MCID: LCL004
MIFTS: 32

Localized Osteosarcoma malady

Cancer diseases, Bone diseases, Rare diseases categories
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Summaries for Localized Osteosarcoma

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MalaCards based summary: Localized Osteosarcoma, also known as sarcoma, localized osteogenic, is related to osteosarcoma and sarcoma. An important gene associated with Localized Osteosarcoma is FLAD1 (flavin adenine dinucleotide synthetase 1), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The compounds acnu and amifostine have been mentioned in the context of this disorder.

Aliases & Classifications for Localized Osteosarcoma

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Localized Osteosarcoma, Aliases & Descriptions:

Name: Localized Osteosarcoma 8 10 62
Sarcoma, Localized Osteogenic 62
 
Localized Osteogenic Sarcoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Bone diseases


External Ids:

Disease Ontology8 DOID:3356
NCIt39 C7780

Related Diseases for Localized Osteosarcoma

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Diseases in the Osteosarcoma family:

localized osteosarcoma

Diseases related to Localized Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1osteosarcoma10.7
2sarcoma10.0
3multiple myeloma9.9TP53, CSF3
4lung small cell carcinoma9.9TP53, CSF3
5non-small cell lung carcinoma9.9TP53, CSF3
6lung cancer9.9TP53, CSF3
7ovarian cancer9.8TP53, CSF3
8burkitt's lymphoma9.8CSF3, TP53

Graphical network of diseases related to Localized Osteosarcoma:



Diseases related to localized osteosarcoma

Symptoms for Localized Osteosarcoma

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Drugs & Therapeutics for Localized Osteosarcoma

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Drug clinical trials:

Search ClinicalTrials for Localized Osteosarcoma

Search NIH Clinical Center for Localized Osteosarcoma

Genetic Tests for Localized Osteosarcoma

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Anatomical Context for Localized Osteosarcoma

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Animal Models for Localized Osteosarcoma or affiliated genes

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Publications for Localized Osteosarcoma

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Articles related to Localized Osteosarcoma:

(show all 23)
idTitleAuthorsYear
1
Prognostic value of pathologic fracture in patients with high grade localized osteosarcoma: A systemic review and meta-analysis of cohort studies. (25231396)
2014
2
Reply to the Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. (25099264)
2014
3
Characterization of localized osteosarcoma of the extremity in children, adolescents, and young adults from a single institution in South Texas. (24487915)
2014
4
Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. (25106799)
2014
5
Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study. (24178953)
2013
6
Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. (22972657)
2013
7
Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. (23226744)
2012
8
Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. (21563300)
2011
9
Frontline treatment of localized osteosarcoma without methotrexate: results of the St. Jude Children's Research Hospital OS99 trial. (21656756)
2011
10
Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group. (21480474)
2011
11
Pharmacokinetic individualization of high-dose methotrexate chemotherapy for the treatment of localized osteosarcoma. (20566424)
2010
12
How can survival be improved in localized osteosarcoma? (20735316)
2010
13
Intensive induction chemotherapy without methotrexate in adult patients with localized osteosarcoma: results of the Institut Gustave-Roussy phase II trial. (21151406)
2010
14
Prognostic effect of pathologic fracture in localized osteosarcoma: a cohort/case controlled study at a single institute. (19294672)
2009
15
Risk stratification based on the clinical factors at diagnosis is closely related to the survival of localized osteosarcoma. (19021220)
2009
16
Tumor necrosis rate adjusted by tumor volume change is a better predictor of survival of localized osteosarcoma patients. (18163171)
2008
17
Initial tumor size predicts histologic response and survival in localized osteosarcoma patients. (18270971)
2008
18
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. (16246977)
2005
19
The feasibility of neoadjuvant high-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with nonmetastatic high grade localized osteosarcoma: results of a phase II study. (15999369)
2005
20
Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. (11516856)
2001
21
Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. (11596036)
2001
22
Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity. (11064353)
2000
23
The treatment of localized osteosarcoma of the extremities: the Italian experience. Studies of the National Research Council. (1622856)
1992

Variations for Localized Osteosarcoma

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Expression for genes affiliated with Localized Osteosarcoma

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Expression patterns in normal tissues for genes affiliated with Localized Osteosarcoma

Search GEO for disease gene expression data for Localized Osteosarcoma.

Pathways for genes affiliated with Localized Osteosarcoma

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Compounds for genes affiliated with Localized Osteosarcoma

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Compounds related to Localized Osteosarcoma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1acnu449.5CSF3, TP53
2amifostine44 1110.5CSF3, TP53
3taxane449.5CSF3, TP53
4bcnu449.5TP53, CSF3
52-chlorodeoxyadenosine449.5CSF3, TP53
6topotecan44 1110.5CSF3, TP53
7fludarabine44 50 1111.5TP53, CSF3
8melphalan44 50 1111.5CSF3, TP53
9vinblastine44 50 1111.5CSF3, TP53
10bleomycin44 1110.5CSF3, TP53
11irinotecan44 50 1111.4TP53, CSF3
12carboplatin44 50 1111.4CSF3, TP53
13hydroxyurea44 50 1111.4CSF3, TP53
14gemcitabine44 50 1111.4TP53, CSF3
15mitomycin c449.4CSF3, TP53
16vincristine44 50 1111.4CSF3, TP53
17cytarabine44 50 1111.4CSF3, TP53
18adriamycin449.4TP53, CSF3
19docetaxel44 50 61 1112.3CSF3, TP53
20cyclophosphamide44 50 1111.3CSF3, TP53
215fluorouracil449.3TP53, CSF3
22etoposide44 50 61 1112.2CSF3, TP53
23paclitaxel44 50 1111.2CSF3, TP53
24doxorubicin44 50 1111.1TP53, CSF3
25cycloheximide449.1CSF3, TP53
26thymidine44 2410.0CSF3, TP53
27cisplatin44 50 61 1111.8CSF3, TP53

GO Terms for genes affiliated with Localized Osteosarcoma

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Cellular components related to Localized Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial matrixGO:0057599.0FLAD1, TP53

Biological processes related to Localized Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:0459449.1CSF3, TP53
2positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.0CSF3, TP53
3multicellular organismal developmentGO:0072758.8CSF3, TP53

Molecular functions related to Localized Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.1CSF3, TP53

Products for genes affiliated with Localized Osteosarcoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Localized Osteosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet