MCID: LVR012
MIFTS: 69

Liver Cirrhosis malady

Summaries for Liver Cirrhosis

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Cirrhosis is scarring of the liver. scar tissue forms because of injury or long-term disease. scar tissue cannot do what healthy liver tissue does - make protein, help fight infections, clean the blood, help digest food and store energy. cirrhosis can lead to easy bruising or bleeding, or nosebleeds swelling of the abdomen or legs extra sensitivity to medicines high blood pressure in the vein entering the liver enlarged veins called varices in the esophagus and stomach. varices can bleed suddenly. kidney failure jaundice severe itching gallstones a small number of people with cirrhosis get liver cancer. your doctor will diagnose cirrhosis with blood tests, imaging tests, or a biopsy. cirrhosis has many causes. in the united states, the most common causes are chronic alcoholism and hepatitis. nothing will make the scar tissue disappear, but treating the cause can keep it from getting worse. if too much scar tissue forms, you may need to consider a liver transplant. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Liver Cirrhosis, also known as cirrhosis, is related to alcoholic liver cirrhosis and hepatitis c. An important gene associated with Liver Cirrhosis is ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide), and among its related pathways are Metabolism and Biological oxidations. The drugs bumetanide and ethacrynate sodium and the compounds ethanol and aspartate have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and liver/biliary system.

Wikipedia:64 Cirrhosis /sɪˈroʊsɪs/ is a result of advanced liver disease. It is characterized by replacement of... more...

Aliases & Classifications for Liver Cirrhosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 34MedlinePlus, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

liver cirrhosis 8 10 45 31 61
cirrhosis 8 45 34 61
cirrhosis of liver nos 8
cirrhosis of liver 8


External Ids:

Disease Ontology8 DOID:5082
NCIt40 C2951
MeSH35 D008103

Related Diseases for Liver Cirrhosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Liver Cirrhosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 528)
idRelated DiseaseScoreTop Affiliating Genes
1alcoholic liver cirrhosis31.7GPT, HGF
2hepatitis c31.5LSL, IFNA1, CYP2E1, F2, ASGR2, GPT
3hepatitis a31.3F2
4portal hypertension31.1F2, ALB, GPT
5hepatitis e31.1GPT
6hepatitis d31.1IFNA1, GPT
7hepatitis b31.0ALB, F2, ASGR2, GPT, IFNA1
8portal vein thrombosis30.9F2
9hypersplenism30.8F2
10alcoholic hepatitis30.8F2, GPT, ALB
11viral hepatitis30.7ADH1B, F2, GPT, CYP2A6, AKR1A1, IFNA1
12alcoholic pancreatitis30.7ADH1B, ALDH2, CYP2E1, ADH1C, AKR1A1
13pancreatitis, chronic30.6AKR1A1, CYP2E1, TTR, ALDH2, ADH1C, ADH1B
14insulin resistance30.6AHSG, LSL, IGFBP3, TTR, CYP2E1, GPT
15primary biliary cirrhosis30.5GPT, ASGR2, ALB, F2
16thrombocytopenia30.5IFNA1, GPT, F2, ALB
17tuberculosis30.4TAT, LSL, ALB, NAT2, CYP2A6, AKR1A1
18fatty liver disease30.3AHSG, GPT, PLIN2, ALDH2, CYP2E1, CYP2A6
19acute liver failure30.3GPT, F2, HGF, ALB
20autoimmune hepatitis30.3GPT, F2, ASGR2, IFNA1
21sepsis30.3ALB, F2, LSL, TTR
22alcohol abuse30.2AKR1A1, CYP2E1, GPT, ALDH2, ADH1C
23acute pancreatitis30.2ALDH2, ADH1C, ADH1B, GPT
24leukopenia30.2F2, ALB, IFNA1, GPT
25obstructive jaundice30.2TTR, GPT, AKR1A1
26hypoglycemia30.2IGFBP3, LSL, GHRH
27cystic fibrosis30.2ALB, NAT2
28siderosis30.2GPT
29cryoglobulinemia30.2IFNA1
30turner syndrome30.2IGFBP3
31systemic lupus erythematosus30.1F2, NAT2, AHSG, IFNA1
32adenoma30.0ADH1C, NAT2, CYP2A6, IGFBP3, GHRH
33adenocarcinoma30.0CYP2A6, NAT2, TAT, ALDH2, ADH1C, ADH1B
34atherosclerosis29.9LSL, ALB, PLIN2, AHSG
35thyroiditis29.9IFNA1
36glucose intolerance29.9IGFBP3, LSL, GPT, ALDH2
37acromegaly29.9LSL, GHRH, IGFBP3
38uremia29.9LSL, AHSG, ALB
39alcohol dependence29.9ADH1B, ALDH2
40arthritis29.9TAT, ALB
41biliary atresia29.9GPT, HGF
42hypertriglyceridemia29.9LSL, GPT
43wilson disease29.9GPT
44dysfibrinogenemia29.9F2
45colorectal cancer29.8HGF, ADH1C, CYP2A6, CYP2E1, IGFBP3, AKR1A1
46vasculitis29.8ALB, TAT, F2
47hypercholesterolemia29.8GPT
48squamous cell carcinoma29.6ALDH2, NAT2, CYP2E1, HGF, CYP2A6, ADH1B
49brain disease29.6F2, GPT, ALB, TAT
50hyperhomocysteinemia29.6F2, TTR, ALB

Graphical network of the top 20 diseases related to Liver Cirrhosis:



Diseases related to liver cirrhosis

Clinical Features for Liver Cirrhosis

Drugs & Therapeutics for Liver Cirrhosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Liver Cirrhosis

Drug clinical trials:

Search ClinicalTrials for Liver Cirrhosis

Search NIH Clinical Center for Liver Cirrhosis

Search CenterWatch for Liver Cirrhosis

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Liver Cirrhosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Liver Cirrhosis:
Autologous bone marrow-derived mesenchymal stem cells for liver cirhosis
Autologous bone marrow-derived stem cells for treatment of liver cirrhosis
Autologous hematopoietic stem cells for treatment of end-stage chronic liver disease
Bone marrow-derived endothelial progenitor cells for advanced liver cirrhosis
Bone marrow-derived mesenchymal stem cells for treatment of cirrhosis-related refractory ascites
Bone marrow-derived mesenchymal stem cells for treatment of liver cirrhosis
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Mesenchymal stem cells for liver cirrhosis
NU215-01, human umbilical cord mesenchymal stem cells for treatment of liver cirrhosis
Peripheral blood-derived CD34+ or mononuclear cells for liver cirrhosis
StempeucelLC
Umbilical cord-derived mesenchymal stem cells for treatment of liver cirrhosis
Embryonic/Adult Cultured Cells Related to Liver Cirrhosis:
Bone marrow-derived mesenchymal stem cells (family), PMIDs: 21771778, 22121493
Bone marrow-derived mesenchymal stem cells (family), PMID: 22121493
Peripheral blood-derived hematopoietic stem cells, PMID: 20587151
Bone marrow-derived endothelial progenitor cells (family)
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mesenchymal stem cells (family)
Hepatocytes
Bone marrow-derived mesenchymal stem cells (family)
Umbilical cord-derived mesenchymal stem cells
Peripheral blood-derived mesenchymal stem cells (family)
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444
Umbilical cord-derived mesenchymal stem cells (family)

Genetic Tests for Liver Cirrhosis

Anatomical Context for Liver Cirrhosis

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Liver Cirrhosis:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
3 LiverSinusoidsHepatic Stellate Cells Affected by disease
4 LiverLiver LobuleHepatocytes Affected by disease
5 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
6 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Liver Cirrhosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Liver Cirrhosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.5ADH1C, AKR1A1, GHRH, IGFBP3, AHSG, CYP2E1
2MP:000537011.1GHRH, IGFBP3, CYP2E1, PLIN2, ALB, HGF

Publications for Liver Cirrhosis

Sources:
51PubMed
See all sources

Articles related to Liver Cirrhosis:

(show top 50)    (show all 1682)
idTitleAuthorsYear
1
Dose-finding trial of tolvaptan in liver cirrhosis patients with hepatic edema: A randomized, double-blind, placebo-controlled trial. (23530991)
2014
2
Abdominal imaging can misdiagnose submassive hepatic necrosis as cirrhosis in acute liver failure. (23647426)
2013
3
A patient with Simpson-Golabi-Behmel syndrome, biliary cirrhosis and successful liver transplantation. (24357529)
2013
4
Oral glutamine challenge improves the performance of psychometric tests for the diagnosis of minimal hepatic encephalopathy in patients with liver cirrhosis. (24078984)
2013
5
Unusual cause of bleeding in liver cirrhosis patient. (22886231)
2013
6
Screening of hepatopulmonary syndrome (HPS) with CEUS and pulse-oximetry in liver cirrhosis patients eligible for liver transplant. (24157113)
2013
7
A Simple Noninvasive Score Based on Routine Parameters can Predict Liver Cirrhosis in Patients With Chronic Hepatitis C. (23967022)
2013
8
Single-dose application of antithrombin as a potential alternative anticoagulant during continuous renal replacement therapy in critically ill patients with advanced liver cirrhosis: a retrospective data analysis. (23400980)
2013
9
Blood neutrophil-to-lymphocyte ratio independently predicts survival in patients with liver cirrhosis. (23249602)
2013
10
Gastric ischemia after epinephrine injection in a patient with liver cirrhosis. (23372366)
2013
11
Genetic polymorphisms of genes coding to alcohol-metabolizing enzymes in western Mexicans: association of CYP2E1*c2/CYP2E1*5B allele with cirrhosis and liver function. (21895718)
2012
12
Psychometric hepatic encephalopathy score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis. (22743001)
2012
13
Assessment of splenic perfusion in patients with malignant hematologic diseases and spleen involvement, liver cirrhosis and controls using volume perfusion CT (VPCT): a pilot study. (22326669)
2012
14
Iliopsoas muscle hematoma secondary to alcoholic liver cirrhosis. (23185153)
2012
15
Readthrough acetylcholinesterase is increased in human liver cirrhosis. (23028565)
2012
16
Transient elastography to rule out esophageal varices and portal hypertensive gastropathy in HIV-infected individuals with liver cirrhosis. (22781218)
2012
17
Coated transjugular intrahepatic portosystemic shunt does not improve thrombocytopenia in patients with liver cirrhosis. (22588242)
2012
18
Obstructive jaundice due to ductus hepaticus communis cyst in patient with liver cirrhosis. (22156359)
2011
19
Reversal of liver cirrhosis in autoimmune hepatitis. (22234080)
2011
20
Cystic fibrosis-cirrhosis, portal hypertension, and liver biopsy: Reply. (21374683)
2011
21
Minimal hepatic encephalopathy in patients with decompensated liver cirrhosis. (22384773)
2011
22
Pure laparoscopic hepatectomy for hepatocellular carcinoma patients with severe liver cirrhosis. (22776279)
2011
23
Effects of testosterone gel treatment in hypogonadal men with liver cirrhosis. (22074639)
2011
24
Focal nodular hyperplasia-like nodule with reduced expression of organic anion transporter 1B3 in alcoholic liver cirrhosis. (21628934)
2011
25
Evaluation of quantitative portal venous, hepatic arterial, and total hepatic tissue blood flow using xenon CT in alcoholic liver cirrhosis-comparison with liver cirrhosis related to hepatitis C virus and nonalcoholic steatohepatitis. (18986379)
2010
26
Reactive lymphoid hyperplasia of the liver associated with primary biliary cirrhosis. (20581780)
2010
27
Polymorphism in glutathione-S-transferases: a risk factor in alcoholic liver cirrhosis. (19157724)
2009
28
Endoscopic argon plasma coagulation for the treatment of gastric antral vascular ectasia-related bleeding in patients with liver cirrhosis. (19329853)
2009
29
Altered liver morphology after portal vein thrombosis: not always cirrhosis. (18270830)
2008
30
Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. (17454860)
2007
31
Clinical challenges and images in GI. Image 2. Perforative peritonitis on sclerosing encapsulating peritonitis (abdominal cocoon) in a patient with alcoholic liver cirrhosis. (17383416)
2007
32
Human serum fetuin A/alpha2HS-glycoprotein level is associated with long-term survival in patients with alcoholic liver cirrhosis, comparison with the Child-Pugh and MELD scores. (17394649)
2007
33
Angiopoietin-2 serum levels are elevated in patients with liver cirrhosis and hepatocellular carcinoma. (17581268)
2007
34
Variceal upper digestive bleeding--an ever new complication in liver cirrhosis]. (17595842)
2007
35
Preemptive therapy with pegylated interferon alpha-2b and ribavirin after liver transplantation for hepatitis C cirrhosis. (16298583)
2005
36
The relationship between the plasma homocysteine level and the polymorphism of MTHFR gene C667T in liver cirrhosis]. (16381636)
2005
37
The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes. (15364537)
2004
38
Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. (15013444)
2004
39
Pseudogout and gout in a patient after liver transplantation for primary biliary cirrhosis: what might be the association? (17041459)
2003
40
The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteritis, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver. (11092254)
2000
41
Growth hormone-stimulated insulin-like growth factor (IGF) I and IGF-binding protein-3 in liver cirrhosis. (9382965)
1997
42
The choice of antibiotic therapy for bacterial infections in patients with cirrhosis of the liver]. (14966393)
1997
43
Preventive and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis. (9214455)
1997
44
Metabolic bone disease of liver cirrhosis: is it parallel to the clinical severity of cirrhosis? (8743912)
1996
45
Primary biliary liver cirrhosis in patients treated at Szczecin hospitals in 1978-1988]. (1669045)
1991
46
Adult Fanconi syndrome and liver cirrhosis. (2134330)
1990
47
Impaired early insulin response to intravenous glucose in alcoholic liver cirrhosis. (3296134)
1987
48
Cause of primary vaginal hydrocele and ascites in advanced liver cirrhosis. (6638271)
1983
49
Plasma catecholamines in hepatic coma and liver cirrhosis: role of octopamine. (6795387)
1981
50
Cirrhosis of the liver and color blindness. (5318495)
1965

Genetic Variations for Liver Cirrhosis

Expression for genes affiliated with Liver Cirrhosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Liver Cirrhosis

Search GEO for disease gene expression data for Liver Cirrhosis.

Pathways for genes affiliated with Liver Cirrhosis

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore
See all sources

Pathways related to Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.3GPT, ADH1C, ALB, ALDH2, NAT2, ADH1B
2
Hide members
11.2NAT2, AKR1A1, CYP2E1, CYP2A6, ALDH2, ADH1C
3
Hide members
11.1ADH1C, ALDH2, CYP2A6, CYP2E1, ADH1B, AKR1A1
4
Hide members
11.0NAT2, CYP2E1, ADH1B, ADH1C, CYP2A6
510.9ALB, TTR, F2, TAT
6
Hide members
10.9ADH1C, ADH1B, ALDH2, AKR1A1
7
Hide members
10.9ADH1B, CYP2A6, AKR1A1, ALDH2
8
Hide members
10.8ADH1B, ADH1C, ALDH2
9
Hide members
10.8ALDH2, ADH1C, ADH1B
10
Hide members
10.8CYP2E1, ALDH2, ADH1B
11
Hide members
10.8CYP2E1, ADH1B, CYP2A6
12
Retinol metabolism
Hide members
10.8CYP2E1, CYP2A6, ALDH2
13
Hide members
10.8CYP2E1, CYP2A6, NAT2
14
Acetaminophen metabolism
Hide members
10.8NAT2, CYP2A6, CYP2E1
15
Naphthalene metabolism
Hide members
10.8CYP2A6, AKR1A1, CYP2E1
16
Hide members
10.7ADH1C, ADH1B
17
Hide members
10.7ALDH2, ADH1B

Compounds for genes affiliated with Liver Cirrhosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Liver Cirrhosis according to GeneCards/GeneDecks:

(show top 50)    (show all 231)
idCompoundScoreTop Affiliating Genes
1ethanol45 50 11 2415.2GPT, HGF, LSL, TAT, CYP2E1, AKR1A1
2aspartate4512.2HGF, IFNA1, LSL, AKR1A1, GHRH, ALDH2
3vitamin a45 11 2414.1GPT, NAT2, IGFBP3, AKR1A1, HGF, CYP2E1
4alanine4512.0TAT, IGFBP3, ALDH2, AKR1A1, GPT, F2
5lactate4511.9AKR1A1, LSL, ALB, GPT, HGF, TTR
6creatinine4511.9LSL, ALDH2, TTR, F2, GPT, CYP2E1
7glycerol45 11 2413.8ADH1B, LSL, IGFBP3, CYP2E1, AKR1A1, TAT
8testosterone45 60 11 2414.8CYP2A6, CYP2E1, GHRH, LSL, TTR, HGF
9cholesterol45 29 11 2414.8PLIN2, TTR, LSL, GHRH, IGFBP3, NAT2
10prednisolone45 29 1113.7TAT, IGFBP3, LSL, ALB, IFNA1, HGF
11methotrexate45 50 1113.7NAT2, IGFBP3, GPT, LSL, HGF, TAT
12arginine4511.7ALDH2, GHRH, IGFBP3, TAT, TTR, GPT
13lipid4511.7HGF, LSL, TAT, GHRH, AKR1A1, ALB
14dopamine45 29 11 2414.7AKR1A1, ADH1B, CYP2A6, TAT, CYP2E1, TTR
15rsai4511.6LSL, AKR1A1, CYP2E1, NAT2, ALDH2, ADH1C
16acetaldehyde45 29 2413.6HGF, AKR1A1, CYP2E1, ADH1B, CYP2A6, ADH1C
17dexamethasone45 50 29 1114.6TAT, HGF, IFNA1, GHRH, CYP2E1, CYP2A6
18folate4511.6TTR, NAT2, HGF, AKR1A1, ALDH2, ALB
19vitamin d4511.5GHRH, GPT, HGF, AHSG, TTR, ALB
20glucose4511.5GHRH, LSL, ADH1B, IGFBP3, ALDH2, AHSG
21fibrinogen4511.5LSL, ALB, GPT, F2, TTR, TAT
22valproic acid45 50 11 2414.5CYP2A6, ALB, LSL, IGFBP3, GPT, CYP2E1
23rosiglitazone45 50 29 11 2415.5PLIN2, GPT, CYP2A6, IGFBP3, LSL, ALB
24thyroxine45 2412.4LSL, ALB, IGFBP3, GHRH, GPT, TTR
25hyaluronic acid45 2412.4HGF, IGFBP3, GPT, F2, TTR, ALB
26disulfiram45 60 1113.4AKR1A1, GPT, CYP2A6, ALDH2, CYP2E1
27ursodeoxycholic acid45 11 2413.4F2, GPT, CYP2E1, HGF, IFNA1
28tamoxifen45 50 29 1114.3GHRH, LSL, IFNA1, CYP2E1, CYP2A6
29rifampicin45 29 6013.3NAT2, TAT, CYP2A6, CYP2E1, GPT
30Fomepizole1111.3CYP2E1, CYP2A6, ADH1C, ADH1B
31hepaplastin4511.3ALB, F2, HGF, GPT
32acetaminophen45 2 50 11 2415.3GPT, CYP2A6, CYP2E1, NAT2
33retinoic acid45 2412.3IGFBP3, ALDH2, TTR, TAT, CYP2A6, CYP2E1
34estradiol45 11 2413.3CYP2E1, CYP2A6, TAT, GHRH
35dimethylnitrosamine4511.3NAT2, HGF, CYP2E1, CYP2A6
36glutamate4511.3GPT, GHRH, AKR1A1, ALDH2, TAT
37betacarotene4511.2CYP2E1, IGFBP3, TTR, ALDH2, NAT2
38trichloroethylene4511.2CYP2E1, GPT, NAT2, AKR1A1
39pyrazole45 1112.2CYP2A6, AKR1A1, CYP2E1, ADH1C
40estrogen4511.2AHSG, TTR, TAT
41triiodothyronine4511.1HGF, LSL, GHRH, TTR, IGFBP3
42nash4511.1CYP2E1, AKR1A1, LSL, GPT
43antipyrine45 1112.1CYP2A6, ALB, F2, CYP2E1
44sevoflurane45 1112.1ALB, GPT, CYP2A6, CYP2E1
45phenobarbital45 29 1113.1GPT, AKR1A1, CYP2E1, CYP2A6, HGF
46isoniazid50 45 1113.0GPT, CYP2A6, NAT2, CYP2E1
47zidovudine45 1112.0IFNA1, CYP2A6, TAT, GPT, ALB
48warfarin45 50 11 2414.0NAT2, CYP2A6
49cyclosporin a45 29 6012.9F2, TTR, GPT, TAT, IGFBP3, IFNA1
504-methylpyrazole4510.8CYP2A6, AKR1A1, CYP2E1

GO Terms for genes affiliated with Liver Cirrhosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Liver Cirrhosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.3GHRH, IGFBP3, AHSG, F2, TTR, PLIN2
2extracellular spaceGO:00561510.9ALB, HGF, GHRH, IGFBP3, AHSG, F2

Biological processes related to Liver Cirrhosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.5CYP2E1, CYP2A6, NAT2, TAT, GPT, PLIN2
2xenobiotic metabolic processGO:00680511.2ADH1B, CYP2E1, CYP2A6, NAT2, ALDH2, ADH1C
3ethanol oxidationGO:00606910.7ALDH2, ADH1C, ADH1B
4positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.7IGFBP3, GHRH
5response to mercury ionGO:04668910.4ALB, TAT

Molecular functions related to Liver Cirrhosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1electron carrier activityGO:00905510.8ALDH2, CYP2A6, CYP2E1, AKR1A1
2oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:01671210.7CYP2A6, CYP2E1
3pyridoxal phosphate bindingGO:03017010.5ALB, GPT, TAT

Products for genes affiliated with Liver Cirrhosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Liver Cirrhosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet