MCID: LCL004
MIFTS: 24

Localized Osteosarcoma malady

Bone diseases, Cancer diseases categories

Aliases & Classifications for Localized Osteosarcoma

About this section

Localized Osteosarcoma, Aliases & Descriptions:

Name: Localized Osteosarcoma 9 11 60
 
Localized Osteogenic Sarcoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


External Ids:

Disease Ontology9 DOID:3356
NCIt38 C7780

Summaries for Localized Osteosarcoma

About this section


MalaCards based summary: Localized Osteosarcoma, also known as localized osteogenic sarcoma, is related to sarcoma and multiple myeloma. An important gene associated with Localized Osteosarcoma is FLAD1 (flavin adenine dinucleotide synthetase 1), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The compounds acnu and amifostine have been mentioned in the context of this disorder.

Related Diseases for Localized Osteosarcoma

About this section

Diseases related to Localized Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1sarcoma10.0
2multiple myeloma9.9CSF3, TP53
3small cell cancer of the lung, somatic9.9CSF3, TP53
4lung cancer9.9CSF3, TP53
5ovarian cancer, somatic9.8CSF3, TP53
6burkitt lymphoma9.7CSF3, TP53

Graphical network of diseases related to Localized Osteosarcoma:



Diseases related to localized osteosarcoma

Symptoms for Localized Osteosarcoma

About this section

Drugs & Therapeutics for Localized Osteosarcoma

About this section

Drug clinical trials:

Search ClinicalTrials for Localized Osteosarcoma

Search NIH Clinical Center for Localized Osteosarcoma

Genetic Tests for Localized Osteosarcoma

About this section

Anatomical Context for Localized Osteosarcoma

About this section

Animal Models for Localized Osteosarcoma or affiliated genes

About this section

Publications for Localized Osteosarcoma

About this section

Articles related to Localized Osteosarcoma:

(show all 23)
idTitleAuthorsYear
1
Prognostic value of pathologic fracture in patients with high grade localized osteosarcoma: A systemic review and meta-analysis of cohort studies. (25231396)
2014
2
Reply to the Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. (25099264)
2014
3
Characterization of localized osteosarcoma of the extremity in children, adolescents, and young adults from a single institution in South Texas. (24487915)
2014
4
Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. (25106799)
2014
5
Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study. (24178953)
2013
6
Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. (22972657)
2013
7
Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. (23226744)
2012
8
Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. (21563300)
2011
9
Frontline treatment of localized osteosarcoma without methotrexate: results of the St. Jude Children's Research Hospital OS99 trial. (21656756)
2011
10
Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group. (21480474)
2011
11
Pharmacokinetic individualization of high-dose methotrexate chemotherapy for the treatment of localized osteosarcoma. (20566424)
2010
12
How can survival be improved in localized osteosarcoma? (20735316)
2010
13
Intensive induction chemotherapy without methotrexate in adult patients with localized osteosarcoma: results of the Institut Gustave-Roussy phase II trial. (21151406)
2010
14
Prognostic effect of pathologic fracture in localized osteosarcoma: a cohort/case controlled study at a single institute. (19294672)
2009
15
Risk stratification based on the clinical factors at diagnosis is closely related to the survival of localized osteosarcoma. (19021220)
2009
16
Tumor necrosis rate adjusted by tumor volume change is a better predictor of survival of localized osteosarcoma patients. (18163171)
2008
17
Initial tumor size predicts histologic response and survival in localized osteosarcoma patients. (18270971)
2008
18
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. (16246977)
2005
19
The feasibility of neoadjuvant high-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with nonmetastatic high grade localized osteosarcoma: results of a phase II study. (15999369)
2005
20
Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. (11516856)
2001
21
Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. (11596036)
2001
22
Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity. (11064353)
2000
23
The treatment of localized osteosarcoma of the extremities: the Italian experience. Studies of the National Research Council. (1622856)
1992

Variations for Localized Osteosarcoma

About this section

Expression for genes affiliated with Localized Osteosarcoma

About this section
Search GEO for disease gene expression data for Localized Osteosarcoma.

Pathways for genes affiliated with Localized Osteosarcoma

About this section

Compounds for genes affiliated with Localized Osteosarcoma

About this section

Compounds related to Localized Osteosarcoma according to GeneCards Suite gene sharing:

(show all 27)
idCompoundScoreTop Affiliating Genes
1acnu439.5CSF3, TP53
2amifostine43 1210.5CSF3, TP53
3taxane439.5CSF3, TP53
4bcnu439.5TP53, CSF3
52-chlorodeoxyadenosine439.5CSF3, TP53
6topotecan43 1210.5CSF3, TP53
7fludarabine43 49 1211.5TP53, CSF3
8melphalan43 49 1211.5CSF3, TP53
9vinblastine43 49 1211.5CSF3, TP53
10bleomycin43 1210.5CSF3, TP53
11irinotecan43 49 1211.4TP53, CSF3
12carboplatin43 49 1211.4CSF3, TP53
13hydroxyurea43 49 1211.4CSF3, TP53
14gemcitabine43 49 1211.4TP53, CSF3
15mitomycin c439.4CSF3, TP53
16vincristine43 49 1211.4CSF3, TP53
17cytarabine43 49 1211.4CSF3, TP53
18adriamycin439.4TP53, CSF3
19docetaxel43 49 59 1212.3CSF3, TP53
20cyclophosphamide43 49 1211.3CSF3, TP53
215fluorouracil439.3TP53, CSF3
22etoposide43 49 59 1212.2CSF3, TP53
23paclitaxel43 49 1211.2CSF3, TP53
24doxorubicin43 49 1211.1TP53, CSF3
25cycloheximide439.1CSF3, TP53
26thymidine43 2410.0CSF3, TP53
27cisplatin43 49 59 1211.8CSF3, TP53

GO Terms for genes affiliated with Localized Osteosarcoma

About this section

Cellular components related to Localized Osteosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial matrixGO:00057599.0FLAD1, TP53

Biological processes related to Localized Osteosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:00459449.1CSF3, TP53
2positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.0CSF3, TP53
3multicellular organismal developmentGO:00072758.8CSF3, TP53

Molecular functions related to Localized Osteosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.1CSF3, TP53

Products for genes affiliated with Localized Osteosarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Localized Osteosarcoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet