MCID: LCL004
MIFTS: 39

Localized Osteosarcoma

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Localized Osteosarcoma

MalaCards integrated aliases for Localized Osteosarcoma:

Name: Localized Osteosarcoma 12 14 69
Localized Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3356
NCIt 47 C7780
UMLS 69 C0278511

Summaries for Localized Osteosarcoma

MalaCards based summary : Localized Osteosarcoma, also known as localized osteogenic sarcoma, is related to liposarcoma and heel spur. An important gene associated with Localized Osteosarcoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Pathways in cancer and Glucose / Energy Metabolism. The drugs Cisplatin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and liver, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Localized Osteosarcoma

Diseases related to Localized Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
id Related Disease Score Top Affiliating Genes
1 liposarcoma 10.7 CYP4V2 EWSR1
2 heel spur 10.5 EWSR1 TWIST1
3 exertional headache 10.5 CDKN2A CSF3 EWSR1
4 radioulnar synostosis with amegakaryocytic thrombocytopenia 1 10.5 GHR IGFBP3
5 protein s deficiency 10.3 GHR IGFBP3
6 hyperlipoproteinemia, type ib 10.2 IGF1R IGFBP3
7 cervical adenoid cystic carcinoma 10.2 CDKN2A TP53
8 split hand split foot nystagmus 10.2 CDKN2A TP53
9 leiomyoma cutis 10.2 CDKN2A TP53
10 anal squamous cell carcinoma 10.2 CDKN2A TP53
11 camptocormism 10.2 GLI2 TP53
12 rectum squamous cell carcinoma 10.2 CDKN2A TP53
13 male genital organ stricture 10.2 IGFBP3 TTR
14 breast myoepitheliosis 10.2 CDKN2A TP53
15 ritter's disease 10.2 CDKN2A TP53
16 rh isoimmunization 10.1 CSF3 TP53
17 coccidiosis 10.1 CDKN2A TP53
18 adenocarcinoma in situ 10.1 CDKN2A TP53
19 duodenum cancer 10.1 CDKN2A TP53
20 penis paget's disease 10.1 CDKN2A TP53
21 retinal detachment 10.1 CDKN2A TP53
22 larynx carcinoma in situ 10.1 CDKN2A TP53
23 phalanx chondroma 10.0 CDKN2A TP53
24 olfactory neural tumor 10.0 CDKN2A TP53
25 orbital lymphoma 10.0 CDKN2A TP53
26 heavy chain disease 10.0 CDKN2A GLI2 TP53
27 acute myocardial infarction 10.0 CDKN2A CSF3 TP53
28 non-suppurative otitis media 10.0 CDKN2A TP53
29 small cell sarcoma 9.9 CDKN2A EWSR1 TP53
30 accessory nerve disease 9.9 CDKN2A EWSR1 TP53
31 brown-vialetto-van laere syndrome 9.9 CDKN2A EWSR1 TP53
32 benign shuddering attacks 9.8 CDKN2A IGFBP3 TP53
33 bardet-biedl syndrome 9.8 CDKN2A IGFBP3 TP53
34 pancreatic agenesis 9.7 CDKN2A TP53
35 lung cancer susceptibility 2 9.6 GHR IGF1R IGFBP2 IGFBP3
36 cranioectodermal dysplasia 1 9.6 CDKN2A CSF3 RUNX2 TP53
37 primary optic atrophy 9.6 IGF1R IGFBP3 TP53
38 sarcoma 9.5
39 secondary pulmonary hemosiderosis 9.5 CDKN2A TP53
40 mantle cell lymphoma 9.5 CDKN2A IL13 TP53
41 small cell cancer of the lung, somatic 9.4 CDKN2A IGF1R RUNX2 TP53
42 giant cell glioblastoma 9.3 CDKN2A IGF1R TP53
43 telangiectatic glomangioma 9.3 CDKN2A IGF1R TP53
44 prostate rhabdomyosarcoma 9.3 EWSR1 IGF1R TP53
45 pediatric osteosarcoma 5.3 CARTPT CDKN2A CSF3 CYP4V2 EWSR1 GHR

Graphical network of the top 20 diseases related to Localized Osteosarcoma:



Diseases related to Localized Osteosarcoma

Symptoms & Phenotypes for Localized Osteosarcoma

MGI Mouse Phenotypes related to Localized Osteosarcoma:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 CARTPT CDKN2A CYP4V2 GHR GLI2 IGF1R
2 growth/size/body region MP:0005378 10.19 CDKN2A GHR GLI2 IGF1R IGFBP3 IL13
3 endocrine/exocrine gland MP:0005379 10.16 CARTPT CDKN2A GHR GLI2 IGF1R IGFBP3
4 hematopoietic system MP:0005397 10.13 CARTPT CDKN2A CSF3 GHR IGF1R IGFBP2
5 immune system MP:0005387 10.09 CARTPT CDKN2A CSF3 GHR IGF1R IGFBP2
6 cardiovascular system MP:0005385 10.08 GHR IGF1R IGFBP2 RUNX2 TP53 TWIST1
7 digestive/alimentary MP:0005381 10.07 GLI2 IGF1R IL13 RUNX2 TP53 TWIST1
8 integument MP:0010771 10.06 CDKN2A CSF3 GHR GLI2 IGF1R IGFBP3
9 muscle MP:0005369 9.91 CDKN2A GHR GLI2 IGF1R IGFBP3 IL13
10 liver/biliary system MP:0005370 9.87 IGFBP3 RUNX2 TP53 CDKN2A GHR IGF1R
11 limbs/digits/tail MP:0005371 9.85 GHR GLI2 IGF1R RUNX2 TP53 TWIST1
12 no phenotypic analysis MP:0003012 9.63 TP53 TTR CDKN2A GLI2 IL13 RUNX2
13 respiratory system MP:0005388 9.43 CDKN2A GLI2 IGF1R IL13 RUNX2 TP53
14 skeleton MP:0005390 9.28 TWIST1 CARTPT CDKN2A GHR GLI2 IGF1R

Drugs & Therapeutics for Localized Osteosarcoma

Drugs for Localized Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
2
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
3
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
4
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
5
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
6
Mechlorethamine Approved Phase 3,Phase 2,Phase 1 51-75-2 4033
7
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
9
Peginterferon alfa-2b Approved Phase 3 99210-65-8, 215647-85-1
10
Zoledronic acid Approved Phase 3 118072-93-8 68740
11
Cyproheptadine Approved Phase 3 129-03-3 2913
12
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
14
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 143 6006
15
Doxil Approved June 1999 Phase 3,Phase 2 31703
16 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
17 Anti-Bacterial Agents Phase 3,Phase 2
18 Alkylating Agents Phase 3,Phase 2,Phase 1
19 Antirheumatic Agents Phase 3,Phase 2,Phase 1
20 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
21 Anti-Infective Agents Phase 3,Phase 2
22 Liver Extracts Phase 3,Phase 1
23 Antiviral Agents Phase 3,Phase 2
24 Interferon-alpha Phase 3,Phase 2
25 interferons Phase 3,Phase 2
26 Adjuvants, Immunologic Phase 3,Phase 2
27 Antibiotics, Antitubercular Phase 3,Phase 2
28 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
29 Antimetabolites Phase 3,Phase 2
30 Antimetabolites, Antineoplastic Phase 3,Phase 2
31 Antimitotic Agents Phase 3,Phase 2
32 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
33 Dermatologic Agents Phase 3,Phase 2
34 Etoposide phosphate Phase 3,Phase 2,Phase 1
35 Folic Acid Antagonists Phase 3,Phase 2
36 Isophosphamide mustard Phase 3,Phase 2,Phase 1
37 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
38 Protective Agents Phase 3,Phase 2
39 razoxane Phase 3,Phase 2
40 Vitamin B Complex Phase 3,Phase 2
41 Antidotes Phase 3,Phase 2
42 Antioxidants Phase 3
43 Antitubercular Agents Phase 3
44 Chelating Agents Phase 3
45 sodium thiosulfate Phase 3
46 Adjuvants, Anesthesia Phase 3
47 Analgesics Phase 3,Phase 2
48 Analgesics, Opioid Phase 3
49 Anesthetics Phase 3
50 Anesthetics, General Phase 3

Interventional clinical trials:

(show all 33)

id Name Status NCT ID Phase Drugs
1 Combination Chemotherapy and Surgery With or Without G-CSF in Treating Patients With Osteosarcoma Completed NCT00002539 Phase 3 cisplatin;doxorubicin hydrochloride
2 Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma Completed NCT00003937 Phase 3 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate
3 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
4 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
5 Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children Completed NCT00180908 Phase 3 Etoposide, Ifosfamide, Methotrexate;Doxorubicin, Methotrexate
6 Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Active, not recruiting NCT00134030 Phase 3 doxorubicin hydrochloride;cisplatin;methotrexate;ifosfamide;etoposide
7 Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma Terminated NCT00470223 Phase 3 cisplatin;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate;zoledronic acid
8 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
9 Interferon Alfa and Thalidomide in Treating Patients With Soft Tissue Sarcoma or Bone Sarcoma Unknown status NCT00026416 Phase 2 thalidomide
10 Samarium Sm 153 and Stem Cell Transplant Followed By Radiation Therapy Patients With Osteosarcoma Completed NCT00245011 Phase 2 ifosfamide
11 Combination Chemotherapy and Radiation Therapy in Treating Patients With Peripheral Neuroectodermal Tumors, Ewing's Sarcoma, Wilms' Tumor, or Bone Cancer Completed NCT00002466 Phase 2 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
12 Osteosarcoma1999-A Study Of Intensive Chemotherapy for Osteosarcoma Completed NCT00145639 Phase 2 Ifosfamide, Carboplatin, Doxorubicin
13 A Placebo-Controlled Study of Saracatinib (AZD0530) in Patients With Recurrent Osteosarcoma Localized to the Lung Active, not recruiting NCT00752206 Phase 2 Saracatinib;Placebo
14 A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma Active, not recruiting NCT00667342 Phase 2 Cisplatin;Doxorubicin;Methotrexate;Ifosfamide;etoposide
15 Sorafenib and Ifosfamide in Treating Patients With High-Grade Soft Tissue Sarcoma or Bone Sarcoma That Can Be Removed by Surgery Terminated NCT00880542 Phase 2 sorafenib;Ifosfamide
16 Combination Chemotherapy Before and After Surgery in Treating Patients With Osteosarcoma Terminated NCT00019864 Phase 2 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;methotrexate
17 Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor Completed NCT00161187 Phase 1
18 High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Cancer Completed NCT00002854 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;mesna;paclitaxel
19 Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer Unknown status NCT00499733 cyclophosphamide
20 Combination Chemotherapy in Treating Patients Undergoing Surgery for Newly Diagnosed High-Grade Osteosarcoma Completed NCT00645632 cisplatin;doxorubicin hydrochloride;ifosfamide;methotrexate
21 Studying DNA in Tumor Tissue Samples From Patients With Localized or Metastatic Osteosarcoma Completed NCT01062438
22 Study of Blood Samples From Patients With Osteosarcoma Completed NCT00954473
23 Biomarker Expression in Tissue Samples From Patients With Bone Sarcomas Completed NCT01807052
24 Biomarkers in Predicting Response to Chemotherapy in Samples From Young Patients With Osteosarcoma Completed NCT01374672
25 PET Scan Combined With CT Scan in Evaluating Treatment Response in Patients Undergoing Treatment for Bone Cancer or Soft Tissue Sarcoma Completed NCT00335751
26 Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer Completed NCT00002485
27 Electroacupuncture in Treating Delayed Nausea and Vomiting in Patients Receiving Chemotherapy For Newly Diagnosed Childhood Sarcoma, Neuroblastoma, Nasopharyngeal Cancer, Germ Cell Tumors, or Hodgkin Lymphoma Completed NCT00040911
28 Genetic Study of Children With Soft Tissue Sarcoma or Rhabdomyosarcoma Completed NCT00003793
29 Detection of Circulating Osteosarcoma Tumor Cells in the Blood of Patients Using the Polymerase Chain Reaction Completed NCT00588510
30 Collecting and Storing Tissue From Young Patients With Cancer Recruiting NCT00898755
31 DNA Biomarkers in Tissue Samples From Patients With Osteosarcoma Active, not recruiting NCT01190943
32 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 glutamine
33 Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection Withdrawn NCT00378781 Heparin;Minocycline-EDTA

Search NIH Clinical Center for Localized Osteosarcoma

Genetic Tests for Localized Osteosarcoma

Anatomical Context for Localized Osteosarcoma

MalaCards organs/tissues related to Localized Osteosarcoma:

39
Bone, Lung, Liver, Endothelial

Publications for Localized Osteosarcoma

Articles related to Localized Osteosarcoma:

(show all 26)
id Title Authors Year
1
P16 expression as a prognostic and predictive marker in high grade localized osteosarcoma of the extremities: An analysis of 357 cases. ( 27544803 )
2016
2
Risk-Based Therapy for Localized Osteosarcoma. ( 26501936 )
2015
3
Developing a prognostic model for patients with localized osteosarcoma treated with uniform chemotherapy protocol without high dose methotrexate: A single-center experience of 237 patients. ( 26381138 )
2015
4
Characterization of localized osteosarcoma of the extremity in children, adolescents, and young adults from a single institution in South Texas. ( 24487915 )
2014
5
Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. ( 25106799 )
2014
6
Prognostic value of pathologic fracture in patients with high grade localized osteosarcoma: A systemic review and meta-analysis of cohort studies. ( 25231396 )
2014
7
Reply to the Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. ( 25099264 )
2014
8
Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study. ( 24178953 )
2013
9
Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. ( 22972657 )
2013
10
Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. ( 23226744 )
2012
11
Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. ( 21563300 )
2011
12
Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group. ( 21480474 )
2011
13
Frontline treatment of localized osteosarcoma without methotrexate: results of the St. Jude Children's Research Hospital OS99 trial. ( 21656756 )
2011
14
Intensive induction chemotherapy without methotrexate in adult patients with localized osteosarcoma: results of the Institut Gustave-Roussy phase II trial. ( 21151406 )
2010
15
Pharmacokinetic individualization of high-dose methotrexate chemotherapy for the treatment of localized osteosarcoma. ( 20566424 )
2010
16
How can survival be improved in localized osteosarcoma? ( 20735316 )
2010
17
Prognostic effect of pathologic fracture in localized osteosarcoma: a cohort/case controlled study at a single institute. ( 19294672 )
2009
18
Risk stratification based on the clinical factors at diagnosis is closely related to the survival of localized osteosarcoma. ( 19021220 )
2009
19
Tumor necrosis rate adjusted by tumor volume change is a better predictor of survival of localized osteosarcoma patients. ( 18163171 )
2008
20
Initial tumor size predicts histologic response and survival in localized osteosarcoma patients. ( 18270971 )
2008
21
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. ( 16246977 )
2005
22
The feasibility of neoadjuvant high-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with nonmetastatic high grade localized osteosarcoma: results of a phase II study. ( 15999369 )
2005
23
Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. ( 11516856 )
2001
24
Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. ( 11596036 )
2001
25
Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity. ( 11064353 )
2000
26
The treatment of localized osteosarcoma of the extremities: the Italian experience. Studies of the National Research Council. ( 1622856 )
1992

Variations for Localized Osteosarcoma

Expression for Localized Osteosarcoma

Search GEO for disease gene expression data for Localized Osteosarcoma.

Pathways for Localized Osteosarcoma

GO Terms for Localized Osteosarcoma

Cellular components related to Localized Osteosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CARTPT CSF3 GHR IGFBP2 IGFBP3 IL13

Biological processes related to Localized Osteosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.88 CDKN2A CSF3 GLI2 RUNX2 TP53 TWIST1
2 positive regulation of gene expression GO:0010628 9.65 RUNX2 TP53 TWIST1
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.5 CSF3 GHR TP53
4 osteoblast development GO:0002076 9.46 GLI2 RUNX2
5 insulin-like growth factor receptor signaling pathway GO:0048009 9.43 GHR IGF1R
6 response to mechanical stimulus GO:0009612 9.43 GLI2 IGFBP2 IL13
7 replicative senescence GO:0090399 9.37 CDKN2A TP53
8 regulation of insulin-like growth factor receptor signaling pathway GO:0043567 9.16 IGFBP2 IGFBP3
9 negative regulation of neuron death GO:1901215 9.13 CSF3 GHR IL13
10 osteoblast differentiation GO:0001649 8.92 GLI2 IGFBP3 RUNX2 TWIST1

Molecular functions related to Localized Osteosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.56 CDKN2A GLI2 TP53 TWIST1
2 insulin-like growth factor II binding GO:0031995 9.16 IGFBP2 IGFBP3
3 insulin-like growth factor binding GO:0005520 9.13 IGF1R IGFBP2 IGFBP3
4 insulin-like growth factor I binding GO:0031994 8.8 IGF1R IGFBP2 IGFBP3

Sources for Localized Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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