MCID: LBL001
MIFTS: 46

Lobular Neoplasia malady

Categories: Cancer diseases

Aliases & Classifications for Lobular Neoplasia

Aliases & Descriptions for Lobular Neoplasia:

Name: Lobular Neoplasia 12 14 69
Lobular Carcinoma in Situ of Breast 69
Non-Infiltrating Lobular Carcinoma 69
Lobular Intraepithelial Neoplasia 12
Lobular Carcinoma in Situ 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3010
NCIt 47 C27939
ICD10 33 D05.0
UMLS 69 C0861352

Summaries for Lobular Neoplasia

MalaCards based summary : Lobular Neoplasia, also known as lobular carcinoma in situ of breast, is related to deafness, autosomal recessive 21 and granulocytopenia. An important gene associated with Lobular Neoplasia is CDH1 (Cadherin 1), and among its related pathways/superpathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. The drugs Hormones and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include breast, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and cellular

Wikipedia : 71 Lobular neoplasia can refer... more...

Related Diseases for Lobular Neoplasia

Diseases related to Lobular Neoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
id Related Disease Score Top Affiliating Genes
1 deafness, autosomal recessive 21 10.2 ESR1 ESR2
2 granulocytopenia 10.2 CDH1 CTNNB1
3 osteogenesis imperfecta 10.2 ESR1 ESR2
4 acute thyroiditis 10.2 ESR1 ESR2
5 neuroschistosomiasis 10.2 ESR1 ESR2
6 perinatal jaundice due to hepatocellular damage 10.2 ESR1 ESR2
7 glossopharyngeal motor neuropathy 10.2 CDH1 ERBB2
8 glioma 10.2 ERBB2 ESR1
9 deafness, autosomal recessive 74 10.2 ESR1 ESR2
10 adult neuronal ceroid lipofuscinosis 10.2 CDH1 ESR1
11 histiocytic and dendritic cell cancer 10.2 ERBB2 ESR1
12 hereditary breast ovarian cancer 10.2 ERBB2 ESR1
13 nervous system hibernoma 10.2 ERBB2 ESR1
14 basaloid squamous cell carcinoma 10.2 CDH1 ERBB2
15 carbuncle 10.2 ESR1 ESR2
16 central nervous system mature teratoma 10.2 ERBB2 ESR1
17 rectal neoplasm 10.2 ERBB2 ESR1
18 tanycytic ependymoma 10.2 CDH1 MUC1
19 postpartum depression 10.2 ERBB2 ESR1
20 malignant epithelial mesothelioma 10.1 CDH1 MUC1
21 bladder adenocarcinoma 10.1 ESR1 MUC1
22 anomalous left coronary artery from the pulmonary artery 10.1 ERBB2 ESR1
23 vulvar squamous papilloma 10.1 ESR1 MUC1
24 embryonal testis carcinoma 10.1 CDH1 MUC1
25 papilloma 10.1 CTNNB1 MUC1
26 peeling skin syndrome 10.1 CTNNB1 ESR1 ESR2
27 male reproductive organ benign neoplasm 10.1 ERBB2 ESR1
28 ulceroglandular tularemia 10.1 ESR1 ESR2 PRLR
29 combined t cell and b cell immunodeficiency 10.1 CDH1 ERBB2 ESR1
30 central nervous system primitive neuroectodermal neoplasm 10.1 ERBB2 ESR1
31 estrogen-receptor positive breast cancer 10.1 CDH1 ERBB2 ESR1
32 pyomyositis 10.1 CDH1 ERBB2 ESR1
33 pseudo-meigs syndrome 10.1 CDH1 CTNNB1
34 hepatocellular carcinoma 10.1 CDH1 CTNNA1
35 her2-receptor negative breast cancer 10.1 ERBB2 ESR1 ESR2
36 familial renal oncocytoma 10.1 CDH1 CTNNA1
37 ductal carcinoma in situ 10.1
38 bone marrow cancer 10.1 CTNNB1 MUC1
39 nemaline myopathy 8, autosomal recessive 10.1 CDH1 CTNNB1 ERBB2
40 pituitary stalk meningioma 10.1 ERBB2 ESR1 ESR2
41 angiolipomatosis, familial 10.1 ERBB2 MUC1
42 solitary plasmacytoma of chest wall 10.0 CDH1 CTNNB1 ERBB2
43 proctitis 10.0 CDH1 CTNNB1 ERBB2
44 reactive arthritis 10.0 CTNNB1 ERBB2 ESR2
45 differentiating neuroblastoma 10.0 CDH1 MUC1
46 placenta praevia 10.0 CDH1 CTNNB1 ERBB2
47 polyembryoma of the ovary 10.0 ERBB2 ESR1
48 acute eustachian salpingitis 10.0 CDH1 CTNNA1
49 gallbladder signet ring cell adenocarcinoma 10.0 CDH1 CTNNB1 MUC1
50 paroxysmal nocturnal hemoglobinuria 10.0 CDH1 CTNNB1 MUC1

Graphical network of the top 20 diseases related to Lobular Neoplasia:



Diseases related to Lobular Neoplasia

Symptoms & Phenotypes for Lobular Neoplasia

GenomeRNAi Phenotypes related to Lobular Neoplasia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 8.92 CTNNA1 CTNNB1 ERBB2 MUC1

MGI Mouse Phenotypes related to Lobular Neoplasia:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1 ESR2
2 endocrine/exocrine gland MP:0005379 10.03 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1 ESR2
3 cardiovascular system MP:0005385 9.99 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1 ESR2
4 growth/size/body region MP:0005378 9.95 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1 ESR2
5 embryo MP:0005380 9.93 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1 PRLR
6 integument MP:0010771 9.91 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1 ESR2
7 digestive/alimentary MP:0005381 9.88 CDH1 CTNNB1 ERBB2 ESR1 ESR2
8 limbs/digits/tail MP:0005371 9.8 CTNNA1 CTNNB1 ERBB2 ESR1 ESR2 PRLR
9 neoplasm MP:0002006 9.7 PRLR CDH1 CTNNA1 CTNNB1 ERBB2 ESR1
10 muscle MP:0005369 9.65 ESR1 ESR2 CTNNA1 CTNNB1 ERBB2
11 reproductive system MP:0005389 9.5 CDH1 CTNNB1 ERBB2 ESR1 ESR2 HSP90AA1
12 skeleton MP:0005390 9.1 CTNNA1 CTNNB1 ERBB2 ESR1 ESR2 PRLR

Drugs & Therapeutics for Lobular Neoplasia

Drugs for Lobular Neoplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 273)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
2
Estradiol Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-28-2 5757 53477783
3
Vinblastine Approved Phase 3,Phase 2,Phase 1 865-21-4 13342 241903
4
Paclitaxel Approved, Vet_approved Phase 2, Phase 3, Phase 1 33069-62-4 36314
5
Tamoxifen Approved Phase 3,Phase 2 10540-29-1 2733526
6
Vinorelbine Approved, Investigational Phase 3,Phase 2,Phase 1 71486-22-1 60780 44424639
7
Carboplatin Approved Phase 2, Phase 3, Phase 1 41575-94-4 10339178 498142 38904
8
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
9
Gemcitabine Approved Phase 3,Phase 2,Phase 1 95058-81-4 60750
10
Trastuzumab Approved, Investigational Phase 2, Phase 3, Phase 1 180288-69-1 9903
11
Fulvestrant Approved, Investigational Phase 3,Phase 2,Phase 1 129453-61-8 104741 17756771
12
Capecitabine Approved, Investigational Phase 3,Phase 2,Phase 1 154361-50-9 60953
13
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
14
Epirubicin Approved Phase 3,Phase 2,Phase 1 56420-45-2 41867
15
Doxorubicin Approved, Investigational Phase 2, Phase 3, Phase 1 23214-92-8 31703
16
Progesterone Approved, Vet_approved Phase 3,Phase 1,Phase 2,Early Phase 1 57-83-0 5994
17
Cisplatin Approved Phase 2, Phase 3, Phase 1 15663-27-1 84093 441203 2767
18
Toremifene Approved, Investigational Phase 3 89778-26-7 3005573
19
Letrozole Approved, Investigational Phase 3,Phase 2,Phase 1 112809-51-5 3902
20
Anastrozole Approved, Investigational Phase 3,Phase 2 120511-73-1 2187
21
Axitinib Approved, Investigational Phase 3 319460-85-0 6450551
22
Medroxyprogesterone acetate Approved, Investigational Phase 3 71-58-9
23
Metformin Approved Phase 3 657-24-9 14219 4091
24
Goserelin Approved Phase 2, Phase 3 65807-02-5 47725 5311128
25
Leuprolide Approved, Investigational Phase 2, Phase 3 53714-56-0 3911 657181
26
Exemestane Approved, Investigational Phase 3 107868-30-4 60198
27
Oxybutynin Approved, Investigational Phase 3 5633-20-5 4634
28
Pertuzumab Approved Phase 3,Phase 2 145040-37-5, 380610-27-5 2540
29
Fluorouracil Approved Phase 3,Phase 1,Phase 2 51-21-8 3385
30
Acetaminophen Approved Phase 3 103-90-2 1983
31
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
32
Imiquimod Approved, Investigational Phase 3 99011-02-6 57469
33
Petrolatum Approved Phase 3 8009-03-8
34
Docetaxel Approved May 1996, Investigational Phase 3,Phase 2 114977-28-5 148124 9877265
35
Lapatinib Approved March 2007, Investigational Phase 2, Phase 3 231277-92-2, 388082-78-8 208908 9941095
36
Doxil Approved June 1999 Phase 2, Phase 3, Phase 1 31703
37 Estradiol valerate Phase 3,Phase 2,Phase 1 979-32-8
38 Alkylating Agents Phase 3,Phase 2,Phase 1
39 Selective Estrogen Receptor Modulators Phase 3,Phase 2
40 Albumin-Bound Paclitaxel Phase 2, Phase 3, Phase 1
41 Topoisomerase Inhibitors Phase 2, Phase 3, Phase 1
42 Dermatologic Agents Phase 3,Phase 2,Phase 1
43 Hormone Antagonists Phase 3,Phase 2,Phase 1,Early Phase 1
44 Angiogenesis Inhibitors Phase 2, Phase 3,Phase 1
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1,Early Phase 1
46 Angiogenesis Modulating Agents Phase 2, Phase 3,Phase 1
47 Estradiol 17 beta-cypionate Phase 3,Phase 2,Phase 1
48 Estradiol 3-benzoate Phase 3,Phase 2,Phase 1
49 Estrogen Antagonists Phase 3,Phase 2,Phase 1
50 Anti-Bacterial Agents Phase 2, Phase 3, Phase 1

Interventional clinical trials:

(show top 50) (show all 271)
id Name Status NCT ID Phase
1 Electronic Xoft Intersociety Brachytherapy Trial: Electronic Brachytherapy (EBT) For Treatment of Early Stage Breast Cancer Completed NCT00742222 Phase 4
2 Phase IV Trial to Evaluate Breast Brachytherapy Using the Mammosite-Ml® Completed NCT01448447 Phase 4
3 Study of Autologous Fat Enhanced w/ Regenerative Cells Transplanted to Reconstruct Breast Deformities After Lumpectomy Completed NCT00616135 Phase 4
4 TARGIT-C(Consolidation) Prospective Phase IV Study of IORT in Patients With Small Breast Cancer Recruiting NCT02290782 Phase 4
5 Capecitabine (NX) Versus Docetaxel Plus Capecitabine (TX) as 1-line Chemotherapy on Metastatic Breast Cancer (MBC) Unknown status NCT01126138 Phase 3
6 S9630, Medroxyprogesterone in Treating Women With Breast Cancer Completed NCT00002920 Phase 3
7 Histology of Functional Density in Premenopausal Breast Completed NCT01588834 Phase 3
8 Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer in Postmenopausal Women Completed NCT00003906 Phase 3
9 Phase III Study of Atamestane Plus Toremifene Versus Letrozole in Advanced Breast Cancer Completed NCT00044291 Phase 3
10 Anastrozole or Tamoxifen in Treating Postmenopausal Women With Ductal Carcinoma in Situ Who Are Undergoing Lumpectomy and Radiation Therapy Completed NCT00053898 Phase 3
11 Evaluation of the Diagnostic Performance of MRI±Biopsy to Optimize Resection of Ductal Carcinoma In Situ (DCIS) Breast Cancer Completed NCT01112254 Phase 3
12 Conservative Surgery With or Without Axillary Lymphnode Removal in Treating Women With T1N0 Breast Cancer Completed NCT01508546 Phase 3
13 Study Of Gemcitabine Plus AG-013736 Versus Gemcitabine For Advanced Pancreatic Cancer. Completed NCT00471146 Phase 3
14 Intraoperative Gamma Camera for Breast Cancer Surgery Completed NCT00757302 Phase 3
15 Addition of Carboplatin to Neoadjuvant Therapy for Triple-negative and HER2-positive Early Breast Cancer Completed NCT01426880 Phase 2, Phase 3
16 Fulvestrant and/or Anastrozole in Treating Postmenopausal Patients With Stage II-III Breast Cancer Undergoing Surgery Recruiting NCT01953588 Phase 3
17 Metformin Hydrochloride in Patients With Atypical Hyperplasia or In Situ Breast Cancer to Placebo in Decreasing Atypical Cells in Patients With Atypical Hyperplasia or in Situ Breast Cancer Recruiting NCT01905046 Phase 3
18 Oxybutynin Chloride in Managing Hot Flashes Recruiting NCT02961790 Phase 3
19 Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Recruiting NCT01272037 Phase 3
20 Neoadjuvant Therapy in TRIPle Negative Breast Cancer With antiPDL1 Recruiting NCT02620280 Phase 3
21 Weekly Paclitaxel and Cisplatin to Treat Hormone Receptor Positive and Triple Negative Breast Cancer Patients Recruiting NCT02221999 Phase 2, Phase 3
22 Trial of Adjuvant Chemotherapy in Breast Cancer Patients With Pathological Partial Response to Neoadjuvant Chemotherapy Recruiting NCT02879513 Phase 3
23 A Phase III Trial Comparing Two Dose-dense, Dose-intensified Approaches (ETC and PM(Cb)) for Neoadjuvant Treatment of Patients With High-risk Early Breast Cancer (GeparOcto) Recruiting NCT02125344 Phase 3
24 A Study of Napabucasin Plus Nab-Paclitaxel With Gemcitabine in Adult Patients With Metastatic Pancreatic Adenocarcinoma Recruiting NCT02993731 Phase 3
25 Trial of Low Dose Tamoxifen in Women With Breast Intraepithelial Neoplasia Active, not recruiting NCT01357772 Phase 3
26 Exemestane in Preventing Cancer in Postmenopausal Women at Increased Risk of Developing Breast Cancer Active, not recruiting NCT00083174 Phase 3
27 Genetic Testing or Clinical Assessment in Determining the Need for Chemotherapy in Women With Breast Cancer That Involves No More Than 3 Lymph Nodes Active, not recruiting NCT00433589 Phase 3
28 Letrozole or Tamoxifen in Treating Postmenopausal Women With Breast Cancer Active, not recruiting NCT00004205 Phase 3
29 Spect Analysis of Cardiac Perfusion Changes After Whole Breast/Chest Wall Radiation Therapy With Active Breathing Coordinator Active, not recruiting NCT00321048 Phase 3
30 Nanoparticle-based Paclitaxel vs Solvent-based Paclitaxel as Part of Neoadjuvant Chemotherapy for Early Breast Cancer (GeparSepto) Active, not recruiting NCT01583426 Phase 3
31 Radiation Therapy With or Without Trastuzumab in Treating Women With Ductal Carcinoma In Situ Who Have Undergone Lumpectomy Active, not recruiting NCT00769379 Phase 3
32 Radiation Doses and Fractionation Schedules in Non-low Risk Ductal Carcinoma In Situ (DCIS) of the Breast Active, not recruiting NCT00470236 Phase 3
33 Topical 5% Imiquimod Cream for Vulvar Paget's Disease Enrolling by invitation NCT02385188 Phase 3
34 Treatment and Survival Continuation Study of Atamestane Plus Toremifene vs Letrozole in Advanced Breast Cancer Terminated NCT00267553 Phase 3
35 The CAT Study: Atamestane Plus Toremifene Versus Letrozole in Advanced Breast Cancer Terminated NCT00097344 Phase 3
36 "Phase II Study of PET Guided Neoadjuvant Chemotherapy (NAC) and Oncotype Guided Hormonal Therapy of Breast Cancer" Unknown status NCT01641406 Phase 2
37 Tamoxifen in Preventing Breast Cancer in Women at Increased Risk for Breast Cancer Unknown status NCT00096369 Phase 2
38 Effect of Omega 3 on Atrophic Vaginitis in Breast Cancer Survivors Unknown status NCT02150525 Phase 2
39 Chemotherapy Selection Based on Therapeutic Targets for Advanced Pancreatic Cancer Unknown status NCT01394120 Phase 2
40 Efficacy Study of Gemcitabine, Paclitaxel, and Irradiation in the Treatment of Pancreatic Cancer Unknown status NCT00226746 Phase 2
41 Study Of Intraductal Carboplatin In Women With Ductal Carcinoma In Situ (DCIS) Unknown status NCT00669747 Phase 2
42 Single-arm Study of Photodynamic Laser Therapy Using Foscan for Non-curatively-resectable Bile Duct Carcinoma Unknown status NCT01016002 Phase 2
43 Open Label Trial for Post-Menopausal Women With Newly Diagnosed Operable Breast Cancer Completed NCT00161291 Phase 2
44 Doxorubicin Hydrochloride Liposome as First-Line Therapy in Treating Older Women With Metastatic Breast Cancer Completed NCT00960336 Phase 2
45 Paclitaxel and Carboplatin in Treating Women Who Are Undergoing Surgery for Newly Diagnosed, Locally Advanced Breast Cancer Completed NCT00096343 Phase 2
46 Carboplatin and Nab-Paclitaxel With or Without Vorinostat in Treating Women With Newly Diagnosed Operable Breast Cancer Completed NCT00616967 Phase 2
47 Combination Chemotherapy With or Without Trastuzumab Followed By an Autologous Stem Cell Transplant and Radiation Therapy in Treating Patients With Stage III or Stage IV Breast Cancer Completed NCT00182793 Phase 2
48 Soy Protein Supplement In Treating Hot Flashes in Postmenopausal Women Receiving Tamoxifen for Breast Disease Completed NCT00031720 Phase 2
49 Three Different Programs of Paced Breathing in Treating Hot Flashes in Women Completed NCT00569166 Phase 2
50 Study of the Efficacy of Chloroquine in the Treatment of Ductal Carcinoma in Situ (The PINC Trial) Completed NCT01023477 Phase 1, Phase 2

Search NIH Clinical Center for Lobular Neoplasia

Genetic Tests for Lobular Neoplasia

Anatomical Context for Lobular Neoplasia

MalaCards organs/tissues related to Lobular Neoplasia:

39
Breast

Publications for Lobular Neoplasia

Articles related to Lobular Neoplasia:

(show top 50) (show all 87)
id Title Authors Year
1
Sonographic Appearance of Lesions Diagnosed as Lobular Neoplasia at Sonographically Guided Biopsies. ( 28075608 )
2017
2
Surgical Outcomes of Lobular Neoplasia Diagnosed in Core Biopsy: Prospective Study ofA 316 Cases. ( 27425222 )
2016
3
CD10-positive myoepithelial cells are usually prominent around in situ lobular neoplasia of the breast and much less prominent or absent in DCIS. ( 26862059 )
2016
4
When pathological and radiological correlation is achieved, excision of fibroadenoma with lobular neoplasia on core biopsy is not warranted. ( 27718416 )
2016
5
Lobular neoplasia detected in MRI-guided core biopsy carries a high risk for upgrade: a study of 63 cases from four different institutions. ( 26564004 )
2016
6
The radiological features, diagnosis and management of screen-detected lobular neoplasia of the breast: Findings from the Sloane Project. ( 27060553 )
2016
7
Lobular Neoplasia: Another Reset in Management? ( 26676981 )
2016
8
Lobular neoplasia diagnosed on breast Core biopsy: frequency of carcinoma on excision and implications for management. ( 27806840 )
2016
9
Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In-situ in Patients with Lobular Neoplasia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 020). ( 26542585 )
2015
10
Mucinous breast carcinoma with a lobular neoplasia component: a subset with aberrant expression of cell adhesion and polarity molecules and lack of neuroendocrine differentiation. ( 24888775 )
2014
11
Lobular neoplasia: morphology and management. ( 25268198 )
2014
12
Evolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methods. ( 24633840 )
2014
13
Lobular neoplasia of the breast revisited with emphasis on the role of E-cadherin immunohistochemistry. ( 24441664 )
2014
14
Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast. ( 24948027 )
2014
15
Lobular neoplasia. ( 24882347 )
2014
16
Classic lobular neoplasia on core biopsy: a clinical and radio-pathologic correlation study with follow-up excision biopsy. ( 23307062 )
2013
17
Lobular neoplasia: what does it mean and how should it be treated? ( 23617527 )
2013
18
Lobular neoplasia of the breast revisited with emphasis on the role of E-cadherin immunohistochemistry. ( 23759937 )
2013
19
Lobular lesions of the breast: imaging findings of lobular neoplasia and invasive lobular carcinoma. ( 22324264 )
2012
20
Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity. ( 21953071 )
2012
21
Is excisional biopsy required after a breast core biopsy yields lobular neoplasia? ( 22997389 )
2012
22
Pathologic findings of follow-up surgical excision for lobular neoplasia on breast core biopsy performed for calcification. ( 22706860 )
2012
23
Surgical outcome of biopsy-proven lobular neoplasia: is there any difference between lobular carcinoma in situ and atypical lobular hyperplasia? ( 22268170 )
2012
24
Long-term follow-up of lobular neoplasia (atypical lobular hyperplasia/lobular carcinoma in situ) diagnosed on core needle biopsy. ( 22847124 )
2012
25
Cadherin-catenin complex dissociation in lobular neoplasia of the breast. ( 22080244 )
2012
26
Low frequency of cancer occurrence in same breast quadrant diagnosed with lobular neoplasia at percutaneous needle biopsy. ( 22344406 )
2012
27
Breast-specific gamma imaging in the detection of atypical ductal hyperplasia and lobular neoplasia. ( 22578225 )
2012
28
Lobular neoplasia found on breast biopsy: marker of increased risk of malignancy or direct pre-cancerous lesion? ( 22038220 )
2011
29
Lobular neoplasia: how to manage with partial understanding. ( 22106558 )
2011
30
Amplification of the prolactin receptor gene in mammary lobular neoplasia. ( 20658264 )
2011
31
Lobular neoplasia: frequency and association with other breast lesions. ( 21827679 )
2011
32
In situ lobular neoplasia of the breast with marked myoepithelial proliferation. ( 21707709 )
2011
33
Lobular neoplasia: evolution of its significance and morphologic spectrum. ( 20484286 )
2010
34
Lobular neoplasia displaying central necrosis: a potential diagnostic pitfall. ( 20359832 )
2010
35
Management of in situ lobular neoplasia detected on needle core biopsy of breast. ( 20972243 )
2010
36
Lobular neoplasia of the breast. ( 20701604 )
2010
37
Lobular neoplasia: morphology, biological potential and management in core biopsies. ( 20436498 )
2010
38
Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. ( 19294736 )
2009
39
Lobular neoplasia of the breast: 68 years on. ( 19089737 )
2009
40
Concurrent lobular neoplasia increases the risk of ipsilateral breast cancer recurrence in patients with ductal carcinoma in situ treated with breast-conserving therapy. ( 19170233 )
2009
41
Is excisional biopsy indicated for patients with lobular neoplasia diagnosed on percutaneous core needle biopsy of the breast? ( 19969131 )
2009
42
Lobular neoplasia of the breast: an update. ( 19642738 )
2009
43
Sampling lobular neoplasia of the breast: underestimation despite technical success? ( 19466452 )
2009
44
In situ and invasive lobular neoplasia of the breast. ( 18171417 )
2008
45
Lobular neoplasia: is surgical excision warranted? ( 18306873 )
2008
46
Lobular neoplasia at percutaneous breast biopsy: variables associated with carcinoma at surgical excision. ( 18287433 )
2008
47
Interobserver variability and aberrant E-cadherin immunostaining of lobular neoplasia and infiltrating lobular carcinoma. ( 18587329 )
2008
48
Lobular neoplasia: core needle breast biopsy underestimation of malignancy in relation to radiologic and pathologic features. ( 18619840 )
2008
49
Frequency and clinical significance of simultaneous association of lobular neoplasia and columnar cell alterations in breast tissue specimens. ( 18628095 )
2008
50
Lobular neoplasia on core needle biopsy does not require excision. ( 18348299 )
2008

Variations for Lobular Neoplasia

Cosmic variations for Lobular Neoplasia:

9 (show top 50) (show all 117)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM638 WNK1 breast,NS,carcinoma,lobular carcinoma c.1255G>C p.E419Q 7
2 COSM637 WNK1 breast,NS,carcinoma,lobular carcinoma c.6569C>G p.S2190C 7
3 COSM17721 VHL breast,NS,carcinoma,lobular carcinoma c.241C>T p.P81S 7
4 COSM51319 USP28 breast,NS,carcinoma,lobular carcinoma c.2050G>A p.D684N 7
5 COSM6188 TRIM33 breast,NS,carcinoma,lobular carcinoma c.2968-1G>C p.? 7
6 COSM11196 TP53 breast,NS,carcinoma,lobular carcinoma c.734G>T p.G245V 7
7 COSM11552 TP53 breast,NS,carcinoma,lobular carcinoma c.775G>T p.D259Y 7
8 COSM43695 TP53 breast,NS,carcinoma,lobular carcinoma c.748C>T p.P250S 7
9 COSM43606 TP53 breast,NS,carcinoma,lobular carcinoma c.734G>A p.G245D 7
10 COSM10728 TP53 breast,NS,carcinoma,lobular carcinoma c.839G>A p.R280K 7
11 COSM10648 TP53 breast,NS,carcinoma,lobular carcinoma c.524G>A p.R175H 7
12 COSM10722 TP53 breast,NS,carcinoma,lobular carcinoma c.853G>A p.E285K 7
13 COSM10726 TP53 breast,NS,carcinoma,lobular carcinoma c.856G>A p.E286K 7
14 COSM10768 TP53 breast,NS,carcinoma,lobular carcinoma c.535C>T p.H179Y 7
15 COSM629 STK32B breast,NS,carcinoma,lobular carcinoma c.940G>T p.E314* 7
16 COSM6165 STK32B breast,NS,carcinoma,lobular carcinoma c.910-1G>C p.? 7
17 COSM649 SNRK breast,NS,carcinoma,lobular carcinoma c.2295C>G p.I765M 7
18 COSM647 SMG1 breast,NS,carcinoma,lobular carcinoma c.6500C>G p.S2167C 7
19 COSM6160 SMG1 breast,NS,carcinoma,lobular carcinoma c.5932C>T p.Q1978* 7
20 COSM84438 SMAD4 breast,NS,carcinoma,lobular carcinoma c.247C>T p.Q83* 7
21 COSM6162 SGK494 breast,NS,carcinoma,lobular carcinoma c.836G>A p.R279Q 7
22 COSM646 SGK2 breast,NS,carcinoma,lobular carcinoma c.381G>A p.Q127Q 7
23 COSM51308 RNASEH2A breast,NS,carcinoma,lobular carcinoma c.872G>A p.R291H 7
24 COSM1659143 RB1 breast,NS,carcinoma,lobular carcinoma c.2077G>T p.E693* 7
25 COSM763 PIK3CA breast,NS,carcinoma,lobular carcinoma c.1633G>A p.E545K 7
26 COSM775 PIK3CA breast,NS,carcinoma,lobular carcinoma c.3140A>G p.H1047R 7
27 COSM757 PIK3CA breast,NS,carcinoma,lobular carcinoma c.1258T>C p.C420R 7
28 COSM760 PIK3CA breast,NS,carcinoma,lobular carcinoma c.1624G>A p.E542K 7
29 COSM12592 PIK3CA breast,NS,carcinoma,lobular carcinoma c.3132T>A p.N1044K 7
30 COSM746 PIK3CA breast,NS,carcinoma,lobular carcinoma c.263G>A p.R88Q 7
31 COSM764 PIK3CA breast,NS,carcinoma,lobular carcinoma c.1634A>G p.E545G 7
32 COSM762 PIK3CA breast,NS,carcinoma,lobular carcinoma c.1625A>T p.E542V 7
33 COSM776 PIK3CA breast,NS,carcinoma,lobular carcinoma c.3140A>T p.H1047L 7
34 COSM648 NUAK2 breast,NS,carcinoma,lobular carcinoma c.1622G>A p.G541E 7
35 COSM612 NTRK3 breast,NS,carcinoma,lobular carcinoma c.2033G>A p.R678Q 7
36 COSM611 NPR1 breast,NS,carcinoma,lobular carcinoma c.809T>G p.F270C 7
37 COSM51304 MYH8 breast,NS,carcinoma,lobular carcinoma c.2640G>C p.M880I 7
38 COSM51313 MORC1 breast,NS,carcinoma,lobular carcinoma c.698C>T p.A233V 7
39 COSM640 MOK breast,NS,carcinoma,lobular carcinoma c.816G>C p.E272D 7
40 COSM1659156 MEN1 breast,NS,carcinoma,lobular carcinoma c.496C>T p.Q166* 7
41 COSM12780 MAP3K19 breast,NS,carcinoma,lobular carcinoma c.1500C>G p.I500M 7
42 COSM607 MAP3K12 breast,NS,carcinoma,lobular carcinoma c.1225G>A p.E409K 7
43 COSM1659155 MAP2K4 breast,NS,carcinoma,lobular carcinoma c.513+2T>C p.? 7
44 COSM605 LYN breast,NS,carcinoma,lobular carcinoma c.1153G>T p.D385Y 7
45 COSM518 KRAS breast,NS,carcinoma,lobular carcinoma c.34G>C p.G12R 7
46 COSM527 KRAS breast,NS,carcinoma,lobular carcinoma c.37G>T p.G13C 7
47 COSM1272082 KIT breast,NS,carcinoma,lobular carcinoma c.1262T>A p.L421H 7
48 COSM51331 KIF1C breast,NS,carcinoma,lobular carcinoma c.873G>A p.K291K 7
49 COSM51330 KIAA1468 breast,NS,carcinoma,lobular carcinoma c.2081G>A p.R694K 7
50 COSM51299 HAUS3 breast,NS,carcinoma,lobular carcinoma c.1657G>A p.V553M 7

Expression for Lobular Neoplasia

Search GEO for disease gene expression data for Lobular Neoplasia.

Pathways for Lobular Neoplasia

Pathways related to Lobular Neoplasia according to GeneCards Suite gene sharing:

(show all 43)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1 ESR2
2
Show member pathways
13.05 CDH1 CTNNB1 ERBB2 ESR1 ESR2 HSP90AA1
3
Show member pathways
12.61 CTNNB1 ESR1 ESR2 HSP90AA1
4
Show member pathways
12.59 CDH1 CTNNB1 ERBB2 ESR1 ESR2 HSP90AA1
5
Show member pathways
12.58 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1
6 12.4 CDH1 CTNNA1 CTNNB1 ERBB2 HSP90AA1
7
Show member pathways
12.31 ERBB2 ESR1 ESR2 PRLR
8
Show member pathways
12.25 CTNNB1 ESR1 HSP90AA1
9
Show member pathways
12.22 CDH1 CTNNB1 ERBB2 HSP90AA1 MUC1
10
Show member pathways
12.2 CDH1 CTNNA1 CTNNB1 ERBB2
11
Show member pathways
12.17 ERBB2 ESR1 ESR2
12 12.14 CTNNB1 ERBB2 ESR1
13
Show member pathways
12.1 CDH1 CTNNA1 CTNNB1
14
Show member pathways
12.05 CTNNA1 CTNNB1 HSP90AA1
15 11.97 CDH1 CTNNA1 CTNNB1
16 11.97 CDH1 CTNNB1 ESR1
17 11.92 CDH1 CTNNA1 CTNNB1
18
Show member pathways
11.79 ERBB2 ESR1 PRLR
19 11.62 CDH1 CTNNA1 CTNNB1
20 11.5 CDH1 CTNNA1 CTNNB1 MUC1
21 11.33 CDH1 CTNNA1 CTNNB1
22 11.31 ESR1 HSP90AA1
23 11.29 CTNNA1 CTNNB1
24 11.26 CDH1 CTNNA1 CTNNB1
25 11.23 CDH1 CTNNA1 CTNNB1
26 11.21 ESR1 HSP90AA1
27 11.2 CTNNA1 CTNNB1
28 11.18 CTNNA1 CTNNB1
29 11.18 ESR2 PRLR
30 11.16 CDH1 ERBB2
31 11.15 CDH1 CTNNA1 CTNNB1
32 11.14 CTNNB1 ERBB2
33 11.13 CDH1 CTNNA1 CTNNB1
34 11.12 CDH1 CTNNB1
35 11.1 ESR1 ESR2
36 11.06 ESR1 ESR2
37 11.04 ESR1 HSP90AA1
38 11 ESR1 ESR2
39 10.94 CDH1 CTNNA1 CTNNB1
40 10.9 CDH1 CTNNA1
41 10.78 CDH1 CTNNA1 CTNNB1 ERBB2
42 10.25 CDH1 CTNNA1 CTNNB1
43 10.14 ESR1 ESR2

GO Terms for Lobular Neoplasia

Cellular components related to Lobular Neoplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.92 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1 HSP90AA1
2 lamellipodium GO:0030027 9.54 CDH1 CTNNA1 CTNNB1
3 cell-cell adherens junction GO:0005913 9.33 CDH1 CTNNA1 CTNNB1
4 apical junction complex GO:0043296 9.26 CDH1 CTNNB1
5 catenin complex GO:0016342 9.13 CDH1 CTNNA1 CTNNB1
6 flotillin complex GO:0016600 8.8 CDH1 CTNNA1 CTNNB1

Biological processes related to Lobular Neoplasia according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.76 CDH1 CTNNB1 ESR1 ESR2
2 ERBB2 signaling pathway GO:0038128 9.51 ERBB2 HSP90AA1
3 positive regulation of telomerase activity GO:0051973 9.49 CTNNB1 HSP90AA1
4 regulation of angiogenesis GO:0045765 9.48 CTNNB1 ERBB2
5 positive regulation of muscle cell differentiation GO:0051149 9.43 CTNNA1 CTNNB1
6 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.43 CTNNB1 ESR1 ESR2
7 intracellular estrogen receptor signaling pathway GO:0030520 9.4 ESR1 ESR2
8 mammary gland alveolus development GO:0060749 9.37 ESR1 PRLR
9 entry of bacterium into host cell GO:0035635 9.32 CDH1 CTNNB1
10 regulation of epithelial cell differentiation GO:0030856 9.16 CTNNB1 PRLR
11 adherens junction organization GO:0034332 9.13 CDH1 CTNNA1 CTNNB1
12 cellular response to indole-3-methanol GO:0071681 8.8 CDH1 CTNNA1 CTNNB1

Molecular functions related to Lobular Neoplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 beta-catenin binding GO:0008013 9.5 CDH1 CTNNA1 ESR1
2 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.48 ESR1 ESR2
3 estrogen receptor binding GO:0030331 9.46 CTNNB1 ESR1
4 steroid binding GO:0005496 9.43 ESR1 ESR2
5 disordered domain specific binding GO:0097718 9.4 CTNNB1 HSP90AA1
6 gamma-catenin binding GO:0045295 9.37 CDH1 CTNNA1
7 nitric-oxide synthase regulator activity GO:0030235 9.26 ESR1 HSP90AA1
8 estrogen receptor activity GO:0030284 9.16 ESR1 ESR2
9 estrogen response element binding GO:0034056 8.96 ESR1 ESR2
10 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.62 ESR1 ESR2

Sources for Lobular Neoplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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