Liver Disease malady

MalaCards: Liver Disease, also known as liver disorder in pregnancy, is related to carcinoma and hepatocellular carcinoma. An important gene associated with Liver Disease is NAFLD2 (Fatty liver disease, nonalcoholic, susceptibility to, 2), and among its related pathways are ILK Signaling and Autoimmune thyroid disease. The drugs mct and alglucerase and the compounds glucose and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and brain, and related mouse phenotypes are immune system and mortality/aging.

Aliases & Descriptions:

liver disease 6 liver disorder in pregnancy 6 43 liver disorder in pregnancy, unspecified as to episode of care 6 liver disorder in pregnancy unspecified (disorder) 6 liver disorder in pregnancy - delivered (disorder) 6 liver disorder in pregnancy nos (disorder) 6 liver disorder in pregnancy, with delivery 6 liver disorder in pregnancy - delivered 6 liver disorder in pregnancy (disorder) 6 disease of the liver (disorder) 6 liver disorder nos (disorder) 6

unspecified disorder of liver 6 disorder of liver (disorder) 6 liver disorder antepartum 6 liver disorder nos 6 disease of liver 6 hepatic disorder 6 hepatic failure 7 liver disorder 6 liver diseases 43 liver failure 43

Diseases related to liver disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 996)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	109.2	PIK3C2A, PI3, KLF6, NCAM1, PDCD1, PDCD1LG2
2	hepatocellular carcinoma	86.9	KLF6, NCAM1, PDCD1, PDCD1LG2, RELA, CNR1
3	prostatitis	82.2	PIK3C2A, KLF6, NCAM1, PDCD1, RELA, RETN
4	leukemia	77.4	PIK3C2A, KLF6, NCAM1, PDCD1, PDCD1LG2, PDE4B
5	fibrosis	76.5	PI3, KLF6, RELA, REN, RETN, CNR1
6	cholesterol	74.7	PIK3C2A, RELA, REN, RETN, CNR1, CNR2
7	atherosclerosis	72.7	PIK3C2A, PI3, PDCD1, REN, RETN, SGCB
8	neuronitis	72.3	PIK3C2A, KLF6, NCAM1, PDE4B, RELA, REN
9	obesity	71.4	PIK3C2A, RELA, REN, RETN, CNR1, CNR2
10	diabetes mellitus	70.3	PIK3C2A, PI3, PDCD1, PDCD1LG2, REN, RETN
11	hypertension	69.4	PIK3C2A, KLF6, NCAM1, REN, RETN, SGCB
12	insulin resistance	65.7	RELA, REN, RETN, CNR1, VWF, GCKR
13	thyroiditis	65.3	PIK3C2A, NCAM1, RELA, REN, RETN, CNR2
14	myocardial infarction	61.3	PIK3C2A, PI3, PDCD1, REN, RETN, SGCB
15	cerebritis	60.3	PIK3C2A, KLF6, NCAM1, RELA, REN, SGCB
16	gastric cancer	58.6	KLF6, RELA, RETN, VWF, VTN, PCNA
17	esophagitis	58.3	PIK3C2A, KLF6, NCAM1, PDCD1LG2, RELA, REXO1L1
18	cystic fibrosis	58.3	PI3, REN, VWF, PCNA, GCLC, GC
19	fatty liver disease	58.0	RETN, CNR1, RBP4, SERPINE1, NAMPT, LIPC
20	malaria	54.6	PDE4B, REN, VWF, PCNA, GCLC, RBP4
21	liver cirrhosis	54.2	NCAM1, REN, RETN, CNR1, CNR2, VTN
22	ischemia	53.7	PIK3C2A, NCAM1, RELA, REN, RETN, SGCB
23	lupus erythematosus	53.4	PIK3C2A, PDCD1, PDCD1LG2, RETN, KIR2DL3, VWF
24	pulmonary disease	53.0	PI3, PDE4B, REN, RETN, VWF, PCNA
25	peritonitis	51.3	PIK3C2A, RELA, REN, KIR2DL3, VWF, VTN
26	anemia	51.2	NCAM1, PDCD1, RELA, REN, SGCB, VWF
27	pancreatitis	51.0	PIK3C2A, PI3, KLF6, NCAM1, PDCD1LG2, RELA
28	hepatitis	47.8	RBP4, SELP, SERPINA1, SEPSECS, VIPR1, XDH
29	type 2 diabetes mellitus	47.7	RETN, CNR1, VWF, GCKR, GCG, GC
30	hepatitis c	47.2	SERPINA1, VIPR1, LIPC, CISH, MX1, LDLR
31	morbid obesity	46.7	PIK3C2A, REN, RETN, CNR1, GCG, RBP4
32	cholestasis	46.4	CNR1, RDX, PCNA, GCG, RBP4, SERPINC1
33	blindness	46.4	PIK3C2A, REN, CNR1, VWF, RDH5, GCG
34	gonococcal synovitis	45.4	PI3, NCAM1, PDCD1, RELA, RETN, CNR1
35	alcoholism	45.3	CNR1, LBR, CFTR, GSR, IL1RN, MAOA
36	viral hepatitis	45.2	PCNA, SERPINC1, SERPINA1, SEPSECS, SERPINA3, MYB
37	essential hypertension	44.9	REN, RETN, VWF, SELE, SELP, SERPINC1
38	endometriosis	44.7	RELA, KIR2DL3, VTN, PCNA, GC, SERPINC1
39	squamous cell carcinoma	44.7	PI3, RELA, SGCB, VTN, RDX, PCNA
40	thrombosis	43.8	PIK3C2A, REN, RETN, VWF, VTN, PCNA
41	homocysteine	43.5	PIK3C2A, RELA, REN, RETN, VWF, PCNA
42	nonalcoholic steatohepatitis	43.3	RETN, PCNA, SERPINE1, LPA, BMP6, LEP
43	adenocarcinoma	42.6	PIK3C2A, KLF6, NCAM1, RELA, CNR1, VWF
44	liver cancer	42.1	SERPINA1, NAT2, VEGFA, MYC, BMP6, RARB
45	nasopharyngitis	41.7	KLF6, PDCD1, RELA, KIR2DL3, PCNA, NAT2
46	thrombocytopenia	40.9	PIK3C2A, NCAM1, VWF, SELE, SELP, SERPINC1
47	sepsis	40.6	PI3, RETN, VTN, RBP4, SELE, SELP
48	hepatitis b	40.5	PDCD1, MX1, CD58, CD274, CD40, ASGR2
49	iron overload	40.3	RBP4, SELP, SERPINA7, VDR, BMP6, UROD
50	retinol binding protein	40.3	RETN, RDH5, RBP4, NAMPT, LPA, MYC

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 alglucerase, imiglucerase, mct

MalaCards organs/tissues related to liver disease:

²²

MGI Mouse Phenotypes related to liver disease:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	INF	PDE4B, REN, SGCB, CNR2, VWF, RBPJ
2	mortality/aging	MP:0010768	INF	PIK3C2A, KLF6, NCAM1, PDCD1, PDCD1LG2, PDE4B
3	muscle phenotype	MP:0005369	INF	PDCD1, RELA, REN, SGCB, BTD, RBP4
4	digestive/alimentary phenotype	MP:0005381	INF	VWF, , RBPJ, VIPR1, VEGFA, VDR
5	integument phenotype	MP:0010771	INF	KLF6, RELA, CNR1, CNR2, BTD, RBPJ
6	hematopoietic system phenotype	MP:0005397	INF	KLF6, PDCD1, PDCD1LG2, PCNA, RBPJ, SERPINB2
7	embryogenesis phenotype	MP:0005380	INF	KLF6, GCLC, RBPJ, SERPINC1, MYC, MYB
8	cardiovascular system phenotype	MP:0005385	INF	KLF6, PDCD1, PDE4B, RELA, REN, SGCB
9	no phenotypic analysis	MP:0003012	INF	PDCD1LG2, CNR1, PCNA, SERPINA6, VEGFA, VCAM1
10	nervous system phenotype	MP:0003631	INF	PDCD1, PDE4B, RELA, REN, CNR1, VWF
11	renal/urinary system phenotype	MP:0005367	INF	PDCD1, REN, BTD, RBPJ, SELP, SERPINA6
12	liver/biliary system phenotype	MP:0005370	INF	KLF6, RETN, RDX, PCSK9, GCLC, SERPINC1
13	endocrine/exocrine gland phenotype	MP:0005379	INF	RBPJ, VIPR1, BMPR1A, RARG, , LDLR
14	limbs/digits/tail phenotype	MP:0005371	INF	RELA, VEGFA, VDR, BMP7, BMPR1A, RARA
15	adipose tissue phenotype	MP:0005375	INF	PIK3C2A, RETN, CNR1, SERPINE1, MYC, CLOCK
16	reproductive system phenotype	MP:0005389	INF	KLF6, REN, RBP4, VEGFA, VDR, BMP7
17	respiratory system phenotype	MP:0005388	INF	RBPJ, SELP, BMPR1A, BMPR2, ,
18	other phenotype	MP:0005395	12.5	CNR1, RARG, RARA, RARB, LEPR, LDLR
19	craniofacial phenotype	MP:0005382	INF	BMPR1A, RARG, , YBX1, , CFTR
20	cellular phenotype	MP:0005384	INF	KLF6, NCAM1, PDCD1, PDCD1LG2, PDE4B, RELA
21	growth/size phenotype	MP:0005378	INF	PIK3C2A, KLF6, RELA, REN, SGCB, CNR1
22	skeleton phenotype	MP:0005390	INF	RELA, CNR1, GC, VEGFA, VDR, MYC
23	vision/eye phenotype	MP:0005391	INF	NCAM1, PDCD1, RELA, RDH5, BTD, RBP4
24	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, PDCD1LG2, RELA, REN, RETN, CNR1
25	tumorigenesis	MP:0002006	INF	PDCD1LG2, RBPJ, SERPINE1, MYC, BMPR1A, RARA
26	behavior/neurological phenotype	MP:0005386	INF	NCAM1, REN, CNR1, RDX, BTD, RBPJ
27	normal phenotype	MP:0002873	INF	RELA, REN, VTN, GCLC, RBP4, SELE
28	hearing/vestibular/ear phenotype	MP:0005377	INF	RDX, VDR, MYC, BMP7, BMPR1A, RARG

Articles related to liver disease:

(show top 50)    (show all 1550)

id	Title	Authors	Year	Affiliating Genes
1	Familial hypobetalipoproteinemia in a hospital survey : genetics, metabolism and non-alcoholic fatty liver disease. (21502677)	GutiAcrrez-Cirlos C.... Aguilar-Salinas C.A.	2011	PCSK9, APOB
2	Serum retinol-binding protein 4 in patients with nona lcoholic fatty liver disease: does it have a significant impact on pathogenesis ? (19820404)	Cengiz C.... Boyacioglu S.	2010	RBP4
3	Nuclear receptors, inflammation, and liver disease: i nsights for cholestatic and fatty liver diseases. (20200515)	Arrese M.... Karpen S.J.	2010	NR1H2
4	PNPLA3 variants specifically confer increased risk fo r histologic nonalcoholic fatty liver disease but not metabolic disease. (20648472)	Speliotes E.K.... Hirschhorn J.N.	2010	GGT1, ABO, CPN1
5	Serum apoptotic caspase activity in chronic hepatitis C and nonalcoholic Fatty liver disease. (19881359)	Papatheodoridis G.V.... Archimandritis A.J.	2010	KRT18
6	Serum prohepcidin levels in chronic hepatitis C, alco holic liver disease, and nonalcoholic fatty liver disease. (20924211)	Lee S.H.... Lee D.H.	2010	HAMP
7	Serum dipeptidyl peptidase-4 activity in insulin resi stant patients with non-alcoholic fatty liver disease: a novel liver disease bi omarker. (20805868)	Firneisz G.... Somogyi A.	2010	DPP4
8	Current status of liver disease in Korea: nonalcoholi c fatty liver disease. (20037278)	Park S.H.	2009	RBP4
9	Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. (19824078)	Abdelmalek M.F.... Lindor K.D.	2009	INS
10	Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease. (18926681)	Sookoian S.... Pirola C.J.	2008	ABCC2
11	Screening for liver disease in cystic fibrosis: analysis of clinical and genetic risk factors for its development. (19227414)	Fustik S.... Koceva S.	2008	CFTR
12	Serum retinol-binding protein 4 levels are elevated in non-alcoholic fatty liver disease. (17941908)	Seo J.A.... Kim S.G.	2008	GGT1, RBP4
13	Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance. (18270241)	Newton J.L.... Day C.P.	2008	INS
14	CLD (chronic liver diseases)-HbA1C as a suitable indicator for estimation of mean plasma glucose in patients with chronic liver diseases. (18513821)	Koga M.... Bando Y.	2008	ALB
15	Evaluation of blood oxidative stress-related parameters in alcoholic liver disease and non-alcoholic fatty liver disease. (18609067)	Das K.S.... Vasudevan D.M.	2008	SOD1
16	Comparative redox status in alcoholic liver disease a nd nonalcoholic fatty liver disease. (19669305)	Bhardwaj P.... Saraya A.	2008	SOD1
17	Nonalcoholic fatty liver disease as a risk factor of cardiovascular disease: relation of non-alcoholic fatty liver disease to carotid atherosclerosis (18367860)	Choi S.Y.... Lee H.S.	2008	SERPINE1, GGT1, GPT
18	Albumin-binding function is reduced in patients with decompensated cirrhosis and correlates inversely with severity of liver disease assessed by model for end-stage liver disease. (17301654)	Klammt S.... Schmidt R.	2007	ALB
19	Association between tumor necrosis factor-alpha gene polymorphism and insulin resistance in nonalcoholic fatty liver disease (16938178)	Huang J.... Zhou Y.J.	2006	TNF
20	Serum osteoprotegerin and RANKL levels in chronic alcoholic liver disease. (16476762)	GarcA-a-Valdecasas-Campelo E.... GA^mez-RodrA-guez M.d.e. .L.	2006	IGF1, TNF, IL6
21	Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance. (16394091)	Pagano C.... Vettor R.	2006	INS, RETN
22	Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease. (17032401)	Day C.P.	2006	CD14, BMP6
23	Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease. (16231364)	Musso G.... Pagano G.	2005	TNF, LEP, ADIPOQ
24	Increase in liver antioxidant enzyme activities in non-alcoholic fatty liver disease. (16162151)	Perlemuter G.... Buffet C.	2005	CAT
25	The RANKL/OPG system and bone mineral density in patients with chronic liver disease. (16143421)	Moschen A.R.... Tilg H.	2005	TNFRSF11B, TNFSF11
26	Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease. (16105135)	Gulsen M.... Dagalp K.	2005	CBS
27	Abnormal hepatocystin caused by truncating PRKCSH mutations leads to autosomal dominant polycystic liver disease. (15057895)	Drenth J.P.... Jansen J.B.	2004	PRKCSH
28	Hepatic stellate cells in hepatitis C patients: relationship with liver iron deposits and severity of liver disease. (14675249)	Martinelli A.L.... Zucoloto S.	2004	GFAP
29	Recent advances in alcoholic liver disease. IV. Dysregulated cytokine metabolism in alcoholic liver disease. (15331349)	McClain C.J.... Deaciuc I.	2004	TNF
30	Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies. (12724528)	Ku N.-O.... Omary M.B.	2003	KRT18, KRT8
31	Carbohydrate 19-9 antigen is not a marker of liver disease in patients with cystic fibrosis. (12705340)	Bettinardi N.... Colombo C.	2003	GPT
32	Ultrasound evaluation of liver disease in cystic fibr osis as part of an annual assessment clinic: a 9-year review. (12014933)	Williams S.M.... Lindsell D.R.	2002	SLC17A5
33	Concentrations of lipopolysaccharide-binding protein, bactericidal/permeability-increasing protein, soluble CD14 and plasma lipids in relation to endotoxaemia in patients with alcoholic liver disease. (11825862)	SchAofer C.... Bode C.	2002	LBP, BPI
34	The mannose binding lectin gene influences the severity of chronic liver disease in cystic fibrosis. (11333866)	Gabolde M.... Besmond C.	2001	CFTR, MBL2, LMAN1
35	MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM-1 in chronic inflammatory liver disease). (11343233)	Grant A.J.... Adams D.H.	2001	MADCAM1
36	Plasma antioxidant levels in chronic cholestatic liver diseases. (10735930)	Floreani A.... D'Odorico A.	2000	GGT1, ALPP
37	Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK) (10824890)	Lindgren S.... Wieslander J.	2000	PRTN3, BPI
38	Chronic liver disease and hepatitis C virus in Egyptian patients. (10430366)	El-Medany O.M.... Gad El-Hak N.	1999	REXO1L1
39	Soluble complement receptor type 1 (sCR1) in chronic liver diseases: serum levels at different stages of liver diseases. (9764610)	Di Bona D.... Brai M.	1998	CR1
40	Hepatic lobar differences in progression of chronic liver disease: correlation of asialoglycoprotein scintigraphy and hepatic functional reserve. (9096583)	Matsuzaki S.... Kim D.Y.	1997	F2, ALB
41	Hepatocellular carcinoma associated with alcoholic liver disease: a clinicopathological study and genetic polymorphism of aldehyde dehydrogenase 2. (8986242)	Ohhira M.... Kohgo Y.	1996	ALDH2
42	Prostaglandins in chronic liver diseases (8664600)	Loginov A.S.... Vysotskaia R.A.	1995	ADCY10
43	Hypothalamic-pituitary-testicular function in end-sta ge non-alcoholic liver disease before and after liver transplantation. (7586603)	Handelsman D.J.... McCaughan G.W.	1995	SHBG
44	Interleukin-8 in alcoholic liver disease. (7810274)	Bird G.	1994	TNF, IL6, IL8
45	Monosaccharide composition of haptoglobin in liver diseases and alcohol abuse: large changes in glycosylation associated with alcoholic liver disease. (7955423)	Mann A.C.... Turner G.A.	1994	HP
46	Abnormally fucosylated haptoglobin as a marker for alcoholic liver disease but not excessive alcohol consumption or non-alcoholic liver disease. (8306457)	Chambers W.... Turner G.A.	1993	HP
47	Atrial natriuretic factor and liver disease. (8444424)	Warner L.... Epstein M.	1993	NPPA
48	Plasma fibronectin in chronic liver diseases (8210624)	Soresi M.... Notarbartolo A.	1993	GGT1, APEH
49	Preliminary study of alpha-fetoprotein in nonmalignant liver diseases. A clinico-biochemical evaluation. (1378876)	Collazos J.... Ruibal A.	1992	AFP
50	Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease. (1750499)	Milani S.... Surrenti C.	1991	TGFB1, TGIF1

Genes related to liver disease according to GeneCards:

(show top 50)    (show all 666)

id	Symbol	Description	Score	GeneCards Section Context
1	NAFLD2	Fatty liver disease, nonalcoholic, susceptibility to, 2	11.0	Aliases & Descriptions
2	FLD1	Fatty liver disease 1, susceptiblity to	11.0	Aliases & Descriptions
3	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications, Summaries
4	PRKCSH	protein kinase C substrate 80K-H	11.0	Orthologs, Publications, Summaries
5	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications, Summaries
6	PCLD	polycystic liver disease	11.0	Aliases & Descriptions
7	HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	11.0	Summaries, Publications
8	DLAT	dihydrolipoamide S-acetyltransferase	11.0	Summaries, Publications
9	ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	11.0	Publications, Summaries
10	PDHX	pyruvate dehydrogenase complex, component X	11.0	Summaries
11	HFE	hemochromatosis	11.0	Publications
12	SEPSECS	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	11.0	Publications
13	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
14	GGT1	gamma-glutamyltransferase 1	11.0	Publications
15	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
16	KRT18	keratin 18	11.0	Publications
17	CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	11.0	Publications
18	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	11.0	Publications
19	F2	coagulation factor II (thrombin)	11.0	Publications
20	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
21	ALB	albumin	11.0	Publications
22	CD14	CD14 molecule	11.0	Publications
23	TF	transferrin	11.0	Publications
24	CP	ceruloplasmin (ferroxidase)	11.0	Publications
25	RETN	resistin	11.0	Publications
26	RBP4	retinol binding protein 4, plasma	11.0	Publications
27	LSL	Leptin, serum levels of	11.0	Publications
28	PEMT	phosphatidylethanolamine N-methyltransferase	11.0	Publications
29	AFP	alpha-fetoprotein	11.0	Publications
30	NR1H2	nuclear receptor subfamily 1, group H, member 2	11.0	Publications
31	ALPP	alkaline phosphatase, placental	11.0	Publications
32	PKD1	polycystic kidney disease 1 (autosomal dominant)	11.0	Publications
33	LBP	lipopolysaccharide binding protein	11.0	Publications
34	PPARA	peroxisome proliferator-activated receptor alpha	11.0	Publications
35	PPIG	peptidylprolyl isomerase G (cyclophilin G)	11.0	Publications
36	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0	Publications
37	CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	11.0	Publications
38	CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	11.0	Publications
39	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	11.0	Publications
40	DPP4	dipeptidyl-peptidase 4	11.0	Publications
41	TNF	tumor necrosis factor	11.0	Publications
42	SEC63	SEC63 homolog (S. cerevisiae)	11.0	Publications
43	THPO	thrombopoietin	11.0	Publications
44	ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	11.0	Publications
45	SPINK1	serine peptidase inhibitor, Kazal type 1	11.0	Publications
46	PKD2	polycystic kidney disease 2 (autosomal dominant)	11.0	Publications
47	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	11.0	Publications
48	MTTP	microsomal triglyceride transfer protein	11.0	Publications
49	CCL21	chemokine (C-C motif) ligand 21	11.0	Publications
50	ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	11.0	Publications

Pathways related to liver disease according to GeneDecks:

(show top 50)    (show all 122)

id	Pathway	Score	Top Affiliating Genes
1	ILK Signaling36	INF	BMP7, UTS2, JUN, CDH17, CDH1, ITGB1
2	Autoimmune thyroid disease20	INF	CD40LG, , CD40, , IL10, IL2
3	Toxoplasmosis20	INF	RELA, BCL2, CHUK, LDLR, CD40LG, CD40
4	Chagas disease (American trypanosomiasis)20	INF	RELA, SERPINE1, CHUK, JUN, FOS, IL10
5	NF-KappaB Family Pathway36	INF	RELA, BMP6, BMP7, UTS2, CHUK, FLT1
6	NFAT in Immune Response36	INF	BMP6, BMP7, UTS2, CHUK, JUN, CD79A
7	PEDF Induced Signaling36	INF	RELA, BMP6, BMP7, BCL2, CHUK, BAX
8	Pathways in cancer20	INF	RELA, VEGFA, MYC, RARA, RARB, RASSF1
9	Tec Kinases Signaling36	INF	BMP6, BMP7, BMPR1A, BMPR2, UTS2, BCL2
10	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	INF	VDR, BGLAP, JUN, FOS, IL1A, IL1B
11	Glucose / Energy Metabolism3	INF	, SCD, FOXA2, IRS1, IRS2, ARG1
12	Transcription Role of VDR in regulation of genes involved in osteoporosis10	INF	VDR, BGLAP, JUN, FOS, IL1A, IL1B
13	JAK-STAT Pathway36	INF	MYC, BMP6, BMP7, UTS2, BCL2, BAX
14	all-trans-Retinoic Acid Signaling in Brain36	INF	BMP6, BMP7, RARG, RARA, RARB, BCL2
15	RAR-Gamma-RXR-Alpha Degradation36	INF	BMP7, RARG, , IL11, IL15, IL2
16	Antioxidant Action of Vitamin-C36	INF	BMP6, BMP7, BMPR1A, BMPR2, UTS2, BCL2
17	Immune System38	INF	NCAM1, PDCD1, PDCD1LG2, KIR2DL3, VCAM1, LGALS3
18	PAK Pathway36	INF	BMP6, BMP7, UTS2, BCL2, BAX,
19	MAPK Family Pathway36	INF	BMP6, BMP7, UTS2, BCL2, CHUK, BAX
20	Metabolism of xenobiotics by cytochrome P45020	13.2	UGT1A1, UGT1A10, UGT1A4, UGT1A6, UGT1A7, UGT1A9
21	Drug metabolism - cytochrome P45020	13.1	UGT1A1, UGT1A10, UGT1A4, UGT1A6, UGT1A7, UGT1A9
22	Complement and coagulation cascades20	11.6	VWF, SERPINC1, SERPINA1, SERPINE1, CD46, FGA
23	Cytokine production by Th17 cells in CF (Mouse model)41	11.4	RELA, CHUK, LBP, CFTR, CD14, IL12B
24	Hematopoietic cell lineage20	11.4	CD36, CD14, CD34, CD44, ITGB3, MME
25	Blood Coagulation Signaling Pathways37	11.3	VWF, SERPINC1, SERPINB2, SERPINE1, GP9, F9
26	mTOR Pathway36	INF	BMP6, BMP7, UTS2, IRS1, INS, INSR
27	Adipocytokines & Insulin Signaling37	INF	RETN, RBP4, SERPINA12, NAMPT, LEP, FOS
28	JNK Pathway36	INF	BMP6, BMP7, UTS2, BCL2, BAX, JUN
29	Immune response MIF-mediated glucocorticoid regulation10	INF	RELA, VCAM1, CHUK, JUN, MMP1, FOS
30	Mitochondrial Apoptosis36	INF	BMP6, BMP7, UTS2, , BCL2, BAX
31	MAPK Signaling36	INF	MYC, BMP6, BMP7, UTS2, BCL2, CHUK
32	Apoptotic Pathways in Synovial Fibroblasts36	INF	BMP6, BMP7, UTS2, FLT1, FGF19, FGF2
33	Influenza A20	INF	RELA, MX1, JUN, GSK3B, IL12B, IL18
34	GPCR Pathway36	INF	BMP6, BMP7, UTS2, CHUK, JUN, FOS
35	Cytokine-cytokine receptor interaction20	INF	VEGFA, BMP7, BMPR1A, BMPR2, LEP, LEPR
36	Immune response_MIF-mediated glucocorticoid regulation41	INF	RELA, VCAM1, CHUK, JUN, MMP1, FOS
37	Renin-Angiotensin Pathway36	INF	REN, VCAM1, BMP6, BMP7, UTS2, CHUK
38	14-3-3 Induced Intracellular Signaling36	INF	BMP7, UTS2, JUN, FLT1, INSR, FGF19
39	Telomerase Components in Cell Signaling36	INF	MYC, BMP6, BMP7, UTS2, FLT1, FGF19
40	TGF-Beta Pathway36	INF	BMP6, BMP7, UTS2, BCL2, BAX, JUN
41	Selected targets of GCR-alpha10	INF	VIPR1, LEP, UCP3, CDKN1A, INS, INSR
42	Rheumatoid arthritis20	INF	VEGFA, JUN, , MMP1, MMP3, FOS
43	STAT3 Pathway36	INF	MYC, BMP6, BMP7, BMPR1A, BMPR2, BCL2
44	Rho Family GTPases36	INF	RDX, BMP6, BMP7, UTS2, BCL2, BAX
45	Akt Signaling36	INF	BMP7, BMPR1A, BMPR2, UTS2, CHUK,
46	Tuberculosis20	INF	RELA, VDR, , CLEC4M, BCL2, BAX
47	Phenytoin Pathway, Pharmacokinetics34	INF	UGT1A1, UGT1A4, UGT1A6, UGT1A9, PTGIS, CYP1A2
48	Measles20	INF	RELA, CLEC4M, CHUK, MX1, CD209, CD46
49	p53 Mediated Apoptosis36	INF	BMP6, BMP7, UTS2, , BCL2, BAX
50	NF-KappaB (p50-p65) Pathway36	INF	RELA, BMP6, BMP7, UTS2, CHUK, FLT1

Compounds related to liver disease according to GeneDecks:

(show top 50)    (show all 581)

id	Compound	Score	Top Affiliating Genes
1	glucose32	INF	, BTD, SERPINA12, VIPR1, LMAN1, BMP7
2	tamoxifen32 34 9 9	INF	VTN, PCNA, SELE, SERPINC1, SERPINA7, SERPINA6
3	atp32	INF	PIK3C2A, NCAM1, SGCB, VTN, LIPC, BLVRB
4	ionomycin32	INF	SERPINA3, CHUK, CD274, CD40, FOS, IL3
5	folate32	INF	VWF, RBP4, SELE, SERPINC1, SERPINA3, NAT2
6	aspirin32 34 18	INF	CNR1, VWF, VTN, PCNA, SELE, SELP
7	rosiglitazone32 9 18 9	INF	RETN, RBP4, SELE, SERPINE1, NAMPT,
8	valproate32	INF	UGT1A, MTHFR, XBP1, CD79A, CD40LG, GSK3B
9	fenofibrate32 9 9	INF	PIK3C2A, RETN, SELE, SELP, SERPINE1,
10	dithiothreitol32	INF	VWF, SERPINB2, , UGT1A1, MTTP, ATP8A1
11	neopterin32	INF	CHIT1, CHKB, MX1, LCN2, , B2M
12	cocaine32 9 9	INF	PIK3C2A, CNR1, , SELE, SELP, VCAM1
13	alpha lipoic acid32	INF	BTD, SERPINA1, VCAM1, BAX, MMP9, INS
14	latex32	INF	VWF, VTN, RBP4, BLZF1, LGALS3, CHKB
15	proline32	INF	SERPINA7, VIPR1, , LGALS3, MVK,
16	n-(4-hydroxyphenyl)retinamide32	INF	RBP4, MYC, BMP6, RARG, RARA, RARB
17	carbachol32 9 9	INF	, , CFTR, IL11, CCK, HSPG2
18	acetylcholine32 9 18 9	INF	PIK3C2A, NCAM1, SGCB, CNR1, VWF,
19	saquinavir32 9 9	14.4	UGT1A, UGT1A1, IRS1, ALB, CYP3A4, CYP2C19
20	dextran sulfate32	12.2	VTN, SELE, SELP, SERPINC1, LDLR, CETP
21	captopril32 42 9 9	15.2	REN, B2M, CD79A, MMP2, IL1A, APOA1
22	silver32	11.8	PCNA, SERPINA3, BLZF1, UCP2, CDKN2A, CD34
23	aprotinin32 9 9	13.8	VWF, SELP, SERPINC1, SERPINB2, MMP2, MMP9
24	n(g)-nitro-l-arginine methyl ester32	11.5	SERPINE1, UTS2, LEP, XDH, MMP2, FAS
25	ang ii32	INF	REN, VEGFA, LAP3, CD36, IL6ST, MAPK8
26	cholesterol ester32	INF	, LIPC, SCD, LDLR, LCAT, MTTP
27	1,25 dihydroxy vitamin d332	INF	GC, VDR, MYC, BMP6, RARA, BGLAP
28	cholesterol32 9 18 9	INF	PIK3C2A, REN, RETN, CNR2, VWF, VTN
29	infliximab32 9 9	INF	SELE, VEGFA, BGLAP, , MMP1, MMP3
30	progestin32	INF	SERPINC1, VEGFA, CDH1, INSR, APOA1, IGFBP1
31	desmopressin32 42 9 9	INF	REN, VWF, SELP, SERPINC1, SERPINE1, B2M
32	rofecoxib32 9 9	INF	SELP, BIRC5, MMP3, CYP1A2, CYP3A4, CYP2C8
33	thymidine32 18	INF	CNR2, PCNA, SERPINA1, VDR, MYC, MYB
34	phosphatidylserine32 9 9	INF	VWF, SELE, , BCL2, , ATP8A1
35	glibenclamide32 34	INF	SGCB, CNR1, , LIPC, LEP, CFTR
36	tbhq32	INF	GCLC, UGT1A, UGT1A6, JUN, FOS, GSR
37	propranolol32 34 9 18 9	INF	REN, UGT1A9, LDLR, MPO, , MME
38	bezafibrate32 9 9	INF	PIK3C2A, SERPINE1, , LIPC, CHKB, LDLR
39	budesonide32 42 9 9	INF	BGLAP, CD36, ANXA1, CCL11, CYP3A4,
40	uridine diphosphate32	INF	NAT2, UGT1A, UGT1A1, UGT1A10, UGT1A4, UGT1A6
41	daunorubicin32 9 9	INF	RELA, MYC, BIRC5, BCL2, BAX, XDH
42	l-nmma32	INF	SGCB, VCAM1, XDH, INSR, IL1RN, CCK
43	troglitazone32 42 9 9	INF	SELE, SERPINE1, VDR, VCAM1, BMP6, RARA
44	sodium32 18	INF	PIK3C2A, NCAM1, REN, RETN, SGCB, UTS2
45	clonidine32 9 9	INF	REN, BGLAP, LEP, FGF2, IL1RAPL2, IGFBP3
46	toremifene32 9 9	INF	FAS, ESR2, ERBB2, TNFRSF1B, SULT2A1, CYP1A1
47	pd 98,05932	INF	VTN, , GCLC, SERPINE1, VCAM1, MYC
48	rsai32	INF	NAT2, GSTM1, GSTT1, FGA, FAH, IGFBP1
49	dihydrotestosterone32 9 18 9	INF	SERPINA6, SERPINE1, VDR, BMP6, BGLAP, LEP
50	suberoylanilide hydroxamic acid32	INF	MYC, , BIRC5, BCL2, BAX, CDKN1A

Cellular components related to liver disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	INF	REN, VTN, PCSK9, , GC, BTD
2	extracellular region	GO:005576	INF	NCAM1, PDCD1LG2, RETN, VWF, VTN,
3	integral to plasma membrane	GO:005887	INF	SGCB, CNR1, CNR2, KIR2DL3, SELP, VIPR1
4	plasma membrane	GO:005886	INF	PIK3C2A, NCAM1, PDCD1, PDCD1LG2, CNR1, CNR2
5	membrane raft	GO:045121	11.5	SELE, CD79A, CD36, CD14, ITGB1, GSK3B
6	platelet alpha granule lumen	GO:031093	10.9	VWF, SERPINA1, SERPINE1, VEGFA, FN1, FGA
7	cytosol	GO:005829	INF	PIK3C2A, PDE4B, RELA, GCKR, GCLC, GC
8	cell surface	GO:009986	INF	NCAM1, PCSK9, VEGFA, VCAM1, BMPR2, RARA
9	external side of plasma membrane	GO:009897	INF	NCAM1, VWF, SELP, VCAM1, LDLR, B2M
10	cytoplasm	GO:005737	INF	PIK3C2A, KLF6, RELA, REXO1L1, SGCB, PCSK9

Biological processes related to liver disease according to GeneDecks:

(show all 47)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:008284	INF	VIPR1, NAMPT, VEGFA, MYC, RARA, BIRC5
2	transcription initiation from RNA polymerase II promoter	GO:006367	INF	RBPJ, SERPINE1, VDR, MYC, RARG, RARA
3	immune response	GO:006955	INF	PDCD1LG2, CNR2, KIR2DL3, VTN, VIPR1, BPI
4	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	KLF6, RELA, RBPJ, SERPINE1, VEGFA, VDR
5	positive regulation of ERK1 and ERK2 cascade	GO:070374	INF	, , CD44, MIF, FGF19, FGF2
6	response to drug	GO:042493	INF	REN, SERPINA7, MYC, UTS2, BGLAP, BCHE
7	oxidation-reduction process	GO:055114	INF	MPO, ALDH3A1, ALDH9A1, , TXN, DUOX1
8	angiogenesis	GO:001525	INF	SERPINE1, VEGFA, CEACAM1, JUN, , MMP2
9	negative regulation of apoptotic process	GO:043066	INF	RELA, , SERPINE1, VEGFA, MYC, BCL2
10	cytokine-mediated signaling pathway	GO:019221	INF	KLF6, NCAM1, RELA, VCAM1, MX1, B2M
11	response to estradiol stimulus	GO:032355	INF	GC, SERPINA1, VDR, RARA, , MMP9
12	anti-apoptosis	GO:006916	INF	RELA, GCLC, SERPINB2, BIRC5, BCL2, MPO
13	apoptotic process	GO:006915	INF	PDCD1, PCSK9, , BIRC5, BCL2,
14	positive regulation of apoptotic process	GO:043065	INF	CNR1, RARG, RARB, , BAX, ITGB1
15	positive regulation of angiogenesis	GO:045766	INF	SERPINE1, VEGFA, UTS2, , CD34, MMP9
16	lipid metabolic process	GO:006629	INF	, , CHKA, UGT2B7, LDLR, UCP3
17	cell-cell signaling	GO:007267	INF	NAMPT, CGB, , ISG15, INS, FGF21
18	small molecule metabolic process	GO:044281	INF	PIK3C2A, GCKR, , GCLC, GC, NAMPT
19	cellular lipid metabolic process	GO:044255	13.6	UGT1A9, CD36, FDFT1, APOA1, FABP1, FASN
20	cholesterol metabolic process	GO:008203	13.0	PCSK9, LIPC, LEP, LEPR, LDLR, LCAT
21	response to glucocorticoid stimulus	GO:051384	12.9	SERPINE1, BGLAP, BCHE, UCP3, LCAT, INSR
22	acute-phase response	GO:006953	12.3	SERPINA1, SERPINA3, LBP, CD163, FN1, ASS1
23	response to ethanol	GO:045471	11.9	CNR1, RBP4, BGLAP, BCL2, CDK1, MMP9
24	organ regeneration	GO:031100	11.8	UGT1A1, CDKN1A, CDK1, MKI67, APOH, ANGPT2
25	platelet degranulation	GO:002576	11.8	VWF, SELP, SERPINA1, SERPINE1, VEGFA, CD36
26	positive regulation of NF-kappaB transcription factor activity	GO:051092	11.8	RELA, CHUK, CD40, INS, IL1B, IL6
27	positive regulation of nitric oxide biosynthetic process	GO:045429	10.9	INS, INSR, IL1B, IFNG, ICAM1, HSP90AA1
28	positive regulation of inflammatory response	GO:050729	10.7	SERPINE1, IL12B, IL15, IL18, IL2, IL21
29	positive regulation of MAP kinase activity	GO:043406	10.5	VEGFA, CD40, FLT1, HTR2B, GH1, ERBB2
30	blood coagulation	GO:007596	INF	VWF, SELP, SERPINC1, SERPINB2, SERPINA1, SERPINE1
31	positive regulation of protein kinase B signaling cascade	GO:051897	INF	, INS, INSR, ANGPT1, CCL3, CCL21
32	xenobiotic metabolic process	GO:006805	INF	GCLC, NAT2, UGT1A1, UGT1A4, UGT1A6, UGT1A9
33	response to organic cyclic compound	GO:014070	INF	SELP, SERPINA1, UGT1A1, JUN, CDKN1A, CDK1
34	negative regulation of cell proliferation	GO:008285	INF	VDR, RARG, RARB, ATP8A2, JUN, CDKN1A
35	bile acid metabolic process	GO:008206	INF	LEP, ATP8B1, AMACR, ALB, HSD3B7, AKR1C4
36	platelet activation	GO:030168	INF	VWF, SELP, SERPINA1, SERPINE1, VEGFA,
37	response to activity	GO:014823	INF	BGLAP, UCP3, CDK1, ITGB1, INSR, IL10
38	aging	GO:007568	INF	CNR1, SERPINA7, VDR, VCAM1, UCP3, JUN
39	response to hypoxia	GO:001666	INF	SERPINA1, VEGFA, VCAM1, UTS2, BCL2, KCNA5
40	response to lipopolysaccharide	GO:032496	INF	CNR1, CNR2, SELE, SELP, SERPINA1, UGT1A1
41	inflammatory response	GO:006954	INF	RELA, CNR2, SELE, SELP, SERPINA3, BMP6
42	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	INF	VTN, VEGFA, CD36, , CD44, ITGB1
43	regulation of blood pressure	GO:008217	INF	REN, UTS2, LEP, CD34, CALCA, HMOX1
44	positive regulation of transcription, DNA-dependent	GO:045893	INF	KLF6, RELA, MYC, MYB, BMP7, BMPR1A
45	cellular response to lipopolysaccharide	GO:071222	INF	SERPINE1, LBP, CD36, CD14, ASS1, ARG1
46	cholesterol homeostasis	GO:042632	INF	PCSK9, LIPC, LDLR, LCAT, CETP, APOA1
47	signal transduction	GO:007165	INF	PDCD1, PDE4B, , NAMPT, VDR, RARA

Molecular functions related to liver disease according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	receptor binding	GO:005102	INF	REN, , SERPINE1, RARA, UTS2, KCNA5
2	identical protein binding	GO:042802	INF	, SUN2, TNF, TP53, ERBB2,
3	enzyme binding	GO:019899	12.3	ESR1, ESR2, HMOX1, TP53, PTEN, PTGS2
4	iron ion binding	GO:005506	INF	CYP7B1, CYCS, CYP2D6, CYP2C8, CYP2E1,
5	protein binding	GO:005515	INF	PRNP, EFEMP1, ADAM8, ADAMTS13, ADM, ADA
6	protein homodimerization activity	GO:042803	INF	HMOX1, DGAT2, OXA1L, SOD1, PON1, SLC6A4
7	cytokine activity	GO:005125	INF	, EDN1, TSLP, THPO, CXCL9, CSF3
8	hormone activity	GO:005179	INF	EDN1, EDN3, AGT, TTR, THPO, NPPA
9	growth factor activity	GO:008083	INF	IL1B, IL2, IL3, IL4, IL5, IL6
10	protein heterodimerization activity	GO:046982	INF	RXRA, , NR1H3, CYBB, TP53, ERBB2
11	heme binding	GO:020037	INF	CYP2B6, CYP2C19, CYP2E1, CYP2C8, CYP2D6, CYBB
12	protease binding	GO:002020	INF	F3, TP53, TNF, TNFRSF1A, ELANE, DPP4