MCID: LVR013
MIFTS: 62

Liver Disease malady

Summaries for Liver Disease

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33MalaCards
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MalaCards: Liver Disease, also known as liver disorder in pregnancy, is related to fatty liver disease and hepatitis c. An important gene associated with Liver Disease is SERPINA1 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1), and among its related pathways is Selenium Pathway. The drugs medium chain triglycerides and alglucerase and the compounds lipid and creatinine have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and liver/biliary system.

Aliases & Classifications for Liver Disease

Sources:
8Disease Ontology, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt
See all sources

Aliases & Descriptions:

liver disease 8 31
liver disorder in pregnancy 8 61
liver disorder in pregnancy, unspecified as to episode of care 8
liver disorder in pregnancy, with delivery 8
liver disorder in pregnancy unspecified 8
liver disorder in pregnancy - delivered 8
liver disorder in pregnancy nos 8
unspecified disorder of liver 8
liver disorder antepartum 8
disease of the liver 8
liver disorder nos 8
disorder of liver 8
disease of liver 8
hepatic disorder 8
liver disorder 8
liver diseases 61


External Ids:

Disease Ontology8 DOID:409
MeSH35 D008107
ICD9CM27 573.9
NCIt40 C3196

Related Diseases for Liver Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Liver Disease family:

acute liver failure

Diseases related to Liver Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 471)
idRelated DiseaseScoreTop Affiliating Genes
1fatty liver disease32.0CYP2E1, ADIPOQ, SLC17A5
2hepatitis c31.4GGT1, KRT18, SERPINA1, SLC17A5, F2, CYP2E1
3hepatitis a31.3F2
4insulin resistance31.2GPT, HFE, SLC17A5, CYP2E1, GGT1, ADIPOQ
5hepatitis e31.0GPT
6alcoholic hepatitis30.8CYP2E1, F2
7hemochromatosis30.8SERPINA1, HFE
8cystic fibrosis30.8SERPINA3, SERPINA1, KRT18, ABCB11
9hepatitis b30.8F2, SLC17A5, GPT, GGT1
10portal hypertension30.7GPT, GGT1, SLC17A5, F2
11alcoholic liver cirrhosis30.7CYP2E1, SLC17A5, F2, HFE, GGT1, GPT
12viral hepatitis30.6HFE, CD14, GPT, F2, SLC17A5, KRT18
13atherosclerosis30.6CD14, GGT1, ADIPOQ
14acute liver failure30.6SLC17A5, F2, GPT
15thrombocytopenia30.5SLC17A5, GPT, F2, HFE
16primary biliary cirrhosis30.5PDHX, DLAT
17autoimmune hepatitis30.5SEPSECS
18alcohol abuse30.5HFE, GPT, GGT1, SLC17A5, CYP2E1
19intrahepatic cholestasis30.4GGT1, SLC17A5, ABCB11
20neonatal hemochromatosis30.4SLC17A5, GGT1
21cryoglobulinemia30.4SLC17A5
22cholelithiasis30.3GGT1, ABCB11, GPT
23wilson disease30.3HFE, SLC17A5, GPT
24sclerosing cholangitis30.3SEPSECS
25alcohol dependence30.3GGT1
26brain disease30.3SERPINA3, SLC17A5, F2, GPT
27obstructive jaundice30.3SLC17A5, GPT, GGT1
28porphyria cutanea tarda30.3HFE
29thalassemia30.2HFE
30primary sclerosing cholangitis30.2GGT1, DLAT, GPT
31alpha 1-antitrypsin deficiency30.2SERPINA3, SERPINA1
32colorectal cancer30.1CYP2E1, KRT18, SERPINA1, CD14
33thromboembolism30.1SERPINA3, F2
34siderosis30.1HFE, GPT
35cholestasis, progressive familial intrahepatic 130.1ABCB11, GGT1
36celiac disease30.1HFE
37polycystic ovary syndrome30.1ADIPOQ
38hypercholesterolemia30.0GPT, CD14, ADIPOQ, GGT1, SLC17A5
39acute leukemia30.0CD14, HFE
40coronary heart disease29.9GGT1, ADIPOQ, HFE
41adenoma29.9GGT1, KRT18, HFE
42glucose intolerance29.9ADIPOQ, GPT
43pyridoxine deficiency29.9SLC17A5, GPT
44adenocarcinoma29.7SERPINA1, CYP2E1, ABCB11, KRT18, GGT1, SERPINA3
45primary hyperoxaluria29.7ADIPOQ, SERPINA1, CYP2E1, CD14, HFE
46type 2 diabetes mellitus29.7ADIPOQ, GGT1, SLC17A5, GPT
47hypertriglyceridemia29.7ADIPOQ, GGT1, GPT
48biliary atresia29.7GGT1, GPT
49tuberculosis29.7CYP2E1, SERPINA1
50vasculitis29.7SERPINA1, CD14, F2

Graphical network of the top 20 diseases related to Liver Disease:



Diseases related to liver disease

Clinical Features for Liver Disease

Drugs & Therapeutics for Liver Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Liver Disease

Drug clinical trials:

Search ClinicalTrials for Liver Disease

Search NIH Clinical Center for Liver Disease

Search CenterWatch for Liver Disease

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Liver Disease cell therapies at LifeMap Discovery.

Genetic Tests for Liver Disease

Anatomical Context for Liver Disease

Animal Models for Liver Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Liver Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.2HSD3B7, PRKCSH, HFE, CD14, CYP2E1, ABCB11
2MP:000537011.4HSD3B7, PRKCSH, HFE, CYP2E1, ABCB11, KRT18

Publications for Liver Disease

Sources:
51PubMed
See all sources

Articles related to Liver Disease:

(show top 50)    (show all 3772)
idTitleAuthorsYear
1
Obstructive sleep apnea syndrome affects liver histology and inflammatory cell activation in pediatric nonalcoholic Fatty liver disease, regardless of obesity/insulin resistance. (24256086)
2014
2
Test 6: hepatocellular carcinoma: illustrated guide to systematic radiologic diagnosis and staging according to guidelines of the american association for the study of liver diseases. (24428299)
2014
3
Ectopic fat, insulin resistance and non-alcoholic fatty liver disease. (23668723)
2013
4
Interactive effects of smoking and glutathione S-transferase polymorphisms on the development of non-alcoholic fatty liver disease. (23643483)
2013
5
The presence of hepatitis B core antibody is associated with more advanced liver disease in alcoholic patients with cirrhosis. (24041840)
2013
6
Relationship of non-alcoholic fatty liver disease with cholecystectomy in the US population. (23545713)
2013
7
The liver diseases of lipodystrophy: the long-term effect of leptin treatment. (23439261)
2013
8
Pediatric nonalcoholic fatty liver disease. (23917437)
2013
9
Characteristics of alcoholic liver disease and predictive factors for mortality of patients with alcoholic cirrhosis. (24322744)
2013
10
Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease. (23990360)
2013
11
Acute graft versus host disease after orthotopic liver transplantation. (22889203)
2012
12
PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. (21147840)
2011
13
Pivotal role of ADAMTS13 function in liver diseases. (20054668)
2010
14
Clinicopathological correlations in a series of adult patients with non-alcoholic fatty liver disease. (20398192)
2010
15
Association between angiotensin II type 1 receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease. (19302184)
2009
16
Children's toxicology from bench to bed--Liver Injury (3): Oxidative stress and anti-oxidant systems in liver of patients with Wilson disease. (19571474)
2009
17
Low circulating levels of dehydroepiandrosterone in histologically advanced nonalcoholic fatty liver disease. (18220286)
2008
18
Serum proteomics and biomarkers in hepatocellular carcinoma and chronic liver disease. (18223221)
2008
19
Effects of Yiqi Sanju Formula on non-alcoholic fatty liver disease: a randomized controlled trial]. (18664346)
2008
20
Brain atrophy in alcoholics: relationship with alcohol intake; liver disease; nutritional status, and inflammation. (17855333)
2007
21
The evolving role of leptin and adiponectin in chronic liver diseases. (16952281)
2006
22
New insights into the coagulopathy of liver disease and liver transplantation. (17203512)
2006
23
Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. (17096854)
2006
24
Liver dysfunction in steady state sickle cell disease. (16432491)
2005
25
Non-alcoholic fatty liver disease (NAFLD) in children. (15970496)
2005
26
Mechanisms of disease: adipocytokines and visceral adipose tissue--emerging role in nonalcoholic fatty liver disease. (16265231)
2005
27
Endoscopic stent insertion into the gallbladder for symptomatic gallbladder disease in patients with end-stage liver disease. (15672053)
2005
28
Nodular regenerative hyperplasia of the liver and Castleman's disease: potential role of interleukin-6. (15745091)
2005
29
Hypoadiponectinemia and insulin resistance are associated with nonalcoholic fatty liver disease. (15953863)
2005
30
Recent advances in alcoholic liver disease III. Role of the innate immune response in alcoholic hepatitis. (15246965)
2004
31
Hepatopulmonary syndrome and portopulmonary hypertension in the model for end-stage liver disease (MELD) era. (15382220)
2004
32
Elevated insulin, proinsulin and insulin-like growth factor-binding protein-1 in liver disease. (14624764)
2003
33
A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease. (14517792)
2003
34
Relationship between serum leptin and liver fibrosis in patients with alcoholic liver diseases]. (14636456)
2003
35
Alcoholic liver disease--established treatment and new therapeutic approaches]. (12695940)
2003
36
Histologic features of the liver in type Ia glycogen storage disease: comparative study between different age groups and consecutive biopsies. (12007023)
2002
37
Thrombocytopenia in liver disease. (11110614)
2000
38
'Hepatoma-specific' alphafetoprotein may permit preclinical diagnosis of malignant change in patients with chronic liver disease. (9010032)
1997
39
Incidence of liver disease in patients with cystic fibrosis and meconium ileus. (7815210)
1995
40
Molecular biological aspects of alcohol-induced liver disease. (7771656)
1995
41
Characterization of bile ducts in primary biliary cirrhosis and other liver diseases by immunohistochemical demonstration of Lewis(a) or b antigen. (7826978)
1994
42
The molecular basis of alpha 1-antichymotrypsin deficiency in a heterozygote with liver and lung disease. (8228125)
1993
43
Thrombin activation and increased fibrinolysis in patients with chronic liver disease. (1909901)
1991
44
Serum type-2 macro-creatine kinase isoenzyme is not a useful marker of severe liver diseases or neoplasia. (2289311)
1990
45
Effects of ursodeoxycholic acid therapy for liver disease associated with cystic fibrosis. (2391610)
1990
46
Effect of silimarin (Legalon) therapy on the antioxidant defense mechanism and lipid peroxidation in alcoholic liver disease (double blind protocol)]. (2345633)
1990
47
Acute liver disease and encephalopathy mimicking Reye syndrome. A report of three cases. (1185387)
1975
48
Hepatic coma secondary to metastatic liver disease. (5551164)
1971
49
Blood-ammonium levels in liver disease and hepatic coma. (14368880)
1955
50
Evaluation of clinical methods in gastro-intestinal disease. IV. Autopsy findings of liver disease (fatty infiltration, hepatic cirrhosis) observed in peptic ulcer cases. (14885142)
1951

Genetic Variations for Liver Disease

Expression for genes affiliated with Liver Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Liver Disease

Search GEO for disease gene expression data for Liver Disease.

Pathways for genes affiliated with Liver Disease

Sources:
38NCBI BioSystems Database
See all sources

Pathways related to Liver Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0SERPINA3, GGT1, F2

Compounds for genes affiliated with Liver Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Liver Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1lipid4512.8CYP2E1, HFE, GPT, ABCB11, CD14, ADIPOQ
2creatinine4512.6F2, CD14, CYP2E1, SERPINA3, SERPINA1, ADIPOQ
3cholesterol45 29 11 2415.5ABCB11, HFE, SLC17A5, SERPINA1, SERPINA3, ADIPOQ
4alanine4512.4KRT18, GGT1, HFE, SERPINA3, GPT, ADIPOQ
5ethanol45 50 11 2415.3GGT1, CYP2E1, SERPINA1, KRT18, SLC17A5, GPT
6fibrinogen4512.3SLC17A5, KRT18, SERPINA1, SERPINA3, ADIPOQ, F2
7lactate4512.3ADIPOQ, GGT1, KRT18, SLC17A5, F2, GPT
8aspartate4512.3ADIPOQ, GPT, F2, HFE, SLC17A5, KRT18
9nash4512.1KRT18, ADIPOQ, GGT1, SLC17A5, GPT, CYP2E1
10glucose4512.1KRT18, SERPINA1, SLC17A5, SERPINA3, CD14, ABCB11
11ascorbic acid45 2413.1GGT1, ADIPOQ, SERPINA1, KRT18, SLC17A5, CYP2E1
12iron45 2413.1KRT18, SLC17A5, GPT, HFE, GGT1, SERPINA1
13ursodeoxycholic acid45 11 2414.0F2, ABCB11, SLC17A5, GGT1, CYP2E1, GPT
14acetaminophen45 2 50 11 2415.9CYP2E1, GGT1, KRT18, SLC17A5, F2, GPT
15methotrexate45 50 1113.9ADIPOQ, F2, SLC17A5, GGT1, GPT, SERPINA3
16silymarin4511.8CYP2E1, F2, GGT1, GPT, SLC17A5
17rifampicin45 29 6013.7GPT, CYP2E1, ABCB11, SLC17A5, GGT1
18phenobarbital45 29 1113.7GGT1, GPT, SLC17A5, ABCB11, CYP2E1
19cyclosporin a45 29 6013.7SLC17A5, ABCB11, SEPSECS, CD14, F2, GPT
20verapamil45 50 29 11 2415.7CYP2E1, GGT1, ABCB11, SLC17A5, GPT
21urea45 11 2413.7SERPINA3, GGT1, KRT18, SLC17A5, GPT
22thyroxine45 2412.6SERPINA3, GPT, SLC17A5, GGT1, ADIPOQ
23tacrolimus45 50 1113.6SLC17A5, ABCB11, GPT, GGT1, ADIPOQ
24vitamin a45 11 2413.6CYP2E1, ADIPOQ, SERPINA3, SERPINA1
25aminopyrine4511.6F2, SLC17A5, GGT1, GPT
26sevoflurane45 1112.6SLC17A5, GPT, GGT1, CYP2E1
27antipyrine45 1112.6GGT1, SLC17A5, F2, CYP2E1
28pyruvate4511.6SLC17A5, GPT, DLAT, HFE, PDHX
29isoflurane45 1112.5GPT, SLC17A5, GGT1, CYP2E1
30rosuvastatin45 50 29 1114.5ADIPOQ, SLC17A5, GPT, ABCB11
31heparin45 29 11 2414.5CD14, ADIPOQ, SERPINA3, SERPINA1
32dexamethasone45 50 29 1114.5CYP2E1, KRT18, GGT1, ADIPOQ, CD14
33disulfiram45 60 1113.5GPT, CYP2E1, GGT1, SLC17A5
34bezafibrate45 29 1113.5GPT, SLC17A5, GGT1, ADIPOQ
35alpha lipoic acid4511.5SERPINA1, DLAT, GGT1, PDHX
36metformin45 50 1113.4GGT1, ADIPOQ, SLC17A5, GPT
37vitamin b124511.4SLC17A5, GPT, SERPINA3, GGT1
38betacarotene4511.4SLC17A5, SERPINA3, CYP2E1, GGT1
39lamivudine45 1112.4SLC17A5, ADIPOQ, F2
40hepaplastin4511.4F2, GPT, SLC17A5
41vinylchloride4511.3GGT1, SLC17A5, CYP2E1
42pioglitazone45 50 29 1114.3ADIPOQ, SLC17A5, GPT, GGT1
43glycocholate4511.3GPT, SLC17A5, ABCB11
44serine4511.3SERPINA3, ADIPOQ, SEPSECS, PDHX
45vitamin-e4511.2GGT1, SLC17A5, GPT, KRT18
46clozapine45 29 50 1114.1ADIPOQ, CYP2E1, GPT, GGT1
47uric acid45 2412.0HFE
48n acetylcysteine4511.0GPT, F2, SLC17A5, KRT18, GGT1
49nevirapine45 50 1113.0GGT1, SLC17A5, GPT
50isoniazid50 45 1113.0SLC17A5, CYP2E1, GPT

GO Terms for genes affiliated with Liver Disease

Sources:
16Gene Ontology
See all sources

Biological processes related to Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.4PDHX, CYP2E1, DLAT, GPT, ABCB11, GGT1
2acute-phase responseGO:00695311.0SERPINA3, SERPINA1, F2
3regulation of acetyl-CoA biosynthetic process from pyruvateGO:01051010.8PDHX, DLAT
4nitrogen compound metabolic processGO:00680710.7GPT, PRKCSH

Products for genes affiliated with Liver Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Liver Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet