitis b31.3ASGR2, F2, GPT, ALB, TGFB1
6hepatorenal syndrome31.3F2, ALB
7hepatitis c31.3F2, ASGR2, TGFB1, GPT, CYP2E1
8choledocholithiasis31.2GPT
9thrombocytopenia30.9ALB, F2, GPT
10hepatitis e30.9GPT
11autoimmune hepatitis30.9F2, GPT, ASGR2
12siderosis30.8GPT
13primary biliary cirrhosis30.8ALB, ASGR2, GPT, F2
14dysfibrinogenemia30.8F2
15protein-energy malnutrition30.8ALB, TTR
16alcoholic hepatitis30.7GPT, F2, ALB
17hepatitis a30.7F2
18leukopenia30.7GPT, F2, ALB
19alcohol dependence30.7ADH1B, ADH1C
20pancreatitis30.7ADH1B, ADH1C, TGFB1, CYP2E1, ALDH2, ALB
21viral hepatitis30.6AKR1A1, ADH1B, F2, CYP2A6, GPT
22cholangitis30.6GPT, ALB
23acute liver failure30.6GPT, HGF, F2, ALB
24varicose veins30.5F2, ALB
25cholestasis30.5GPT, F2, ALB
26obstructive jaundice30.5GPT, TTR, AKR1A1
27connective tissue disease30.5F2, TGFB1, ALB
28esophageal cancer30.4ADH1B, CYP2E1, ALDH2
29alcoholic pancreatitis30.3ADH1B, AKR1A1, ALDH2, CYP2E1, ADH1C
30alcohol abuse30.3ALDH2, CYP2E1, GPT, ADH1C, AKR1A1
31liver disease30.3ALB, ALDH2, ADH1B, TGFB1, TTR, F2
32acute pancreatitis30.3ALDH2, GPT, ADH1B, ADH1C
33vasculitis30.3TAT, ALB, F2
34biliary atresia30.2TGFB1, GPT, HGF
35primary hyperoxaluria30.2F2, ALB, TTR
36hepatitis30.2TAT, AHSG, HGF, AKR1A1, ASGR2, NAT2
37pulmonary embolism30.2F2, ALB
38galactosemia30.1F2, GPT, ALB, HGF
39myocardial infarction30.1ALDH2, AKR1A1, TAT, ADH1C
40tuberculosis30.1AKR1A1, NAT2, ALB, TAT, CYP2E1, CYP2A6
41fatty liver disease30.1AHSG, PLIN2, ALDH2, CYP2A6, CYP2E1, GPT
42autonomic neuropathy30.1ALB, TTR
43osteoporosis30.0IGFBP3, TGFB1, AHSG
44lung cancer30.0HGF, TGFB1, CYP2E1, GHRH
45hyperhomocysteinemia29.9TTR, ALB, F2
46proteinuria29.9TTR, TGFB1, ALB
47congenital heart disease29.9ALB, TGFB1, F2
48glomerulosclerosis29.8TGFB1, ALB, HGF
49nasopharyngeal carcinoma29.8CYP2A6, CYP2E1, NAT2
50glucose intolerance29.7ALDH2, GPT, IGFBP3

Graphical network of the top 20 diseases related to Liver Cirrhosis:



Diseases related to liver cirrhosis

Symptoms for Liver Cirrhosis

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Drugs & Therapeutics for Liver Cirrhosis

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Drug clinical trials:

Search ClinicalTrials for Liver Cirrhosis

Search NIH Clinical Center for Liver Cirrhosis

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Liver Cirrhosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Liver Cirrhosis:
Autologous bone marrow-derived mesenchymal stem cells for liver cirhosis
Autologous bone marrow-derived stem cells for treatment of liver cirrhosis
Autologous hematopoietic stem cells for treatment of end-stage chronic liver disease
Bone marrow-derived endothelial progenitor cells for advanced liver cirrhosis
Bone marrow-derived mesenchymal stem cells for treatment of cirrhosis-related refractory ascites
Bone marrow-derived mesenchymal stem cells for treatment of liver cirrhosis
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Mesenchymal stem cells for liver cirrhosis
NU215-01, human umbilical cord mesenchymal stem cells for treatment of liver cirrhosis
Peripheral blood-derived CD34+ or mononuclear cells for liver cirrhosis
StempeucelLC
Umbilical cord-derived mesenchymal stem cells for treatment of liver cirrhosis
Embryonic/Adult Cultured Cells Related to Liver Cirrhosis:
Bone marrow-derived mesenchymal stem cells (family), PMIDs: 21771778, 22121493
Bone marrow-derived mesenchymal stem cells (family), PMID: 22121493
Peripheral blood-derived hematopoietic stem cells, PMID: 20587151
Bone marrow-derived endothelial progenitor cells (family)
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells (family)
Hepatocytes
Bone marrow-derived mesenchymal stem cells (family)
Umbilical cord-derived mesenchymal stem cells
Peripheral blood-derived mesenchymal stem cells (family)
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444
Umbilical cord-derived mesenchymal stem cells (family)

Genetic Tests for Liver Cirrhosis

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Anatomical Context for Liver Cirrhosis

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MalaCards organs/tissues related to Liver Cirrhosis:

31
Liver, Bone, Testes, Kidney, Bone marrow, Endothelial, Heart, Spleen, Monocytes, T cells, Small intestine, Thyroid, Prostate, Brain, Colon, Lung, B cells, Pituitary, Neutrophil, Pancreas, Skin, Tongue

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Liver Cirrhosis:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
3 LiverSinusoidsHepatic Stellate Cells Affected by disease
4 LiverLiver LobuleHepatocytes Affected by disease
5 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
6 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Liver Cirrhosis or affiliated genes

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MGI Mouse Phenotypes related to Liver Cirrhosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.8IGFBP3, ALB, HGF, GHRH, PLIN2, TGFB1
2MP:00053897.4TGFB1, NAT2, AKR1A1, PLIN2, GHRH, F2
3MP:00053787.3GHRH, F2, IGFBP3, AHSG, TGFB1, ADH1C
4MP:00107687.1HGF, F2, CYP2E1, TGFB1, ADH1C, ASGR2
5MP:00053765.1TTR, TGFB1, ADH1C, AHSG, CYP2E1, IGFBP3

Publications for Liver Cirrhosis

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Articles related to Liver Cirrhosis:

(show top 50)    (show all 1392)
idTitleAuthorsYear
1
Alcohol drinking pattern and risk of alcoholic liver cirrhosis: A prospective cohort study. (25634330)
2015
2
Arrhythmia risk in liver cirrhosis. (25866603)
2015
3
Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis. (24424503)
2014
4
Effects of increased von Willebrand factor levels on primary hemostasis in thrombocytopenic patients with liver cirrhosis. (25397410)
2014
5
A novel method for laparoscopic splenectomy in the setting of hypersplenism secondary to liver cirrhosis: ten years' experience. (24867471)
2014
6
Predictive factors that influence the survival rates in liver cirrhosis patients with spontaneous bacterial peritonitis. (23837137)
2013
7
Clinical significance of therapy using branched-chain amino acid granules in patients with liver cirrhosis and hepatocellular carcinoma. (23819582)
2013
8
Immediate effects of different schedules of somatostatin on portal pressure in patients with liver cirrhosis. (23437909)
2013
9
Assessment of Clinical Signs of Liver Cirrhosis Using T1 Mapping on Gd-EOB-DTPA-Enhanced 3T MRI. (24392025)
2013
10
Liver cirrhosis treated by living donor liver transplantation in a patient with AGL mutation c.2607-2610delATTC and c.1672dupA. (23688858)
2013
11
Small bowel abnormalities in patients with compensated liver cirrhosis. (23247799)
2013
12
A case of variceal bleeding from the jejunum in liver cirrhosis. (23593613)
2013
13
Metabonomic profiles discriminate hepatocellular carcinoma from liver cirrhosis by ultraperformance liquid chromatography-mass spectrometry. (22200553)
2012
14
Different patterns of decompensation in patients with alcoholic vs. non-alcoholic liver cirrhosis. (22530565)
2012
15
Psychometric hepatic encephalopathy score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis. (22743001)
2012
16
MR relaxometry of the liver: significant elevation of T1 relaxation time in patients with liver cirrhosis. (22302503)
2012
17
Comparison of hepatic venous pressure gradient and two models of end-stage liver disease for predicting the survival in patients with decompensated liver cirrhosis. (22810110)
2012
18
Obstructive jaundice due to ductus hepaticus communis cyst in patient with liver cirrhosis. (22156359)
2011
19
Induction of blood lymphocyte cytochrome P450 2E1 in early stage alcoholic liver cirrhosis. (20843640)
2011
20
Lack of an association between -308G>A polymorphism of the TNF-I+ gene and liver cirrhosis risk based on a meta-analysis. (22095602)
2011
21
Scrub typhus in patients with liver cirrhosis: a preliminary study. (19624507)
2010
22
Expression of p53 protein in liver and sera of patients with liver fibrosis, liver cirrhosis or hepatocellular carcinoma associated with chronic HCV infection. (19063876)
2009
23
Altered basal and postprandial plasma melatonin, gastrin, ghrelin, leptin and insulin in patients with liver cirrhosis and portal hypertension without and with oral administration of melatonin or tryptophan. (19552764)
2009
24
Clinical and morphological characteristics and some mechanisms of portal gastroduodenopathy in liver cirrhosis]. (20469678)
2009
25
Alcohol abstinence and orthotopic liver transplantation in alcoholic liver cirrhosis. (19460531)
2009
26
UDP-glucuronosyltransferase 1A7 polymorphisms are associated with liver cirrhosis. (18054330)
2008
27
A clinical study of thymosin alpha1 as an auxiliary in treating spontaneous peritonitis in patients with liver cirrhosis]. (17407720)
2007
28
The association of TGF beta1 and AT1R gene polymorphisms with hereditary susceptibility and clinical phenotype of HBV-induced liver cirrhosis]. (17557241)
2007
29
Incidence and factors predictive of acute renal failure in patients with advanced liver cirrhosis. (16429839)
2006
30
Development of cell therapy using autologous bone marrow cells for liver cirrhosis. (16378227)
2005
31
Osteoprotegerin and RANKL in alcoholic liver cirrhosis. (15780054)
2005
32
Elevated circulating adiponectin levels in liver cirrhosis are associated with reduced liver function and altered hepatic hemodynamics. (15010338)
2004
33
Unique hypervascular nodules in alcoholic liver cirrhosis: identical to focal nodular hyperplasia-like nodules? (15582133)
2004
34
Liver cirrhosis due to chronic use of nitrofurantoin]. (14983581)
2004
35
The Bcl-2 and TGF-beta1 levels in patients with chronic hepatitis C, liver cirrhosis and hepatocellular carcinoma. (15724390)
2004
36
Expression of gap junction protein connexin32 in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. (15338370)
2004
37
Progastrin and its products from patients with chronic viral hepatitis and liver cirrhosis. (12825873)
2003
38
Elevation of serum and ascites cancer antigen 125 levels in patients with liver cirrhosis. (14535990)
2003
39
Polymorphisms in the DNA repair gene XRCC1 and susceptibility to alcoholic liver cirrhosis in older Southeastern Brazilians. (12175549)
2002
40
Mechanisms of endotoxin tolerance in patients with alcoholic liver cirrhosis: role of interleukin 10, interleukin 1 receptor antagonist, and soluble tumour necrosis factor receptors as well as effector cell desensitisation. (10896923)
2000
41
Therapy of acute variceal hemorrhage and spontaneous bacterial peritonitis in liver cirrhosis]. (9789469)
1998
42
Growth hormone-stimulated insulin-like growth factor (IGF) I and IGF-binding protein-3 in liver cirrhosis. (9382965)
1997
43
Hepatic stellate cells and intralobular innervation in human liver cirrhosis. (9269832)
1997
44
Serum and ascitic levels of soluble intercellular adhesion molecule-1 in patients with alcoholic liver cirrhosis: relation to biochemical markers of disease activity and alcohol intake. (8865970)
1996
45
Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats. (8690730)
1995
46
Effects of alcohol and liver cirrhosis on the GH-IGF-I axis. (8679009)
1995
47
Predictive analysis of the response to treatment with diuretics of patients with liver cirrhosis and ascites]. (8562191)
1995
48
Anesthetic management for a patient with citrullinemia and liver cirrhosis]. (7699832)
1995
49
Endogenous digitalis-like factor in liver cirrhosis and cholestasis]. (7483706)
1993
50
Mechanism of feminization in male patients with non-alcoholic liver cirrhosis: role of sex hormone-binding globulin. (1916151)
1991

Variations for Liver Cirrhosis

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Expression for genes affiliated with Liver Cirrhosis

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Search GEO for disease gene expression data for Liver Cirrhosis.

Pathways for genes affiliated with Liver Cirrhosis

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Pathways related to Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ADH1B, ADH1C
29.9CYP2E1, CYP2A6
39.9CYP2E1, CYP2A6
49.8F2, IGFBP3
5
Show member pathways
mitochondrial L-carnitine shuttle pathway36
Saturated fatty acid biosynthesis58
9.8ALDH2, ADH1C, ADH1B
6
Show member pathways
acetate conversion to acetyl-CoA36
oxidative ethanol degradation III36
ethanol degradation IV36
9.7ALDH2, ADH1B, CYP2E1
7
Show member pathways
bupropion degradation36
methylglyoxal degradation III36
nicotine degradation III36
nicotine degradation IV36
9.7ADH1B, CYP2E1, CYP2A6
89.6HGF, TGFB1
9
Show member pathways
Retinol metabolism58
9.6CYP2E1, ALDH2, CYP2A6
109.5CYP2E1, NAT2, CYP2A6
11
Show member pathways
9.5CYP2A6, CYP2E1, NAT2
12
Show member pathways
phenylalanine utilization36
noradrenaline and adrenaline degradation36
phenylalanine degradation IV36
9.5ALDH2, TAT, ADH1C, ADH1B
13
Show member pathways
9.5ALDH2, CYP2A6, NAT2
14
Show member pathways
9.4ALB, TGFB1, HGF
159.4CYP2A6, AKR1A1, CYP2E1
169.3TAT, ALB, TTR, F2
17
Show member pathways
glycolysis36
gluconeogenesis36
Glycolysis and Gluconeogenesis36
9.2ADH1C, ADH1B, ALDH2, AKR1A1
18
Show member pathways
9.2ADH1C, ALDH2, AKR1A1, ADH1B
19
Show member pathways
9.2HGF, GHRH, F2, TGFB1
20
Show member pathways
9.2CYP2A6, CYP2E1, ADH1C, ADH1B, ALDH2
21
Show member pathways
9.1NAT2, CYP2E1, ADH1C, ADH1B, CYP2A6
22
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)36
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA36
tryptophan degradation36
glutaryl-CoA degradation36
serotonin degradation36
NAD de novo biosynthesis36
superpathway of melatonin degradation36
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde36
tryptophan utilization I36
melatonin degradation I36
9.1ALDH2, AKR1A1, ADH1B, CYP2A6
23
Show member pathways
8.3CYP2E1, CYP2A6, NAT2, ADH1C, ADH1B, AKR1A1
24
Show member pathways
6.9AKR1A1, ADH1C, TAT, CYP2E1, ADH1B, NAT2

Compounds for genes affiliated with Liver Cirrhosis

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Compounds related to Liver Cirrhosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 275)
idCompoundScoreTop Affiliating Genes
1hepaplastin439.9GPT, F2, HGF, ALB
2antipyrine43 1210.6ALB, CYP2E1, CYP2A6, F2
3sevoflurane49 43 1211.6CYP2E1, CYP2A6, GPT, ALB
4dimethylnitrosamine439.6NAT2, CYP2A6, CYP2E1, HGF
5pyrazole43 1210.5CYP2E1, ADH1C, AKR1A1, CYP2A6
6trichloroethylene439.5AKR1A1, GPT, NAT2, CYP2E1
7warfarin43 49 24 1212.4ALB, NAT2, GPT, CYP2A6, F2
8isoniazid43 49 1211.3NAT2, GPT, CYP2E1, CYP2A6
9rifampicin43 28 5911.3TAT, CYP2A6, NAT2, CYP2E1, GPT
10disulfiram43 49 59 1212.2CYP2A6, AKR1A1, ALDH2, GPT, CYP2E1
11nash439.2AKR1A1, CYP2E1, GPT, TGFB1
12acetaminophen43 2 49 24 1213.2CYP2E1, CYP2A6, NAT2, HGF, F2, GPT
13rsai439.1ALDH2, AKR1A1, NAT2, ADH1B, ADH1C, CYP2E1
14zidovudine43 49 1211.0ALB, CYP2A6, GPT, TGFB1, TAT
15NADP249.0CYP2A6, ALDH2, AKR1A1, ADH1B, ADH1C, CYP2E1
16prednisolone43 28 1211.0ALB, HGF, GPT, CYP2A6, IGFBP3, TAT
17theophylline43 28 24 1212.0GHRH, TGFB1, TTR, CYP2E1, CYP2A6
18valproic acid43 49 24 1211.9IGFBP3, ALB, GPT, CYP2E1, CYP2A6
19phenobarbital43 28 49 1211.9CYP2A6, AKR1A1, CYP2E1, HGF, GPT
20acetaldehyde28 43 2410.8CYP2A6, CYP2E1, ADH1C, ADH1B, ALDH2, AKR1A1
21thyroxine43 249.7GPT, TGFB1, GHRH, TTR, IGFBP3, ALB
22formaldehyde43 249.7ADH1C, CYP2A6, CYP2E1, TGFB1, AKR1A1, ALDH2
23betacarotene438.6IGFBP3, CYP2E1, TTR, TGFB1, NAT2, ALDH2
24estradiol43 24 1210.6CYP2E1, GHRH, CYP2A6, TAT, HGF, IGFBP3
25alpha tocopherol438.5TTR, ALB, ALDH2, IGFBP3, GPT
26hyaluronic acid43 249.5TGFB1, TTR, GPT, IGFBP3, F2, HGF
27rosiglitazone28 43 49 24 1212.4IGFBP3, PLIN2, CYP2A6, GPT, TGFB1, ALB
28dopamine43 28 24 1211.3ALDH2, GHRH, AKR1A1, ADH1B, TTR, CYP2E1
29cyclosporin a43 28 5910.3F2, IGFBP3, TGFB1, HGF, GPT, TTR
30methotrexate49 43 1210.3F2, NAT2, TAT, ALB, HGF, TGFB1
31folate438.2HGF, TTR, ALDH2, ALB, IGFBP3, NAT2
32vitamin d438.2ALB, HGF, GHRH, TGFB1, TTR, GPT
33testosterone43 59 24 1211.2ALB, TAT, IGFBP3, GHRH, HGF, TTR
34glycerol43 24 1210.0CYP2E1, TAT, PLIN2, AKR1A1, ADH1B, IGFBP3
35cholesterol43 28 24 1210.9GHRH, ALB, TTR, PLIN2, NAT2, GPT
36glutamine437.8TAT, IGFBP3, GPT, TTR, ALDH2, HGF
37glutamate437.7IGFBP3, ALDH2, HGF, GHRH, AKR1A1, TTR
38arginine437.7HGF, GHRH, TTR, GPT, ALDH2, TAT
39aspartate437.7IGFBP3, HGF, F2, TAT, ALDH2, GPT
40cysteine437.7TTR, ALDH2, TAT, AHSG, ALB, AKR1A1
41dexamethasone43 49 28 1210.7TGFB1, TTR, CYP2E1, CYP2A6, IGFBP3, TAT
42glucose437.6AHSG, TTR, PLIN2, GHRH, ALB, TAT
43lactate437.5GPT, CYP2E1, TAT, TTR, AKR1A1, HGF
44creatinine437.4IGFBP3, AKR1A1, ALB, ALDH2, HGF, TGFB1
45alanine437.4F2, IGFBP3, TTR, HGF, ALB, ALDH2
46vitamin a43 24 129.4ALB, ALDH2, IGFBP3, AKR1A1, ADH1B, ADH1C
47retinoic acid43 248.4AKR1A1, TGFB1, TTR, CYP2E1, CYP2A6, IGFBP3
48lipid437.3CYP2E1, GPT, AKR1A1, PLIN2, GHRH, HGF
49ethanol43 49 24 1210.3AKR1A1, ALDH2, GHRH, TAT, CYP2E1, AHSG
50estrogen437.3AHSG, TTR, TGFB1, NAT2, AKR1A1, GHRH

GO Terms for genes affiliated with Liver Cirrhosis

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Cellular components related to Liver Cirrhosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.4HGF, ALB, TGFB1
2blood microparticleGO:00725629.0AHSG, TGFB1, ALB, F2
3extracellular spaceGO:00056157.3AKR1A1, HGF, GHRH, TGFB1, TTR, AHSG
4extracellular regionGO:00055767.1ALB, F2, HGF, GHRH, PLIN2, TGFB1

Biological processes related to Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1response to mercury ionGO:004668910.0TAT, ALB
2ethanol oxidationGO:00060699.9ADH1C, ALDH2, ADH1B
3positive regulation of collagen biosynthetic processGO:00329679.8TGFB1, F2
4positive regulation of insulin-like growth factor receptor signaling pathwayGO:00435689.7IGFBP3, GHRH
5platelet degranulationGO:00025769.4ALB, HGF, TGFB1
6platelet activationGO:00301689.3F2, HGF, ALB, TGFB1
7xenobiotic metabolic processGO:00068059.0ALDH2, CYP2A6, CYP2E1, NAT2, ADH1C, ADH1B
8blood coagulationGO:00075968.9F2, HGF, ALB, TGFB1
9small molecule metabolic processGO:00442817.6TAT, ADH1C, ADH1B, PLIN2, ALB, ALDH2

Molecular functions related to Liver Cirrhosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:00301709.7GPT, ALB, TAT
2oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenGO:00167129.6CYP2A6, CYP2E1
3growth factor activityGO:00080839.4F2, TGFB1, HGF
4enzyme bindingGO:00198999.0CYP2A6, CYP2E1, TGFB1, ALB

Products for genes affiliated with Liver Cirrhosis

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Sources for Liver Cirrhosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet