Aliases & Classifications for Lobular Neoplasia

MalaCards integrated aliases for Lobular Neoplasia:

Name: Lobular Neoplasia 12 14 69
Lobular Carcinoma in Situ of Breast 69
Non-Infiltrating Lobular Carcinoma 69
Lobular Intraepithelial Neoplasia 12
Lobular Carcinoma in Situ 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3010
NCIt 46 C27939
ICD10 32 D05.0

Summaries for Lobular Neoplasia

MalaCards based summary : Lobular Neoplasia, also known as lobular carcinoma in situ of breast, is related to ductal carcinoma in situ and breast cancer. An important gene associated with Lobular Neoplasia is CDH1 (Cadherin 1), and among its related pathways/superpathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. Affiliated tissues include breast, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and cellular

Wikipedia : 72 Lobular neoplasia can refer... more...

Related Diseases for Lobular Neoplasia

Diseases related to Lobular Neoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 ductal carcinoma in situ 28.8 BRCA1 CDH1 ERBB2 ESR1 MUC1
2 breast cancer 26.9 BRCA1 CDH1 CTNNB1 ERBB2 ESR1 ESR2
3 gastric signet ring cell adenocarcinoma 10.4 CDH1 ESR1
4 progesterone resistance 10.4 ESR1 ESR2
5 large intestine adenocarcinoma 10.4 CDH1 CTNNB1
6 goblet cell carcinoid 10.4 CDH1 CTNNB1
7 gender identity disorder 10.4 ESR1 ESR2
8 estrogen excess 10.4 ESR1 ESR2
9 dental fluorosis 10.4 ESR1 ESR2
10 endometriosis of ovary 10.3 ESR1 ESR2
11 vaginitis 10.3 ESR1 ESR2
12 gastric cancer, hereditary diffuse 10.3 CDH1 CTNNA1
13 gastric diffuse adenocarcinoma 10.3 CDH1 CTNNA1
14 synchronous bilateral breast carcinoma 10.3 BRCA1 ESR1
15 microinvasive gastric cancer 10.3 CDH1 CTNNA1
16 glycogen-rich clear cell breast carcinoma 10.2 BRCA1 ESR1
17 biphasic synovial sarcoma 10.2 CDH1 MUC1
18 endometrial mucinous adenocarcinoma 10.2 ESR1 MUC1
19 parotid gland cancer 10.2 CDH1 ESR2
20 syringoma 10.2 ESR1 MUC1
21 postmenopausal atrophic vaginitis 10.2 ESR1 ESR2 PRLR
22 chondroid chordoma 10.2 CDH1 MUC1
23 adenomyoma 10.2 CTNNB1 MUC1
24 pelvic organ prolapse 10.1 ESR1 ESR2
25 tongue cancer 10.1 CDH1 CTNNB1 PRLR
26 thyroid cancer, nonmedullary, 1 10.1 CDH1 CTNNB1 ESR2
27 lymphoepithelioma-like carcinoma 10.1 CDH1 MUC1
28 breast cystic hypersecretory carcinoma 10.1 CDH1 ERBB2
29 glassy cell carcinoma of the cervix 10.1 ERBB2 ESR1
30 peritoneal mesothelioma 10.1 ESR1 MUC1
31 comedo carcinoma 10.1 ERBB2 ESR1
32 sclerosing hemangioma 10.1 CTNNB1 MUC1
33 oncocytic breast carcinoma 10.1 ERBB2 ESR1
34 pancreatic mucinous cystadenoma 10.1 ESR1 MUC1
35 breast squamous cell carcinoma 10.1 CDH1 ERBB2
36 breast adenoid cystic carcinoma 10.0 ERBB2 ESR1
37 uterine body mixed cancer 10.0 ERBB2 ESR2
38 epstein-barr virus-associated gastric carcinoma 10.0 CDH1 CTNNB1
39 luminal breast carcinoma 10.0 ERBB2 ESR1
40 breast benign neoplasm 10.0 ERBB2 ESR1
41 thoracic benign neoplasm 10.0 ERBB2 ESR1
42 polymorphous low-grade adenocarcinoma 10.0 CTNNB1 MUC1
43 signet ring cell adenocarcinoma 10.0 CDH1 CTNNB1 MUC1
44 uterine corpus cancer 10.0 ERBB2 ESR1
45 pancreas adenocarcinoma 10.0 CDH1 CTNNB1 MUC1
46 sarcoma, synovial 10.0 CDH1 CTNNB1 MUC1
47 diffuse gastric cancer 10.0 CDH1 CTNNA1
48 mesothelioma, malignant 10.0 CDH1 CTNNB1 MUC1
49 intrahepatic cholangiocarcinoma 10.0 CDH1 CTNNB1 MUC1
50 breast fibroadenoma 10.0

Graphical network of the top 20 diseases related to Lobular Neoplasia:



Diseases related to Lobular Neoplasia

Symptoms & Phenotypes for Lobular Neoplasia

GenomeRNAi Phenotypes related to Lobular Neoplasia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 8.92 CTNNA1 CTNNB1 ERBB2 MUC1

MGI Mouse Phenotypes related to Lobular Neoplasia:

43 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.19 ERBB2 ESR2 ESR1 HSP90AA1 CTNNA1 BRCA1
2 endocrine/exocrine gland MP:0005379 10.15 ESR2 ESR1 HSP90AA1 ERBB2 CTNNA1 BRCA1
3 growth/size/body region MP:0005378 10.13 ERBB2 ESR2 ESR1 HSP90AA1 CTNNA1 BRCA1
4 behavior/neurological MP:0005386 10.1 ERBB2 ESR2 HSP90AA1 ESR1 BRCA1 CTNNB1
5 cardiovascular system MP:0005385 10.09 ERBB2 ESR2 ESR1 CTNNA1 BRCA1 CTNNB1
6 integument MP:0010771 10.06 ESR2 ESR1 ERBB2 CTNNA1 BRCA1 CTNNB1
7 embryo MP:0005380 10.05 ERBB2 ESR1 CTNNA1 BRCA1 CTNNB1 CDH1
8 limbs/digits/tail MP:0005371 10.03 ESR2 ESR1 HSP90AA1 PRLR ERBB2 CTNNA1
9 mortality/aging MP:0010768 10.01 ERBB2 ESR2 HSP90AA1 ESR1 CDH1 CTNNA1
10 digestive/alimentary MP:0005381 10 ERBB2 ESR2 ESR1 BRCA1 CTNNB1 CDH1
11 neoplasm MP:0002006 9.92 ESR2 ESR1 PRLR ERBB2 CTNNA1 BRCA1
12 muscle MP:0005369 9.85 ERBB2 ESR2 ESR1 CTNNA1 BRCA1 CTNNB1
13 nervous system MP:0003631 9.8 ERBB2 ESR2 ESR1 CTNNB1 CTNNA1 BRCA1
14 normal MP:0002873 9.63 ERBB2 ESR2 ESR1 BRCA1 CTNNB1 CDH1
15 reproductive system MP:0005389 9.56 ERBB2 ESR2 ESR1 HSP90AA1 BRCA1 CTNNB1
16 skeleton MP:0005390 9.23 ERBB2 ESR2 ESR1 HSP90AA1 CTNNA1 BRCA1

Drugs & Therapeutics for Lobular Neoplasia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Upstaging of ALH/LCIS Found on Core Biopsy Based on Subsequent Excisional Biopsy Completed NCT00146536

Search NIH Clinical Center for Lobular Neoplasia

Genetic Tests for Lobular Neoplasia

Anatomical Context for Lobular Neoplasia

MalaCards organs/tissues related to Lobular Neoplasia:

38
Breast

Publications for Lobular Neoplasia

Articles related to Lobular Neoplasia:

(show top 50) (show all 90)
# Title Authors Year
1
Observation versus excision of lobular neoplasia on core needle biopsy of the breast. ( 29299726 )
2018
2
Sonographic Appearance of Lesions Diagnosed as Lobular Neoplasia at Sonographically Guided Biopsies. ( 28075608 )
2017
3
Is the outcome at surgery different when flat epithelial atypia and lobular neoplasia are found in association at biopsy? ( 28118035 )
2017
4
Lobular Neoplasia and Atypical Ductal Hyperplasia on Core Biopsy: Current Surgical Management Recommendations. ( 28766203 )
2017
5
Surgical Outcomes of Lobular Neoplasia Diagnosed in Core Biopsy: Prospective Study ofA 316 Cases. ( 27425222 )
2016
6
CD10-positive myoepithelial cells are usually prominent around in situ lobular neoplasia of the breast and much less prominent or absent in DCIS. ( 26862059 )
2016
7
When pathological and radiological correlation is achieved, excision of fibroadenoma with lobular neoplasia on core biopsy is not warranted. ( 27718416 )
2016
8
The radiological features, diagnosis and management of screen-detected lobular neoplasia of the breast: Findings from the Sloane Project. ( 27060553 )
2016
9
Lobular neoplasia diagnosed on breast Core biopsy: frequency of carcinoma on excision and implications for management. ( 27806840 )
2016
10
Lobular neoplasia detected in MRI-guided core biopsy carries a high risk for upgrade: a study of 63 cases from four different institutions. ( 26564004 )
2016
11
Lobular Neoplasia: Another Reset in Management? ( 26676981 )
2016
12
Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In-situ in Patients with Lobular Neoplasia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 020). ( 26542585 )
2015
13
Lobular neoplasia of the breast revisited with emphasis on the role of E-cadherin immunohistochemistry. ( 24441664 )
2014
14
Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast. ( 24948027 )
2014
15
Evolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methods. ( 24633840 )
2014
16
Mucinous breast carcinoma with a lobular neoplasia component: a subset with aberrant expression of cell adhesion and polarity molecules and lack of neuroendocrine differentiation. ( 24888775 )
2014
17
Lobular neoplasia: morphology and management. ( 25268198 )
2014
18
Lobular neoplasia. ( 24882347 )
2014
19
Lobular neoplasia: what does it mean and how should it be treated? ( 23617527 )
2013
20
Lobular neoplasia of the breast revisited with emphasis on the role of E-cadherin immunohistochemistry. ( 23759937 )
2013
21
Classic lobular neoplasia on core biopsy: a clinical and radio-pathologic correlation study with follow-up excision biopsy. ( 23307062 )
2013
22
Is excisional biopsy required after a breast core biopsy yields lobular neoplasia? ( 22997389 )
2012
23
Low frequency of cancer occurrence in same breast quadrant diagnosed with lobular neoplasia at percutaneous needle biopsy. ( 22344406 )
2012
24
Cadherin-catenin complex dissociation in lobular neoplasia of the breast. ( 22080244 )
2012
25
Lobular lesions of the breast: imaging findings of lobular neoplasia and invasive lobular carcinoma. ( 22324264 )
2012
26
Surgical outcome of biopsy-proven lobular neoplasia: is there any difference between lobular carcinoma in situ and atypical lobular hyperplasia? ( 22268170 )
2012
27
Pathologic findings of follow-up surgical excision for lobular neoplasia on breast core biopsy performed for calcification. ( 22706860 )
2012
28
Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity. ( 21953071 )
2012
29
Breast-specific gamma imaging in the detection of atypical ductal hyperplasia and lobular neoplasia. ( 22578225 )
2012
30
Long-term follow-up of lobular neoplasia (atypical lobular hyperplasia/lobular carcinoma in situ) diagnosed on core needle biopsy. ( 22847124 )
2012
31
Lobular neoplasia: how to manage with partial understanding. ( 22106558 )
2011
32
Amplification of the prolactin receptor gene in mammary lobular neoplasia. ( 20658264 )
2011
33
Lobular neoplasia found on breast biopsy: marker of increased risk of malignancy or direct pre-cancerous lesion? ( 22038220 )
2011
34
In situ lobular neoplasia of the breast with marked myoepithelial proliferation. ( 21707709 )
2011
35
Lobular neoplasia: frequency and association with other breast lesions. ( 21827679 )
2011
36
Lobular neoplasia: morphology, biological potential and management in core biopsies. ( 20436498 )
2010
37
Management of in situ lobular neoplasia detected on needle core biopsy of breast. ( 20972243 )
2010
38
Lobular neoplasia: evolution of its significance and morphologic spectrum. ( 20484286 )
2010
39
Lobular neoplasia displaying central necrosis: a potential diagnostic pitfall. ( 20359832 )
2010
40
Lobular neoplasia of the breast. ( 20701604 )
2010
41
Lobular neoplasia of the breast: 68 years on. ( 19089737 )
2009
42
Concurrent lobular neoplasia increases the risk of ipsilateral breast cancer recurrence in patients with ductal carcinoma in situ treated with breast-conserving therapy. ( 19170233 )
2009
43
Sampling lobular neoplasia of the breast: underestimation despite technical success? ( 19466452 )
2009
44
Lobular neoplasia of the breast: an update. ( 19642738 )
2009
45
Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. ( 19294736 )
2009
46
Is excisional biopsy indicated for patients with lobular neoplasia diagnosed on percutaneous core needle biopsy of the breast? ( 19969131 )
2009
47
Heat shock protein90 in lobular neoplasia of the breast. ( 18957107 )
2008
48
Frequency and clinical significance of simultaneous association of lobular neoplasia and columnar cell alterations in breast tissue specimens. ( 18628095 )
2008
49
Lobular neoplasia in vacuum-assisted breast biopsy: extended protocols and underestimation. ( 18356422 )
2008
50
Lobular neoplasia on core needle biopsy does not require excision. ( 18348299 )
2008

Variations for Lobular Neoplasia

Cosmic variations for Lobular Neoplasia:

9 (show top 50) (show all 117)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM638 WNK1 breast,NS,carcinoma,lobular carcinoma c.1255G>C p.E419Q 7
2 COSM637 WNK1 breast,NS,carcinoma,lobular carcinoma c.6569C>G p.S2190C 7
3 COSM17721 VHL breast,NS,carcinoma,lobular carcinoma c.241C>T p.P81S 7
4 COSM51319 USP28 breast,NS,carcinoma,lobular carcinoma c.2050G>A p.D684N 7
5 COSM6188 TRIM33 breast,NS,carcinoma,lobular carcinoma c.2968-1G>C p.? 7
6 COSM10722 TP53 breast,NS,carcinoma,lobular carcinoma c.853G>A p.E285K 7
7 COSM10768 TP53 breast,NS,carcinoma,lobular carcinoma c.535C>T p.H179Y 7
8 COSM43606 TP53 breast,NS,carcinoma,lobular carcinoma c.734G>A p.G245D 7
9 COSM43695 TP53 breast,NS,carcinoma,lobular carcinoma c.748C>T p.P250S 7
10 COSM11552 TP53 breast,NS,carcinoma,lobular carcinoma c.775G>T p.D259Y 7
11 COSM10648 TP53 breast,NS,carcinoma,lobular carcinoma c.524G>A p.R175H 7
12 COSM10728 TP53 breast,NS,carcinoma,lobular carcinoma c.839G>A p.R280K 7
13 COSM10726 TP53 breast,NS,carcinoma,lobular carcinoma c.856G>A p.E286K 7
14 COSM11196 TP53 breast,NS,carcinoma,lobular carcinoma c.734G>T p.G245V 7
15 COSM6165 STK32B breast,NS,carcinoma,lobular carcinoma c.910-1G>C p.? 7
16 COSM629 STK32B breast,NS,carcinoma,lobular carcinoma c.940G>T p.E314* 7
17 COSM649 SNRK breast,NS,carcinoma,lobular carcinoma c.2295C>G p.I765M 7
18 COSM647 SMG1 breast,NS,carcinoma,lobular carcinoma c.6500C>G p.S2167C 7
19 COSM6160 SMG1 breast,NS,carcinoma,lobular carcinoma c.5932C>T p.Q1978* 7
20 COSM84438 SMAD4 breast,NS,carcinoma,lobular carcinoma c.247C>T p.Q83* 7
21 COSM6162 SGK494 breast,NS,carcinoma,lobular carcinoma c.836G>A p.R279Q 7
22 COSM646 SGK2 breast,NS,carcinoma,lobular carcinoma c.381G>A p.Q127Q 7
23 COSM51308 RNASEH2A breast,NS,carcinoma,lobular carcinoma c.872G>A p.R291H 7
24 COSM1659143 RB1 breast,NS,carcinoma,lobular carcinoma c.2077G>T p.E693* 7
25 COSM775 PIK3CA breast,NS,carcinoma,lobular carcinoma c.3140A>G p.H1047R 7
26 COSM764 PIK3CA breast,NS,carcinoma,lobular carcinoma c.1634A>G p.E545G 7
27 COSM763 PIK3CA breast,NS,carcinoma,lobular carcinoma c.1633G>A p.E545K 7
28 COSM760 PIK3CA breast,NS,carcinoma,lobular carcinoma c.1624G>A p.E542K 7
29 COSM12592 PIK3CA breast,NS,carcinoma,lobular carcinoma c.3132T>A p.N1044K 7
30 COSM757 PIK3CA breast,NS,carcinoma,lobular carcinoma c.1258T>C p.C420R 7
31 COSM776 PIK3CA breast,NS,carcinoma,lobular carcinoma c.3140A>T p.H1047L 7
32 COSM762 PIK3CA breast,NS,carcinoma,lobular carcinoma c.1625A>T p.E542V 7
33 COSM746 PIK3CA breast,NS,carcinoma,lobular carcinoma c.263G>A p.R88Q 7
34 COSM648 NUAK2 breast,NS,carcinoma,lobular carcinoma c.1622G>A p.G541E 7
35 COSM612 NTRK3 breast,NS,carcinoma,lobular carcinoma c.2033G>A p.R678Q 7
36 COSM611 NPR1 breast,NS,carcinoma,lobular carcinoma c.809T>G p.F270C 7
37 COSM51304 MYH8 breast,NS,carcinoma,lobular carcinoma c.2640G>C p.M880I 7
38 COSM51313 MORC1 breast,NS,carcinoma,lobular carcinoma c.698C>T p.A233V 7
39 COSM640 MOK breast,NS,carcinoma,lobular carcinoma c.816G>C p.E272D 7
40 COSM1659156 MEN1 breast,NS,carcinoma,lobular carcinoma c.496C>T p.Q166* 7
41 COSM12780 MAP3K19 breast,NS,carcinoma,lobular carcinoma c.1500C>G p.I500M 7
42 COSM607 MAP3K12 breast,NS,carcinoma,lobular carcinoma c.1225G>A p.E409K 7
43 COSM1659155 MAP2K4 breast,NS,carcinoma,lobular carcinoma c.513+2T>C p.? 7
44 COSM605 LYN breast,NS,carcinoma,lobular carcinoma c.1153G>T p.D385Y 7
45 COSM518 KRAS breast,NS,carcinoma,lobular carcinoma c.34G>C p.G12R 7
46 COSM527 KRAS breast,NS,carcinoma,lobular carcinoma c.37G>T p.G13C 7
47 COSM1272082 KIT breast,NS,carcinoma,lobular carcinoma c.1262T>A p.L421H 7
48 COSM51331 KIF1C breast,NS,carcinoma,lobular carcinoma c.873G>A p.K291K 7
49 COSM51330 KIAA1468 breast,NS,carcinoma,lobular carcinoma c.2081G>A p.R694K 7
50 COSM51299 HAUS3 breast,NS,carcinoma,lobular carcinoma c.1657G>A p.V553M 7

Expression for Lobular Neoplasia

Search GEO for disease gene expression data for Lobular Neoplasia.

Pathways for Lobular Neoplasia

Pathways related to Lobular Neoplasia according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 BRCA1 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1
2
Show member pathways
13.09 CDH1 CTNNB1 ERBB2 ESR1 ESR2 HSP90AA1
3
Show member pathways
12.79 BRCA1 CDH1 CTNNA1 CTNNB1 ERBB2 HSP90AA1
4
Show member pathways
12.54 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1
5
Show member pathways
12.42 ERBB2 ESR1 ESR2 HSP90AA1
6
Show member pathways
12.34 ERBB2 ESR1 ESR2 PRLR
7
Show member pathways
12.26 BRCA1 CTNNB1 ESR1 HSP90AA1
8 12.22 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1 ESR2
9
Show member pathways
12.21 CDH1 CTNNB1 ERBB2 HSP90AA1 MUC1
10
Show member pathways
12.17 ERBB2 ESR1 ESR2
11 12.15 CTNNB1 ERBB2 ESR1
12
Show member pathways
12.11 CDH1 CTNNA1 CTNNB1
13
Show member pathways
12.06 CTNNA1 CTNNB1 HSP90AA1
14 11.99 CDH1 CTNNA1 CTNNB1
15 11.97 BRCA1 CDH1 CTNNB1 ESR1
16 11.94 CDH1 CTNNA1 CTNNB1
17
Show member pathways
11.83 BRCA1 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1
18
Show member pathways
11.81 ERBB2 ESR1 PRLR
19 11.75 CDH1 CTNNA1 CTNNB1 MUC1
20 11.64 CDH1 CTNNA1 CTNNB1
21 11.37 CDH1 CTNNA1 CTNNB1
22 11.31 CDH1 CTNNA1 CTNNB1
23 11.31 CDH1 CTNNA1 CTNNB1 ERBB2
24 11.3 CDH1 CTNNA1 CTNNB1
25 11.21 ESR1 HSP90AA1
26 11.2 CTNNA1 CTNNB1
27 11.18 CTNNA1 CTNNB1
28 11.18 ESR2 PRLR
29 11.17 CDH1 CTNNA1 CTNNB1
30 11.16 CDH1 ERBB2
31 11.15 CDH1 CTNNA1 CTNNB1
32 11.14 CTNNB1 ERBB2
33 11.1 ESR1 ESR2
34 11.07 ESR1 ESR2
35 11.04 ESR1 HSP90AA1
36 11 ESR1 ESR2
37 10.98 CDH1 CTNNA1 CTNNB1
38 10.9 CDH1 CTNNA1
39 10.55 CDH1 CTNNA1 CTNNB1
40 10.16 ESR1 ESR2

GO Terms for Lobular Neoplasia

Cellular components related to Lobular Neoplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.91 BRCA1 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1
2 protein complex GO:0043234 9.71 BRCA1 CTNNB1 ESR1 HSP90AA1
3 lamellipodium GO:0030027 9.54 CDH1 CTNNA1 CTNNB1
4 cell-cell adherens junction GO:0005913 9.33 CDH1 CTNNA1 CTNNB1
5 apical junction complex GO:0043296 9.32 CDH1 CTNNB1
6 catenin complex GO:0016342 9.13 CDH1 CTNNA1 CTNNB1
7 flotillin complex GO:0016600 8.8 CDH1 CTNNA1 CTNNB1

Biological processes related to Lobular Neoplasia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.83 BRCA1 CTNNB1 ERBB2 ESR1
2 regulation of cell proliferation GO:0042127 9.73 BRCA1 CTNNA1 CTNNB1
3 regulation of angiogenesis GO:0045765 9.55 CTNNB1 ERBB2
4 positive regulation of transcription, DNA-templated GO:0045893 9.55 BRCA1 CDH1 CTNNB1 ESR1 ESR2
5 positive regulation of telomerase activity GO:0051973 9.54 CTNNB1 HSP90AA1
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.54 CTNNB1 ESR1 ESR2
7 positive regulation of muscle cell differentiation GO:0051149 9.51 CTNNA1 CTNNB1
8 intracellular estrogen receptor signaling pathway GO:0030520 9.49 ESR1 ESR2
9 mammary gland alveolus development GO:0060749 9.48 ESR1 PRLR
10 positive regulation of histone H3-K4 methylation GO:0051571 9.46 BRCA1 CTNNB1
11 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.43 BRCA1 MUC1
12 response to estrogen GO:0043627 9.43 BRCA1 CTNNA1 ESR1
13 entry of bacterium into host cell GO:0035635 9.4 CDH1 CTNNB1
14 regulation of epithelial cell differentiation GO:0030856 9.32 CTNNB1 PRLR
15 adherens junction organization GO:0034332 9.13 CDH1 CTNNA1 CTNNB1
16 cellular response to indole-3-methanol GO:0071681 8.92 BRCA1 CDH1 CTNNA1 CTNNB1

Molecular functions related to Lobular Neoplasia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.73 BRCA1 CTNNB1 ESR1 ESR2
2 identical protein binding GO:0042802 9.63 CDH1 CTNNA1 ERBB2 ESR1 ESR2 HSP90AA1
3 beta-catenin binding GO:0008013 9.54 CDH1 CTNNA1 ESR1
4 disordered domain specific binding GO:0097718 9.49 CTNNB1 HSP90AA1
5 steroid binding GO:0005496 9.46 ESR1 ESR2
6 gamma-catenin binding GO:0045295 9.4 CDH1 CTNNA1
7 nitric-oxide synthase regulator activity GO:0030235 9.32 ESR1 HSP90AA1
8 estrogen receptor activity GO:0030284 9.26 ESR1 ESR2
9 estrogen response element binding GO:0034056 8.96 ESR1 ESR2
10 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.62 ESR1 ESR2
11 protein binding GO:0005515 10.18 BRCA1 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1

Sources for Lobular Neoplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....