MCID: LCL004
MIFTS: 28

Localized Osteosarcoma

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Localized Osteosarcoma

MalaCards integrated aliases for Localized Osteosarcoma:

Name: Localized Osteosarcoma 12 14 69
Localized Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3356
NCIt 46 C7780
UMLS 69 C0278511

Summaries for Localized Osteosarcoma

MalaCards based summary : Localized Osteosarcoma, also known as localized osteogenic sarcoma, is related to blastic plasmacytoid dendritic cell and integumentary system cancer. An important gene associated with Localized Osteosarcoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A). The drugs Cisplatin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and liver.

Related Diseases for Localized Osteosarcoma

Diseases related to Localized Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 blastic plasmacytoid dendritic cell 9.8 CDKN2A CLEC4C
2 integumentary system cancer 9.8 CDKN2A GLI2
3 basal cell carcinoma 9.6 CDKN2A GLI2
4 blood group, i system 9.6
5 body mass index quantitative trait locus 1 9.6
6 sarcoma 9.6

Graphical network of the top 20 diseases related to Localized Osteosarcoma:



Diseases related to Localized Osteosarcoma

Symptoms & Phenotypes for Localized Osteosarcoma

Drugs & Therapeutics for Localized Osteosarcoma

Drugs for Localized Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
2
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
3
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
4
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
5
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
6
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
7
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
9
Peginterferon alfa-2b Approved Phase 3 215647-85-1, 99210-65-8
10
Zoledronic acid Approved Phase 3 118072-93-8 68740
11
Cyproheptadine Approved Phase 3 129-03-3 2913
12
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
14
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 143 6006
15
Doxil Approved June 1999 Phase 3,Phase 2 31703
16 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
17 Anti-Bacterial Agents Phase 3,Phase 2
18 Alkylating Agents Phase 3,Phase 2,Phase 1
19 Antirheumatic Agents Phase 3,Phase 2,Phase 1
20 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
21 Anti-Infective Agents Phase 3,Phase 2
22 Liver Extracts Phase 3,Phase 1
23 Antiviral Agents Phase 3,Phase 2
24 Interferon-alpha Phase 3,Phase 2
25 interferons Phase 3,Phase 2
26 Adjuvants, Immunologic Phase 3,Phase 2
27 Antibiotics, Antitubercular Phase 3,Phase 2
28 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
29 Antimetabolites Phase 3,Phase 2
30 Antimetabolites, Antineoplastic Phase 3,Phase 2
31 Antimitotic Agents Phase 3,Phase 2
32 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
33 Dermatologic Agents Phase 3,Phase 2
34 Etoposide phosphate Phase 3,Phase 2,Phase 1
35 Folic Acid Antagonists Phase 3,Phase 2
36 Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
37 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
38 Protective Agents Phase 3,Phase 2
39 razoxane Phase 3,Phase 2
40 Vitamin B Complex Phase 3,Phase 2
41 Antidotes Phase 3,Phase 2
42 Antioxidants Phase 3
43 Antitubercular Agents Phase 3
44 Chelating Agents Phase 3
45 sodium thiosulfate Phase 3
46 Adjuvants, Anesthesia Phase 3
47 Analgesics Phase 3,Phase 2
48 Analgesics, Opioid Phase 3
49 Anesthetics Phase 3
50 Anesthetics, General Phase 3

Interventional clinical trials:

(show all 29)

# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy and Surgery With or Without G-CSF in Treating Patients With Osteosarcoma Completed NCT00002539 Phase 3 cisplatin;doxorubicin hydrochloride
2 Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma Completed NCT00003937 Phase 3 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate
3 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
4 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
5 Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Active, not recruiting NCT00134030 Phase 3 doxorubicin hydrochloride;cisplatin;methotrexate;ifosfamide;etoposide
6 Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma Terminated NCT00470223 Phase 3 cisplatin;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate;zoledronic acid
7 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
8 Interferon Alfa and Thalidomide in Treating Patients With Soft Tissue Sarcoma or Bone Sarcoma Unknown status NCT00026416 Phase 2 thalidomide
9 Samarium Sm 153 and Stem Cell Transplant Followed By Radiation Therapy Patients With Osteosarcoma Completed NCT00245011 Phase 2 ifosfamide
10 Combination Chemotherapy and Radiation Therapy in Treating Patients With Peripheral Neuroectodermal Tumors, Ewing's Sarcoma, Wilms' Tumor, or Bone Cancer Completed NCT00002466 Phase 2 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
11 A Placebo-Controlled Study of Saracatinib (AZD0530) in Patients With Recurrent Osteosarcoma Localized to the Lung Active, not recruiting NCT00752206 Phase 2 Saracatinib;Placebo
12 Sorafenib and Ifosfamide in Treating Patients With High-Grade Soft Tissue Sarcoma or Bone Sarcoma That Can Be Removed by Surgery Terminated NCT00880542 Phase 2 sorafenib;Ifosfamide
13 Combination Chemotherapy Before and After Surgery in Treating Patients With Osteosarcoma Terminated NCT00019864 Phase 2 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;methotrexate
14 Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor Completed NCT00161187 Phase 1
15 High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Cancer Completed NCT00002854 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;mesna;paclitaxel
16 Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer Unknown status NCT00499733 cyclophosphamide
17 Combination Chemotherapy in Treating Patients Undergoing Surgery for Newly Diagnosed High-Grade Osteosarcoma Completed NCT00645632 cisplatin;doxorubicin hydrochloride;ifosfamide;methotrexate
18 Studying DNA in Tumor Tissue Samples From Patients With Localized or Metastatic Osteosarcoma Completed NCT01062438
19 Biomarker Expression in Tissue Samples From Patients With Bone Sarcomas Completed NCT01807052
20 Study of Blood Samples From Patients With Osteosarcoma Completed NCT00954473
21 Biomarkers in Predicting Response to Chemotherapy in Samples From Young Patients With Osteosarcoma Completed NCT01374672
22 Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer Completed NCT00002485
23 Electroacupuncture in Treating Delayed Nausea and Vomiting in Patients Receiving Chemotherapy For Newly Diagnosed Childhood Sarcoma, Neuroblastoma, Nasopharyngeal Cancer, Germ Cell Tumors, or Hodgkin Lymphoma Completed NCT00040911
24 PET Scan Combined With CT Scan in Evaluating Treatment Response in Patients Undergoing Treatment for Bone Cancer or Soft Tissue Sarcoma Completed NCT00335751
25 Genetic Study of Children With Soft Tissue Sarcoma or Rhabdomyosarcoma Completed NCT00003793
26 Collecting and Storing Tissue From Young Patients With Cancer Recruiting NCT00898755
27 DNA Biomarkers in Tissue Samples From Patients With Osteosarcoma Active, not recruiting NCT01190943
28 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 glutamine
29 Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection Withdrawn NCT00378781 Heparin;Minocycline-EDTA

Search NIH Clinical Center for Localized Osteosarcoma

Genetic Tests for Localized Osteosarcoma

Anatomical Context for Localized Osteosarcoma

MalaCards organs/tissues related to Localized Osteosarcoma:

38
Bone, Lung, Liver

Publications for Localized Osteosarcoma

Articles related to Localized Osteosarcoma:

(show all 27)
# Title Authors Year
1
Tumoral immune-infiltrate (IF), PD-L1 expression and role of CD8/TIA-1 lymphocytes in localized osteosarcoma patients treated within protocol ISG-OS1. ( 29340095 )
2017
2
P16 expression as a prognostic and predictive marker in high grade localized osteosarcoma of the extremities: An analysis of 357 cases. ( 27544803 )
2016
3
Developing a prognostic model for patients with localized osteosarcoma treated with uniform chemotherapy protocol without high dose methotrexate: A single-center experience of 237 patients. ( 26381138 )
2015
4
Risk-Based Therapy for Localized Osteosarcoma. ( 26501936 )
2015
5
Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. ( 25106799 )
2014
6
Reply to the Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. ( 25099264 )
2014
7
Characterization of localized osteosarcoma of the extremity in children, adolescents, and young adults from a single institution in South Texas. ( 24487915 )
2014
8
Prognostic value of pathologic fracture in patients with high grade localized osteosarcoma: A systemic review and meta-analysis of cohort studies. ( 25231396 )
2014
9
Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. ( 22972657 )
2013
10
Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study. ( 24178953 )
2013
11
Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. ( 23226744 )
2012
12
Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. ( 21563300 )
2011
13
Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group. ( 21480474 )
2011
14
Frontline treatment of localized osteosarcoma without methotrexate: results of the St. Jude Children's Research Hospital OS99 trial. ( 21656756 )
2011
15
How can survival be improved in localized osteosarcoma? ( 20735316 )
2010
16
Intensive induction chemotherapy without methotrexate in adult patients with localized osteosarcoma: results of the Institut Gustave-Roussy phase II trial. ( 21151406 )
2010
17
Pharmacokinetic individualization of high-dose methotrexate chemotherapy for the treatment of localized osteosarcoma. ( 20566424 )
2010
18
Risk stratification based on the clinical factors at diagnosis is closely related to the survival of localized osteosarcoma. ( 19021220 )
2009
19
Prognostic effect of pathologic fracture in localized osteosarcoma: a cohort/case controlled study at a single institute. ( 19294672 )
2009
20
Initial tumor size predicts histologic response and survival in localized osteosarcoma patients. ( 18270971 )
2008
21
Tumor necrosis rate adjusted by tumor volume change is a better predictor of survival of localized osteosarcoma patients. ( 18163171 )
2008
22
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. ( 16246977 )
2005
23
The feasibility of neoadjuvant high-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with nonmetastatic high grade localized osteosarcoma: results of a phase II study. ( 15999369 )
2005
24
Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. ( 11596036 )
2001
25
Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. ( 11516856 )
2001
26
Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity. ( 11064353 )
2000
27
The treatment of localized osteosarcoma of the extremities: the Italian experience. Studies of the National Research Council. ( 1622856 )
1992

Variations for Localized Osteosarcoma

Expression for Localized Osteosarcoma

Search GEO for disease gene expression data for Localized Osteosarcoma.

Pathways for Localized Osteosarcoma

GO Terms for Localized Osteosarcoma

Biological processes related to Localized Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.16 FRZB GLI2
2 negative regulation of cell growth GO:0030308 8.96 CDKN2A FRZB
3 cochlea morphogenesis GO:0090103 8.62 FRZB GLI2

Sources for Localized Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....