MCID: LVR013
MIFTS: 70

Liver Disease malady

Liver diseases category

Summaries for Liver Disease

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32MalaCards
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MalaCards: Liver Disease, also known as liver disorder in pregnancy, is related to fatty liver disease and hepatitis. An important gene associated with Liver Disease is SERPINA1 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1), and among its related pathways is Selenium Pathway. The drugs alglucerase and imiglucerase and the compounds lipid and creatinine have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and bone, and related mouse phenotypes are homeostasis/metabolism and liver/biliary system.

Aliases & Classifications for Liver Disease

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Sources:
8Disease Ontology, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Aliases & Descriptions:

liver disease 8 30
liver disorder in pregnancy 8 60
liver disorder in pregnancy, unspecified as to episode of care 8
liver disorder in pregnancy, with delivery 8
liver disorder in pregnancy unspecified 8
liver disorder in pregnancy - delivered 8
liver disorder in pregnancy nos 8
unspecified disorder of liver 8
liver disorder antepartum 8
disease of the liver 8
liver disorder nos 8
disorder of liver 8
disease of liver 8
hepatic disorder 8
liver disorder 8
liver diseases 60


External Ids:

Disease Ontology8 DOID:409
MeSH34 D008107
ICD9CM27 573.9
NCIt39 C3196

Related Diseases for Liver Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Liver Disease family:

Acute Liver Failure

Diseases related to Liver Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 501)
idRelated DiseaseScoreTop Affiliating Genes
1fatty liver disease31.9CYP2E1, SLC17A5, ADIPOQ
2hepatitis31.6GPT, SLC17A5
3hepatitis c31.2HFE, CYP2E1, GPT, F2, SLC17A5, KRT18
4obesity31.2HFE, CYP2E1, GPT, SLC17A5, GGT1, ADIPOQ
5hepatocellular carcinoma31.1HFE, CD14, CYP2E1, DLAT, GPT, F2
6alcoholic hepatitis31.0F2, CYP2E1
7hepatitis a31.0F2
8liver cirrhosis31.0ADIPOQ, SERPINA1, GGT1, KRT18, SLC17A5, F2
9hepatitis b31.0GGT1, SLC17A5, F2, GPT
10hypertension30.8F2, GGT1
11hemochromatosis30.7SERPINA1, HFE
12cystic fibrosis30.7ABCB11, KRT18, SERPINA1, SERPINA3
13portal hypertension30.7GPT, F2, SLC17A5, GGT1
14viral hepatitis30.6SLC17A5, F2, GPT, CD14, HFE, KRT18
15alcoholic liver cirrhosis30.6HFE, CYP2E1, GPT, F2, SLC17A5, GGT1
16cholestasis30.6SLC17A5, F2, ABCB11, GPT, HSD3B7, GGT1
17diabetes mellitus30.6HFE, CD14, CYP2E1, GPT, GGT1, SERPINA1
18atherosclerosis30.5CD14, GGT1, ADIPOQ
19alpha 1-antitrypsin deficiency30.5SERPINA3, SERPINA1
20acute liver failure30.5SLC17A5, F2, GPT
21galactosemia30.5GPT, F2, SLC17A5, GGT1, ADIPOQ
22autoimmune hepatitis30.5SEPSECS
23thrombocytopenia30.5SLC17A5, F2, GPT, HFE
24primary biliary cirrhosis30.5DLAT, PDHX
25alcohol dependence30.4GGT1
26alcohol abuse30.4HFE, CYP2E1, GPT, SLC17A5, GGT1
27type 2 diabetes mellitus30.4GPT, SLC17A5, GGT1, ADIPOQ
28peritonitis30.4F2, CD14
29cholangitis30.3DLAT, GPT, SLC17A5, GGT1, SEPSECS
30intrahepatic cholestasis30.3GGT1, SLC17A5, ABCB11
31neonatal hemochromatosis30.3SLC17A5, GGT1
32cryoglobulinemia30.3SLC17A5
33cholelithiasis30.3GPT, ABCB11, GGT1
34sclerosing cholangitis30.3SEPSECS
35brain disease30.2GPT, F2, SLC17A5, SERPINA3
36wilson disease30.2HFE, GPT, SLC17A5
37obstructive jaundice30.2GPT, SLC17A5, GGT1
38porphyria cutanea tarda30.2HFE
39porphyria30.2HFE
40hepatitis e30.2GPT
41hepatic encephalopathy30.2GPT, F2, SLC17A5
42pancreatitis30.1SERPINA1, GGT1, SLC17A5, CYP2E1
43cholangiocarcinoma30.1KRT18, GGT1
44colorectal cancer30.0CD14, CYP2E1, KRT18, SERPINA1
45leukemia30.0HFE, CD14, CYP2E1, ABCB11, SERPINA3
46siderosis30.0GPT, HFE
47cholestasis, progressive familial intrahepatic 130.0GGT1, ABCB11
48celiac disease30.0HFE
49polycystic ovary syndrome30.0ADIPOQ
50disseminated intravascular coagulation30.0F2, CD14

Graphical network of the top 20 diseases related to Liver Disease:



Diseases related to liver disease

Clinical Features for Liver Disease

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Drugs & Therapeutics for Liver Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Liver Disease

Drug clinical trials:

Search ClinicalTrials for Liver Disease

Search NIH Clinical Center for Liver Disease

Search CenterWatch for Liver Disease

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Liver Disease cell therapies at LifeMap Discovery.

Genetic Tests for Liver Disease

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Anatomical Context for Liver Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Liver Disease:

32
Liver, Kidney, Bone, Testes, Bone marrow, Spleen, Endothelial, Monocytes, Brain, Heart, Lung, T cells, Thyroid, Skin, B cells, Pituitary, Colon, Pancreas, Adipocyte, Fetal liver, Skeletal muscle, Prostate, Lymph node, Ovary, Breast, Eye, Placenta, Whole blood, Thymus, Tonsil, Appendix

Animal Models for Liver Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Liver Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.2PRKCSH, HFE, CD14, CYP2E1, ABCB11, F2
2MP:000537011.4ADIPOQ, HSD3B7, PRKCSH, HFE, CYP2E1, ABCB11

Publications for Liver Disease

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Sources:
50PubMed
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Articles related to Liver Disease:

(show top 50)    (show all 3767)
idTitleAuthorsYear
1
A case-control study on the effect of metabolic gene polymorphisms, nutrition, and their interaction on the risk of non-alcoholic fatty liver disease. (24402518)
2014
2
Review of treatment options for nonalcoholic fatty liver disease. (24266914)
2014
3
Orthotopic liver transplantation in polycystic liver disease]. (23453022)
2013
4
PNPLA3 I148M polymorphism and progressive liver disease. (24222941)
2013
5
Celiac disease hidden by cryptogenic hypertransaminasemia mistaken for fatty liver. (24020715)
2013
6
Fibrosis in non-alcoholic fatty liver disease: correlation with simple blood indices and association with tumor necrosis factor-alpha polymorphisms. (23923372)
2013
7
Hypovitaminosis D is associated with increased whole body fat mass and greater severity of non-alcoholic fatty liver disease. (24118743)
2013
8
Morphological and metabolic determinants of nonalcoholic fatty liver disease in obese youth: a pilot study. (23497552)
2013
9
The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis. (23743495)
2013
10
Treatment of non-alcoholic fatty liver disease. (24251709)
2013
11
SERPINB3 expression on B-cell surface in autoimmune diseases and hepatitis C virus-related chronic liver infection. (22829702)
2012
12
Metabolic disorders, non-alcoholic fatty liver disease and major liver resection: an underestimated perioperative risk. (23054903)
2012
13
Epicardial adipose tissue relating to anthropometrics, metabolic derangements and fatty liver disease independently contributes to serum high-sensitivity C-reactive protein beyond body fat composition: a study validated with computed tomography. (22014839)
2012
14
Measurement of the coronary flow velocity reserve in patients with non-alcoholic fatty liver disease. (23794311)
2012
15
IgM-linked SerpinB3 and SerpinB4 in sera of patients with chronic liver disease. (22808225)
2012
16
PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence. (21745286)
2011
17
Serum ferritin levels are associated with vascular damage in patients with nonalcoholic fatty liver disease. (20392616)
2011
18
Genetic variants of the bile salt export pump: inducers and modifiers of liver diseases. (21691112)
2011
19
Hyperuricemia is associated with histological liver damage in patients with non-alcoholic fatty liver disease. (21790685)
2011
20
Noncirrhotic human nonalcoholic fatty liver disease induces portal hypertension in relation to the histological degree of steatosis. (21389796)
2010
21
Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection. (20470843)
2010
22
What is behind the presence of anti-neutrophil cytoplasmatic antibodies in chronic liver disease? (19453948)
2009
23
Prevalence of non-alcoholic fatty liver disease in children and relationship to metabolic syndrome, insulin resistance, and waist circumference. (19568858)
2009
24
Green neutrophilic inclusions in liver disease. (19734487)
2009
25
Serum procalcitonin and CRP levels in non-alcoholic fatty liver disease: a case control study. (19222849)
2009
26
The neck-liver axis. Madelung disease as further evidence for an impact of body fat distribution on hepatic histology. (18161705)
2008
27
Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. (18471524)
2008
28
The association between non-alcoholic fatty liver disease and insulin resistance in 20 obese children and adolescents. (17187615)
2007
29
Expression of PD-1, PD-L1, and PD-L2 in the liver in autoimmune liver diseases. (17311651)
2007
30
Demographic and clinicopathological characteristics of nonalcoholic fatty liver disease in the East-Southeastern Anatolia regions in Turkey. (16340230)
2006
31
Polymorphisms of the glutathione S-transferases mu-1 (GSTM1) and theta-1 (GSTT1) and the risk of advanced alcoholic liver disease. (15932176)
2005
32
HIV infection does not affect the performance of noninvasive markers of fibrosis for the diagnosis of hepatitis C virus-related liver disease. (16284529)
2005
33
Dihydropyrimidine dehydrogenase and thymidylate synthase activities in hepatocellular carcinomas and in diseased livers. (13680162)
2003
34
S-Adenosylmethionine, cytokines, and alcoholic liver disease. (12163148)
2002
35
Serum biotinidase activity in children with chronic liver disease and its clinical significance. (11753166)
2002
36
The liver in hereditary hemorrhagic telangiectasia (Weber-Rendu-Osler disease). (10636073)
1999
37
Screening for cerebral aneurysm in patients with polycystic liver disease. (10624907)
1999
38
Pretransplant management and small bowel-liver transplantation in an infant with microvillus inclusion disease. (9740207)
1998
39
Hematological abnormalities and cholestatic liver disease in two patients with mevalonate kinase deficiency. (9714005)
1998
40
Suppression of elevated alanine aminotransferase activity in liver disease by vigabatrin. (9727187)
1998
41
Infectious mononucleosis presenting with cholestatic liver disease. (9499346)
1998
42
Prevalence of antibodies to hepatitis C virus and correlation with liver disease in renal transplant patients. (9057953)
1997
43
Genetic polymorphism of cytochrome P4502E1 and risk of alcoholic liver disease in Caucasians. (8747406)
1995
44
Mini-review: tumor necrosis factor (TNF) and TNF soluble receptors (TNF-sR) in liver disease and liver transplantation. (9127637)
1995
45
Hepatitis B virus markers, hepatitis D virus antigen and hepatitis C virus antibodies in Nigerian patients with chronic liver disease. (8904063)
1995
46
Growth factor and procollagen type I gene expression in human liver disease. (7806036)
1995
47
A simple method for evaluating prothrombin time in severe liver disease. (8135196)
1994
48
Rescue of mice homozygous for lethal albino deletions: implications for an animal model for the human liver disease tyrosinemia type 1. (8253377)
1993
49
Treatment of chronic liver disease with ursodeoxycholic acid. (2292332)
1990
50
The cerebral and peripheral uptake of ammonia in liver disease with an hypothesis for the mechanism of hepatic coma. (14367516)
1955

Genetic Variations for Liver Disease

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Expression for genes affiliated with Liver Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Liver Disease

Search GEO for disease gene expression data for Liver Disease.

Pathways for genes affiliated with Liver Disease

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Sources:
37NCBI BioSystems Database
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Pathways related to Liver Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0SERPINA3, GGT1, F2

Compounds for genes affiliated with Liver Disease

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Liver Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1lipid4412.8CYP2E1, HFE, GPT, ABCB11, CD14, ADIPOQ
2creatinine4412.6F2, CD14, CYP2E1, SERPINA3, SERPINA1, ADIPOQ
3cholesterol44 28 11 2415.5ABCB11, HFE, SLC17A5, SERPINA1, SERPINA3, ADIPOQ
4alanine4412.4KRT18, GGT1, HFE, SERPINA3, GPT, ADIPOQ
5ethanol44 49 11 2415.3GGT1, CYP2E1, SERPINA1, KRT18, SLC17A5, GPT
6fibrinogen4412.3SLC17A5, KRT18, SERPINA1, SERPINA3, ADIPOQ, F2
7lactate4412.3ADIPOQ, GGT1, KRT18, SLC17A5, F2, GPT
8aspartate4412.3ADIPOQ, GPT, F2, HFE, SLC17A5, KRT18
9nash4412.1KRT18, ADIPOQ, GGT1, SLC17A5, GPT, CYP2E1
10glucose4412.1KRT18, SERPINA1, SLC17A5, SERPINA3, CD14, ABCB11
11ascorbic acid44 2413.1GGT1, ADIPOQ, SERPINA1, KRT18, SLC17A5, CYP2E1
12iron44 2413.1KRT18, SLC17A5, GPT, HFE, GGT1, SERPINA1
13ursodeoxycholic acid44 11 2414.0F2, ABCB11, SLC17A5, GGT1, CYP2E1, GPT
14acetaminophen44 2 49 11 2415.9CYP2E1, GGT1, KRT18, SLC17A5, F2, GPT
15methotrexate44 49 1113.9ADIPOQ, F2, SLC17A5, GGT1, GPT, SERPINA3
16silymarin4411.8CYP2E1, F2, GGT1, GPT, SLC17A5
17rifampicin44 28 5913.7GPT, CYP2E1, ABCB11, SLC17A5, GGT1
18phenobarbital44 28 1113.7GGT1, GPT, SLC17A5, ABCB11, CYP2E1
19cyclosporin a44 28 5913.7SLC17A5, ABCB11, SEPSECS, CD14, F2, GPT
20verapamil44 49 28 11 2415.7CYP2E1, GGT1, ABCB11, SLC17A5, GPT
21urea44 11 2413.7SERPINA3, GGT1, KRT18, SLC17A5, GPT
22thyroxine44 2412.6SERPINA3, GPT, SLC17A5, GGT1, ADIPOQ
23tacrolimus44 49 1113.6SLC17A5, ABCB11, GPT, GGT1, ADIPOQ
24vitamin a44 11 2413.6CYP2E1, ADIPOQ, SERPINA3, SERPINA1
25aminopyrine4411.6F2, SLC17A5, GGT1, GPT
26sevoflurane44 1112.6SLC17A5, GPT, GGT1, CYP2E1
27antipyrine44 1112.6GGT1, SLC17A5, F2, CYP2E1
28pyruvate4411.6SLC17A5, GPT, DLAT, HFE, PDHX
29isoflurane44 1112.5GPT, SLC17A5, GGT1, CYP2E1
30rosuvastatin44 49 28 1114.5ADIPOQ, SLC17A5, GPT, ABCB11
31heparin44 28 11 2414.5CD14, ADIPOQ, SERPINA3, SERPINA1
32dexamethasone44 49 28 1114.5CYP2E1, KRT18, GGT1, ADIPOQ, CD14
33disulfiram44 59 1113.5GPT, CYP2E1, GGT1, SLC17A5
34bezafibrate44 28 1113.5GPT, SLC17A5, GGT1, ADIPOQ
35alpha lipoic acid4411.5SERPINA1, DLAT, GGT1, PDHX
36metformin44 49 1113.4GGT1, ADIPOQ, SLC17A5, GPT
37vitamin b124411.4SLC17A5, GPT, SERPINA3, GGT1
38betacarotene4411.4SLC17A5, SERPINA3, CYP2E1, GGT1
39lamivudine44 1112.4SLC17A5, ADIPOQ, F2
40hepaplastin4411.4F2, GPT, SLC17A5
41vinylchloride4411.3GGT1, SLC17A5, CYP2E1
42pioglitazone44 49 28 1114.3ADIPOQ, SLC17A5, GPT, GGT1
43glycocholate4411.3GPT, SLC17A5, ABCB11
44serine4411.3SERPINA3, ADIPOQ, SEPSECS, PDHX
45vitamin-e4411.2GGT1, SLC17A5, GPT, KRT18
46clozapine44 28 49 1114.1ADIPOQ, CYP2E1, GPT, GGT1
47uric acid44 2412.0HFE
48n acetylcysteine4411.0GPT, F2, SLC17A5, KRT18, GGT1
49nevirapine44 49 1113.0GGT1, SLC17A5, GPT
50isoniazid49 44 1113.0SLC17A5, CYP2E1, GPT

GO Terms for genes affiliated with Liver Disease

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16Gene Ontology
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Biological processes related to Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.4HSD3B7, PDHX, CYP2E1, DLAT, GPT, ABCB11
2acute-phase responseGO:00695311.0SERPINA3, SERPINA1, F2
3regulation of acetyl-CoA biosynthetic process from pyruvateGO:01051010.8DLAT, PDHX
4nitrogen compound metabolic processGO:00680710.7GPT, PRKCSH

Products for genes affiliated with Liver Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Liver Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet