MCID: LVR013
MIFTS: 69

Liver Disease malady

Gastrointestinal diseases, Liver diseases, Rare diseases categories

Summaries for Liver Disease

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34MalaCards
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MalaCards: Liver Disease, also known as liver disorder in pregnancy, is related to fatty liver disease and hepatitis. An important gene associated with Liver Disease is PRKCSH (protein kinase C substrate 80K-H), and among its related pathways are Eicosanoid Synthesis and Selenium Pathway. The drugs medium chain triglycerides and alglucerase and the compounds glycocholate and hepaplastin have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Aliases & Classifications for Liver Disease

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Sources:
9Disease Ontology, 32LifeMap Discoveryā„¢, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

liver disease 9 32
liver disorder in pregnancy 9 63
liver disorder in pregnancy, unspecified as to episode of care 9
liver disorder in pregnancy, with delivery 9
liver disorder in pregnancy unspecified 9
liver disorder in pregnancy - delivered 9
liver disorder in pregnancy nos 9
unspecified disorder of liver 9
liver disorder antepartum 9
disease of the liver 9
liver disorder nos 9
disorder of liver 9
hepatic disorder 9
disease of liver 9
liver disorder 9
liver diseases 63


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Disease Ontology9 DOID:409
ICD9CM28 573.9
MeSH36 D008107
NCIt41 C3196

Related Diseases for Liver Disease

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Liver Disease family:

Acute Liver Failure

Diseases related to Liver Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 544)
idRelated DiseaseScoreTop Affiliating Genes
1fatty liver disease32.0CYP2E1, SLC17A5
2hepatitis31.7SLC17A5, GPT
3obesity31.1CYP2E1, PNPLA3, GPT, RETN, HFE, RBP4
4hepatitis c31.1F2, CYP2E1, GPT, SERPINA1, HFE, RBP4
5insulin resistance31.1CYP2E1, GPT, RETN, HFE, RBP4, GGT1
6hepatitis b31.1F2, GPT, GGT1, SLC17A5
7hepatocellular carcinoma31.0F2, CYP2E1, GPT, SERPINA1, SERPINB3, HFE
8hypertension30.8F2, RETN, GGT1
9cystic fibrosis30.8RBP4, SERPINA3, SERPINA1, ABCB11
10portal hypertension30.7F2, GPT, RETN, GGT1, SLC17A5
11primary biliary cirrhosis30.6PDHX, DLAT
12alcoholic hepatitis30.6F2, CYP2E1
13galactosemia30.6F2, GPT, GGT1, SLC17A5
14autoimmune hepatitis30.5SLC17A5, GGT1, DLAT, GPT, F2
15thrombocytopenia30.5SLC17A5, HFE, GPT, F2
16cholestasis30.5HSD3B7, GPT, ABCB11, F2, SERPINA1, RBP4
17diabetes mellitus30.5CYP2E1, GPT, SERPINA1, RETN, HFE, RBP4
18viral hepatitis30.5F2, GPT, SERPINA1, HFE, GGT1, SLC17A5
19neonatal hemochromatosis30.5GGT1, SLC17A5
20intrahepatic cholestasis30.4ABCB11, GGT1, SLC17A5
21liver cirrhosis30.4SLC17A5, GGT1, RBP4, HFE, RETN, SERPINA3
22acute liver failure30.4SLC17A5, GPT, F2
23alcohol abuse30.4CYP2E1, GPT, HFE, GGT1, SLC17A5
24cholangitis30.4SLC17A5, GGT1, DLAT, GPT
25type 2 diabetes mellitus30.4GPT, RETN, RBP4, GGT1, SLC17A5
26cholelithiasis30.4ABCB11, GPT, GGT1
27obstructive jaundice30.3GPT, GGT1, SLC17A5
28wilson disease30.3GPT, HFE, SLC17A5
29primary sclerosing cholangitis30.3GPT, DLAT, GGT1
30hepatic encephalopathy30.3SLC17A5, GPT, F2
31hepatitis a30.2F2
32coronary artery disease30.2GGT1, HFE, RETN
33emphysema due to aat deficiency30.2SERPINA1, SERPINA3
34pancreatitis30.2CYP2E1, SERPINA1, GGT1, SLC17A5
35hepatitis e30.1GPT
36siderosis30.1HFE, GPT
37splenomegaly30.1SLC17A5, GPT
38alcoholic liver cirrhosis30.0F2, CYP2E1, GPT, HFE, GGT1, SLC17A5
39hypercholesterolemia30.0SLC17A5, GGT1, RBP4, RETN, GPT
40pyridoxine deficiency30.0GPT, SLC17A5
41cholestasis, progressive familial intrahepatic 130.0ABCB11, GGT1
42biliary atresia30.0GGT1, GPT
43glucose intolerance29.9GPT, RETN, RBP4
44panniculitis29.8SERPINA1
45opisthorchiasis29.8GGT1
46primary hyperoxaluria29.7RBP4, HFE, RETN, SERPINA1, CYP2E1
47adenocarcinoma29.7ABCB11, CYP2E1, SERPINA1, SERPINB3, SERPINA3, GGT1
48substance abuse29.6CYP2E1, GGT1
49polycystic liver disease10.9
50hepatitis c virus10.7

Graphical network of the top 20 diseases related to Liver Disease:



Diseases related to liver disease

Symptoms for Liver Disease

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Drugs & Therapeutics for Liver Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Liver Disease

Drug clinical trials:

Search ClinicalTrials for Liver Disease

Search NIH Clinical Center for Liver Disease

Search CenterWatch for Liver Disease

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Liver Disease cell therapies at LifeMap Discovery.

Genetic Tests for Liver Disease

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Anatomical Context for Liver Disease

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Sources:
34MalaCards
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MalaCards organs/tissues related to Liver Disease:

34
Liver, Bone, Testes, Kidney, Monocytes, Endothelial, T cells, Bone marrow, Heart, Brain, Adipocyte, Lung, Thyroid, Pituitary, Prostate, B cells, Skin, Fetal liver, Skeletal muscle, Ovary, Placenta, Breast, Colon, Pancreas, Whole blood, Spleen

Animal Models for Liver Disease or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Liver Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.5CYP2E1, HSD3B7, PRKCSH, RETN, HFE, ABCB11
2MP:00053768.2SLC17A5, F2, ABCB11, CYP2E1, PNPLA3, HSD3B7

Publications for Liver Disease

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Sources:
53PubMed
See all sources

Articles related to Liver Disease:

(show top 50)    (show all 3073)
idTitleAuthorsYear
1
Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor I' activation. (23605066)
2013
2
Liver transplantation for alcoholic liver disease: a retrospective analysis of recidivism, survival and risk factors predisposing to alcohol relapse. (24261021)
2013
3
Hepatitis and liver disease knowledge and preventive practices among health workers in Mexico: a cross-sectional study. (24097058)
2013
4
Pediatric non-alcoholic fatty liver disease: an increasing public health issue. (24068459)
2013
5
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. (22902550)
2013
6
IL28B polymorphisms are associated with severity ofA liver disease in human immunodeficiency virus (HIV) patients coinfected with hepatitis C virus. (23103287)
2013
7
Simple noninvasive systems predict long-term outcomes of patients with nonalcoholic fatty liver disease. (23860502)
2013
8
Oral probiotic microcapsule formulation ameliorates non-alcoholic fatty liver disease in Bio F1B Golden Syrian hamsters. (23554890)
2013
9
Prevalence of restless legs syndrome in Japanese patients with chronic liver disease. (22672613)
2012
10
The Seroconversion Rate of Hepatitis A Virus Vaccination among Patients with Hepatitis B Virus-Related Chronic Liver Disease in Korea. (21814604)
2011
11
Mammary duct ectasia in a man with liver disease, end stage renal failure, and adjacent arteriovenous fistula. (22470751)
2010
12
Usefulness of non-invasive markers for predicting significant fibrosis in patients with chronic liver disease. (20052350)
2010
13
Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study. (20825652)
2010
14
Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. (19523535)
2009
15
Prevalence of subclinical vitamin K deficiency in cholestatic liver disease. (19502999)
2009
16
Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease. (18713296)
2009
17
Serum adipokine levels in chronic liver diseases: association of resistin levels with fibrosis severity. (18609175)
2008
18
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. (18242210)
2008
19
Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? (17482764)
2007
20
The prevalence of peripheral iron overload and the presence of HFE gene (H63D) mutation among the Korean patients with nonalcoholic fatty liver disease]. (17585191)
2007
21
Serum C-reactive protein and liver disease in patients with melioidosis. (17262186)
2007
22
Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3',5'-cyclic monophosphate. (17383431)
2007
23
Methylenetetrahydrofolate reductase C677T mutation and nonalcoholic fatty liver disease. (17356914)
2007
24
Non-invasive markers to predict the liver fibrosis in non-alcoholic fatty liver disease. (16911470)
2006
25
Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. (16618517)
2006
26
Expression of epithelial cellular adhesion molecule (Ep-CAM) in chronic (necro-)inflammatory liver diseases and hepatocellular carcinoma. (16364680)
2006
27
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. (16799979)
2006
28
Nonalcoholic fatty liver disease in India--is it different? (17542290)
2006
29
The serum level of certain aminoacids in chronic liver diseases associated with impaired oral glucose tolerance. (17236290)
2006
30
The role of PPAR alpha in the pathogenesis of fatty liver disease]. (16174475)
2005
31
Hepatorenal syndrome: a dreaded complication of end-stage liver disease. (15667508)
2005
32
Laparoscopic left lateral sectorectomy for polycystic liver disease. (12962449)
2003
33
Plasma P-selectin levels are elevated in patients with chronic liver disease. (12945872)
2003
34
C282Y and H63D mutations of HFE gene in patients with advanced alcoholic liver disease. (11469076)
2001
35
A useful ELISA system for human liver-type arginase, and its utility in diagnosis of liver diseases. (11676974)
2001
36
How is the liver primed or sensitized for alcoholic liver disease? (11391068)
2001
37
Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases. (11685552)
2001
38
Oxidative stress and antioxidant defense in alcoholic liver disease and chronic hepatitis C]. (10962902)
2000
39
Circulating intercellular adhesion molecule-1 in chronic liver disease and hepatocellular carcinoma. (10462824)
1999
40
Serum IgA antibodies to human gut luminal aspirates and human liver in alcoholic liver disease. (9802516)
1998
41
Hepatocellular carcinoma associated with alcoholic liver disease: a clinicopathological study and genetic polymorphism of aldehyde dehydrogenase 2. (8986242)
1996
42
Carbohydrate-deficient transferrin in alcohol and nonalcohol abusers with liver disease. (8749821)
1995
43
Liver transplantation for end-stage liver disease associated with alpha-1-antitrypsin deficiency in children: pretransplant natural history, timing and results of transplantation. (8201225)
1994
44
The prognosis of patients with alcoholic liver disease. An international randomized, placebo-controlled trial on the effect of malotilate on survival. (8051381)
1994
45
Detection of autoantibodies against M2, LKM-1, and SLA in liver diseases by standardized uniform ELISA-techniques. (7807283)
1994
46
Genotypes of ALDH2 related to liver and pulmonary diseases and other genetic factors related to alcoholic liver disease. (7695791)
1994
47
Lecithin-cholesterol acyltransferase and lipid transfer protein activities in liver disease. (8446043)
1993
48
The role of cytokines in the pathophysiology of chronic liver diseases. (8123873)
1993
49
Minor role of hepatitis B virus in the causation of chronic liver disease in Somalia indicated by a case-control study. (1712517)
1991
50
The gallbladder in polycystic liver disease. (7054544)
1982

Variations for Liver Disease

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Expression for genes affiliated with Liver Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Liver Disease

Search GEO for disease gene expression data for Liver Disease.

Pathways for genes affiliated with Liver Disease

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG
See all sources

Pathways related to Liver Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
aspirin triggered resolvin E biosynthesis39
10.0PNPLA3, GGT1
2
Show member pathways
thioredoxin pathway39
9.9GGT1, SERPINA3, F2
3
Show member pathways
9.1GPT, CYP2E1, PNPLA3, HSD3B7, PDHX, DLAT

Compounds for genes affiliated with Liver Disease

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Liver Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1glycocholate4610.3GPT, SLC17A5, ABCB11
2hepaplastin4610.3F2, SLC17A5, GPT
3vinylchloride4610.2GGT1, CYP2E1, SLC17A5
4sevoflurane52 46 1212.1GGT1, CYP2E1, SLC17A5, GPT
5aminopyrine4610.1SLC17A5, GGT1, GPT, F2
6alpha lipoic acid4610.1SERPINA1, PDHX, DLAT, GGT1
7isoflurane52 46 1212.1SLC17A5, GGT1, CYP2E1, GPT
8antipyrine46 1211.1CYP2E1, SLC17A5, GGT1, F2
9lutein4610.0SERPINA3, RBP4, GGT1
10disulfiram46 52 62 1213.0SLC17A5, CYP2E1, GPT, GGT1
11vitamin b124610.0GGT1, SERPINA3, SLC17A5, GPT
12phosphorus4610.0SLC17A5, RBP4, GGT1, GPT
13rifampicin46 30 6212.0CYP2E1, ABCB11, GPT, GGT1, SLC17A5
14pyruvate4610.0DLAT, SLC17A5, PDHX, HFE, GPT
15phenobarbital46 30 52 1213.0GGT1, GPT, SLC17A5, CYP2E1, ABCB11
16nevirapine46 52 1211.9GGT1, GPT, SLC17A5
17betacarotene469.9SLC17A5, CYP2E1, GGT1, RBP4, SERPINA3
18metformin46 52 1211.9GGT1, RETN, SLC17A5, GPT
19verapamil46 30 52 25 1213.9ABCB11, SLC17A5, CYP2E1, GPT, GGT1
20silymarin469.9SLC17A5, GPT, GGT1, F2, CYP2E1
21acetaminophen46 3 52 25 1213.9F2, CYP2E1, GPT, GGT1, SLC17A5
22vitamin-e469.9RBP4, SLC17A5, GGT1, GPT
23isoniazid46 52 1211.9GPT, CYP2E1, SLC17A5
24pioglitazone30 46 52 1212.9RETN, RBP4, SLC17A5, GGT1, GPT
25fibrinogen469.8GPT, SERPINA1, SERPINA3, RETN, SLC17A5, F2
26ursodeoxycholic acid46 25 1211.8SLC17A5, GGT1, ABCB11, F2, CYP2E1, GPT
27phospholipid469.8RBP4, PNPLA3, ABCB11, SLC17A5, F2, SERPINA1
28methotrexate52 46 1211.8SLC17A5, GGT1, SERPINA3, GPT, F2
29nash469.8CYP2E1, GPT, RETN, HFE, SLC17A5, GGT1
30ethanol46 52 25 1212.8GGT1, SLC17A5, GPT, SERPINA1, HFE, CYP2E1
31urea46 25 1211.8GPT, RETN, RBP4, SLC17A5, GGT1, SERPINA3
32thyroxine46 2510.7SLC17A5, GPT, SERPINA3, RETN, GGT1, RBP4
33ascorbic acid46 2510.7SLC17A5, GGT1, HFE, RBP4, SERPINA1, CYP2E1
34uric acid46 2510.7SLC17A5, GGT1, RBP4, HFE, RETN, GPT
35valproic acid46 52 25 1212.7GGT1, SLC17A5, CYP2E1, GPT
36tamoxifen46 52 30 1212.7SLC17A5, CYP2E1, GGT1, ABCB11, F2
37iron46 2510.6GGT1, SLC17A5, RBP4, SERPINA3, SERPINA1, GPT
38heparin46 30 25 1212.6SLC17A5, F2, PNPLA3, SERPINA1, GGT1, SERPINA3
39lactate469.5GGT1, SLC17A5, F2, GPT, RBP4, CYP2E1
40vitamin a46 25 1211.5GGT1, SERPINA1, CYP2E1, SERPINA3, SLC17A5, RETN
41aspartate469.5RBP4, HFE, GPT, F2, GGT1, SLC17A5
42estrogen469.4RBP4, HFE, F2, ABCB11, SERPINA1, SERPINA3
43creatinine469.2GPT, SERPINA1, SLC17A5, GGT1, RBP4, RETN
44cysteine469.2SERPINB3, GGT1, ABCB11, SERPINA1, CYP2E1, RBP4
45alanine469.2RETN, GPT, PNPLA3, F2, HFE, RBP4
46cholesterol46 30 25 1212.1SERPINA1, ABCB11, HFE, RBP4, GGT1, SLC17A5
47serine469.0SERPINA3, SERPINA1, GGT1, RBP4, PDHX, PNPLA3
48glucose469.0ABCB11, RETN, HFE, PDHX, RBP4, GGT1
49testosterone46 62 25 1212.0CYP2E1, RETN, HFE, RBP4, SLC17A5, GGT1
50lipid468.9PNPLA3, SLC17A5, SERPINA3, GGT1, RBP4, HFE

GO Terms for genes affiliated with Liver Disease

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Sources:
17Gene Ontology
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Cellular components related to Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700629.2GGT1, RBP4, SERPINA3, SERPINB3, SERPINA1, GPT

Biological processes related to Liver Disease according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1maintenance of gastrointestinal epitheliumGO:03027710.2RBP4, SERPINA3
2acute-phase responseGO:00695310.2SERPINA3, SERPINA1, F2
3regulation of acetyl-CoA biosynthetic process from pyruvateGO:01051010.2PDHX, DLAT
4pyruvate metabolic processGO:00609010.2DLAT, PDHX
5regulation of proteolysisGO:03016210.2SERPINA1, SERPINB3, SERPINA3
6negative regulation of endopeptidase activityGO:01095110.1SERPINA3, SERPINB3, SERPINA1
7negative regulation of proteolysisGO:04586110.0SERPINB3, F2
8bile acid biosynthetic processGO:0066999.9HSD3B7, ABCB11
9small molecule metabolic processGO:0442819.3GGT1, ABCB11, CYP2E1, PNPLA3, GPT, HSD3B7

Molecular functions related to Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00486710.0SERPINA3, SERPINB3, SERPINA1

Products for genes affiliated with Liver Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Liver Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet