MCID: LVR013
MIFTS: 70

Liver Disease malady

Liver diseases category

Summaries for Liver Disease

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32MalaCards
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MalaCards: Liver Disease, also known as liver disorder in pregnancy, is related to fatty liver disease and hepatitis. An important gene associated with Liver Disease is SERPINA1 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1), and among its related pathways is Selenium Pathway. The drugs alglucerase and imiglucerase and the compounds lipid and creatinine have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and bone, and related mouse phenotypes are homeostasis/metabolism and liver/biliary system.

Aliases & Classifications for Liver Disease

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Sources:
8Disease Ontology, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Aliases & Descriptions:

liver disease 8 30
liver disorder in pregnancy 8 60
liver disorder in pregnancy, unspecified as to episode of care 8
liver disorder in pregnancy, with delivery 8
liver disorder in pregnancy unspecified 8
liver disorder in pregnancy - delivered 8
liver disorder in pregnancy nos 8
unspecified disorder of liver 8
liver disorder antepartum 8
disease of the liver 8
liver disorder nos 8
disorder of liver 8
disease of liver 8
hepatic disorder 8
liver disorder 8
liver diseases 60


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Disease Ontology8 DOID:409
MeSH34 D008107
ICD9CM27 573.9
NCIt39 C3196

Related Diseases for Liver Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Liver Disease family:

Acute Liver Failure

Diseases related to Liver Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 501)
idRelated DiseaseScoreTop Affiliating Genes
1fatty liver disease31.9CYP2E1, SLC17A5, ADIPOQ
2hepatitis31.6GPT, SLC17A5
3hepatitis c31.2HFE, CYP2E1, GPT, F2, SLC17A5, KRT18
4obesity31.2HFE, CYP2E1, GPT, SLC17A5, GGT1, ADIPOQ
5hepatocellular carcinoma31.1HFE, CD14, CYP2E1, DLAT, GPT, F2
6alcoholic hepatitis31.0F2, CYP2E1
7hepatitis a31.0F2
8liver cirrhosis31.0ADIPOQ, SERPINA1, GGT1, KRT18, SLC17A5, F2
9hepatitis b31.0GGT1, SLC17A5, F2, GPT
10hypertension30.8F2, GGT1
11hemochromatosis30.7SERPINA1, HFE
12cystic fibrosis30.7ABCB11, KRT18, SERPINA1, SERPINA3
13portal hypertension30.7GPT, F2, SLC17A5, GGT1
14viral hepatitis30.6SLC17A5, F2, GPT, CD14, HFE, KRT18
15alcoholic liver cirrhosis30.6HFE, CYP2E1, GPT, F2, SLC17A5, GGT1
16cholestasis30.6SLC17A5, F2, ABCB11, GPT, HSD3B7, GGT1
17diabetes mellitus30.6HFE, CD14, CYP2E1, GPT, GGT1, SERPINA1
18atherosclerosis30.5CD14, GGT1, ADIPOQ
19alpha 1-antitrypsin deficiency30.5SERPINA3, SERPINA1
20acute liver failure30.5SLC17A5, F2, GPT
21galactosemia30.5GPT, F2, SLC17A5, GGT1, ADIPOQ
22autoimmune hepatitis30.5SEPSECS
23thrombocytopenia30.5SLC17A5, F2, GPT, HFE
24primary biliary cirrhosis30.5DLAT, PDHX
25alcohol dependence30.4GGT1
26alcohol abuse30.4HFE, CYP2E1, GPT, SLC17A5, GGT1
27type 2 diabetes mellitus30.4GPT, SLC17A5, GGT1, ADIPOQ
28peritonitis30.4F2, CD14
29cholangitis30.3DLAT, GPT, SLC17A5, GGT1, SEPSECS
30intrahepatic cholestasis30.3GGT1, SLC17A5, ABCB11
31neonatal hemochromatosis30.3SLC17A5, GGT1
32cryoglobulinemia30.3SLC17A5
33cholelithiasis30.3GPT, ABCB11, GGT1
34sclerosing cholangitis30.3SEPSECS
35brain disease30.2GPT, F2, SLC17A5, SERPINA3
36wilson disease30.2HFE, GPT, SLC17A5
37obstructive jaundice30.2GPT, SLC17A5, GGT1
38porphyria cutanea tarda30.2HFE
39porphyria30.2HFE
40hepatitis e30.2GPT
41hepatic encephalopathy30.2GPT, F2, SLC17A5
42pancreatitis30.1SERPINA1, GGT1, SLC17A5, CYP2E1
43cholangiocarcinoma30.1KRT18, GGT1
44colorectal cancer30.0CD14, CYP2E1, KRT18, SERPINA1
45leukemia30.0HFE, CD14, CYP2E1, ABCB11, SERPINA3
46siderosis30.0GPT, HFE
47cholestasis, progressive familial intrahepatic 130.0GGT1, ABCB11
48celiac disease30.0HFE
49polycystic ovary syndrome30.0ADIPOQ
50disseminated intravascular coagulation30.0F2, CD14

Graphical network of the top 20 diseases related to Liver Disease:



Diseases related to liver disease

Clinical Features for Liver Disease

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Drugs & Therapeutics for Liver Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Liver Disease

Drug clinical trials:

Search ClinicalTrials for Liver Disease

Search NIH Clinical Center for Liver Disease

Search CenterWatch for Liver Disease

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Liver Disease cell therapies at LifeMap Discovery.

Genetic Tests for Liver Disease

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Anatomical Context for Liver Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Liver Disease:

32
Liver, Kidney, Bone, Testes, Bone marrow, Spleen, Endothelial, Monocytes, Brain, Heart, Lung, T cells, Thyroid, Skin, B cells, Pituitary, Colon, Pancreas, Adipocyte, Fetal liver, Skeletal muscle, Prostate, Lymph node, Ovary, Breast, Eye, Placenta, Whole blood, Thymus, Tonsil, Appendix

Animal Models for Liver Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Liver Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.2HSD3B7, PRKCSH, HFE, CD14, CYP2E1, ABCB11
2MP:000537011.4HSD3B7, PRKCSH, HFE, CYP2E1, ABCB11, KRT18

Publications for Liver Disease

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Sources:
50PubMed
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Articles related to Liver Disease:

(show top 50)    (show all 3767)
idTitleAuthorsYear
1
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. (22902550)
2013
2
Serum uric acid levels and non-alcoholic fatty liver disease in Uyghur and Han ethnic groups in northwestern China. (24343630)
2013
3
Silymarin in non alcoholic fatty liver disease. (23556042)
2013
4
Oxymatrine ameliorates non-alcoholic fatty liver disease in rats through peroxisome proliferator-activated receptor-I+ activation. (23754536)
2013
5
Primary non-alcoholic fatty liver disease in hypertensive patients. (23837080)
2013
6
Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: a double-blind placebo-controlled study. (24065295)
2013
7
Assessment of splenic perfusion in patients with malignant hematologic diseases and spleen involvement, liver cirrhosis and controls using volume perfusion CT (VPCT): a pilot study. (22326669)
2012
8
Hepatitis E infection is an under recognized cause of acute decompensation in patients with chronic liver disease. (22592074)
2012
9
Boy with autosomal recessive polycystic kidney and autosomal dominant polycystic liver disease. (22415584)
2012
10
Loss of heterozygosity is present in SEC63 germline carriers with polycystic liver disease. (23209713)
2012
11
Safety of liver transplantation with Chagas disease-seropositive donors for seronegative recipients. (21618698)
2011
12
Hepatocellular MxA protein expression supports the differentiation of recurrent hepatitis C disease from acute cellular rejection after liver transplantation. (19712085)
2010
13
Liver disease without flipping: new functions of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1. (20512981)
2010
14
Extended liver resection for polycystic liver disease can challenge liver transplantation. (21037428)
2010
15
Levels of soluble CD40 ligand and P-Selectin in nonalcoholic fatty liver disease. (19440836)
2010
16
Recurrence of autoimmune disease, primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis after liver transplantation. (19876939)
2009
17
Polycystic liver disease treated with therapeutic excision. (19752867)
2009
18
High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection. (19669362)
2009
19
Linezolid an oral treatment option for staphylococcal liver abscess in chronic granulomatous disease. (19859022)
2009
20
Glutathione in liver diseases and hepatotoxicity. (18786561)
2009
21
Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease. (18473416)
2008
22
Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease. (18162065)
2008
23
Does retinol-binding protein 4 cause or reflect fatty liver disease? (18570262)
2008
24
TGF-beta1 and C-erb-B2 neu oncoprotein in Egyptian HCV related chronic liver disease and hepatocellular carcinoma patients. (20306668)
2008
25
Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease. (18591439)
2008
26
Nonalcoholic fatty liver disease as a risk factor of cardiovascular disease: relation of non-alcoholic fatty liver disease to carotid atherosclerosis]. (18367860)
2008
27
Reduced mobilisation of hematopoietic stem cells after hepatic resection for malignant liver disease. (18752047)
2008
28
Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics. (17430244)
2007
29
The serum level of certain aminoacids in chronic liver diseases associated with impaired oral glucose tolerance. (17236290)
2006
30
Association between vitamin D receptor, CCR5, TNF-alpha and TNF-beta gene polymorphisms and HBV infection and severity of liver disease. (16545485)
2006
31
Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease. (16394799)
2006
32
Leptin and fatty liver disease]. (15329225)
2004
33
Immunohistochemical detection of 1,N6-ethenodeoxyadenosine in nuclei of human liver affected by diseases predisposing to hepato-carcinogenesis. (14742317)
2004
34
Plasma P-selectin levels are elevated in patients with chronic liver disease. (12945872)
2003
35
Bone histomorphometric changes after liver transplantation for chronic cholestatic liver disease. (14672354)
2003
36
A new variant neuropathic type of Gaucher's disease characterized by hydrocephalus, corneal opacities, deformed toes, and fibrous thickening of spleen and liver capsules. (11148530)
2001
37
Independent patterns of cytochrome P450 gene expression in liver and blood in patients with suspected liver disease. (11599658)
2001
38
Splenomegaly, hypersplenism and coagulation abnormalities in liver disease. (11139352)
2000
39
Review: molecular approaches to inherited liver disease. Focus on Wilson disease. (9407345)
1997
40
Treatment of veno-occlusive disease of the liver with bolus tissue plasminogen activator and continuous infusion antithrombin III concentrate. (8704704)
1996
41
Creutzfeldt-Jakob disease after liver transplantation. (7654078)
1995
42
Colchicine in chronic liver disease of alcoholic etiology. Double-blind, randomized study of its effects on blood levels of plasma proteins and clinical course in patients]. (8574231)
1995
43
Liver lesion on computed tomography and ultrasonography in adult Niemann Pick disease related to sea blue histiocyte syndrome--a case report. (8325590)
1993
44
Pathogenesis of sodium and water retention in liver disease. (1296235)
1992
45
Metabolic alkalosis as driving force for urea synthesis in liver disease: pathogenetic model and therapeutic implications. (1600351)
1992
46
Alpha-fetoprotein alterations in alcoholics with liver disease. V.A. Cooperative Study Groups. (1725107)
1991
47
Clinicopathological analysis of alcoholic liver disease complicating chronic type C hepatitis. (1943504)
1991
48
Changes of dipeptidylpeptidase IV as a membrane marker of lymphocytes in acute and chronic liver diseases--biochemical and cytochemical investigations. (1681896)
1991
49
Hyperprolinemia and lactatemia in alcoholic liver disease: relationships to abstinence and histological findings. (2312066)
1990
50
Diminished micellar phase lipid in patients with chronic nonalcoholic liver disease and steatorrhea. (5423890)
1970

Genetic Variations for Liver Disease

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Expression for genes affiliated with Liver Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Liver Disease

Search GEO for disease gene expression data for Liver Disease.

Pathways for genes affiliated with Liver Disease

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Sources:
37NCBI BioSystems Database
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Pathways related to Liver Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0SERPINA3, GGT1, F2

Compounds for genes affiliated with Liver Disease

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Liver Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1lipid4412.8CYP2E1, HFE, GPT, ABCB11, CD14, ADIPOQ
2creatinine4412.6F2, CD14, CYP2E1, SERPINA3, SERPINA1, ADIPOQ
3cholesterol44 28 11 2415.5ABCB11, HFE, SLC17A5, SERPINA1, SERPINA3, ADIPOQ
4alanine4412.4KRT18, GGT1, HFE, SERPINA3, GPT, ADIPOQ
5ethanol44 49 11 2415.3GGT1, CYP2E1, SERPINA1, KRT18, SLC17A5, GPT
6fibrinogen4412.3SLC17A5, KRT18, SERPINA1, SERPINA3, ADIPOQ, F2
7lactate4412.3ADIPOQ, GGT1, KRT18, SLC17A5, F2, GPT
8aspartate4412.3ADIPOQ, GPT, F2, HFE, SLC17A5, KRT18
9nash4412.1KRT18, ADIPOQ, GGT1, SLC17A5, GPT, CYP2E1
10glucose4412.1KRT18, SERPINA1, SLC17A5, SERPINA3, CD14, ABCB11
11ascorbic acid44 2413.1GGT1, ADIPOQ, SERPINA1, KRT18, SLC17A5, CYP2E1
12iron44 2413.1KRT18, SLC17A5, GPT, HFE, GGT1, SERPINA1
13ursodeoxycholic acid44 11 2414.0F2, ABCB11, SLC17A5, GGT1, CYP2E1, GPT
14acetaminophen44 2 49 11 2415.9CYP2E1, GGT1, KRT18, SLC17A5, F2, GPT
15methotrexate44 49 1113.9ADIPOQ, F2, SLC17A5, GGT1, GPT, SERPINA3
16silymarin4411.8CYP2E1, F2, GGT1, GPT, SLC17A5
17rifampicin44 28 5913.7GPT, CYP2E1, ABCB11, SLC17A5, GGT1
18phenobarbital44 28 1113.7GGT1, GPT, SLC17A5, ABCB11, CYP2E1
19cyclosporin a44 28 5913.7SLC17A5, ABCB11, SEPSECS, CD14, F2, GPT
20verapamil44 49 28 11 2415.7CYP2E1, GGT1, ABCB11, SLC17A5, GPT
21urea44 11 2413.7SERPINA3, GGT1, KRT18, SLC17A5, GPT
22thyroxine44 2412.6SERPINA3, GPT, SLC17A5, GGT1, ADIPOQ
23tacrolimus44 49 1113.6SLC17A5, ABCB11, GPT, GGT1, ADIPOQ
24vitamin a44 11 2413.6CYP2E1, ADIPOQ, SERPINA3, SERPINA1
25aminopyrine4411.6F2, SLC17A5, GGT1, GPT
26sevoflurane44 1112.6SLC17A5, GPT, GGT1, CYP2E1
27antipyrine44 1112.6GGT1, SLC17A5, F2, CYP2E1
28pyruvate4411.6SLC17A5, GPT, DLAT, HFE, PDHX
29isoflurane44 1112.5GPT, SLC17A5, GGT1, CYP2E1
30rosuvastatin44 49 28 1114.5ADIPOQ, SLC17A5, GPT, ABCB11
31heparin44 28 11 2414.5CD14, ADIPOQ, SERPINA3, SERPINA1
32dexamethasone44 49 28 1114.5CYP2E1, KRT18, GGT1, ADIPOQ, CD14
33disulfiram44 59 1113.5GPT, CYP2E1, GGT1, SLC17A5
34bezafibrate44 28 1113.5GPT, SLC17A5, GGT1, ADIPOQ
35alpha lipoic acid4411.5SERPINA1, DLAT, GGT1, PDHX
36metformin44 49 1113.4GGT1, ADIPOQ, SLC17A5, GPT
37vitamin b124411.4SLC17A5, GPT, SERPINA3, GGT1
38betacarotene4411.4SLC17A5, SERPINA3, CYP2E1, GGT1
39lamivudine44 1112.4SLC17A5, ADIPOQ, F2
40hepaplastin4411.4F2, GPT, SLC17A5
41vinylchloride4411.3GGT1, SLC17A5, CYP2E1
42pioglitazone44 49 28 1114.3ADIPOQ, SLC17A5, GPT, GGT1
43glycocholate4411.3GPT, SLC17A5, ABCB11
44serine4411.3SERPINA3, ADIPOQ, SEPSECS, PDHX
45vitamin-e4411.2GGT1, SLC17A5, GPT, KRT18
46clozapine44 28 49 1114.1ADIPOQ, CYP2E1, GPT, GGT1
47uric acid44 2412.0HFE
48n acetylcysteine4411.0GPT, F2, SLC17A5, KRT18, GGT1
49nevirapine44 49 1113.0GGT1, SLC17A5, GPT
50isoniazid49 44 1113.0SLC17A5, CYP2E1, GPT

GO Terms for genes affiliated with Liver Disease

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16Gene Ontology
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Biological processes related to Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.4HSD3B7, PDHX, CYP2E1, DLAT, GPT, ABCB11
2acute-phase responseGO:00695311.0SERPINA3, SERPINA1, F2
3regulation of acetyl-CoA biosynthetic process from pyruvateGO:01051010.8DLAT, PDHX
4nitrogen compound metabolic processGO:00680710.7GPT, PRKCSH

Products for genes affiliated with Liver Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Liver Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet