MCID: LBL001
MIFTS: 47

Lobular Neoplasia malady

Cancer diseases category

Summaries for Lobular Neoplasia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Lobular neoplasia can refer to: more...

MalaCards: Lobular Neoplasia, also known as lobular intraepithelial neoplasia, is related to ductal carcinoma in situ and breast fibroadenoma. An important gene associated with Lobular Neoplasia is LINS (lines homolog (Drosophila)), and among its related pathways are Ovarian Infertility Genes and Thyroid cancer. The compounds ly 117018 and 17alpha estradiol have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Aliases & Classifications for Lobular Neoplasia

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9Disease Ontology, 11DISEASES, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

lobular neoplasia 9 11 63
lobular intraepithelial neoplasia 9


External Ids:

Disease Ontology9 DOID:3010
NCIt41 C27939

Related Diseases for Lobular Neoplasia

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18GeneCards, 19GeneDecks
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Diseases related to Lobular Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1ductal carcinoma in situ30.6ESR1, CDH1
2breast fibroadenoma30.6ESR1
3breast cancer30.2ESR2, ESR1, PRLR, CDH1, CTNNB1, CTNND1
4gynecomastia10.1
5small cell carcinoma10.1
6hereditary diffuse gastric cancer10.1CDH1
7syringoma10.1MUC1
8cystadenocarcinoma10.1MUC1
9cerebral meningioma10.1PRLR
10progesterone resistance10.1ESR1
11microinvasive gastric cancer10.1CDH1, CTNNA1
12goblet cell carcinoid10.1CTNNB1, CDH1
13mammary paget's disease10.1MUC1, ESR1
14endometrial stromal sarcoma10.1ESR1, ESR2
15inflammatory breast carcinoma10.1ESR1, CDH1
16breast cancer, invasive ductal10.0CDH1, ESR1
17malignant pleural mesothelioma10.0CTNNA1, MUC1
18neuroendocrine carcinoma10.0CDH1, MUC1
19abrikosov's tumor10.0ESR1, MUC1
20osteoporosis, postmenopausal10.0ESR2, ESR1
21adenoid cystic carcinoma10.0CTNNA1, MUC1, CDH1
22malignant mesothelioma10.0CTNNA1, MUC1, CDH1
23malignant mixed mullerian tumor10.0CTNNB1, MUC1
24cholangiocarcinoma10.0MUC1, CDH1, CTNNA1
25chondrosarcoma10.0MUC1, FGFR1, CTNNA1
26papillary carcinoma10.0ESR1, MUC1, CDH1
27li-fraumeni syndrome10.0ESR2, ESR1, PRLR
28mucoepidermoid carcinoma10.0CTNNA1, MUC1
29gallbladder cancer10.0CTNNA1, CDH1
30synovial sarcoma10.0MUC1, CTNNB1, CDH1
31endometriosis10.0ESR1, ESR2, PRLR
32pancreatic cancer10.0CTNNB1, MUC1, ESR2
33meningioma10.0MUC1, PRLR, ESR1
34bladder carcinoma10.0HSP90AA1, CTNNA1, CDH1
35thyroid cancer, anaplastic10.0CDH1, CTNNB1
36colon adenocarcinoma10.0CTNNB1, CTNND1, CDH1, ESR2
37osteoporosis10.0HSP90AA1, ESR2, ESR1
38familial adenomatous polyposis10.0CTNNA1, CTNNB1, CTNND1, CDH1
39non-hodgkin lymphoma9.9CTNND1, FGFR1, HSP90AA1
40papillary thyroid carcinoma9.9CTNNA1, FGFR1, CTNNB1, CDH1, ESR2
41lung adenocarcinoma9.9CTNNA1, ESR2, MUC1, CDH1, CTNNB1
42infertility9.9ESR1, HSP90AA1, PRLR, ESR2
43glioblastoma multiforme9.9FGFR1, CTNNA1, HSP90AA1, PRLR
44ovarian cancer9.9CTNNB1, MUC1, ESR2, CDH1, ESR1
45colorectal cancer9.9CDH1, CTNNB1, CTNND1, CTNNA1, ESR2
46tubular adenocarcinoma9.9CTNNB1, CDH1, CTNNA1, ESR1, MUC1
47endometrial carcinoma9.9CTNND1, CDH1, CTNNB1, ESR2, ESR1
48burkitt's lymphoma9.9MUC1, FGFR1, PRLR, HSP90AA1
49lung cancer9.9CTNND1, CDH1, CTNNA1, ESR2, HSP90AA1
50kidney cancer9.9CTNND1, CDH1, MUC1, HSP90AA1, CTNNA1

Graphical network of the top 20 diseases related to Lobular Neoplasia:



Diseases related to lobular neoplasia

Symptoms for Lobular Neoplasia

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Drugs & Therapeutics for Lobular Neoplasia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Lobular Neoplasia

Drug clinical trials:

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Search NIH Clinical Center for Lobular Neoplasia

Search CenterWatch for Lobular Neoplasia

Genetic Tests for Lobular Neoplasia

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Anatomical Context for Lobular Neoplasia

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34MalaCards
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MalaCards organs/tissues related to Lobular Neoplasia:

34
Breast

Animal Models for Lobular Neoplasia or affiliated genes

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38MGI
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Publications for Lobular Neoplasia

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53PubMed
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Articles related to Lobular Neoplasia:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Classic lobular neoplasia on core biopsy: a clinical and radio-pathologic correlation study with follow-up excision biopsy. (23307062)
2013
2
Lobular neoplasia of the breast revisited with emphasis on the role of E-cadherin immunohistochemistry. (23759937)
2013
3
Long-term follow-up of lobular neoplasia (atypical lobular hyperplasia/lobular carcinoma in situ) diagnosed on core needle biopsy. (22847124)
2012
4
Cadherin-catenin complex dissociation in lobular neoplasia of the breast. (22080244)
2012
5
Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity. (21953071)
2012
6
Lobular lesions of the breast: imaging findings of lobular neoplasia and invasive lobular carcinoma. (22324264)
2012
7
Surgical outcome of biopsy-proven lobular neoplasia: is there any difference between lobular carcinoma in situ and atypical lobular hyperplasia? (22268170)
2012
8
Is excisional biopsy required after a breast core biopsy yields lobular neoplasia? (22997389)
2012
9
Pathologic findings of follow-up surgical excision for lobular neoplasia on breast core biopsy performed for calcification. (22706860)
2012
10
Breast-specific gamma imaging in the detection of atypical ductal hyperplasia and lobular neoplasia. (22578225)
2012
11
Lobular neoplasia: how to manage with partial understanding. (22106558)
2011
12
In situ lobular neoplasia of the breast with marked myoepithelial proliferation. (21707709)
2011
13
Lobular neoplasia: frequency and association with other breast lesions. (21827679)
2011
14
Amplification of the prolactin receptor gene in mammary lobular neoplasia. (20658264)
2011
15
Lobular neoplasia of the breast. (20701604)
2010
16
Lobular neoplasia displaying central necrosis: a potential diagnostic pitfall. (20359832)
2010
17
Concurrent lobular neoplasia increases the risk of ipsilateral breast cancer recurrence in patients with ductal carcinoma in situ treated with breast-conserving therapy. (19170233)
2009
18
Is excisional biopsy indicated for patients with lobular neoplasia diagnosed on percutaneous core needle biopsy of the breast? (19969131)
2009
19
Sampling lobular neoplasia of the breast: underestimation despite technical success? (19466452)
2009
20
Lobular neoplasia in vacuum-assisted breast biopsy: extended protocols and underestimation. (18356422)
2008
21
Lobular neoplasia: is surgical excision warranted? (18306873)
2008
22
Interobserver variability and aberrant E-cadherin immunostaining of lobular neoplasia and infiltrating lobular carcinoma. (18587329)
2008
23
Lobular neoplasia: core needle breast biopsy underestimation of malignancy in relation to radiologic and pathologic features. (18619840)
2008
24
In situ and invasive lobular neoplasia of the breast. (18171417)
2008
25
Lobular neoplasia on core needle biopsy does not require excision. (18348299)
2008
26
Frequency and clinical significance of simultaneous association of lobular neoplasia and columnar cell alterations in breast tissue specimens. (18628095)
2008
27
Non-operative breast pathology: lobular neoplasia. (17182661)
2007
28
Wider excision following core biopsies of lobular neoplasia. (17983415)
2007
29
Flat epithelial atypia (DIN 1a, atypical columnar change): an underdiagnosed entity very frequently coexisting with lobular neoplasia. (17543075)
2007
30
Should the extent of lobular neoplasia on core biopsy influence the decision for excision? (17214794)
2007
31
Lobular neoplasia diagnosed at core biopsy does not mandate surgical excision. (17662303)
2007
32
Management of lobular neoplasia diagnosed by core needle biopsy: study of 52 biopsies with follow-up surgical excision. (17629481)
2007
33
Genomic alterations in lobular neoplasia: a microarray comparative genomic hybridization signature for early neoplastic proliferationin the breast. (16897748)
2006
34
Lobular neoplasia in breast core needle biopsy specimens is associated with a low risk of ductal carcinoma in situ or invasive carcinoma on subsequent excision. (16891208)
2006
35
Lobular neoplasia at 11-gauge vacuum-assisted stereotactic biopsy: correlation with surgical excisional biopsy and mammographic follow-up. (16985141)
2006
36
Evolving concepts in the management of lobular neoplasia. (16687097)
2006
37
The evolution of lobular neoplasia. (16858149)
2006
38
Lobular Neoplasia within a Myoid Hamartoma of the Breast. (14717763)
2004
39
Lobular neoplasia on core-needle biopsy--clinical significance. (15481097)
2004
40
Lobular neoplasia on core-needle biopsy--clinical significance. (15241819)
2004
41
In-situ lobular neoplasia: time for an awakening. (12531570)
2003
42
Atypical cystic lobules in patients with lobular neoplasia. (11584316)
2001
43
Uncommon morphologic patterns of lobular neoplasia. (10459051)
1999
44
Lobular neoplasia. Long term risk of breast cancer and relation to other factors. (8780540)
1996
45
Gynecomastia with unusual intraductal "clear cell" changes mimicking pagetoid ductal spread of lobular neoplasia. (7567685)
1995
46
Coexisting lobular neoplasia and carcinoma of the breast. (6297702)
1983
47
Lobular carcinoma in situ: (lobular neoplasia) of the breast (a symposium). (7443306)
1980
48
Morphometric and cytophotometric investigations of lobular neoplasia of the breast with ductal involvement. (468888)
1979
49
The nuclear DNA content of lobular neoplasia of the mammary gland. (578099)
1977
50
Neoplastic proliferation of the epithelium of the mammary lobules: adenosis, lobular neoplasia, and small cell carcinoma. (5020552)
1972

Variations for Lobular Neoplasia

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Expression for genes affiliated with Lobular Neoplasia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lobular Neoplasia

Search GEO for disease gene expression data for Lobular Neoplasia.

Pathways for genes affiliated with Lobular Neoplasia

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 56Reactome, 54QIAGEN, 52PharmGKB, 61Thomson Reuters, 58SinoBiological, 5Cell Signaling Technology
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Pathways related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ESR2, PRLR
29.8CTNNB1, CDH1
3
Show member pathways
9.6CTNNA1, CTNNB1
49.6ESR2, ESR1
5
Show member pathways
9.6ESR2, ESR1
69.6ESR1, ESR2
79.6ESR1, ESR2
8
Show member pathways
9.5PRLR, ESR1
99.5FGFR1, CTNND1, CDH1
109.5CDH1, CTNNB1, FGFR1
11
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
9.4CTNNB1, CDH1, MUC1
129.4CTNNB1, CDH1, MUC1
139.4CTNNA1, CTNND1, CDH1
149.4CDH1, CTNNB1, CTNNA1
159.4CTNNA1, CTNNB1, CDH1
169.4CTNNA1, CTNNB1, CDH1
17
Show member pathways
RAC1 signaling pathway39
9.4CTNNA1, CTNNB1, CDH1
189.4CTNNA1, CTNNB1, CDH1
19
Show member pathways
Signal transduction PTEN pathway61
9.4CTNNA1, CTNNB1, CDH1
209.4CTNNA1, CTNNB1, CDH1
219.4CTNNA1, CTNNB1, CDH1
229.3HSP90AA1, ESR1
239.3ESR1, HSP90AA1
249.2CTNNB1, CTNND1, CTNNA1
259.2CTNNA1, CTNND1, CTNNB1
269.2CTNNA1, CTNND1, CTNNB1
27
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.2ESR2, ESR1, PRLR
28
Show member pathways
9.2FGFR1, PRLR, ESR1
299.1ESR1, CDH1, CTNNB1
309.1ESR1, CTNNB1, FGFR1
31
Show member pathways
9.0CDH1, CTNNB1, CTNND1, FGFR1
329.0CDH1, CTNNB1, CTNND1, CTNNA1
339.0CDH1, CTNNB1, CTNND1, CTNNA1
349.0CDH1, CTNNB1, CTNND1, CTNNA1
35
Show member pathways
9.0CDH1, CTNNB1, CTNND1, CTNNA1
369.0CDH1, CTNNB1, CTNND1, CTNNA1
379.0CDH1, CTNNB1, CTNND1, CTNNA1
38
Show member pathways
9.0CDH1, CTNNB1, CTNND1, CTNNA1
398.9CTNNB1, CTNND1, CTNNA1, FGFR1
40
Show member pathways
Signaling Pathways in Glioblastoma39
8.9HSP90AA1, CDH1, CTNNB1, FGFR1
41
Show member pathways
8.8HSP90AA1, CTNNB1, CTNNA1, FGFR1
428.8ESR2, ESR1, CTNNB1, FGFR1
43
Show member pathways
8.7HSP90AA1, ESR2, ESR1, FGFR1
44
Show member pathways
8.7CDH1, CTNNB1, CTNND1, CTNNA1, FGFR1
458.7FGFR1, CTNNA1, CTNND1, CTNNB1, CDH1
468.6MUC1, CDH1, CTNNB1, CTNND1, CTNNA1
47
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
8.6HSP90AA1, ESR2, ESR1, CTNNB1
488.6HSP90AA1, CDH1, CTNNB1, CTNNA1, FGFR1
49
Show member pathways
8.0HSP90AA1, ESR2, ESR1, CDH1, CTNNB1, FGFR1
50
Show member pathways
7.4ESR2, ESR1, MUC1, CDH1, CTNNB1, CTNND1

Compounds for genes affiliated with Lobular Neoplasia

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1ly 117018469.9ESR2, ESR1
217alpha estradiol469.9ESR2, ESR1
32,4,6-trichloro-4-biphenylol469.8ESR2, ESR1
4isobutylparaben469.8ESR1, ESR2
5isopropylparaben469.8ESR1, ESR2
64-octylphenol469.8ESR1, ESR2
7butylparaben469.8ESR2, ESR1
8methylparaben469.7ESR1, ESR2
9r,r-thc309.7ESR1, ESR2
10lasofoxifene469.7ESR2, ESR1
11zeranol469.6ESR1, ESR2
12crcs469.4CTNNB1, CDH1, MUC1
1312-o-tetradecanoylphorbol 13-acetate469.2CTNNA1, FGFR1, CDH1, PRLR, MUC1
14gefitinib46 52 1211.2CTNNB1, ESR2, CDH1, ESR1
15bicalutamide46 62 1211.2ESR1, ESR2, CTNNB1
16nocodazole46 1210.2HSP90AA1, CDH1, CTNNB1, CTNND1
17progestin469.1CDH1, PRLR, ESR2, ESR1, MUC1
18indole-3-carbinol469.0CTNNB1, ESR1, CDH1
194-hydroxytamoxifen469.0CTNNB1, ESR1, ESR2, HSP90AA1
20geldanamycin46 52 62 1212.0CDH1, HSP90AA1, ESR1, CTNNB1
21trastuzumab46 52 1211.0HSP90AA1, CTNNB1, MUC1, ESR1
22butyrate468.9MUC1, CDH1, PRLR, CTNNB1, HSP90AA1
23mg 13246 629.9ESR1, HSP90AA1, CDH1, CTNNB1
245-aza-2deoxycytidine468.9CTNNB1, ESR1, CDH1, ESR2, CTNNA1
25gnrh468.9ESR1, PRLR, CTNNB1, FGFR1, ESR2
26phosphotyrosine468.7FGFR1, PRLR, CDH1, CTNNA1, CTNNB1, CTNND1
275fluorouracil468.7CTNNB1, MUC1, HSP90AA1, ESR1, CDH1
28vitamin d468.7CDH1, CTNNB1, HSP90AA1, ESR2, ESR1
29mifepristone46 30 62 1211.7MUC1, ESR1, ESR2, HSP90AA1, CTNNB1
30doxorubicin46 52 1210.7HSP90AA1, ESR2, ESR1, CDH1, CTNNB1
31ly294002468.7FGFR1, CDH1, CTNNB1, ESR1, HSP90AA1
32dexamethasone46 52 30 1211.6CDH1, CTNNB1, HSP90AA1, MUC1, ESR2, PRLR
33glutamate468.6HSP90AA1, FGFR1, CTNNB1, CDH1, PRLR, ESR2
34cisplatin46 52 62 1211.6MUC1, CTNNB1, CDH1, ESR1, HSP90AA1
35threonine468.5FGFR1, HSP90AA1, MUC1, PRLR, CTNNB1, CTNND1
36dihydrotestosterone46 30 25 1211.4MUC1, ESR1, HSP90AA1, CTNNB1, ESR2, CDH1
37cysteine468.4FGFR1, CTNNB1, CDH1, PRLR, HSP90AA1, ESR2
38steroid468.3ESR1, ESR2, HSP90AA1, FGFR1, CTNNB1, PRLR
39paraffin468.2ESR2, ESR1, PRLR, CDH1, CTNNB1, CTNNA1
40genistein46 30 62 3 25 1213.1FGFR1, CDH1, PRLR, ESR1, ESR2, HSP90AA1
41retinoic acid46 259.1HSP90AA1, ESR1, MUC1, CDH1, CTNNB1, FGFR1
42tamoxifen46 52 30 1211.1CTNNB1, ESR2, CDH1, PRLR, MUC1, ESR1
43serine468.0FGFR1, HSP90AA1, ESR2, PRLR, CDH1, CTNNB1
44paclitaxel46 52 1210.0FGFR1, HSP90AA1, ESR1, CDH1, CTNNB1, CTNND1
45cycloheximide467.9CTNNB1, PRLR, ESR1, ESR2, HSP90AA1
46tyrosine467.9CTNNA1, MUC1, FGFR1, CTNND1, CTNNB1, CDH1
47progesterone46 30 62 25 1211.8ESR2, FGFR1, CTNNB1, CDH1, MUC1, HSP90AA1
48testosterone46 62 25 1210.8FGFR1, CDH1, CTNNB1, PRLR, ESR1, MUC1
49estrogen467.4HSP90AA1, ESR2, ESR1, MUC1, PRLR, CDH1
50vegf467.4FGFR1, HSP90AA1, ESR2, ESR1, MUC1, CDH1

GO Terms for genes affiliated with Lobular Neoplasia

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17Gene Ontology
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Cellular components related to Lobular Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:0098989.8CTNNB1, CDH1
2cell-cell adherens junctionGO:0059139.7CTNNB1, CDH1
3catenin complexGO:0163429.6CTNNA1, CTNNB1, CDH1
4zonula adherensGO:0059159.4CTNNB1, CTNND1, CTNNA1
5cell-cell junctionGO:0059119.3CTNNB1, CTNND1, CTNNA1
6lamellipodiumGO:0300279.2CTNNA1, CTNND1, CTNNB1
7extracellular regionGO:0055768.5HSP90AA1, ESR2, PRLR, CDH1, FGFR1
8plasma membraneGO:0058867.3HSP90AA1, ESR1, PRLR, CDH1, CTNNB1, CTNND1

Biological processes related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of protein localization to cell surfaceGO:200000810.0CTNNB1, CDH1
2lung-associated mesenchyme developmentGO:0604849.9FGFR1, CTNNB1
3positive regulation of phospholipase C activityGO:0108639.8FGFR1, ESR1
4ovarian follicle developmentGO:0015419.8CTNNA1, ESR2
5uterus developmentGO:0600659.8ESR1, ESR2
6positive regulation of muscle cell differentiationGO:0511499.8CTNNA1, CTNNB1
7vagina developmentGO:0600689.7ESR1, ESR2
8adherens junction organizationGO:0343329.7CTNNA1, CTNND1, CDH1
9cell-cell junction organizationGO:0452169.7CDH1, CTNND1, CTNNA1
10positive regulation of mesenchymal cell proliferationGO:0020539.7FGFR1, CTNNB1
11intracellular estrogen receptor signaling pathwayGO:0305209.7ESR2, ESR1
12cell junction assemblyGO:0343299.7CDH1, CTNND1, CTNNA1
13cellular response to indole-3-methanolGO:0716819.7CTNNA1, CTNNB1, CDH1
14neuron migrationGO:0017649.7ESR2, CTNNB1, FGFR1
15cell-cell adhesionGO:0163379.6CTNND1, CTNNB1, CDH1
16muscle cell differentiationGO:0426929.5CTNNA1, CTNNB1
17cell maturationGO:0484699.4FGFR1, CTNNB1
18positive regulation of nitric oxide biosynthetic processGO:0454299.4HSP90AA1, ESR1

Molecular functions related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1gamma-catenin bindingGO:0452959.8CDH1, CTNNA1
2estrogen response element bindingGO:0340569.8ESR1, ESR2
3estrogen receptor activityGO:0302849.7ESR1, ESR2
4protein phosphatase bindingGO:0199039.5CTNND1, CTNNB1, CDH1
5core promoter sequence-specific DNA bindingGO:0010469.5ESR1, ESR2
6cadherin bindingGO:0452969.5CTNNB1, CTNND1, CTNNA1
7nitric-oxide synthase regulator activityGO:0302359.4ESR1, HSP90AA1
8beta-catenin bindingGO:0080139.4ESR1, CDH1, CTNNA1
9steroid bindingGO:0054969.3ESR1, ESR2
10enzyme bindingGO:0198999.1CTNNB1, ESR1, ESR2
11protein bindingGO:0055156.3FGFR1, HSP90AA1, ESR2, ESR1, MUC1, PRLR

Products for genes affiliated with Lobular Neoplasia

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Sources for Lobular Neoplasia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet