MCID: LCL004
MIFTS: 19

Localized Osteosarcoma malady

Bone, Cancer categories

Summaries for Localized Osteosarcoma

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33MalaCards
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MalaCards: Localized Osteosarcoma, also known as localized osteogenic sarcoma, is related to laryngeal squamous cell carcinoma and gallbladder cancer. An important gene associated with Localized Osteosarcoma is CYP4V2 (cytochrome P450, family 4, subfamily V, polypeptide 2). The compounds acnu and amifostine have been mentioned in the context of this disorder.

Aliases & Classifications for Localized Osteosarcoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Bone


Aliases & Descriptions:

localized osteosarcoma 8 10 61
localized osteogenic sarcoma 8


External Ids:

Disease Ontology8 DOID:3356
NCIt40 C7780

Related Diseases for Localized Osteosarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases in the osteosarcoma family:

localized osteosarcoma

Diseases related to Localized Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1laryngeal squamous cell carcinoma10.0TP53
2gallbladder cancer10.0TP53
3liposarcoma10.0TP53
4osteosarcoma10.0TP53, CYP4V2

Clinical Features for Localized Osteosarcoma

Drugs & Therapeutics for Localized Osteosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Localized Osteosarcoma

Drug clinical trials:

Search ClinicalTrials for Localized Osteosarcoma

Search NIH Clinical Center for Localized Osteosarcoma

Search CenterWatch for Localized Osteosarcoma

Genetic Tests for Localized Osteosarcoma

Anatomical Context for Localized Osteosarcoma

Animal Models for Localized Osteosarcoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Localized Osteosarcoma

Sources:
51PubMed
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Articles related to Localized Osteosarcoma:

(show all 21)
idTitleAuthorsYear
1
Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study. (24178953)
2013
2
Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. (22972657)
2013
3
Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. (23226744)
2012
4
Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. (21563300)
2011
5
Frontline treatment of localized osteosarcoma without methotrexate: results of the St. Jude Children's Research Hospital OS99 trial. (21656756)
2011
6
RANKL expression is related to treatment outcome of patients with localized, high-grade osteosarcoma. (21370405)
2011
7
Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group. (21480474)
2011
8
Pharmacokinetic individualization of high-dose methotrexate chemotherapy for the treatment of localized osteosarcoma. (20566424)
2010
9
How can survival be improved in localized osteosarcoma? (20735316)
2010
10
Intensive induction chemotherapy without methotrexate in adult patients with localized osteosarcoma: results of the Institut Gustave-Roussy phase II trial. (21151406)
2010
11
Prognostic effect of pathologic fracture in localized osteosarcoma: a cohort/case controlled study at a single institute. (19294672)
2009
12
Risk stratification based on the clinical factors at diagnosis is closely related to the survival of localized osteosarcoma. (19021220)
2009
13
Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein. (18068114)
2008
14
Tumor necrosis rate adjusted by tumor volume change is a better predictor of survival of localized osteosarcoma patients. (18163171)
2008
15
Initial tumor size predicts histologic response and survival in localized osteosarcoma patients. (18270971)
2008
16
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. (16246977)
2005
17
The feasibility of neoadjuvant high-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with nonmetastatic high grade localized osteosarcoma: results of a phase II study. (15999369)
2005
18
Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. (11516856)
2001
19
Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. (11596036)
2001
20
Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity. (11064353)
2000
21
The treatment of localized osteosarcoma of the extremities: the Italian experience. Studies of the National Research Council. (1622856)
1992

Genetic Variations for Localized Osteosarcoma

Expression for genes affiliated with Localized Osteosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Localized Osteosarcoma

Search GEO for disease gene expression data for Localized Osteosarcoma.

Pathways for genes affiliated with Localized Osteosarcoma

Compounds for genes affiliated with Localized Osteosarcoma

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Localized Osteosarcoma according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1acnu459.7TP53, CSF3
2amifostine45 1110.7CSF3, TP53
3taxane459.7CSF3, TP53
4bcnu459.6CSF3, TP53
52-chlorodeoxyadenosine459.6CSF3, TP53
6topotecan45 1110.6CSF3, TP53
7fludarabine45 1110.6CSF3, TP53
8melphalan45 1110.6CSF3, TP53
9vinblastine45 50 1111.6TP53, CSF3
10irinotecan45 50 1111.6CSF3, TP53
11carboplatin45 50 1111.6TP53, CSF3
12bleomycin45 1110.5CSF3, TP53
13gemcitabine45 50 1111.5CSF3, TP53
14hydroxyurea45 50 1111.5CSF3, TP53
15mitomycin c459.4CSF3, TP53
16cytarabine45 50 1111.4CSF3, TP53
17vincristine45 50 1111.3TP53, CSF3
18cyclophosphamide45 50 1111.3TP53, CSF3
19adriamycin459.2TP53, CSF3
20docetaxel45 50 60 1112.0TP53, CSF3

GO Terms for genes affiliated with Localized Osteosarcoma

Sources:
16Gene Ontology
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Biological processes related to Localized Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.3TP53, CSF3

Products for genes affiliated with Localized Osteosarcoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Localized Osteosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet