MCID: LBL001
MIFTS: 50

Lobular Neoplasia malady

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Summaries for Lobular Neoplasia

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Wikipedia:65 Lobular neoplasia can refer to: more...

MalaCards based summary: Lobular Neoplasia, also known as lobular intraepithelial neoplasia, is related to breast fibroadenoma and ductal carcinoma in situ. An important gene associated with Lobular Neoplasia is LINS (lines homolog (Drosophila)), and among its related pathways are Ovarian Infertility Genes and Thyroid cancer. The compounds ly 117018 and 17alpha estradiol have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Aliases & Classifications for Lobular Neoplasia

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Lobular Neoplasia, Aliases & Descriptions:

Name: Lobular Neoplasia 8 10 62
Lobular Intraepithelial Neoplasia 8 62
 
Lobular Carcinoma in Situ 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:3010
NCIt39 C27939
ICD1025 D05.0

Related Diseases for Lobular Neoplasia

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Diseases related to Lobular Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1breast fibroadenoma31.1ESR1
2ductal carcinoma in situ31.0CDH1, ESR1
3breast cancer29.7ESR2, ESR1, PRLR, CDH1, CTNNB1, CTNND1
4hereditary diffuse gastric cancer10.5CDH1
5syringoma10.5MUC1
6cystadenocarcinoma10.4MUC1
7cerebral meningioma10.4PRLR
8progesterone resistance10.4ESR1
9microinvasive gastric cancer10.3CTNNA1, CDH1
10breast disease10.3
11goblet cell carcinoid10.2CTNNB1, CDH1
12mammary paget's disease10.2ESR1, MUC1
13endometrial stromal sarcoma10.2ESR1, ESR2
14inflammatory breast carcinoma10.2CDH1, ESR1
15breast cancer, invasive ductal10.2CDH1, ESR1
16malignant pleural mesothelioma10.2CTNNA1, MUC1
17neuroendocrine carcinoma10.2CDH1, MUC1
18abrikosov's tumor10.2ESR1, MUC1
19osteoporosis, postmenopausal10.2ESR1, ESR2
20breast ductal carcinoma10.2CDH1, ESR1, ESR2
21salivary gland adenoid cystic carcinoma10.2CTNNA1, CDH1, MUC1
22malignant mesothelioma10.2MUC1, CDH1, CTNNA1
23malignant mixed mullerian tumor10.1MUC1, CTNNB1
24cholangiocarcinoma10.1CTNNA1, CDH1, MUC1
25small cell carcinoma10.1
26chondrosarcoma10.1FGFR1, CTNNA1, MUC1
27papillary carcinoma10.1CDH1, MUC1, ESR1
28li-fraumeni syndrome10.1ESR2, ESR1, PRLR
29mucoepidermoid carcinoma10.1MUC1, CTNNA1
30gallbladder cancer10.1CTNNA1, CDH1
31synovial sarcoma10.1MUC1, CDH1, CTNNB1
32endometriosis10.1ESR2, ESR1, PRLR
33pancreatic cancer10.1ESR2, MUC1, CTNNB1
34meningioma10.0PRLR, MUC1, ESR1
35bladder carcinoma9.9CTNNA1, CDH1, HSP90AA1
36thyroid cancer, anaplastic9.9CDH1, CTNNB1
37colon adenocarcinoma9.9CTNND1, CTNNB1, CDH1, ESR2
38osteoporosis9.9ESR1, ESR2, HSP90AA1
39familial adenomatous polyposis9.8CDH1, CTNNB1, CTNND1, CTNNA1
40papillary thyroid carcinoma9.8ESR2, CDH1, CTNNB1, CTNNA1, FGFR1
41non-hodgkin lymphoma9.8HSP90AA1, CTNND1, FGFR1
42lung adenocarcinoma9.8ESR2, MUC1, CDH1, CTNNB1, CTNNA1
43infertility9.8PRLR, ESR1, ESR2, HSP90AA1
44glioblastoma9.7HSP90AA1, PRLR, CTNNA1, FGFR1
45ovarian cancer9.7CTNNB1, CDH1, MUC1, ESR1, ESR2
46colorectal cancer9.7ESR2, CDH1, CTNNB1, CTNND1, CTNNA1
47tubular adenocarcinoma9.7ESR1, MUC1, CDH1, CTNNB1, CTNNA1
48endometrial carcinoma9.7ESR2, ESR1, CDH1, CTNNB1, CTNND1
49burkitt's lymphoma9.6HSP90AA1, MUC1, PRLR, FGFR1
50lung cancer9.6HSP90AA1, ESR2, CDH1, CTNND1, CTNNA1

Graphical network of the top 20 diseases related to Lobular Neoplasia:



Diseases related to lobular neoplasia

Symptoms for Lobular Neoplasia

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Drugs & Therapeutics for Lobular Neoplasia

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Drug clinical trials:

Search ClinicalTrials for Lobular Neoplasia

Search NIH Clinical Center for Lobular Neoplasia

Genetic Tests for Lobular Neoplasia

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Anatomical Context for Lobular Neoplasia

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MalaCards organs/tissues related to Lobular Neoplasia:

32
Breast

Animal Models for Lobular Neoplasia or affiliated genes

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Publications for Lobular Neoplasia

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Articles related to Lobular Neoplasia:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast. (24948027)
2014
2
Evolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methods. (24633840)
2014
3
Lobular neoplasia: morphology and management. (25268198)
2014
4
Mucinous breast carcinoma with a lobular neoplasia component: a subset with aberrant expression of cell adhesion and polarity molecules and lack of neuroendocrine differentiation. (24888775)
2014
5
Lobular neoplasia. (24882347)
2014
6
Lobular neoplasia of the breast revisited with emphasis on the role of E-cadherin immunohistochemistry. (24441664)
2014
7
Classic lobular neoplasia on core biopsy: a clinical and radio-pathologic correlation study with follow-up excision biopsy. (23307062)
2013
8
Lobular neoplasia of the breast revisited with emphasis on the role of E-cadherin immunohistochemistry. (23759937)
2013
9
Long-term follow-up of lobular neoplasia (atypical lobular hyperplasia/lobular carcinoma in situ) diagnosed on core needle biopsy. (22847124)
2012
10
Cadherin-catenin complex dissociation in lobular neoplasia of the breast. (22080244)
2012
11
Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity. (21953071)
2012
12
Lobular lesions of the breast: imaging findings of lobular neoplasia and invasive lobular carcinoma. (22324264)
2012
13
Surgical outcome of biopsy-proven lobular neoplasia: is there any difference between lobular carcinoma in situ and atypical lobular hyperplasia? (22268170)
2012
14
Is excisional biopsy required after a breast core biopsy yields lobular neoplasia? (22997389)
2012
15
Pathologic findings of follow-up surgical excision for lobular neoplasia on breast core biopsy performed for calcification. (22706860)
2012
16
Lobular neoplasia: how to manage with partial understanding. (22106558)
2011
17
In situ lobular neoplasia of the breast with marked myoepithelial proliferation. (21707709)
2011
18
Lobular neoplasia of the breast. (20701604)
2010
19
Lobular neoplasia displaying central necrosis: a potential diagnostic pitfall. (20359832)
2010
20
Concurrent lobular neoplasia increases the risk of ipsilateral breast cancer recurrence in patients with ductal carcinoma in situ treated with breast-conserving therapy. (19170233)
2009
21
Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. (19294736)
2009
22
Is excisional biopsy indicated for patients with lobular neoplasia diagnosed on percutaneous core needle biopsy of the breast? (19969131)
2009
23
Sampling lobular neoplasia of the breast: underestimation despite technical success? (19466452)
2009
24
Lobular neoplasia in vacuum-assisted breast biopsy: extended protocols and underestimation. (18356422)
2008
25
Lobular neoplasia: is surgical excision warranted? (18306873)
2008
26
Interobserver variability and aberrant E-cadherin immunostaining of lobular neoplasia and infiltrating lobular carcinoma. (18587329)
2008
27
Lobular neoplasia: core needle breast biopsy underestimation of malignancy in relation to radiologic and pathologic features. (18619840)
2008
28
In situ and invasive lobular neoplasia of the breast. (18171417)
2008
29
Lobular neoplasia on core needle biopsy does not require excision. (18348299)
2008
30
Frequency and clinical significance of simultaneous association of lobular neoplasia and columnar cell alterations in breast tissue specimens. (18628095)
2008
31
Non-operative breast pathology: lobular neoplasia. (17182661)
2007
32
Wider excision following core biopsies of lobular neoplasia. (17983415)
2007
33
Flat epithelial atypia (DIN 1a, atypical columnar change): an underdiagnosed entity very frequently coexisting with lobular neoplasia. (17543075)
2007
34
Should the extent of lobular neoplasia on core biopsy influence the decision for excision? (17214794)
2007
35
High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma. (17325484)
2007
36
Lobular neoplasia diagnosed at core biopsy does not mandate surgical excision. (17662303)
2007
37
Management of lobular neoplasia diagnosed by core needle biopsy: study of 52 biopsies with follow-up surgical excision. (17629481)
2007
38
Genomic alterations in lobular neoplasia: a microarray comparative genomic hybridization signature for early neoplastic proliferationin the breast. (16897748)
2006
39
Lobular neoplasia in breast core needle biopsy specimens is associated with a low risk of ductal carcinoma in situ or invasive carcinoma on subsequent excision. (16891208)
2006
40
Lobular neoplasia at 11-gauge vacuum-assisted stereotactic biopsy: correlation with surgical excisional biopsy and mammographic follow-up. (16985141)
2006
41
Lobular Neoplasia within a Myoid Hamartoma of the Breast. (14717763)
2004
42
Lobular neoplasia on core-needle biopsy--clinical significance. (15481097)
2004
43
Atypical cystic lobules in patients with lobular neoplasia. (11584316)
2001
44
Uncommon morphologic patterns of lobular neoplasia. (10459051)
1999
45
Lobular neoplasia. Long term risk of breast cancer and relation to other factors. (8780540)
1996
46
Coexisting lobular neoplasia and carcinoma of the breast. (6297702)
1983
47
Lobular carcinoma in situ: (lobular neoplasia) of the breast (a symposium). (7443306)
1980
48
Morphometric and cytophotometric investigations of lobular neoplasia of the breast with ductal involvement. (468888)
1979
49
The nuclear DNA content of lobular neoplasia of the mammary gland. (578099)
1977
50
Neoplastic proliferation of the epithelium of the mammary lobules: adenosis, lobular neoplasia, and small cell carcinoma. (5020552)
1972

Variations for Lobular Neoplasia

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Expression for genes affiliated with Lobular Neoplasia

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Expression patterns in normal tissues for genes affiliated with Lobular Neoplasia

Search GEO for disease gene expression data for Lobular Neoplasia.

Pathways for genes affiliated with Lobular Neoplasia

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Pathways related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ESR2, PRLR
29.8CTNNB1, CDH1
3
Show member pathways
9.6CTNNA1, CTNNB1
49.6ESR2, ESR1
5
Show member pathways
9.6ESR2, ESR1
69.6ESR1, ESR2
79.6ESR1, ESR2
8
Show member pathways
9.5PRLR, ESR1
99.5FGFR1, CTNND1, CDH1
109.5CDH1, CTNNB1, FGFR1
11
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.4CTNNB1, CDH1, MUC1
129.4CTNNB1, CDH1, MUC1
139.4CTNNA1, CTNND1, CDH1
149.4CDH1, CTNNB1, CTNNA1
159.4CTNNA1, CTNNB1, CDH1
169.4CTNNA1, CTNNB1, CDH1
17
Show member pathways
RAC1 signaling pathway37
9.4CTNNA1, CTNNB1, CDH1
189.4CTNNA1, CTNNB1, CDH1
19
Show member pathways
Signal transduction PTEN pathway60
9.4CTNNA1, CTNNB1, CDH1
209.4CTNNA1, CTNNB1, CDH1
219.4CTNNA1, CTNNB1, CDH1
229.3HSP90AA1, ESR1
239.3ESR1, HSP90AA1
249.2CTNNB1, CTNND1, CTNNA1
259.2CTNNA1, CTNND1, CTNNB1
269.2CTNNA1, CTNND1, CTNNB1
27
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.2ESR2, ESR1, PRLR
28
Show member pathways
9.2FGFR1, PRLR, ESR1
299.1ESR1, CDH1, CTNNB1
309.1ESR1, CTNNB1, FGFR1
31
Show member pathways
9.0CDH1, CTNNB1, CTNND1, FGFR1
329.0CDH1, CTNNB1, CTNND1, CTNNA1
339.0CDH1, CTNNB1, CTNND1, CTNNA1
349.0CDH1, CTNNB1, CTNND1, CTNNA1
35
Show member pathways
9.0CDH1, CTNNB1, CTNND1, CTNNA1
369.0CDH1, CTNNB1, CTNND1, CTNNA1
379.0CDH1, CTNNB1, CTNND1, CTNNA1
38
Show member pathways
9.0CDH1, CTNNB1, CTNND1, CTNNA1
398.9CTNNB1, CTNND1, CTNNA1, FGFR1
40
Show member pathways
Signaling Pathways in Glioblastoma37
8.9HSP90AA1, CDH1, CTNNB1, FGFR1
41
Show member pathways
8.8HSP90AA1, CTNNB1, CTNNA1, FGFR1
428.8ESR2, ESR1, CTNNB1, FGFR1
43
Show member pathways
8.7HSP90AA1, ESR2, ESR1, FGFR1
44
Show member pathways
8.7CDH1, CTNNB1, CTNND1, CTNNA1, FGFR1
458.7FGFR1, CTNNA1, CTNND1, CTNNB1, CDH1
468.6MUC1, CDH1, CTNNB1, CTNND1, CTNNA1
47
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.6HSP90AA1, ESR2, ESR1, CTNNB1
488.6HSP90AA1, CDH1, CTNNB1, CTNNA1, FGFR1
49
Show member pathways
8.0HSP90AA1, ESR2, ESR1, CDH1, CTNNB1, FGFR1
50
Show member pathways
7.4ESR2, ESR1, MUC1, CDH1, CTNNB1, CTNND1

Compounds for genes affiliated with Lobular Neoplasia

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Compounds related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1ly 117018449.9ESR2, ESR1
217alpha estradiol449.9ESR2, ESR1
32,4,6-trichloro-4-biphenylol449.8ESR2, ESR1
4isobutylparaben449.8ESR1, ESR2
5isopropylparaben449.8ESR1, ESR2
64-octylphenol449.8ESR1, ESR2
7butylparaben449.8ESR2, ESR1
8methylparaben449.7ESR1, ESR2
9r,r-thc289.7ESR1, ESR2
10lasofoxifene449.7ESR2, ESR1
11zeranol449.6ESR1, ESR2
12crcs449.4CTNNB1, CDH1, MUC1
1312-o-tetradecanoylphorbol 13-acetate449.2CTNNA1, FGFR1, CDH1, PRLR, MUC1
14gefitinib44 50 1111.2CTNNB1, ESR2, CDH1, ESR1
15bicalutamide44 61 1111.2ESR1, ESR2, CTNNB1
16nocodazole44 1110.2HSP90AA1, CDH1, CTNNB1, CTNND1
17progestin449.1CDH1, PRLR, ESR2, ESR1, MUC1
18indole-3-carbinol449.0CTNNB1, ESR1, CDH1
194-hydroxytamoxifen449.0CTNNB1, ESR1, ESR2, HSP90AA1
20geldanamycin44 50 61 1112.0CDH1, HSP90AA1, ESR1, CTNNB1
21trastuzumab44 50 1111.0HSP90AA1, CTNNB1, MUC1, ESR1
22butyrate448.9MUC1, CDH1, PRLR, CTNNB1, HSP90AA1
23mg 13244 619.9ESR1, HSP90AA1, CDH1, CTNNB1
245-aza-2deoxycytidine448.9CTNNB1, ESR1, CDH1, ESR2, CTNNA1
25gnrh448.9ESR1, PRLR, CTNNB1, FGFR1, ESR2
26phosphotyrosine448.7FGFR1, PRLR, CDH1, CTNNA1, CTNNB1, CTNND1
275fluorouracil448.7CTNNB1, MUC1, HSP90AA1, ESR1, CDH1
28vitamin d448.7CDH1, CTNNB1, HSP90AA1, ESR2, ESR1
29mifepristone44 28 61 1111.7MUC1, ESR1, ESR2, HSP90AA1, CTNNB1
30doxorubicin44 50 1110.7HSP90AA1, ESR2, ESR1, CDH1, CTNNB1
31ly294002448.7FGFR1, CDH1, CTNNB1, ESR1, HSP90AA1
32dexamethasone44 50 28 1111.6CDH1, CTNNB1, HSP90AA1, MUC1, ESR2, PRLR
33glutamate448.6HSP90AA1, FGFR1, CTNNB1, CDH1, PRLR, ESR2
34cisplatin44 50 61 1111.6MUC1, CTNNB1, CDH1, ESR1, HSP90AA1
35threonine448.5FGFR1, HSP90AA1, MUC1, PRLR, CTNNB1, CTNND1
36dihydrotestosterone44 28 24 1111.4MUC1, ESR1, HSP90AA1, CTNNB1, ESR2, CDH1
37cysteine448.4FGFR1, CTNNB1, CDH1, PRLR, HSP90AA1, ESR2
38steroid448.3ESR1, ESR2, HSP90AA1, FGFR1, CTNNB1, PRLR
39paraffin448.2ESR2, ESR1, PRLR, CDH1, CTNNB1, CTNNA1
40genistein44 28 61 2 24 1113.1FGFR1, CDH1, PRLR, ESR1, ESR2, HSP90AA1
41retinoic acid44 249.1HSP90AA1, ESR1, MUC1, CDH1, CTNNB1, FGFR1
42tamoxifen44 50 28 1111.1CTNNB1, ESR2, CDH1, PRLR, MUC1, ESR1
43serine448.0FGFR1, HSP90AA1, ESR2, PRLR, CDH1, CTNNB1
44paclitaxel44 50 1110.0FGFR1, HSP90AA1, ESR1, CDH1, CTNNB1, CTNND1
45cycloheximide447.9CTNNB1, PRLR, ESR1, ESR2, HSP90AA1
46tyrosine447.9CTNNA1, MUC1, FGFR1, CTNND1, CTNNB1, CDH1
47progesterone44 28 61 24 1111.8ESR2, FGFR1, CTNNB1, CDH1, MUC1, HSP90AA1
48testosterone44 61 24 1110.8FGFR1, CDH1, CTNNB1, PRLR, ESR1, MUC1
49estrogen447.4HSP90AA1, ESR2, ESR1, MUC1, PRLR, CDH1
50vegf447.4FGFR1, HSP90AA1, ESR2, ESR1, MUC1, CDH1

GO Terms for genes affiliated with Lobular Neoplasia

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Cellular components related to Lobular Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:0098989.8CTNNB1, CDH1
2cell-cell adherens junctionGO:0059139.7CTNNB1, CDH1
3catenin complexGO:0163429.6CTNNA1, CTNNB1, CDH1
4zonula adherensGO:0059159.4CTNNB1, CTNND1, CTNNA1
5cell-cell junctionGO:0059119.3CTNNB1, CTNND1, CTNNA1
6lamellipodiumGO:0300279.2CTNNA1, CTNND1, CTNNB1
7extracellular regionGO:0055768.5HSP90AA1, ESR2, PRLR, CDH1, FGFR1
8plasma membraneGO:0058867.3HSP90AA1, ESR1, PRLR, CDH1, CTNNB1, CTNND1

Biological processes related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of protein localization to cell surfaceGO:200000810.0CTNNB1, CDH1
2lung-associated mesenchyme developmentGO:0604849.9FGFR1, CTNNB1
3positive regulation of phospholipase C activityGO:0108639.8FGFR1, ESR1
4ovarian follicle developmentGO:0015419.8CTNNA1, ESR2
5uterus developmentGO:0600659.8ESR1, ESR2
6positive regulation of muscle cell differentiationGO:0511499.8CTNNA1, CTNNB1
7vagina developmentGO:0600689.7ESR1, ESR2
8adherens junction organizationGO:0343329.7CTNNA1, CTNND1, CDH1
9cell-cell junction organizationGO:0452169.7CDH1, CTNND1, CTNNA1
10positive regulation of mesenchymal cell proliferationGO:0020539.7FGFR1, CTNNB1
11intracellular estrogen receptor signaling pathwayGO:0305209.7ESR2, ESR1
12cell junction assemblyGO:0343299.7CDH1, CTNND1, CTNNA1
13cellular response to indole-3-methanolGO:0716819.7CTNNA1, CTNNB1, CDH1
14neuron migrationGO:0017649.7ESR2, CTNNB1, FGFR1
15cell-cell adhesionGO:0163379.6CTNND1, CTNNB1, CDH1
16muscle cell differentiationGO:0426929.5CTNNA1, CTNNB1
17cell maturationGO:0484699.4FGFR1, CTNNB1
18positive regulation of nitric oxide biosynthetic processGO:0454299.4HSP90AA1, ESR1

Molecular functions related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1gamma-catenin bindingGO:0452959.8CDH1, CTNNA1
2estrogen response element bindingGO:0340569.8ESR1, ESR2
3estrogen receptor activityGO:0302849.7ESR1, ESR2
4protein phosphatase bindingGO:0199039.5CTNND1, CTNNB1, CDH1
5core promoter sequence-specific DNA bindingGO:0010469.5ESR1, ESR2
6cadherin bindingGO:0452969.5CTNNB1, CTNND1, CTNNA1
7nitric-oxide synthase regulator activityGO:0302359.4ESR1, HSP90AA1
8beta-catenin bindingGO:0080139.4ESR1, CDH1, CTNNA1
9steroid bindingGO:0054969.3ESR1, ESR2
10enzyme bindingGO:0198999.1CTNNB1, ESR1, ESR2
11protein bindingGO:0055156.3FGFR1, HSP90AA1, ESR2, ESR1, MUC1, PRLR

Products for genes affiliated with Lobular Neoplasia

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Sources for Lobular Neoplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet