MCID: LCL004
MIFTS: 27

Localized Osteosarcoma malady

Bone diseases, Cancer diseases categories

Summaries for Localized Osteosarcoma

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32MalaCards
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MalaCards: Localized Osteosarcoma, also known as localized osteogenic sarcoma, is related to osteosarcoma and peripheral osteosarcoma. An important gene associated with Localized Osteosarcoma is CYP4V2 (cytochrome P450, family 4, subfamily V, polypeptide 2). The compounds acnu and amifostine have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Localized Osteosarcoma

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


Aliases & Descriptions:

localized osteosarcoma 8 10 60
localized osteogenic sarcoma 8


External Ids:

Disease Ontology8 DOID:3356
NCIt39 C7780

Related Diseases for Localized Osteosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Osteosarcoma family:

localized osteosarcoma

Diseases related to Localized Osteosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1osteosarcoma30.9TP53, CYP4V2
2peripheral osteosarcoma10.0
3sarcoma10.0
4laryngeal squamous cell carcinoma10.0TP53
5gallbladder cancer10.0TP53
6liposarcoma10.0TP53

Graphical network of diseases related to Localized Osteosarcoma:



Diseases related to localized osteosarcoma

Clinical Features for Localized Osteosarcoma

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Drugs & Therapeutics for Localized Osteosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Localized Osteosarcoma

Drug clinical trials:

Search ClinicalTrials for Localized Osteosarcoma

Search NIH Clinical Center for Localized Osteosarcoma

Search CenterWatch for Localized Osteosarcoma

Genetic Tests for Localized Osteosarcoma

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Anatomical Context for Localized Osteosarcoma

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32MalaCards
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MalaCards organs/tissues related to Localized Osteosarcoma:

32
Bone

Animal Models for Localized Osteosarcoma or affiliated genes

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Publications for Localized Osteosarcoma

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50PubMed
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Articles related to Localized Osteosarcoma:

(show all 36)
idTitleAuthorsYear
1
Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study. (24178953)
2013
2
Role of surgical margin on local recurrence in high risk extremity osteosarcoma: a case-controlled study. (24009908)
2013
3
Central low-grade osteosarcoma with an unusual localization in the diaphysis of a 12-year old patient. (23801917)
2013
4
Bcl-2 correlates with localization but not outcome in human osteosarcoma. (24137369)
2013
5
Osteosarcoma: A Comparison of Jaw versus Nonjaw Localizations and Review of the Literature. (23956680)
2013
6
Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. (22972657)
2013
7
Phase II study of sequential gemcitabine followed by docetaxel for recurrent Ewing sarcoma, osteosarcoma, or unresectable or locally recurrent chondrosarcoma: results of Sarcoma Alliance for Research Through Collaboration Study 003. (22363068)
2012
8
Expression and localization of ArgBP2 in osteosarcoma MG-63 cells]. (22394629)
2012
9
Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. (23226744)
2012
10
Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. (21563300)
2011
11
Frontline treatment of localized osteosarcoma without methotrexate: results of the St. Jude Children's Research Hospital OS99 trial. (21656756)
2011
12
RANKL expression is related to treatment outcome of patients with localized, high-grade osteosarcoma. (21370405)
2011
13
Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group. (21480474)
2011
14
Pharmacokinetic individualization of high-dose methotrexate chemotherapy for the treatment of localized osteosarcoma. (20566424)
2010
15
How can survival be improved in localized osteosarcoma? (20735316)
2010
16
Intensive induction chemotherapy without methotrexate in adult patients with localized osteosarcoma: results of the Institut Gustave-Roussy phase II trial. (21151406)
2010
17
Prognostic effect of pathologic fracture in localized osteosarcoma: a cohort/case controlled study at a single institute. (19294672)
2009
18
Risk stratification based on the clinical factors at diagnosis is closely related to the survival of localized osteosarcoma. (19021220)
2009
19
Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein. (18068114)
2008
20
Tumor necrosis rate adjusted by tumor volume change is a better predictor of survival of localized osteosarcoma patients. (18163171)
2008
21
Localization of prohibitin in nuclear matrix and its expressive alteration during the differentiation of human osteosarcoma MG-63 cells induced by HMBA]. (18464584)
2008
22
Expression and localization of hnRNP A2/B1 during differentiation of human osteosarcoma MG-63 cells induced by HMBA]. (18606058)
2008
23
Initial tumor size predicts histologic response and survival in localized osteosarcoma patients. (18270971)
2008
24
Differential distribution of glucocorticoid and estrogen receptor isoforms: localization of GRbeta and ERalpha in nucleoli and GRalpha and ERbeta in the mitochondria of human osteosarcoma SaOS-2 and hepatocarcinoma HepG2 cell lines. (17947807)
2007
25
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. (16246977)
2005
26
Differential subcellular distribution of estrogen receptor isoforms: localization of ERalpha in the nucleoli and ERbeta in the mitochondria of human osteosarcoma SaOS-2 and hepatocarcinoma HepG2 cell lines. (15993498)
2005
27
The feasibility of neoadjuvant high-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with nonmetastatic high grade localized osteosarcoma: results of a phase II study. (15999369)
2005
28
Immunofluorescence localization of prolyl 4-hydroxylase isoenzymes and type I and II collagens in bone tumours: type I enzyme predominates in osteosarcomas and chondrosarcomas, whereas type II enzyme predominates in their benign counterparts. (15147632)
2004
29
Local secretion of parathyroid hormone-related protein by an osteoblastic osteosarcoma (UMR 106-01) cell line results in growth inhibition. (12477574)
2002
30
Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. (11516856)
2001
31
Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. (11596036)
2001
32
Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity. (11064353)
2000
33
P-glycoprotein subcellular localization and cell morphotype in MDR1 gene-transfected human osteosarcoma cells. (10321019)
1999
34
Immunohistochemical localization of bone Gla protein and osteonectin in normal human bone and cartilage tissues, and in osteosarcomas and chondrosarcomas]. (8336066)
1993
35
The treatment of localized osteosarcoma of the extremities: the Italian experience. Studies of the National Research Council. (1622856)
1992
36
Problems and pitfalls in the use of computed tomography for the local evaluation of long bone osteosarcoma: report on 30 cases. (3856325)
1985

Genetic Variations for Localized Osteosarcoma

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Expression for genes affiliated with Localized Osteosarcoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Localized Osteosarcoma

Search GEO for disease gene expression data for Localized Osteosarcoma.

Pathways for genes affiliated with Localized Osteosarcoma

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Compounds for genes affiliated with Localized Osteosarcoma

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Localized Osteosarcoma according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1acnu449.7TP53, CSF3
2amifostine44 1110.7CSF3, TP53
3taxane449.7CSF3, TP53
4bcnu449.6CSF3, TP53
52-chlorodeoxyadenosine449.6CSF3, TP53
6topotecan44 1110.6CSF3, TP53
7fludarabine44 1110.6CSF3, TP53
8melphalan44 1110.6CSF3, TP53
9vinblastine44 49 1111.6TP53, CSF3
10irinotecan44 49 1111.6CSF3, TP53
11carboplatin44 49 1111.6TP53, CSF3
12bleomycin44 1110.5CSF3, TP53
13gemcitabine44 49 1111.5CSF3, TP53
14hydroxyurea44 49 1111.5CSF3, TP53
15mitomycin c449.4CSF3, TP53
16cytarabine44 49 1111.4CSF3, TP53
17vincristine44 49 1111.3TP53, CSF3
18cyclophosphamide44 49 1111.3TP53, CSF3
19adriamycin449.2TP53, CSF3
20docetaxel44 49 59 1112.0TP53, CSF3

GO Terms for genes affiliated with Localized Osteosarcoma

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16Gene Ontology
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Biological processes related to Localized Osteosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.3TP53, CSF3

Products for genes affiliated with Localized Osteosarcoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Localized Osteosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet