MCID: LCL004
MIFTS: 35

Localized Osteosarcoma malady

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Localized Osteosarcoma

Aliases & Descriptions for Localized Osteosarcoma:

Name: Localized Osteosarcoma 12 14 69
Localized Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3356
NCIt 47 C7780
UMLS 69 C0278511

Summaries for Localized Osteosarcoma

MalaCards based summary : Localized Osteosarcoma, also known as localized osteogenic sarcoma, is related to bacterial vaginosis and heel spur. An important gene associated with Localized Osteosarcoma is CYP4V2 (Cytochrome P450 Family 4 Subfamily V Member 2), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Glucose / Energy Metabolism. The drugs Doxorubicin and Vincristine have been mentioned in the context of this disorder. Related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Localized Osteosarcoma

Graphical network of the top 20 diseases related to Localized Osteosarcoma:



Diseases related to Localized Osteosarcoma

Symptoms & Phenotypes for Localized Osteosarcoma

MGI Mouse Phenotypes related to Localized Osteosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 IL13 RUNX2 SLC13A2 SLC13A5 TP53 TTR
2 growth/size/body region MP:0005378 10.13 CARTPT GHR GLI2 IGF1R IGFBP3 IL13
3 endocrine/exocrine gland MP:0005379 10.06 GLI2 IGF1R IGFBP3 IL13 RUNX2 TP53
4 integument MP:0010771 9.97 CSF3 GHR GLI2 IGF1R IGFBP3 IL13
5 adipose tissue MP:0005375 9.95 CARTPT GHR IGF1R IGFBP3 SLC13A5 TP53
6 muscle MP:0005369 9.81 GHR GLI2 IGF1R IGFBP3 IL13 RUNX2
7 limbs/digits/tail MP:0005371 9.8 GHR GLI2 IGF1R RUNX2 TP53 TWIST1
8 liver/biliary system MP:0005370 9.8 GHR IGF1R IGFBP2 IGFBP3 RUNX2 SLC13A5
9 no phenotypic analysis MP:0003012 9.43 GLI2 IL13 RUNX2 SLC13A5 TP53 TTR
10 skeleton MP:0005390 9.23 CARTPT GHR GLI2 IGF1R IL13 RUNX2

Drugs & Therapeutics for Localized Osteosarcoma

Drugs for Localized Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 139)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
2
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
3
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
4
Melphalan Approved Phase 3,Phase 2 148-82-3 4053 460612
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
6
Busulfan Approved, Investigational Phase 3,Phase 2 55-98-1 2478
7
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
8
Mechlorethamine Approved Phase 3,Phase 2,Phase 1 51-75-2 4033
9
Mesna Approved Phase 3,Phase 1 3375-50-6 598
10
Dactinomycin Approved Phase 3 50-76-0 2019 457193
11
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
12
Topotecan Approved, Investigational Phase 3,Phase 1 119413-54-6, 123948-87-8 60700
13
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
14
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
15 Sodium thiosulfate Approved Phase 3
16
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
17
Zoledronic acid Approved Phase 3 118072-93-8 68740
18
Peginterferon alfa-2b Approved Phase 3 99210-65-8, 215647-85-1
19
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
20
Cyproheptadine Approved Phase 3 129-03-3 2913
21
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 54575, 6560146 143
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
23
Doxil Approved June 1999 Phase 3,Phase 2 31703
24
Cobalt Phase 3 7440-48-4 104729
25 interferons Phase 3,Phase 2
26 Alkylating Agents Phase 3,Phase 2,Phase 1
27 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
28 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
29 Anti-Bacterial Agents Phase 3,Phase 2
30 Etoposide phosphate Phase 3,Phase 2,Phase 1
31 Anti-Infective Agents Phase 3,Phase 2
32 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
33 Interferon-alpha Phase 3,Phase 2
34 Isophosphamide mustard Phase 3,Phase 2,Phase 1
35 Liver Extracts Phase 3,Phase 2,Phase 1
36 Antibiotics, Antitubercular Phase 3,Phase 2
37 Antimitotic Agents Phase 3,Phase 2
38 Antirheumatic Agents Phase 3,Phase 2,Phase 1
39 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
40 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
41 Antiviral Agents Phase 3,Phase 2
42 pancreatic polypeptide Phase 3
43 razoxane Phase 3,Phase 2
44 Analgesics Phase 3,Phase 2
45 topoisomerase I inhibitors Phase 3,Phase 2,Phase 1
46 Chelating Agents Phase 3
47 Adjuvants, Anesthesia Phase 3
48 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
49 Folic Acid Antagonists Phase 3,Phase 2
50 Narcotics Phase 3

Interventional clinical trials:

(show top 50) (show all 57)
id Name Status NCT ID Phase
1 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Unknown status NCT00020566 Phase 3
2 Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma Unknown status NCT00002516 Phase 3
3 Combination Chemotherapy and Surgery With or Without G-CSF in Treating Patients With Osteosarcoma Completed NCT00002539 Phase 3
4 Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma Completed NCT00003937 Phase 3
5 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3
6 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
7 Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children Completed NCT00180908 Phase 3
8 Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor Completed NCT00006734 Phase 3
9 Study in Localized and Disseminated Ewing Sarcoma Recruiting NCT00987636 Phase 3
10 Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Active, not recruiting NCT00134030 Phase 3
11 Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Active, not recruiting NCT01231906 Phase 3
12 Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma Terminated NCT00470223 Phase 3
13 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
14 Combination Chemotherapy With or Without Topotecan in Treating Patients With Newly Diagnosed Localized Ewing's Sarcoma Withdrawn NCT00334867 Phase 3
15 Interferon Alfa and Thalidomide in Treating Patients With Soft Tissue Sarcoma or Bone Sarcoma Unknown status NCT00026416 Phase 2
16 Samarium Sm 153 and Stem Cell Transplant Followed By Radiation Therapy Patients With Osteosarcoma Completed NCT00245011 Phase 2
17 Combination Chemotherapy and Radiation Therapy in Treating Patients With Peripheral Neuroectodermal Tumors, Ewing's Sarcoma, Wilms' Tumor, or Bone Cancer Completed NCT00002466 Phase 2
18 Osteosarcoma1999-A Study Of Intensive Chemotherapy for Osteosarcoma Completed NCT00145639 Phase 2
19 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2
20 Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors Completed NCT00024258 Phase 2
21 Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma Completed NCT00003667 Phase 2
22 Exatecan Mesylate in Treating Patients With Ewing's Sarcoma, Primitive Neuroectodermal Tumor, or Desmoplastic Small Round Cell Tumor Completed NCT00055952 Phase 2
23 Irinotecan and Temozolomide in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Patients With Newly Diagnosed Ewing Sarcoma Recruiting NCT01864109 Phase 2
24 First-line Treatment of Ewing Tumours With Primary Extrapulmonary Dissemination in Patients From 2 to 50 Years Recruiting NCT03011528 Phase 2
25 A Placebo-Controlled Study of Saracatinib (AZD0530) in Patients With Recurrent Osteosarcoma Localized to the Lung Active, not recruiting NCT00752206 Phase 2
26 A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma Active, not recruiting NCT00667342 Phase 2
27 Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors Active, not recruiting NCT01946529 Phase 2
28 Sorafenib and Ifosfamide in Treating Patients With High-Grade Soft Tissue Sarcoma or Bone Sarcoma That Can Be Removed by Surgery Terminated NCT00880542 Phase 2
29 Combination Chemotherapy Before and After Surgery in Treating Patients With Osteosarcoma Terminated NCT00019864 Phase 2
30 Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor Completed NCT00161187 Phase 1
31 High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Cancer Completed NCT00002854 Phase 1
32 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1
33 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1
34 HSV1716 in Patients With Non-Central Nervous System (Non-CNS) Solid Tumors Recruiting NCT00931931 Phase 1
35 Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors Recruiting NCT02390843 Phase 1
36 Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer Unknown status NCT00499733
37 Combination Chemotherapy in Treating Patients Undergoing Surgery for Newly Diagnosed High-Grade Osteosarcoma Completed NCT00645632
38 Studying DNA in Tumor Tissue Samples From Patients With Localized or Metastatic Osteosarcoma Completed NCT01062438
39 Study of Blood Samples From Patients With Osteosarcoma Completed NCT00954473
40 Biomarker Expression in Tissue Samples From Patients With Bone Sarcomas Completed NCT01807052
41 Biomarkers in Predicting Response to Chemotherapy in Samples From Young Patients With Osteosarcoma Completed NCT01374672
42 PET Scan Combined With CT Scan in Evaluating Treatment Response in Patients Undergoing Treatment for Bone Cancer or Soft Tissue Sarcoma Completed NCT00335751
43 Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer Completed NCT00002485
44 Electroacupuncture in Treating Delayed Nausea and Vomiting in Patients Receiving Chemotherapy For Newly Diagnosed Childhood Sarcoma, Neuroblastoma, Nasopharyngeal Cancer, Germ Cell Tumors, or Hodgkin Lymphoma Completed NCT00040911
45 Genetic Study of Children With Soft Tissue Sarcoma or Rhabdomyosarcoma Completed NCT00003793
46 Detection of Circulating Osteosarcoma Tumor Cells in the Blood of Patients Using the Polymerase Chain Reaction Completed NCT00588510
47 Two Regimens of Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed Localized Ewing Sarcoma Family of Tumors Completed NCT00618813
48 Study of Tumor Samples From Patients With Ewing Sarcoma Completed NCT00898053
49 Biomarkers in Tissue Samples From Patients With Ewing Sarcoma Completed NCT01480518
50 Diagnostic Study of Tumor Characteristics in Patients With Ewing's Sarcoma Completed NCT00048984

Search NIH Clinical Center for Localized Osteosarcoma

Genetic Tests for Localized Osteosarcoma

Anatomical Context for Localized Osteosarcoma

Publications for Localized Osteosarcoma

Articles related to Localized Osteosarcoma:

(show all 26)
id Title Authors Year
1
P16 expression as a prognostic and predictive marker in high grade localized osteosarcoma of the extremities: An analysis of 357 cases. ( 27544803 )
2016
2
Developing a prognostic model for patients with localized osteosarcoma treated with uniform chemotherapy protocol without high dose methotrexate: A single-center experience of 237 patients. ( 26381138 )
2015
3
Risk-Based Therapy for Localized Osteosarcoma. ( 26501936 )
2015
4
Reply to the Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. ( 25099264 )
2014
5
Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. ( 25106799 )
2014
6
Prognostic value of pathologic fracture in patients with high grade localized osteosarcoma: A systemic review and meta-analysis of cohort studies. ( 25231396 )
2014
7
Characterization of localized osteosarcoma of the extremity in children, adolescents, and young adults from a single institution in South Texas. ( 24487915 )
2014
8
Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study. ( 24178953 )
2013
9
Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. ( 22972657 )
2013
10
Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. ( 23226744 )
2012
11
Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group. ( 21480474 )
2011
12
Frontline treatment of localized osteosarcoma without methotrexate: results of the St. Jude Children's Research Hospital OS99 trial. ( 21656756 )
2011
13
Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. ( 21563300 )
2011
14
Pharmacokinetic individualization of high-dose methotrexate chemotherapy for the treatment of localized osteosarcoma. ( 20566424 )
2010
15
Intensive induction chemotherapy without methotrexate in adult patients with localized osteosarcoma: results of the Institut Gustave-Roussy phase II trial. ( 21151406 )
2010
16
How can survival be improved in localized osteosarcoma? ( 20735316 )
2010
17
Risk stratification based on the clinical factors at diagnosis is closely related to the survival of localized osteosarcoma. ( 19021220 )
2009
18
Prognostic effect of pathologic fracture in localized osteosarcoma: a cohort/case controlled study at a single institute. ( 19294672 )
2009
19
Tumor necrosis rate adjusted by tumor volume change is a better predictor of survival of localized osteosarcoma patients. ( 18163171 )
2008
20
Initial tumor size predicts histologic response and survival in localized osteosarcoma patients. ( 18270971 )
2008
21
The feasibility of neoadjuvant high-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with nonmetastatic high grade localized osteosarcoma: results of a phase II study. ( 15999369 )
2005
22
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. ( 16246977 )
2005
23
Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. ( 11516856 )
2001
24
Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. ( 11596036 )
2001
25
Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity. ( 11064353 )
2000
26
The treatment of localized osteosarcoma of the extremities: the Italian experience. Studies of the National Research Council. ( 1622856 )
1992

Variations for Localized Osteosarcoma

Expression for Localized Osteosarcoma

Search GEO for disease gene expression data for Localized Osteosarcoma.

Pathways for Localized Osteosarcoma

GO Terms for Localized Osteosarcoma

Cellular components related to Localized Osteosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CARTPT CSF3 GHR IGFBP2 IGFBP3 IL13

Biological processes related to Localized Osteosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.5 CSF3 GHR TP53
2 response to mechanical stimulus GO:0009612 9.43 GLI2 IGFBP2 IL13
3 osteoblast development GO:0002076 9.4 GLI2 RUNX2
4 insulin-like growth factor receptor signaling pathway GO:0048009 9.37 GHR IGF1R
5 regulation of insulin-like growth factor receptor signaling pathway GO:0043567 9.16 IGFBP2 IGFBP3
6 negative regulation of neuron death GO:1901215 9.13 CSF3 GHR IL13
7 osteoblast differentiation GO:0001649 8.92 GLI2 IGFBP3 RUNX2 TWIST1

Molecular functions related to Localized Osteosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 bHLH transcription factor binding GO:0043425 9.26 RUNX2 TWIST1
2 insulin-like growth factor II binding GO:0031995 9.16 IGFBP2 IGFBP3
3 insulin-like growth factor binding GO:0005520 9.13 IGF1R IGFBP2 IGFBP3
4 insulin-like growth factor I binding GO:0031994 8.8 IGF1R IGFBP2 IGFBP3

Sources for Localized Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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