MCID: LBL001
MIFTS: 44

Lobular Neoplasia malady

Summaries for Lobular Neoplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Lobular neoplasia can refer to: more...

MalaCards: Lobular Neoplasia, also known as lobular intraepithelial neoplasia, is related to breast cancer and ductal carcinoma in situ. An important gene associated with Lobular Neoplasia is LINS (lines homolog (Drosophila)), and among its related pathways are Adherens junction and Glioma. The compounds butyrate and butylparaben have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are embryogenesis and skeleton.

Aliases & Classifications for Lobular Neoplasia

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt
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Aliases & Descriptions:

lobular neoplasia 8 10 60
lobular intraepithelial neoplasia 8


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Disease Ontology8 DOID:3010
NCIt39 C27939

Related Diseases for Lobular Neoplasia

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17GeneCards, 18GeneDecks
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Diseases related to Lobular Neoplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.6HSP90AA1, CTNNA1, CTNND1, CTNNB1, PRLR, MUC1
2ductal carcinoma in situ30.5CDH1, ESR1
3breast fibroadenoma30.4ESR1
4gynecomastia30.1ESR1
5in situ carcinoma10.6
6breast carcinoma in situ10.5
7comedo carcinoma10.3
8small cell carcinoma10.1
9female breast carcinoma10.1
10breast disease10.1
11esophageal cancer10.0CDH1
12tongue cancer10.0PRLR
13oral cancer10.0CDH1
14leiomyosarcoma10.0MUC1
15arthritis10.0ESR2
16chordoma10.0MUC1
17cryptorchidism10.0FGFR1
18thyroid cancer10.0HSP90AA1
19desmoid tumor10.0CTNNB1
20cerebral meningioma10.0PRLR
21cystadenocarcinoma10.0MUC1
22gastrointestinal stromal tumor10.0HSP90AA1
23asthma10.0HSP90AA1
24rhabdoid tumor10.0MUC1
25pituitary adenoma10.0ESR2, PRLR
26hepatitis b10.0HSP90AA1
27fibromatosis10.0CTNNB1
28hepatitis c10.0HSP90AA1
29progesterone resistance10.0ESR1
30angiomyolipoma10.0ESR1
31wilms tumor10.0CTNNB1
32cervical cancer10.0CTNNA1
33thymoma10.0CTNNA1
34li-fraumeni syndrome10.0ESR1
35goblet cell carcinoid10.0CDH1, CTNNB1
36acute leukemia10.0FGFR1, HSP90AA1
37leiomyoma10.0ESR2, ESR1
38medulloblastoma10.0CTNNB1
39prolactinoma10.0ESR2, ESR1
40sarcoma10.0MUC1, HSP90AA1
41myeloma10.0FGFR1, HSP90AA1
42mammary paget's disease10.0MUC1, ESR1
43syringoma10.0MUC1
44endometrial stromal sarcoma10.0ESR1, ESR2
45inflammatory breast carcinoma10.0ESR1, CDH1
46rheumatoid arthritis10.0ESR2, PRLR, HSP90AA1
47synovial sarcoma10.0CDH1, MUC1, CTNNB1
48endometriosis10.0ESR2, ESR1, PRLR
49microinvasive gastric cancer10.0CTNNA1, CDH1
50malignant mixed mullerian tumor10.0MUC1, CTNNB1

Graphical network of the top 20 diseases related to Lobular Neoplasia:



Diseases related to lobular neoplasia

Clinical Features for Lobular Neoplasia

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Drugs & Therapeutics for Lobular Neoplasia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Lobular Neoplasia

Drug clinical trials:

Search ClinicalTrials for Lobular Neoplasia

Search NIH Clinical Center for Lobular Neoplasia

Search CenterWatch for Lobular Neoplasia

Genetic Tests for Lobular Neoplasia

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Anatomical Context for Lobular Neoplasia

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32MalaCards
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MalaCards organs/tissues related to Lobular Neoplasia:

32
Breast

Animal Models for Lobular Neoplasia or affiliated genes

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36MGI
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Publications for Lobular Neoplasia

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50PubMed
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Articles related to Lobular Neoplasia:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)
2013
2
Classic lobular neoplasia on core biopsy: a clinical and radio-pathologic correlation study with follow-up excision biopsy. (23307062)
2013
3
Endocervical glandular neoplasia associated with lobular endocervical glandular hyperplasia is HPV-independent and correlates with carbonic anhydrase-IX expression: a Gynaecological Oncology Group Study. (23299542)
2013
4
Lobular neoplasia of the breast revisited with emphasis on the role of E-cadherin immunohistochemistry. (23759937)
2013
5
Lobular neoplasia: what does it mean and how should it be treated? (23617527)
2013
6
Long-term follow-up of lobular neoplasia (atypical lobular hyperplasia/lobular carcinoma in situ) diagnosed on core needle biopsy. (22847124)
2012
7
Cadherin-catenin complex dissociation in lobular neoplasia of the breast. (22080244)
2012
8
Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity. (21953071)
2012
9
Pathologic findings of follow-up surgical excision for lobular neoplasia on breast core biopsy performed for calcification. (22706860)
2012
10
Breast-specific gamma imaging in the detection of atypical ductal hyperplasia and lobular neoplasia. (22578225)
2012
11
In situ lobular neoplasia of the breast with marked myoepithelial proliferation. (21707709)
2011
12
Lobular neoplasia: frequency and association with other breast lesions. (21827679)
2011
13
Amplification of the prolactin receptor gene in mammary lobular neoplasia. (20658264)
2011
14
Lobular neoplasia found on breast biopsy: marker of increased risk of malignancy or direct pre-cancerous lesion? (22038220)
2011
15
Lobular neoplasia of the breast. (20701604)
2010
16
Management of in situ lobular neoplasia detected on needle core biopsy of breast. (20972243)
2010
17
Lobular neoplasia: morphology, biological potential and management in core biopsies. (20436498)
2010
18
Lobular intra-epithelial neoplasia: atypical lobular hyperplasia and lobular carcinoma in situ]. (20116180)
2010
19
Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. (19294736)
2009
20
Lobular neoplasia in vacuum-assisted breast biopsy: extended protocols and underestimation. (18356422)
2008
21
Interobserver variability and aberrant E-cadherin immunostaining of lobular neoplasia and infiltrating lobular carcinoma. (18587329)
2008
22
Lobular neoplasia: core needle breast biopsy underestimation of malignancy in relation to radiologic and pathologic features. (18619840)
2008
23
In situ and invasive lobular neoplasia of the breast. (18171417)
2008
24
Lobular neoplasia on core needle biopsy does not require excision. (18348299)
2008
25
Frequency and clinical significance of simultaneous association of lobular neoplasia and columnar cell alterations in breast tissue specimens. (18628095)
2008
26
Lobular neoplasia at percutaneous breast biopsy: variables associated with carcinoma at surgical excision. (18287433)
2008
27
Non-operative breast pathology: lobular neoplasia. (17182661)
2007
28
Wider excision following core biopsies of lobular neoplasia. (17983415)
2007
29
Flat epithelial atypia (DIN 1a, atypical columnar change): an underdiagnosed entity very frequently coexisting with lobular neoplasia. (17543075)
2007
30
High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma. (17325484)
2007
31
Lobular neoplasia diagnosed at core biopsy does not mandate surgical excision. (17662303)
2007
32
The clinical significance of lobular neoplasia on breast core biopsy. (17460455)
2007
33
COX-2 localization within plasma membrane caveolae-like structures in human lobular intraepithelial neoplasia of the breast. (17851687)
2007
34
Genomic alterations in lobular neoplasia: a microarray comparative genomic hybridization signature for early neoplastic proliferationin the breast. (16897748)
2006
35
Lobular intraepithelial neoplasia [lobular carcinoma in situ] with comedo-type necrosis: A clinicopathologic study of 18 cases. (17063087)
2006
36
Evolving concepts in the management of lobular neoplasia. (16687097)
2006
37
The evolution of lobular neoplasia. (16858149)
2006
38
Lobular neoplasia on core-needle biopsy--clinical significance. (15481097)
2004
39
Lobular neoplasia on core-needle biopsy--clinical significance. (15241819)
2004
40
In-situ lobular neoplasia: time for an awakening. (12531570)
2003
41
Atypical cystic lobules in patients with lobular neoplasia. (11584316)
2001
42
Lobular neoplasia. Long term risk of breast cancer and relation to other factors. (8780540)
1996
43
Gynecomastia with unusual intraductal "clear cell" changes mimicking pagetoid ductal spread of lobular neoplasia. (7567685)
1995
44
Lobular neoplasia: a risk factor for cancer of the breast. (7071216)
1982
45
Lobular carcinoma in situ: (lobular neoplasia) of the breast (a symposium). (7443306)
1980
46
Lobular neoplasia (lobular carcinoma in situ) of the breast - a histological entity of controversial clinical significance. (7433225)
1980
47
Morphometric and cytophotometric investigations of lobular neoplasia of the breast with ductal involvement. (468888)
1979
48
Lobular neoplasia (so-called lobular carcinoma in situ) of the breast. (209887)
1978
49
The nuclear DNA content of lobular neoplasia of the mammary gland. (578099)
1977
50
Neoplastic proliferation of the epithelium of the mammary lobules: adenosis, lobular neoplasia, and small cell carcinoma. (5020552)
1972

Genetic Variations for Lobular Neoplasia

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Expression for genes affiliated with Lobular Neoplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lobular Neoplasia

Search GEO for disease gene expression data for Lobular Neoplasia.

Pathways for genes affiliated with Lobular Neoplasia

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 12EMD Millipore, 55SinoBiological, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CTNND1
2
Hide members
9.9FGFR1, HSP90AA1
3
Hide members
9.8ESR2, ESR1
49.8CDH1, CTNNB1
59.8CDH1, CTNNB1
69.6CTNND1, CDH1, FGFR1
7
Development Prolactin receptor signaling
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9.6ESR2, ESR1, PRLR
89.5CTNNB1, CDH1, FGFR1
99.5CTNNA1, CTNND1, CDH1
109.5CDH1, MUC1, CTNNB1
11
Hide members
9.4ESR2, CTNNB1, HSP90AA1
12
Hide members
9.4CDH1, CTNNB1, CTNNA1
139.4CDH1, CTNNB1, CTNNA1
149.4CDH1, CTNNB1, CTNNA1
159.4CTNNA1, CTNNB1, CDH1
16
Hide members
9.4CTNNA1, CTNNB1, CDH1
179.3CTNNB1, CTNND1, CTNNA1
189.3CTNNA1, CTNND1, CTNNB1
19
Cell adhesion Endothelial cell contacts by non-junctional mechanisms
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9.3CTNNB1, CTNND1, CTNNA1
209.1CTNNB1, FGFR1, ESR1, ESR2
21
Hide members
9.0CDH1, CTNNB1, CTNND1, CTNNA1
229.0CDH1, CTNNB1, CTNND1, CTNNA1
239.0CTNNA1, CTNND1, CTNNB1, CDH1
249.0CTNNA1, CTNND1, CTNNB1, CDH1
259.0CTNNA1, CTNND1, CTNNB1, CDH1
269.0CTNNA1, CTNND1, CTNNB1, CDH1
27
Hide members
9.0CTNNA1, CTNND1, CTNNB1, CDH1
28
Development Endothelin-1/EDNRA signaling
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9.0ESR2, ESR1, CTNNB1, HSP90AA1
299.0CTNNA1, CTNND1, CTNNB1, FGFR1
30
Hide members
9.0FGFR1, CTNNB1, CTNNA1, HSP90AA1
31
Hide members
9.0CTNNA1, CTNNB1, CDH1, ESR1
32
Hide members
9.0HSP90AA1, PPP3R1, FGFR1, ESR1
338.8CTNNA1, CTNNB1, PPP3R1, CDH1
34
Hide members
8.8CTNNA1, CTNNB1, PPP3R1, CDH1
35
Hide members
8.8CTNNA1, CTNND1, CTNNB1, CDH1, FGFR1
368.8HSP90AA1, CTNNA1, CTNNB1, CDH1, FGFR1
378.7CTNNA1, CTNND1, CTNNB1, MUC1, CDH1
38
Hide members
8.4HSP90AA1, CTNNB1, PPP3R1, PRLR, CDH1, FGFR1
39
Hide members
8.0HSP90AA1, CTNNB1, PPP3R1, PRLR, CDH1, FGFR1
40
Hide members
7.9CTNNA1, CTNND1, CTNNB1, MUC1, CDH1, FGFR1

Compounds for genes affiliated with Lobular Neoplasia

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1butyrate4410.6PRLR
2butylparaben4410.2ESR2, ESR1
3lasofoxifene4410.2ESR1, ESR2
4ly 1170184410.2ESR1, ESR2
5isobutylparaben4410.2ESR1, ESR2
617alpha estradiol4410.2ESR2, ESR1
72,4,6-trichloro-4-biphenylol4410.2ESR1, ESR2
84-octylphenol4410.2ESR2, ESR1
9(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL1110.2ESR2, ESR1
10(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL1110.1ESR1, ESR2
11(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL1110.1ESR1, ESR2
12r,r-thc2810.1ESR2, ESR1
1317beta-estradiol2810.1ESR1, ESR2
144-hydroxy? tamoxifen2810.1ESR1, ESR2
15methylparaben4410.1ESR1, ESR2
16isopropylparaben4410.1ESR1, ESR2
17serine4410.0ESR2, CDH1, CTNND1
18dihydrotestosterone44 28 11 2412.9HSP90AA1, ESR1, ESR2
19paclitaxel44 49 1111.9ESR1, CDH1, CTNNB1
20[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE119.8ESR2, ESR1
21steroid449.8HSP90AA1, PRLR, ESR1
22dexamethasone44 49 28 1112.6CTNNB1, PRLR, CDH1
23gefitinib44 49 1111.6CTNNB1, CDH1, ESR1, ESR2
24zeranol449.5ESR1, ESR2
255fluorouracil449.5CTNNB1, HSP90AA1, CDH1, MUC1
26nocodazole44 1110.5CTNNB1, CDH1, HSP90AA1, CTNND1
27crcs449.5MUC1, CDH1, CTNNB1
284-hydroxytamoxifen449.5ESR2, HSP90AA1, CTNNB1, ESR1
29geldanamycin44 49 59 1112.5ESR1, CDH1, CTNNB1, HSP90AA1
30progestin449.5CDH1, MUC1, ESR2, ESR1, PRLR
31trastuzumab44 49 1111.4HSP90AA1, CTNNB1, MUC1, ESR1
3212-o-tetradecanoylphorbol 13-acetate449.4CDH1, PRLR, MUC1, FGFR1, CTNNA1
33bicalutamide44 59 1111.3ESR2, CTNNB1, ESR1
34gnrh449.3ESR2, ESR1, FGFR1, PRLR, CTNNB1
35vitamin d449.2ESR1, ESR2, HSP90AA1, CTNNB1, CDH1
36mifepristone44 59 28 1112.2HSP90AA1, MUC1, CTNNB1, ESR2, ESR1
375-aza-2deoxycytidine449.2ESR1, ESR2, CDH1, CTNNB1, CTNNA1
38ly294002449.2HSP90AA1, ESR1, FGFR1, CDH1, CTNNB1
39mg 13244 5910.1CTNNB1, ESR1, CDH1, HSP90AA1
40doxorubicin44 49 1111.0CDH1, ESR2, ESR1, HSP90AA1, CTNNB1
41phosphotyrosine448.9FGFR1, CDH1, CTNNB1, PRLR, CTNND1, CTNNA1
42cysteine448.7ESR2, FGFR1, CDH1, PRLR, CTNNB1, HSP90AA1
43genistein44 28 59 2 11 2413.7ESR1, CDH1, PRLR, ESR2, CTNNB1, HSP90AA1
44tamoxifen44 49 28 1111.7PRLR, MUC1, CDH1, ESR2, HSP90AA1, CTNNB1
45retinoic acid44 249.6FGFR1, MUC1, ESR1, CTNNB1, CDH1, HSP90AA1
46paraffin448.6MUC1, CTNNA1, CDH1, ESR1, ESR2, PRLR
47progesterone44 59 28 11 2412.4ESR1, ESR2, HSP90AA1, CDH1, CTNNB1, PRLR
48testosterone44 59 11 2411.4CDH1, ESR2, ESR1, FGFR1, MUC1, PRLR
49tyrosine448.0HSP90AA1, CTNNA1, CTNND1, CTNNB1, CDH1, PRLR
50vegf448.0FGFR1, HSP90AA1, CTNNA1, CTNND1, CTNNB1, MUC1

GO Terms for genes affiliated with Lobular Neoplasia

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16Gene Ontology
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Cellular components related to Lobular Neoplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1zonula adherensGO:0059159.7CTNNB1, CTNNA1
2cell-cell adherens junctionGO:0059139.6CDH1, CTNNB1, CTNND1
3catenin complexGO:0163429.5CDH1, CTNNB1, CTNNA1
4basolateral plasma membraneGO:0163239.4CDH1, CTNNB1, HSP90AA1
5cell-cell junctionGO:0059119.3CTNNA1, CTNND1, CTNNB1
6cell surfaceGO:0099869.2CDH1, MUC1, PRLR, HSP90AA1
7lamellipodiumGO:0300279.0CTNNA1, CTNND1, CTNNB1

Biological processes related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:01086310.0ESR1, FGFR1
2regulation of protein localization to cell surfaceGO:200000810.0CDH1, CTNNB1
3uterus developmentGO:0600659.9ESR2, ESR1
4intracellular estrogen receptor signaling pathwayGO:0305209.8ESR2, ESR1
5adherens junction organizationGO:0343329.7CTNNA1, CTNND1, CDH1
6cell-cell junction organizationGO:0452169.7CTNNA1, CTNND1, CDH1
7lung-associated mesenchyme developmentGO:0604849.7FGFR1, CTNNB1
8cellular response to indole-3-methanolGO:0716819.6CDH1, CTNNB1, CTNNA1
9cell junction assemblyGO:0343299.6CDH1, CTNND1, CTNNA1
10response to estrogen stimulusGO:0436279.6ESR1, CTNNA1, HSP90AA1
11vagina developmentGO:0600689.5ESR2, ESR1
12cell-cell adhesionGO:0163379.5CTNND1, CTNNB1, CDH1
13neuron migrationGO:0017649.4ESR2, FGFR1, CTNNB1, HSP90AA1

Molecular functions related to Lobular Neoplasia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:03405610.0ESR2, ESR1
2estrogen receptor activityGO:0302849.9ESR1, ESR2
3gamma-catenin bindingGO:0452959.8CDH1, CTNNA1
4nitric-oxide synthase regulator activityGO:0302359.7HSP90AA1, ESR1
5core promoter sequence-specific DNA bindingGO:0010469.5ESR2, ESR1
6cadherin bindingGO:0452969.5CTNNA1, CTNND1, CTNNB1
7beta-catenin bindingGO:0080139.5ESR1, CDH1, CTNNA1
8protein phosphatase bindingGO:0199039.3CDH1, CTNNB1, CTNND1, HSP90AA1
9protein bindingGO:0055156.0HSP90AA1, CTNNA1, CTNND1, CTNNB1, PPP3R1, PRLR

Products for genes affiliated with Lobular Neoplasia

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  • Antibodies
  • Proteins
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Sources for Lobular Neoplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet