MCID: LCL004
MIFTS: 30

Localized Osteosarcoma malady

Cancer diseases, Bone diseases, Rare diseases categories
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Summaries for Localized Osteosarcoma

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33MalaCards
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MalaCards: Localized Osteosarcoma, also known as localized osteogenic sarcoma, is related to osteosarcoma and sarcoma. An important gene associated with Localized Osteosarcoma is FLAD1 (flavin adenine dinucleotide synthetase 1), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The compounds acnu and amifostine have been mentioned in the context of this disorder.

Aliases & Classifications for Localized Osteosarcoma

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Bone diseases


Aliases & Descriptions:

localized osteosarcoma 8 10 62
localized osteogenic sarcoma 8


External Ids:

Disease Ontology8 DOID:3356
NCIt40 C7780

Related Diseases for Localized Osteosarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Osteosarcoma family:

localized osteosarcoma

Diseases related to Localized Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1osteosarcoma10.7
2sarcoma10.0
3multiple myeloma10.0CSF3, TP53
4lung small cell carcinoma10.0CSF3, TP53
5non-small cell lung carcinoma10.0CSF3, TP53
6lung cancer10.0CSF3, TP53
7ovarian cancer10.0CSF3, TP53
8burkitt's lymphoma9.9CSF3, TP53

Graphical network of diseases related to Localized Osteosarcoma:



Diseases related to localized osteosarcoma

Symptoms for Localized Osteosarcoma

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Drugs & Therapeutics for Localized Osteosarcoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Localized Osteosarcoma

Search NIH Clinical Center for Localized Osteosarcoma

Genetic Tests for Localized Osteosarcoma

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Anatomical Context for Localized Osteosarcoma

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Animal Models for Localized Osteosarcoma or affiliated genes

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Publications for Localized Osteosarcoma

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52PubMed
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Articles related to Localized Osteosarcoma:

(show all 19)
idTitleAuthorsYear
1
Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study. (24178953)
2013
2
Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. (22972657)
2013
3
Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. (23226744)
2012
4
Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. (21563300)
2011
5
Frontline treatment of localized osteosarcoma without methotrexate: results of the St. Jude Children's Research Hospital OS99 trial. (21656756)
2011
6
Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group. (21480474)
2011
7
Pharmacokinetic individualization of high-dose methotrexate chemotherapy for the treatment of localized osteosarcoma. (20566424)
2010
8
How can survival be improved in localized osteosarcoma? (20735316)
2010
9
Intensive induction chemotherapy without methotrexate in adult patients with localized osteosarcoma: results of the Institut Gustave-Roussy phase II trial. (21151406)
2010
10
Prognostic effect of pathologic fracture in localized osteosarcoma: a cohort/case controlled study at a single institute. (19294672)
2009
11
Risk stratification based on the clinical factors at diagnosis is closely related to the survival of localized osteosarcoma. (19021220)
2009
12
Tumor necrosis rate adjusted by tumor volume change is a better predictor of survival of localized osteosarcoma patients. (18163171)
2008
13
Initial tumor size predicts histologic response and survival in localized osteosarcoma patients. (18270971)
2008
14
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. (16246977)
2005
15
The feasibility of neoadjuvant high-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with nonmetastatic high grade localized osteosarcoma: results of a phase II study. (15999369)
2005
16
Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. (11516856)
2001
17
Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. (11596036)
2001
18
Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity. (11064353)
2000
19
The treatment of localized osteosarcoma of the extremities: the Italian experience. Studies of the National Research Council. (1622856)
1992

Variations for Localized Osteosarcoma

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Expression for genes affiliated with Localized Osteosarcoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Localized Osteosarcoma

Search GEO for disease gene expression data for Localized Osteosarcoma.

Pathways for genes affiliated with Localized Osteosarcoma

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Sources:
50PathCards, 53QIAGEN, 30KEGG
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Compounds for genes affiliated with Localized Osteosarcoma

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB
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Compounds related to Localized Osteosarcoma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1acnu459.5CSF3, TP53
2amifostine45 1110.5CSF3, TP53
3taxane459.5CSF3, TP53
4bcnu459.5TP53, CSF3
52-chlorodeoxyadenosine459.5CSF3, TP53
6topotecan45 1110.5CSF3, TP53
7fludarabine45 51 1111.5TP53, CSF3
8melphalan45 51 1111.5CSF3, TP53
9vinblastine45 51 1111.5CSF3, TP53
10bleomycin45 1110.5CSF3, TP53
11irinotecan45 51 1111.4TP53, CSF3
12carboplatin45 51 1111.4CSF3, TP53
13hydroxyurea45 51 1111.4CSF3, TP53
14gemcitabine45 51 1111.4TP53, CSF3
15mitomycin c459.4CSF3, TP53
16vincristine45 51 1111.4CSF3, TP53
17cytarabine45 51 1111.4CSF3, TP53
18adriamycin459.4TP53, CSF3
19docetaxel45 51 61 1112.3CSF3, TP53
20cyclophosphamide45 51 1111.3CSF3, TP53
215fluorouracil459.3TP53, CSF3
22etoposide45 51 61 1112.2CSF3, TP53
23paclitaxel45 51 1111.2CSF3, TP53
24doxorubicin45 51 1111.1TP53, CSF3
25cycloheximide459.1CSF3, TP53
26thymidine45 2410.0CSF3, TP53
27cisplatin45 51 61 1111.8CSF3, TP53

GO Terms for genes affiliated with Localized Osteosarcoma

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16Gene Ontology
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Cellular components related to Localized Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial matrixGO:0057599.0FLAD1, TP53

Biological processes related to Localized Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:0459449.1CSF3, TP53
2positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.0CSF3, TP53
3multicellular organismal developmentGO:0072758.8CSF3, TP53

Molecular functions related to Localized Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.1CSF3, TP53

Products for genes affiliated with Localized Osteosarcoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Localized Osteosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet