MCID: LVR013
MIFTS: 62

Liver Disease malady

Genetic diseases, Liver diseases, Rare diseases, Metabolic diseases categories

Aliases & Classifications for Liver Disease

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Liver Disease, Aliases & Descriptions:

Name: Liver Disease 30 9 11
Disorder of Liver 9
 
Hepatic Disorder 9
Liver Diseases 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Metabolic diseases
Anatomical: Liver diseases


External Ids:

Disease Ontology9 DOID:409
MeSH33 D008107
ICD9CM27 573.9
NCIt38 C3196

Summaries for Liver Disease

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Wikipedia:63 Liver disease (also called hepatic disease) is a type of damage to or disease of the liver. more...

MalaCards based summary: Liver Disease, also known as disorder of liver, is related to fatty liver disease and hepatitis. An important gene associated with Liver Disease is PRKCSH (protein kinase C substrate 80K-H), and among its related pathways are Eicosanoid Synthesis and Selenium Pathway. The drugs medium chain triglycerides and alglucerase and the compounds glycocholate and hepaplastin have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Related Diseases for Liver Disease

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Diseases in the Liver Disease family:

Infantile Liver Failure Syndrome 1 Infantile Liver Failure Syndrome 2
Liver Failure, Transient Infantile Acute Liver Failure
Liver Failure Acute Infantile Acute Infantile Liver Failure Due to Synthesis Defect of Mtdna-Encoded Proteins

Diseases related to Liver Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 501)
idRelated DiseaseScoreTop Affiliating Genes
1fatty liver disease32.6SLC17A5, CYP2E1
2hepatitis31.7F2, SERPINA1, GPT, GGT1, SLC17A5, CYP2E1
3hepatitis b31.4GPT, GGT1, SLC17A5, F2
4primary biliary cirrhosis31.3PDHX, DLAT
5alcoholic hepatitis31.2CYP2E1, F2
6cystic fibrosis31.2SERPINA1, ABCB11, SERPINA3, RBP4
7hepatitis c31.2CYP2E1, GGT1, GPT, F2, HFE, SERPINA1
8obesity31.1PNPLA3, SLC17A5, GGT1, RBP4, HFE, RETN
9neonatal hemochromatosis31.0SLC17A5, GGT1
10intrahepatic cholestasis31.0SLC17A5, GGT1, ABCB11
11portal hypertension31.0SLC17A5, GGT1, F2, GPT, RETN
12wilson disease31.0HFE, SLC17A5, GPT
13galactosemia30.9F2, GGT1, GPT, SLC17A5
14hepatitis a30.9F2
15acute liver failure30.9F2, GPT, SLC17A5
16cholelithiasis30.9GPT, GGT1, ABCB11
17emphysema due to aat deficiency30.9SERPINA1, SERPINA3
18thrombocytopenia30.9F2, GPT, HFE, SLC17A5
19cholangitis30.9SLC17A5, DLAT, GPT, GGT1
20autoimmune hepatitis30.9F2, SLC17A5, GPT, GGT1, DLAT
21hepatocellular carcinoma30.8DLAT, SERPINB3, HFE, SERPINA1, GGT1, SLC17A5
22obstructive jaundice30.8SLC17A5, GGT1, GPT
23alcohol dependence30.8CYP2E1, SLC17A5, GPT, GGT1
24hepatic encephalopathy30.8F2, GPT, SLC17A5
25viral hepatitis30.8HFE, SERPINA1, GPT, F2, GGT1, SLC17A5
26hepatitis e30.8GPT
27cholestasis, progressive familial intrahepatic 130.8ABCB11, GGT1
28alcohol abuse30.7SLC17A5, CYP2E1, GPT, HFE, GGT1
29siderosis30.7GPT, HFE
30pancreatitis30.7SERPINA1, GGT1, SLC17A5, CYP2E1
31cholestasis30.7RBP4, ABCB11, GPT, HSD3B7, SERPINA1, SLC17A5
32biliary atresia30.7GGT1, GPT
33pyridoxine deficiency30.6SLC17A5, GPT
34splenomegaly30.6GPT, SLC17A5
35coronary artery disease30.6HFE, RETN, GGT1
36cholangitis, primary sclerosing30.5DLAT, GPT, GGT1
37panniculitis30.5SERPINA1
38opisthorchiasis30.4GGT1
39glucose intolerance30.4RETN, RBP4, GPT
40alcoholic liver cirrhosis30.2CYP2E1, F2, GPT, HFE, GGT1, SLC17A5
41leukopenia30.2SLC17A5, F2, GPT
42liver cirrhosis30.1RBP4, HFE, SERPINA3, SERPINB3, SERPINA1, GPT
43primary hyperoxaluria29.9CYP2E1, SERPINA1, RETN, HFE, RBP4
44adenocarcinoma29.9SERPINA1, GGT1, SERPINB3, SERPINA3, CYP2E1, ABCB11
45substance abuse29.9GGT1, CYP2E1
46polycystic liver disease11.0
47hepatitis c virus10.7
48nonalcoholic steatohepatitis10.6
49pseudotumor cerebri10.5RBP4
50malignant histiocytosis10.5SERPINA3

Graphical network of the top 20 diseases related to Liver Disease:



Diseases related to liver disease

Symptoms for Liver Disease

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Drugs & Therapeutics for Liver Disease

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Drug clinical trials:

Search ClinicalTrials for Liver Disease

Search NIH Clinical Center for Liver Disease

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Liver Disease cell therapies at LifeMap Discovery.

Genetic Tests for Liver Disease

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Anatomical Context for Liver Disease

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MalaCards organs/tissues related to Liver Disease:

31
Liver, Bone, Testes, Kidney, Monocytes, Endothelial, T cells, Neutrophil, Bone marrow, Heart, Brain, Adipocyte, Lung, Thyroid, Ovary, Prostate, Pituitary, Skeletal muscle, Skin, B cells, Fetal liver, Spleen, Colon, Breast, Placenta, Whole blood, Pancreas

Animal Models for Liver Disease or affiliated genes

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MGI Mouse Phenotypes related to Liver Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.5CYP2E1, HSD3B7, PRKCSH, RETN, HFE, ABCB11
2MP:00053768.2SLC17A5, F2, ABCB11, CYP2E1, PNPLA3, HSD3B7

Publications for Liver Disease

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Articles related to Liver Disease:

(show top 50)    (show all 3217)
idTitleAuthorsYear
1
Nonalcoholic Fatty Liver Disease and Hyperuricemia: A Close Relation with Hepatic Insulin Resistance after Nicotinic Acid Treatment? (25350520)
2014
2
Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor I' activation. (23605066)
2013
3
Liver transplantation for alcoholic liver disease: a retrospective analysis of recidivism, survival and risk factors predisposing to alcohol relapse. (24261021)
2013
4
Pediatric non-alcoholic fatty liver disease: an increasing public health issue. (24068459)
2013
5
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. (22902550)
2013
6
Simple noninvasive systems predict long-term outcomes of patients with nonalcoholic fatty liver disease. (23860502)
2013
7
Oral probiotic microcapsule formulation ameliorates non-alcoholic fatty liver disease in Bio F1B Golden Syrian hamsters. (23554890)
2013
8
Prevalence of restless legs syndrome in Japanese patients with chronic liver disease. (22672613)
2012
9
The Seroconversion Rate of Hepatitis A Virus Vaccination among Patients with Hepatitis B Virus-Related Chronic Liver Disease in Korea. (21814604)
2011
10
Mammary duct ectasia in a man with liver disease, end stage renal failure, and adjacent arteriovenous fistula. (22470751)
2010
11
Usefulness of non-invasive markers for predicting significant fibrosis in patients with chronic liver disease. (20052350)
2010
12
Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study. (20825652)
2010
13
Congenital disorders of glycosylation in hepatology: the example of polycystic liver disease. (20138683)
2010
14
Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. (19523535)
2009
15
Prevalence of subclinical vitamin K deficiency in cholestatic liver disease. (19502999)
2009
16
Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease. (18713296)
2009
17
Serum adipokine levels in chronic liver diseases: association of resistin levels with fibrosis severity. (18609175)
2008
18
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. (18242210)
2008
19
Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? (17482764)
2007
20
The prevalence of peripheral iron overload and the presence of HFE gene (H63D) mutation among the Korean patients with nonalcoholic fatty liver disease]. (17585191)
2007
21
Serum C-reactive protein and liver disease in patients with melioidosis. (17262186)
2007
22
Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3',5'-cyclic monophosphate. (17383431)
2007
23
Methylenetetrahydrofolate reductase C677T mutation and nonalcoholic fatty liver disease. (17356914)
2007
24
Non-invasive markers to predict the liver fibrosis in non-alcoholic fatty liver disease. (16911470)
2006
25
Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. (16618517)
2006
26
Expression of epithelial cellular adhesion molecule (Ep-CAM) in chronic (necro-)inflammatory liver diseases and hepatocellular carcinoma. (16364680)
2006
27
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. (16799979)
2006
28
Nonalcoholic fatty liver disease in India--is it different? (17542290)
2006
29
The serum level of certain aminoacids in chronic liver diseases associated with impaired oral glucose tolerance. (17236290)
2006
30
The role of PPAR alpha in the pathogenesis of fatty liver disease]. (16174475)
2005
31
Hepatorenal syndrome: a dreaded complication of end-stage liver disease. (15667508)
2005
32
Management of fatty liver disease with vitamin E and C compared to ursodeoxycholic acid treatment. (16245220)
2005
33
Laparoscopic left lateral sectorectomy for polycystic liver disease. (12962449)
2003
34
Plasma P-selectin levels are elevated in patients with chronic liver disease. (12945872)
2003
35
C282Y and H63D mutations of HFE gene in patients with advanced alcoholic liver disease. (11469076)
2001
36
A useful ELISA system for human liver-type arginase, and its utility in diagnosis of liver diseases. (11676974)
2001
37
How is the liver primed or sensitized for alcoholic liver disease? (11391068)
2001
38
Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases. (11685552)
2001
39
Oxidative stress and antioxidant defense in alcoholic liver disease and chronic hepatitis C]. (10962902)
2000
40
Circulating intercellular adhesion molecule-1 in chronic liver disease and hepatocellular carcinoma. (10462824)
1999
41
Serum IgA antibodies to human gut luminal aspirates and human liver in alcoholic liver disease. (9802516)
1998
42
Hepatocellular carcinoma associated with alcoholic liver disease: a clinicopathological study and genetic polymorphism of aldehyde dehydrogenase 2. (8986242)
1996
43
Carbohydrate-deficient transferrin in alcohol and nonalcohol abusers with liver disease. (8749821)
1995
44
Liver transplantation for end-stage liver disease associated with alpha-1-antitrypsin deficiency in children: pretransplant natural history, timing and results of transplantation. (8201225)
1994
45
The prognosis of patients with alcoholic liver disease. An international randomized, placebo-controlled trial on the effect of malotilate on survival. (8051381)
1994
46
Detection of autoantibodies against M2, LKM-1, and SLA in liver diseases by standardized uniform ELISA-techniques. (7807283)
1994
47
Lecithin-cholesterol acyltransferase and lipid transfer protein activities in liver disease. (8446043)
1993
48
The role of cytokines in the pathophysiology of chronic liver diseases. (8123873)
1993
49
Minor role of hepatitis B virus in the causation of chronic liver disease in Somalia indicated by a case-control study. (1712517)
1991
50
The gallbladder in polycystic liver disease. (7054544)
1982

Variations for Liver Disease

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Expression for genes affiliated with Liver Disease

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Search GEO for disease gene expression data for Liver Disease.

Pathways for genes affiliated with Liver Disease

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Pathways related to Liver Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
aspirin triggered resolvin E biosynthesis36
10.0PNPLA3, GGT1
2
Show member pathways
thioredoxin pathway36
9.9GGT1, SERPINA3, F2
3
Show member pathways
9.1GPT, CYP2E1, PNPLA3, HSD3B7, PDHX, DLAT

Compounds for genes affiliated with Liver Disease

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Compounds related to Liver Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1glycocholate4310.3GPT, SLC17A5, ABCB11
2hepaplastin4310.3F2, SLC17A5, GPT
3vinylchloride4310.2GGT1, CYP2E1, SLC17A5
4sevoflurane49 43 1212.1GGT1, CYP2E1, SLC17A5, GPT
5aminopyrine4310.1SLC17A5, GGT1, GPT, F2
6alpha lipoic acid4310.1SERPINA1, PDHX, DLAT, GGT1
7isoflurane49 43 1212.1SLC17A5, GGT1, CYP2E1, GPT
8antipyrine43 1211.1CYP2E1, SLC17A5, GGT1, F2
9lutein4310.0SERPINA3, RBP4, GGT1
10disulfiram43 49 59 1213.0SLC17A5, CYP2E1, GPT, GGT1
11vitamin b124310.0GGT1, SERPINA3, SLC17A5, GPT
12phosphorus4310.0SLC17A5, RBP4, GGT1, GPT
13rifampicin43 28 5912.0CYP2E1, ABCB11, GPT, GGT1, SLC17A5
14pyruvate4310.0DLAT, SLC17A5, PDHX, HFE, GPT
15phenobarbital43 28 49 1213.0GGT1, GPT, SLC17A5, CYP2E1, ABCB11
16nevirapine43 49 1211.9GGT1, GPT, SLC17A5
17betacarotene439.9SLC17A5, CYP2E1, GGT1, RBP4, SERPINA3
18metformin43 49 1211.9GGT1, RETN, SLC17A5, GPT
19verapamil43 28 49 24 1213.9ABCB11, SLC17A5, CYP2E1, GPT, GGT1
20silymarin439.9SLC17A5, GPT, GGT1, F2, CYP2E1
21acetaminophen43 2 49 24 1213.9F2, CYP2E1, GPT, GGT1, SLC17A5
22vitamin-e439.9RBP4, SLC17A5, GGT1, GPT
23isoniazid43 49 1211.9GPT, CYP2E1, SLC17A5
24pioglitazone28 43 49 1212.9RETN, RBP4, SLC17A5, GGT1, GPT
25fibrinogen439.8GPT, SERPINA1, SERPINA3, RETN, SLC17A5, F2
26ursodeoxycholic acid43 24 1211.8SLC17A5, GGT1, ABCB11, F2, CYP2E1, GPT
27phospholipid439.8RBP4, PNPLA3, ABCB11, SLC17A5, F2, SERPINA1
28methotrexate49 43 1211.8SLC17A5, GGT1, SERPINA3, GPT, F2
29nash439.8CYP2E1, GPT, RETN, HFE, SLC17A5, GGT1
30ethanol43 49 24 1212.8GGT1, SLC17A5, GPT, SERPINA1, HFE, CYP2E1
31urea43 24 1211.8GPT, RETN, RBP4, SLC17A5, GGT1, SERPINA3
32thyroxine43 2410.7SLC17A5, GPT, SERPINA3, RETN, GGT1, RBP4
33ascorbic acid43 2410.7SLC17A5, GGT1, HFE, RBP4, SERPINA1, CYP2E1
34uric acid43 2410.7SLC17A5, GGT1, RBP4, HFE, RETN, GPT
35valproic acid43 49 24 1212.7GGT1, SLC17A5, CYP2E1, GPT
36tamoxifen43 49 28 1212.7SLC17A5, CYP2E1, GGT1, ABCB11, F2
37iron43 2410.6GGT1, SLC17A5, RBP4, SERPINA3, SERPINA1, GPT
38heparin43 28 24 1212.6SLC17A5, F2, PNPLA3, SERPINA1, GGT1, SERPINA3
39lactate439.5GGT1, SLC17A5, F2, GPT, RBP4, CYP2E1
40vitamin a43 24 1211.5GGT1, SERPINA1, CYP2E1, SERPINA3, SLC17A5, RETN
41aspartate439.5RBP4, HFE, GPT, F2, GGT1, SLC17A5
42estrogen439.4RBP4, HFE, F2, ABCB11, SERPINA1, SERPINA3
43creatinine439.2GPT, SERPINA1, SLC17A5, GGT1, RBP4, RETN
44cysteine439.2SERPINB3, GGT1, ABCB11, SERPINA1, CYP2E1, RBP4
45alanine439.2RETN, GPT, PNPLA3, F2, HFE, RBP4
46cholesterol43 28 24 1212.1SERPINA1, ABCB11, HFE, RBP4, GGT1, SLC17A5
47serine439.0SERPINA3, SERPINA1, GGT1, RBP4, PDHX, PNPLA3
48glucose439.0ABCB11, RETN, HFE, PDHX, RBP4, GGT1
49testosterone43 59 24 1212.0CYP2E1, RETN, HFE, RBP4, SLC17A5, GGT1
50lipid438.9PNPLA3, SLC17A5, SERPINA3, GGT1, RBP4, HFE

GO Terms for genes affiliated with Liver Disease

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Cellular components related to Liver Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700629.2GGT1, RBP4, SERPINA3, SERPINB3, SERPINA1, GPT

Biological processes related to Liver Disease according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1maintenance of gastrointestinal epitheliumGO:003027710.2RBP4, SERPINA3
2acute-phase responseGO:000695310.2SERPINA3, SERPINA1, F2
3regulation of acetyl-CoA biosynthetic process from pyruvateGO:001051010.2PDHX, DLAT
4pyruvate metabolic processGO:000609010.2DLAT, PDHX
5regulation of proteolysisGO:003016210.2SERPINA1, SERPINB3, SERPINA3
6negative regulation of endopeptidase activityGO:001095110.1SERPINA3, SERPINB3, SERPINA1
7negative regulation of proteolysisGO:004586110.0SERPINB3, F2
8bile acid biosynthetic processGO:00066999.9HSD3B7, ABCB11
9small molecule metabolic processGO:00442819.3GGT1, ABCB11, CYP2E1, PNPLA3, GPT, HSD3B7

Molecular functions related to Liver Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:000486710.0SERPINA3, SERPINB3, SERPINA1

Products for genes affiliated with Liver Disease

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Sources for Liver Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet