MCID: LBL001
MIFTS: 44

Lobular Neoplasia malady

Summaries for Lobular Neoplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Lobular neoplasia can refer to: more...

MalaCards: Lobular Neoplasia, also known as lobular intraepithelial neoplasia, is related to breast cancer and ductal carcinoma in situ. An important gene associated with Lobular Neoplasia is LINS (lines homolog (Drosophila)), and among its related pathways are Adherens junction and Glioma. The compounds butyrate and 4-octylphenol have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are embryogenesis and skeleton.

Aliases & Classifications for Lobular Neoplasia

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt
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Aliases & Descriptions:

lobular neoplasia 8 10 60
lobular intraepithelial neoplasia 8


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Disease Ontology8 DOID:3010
NCIt39 C27939

Related Diseases for Lobular Neoplasia

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17GeneCards, 18GeneDecks
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Diseases related to Lobular Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.6HSP90AA1, CTNNA1, CTNND1, CTNNB1, PRLR, MUC1
2ductal carcinoma in situ30.5CDH1, ESR1
3breast fibroadenoma30.4ESR1
4gynecomastia30.1ESR1
5in situ carcinoma10.6
6breast carcinoma in situ10.5
7comedo carcinoma10.3
8small cell carcinoma10.1
9female breast carcinoma10.1
10breast disease10.1
11esophageal cancer10.0CDH1
12tongue cancer10.0PRLR
13oral cancer10.0CDH1
14leiomyosarcoma10.0MUC1
15arthritis10.0ESR2
16chordoma10.0MUC1
17cryptorchidism10.0FGFR1
18thyroid cancer10.0HSP90AA1
19desmoid tumor10.0CTNNB1
20cerebral meningioma10.0PRLR
21cystadenocarcinoma10.0MUC1
22gastrointestinal stromal tumor10.0HSP90AA1
23asthma10.0HSP90AA1
24rhabdoid tumor10.0MUC1
25pituitary adenoma10.0ESR2, PRLR
26hepatitis b10.0HSP90AA1
27fibromatosis10.0CTNNB1
28hepatitis c10.0HSP90AA1
29progesterone resistance10.0ESR1
30angiomyolipoma10.0ESR1
31wilms tumor10.0CTNNB1
32cervical cancer10.0CTNNA1
33thymoma10.0CTNNA1
34li-fraumeni syndrome10.0ESR1
35goblet cell carcinoid10.0CDH1, CTNNB1
36acute leukemia10.0FGFR1, HSP90AA1
37leiomyoma10.0ESR2, ESR1
38medulloblastoma10.0CTNNB1
39prolactinoma10.0ESR2, ESR1
40sarcoma10.0MUC1, HSP90AA1
41myeloma10.0FGFR1, HSP90AA1
42mammary paget's disease10.0MUC1, ESR1
43syringoma10.0MUC1
44endometrial stromal sarcoma10.0ESR1, ESR2
45inflammatory breast carcinoma10.0ESR1, CDH1
46rheumatoid arthritis10.0ESR2, PRLR, HSP90AA1
47synovial sarcoma10.0CDH1, MUC1, CTNNB1
48endometriosis10.0ESR2, ESR1, PRLR
49microinvasive gastric cancer10.0CTNNA1, CDH1
50malignant mixed mullerian tumor10.0MUC1, CTNNB1

Graphical network of the top 20 diseases related to Lobular Neoplasia:



Diseases related to lobular neoplasia

Clinical Features for Lobular Neoplasia

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Drugs & Therapeutics for Lobular Neoplasia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Lobular Neoplasia

Drug clinical trials:

Search ClinicalTrials for Lobular Neoplasia

Search NIH Clinical Center for Lobular Neoplasia

Search CenterWatch for Lobular Neoplasia

Genetic Tests for Lobular Neoplasia

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Anatomical Context for Lobular Neoplasia

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32MalaCards
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MalaCards organs/tissues related to Lobular Neoplasia:

32
Breast

Animal Models for Lobular Neoplasia or affiliated genes

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36MGI
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Publications for Lobular Neoplasia

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50PubMed
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Articles related to Lobular Neoplasia:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)
2013
2
Endocervical glandular neoplasia associated with lobular endocervical glandular hyperplasia is HPV-independent and correlates with carbonic anhydrase-IX expression: a Gynaecological Oncology Group Study. (23299542)
2013
3
Lobular neoplasia: what does it mean and how should it be treated? (23617527)
2013
4
Cadherin-catenin complex dissociation in lobular neoplasia of the breast. (22080244)
2012
5
Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity. (21953071)
2012
6
Lobular lesions of the breast: imaging findings of lobular neoplasia and invasive lobular carcinoma. (22324264)
2012
7
Surgical outcome of biopsy-proven lobular neoplasia: is there any difference between lobular carcinoma in situ and atypical lobular hyperplasia? (22268170)
2012
8
Is excisional biopsy required after a breast core biopsy yields lobular neoplasia? (22997389)
2012
9
Breast-specific gamma imaging in the detection of atypical ductal hyperplasia and lobular neoplasia. (22578225)
2012
10
Low frequency of cancer occurrence in same breast quadrant diagnosed with lobular neoplasia at percutaneous needle biopsy. (22344406)
2012
11
Lobular neoplasia: how to manage with partial understanding. (22106558)
2011
12
Amplification of the prolactin receptor gene in mammary lobular neoplasia. (20658264)
2011
13
Lobular neoplasia of the breast. (20701604)
2010
14
Lobular neoplasia displaying central necrosis: a potential diagnostic pitfall. (20359832)
2010
15
Lobular neoplasia: morphology, biological potential and management in core biopsies. (20436498)
2010
16
Lobular intra-epithelial neoplasia: atypical lobular hyperplasia and lobular carcinoma in situ]. (20116180)
2010
17
Lobular neoplasia: evolution of its significance and morphologic spectrum. (20484286)
2010
18
Concurrent lobular neoplasia increases the risk of ipsilateral breast cancer recurrence in patients with ductal carcinoma in situ treated with breast-conserving therapy. (19170233)
2009
19
Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. (19294736)
2009
20
Is excisional biopsy indicated for patients with lobular neoplasia diagnosed on percutaneous core needle biopsy of the breast? (19969131)
2009
21
Sampling lobular neoplasia of the breast: underestimation despite technical success? (19466452)
2009
22
Lobular neoplasia of the breast: 68 years on. (19089737)
2009
23
Lobular neoplasia of the breast: an update. (19642738)
2009
24
Lobular neoplasia: is surgical excision warranted? (18306873)
2008
25
Lobular neoplasia: core needle breast biopsy underestimation of malignancy in relation to radiologic and pathologic features. (18619840)
2008
26
Frequency and clinical significance of simultaneous association of lobular neoplasia and columnar cell alterations in breast tissue specimens. (18628095)
2008
27
Heat shock protein90 in lobular neoplasia of the breast. (18957107)
2008
28
Should the extent of lobular neoplasia on core biopsy influence the decision for excision? (17214794)
2007
29
Management of lobular neoplasia diagnosed by core needle biopsy: study of 52 biopsies with follow-up surgical excision. (17629481)
2007
30
COX-2 expression in lobular in situ neoplasia of the breast: correlation with histopathological grading system according to the Tavassoli classification. (17542993)
2007
31
The clinical significance of lobular neoplasia on breast core biopsy. (17460455)
2007
32
Immunohistochemical expression of estrogen receptors alpha and beta in lobular neoplasia. (17924141)
2007
33
Genomic alterations in lobular neoplasia: a microarray comparative genomic hybridization signature for early neoplastic proliferationin the breast. (16897748)
2006
34
Lobular neoplasia in breast core needle biopsy specimens is associated with a low risk of ductal carcinoma in situ or invasive carcinoma on subsequent excision. (16891208)
2006
35
Lobular neoplasia at 11-gauge vacuum-assisted stereotactic biopsy: correlation with surgical excisional biopsy and mammographic follow-up. (16985141)
2006
36
The evolution of lobular neoplasia. (16858149)
2006
37
Lobular Neoplasia within a Myoid Hamartoma of the Breast. (14717763)
2004
38
Lobular neoplasia on core-needle biopsy--clinical significance. (15241819)
2004
39
Cytokeratin immunoreactivity in lobular intraepithelial neoplasia. (14566024)
2003
40
The management of lobular neoplasia identified on percutaneous core breast biopsy. (12558663)
2003
41
Invasive mammary carcinoma after immediate and short-term follow-up for lobular neoplasia on core biopsy. (12604888)
2003
42
Lobular neoplasia in breast core needle biopsy specimens is not associated with an increased risk of ductal carcinoma in situ or invasive carcinoma. (12090431)
2002
43
Atypical cystic lobules in patients with lobular neoplasia. (11584316)
2001
44
Uncommon morphologic patterns of lobular neoplasia. (10459051)
1999
45
Lobular neoplasia of the breast: higher risk for subsequent invasive cancer predicted by more extensive disease. (1748429)
1991
46
C-erbB-2 oncogene protein in in situ and invasive lobular breast neoplasia. (1676930)
1991
47
Coexisting lobular neoplasia and carcinoma of the breast. (6297702)
1983
48
Lobular carcinoma in situ: (lobular neoplasia) of the breast (a symposium). (7443306)
1980
49
X-chromatin (Barr bodies) correlated with the DNA content of lobular neoplasia and invasive lobular carcinoma in the female breast. (294765)
1979
50
The nuclear DNA content of lobular neoplasia of the mammary gland. (578099)
1977

Genetic Variations for Lobular Neoplasia

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Expression for genes affiliated with Lobular Neoplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lobular Neoplasia

Search GEO for disease gene expression data for Lobular Neoplasia.

Pathways for genes affiliated with Lobular Neoplasia

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 12EMD Millipore, 55SinoBiological, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CTNND1
2
Hide members
9.9FGFR1, HSP90AA1
3
Hide members
9.8ESR2, ESR1
49.8CDH1, CTNNB1
59.8CDH1, CTNNB1
69.6CTNND1, CDH1, FGFR1
7
Development Prolactin receptor signaling
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9.6ESR2, ESR1, PRLR
89.5CTNNB1, CDH1, FGFR1
99.5CTNNA1, CTNND1, CDH1
109.5CDH1, MUC1, CTNNB1
11
Hide members
9.4ESR2, CTNNB1, HSP90AA1
12
Hide members
9.4CDH1, CTNNB1, CTNNA1
139.4CDH1, CTNNB1, CTNNA1
149.4CDH1, CTNNB1, CTNNA1
159.4CTNNA1, CTNNB1, CDH1
16
Hide members
9.4CTNNA1, CTNNB1, CDH1
179.3CTNNB1, CTNND1, CTNNA1
189.3CTNNA1, CTNND1, CTNNB1
19
Cell adhesion Endothelial cell contacts by non-junctional mechanisms
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9.3CTNNB1, CTNND1, CTNNA1
209.1CTNNB1, FGFR1, ESR1, ESR2
21
Hide members
9.0CDH1, CTNNB1, CTNND1, CTNNA1
229.0CDH1, CTNNB1, CTNND1, CTNNA1
239.0CTNNA1, CTNND1, CTNNB1, CDH1
249.0CTNNA1, CTNND1, CTNNB1, CDH1
259.0CTNNA1, CTNND1, CTNNB1, CDH1
269.0CTNNA1, CTNND1, CTNNB1, CDH1
27
Hide members
9.0CTNNA1, CTNND1, CTNNB1, CDH1
28
Development Endothelin-1/EDNRA signaling
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9.0ESR2, ESR1, CTNNB1, HSP90AA1
299.0CTNNA1, CTNND1, CTNNB1, FGFR1
30
Hide members
9.0FGFR1, CTNNB1, CTNNA1, HSP90AA1
31
Hide members
9.0CTNNA1, CTNNB1, CDH1, ESR1
32
Hide members
9.0HSP90AA1, PPP3R1, FGFR1, ESR1
338.8CTNNA1, CTNNB1, PPP3R1, CDH1
34
Hide members
8.8CTNNA1, CTNNB1, PPP3R1, CDH1
35
Hide members
8.8CTNNA1, CTNND1, CTNNB1, CDH1, FGFR1
368.8HSP90AA1, CTNNA1, CTNNB1, CDH1, FGFR1
378.7CTNNA1, CTNND1, CTNNB1, MUC1, CDH1
38
Hide members
8.4HSP90AA1, CTNNB1, PPP3R1, PRLR, CDH1, FGFR1
39
Hide members
8.0HSP90AA1, CTNNB1, PPP3R1, PRLR, CDH1, FGFR1
40
Hide members
7.9CTNNA1, CTNND1, CTNNB1, MUC1, CDH1, FGFR1

Compounds for genes affiliated with Lobular Neoplasia

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1butyrate4410.6PRLR
24-octylphenol4410.2ESR2, ESR1
3methylparaben4410.2ESR2, ESR1
44-hydroxy? tamoxifen2810.2ESR2, ESR1
517beta-estradiol2810.2ESR2, ESR1
6r,r-thc2810.2ESR2, ESR1
7(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL1110.2ESR2, ESR1
8(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL1110.2ESR2, ESR1
9(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL1110.2ESR2, ESR1
10butylparaben4410.1ESR1, ESR2
11lasofoxifene4410.1ESR1, ESR2
12isopropylparaben4410.1ESR2, ESR1
1317alpha estradiol4410.1ESR2, ESR1
14ly 1170184410.1ESR1, ESR2
15isobutylparaben4410.1ESR1, ESR2
16serine4410.0CTNND1, CDH1, ESR2
172,4,6-trichloro-4-biphenylol4410.0ESR1, ESR2
18dihydrotestosterone44 28 11 2412.9HSP90AA1, ESR1, ESR2
19paclitaxel44 49 1111.9ESR1, CDH1, CTNNB1
204-tert-octylphenol449.8ESR2, ESR1
21steroid449.8HSP90AA1, PRLR, ESR1
22dexamethasone44 49 28 1112.6CDH1, PRLR, CTNNB1
23gefitinib44 49 1111.6ESR2, ESR1, CDH1, CTNNB1
24zeranol449.5ESR2, ESR1
255fluorouracil449.5HSP90AA1, CTNNB1, MUC1, CDH1
26nocodazole44 1110.5HSP90AA1, CTNND1, CTNNB1, CDH1
274-hydroxytamoxifen449.5ESR2, ESR1, CTNNB1, HSP90AA1
28geldanamycin44 49 59 1112.5HSP90AA1, CTNNB1, CDH1, ESR1
29progestin449.5PRLR, MUC1, CDH1, ESR1, ESR2
30trastuzumab44 49 1111.4HSP90AA1, CTNNB1, MUC1, ESR1
31bicalutamide44 59 1111.4CTNNB1, ESR1, ESR2
32crcs449.4CTNNB1, MUC1, CDH1
3312-o-tetradecanoylphorbol 13-acetate449.4CTNNA1, PRLR, MUC1, CDH1, FGFR1
34gnrh449.3CTNNB1, PRLR, FGFR1, ESR1, ESR2
35vitamin d449.2HSP90AA1, CTNNB1, CDH1, ESR1, ESR2
36mifepristone44 59 28 1112.2HSP90AA1, CTNNB1, MUC1, ESR1, ESR2
375-aza-2deoxycytidine449.2CTNNA1, CTNNB1, CDH1, ESR1, ESR2
38ly294002449.2ESR1, FGFR1, CDH1, CTNNB1, HSP90AA1
39mg 13244 5910.1HSP90AA1, CTNNB1, CDH1, ESR1
40doxorubicin44 49 1111.1ESR2, ESR1, CDH1, CTNNB1, HSP90AA1
41phosphotyrosine448.9CTNNA1, CTNND1, CTNNB1, PRLR, CDH1, FGFR1
42cysteine448.7HSP90AA1, CTNNB1, PRLR, MUC1, CDH1, FGFR1
43genistein44 28 59 2 11 2413.7HSP90AA1, CTNNB1, PRLR, CDH1, FGFR1, ESR1
44tamoxifen44 49 28 1111.7HSP90AA1, CTNNB1, PRLR, MUC1, CDH1, ESR1
45retinoic acid44 249.6HSP90AA1, CTNNB1, MUC1, CDH1, FGFR1, ESR1
46paraffin448.6CTNNA1, CTNNB1, PRLR, MUC1, CDH1, ESR1
47progesterone44 59 28 11 2412.4HSP90AA1, CTNNB1, PRLR, MUC1, CDH1, FGFR1
48testosterone44 59 11 2411.4HSP90AA1, CTNNB1, PRLR, MUC1, CDH1, FGFR1
49tyrosine448.0HSP90AA1, CTNNA1, CTNND1, CTNNB1, PRLR, MUC1
50vegf448.0ESR2, HSP90AA1, CTNNA1, CTNND1, CTNNB1, MUC1

GO Terms for genes affiliated with Lobular Neoplasia

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16Gene Ontology
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Cellular components related to Lobular Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1zonula adherensGO:0059159.7CTNNB1, CTNNA1
2cell-cell adherens junctionGO:0059139.6CDH1, CTNNB1, CTNND1
3catenin complexGO:0163429.5CDH1, CTNNB1, CTNNA1
4basolateral plasma membraneGO:0163239.4CDH1, CTNNB1, HSP90AA1
5cell-cell junctionGO:0059119.3CTNNA1, CTNND1, CTNNB1
6cell surfaceGO:0099869.2CDH1, MUC1, PRLR, HSP90AA1
7lamellipodiumGO:0300279.0CTNNA1, CTNND1, CTNNB1

Biological processes related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:01086310.0ESR1, FGFR1
2regulation of protein localization to cell surfaceGO:200000810.0CDH1, CTNNB1
3uterus developmentGO:0600659.9ESR2, ESR1
4intracellular estrogen receptor signaling pathwayGO:0305209.8ESR2, ESR1
5adherens junction organizationGO:0343329.7CTNNA1, CTNND1, CDH1
6cell-cell junction organizationGO:0452169.7CTNNA1, CTNND1, CDH1
7lung-associated mesenchyme developmentGO:0604849.7FGFR1, CTNNB1
8cellular response to indole-3-methanolGO:0716819.6CDH1, CTNNB1, CTNNA1
9cell junction assemblyGO:0343299.6CDH1, CTNND1, CTNNA1
10response to estrogen stimulusGO:0436279.6ESR1, CTNNA1, HSP90AA1
11vagina developmentGO:0600689.5ESR2, ESR1
12cell-cell adhesionGO:0163379.5CTNND1, CTNNB1, CDH1
13neuron migrationGO:0017649.4ESR2, FGFR1, CTNNB1, HSP90AA1

Molecular functions related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:03405610.0ESR2, ESR1
2estrogen receptor activityGO:0302849.9ESR1, ESR2
3gamma-catenin bindingGO:0452959.8CDH1, CTNNA1
4nitric-oxide synthase regulator activityGO:0302359.7HSP90AA1, ESR1
5core promoter sequence-specific DNA bindingGO:0010469.5ESR2, ESR1
6cadherin bindingGO:0452969.5CTNNA1, CTNND1, CTNNB1
7beta-catenin bindingGO:0080139.5ESR1, CDH1, CTNNA1
8protein phosphatase bindingGO:0199039.3CDH1, CTNNB1, CTNND1, HSP90AA1
9protein bindingGO:0055156.0HSP90AA1, CTNNA1, CTNND1, CTNNB1, PPP3R1, PRLR

Products for genes affiliated with Lobular Neoplasia

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  • Antibodies
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Sources for Lobular Neoplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet