MCID: LVR013
MIFTS: 69

Liver Disease malady

Gastrointestinal diseases, Liver diseases, Rare diseases categories
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Summaries for Liver Disease

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33MalaCards
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MalaCards: Liver Disease, also known as liver disorder in pregnancy, is related to fatty liver disease and hepatitis. An important gene associated with Liver Disease is PRKCSH (protein kinase C substrate 80K-H), and among its related pathways are Eicosanoid Synthesis and Selenium Pathway. The drugs medium chain triglycerides and alglucerase and the compounds glycocholate and hepaplastin have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Aliases & Classifications for Liver Disease

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8Disease Ontology, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

liver disease 8 31
liver disorder in pregnancy 8 62
liver disorder in pregnancy, unspecified as to episode of care 8
liver disorder in pregnancy, with delivery 8
liver disorder in pregnancy unspecified 8
liver disorder in pregnancy - delivered 8
liver disorder in pregnancy nos 8
unspecified disorder of liver 8
liver disorder antepartum 8
disease of the liver 8
liver disorder nos 8
disorder of liver 8
hepatic disorder 8
disease of liver 8
liver disorder 8
liver diseases 62


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Disease Ontology8 DOID:409
ICD9CM27 573.9
MeSH35 D008107
NCIt40 C3196

Related Diseases for Liver Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Liver Disease family:

Acute Liver Failure

Diseases related to Liver Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 544)
idRelated DiseaseScoreTop Affiliating Genes
1fatty liver disease32.0CYP2E1, SLC17A5
2hepatitis31.7SLC17A5, GPT
3obesity31.1CYP2E1, PNPLA3, GPT, RETN, HFE, RBP4
4hepatitis c31.1F2, CYP2E1, GPT, SERPINA1, HFE, RBP4
5insulin resistance31.1CYP2E1, GPT, RETN, HFE, RBP4, GGT1
6hepatitis b31.1F2, GPT, GGT1, SLC17A5
7hepatocellular carcinoma31.0F2, CYP2E1, GPT, SERPINA1, SERPINB3, HFE
8hypertension30.8F2, RETN, GGT1
9cystic fibrosis30.8RBP4, SERPINA3, SERPINA1, ABCB11
10portal hypertension30.7F2, GPT, RETN, GGT1, SLC17A5
11primary biliary cirrhosis30.6PDHX, DLAT
12alcoholic hepatitis30.6F2, CYP2E1
13galactosemia30.6F2, GPT, GGT1, SLC17A5
14autoimmune hepatitis30.5SLC17A5, GGT1, DLAT, GPT, F2
15thrombocytopenia30.5SLC17A5, HFE, GPT, F2
16cholestasis30.5HSD3B7, GPT, ABCB11, F2, SERPINA1, RBP4
17diabetes mellitus30.5CYP2E1, GPT, SERPINA1, RETN, HFE, RBP4
18viral hepatitis30.5F2, GPT, SERPINA1, HFE, GGT1, SLC17A5
19neonatal hemochromatosis30.5GGT1, SLC17A5
20intrahepatic cholestasis30.4ABCB11, GGT1, SLC17A5
21liver cirrhosis30.4SLC17A5, GGT1, RBP4, HFE, RETN, SERPINA3
22acute liver failure30.4SLC17A5, GPT, F2
23alcohol abuse30.4CYP2E1, GPT, HFE, GGT1, SLC17A5
24cholangitis30.4SLC17A5, GGT1, DLAT, GPT
25type 2 diabetes mellitus30.4GPT, RETN, RBP4, GGT1, SLC17A5
26cholelithiasis30.4ABCB11, GPT, GGT1
27obstructive jaundice30.3GPT, GGT1, SLC17A5
28wilson disease30.3GPT, HFE, SLC17A5
29primary sclerosing cholangitis30.3GPT, DLAT, GGT1
30hepatic encephalopathy30.3SLC17A5, GPT, F2
31hepatitis a30.2F2
32coronary artery disease30.2GGT1, HFE, RETN
33emphysema due to aat deficiency30.2SERPINA1, SERPINA3
34pancreatitis30.2CYP2E1, SERPINA1, GGT1, SLC17A5
35hepatitis e30.1GPT
36siderosis30.1HFE, GPT
37splenomegaly30.1SLC17A5, GPT
38alcoholic liver cirrhosis30.0F2, CYP2E1, GPT, HFE, GGT1, SLC17A5
39hypercholesterolemia30.0SLC17A5, GGT1, RBP4, RETN, GPT
40pyridoxine deficiency30.0GPT, SLC17A5
41cholestasis, progressive familial intrahepatic 130.0ABCB11, GGT1
42biliary atresia30.0GGT1, GPT
43glucose intolerance29.9GPT, RETN, RBP4
44panniculitis29.8SERPINA1
45opisthorchiasis29.8GGT1
46primary hyperoxaluria29.7RBP4, HFE, RETN, SERPINA1, CYP2E1
47adenocarcinoma29.7ABCB11, CYP2E1, SERPINA1, SERPINB3, SERPINA3, GGT1
48substance abuse29.6CYP2E1, GGT1
49polycystic liver disease10.9
50hepatitis c virus10.7

Graphical network of the top 20 diseases related to Liver Disease:



Diseases related to liver disease

Symptoms for Liver Disease

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Drugs & Therapeutics for Liver Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Liver Disease

Search NIH Clinical Center for Liver Disease

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Liver Disease cell therapies at LifeMap Discovery.

Genetic Tests for Liver Disease

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Anatomical Context for Liver Disease

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Sources:
33MalaCards
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MalaCards organs/tissues related to Liver Disease:

33
Liver, Bone, Testes, Kidney, Monocytes, Endothelial, T cells, Bone marrow, Heart, Brain, Adipocyte, Lung, Thyroid, Pituitary, Prostate, B cells, Skin, Fetal liver, Skeletal muscle, Ovary, Placenta, Breast, Colon, Pancreas, Whole blood, Spleen

Animal Models for Liver Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Liver Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.5CYP2E1, HSD3B7, PRKCSH, RETN, HFE, ABCB11
2MP:00053768.2SLC17A5, F2, ABCB11, CYP2E1, PNPLA3, HSD3B7

Publications for Liver Disease

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Sources:
52PubMed
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Articles related to Liver Disease:

(show top 50)    (show all 3073)
idTitleAuthorsYear
1
Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor I' activation. (23605066)
2013
2
Liver transplantation for alcoholic liver disease: a retrospective analysis of recidivism, survival and risk factors predisposing to alcohol relapse. (24261021)
2013
3
Hepatitis and liver disease knowledge and preventive practices among health workers in Mexico: a cross-sectional study. (24097058)
2013
4
Pediatric non-alcoholic fatty liver disease: an increasing public health issue. (24068459)
2013
5
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. (22902550)
2013
6
IL28B polymorphisms are associated with severity ofA liver disease in human immunodeficiency virus (HIV) patients coinfected with hepatitis C virus. (23103287)
2013
7
Simple noninvasive systems predict long-term outcomes of patients with nonalcoholic fatty liver disease. (23860502)
2013
8
Oral probiotic microcapsule formulation ameliorates non-alcoholic fatty liver disease in Bio F1B Golden Syrian hamsters. (23554890)
2013
9
Prevalence of restless legs syndrome in Japanese patients with chronic liver disease. (22672613)
2012
10
The Seroconversion Rate of Hepatitis A Virus Vaccination among Patients with Hepatitis B Virus-Related Chronic Liver Disease in Korea. (21814604)
2011
11
Mammary duct ectasia in a man with liver disease, end stage renal failure, and adjacent arteriovenous fistula. (22470751)
2010
12
Usefulness of non-invasive markers for predicting significant fibrosis in patients with chronic liver disease. (20052350)
2010
13
Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study. (20825652)
2010
14
Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. (19523535)
2009
15
Prevalence of subclinical vitamin K deficiency in cholestatic liver disease. (19502999)
2009
16
Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease. (18713296)
2009
17
Serum adipokine levels in chronic liver diseases: association of resistin levels with fibrosis severity. (18609175)
2008
18
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. (18242210)
2008
19
Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? (17482764)
2007
20
The prevalence of peripheral iron overload and the presence of HFE gene (H63D) mutation among the Korean patients with nonalcoholic fatty liver disease]. (17585191)
2007
21
Serum C-reactive protein and liver disease in patients with melioidosis. (17262186)
2007
22
Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3',5'-cyclic monophosphate. (17383431)
2007
23
Methylenetetrahydrofolate reductase C677T mutation and nonalcoholic fatty liver disease. (17356914)
2007
24
Non-invasive markers to predict the liver fibrosis in non-alcoholic fatty liver disease. (16911470)
2006
25
Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. (16618517)
2006
26
Expression of epithelial cellular adhesion molecule (Ep-CAM) in chronic (necro-)inflammatory liver diseases and hepatocellular carcinoma. (16364680)
2006
27
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. (16799979)
2006
28
Nonalcoholic fatty liver disease in India--is it different? (17542290)
2006
29
The serum level of certain aminoacids in chronic liver diseases associated with impaired oral glucose tolerance. (17236290)
2006
30
The role of PPAR alpha in the pathogenesis of fatty liver disease]. (16174475)
2005
31
Hepatorenal syndrome: a dreaded complication of end-stage liver disease. (15667508)
2005
32
Laparoscopic left lateral sectorectomy for polycystic liver disease. (12962449)
2003
33
Plasma P-selectin levels are elevated in patients with chronic liver disease. (12945872)
2003
34
C282Y and H63D mutations of HFE gene in patients with advanced alcoholic liver disease. (11469076)
2001
35
A useful ELISA system for human liver-type arginase, and its utility in diagnosis of liver diseases. (11676974)
2001
36
How is the liver primed or sensitized for alcoholic liver disease? (11391068)
2001
37
Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases. (11685552)
2001
38
Oxidative stress and antioxidant defense in alcoholic liver disease and chronic hepatitis C]. (10962902)
2000
39
Circulating intercellular adhesion molecule-1 in chronic liver disease and hepatocellular carcinoma. (10462824)
1999
40
Serum IgA antibodies to human gut luminal aspirates and human liver in alcoholic liver disease. (9802516)
1998
41
Hepatocellular carcinoma associated with alcoholic liver disease: a clinicopathological study and genetic polymorphism of aldehyde dehydrogenase 2. (8986242)
1996
42
Carbohydrate-deficient transferrin in alcohol and nonalcohol abusers with liver disease. (8749821)
1995
43
Liver transplantation for end-stage liver disease associated with alpha-1-antitrypsin deficiency in children: pretransplant natural history, timing and results of transplantation. (8201225)
1994
44
The prognosis of patients with alcoholic liver disease. An international randomized, placebo-controlled trial on the effect of malotilate on survival. (8051381)
1994
45
Detection of autoantibodies against M2, LKM-1, and SLA in liver diseases by standardized uniform ELISA-techniques. (7807283)
1994
46
Genotypes of ALDH2 related to liver and pulmonary diseases and other genetic factors related to alcoholic liver disease. (7695791)
1994
47
Lecithin-cholesterol acyltransferase and lipid transfer protein activities in liver disease. (8446043)
1993
48
The role of cytokines in the pathophysiology of chronic liver diseases. (8123873)
1993
49
Minor role of hepatitis B virus in the causation of chronic liver disease in Somalia indicated by a case-control study. (1712517)
1991
50
The gallbladder in polycystic liver disease. (7054544)
1982

Variations for Liver Disease

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Expression for genes affiliated with Liver Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Liver Disease

Search GEO for disease gene expression data for Liver Disease.

Pathways for genes affiliated with Liver Disease

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG
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Pathways related to Liver Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
aspirin triggered resolvin E biosynthesis38
10.0PNPLA3, GGT1
2
Show member pathways
thioredoxin pathway38
9.9GGT1, SERPINA3, F2
3
Show member pathways
9.1GPT, CYP2E1, PNPLA3, HSD3B7, PDHX, DLAT

Compounds for genes affiliated with Liver Disease

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Liver Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1glycocholate4510.3GPT, SLC17A5, ABCB11
2hepaplastin4510.3F2, SLC17A5, GPT
3vinylchloride4510.2GGT1, CYP2E1, SLC17A5
4sevoflurane51 45 1112.1GGT1, CYP2E1, SLC17A5, GPT
5aminopyrine4510.1SLC17A5, GGT1, GPT, F2
6alpha lipoic acid4510.1SERPINA1, PDHX, DLAT, GGT1
7isoflurane51 45 1112.1SLC17A5, GGT1, CYP2E1, GPT
8antipyrine45 1111.1CYP2E1, SLC17A5, GGT1, F2
9lutein4510.0SERPINA3, RBP4, GGT1
10disulfiram45 51 61 1113.0SLC17A5, CYP2E1, GPT, GGT1
11vitamin b124510.0GGT1, SERPINA3, SLC17A5, GPT
12phosphorus4510.0SLC17A5, RBP4, GGT1, GPT
13rifampicin45 29 6112.0CYP2E1, ABCB11, GPT, GGT1, SLC17A5
14pyruvate4510.0DLAT, SLC17A5, PDHX, HFE, GPT
15phenobarbital45 29 51 1113.0GGT1, GPT, SLC17A5, CYP2E1, ABCB11
16nevirapine45 51 1111.9GGT1, GPT, SLC17A5
17betacarotene459.9SLC17A5, CYP2E1, GGT1, RBP4, SERPINA3
18metformin45 51 1111.9GGT1, RETN, SLC17A5, GPT
19verapamil45 29 51 24 1113.9ABCB11, SLC17A5, CYP2E1, GPT, GGT1
20silymarin459.9SLC17A5, GPT, GGT1, F2, CYP2E1
21acetaminophen45 3 51 24 1113.9F2, CYP2E1, GPT, GGT1, SLC17A5
22vitamin-e459.9RBP4, SLC17A5, GGT1, GPT
23isoniazid45 51 1111.9GPT, CYP2E1, SLC17A5
24pioglitazone29 45 51 1112.9RETN, RBP4, SLC17A5, GGT1, GPT
25fibrinogen459.8GPT, SERPINA1, SERPINA3, RETN, SLC17A5, F2
26ursodeoxycholic acid45 24 1111.8SLC17A5, GGT1, ABCB11, F2, CYP2E1, GPT
27phospholipid459.8RBP4, PNPLA3, ABCB11, SLC17A5, F2, SERPINA1
28methotrexate51 45 1111.8SLC17A5, GGT1, SERPINA3, GPT, F2
29nash459.8CYP2E1, GPT, RETN, HFE, SLC17A5, GGT1
30ethanol45 51 24 1112.8GGT1, SLC17A5, GPT, SERPINA1, HFE, CYP2E1
31urea45 24 1111.8GPT, RETN, RBP4, SLC17A5, GGT1, SERPINA3
32thyroxine45 2410.7SLC17A5, GPT, SERPINA3, RETN, GGT1, RBP4
33ascorbic acid45 2410.7SLC17A5, GGT1, HFE, RBP4, SERPINA1, CYP2E1
34uric acid45 2410.7SLC17A5, GGT1, RBP4, HFE, RETN, GPT
35valproic acid45 51 24 1112.7GGT1, SLC17A5, CYP2E1, GPT
36tamoxifen45 51 29 1112.7SLC17A5, CYP2E1, GGT1, ABCB11, F2
37iron45 2410.6GGT1, SLC17A5, RBP4, SERPINA3, SERPINA1, GPT
38heparin45 29 24 1112.6SLC17A5, F2, PNPLA3, SERPINA1, GGT1, SERPINA3
39lactate459.5GGT1, SLC17A5, F2, GPT, RBP4, CYP2E1
40vitamin a45 24 1111.5GGT1, SERPINA1, CYP2E1, SERPINA3, SLC17A5, RETN
41aspartate459.5RBP4, HFE, GPT, F2, GGT1, SLC17A5
42estrogen459.4RBP4, HFE, F2, ABCB11, SERPINA1, SERPINA3
43creatinine459.2GPT, SERPINA1, SLC17A5, GGT1, RBP4, RETN
44cysteine459.2SERPINB3, GGT1, ABCB11, SERPINA1, CYP2E1, RBP4
45alanine459.2RETN, GPT, PNPLA3, F2, HFE, RBP4
46cholesterol45 29 24 1112.1SERPINA1, ABCB11, HFE, RBP4, GGT1, SLC17A5
47serine459.0SERPINA3, SERPINA1, GGT1, RBP4, PDHX, PNPLA3
48glucose459.0ABCB11, RETN, HFE, PDHX, RBP4, GGT1
49testosterone45 61 24 1112.0CYP2E1, RETN, HFE, RBP4, SLC17A5, GGT1
50lipid458.9PNPLA3, SLC17A5, SERPINA3, GGT1, RBP4, HFE

GO Terms for genes affiliated with Liver Disease

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Sources:
16Gene Ontology
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Cellular components related to Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700629.2GGT1, RBP4, SERPINA3, SERPINB3, SERPINA1, GPT

Biological processes related to Liver Disease according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1maintenance of gastrointestinal epitheliumGO:03027710.2RBP4, SERPINA3
2acute-phase responseGO:00695310.2SERPINA3, SERPINA1, F2
3regulation of acetyl-CoA biosynthetic process from pyruvateGO:01051010.2PDHX, DLAT
4pyruvate metabolic processGO:00609010.2DLAT, PDHX
5regulation of proteolysisGO:03016210.2SERPINA1, SERPINB3, SERPINA3
6negative regulation of endopeptidase activityGO:01095110.1SERPINA3, SERPINB3, SERPINA1
7negative regulation of proteolysisGO:04586110.0SERPINB3, F2
8bile acid biosynthetic processGO:0066999.9HSD3B7, ABCB11
9small molecule metabolic processGO:0442819.3GGT1, ABCB11, CYP2E1, PNPLA3, GPT, HSD3B7

Molecular functions related to Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00486710.0SERPINA3, SERPINB3, SERPINA1

Products for genes affiliated with Liver Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Liver Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet