MCID: LVR013
MIFTS: 69

Liver Disease malady

Gastrointestinal diseases, Liver diseases, Rare diseases categories
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Summaries for Liver Disease

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MalaCards based summary: Liver Disease, also known as disorder of liver, is related to fatty liver disease and hepatitis. An important gene associated with Liver Disease is PRKCSH (protein kinase C substrate 80K-H), and among its related pathways are Eicosanoid Synthesis and Selenium Pathway. The drugs medium chain triglycerides and alglucerase and the compounds glycocholate and hepaplastin have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Aliases & Classifications for Liver Disease

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Liver Disease, Aliases & Descriptions:

Name: Liver Disease 30 8
Disorder of Liver 8 62
 
Hepatic Disorder 8 62
Liver Diseases 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Liver diseases


External Ids:

Disease Ontology8 DOID:409
NCIt39 C3196
ICD9CM27 573.9
MeSH34 D008107

Related Diseases for Liver Disease

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Diseases in the Liver Disease family:

Acute Liver Failure

Diseases related to Liver Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 532)
idRelated DiseaseScoreTop Affiliating Genes
1fatty liver disease32.6CYP2E1, SLC17A5
2hepatitis31.7F2, CYP2E1, GPT, SERPINA1, HFE, GGT1
3hepatitis b31.4F2, GPT, GGT1, SLC17A5
4primary biliary cirrhosis31.3PDHX, DLAT
5insulin resistance31.2CYP2E1, GPT, RETN, HFE, RBP4, GGT1
6cystic fibrosis31.2RBP4, SERPINA3, SERPINA1, ABCB11
7alcoholic hepatitis31.2F2, CYP2E1
8hepatitis c31.1F2, CYP2E1, GPT, SERPINA1, HFE, RBP4
9obesity31.1CYP2E1, PNPLA3, GPT, RETN, HFE, RBP4
10hypertension31.1F2, RETN, GGT1
11neonatal hemochromatosis31.0GGT1, SLC17A5
12portal hypertension31.0F2, GPT, RETN, GGT1, SLC17A5
13intrahepatic cholestasis31.0ABCB11, GGT1, SLC17A5
14galactosemia31.0F2, GPT, GGT1, SLC17A5
15wilson disease30.9GPT, HFE, SLC17A5
16thrombocytopenia30.9SLC17A5, HFE, GPT, F2
17hepatitis a30.9F2
18acute liver failure30.9SLC17A5, GPT, F2
19cholelithiasis30.9ABCB11, GPT, GGT1
20cholangitis30.9SLC17A5, GGT1, DLAT, GPT
21autoimmune hepatitis30.9SLC17A5, GGT1, DLAT, GPT, F2
22obstructive jaundice30.8GPT, GGT1, SLC17A5
23primary sclerosing cholangitis30.8GPT, DLAT, GGT1
24emphysema due to aat deficiency30.8SERPINA1, SERPINA3
25hepatitis e30.8GPT
26cholestasis, progressive familial intrahepatic 130.8ABCB11, GGT1
27viral hepatitis30.7F2, GPT, SERPINA1, HFE, GGT1, SLC17A5
28alcohol abuse30.7CYP2E1, GPT, HFE, GGT1, SLC17A5
29hepatic encephalopathy30.7SLC17A5, GPT, F2
30siderosis30.7HFE, GPT
31pancreatitis30.7CYP2E1, SERPINA1, GGT1, SLC17A5
32biliary atresia30.6GGT1, GPT
33cholestasis30.6HSD3B7, GPT, ABCB11, F2, SERPINA1, RBP4
34diabetes mellitus30.6CYP2E1, GPT, SERPINA1, RETN, HFE, RBP4
35type 2 diabetes mellitus30.6GPT, RETN, RBP4, GGT1, SLC17A5
36pyridoxine deficiency30.6GPT, SLC17A5
37splenomegaly30.6SLC17A5, GPT
38panniculitis30.5SERPINA1
39opisthorchiasis30.4GGT1
40glucose intolerance30.3GPT, RETN, RBP4
41alcoholic liver cirrhosis30.2F2, CYP2E1, GPT, HFE, GGT1, SLC17A5
42liver cancer30.2F2, CYP2E1, GPT, SERPINA1, SERPINB3, HFE
43leukopenia30.2F2, GPT, SLC17A5
44liver cirrhosis30.1SLC17A5, GGT1, RBP4, HFE, RETN, SERPINA3
45primary hyperoxaluria29.9RBP4, HFE, RETN, SERPINA1, CYP2E1
46adenocarcinoma29.9ABCB11, CYP2E1, SERPINA1, SERPINB3, SERPINA3, GGT1
47substance abuse29.9CYP2E1, GGT1
48polycystic liver disease10.9
49hepatocellular carcinoma10.7
50hepatitis c virus10.7

Graphical network of the top 20 diseases related to Liver Disease:



Diseases related to liver disease

Symptoms for Liver Disease

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Drugs & Therapeutics for Liver Disease

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Drug clinical trials:

Search ClinicalTrials for Liver Disease

Search NIH Clinical Center for Liver Disease

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Liver Disease cell therapies at LifeMap Discovery.

Genetic Tests for Liver Disease

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Anatomical Context for Liver Disease

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MalaCards organs/tissues related to Liver Disease:

32
Liver, Bone, Testes, Kidney, Monocytes, Endothelial, T cells, Neutrophil, Bone marrow, Heart, Brain, Adipocyte, Lung, Thyroid, Prostate, Pituitary, Skeletal muscle, Skin, Ovary, B cells, Fetal liver, Spleen, Colon, Breast, Placenta, Whole blood, Pancreas

Animal Models for Liver Disease or affiliated genes

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MGI Mouse Phenotypes related to Liver Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.5CYP2E1, HSD3B7, PRKCSH, RETN, HFE, ABCB11
2MP:00053768.2SLC17A5, F2, ABCB11, CYP2E1, PNPLA3, HSD3B7

Publications for Liver Disease

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Articles related to Liver Disease:

(show top 50)    (show all 3172)
idTitleAuthorsYear
1
Nonalcoholic Fatty Liver Disease and Hyperuricemia: A Close Relation with Hepatic Insulin Resistance after Nicotinic Acid Treatment? (25350520)
2014
2
Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor I' activation. (23605066)
2013
3
Liver transplantation for alcoholic liver disease: a retrospective analysis of recidivism, survival and risk factors predisposing to alcohol relapse. (24261021)
2013
4
Hepatitis and liver disease knowledge and preventive practices among health workers in Mexico: a cross-sectional study. (24097058)
2013
5
Pediatric non-alcoholic fatty liver disease: an increasing public health issue. (24068459)
2013
6
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. (22902550)
2013
7
Simple noninvasive systems predict long-term outcomes of patients with nonalcoholic fatty liver disease. (23860502)
2013
8
Oral probiotic microcapsule formulation ameliorates non-alcoholic fatty liver disease in Bio F1B Golden Syrian hamsters. (23554890)
2013
9
Prevalence of restless legs syndrome in Japanese patients with chronic liver disease. (22672613)
2012
10
The Seroconversion Rate of Hepatitis A Virus Vaccination among Patients with Hepatitis B Virus-Related Chronic Liver Disease in Korea. (21814604)
2011
11
Mammary duct ectasia in a man with liver disease, end stage renal failure, and adjacent arteriovenous fistula. (22470751)
2010
12
Usefulness of non-invasive markers for predicting significant fibrosis in patients with chronic liver disease. (20052350)
2010
13
Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study. (20825652)
2010
14
Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. (19523535)
2009
15
Prevalence of subclinical vitamin K deficiency in cholestatic liver disease. (19502999)
2009
16
Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease. (18713296)
2009
17
Serum adipokine levels in chronic liver diseases: association of resistin levels with fibrosis severity. (18609175)
2008
18
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. (18242210)
2008
19
Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? (17482764)
2007
20
The prevalence of peripheral iron overload and the presence of HFE gene (H63D) mutation among the Korean patients with nonalcoholic fatty liver disease]. (17585191)
2007
21
Serum C-reactive protein and liver disease in patients with melioidosis. (17262186)
2007
22
Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3',5'-cyclic monophosphate. (17383431)
2007
23
Methylenetetrahydrofolate reductase C677T mutation and nonalcoholic fatty liver disease. (17356914)
2007
24
Non-invasive markers to predict the liver fibrosis in non-alcoholic fatty liver disease. (16911470)
2006
25
Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. (16618517)
2006
26
Expression of epithelial cellular adhesion molecule (Ep-CAM) in chronic (necro-)inflammatory liver diseases and hepatocellular carcinoma. (16364680)
2006
27
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. (16799979)
2006
28
Nonalcoholic fatty liver disease in India--is it different? (17542290)
2006
29
The serum level of certain aminoacids in chronic liver diseases associated with impaired oral glucose tolerance. (17236290)
2006
30
The role of PPAR alpha in the pathogenesis of fatty liver disease]. (16174475)
2005
31
Hepatorenal syndrome: a dreaded complication of end-stage liver disease. (15667508)
2005
32
Laparoscopic left lateral sectorectomy for polycystic liver disease. (12962449)
2003
33
Plasma P-selectin levels are elevated in patients with chronic liver disease. (12945872)
2003
34
C282Y and H63D mutations of HFE gene in patients with advanced alcoholic liver disease. (11469076)
2001
35
A useful ELISA system for human liver-type arginase, and its utility in diagnosis of liver diseases. (11676974)
2001
36
How is the liver primed or sensitized for alcoholic liver disease? (11391068)
2001
37
Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases. (11685552)
2001
38
Oxidative stress and antioxidant defense in alcoholic liver disease and chronic hepatitis C]. (10962902)
2000
39
Circulating intercellular adhesion molecule-1 in chronic liver disease and hepatocellular carcinoma. (10462824)
1999
40
Serum IgA antibodies to human gut luminal aspirates and human liver in alcoholic liver disease. (9802516)
1998
41
Hepatocellular carcinoma associated with alcoholic liver disease: a clinicopathological study and genetic polymorphism of aldehyde dehydrogenase 2. (8986242)
1996
42
Carbohydrate-deficient transferrin in alcohol and nonalcohol abusers with liver disease. (8749821)
1995
43
Liver transplantation for end-stage liver disease associated with alpha-1-antitrypsin deficiency in children: pretransplant natural history, timing and results of transplantation. (8201225)
1994
44
The prognosis of patients with alcoholic liver disease. An international randomized, placebo-controlled trial on the effect of malotilate on survival. (8051381)
1994
45
Detection of autoantibodies against M2, LKM-1, and SLA in liver diseases by standardized uniform ELISA-techniques. (7807283)
1994
46
Genotypes of ALDH2 related to liver and pulmonary diseases and other genetic factors related to alcoholic liver disease. (7695791)
1994
47
Lecithin-cholesterol acyltransferase and lipid transfer protein activities in liver disease. (8446043)
1993
48
The role of cytokines in the pathophysiology of chronic liver diseases. (8123873)
1993
49
Minor role of hepatitis B virus in the causation of chronic liver disease in Somalia indicated by a case-control study. (1712517)
1991
50
The gallbladder in polycystic liver disease. (7054544)
1982

Variations for Liver Disease

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Expression for genes affiliated with Liver Disease

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Expression patterns in normal tissues for genes affiliated with Liver Disease

Search GEO for disease gene expression data for Liver Disease.

Pathways for genes affiliated with Liver Disease

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Pathways related to Liver Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
aspirin triggered resolvin E biosynthesis37
10.0PNPLA3, GGT1
2
Show member pathways
thioredoxin pathway37
9.9GGT1, SERPINA3, F2
3
Show member pathways
9.1GPT, CYP2E1, PNPLA3, HSD3B7, PDHX, DLAT

Compounds for genes affiliated with Liver Disease

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Compounds related to Liver Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1glycocholate4410.3GPT, SLC17A5, ABCB11
2hepaplastin4410.3F2, SLC17A5, GPT
3vinylchloride4410.2GGT1, CYP2E1, SLC17A5
4sevoflurane50 44 1112.1GGT1, CYP2E1, SLC17A5, GPT
5aminopyrine4410.1SLC17A5, GGT1, GPT, F2
6alpha lipoic acid4410.1SERPINA1, PDHX, DLAT, GGT1
7isoflurane50 44 1112.1SLC17A5, GGT1, CYP2E1, GPT
8antipyrine44 1111.1CYP2E1, SLC17A5, GGT1, F2
9lutein4410.0SERPINA3, RBP4, GGT1
10disulfiram44 50 61 1113.0SLC17A5, CYP2E1, GPT, GGT1
11vitamin b124410.0GGT1, SERPINA3, SLC17A5, GPT
12phosphorus4410.0SLC17A5, RBP4, GGT1, GPT
13rifampicin44 28 6112.0CYP2E1, ABCB11, GPT, GGT1, SLC17A5
14pyruvate4410.0DLAT, SLC17A5, PDHX, HFE, GPT
15phenobarbital44 28 50 1113.0GGT1, GPT, SLC17A5, CYP2E1, ABCB11
16nevirapine44 50 1111.9GGT1, GPT, SLC17A5
17betacarotene449.9SLC17A5, CYP2E1, GGT1, RBP4, SERPINA3
18metformin44 50 1111.9GGT1, RETN, SLC17A5, GPT
19verapamil44 28 50 24 1113.9ABCB11, SLC17A5, CYP2E1, GPT, GGT1
20silymarin449.9SLC17A5, GPT, GGT1, F2, CYP2E1
21acetaminophen44 2 50 24 1113.9F2, CYP2E1, GPT, GGT1, SLC17A5
22vitamin-e449.9RBP4, SLC17A5, GGT1, GPT
23isoniazid44 50 1111.9GPT, CYP2E1, SLC17A5
24pioglitazone28 44 50 1112.9RETN, RBP4, SLC17A5, GGT1, GPT
25fibrinogen449.8GPT, SERPINA1, SERPINA3, RETN, SLC17A5, F2
26ursodeoxycholic acid44 24 1111.8SLC17A5, GGT1, ABCB11, F2, CYP2E1, GPT
27phospholipid449.8RBP4, PNPLA3, ABCB11, SLC17A5, F2, SERPINA1
28methotrexate50 44 1111.8SLC17A5, GGT1, SERPINA3, GPT, F2
29nash449.8CYP2E1, GPT, RETN, HFE, SLC17A5, GGT1
30ethanol44 50 24 1112.8GGT1, SLC17A5, GPT, SERPINA1, HFE, CYP2E1
31urea44 24 1111.8GPT, RETN, RBP4, SLC17A5, GGT1, SERPINA3
32thyroxine44 2410.7SLC17A5, GPT, SERPINA3, RETN, GGT1, RBP4
33ascorbic acid44 2410.7SLC17A5, GGT1, HFE, RBP4, SERPINA1, CYP2E1
34uric acid44 2410.7SLC17A5, GGT1, RBP4, HFE, RETN, GPT
35valproic acid44 50 24 1112.7GGT1, SLC17A5, CYP2E1, GPT
36tamoxifen44 50 28 1112.7SLC17A5, CYP2E1, GGT1, ABCB11, F2
37iron44 2410.6GGT1, SLC17A5, RBP4, SERPINA3, SERPINA1, GPT
38heparin44 28 24 1112.6SLC17A5, F2, PNPLA3, SERPINA1, GGT1, SERPINA3
39lactate449.5GGT1, SLC17A5, F2, GPT, RBP4, CYP2E1
40vitamin a44 24 1111.5GGT1, SERPINA1, CYP2E1, SERPINA3, SLC17A5, RETN
41aspartate449.5RBP4, HFE, GPT, F2, GGT1, SLC17A5
42estrogen449.4RBP4, HFE, F2, ABCB11, SERPINA1, SERPINA3
43creatinine449.2GPT, SERPINA1, SLC17A5, GGT1, RBP4, RETN
44cysteine449.2SERPINB3, GGT1, ABCB11, SERPINA1, CYP2E1, RBP4
45alanine449.2RETN, GPT, PNPLA3, F2, HFE, RBP4
46cholesterol44 28 24 1112.1SERPINA1, ABCB11, HFE, RBP4, GGT1, SLC17A5
47serine449.0SERPINA3, SERPINA1, GGT1, RBP4, PDHX, PNPLA3
48glucose449.0ABCB11, RETN, HFE, PDHX, RBP4, GGT1
49testosterone44 61 24 1112.0CYP2E1, RETN, HFE, RBP4, SLC17A5, GGT1
50lipid448.9PNPLA3, SLC17A5, SERPINA3, GGT1, RBP4, HFE

GO Terms for genes affiliated with Liver Disease

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Cellular components related to Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700629.2GGT1, RBP4, SERPINA3, SERPINB3, SERPINA1, GPT

Biological processes related to Liver Disease according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1maintenance of gastrointestinal epitheliumGO:03027710.2RBP4, SERPINA3
2acute-phase responseGO:00695310.2SERPINA3, SERPINA1, F2
3regulation of acetyl-CoA biosynthetic process from pyruvateGO:01051010.2PDHX, DLAT
4pyruvate metabolic processGO:00609010.2DLAT, PDHX
5regulation of proteolysisGO:03016210.2SERPINA1, SERPINB3, SERPINA3
6negative regulation of endopeptidase activityGO:01095110.1SERPINA3, SERPINB3, SERPINA1
7negative regulation of proteolysisGO:04586110.0SERPINB3, F2
8bile acid biosynthetic processGO:0066999.9HSD3B7, ABCB11
9small molecule metabolic processGO:0442819.3GGT1, ABCB11, CYP2E1, PNPLA3, GPT, HSD3B7

Molecular functions related to Liver Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00486710.0SERPINA3, SERPINB3, SERPINA1

Products for genes affiliated with Liver Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Liver Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet