MCID: LCL004
MIFTS: 29

Localized Osteosarcoma malady

Bone diseases, Cancer diseases categories

Summaries for Localized Osteosarcoma

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MalaCards based summary: Localized Osteosarcoma, also known as sarcoma, localized osteogenic, is related to sarcoma and multiple myeloma. An important gene associated with Localized Osteosarcoma is FLAD1 (flavin adenine dinucleotide synthetase 1), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The compounds acnu and amifostine have been mentioned in the context of this disorder.

Aliases & Classifications for Localized Osteosarcoma

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Localized Osteosarcoma, Aliases & Descriptions:

Name: Localized Osteosarcoma 10 12 62
Sarcoma, Localized Osteogenic 62
 
Localized Osteogenic Sarcoma 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


External Ids:

Disease Ontology10 DOID:3356
NCIt40 C7780

Related Diseases for Localized Osteosarcoma

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Diseases related to Localized Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1sarcoma10.0
2multiple myeloma10.0TP53, CSF3
3small cell cancer of the lung, somatic10.0TP53, CSF3
4lung cancer10.0TP53, CSF3
5ovarian cancer, somatic10.0TP53, CSF3
6burkitt lymphoma10.0CSF3, TP53

Graphical network of diseases related to Localized Osteosarcoma:



Diseases related to localized osteosarcoma

Symptoms for Localized Osteosarcoma

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Drugs & Therapeutics for Localized Osteosarcoma

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Drug clinical trials:

Search ClinicalTrials for Localized Osteosarcoma

Search NIH Clinical Center for Localized Osteosarcoma

Genetic Tests for Localized Osteosarcoma

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Anatomical Context for Localized Osteosarcoma

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Animal Models for Localized Osteosarcoma or affiliated genes

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Publications for Localized Osteosarcoma

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Articles related to Localized Osteosarcoma:

(show all 23)
idTitleAuthorsYear
1
Prognostic value of pathologic fracture in patients with high grade localized osteosarcoma: A systemic review and meta-analysis of cohort studies. (25231396)
2014
2
Reply to the Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. (25099264)
2014
3
Characterization of localized osteosarcoma of the extremity in children, adolescents, and young adults from a single institution in South Texas. (24487915)
2014
4
Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. (25106799)
2014
5
Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study. (24178953)
2013
6
Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. (22972657)
2013
7
Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. (23226744)
2012
8
Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. (21563300)
2011
9
Frontline treatment of localized osteosarcoma without methotrexate: results of the St. Jude Children's Research Hospital OS99 trial. (21656756)
2011
10
Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group. (21480474)
2011
11
Pharmacokinetic individualization of high-dose methotrexate chemotherapy for the treatment of localized osteosarcoma. (20566424)
2010
12
How can survival be improved in localized osteosarcoma? (20735316)
2010
13
Intensive induction chemotherapy without methotrexate in adult patients with localized osteosarcoma: results of the Institut Gustave-Roussy phase II trial. (21151406)
2010
14
Prognostic effect of pathologic fracture in localized osteosarcoma: a cohort/case controlled study at a single institute. (19294672)
2009
15
Risk stratification based on the clinical factors at diagnosis is closely related to the survival of localized osteosarcoma. (19021220)
2009
16
Tumor necrosis rate adjusted by tumor volume change is a better predictor of survival of localized osteosarcoma patients. (18163171)
2008
17
Initial tumor size predicts histologic response and survival in localized osteosarcoma patients. (18270971)
2008
18
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. (16246977)
2005
19
The feasibility of neoadjuvant high-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with nonmetastatic high grade localized osteosarcoma: results of a phase II study. (15999369)
2005
20
Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. (11516856)
2001
21
Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. (11596036)
2001
22
Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity. (11064353)
2000
23
The treatment of localized osteosarcoma of the extremities: the Italian experience. Studies of the National Research Council. (1622856)
1992

Variations for Localized Osteosarcoma

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Expression for genes affiliated with Localized Osteosarcoma

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Search GEO for disease gene expression data for Localized Osteosarcoma.

Pathways for genes affiliated with Localized Osteosarcoma

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Compounds for genes affiliated with Localized Osteosarcoma

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Compounds related to Localized Osteosarcoma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1acnu459.5CSF3, TP53
2amifostine45 1310.5TP53, CSF3
3taxane459.5CSF3, TP53
4bcnu459.5CSF3, TP53
52-chlorodeoxyadenosine459.5TP53, CSF3
6topotecan45 1310.5CSF3, TP53
7fludarabine45 51 1311.5TP53, CSF3
8melphalan45 51 1311.5CSF3, TP53
9vinblastine45 51 1311.5TP53, CSF3
10bleomycin45 1310.5CSF3, TP53
11irinotecan45 51 1311.4TP53, CSF3
12carboplatin45 51 1311.4TP53, CSF3
13hydroxyurea45 51 1311.4CSF3, TP53
14gemcitabine45 51 1311.4TP53, CSF3
15mitomycin c459.4TP53, CSF3
16vincristine45 51 1311.4TP53, CSF3
17cytarabine45 51 1311.4TP53, CSF3
18adriamycin459.4TP53, CSF3
19docetaxel45 51 61 1312.3TP53, CSF3
20cyclophosphamide45 51 1311.3TP53, CSF3
215fluorouracil459.3TP53, CSF3
22etoposide45 51 61 1312.2TP53, CSF3
23paclitaxel45 51 1311.2TP53, CSF3
24doxorubicin45 51 1311.1TP53, CSF3
25cycloheximide459.1CSF3, TP53
26thymidine45 2610.0TP53, CSF3
27cisplatin45 51 61 1311.8TP53, CSF3

GO Terms for genes affiliated with Localized Osteosarcoma

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Cellular components related to Localized Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial matrixGO:00057599.0FLAD1, TP53

Biological processes related to Localized Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:00459449.1CSF3, TP53
2positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.0CSF3, TP53
3multicellular organismal developmentGO:00072758.8CSF3, TP53

Molecular functions related to Localized Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.1CSF3, TP53

Products for genes affiliated with Localized Osteosarcoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Localized Osteosarcoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet