MCID: LCL006
MIFTS: 53

Localized Scleroderma malady

Categories: Genetic diseases, Rare diseases, Skin diseases, Immune diseases, Nephrological diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Localized Scleroderma

About this section
Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 65UMLS, 47Novoseek, 27ICD10, 29ICD9CM, 36MeSH, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Localized Scleroderma:

Name: Localized Scleroderma 10 45 12 51 65
Morphea 10 45 47 65
Localized Fibrosing Scleroderma 45 51
Scleroderma, Circumscribed or Localized 10
Unspecified Circumscribed Scleroderma 10
 
Circumscribed Scleroderma Nos 10
Circumscribed Scleroderma 10
Scleroderma, Localized 45
Localised Morphoea 10
Localized Morphea 10

Characteristics:

Orphanet epidemiological data:

51
localized scleroderma:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy

Classifications:

Orphanet: 51 
Rare skin diseases


External Ids:

Disease Ontology10 DOID:8472
ICD1027 L94.0
ICD9CM29 701.0
MeSH36 D012594
NCIt42 C72069
Orphanet51 90289
ICD10 via Orphanet28 L94.0
MESH via Orphanet37 D012594
UMLS via Orphanet66 C0036420
UMLS65 C0036420, C1527383

Summaries for Localized Scleroderma

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NIH Rare Diseases:45 Localized scleroderma is characterized by thickening of the skin from excessive collagen deposits. collagen is a protein normally present in our skin that provides structural support. however, when too much collagen is made, the skin becomes stiff and hard. localized types of scleroderma are those limited to the skin and related tissues and, in some cases, the muscle below. internal organs are not affected by localized scleroderma, and localized scleroderma can never progress to the systemic form of the disease. often, localized conditions improve or go away on their own over time, but the skin changes and damage that occur when the disease is active can be permanent. for some people, localized scleroderma is serious and disabling. there are two generally recognized types of localized scleroderma: morphea and linear.   last updated: 4/3/2012

MalaCards based summary: Localized Scleroderma, also known as morphea, is related to pulmonary hypertension and gingivitis, and has symptoms including dry skin, hypopigmented skin patches and skeletal muscle atrophy. An important gene associated with Localized Scleroderma is MMP1 (Matrix Metallopeptidase 1), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Syndecan-1-mediated signaling events. Affiliated tissues include skin, lung and liver, and related mouse phenotypes are vision/eye and respiratory system.

Wikipedia:68 Morphea, also known as \"localized scleroderma\", or \"circumscribed scleroderma\", involves isolated... more...

Related Diseases for Localized Scleroderma

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Diseases in the Systemic Scleroderma family:

localized scleroderma

Diseases related to Localized Scleroderma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary hypertension30.2DCN, TGFB1
2gingivitis29.6CTGF, DCN, MMP1, TGFB1
3systemic scleroderma11.8
4morpheaform basal cell carcinoma11.5
5reynolds syndrome10.6
6atrophoderma of pierini and pasini10.6
7linear scleroderma10.6
8progressive hemifacial atrophy10.4
9odontoma10.4DCN, MMP1
10keratoconus10.4MMP1, TGFB1
11recessive dystrophic epidermolysis bullosa-generalized other10.4MMP1, TGFB1
12neuronal ceroid-lipofuscinoses10.4DCN, MMP1
13humeroradial synostosis10.3MMP1, TGFB1
14nephronophthisis familial adult spastic quadriparesis10.3DCN, TGFB1
15episodic ataxia10.3CTGF, TGFB1
16laryngeal tuberculosis10.3CTGF, TGFB1
17secondary corneal edema10.3DCN, TGFB1
18corpus callosum agenesis double urinary collecting10.3MMP1, MMP13
19endotheliitis10.3
20retinitis pigmentosa 1710.3CTGF, TGFB1
21ophthalmia nodosa10.3CTGF, TGFB1
22chronic ulcer of skin10.2BMP6, TGFB1
23patau syndrome10.2CTGF, TGFB1
24breast fibroadenosis10.2BMP6, TGFB1
25oral candidiasis10.2CTGF, TGFB1
26suppurative uveitis10.2CTGF, TGFB1
27breast cancer10.2
28hepatitis10.2
29lymphoma10.2
30thyroiditis10.2
31neuronitis10.2
32umbilical hernia10.2MMP1, MMP13
33cystic echinococcosis10.1CTGF, MMP1, TGFB1
34lymph node adenoid cystic carcinoma10.1BMP6, CTGF
35atelosteogenesis ii10.1COL2A1, TGFB1
36bone resorption disease10.1COL2A1, MMP13
37cervicitis10.1
38pancreatitis10.1
39amyloidosis10.1
40trichorhinophalangeal syndrome, type ii10.1CTGF, MMP1, MMP13
41spondyloepimetaphyseal dysplasia10.1COL2A1, MMP13
42gastric cancer10.1
43peritonitis10.1
44cardiomyopathy10.1
45ectopia lentis, familial10.0BMP6, DCN, TGFB1
46sezary's disease10.0COL2A1, CTGF, TGFB1
47darier disease10.0COL2A1, MMP13
48malignant struma ovarii10.0CTGF, TGFB1
49aortic disease10.0BMP6, TGFB1
50oppositional defiant disorder10.0BMP6, CTGF, TGFB1

Graphical network of the top 20 diseases related to Localized Scleroderma:



Diseases related to localized scleroderma

Symptoms for Localized Scleroderma

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Symptoms:

 51 (show all 11)
  • anomalies of skin, subcutaneous tissue and mucosae
  • dry/squaly skin/exfoliation
  • dermal/subcutaneous infiltration/induration
  • irregular/patchy skin hypopigmentation
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • upper limb asymmetry/hemiatrophy/hemihypertrophy
  • claw hand/retracted fingers
  • lower limb asymmetry/hemiatrophy/hemihypertrophy
  • claw toes/retracted toes
  • musculo-tendinous retractions
  • asymmetry of the body/hemiatrophy/hemihyperthrophy

HPO human phenotypes related to Localized Scleroderma:

id Description Frequency HPO Source Accession
1 dry skin hallmark (90%) HP:0000958
2 hypopigmented skin patches hallmark (90%) HP:0001053
3 skeletal muscle atrophy typical (50%) HP:0003202
4 camptodactyly of toe occasional (7.5%) HP:0001836
5 lower limb asymmetry occasional (7.5%) HP:0100559

Drugs & Therapeutics for Localized Scleroderma

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Drugs for Localized Scleroderma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 85)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 46085
2
Tadalafilapproved, investigationalPhase 3140171596-29-5110635
Synonyms:
(6R,12AR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
(6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
171596-29-5
1xoz
6-BENZO[1,3]dioxol-5-yl-2-methyl-2,3,6,7,12,12a-hexahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
AC1L380B
ADCIRCA
Acdirca
Adcirca
C429886
CHEBI:41488
CHEMBL779
CID110635
CPD000466321
Cialis
Cialis (TN)
Cialis, GF 196960, IC 351, ICOS 351, Tadalafil
D02008
DB00820
FT-0080116
GF 196960
GF-196960
 
HMS2051N17
HSDB 7303
IC 351
IC-351
ICOS 351
Ic351
KS-1117
LS-186558
LS-187015
LS-187770
Lilly brand of tadalafil
MLS000759426
MLS001165782
MLS001195644
MLS001424132
MolPort-002-885-864
S1512_Selleck
SAM001246586
SMR000466321
Tadalafil
Tadalafil (JAN/USAN/INN)
Tadalafil [USAN]
Tadanafil
UNII-742SXX0ICT
ZINC03993855
3
Cyclophosphamideapproved, investigationalPhase 3, Phase 1, Phase 2264350-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
DB00531
 
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
4
LidocaineapprovedPhase 2, Phase 31103137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Afterburn
Akten
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bikini Zone Medicated
Bikini Zone Medicated Creme
Bio-0767
Bio-scriptives Lidum
Bio-scriptives Lidum Hemorroidal (anorectal)
Bio-scriptives Lidum Topical Analgesic
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
Burn Relief Leader
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Comfortcaine
Cuivasil
Curacaine Transdermal Corporation
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
Derma Numb
DermaFlex
Desert Harvest Releveum
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Dr. Numb
Dr. Richs Numbing
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gigi Anesthetic Numbing
Gravocain
H-releve Hemorrhoidal
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
Hawaiian Tropic
Hush Anesthetic
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
LS-805
Lanabiotic
 
Laryng-o-jet
Leostesin
Lida-Mantle
Lidall
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine 4% Cream
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Hydrochloride
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocaine hydrochloride
Lidocainum
Lidocainum [INN-Latin]
Lidocare Mist
Lidocaton
Lidocream 4
Lidocream 5
Lidoderm
Lidoderm 5
Lidoject-1
Lidoject-2
Lifestyles Epic Male Genital Desensitizer
Lignocaine
Lignocainum
Lingocaine
Lmx4
Lmx5
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Numb Master Topical Anesthetic
Numb Nuts
Ocean Potion Instant Burn Relief Ice
Octocaine
Octocaine-100
Octocaine-50
Plum Smooth Plumb Numb Gelee
Premjact Male Desensitizer Pound International
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Recticare
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Simplicity Desensitizing
Simply Numb Endure
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Sole Serum
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Walgreens Aloe Vera Pain Relieving
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocaine-mpf
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zcaine Fast Acting Anesthetic
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
5
Imiquimodapproved, investigationalPhase 313199011-02-657469
Synonyms:
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine
1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
3M Brand of Imiquimod
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline
4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
99011-02-6
AC-529
AC1L1N2I
AC1Q4YO9
Aldara
Aldara (TN)
Aldara, Imiquimod
BB_SC-2107
BIDD:GT0859
Beselna
C056493
CHEBI:36704
CHEMBL1282
CID57469
D02500
DB00724
DZ-2636
FT-0080222
HMS2090M14
I06-0624
 
I06-2289
I0747
I5159_SIGMA
IMIQUIMOD
Imiquimod
Imiquimod (JAN/USAN/INN)
Imiquimod [USAN:INN]
Imiquimod acetate
Imiquimodum
LS-178395
MLS000083577
MTD-39
MolPort-002-507-845
NCGC00070736-02
NSC369100
R 837
R-837
S 26308
S-26308
S1211_Selleck
SMR000048307
STK583860
TL8006059
TMX-101
UNII-P1QW714R7M
Vyloma
ZINC19632912
Zartra
Zyclara
imiquimod
6
AcetylcholineexperimentalPhase 368951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
7Central Nervous System DepressantsPhase 2, Phase 310016
8Anti-Arrhythmia AgentsPhase 2, Phase 32371
9Anesthetics, LocalPhase 2, Phase 32347
10AnestheticsPhase 2, Phase 37385
11Diuretics, Potassium SparingPhase 2, Phase 31445
12interferonsPhase 31930
13Adjuvants, ImmunologicPhase 31783
14lenograstimPhase 31134
15Sodium Channel BlockersPhase 2, Phase 31180
16Peripheral Nervous System AgentsPhase 2, Phase 318510
17Pharmaceutical SolutionsPhase 2, Phase 37004
18Phosphodiesterase InhibitorsPhase 31062
19Phosphodiesterase 5 InhibitorsPhase 3513
20Contraceptives, OralPhase 3, Phase 23734
21Immunosuppressive AgentsPhase 3, Phase 1, Phase 210422
22Vasodilator AgentsPhase 32926
23Sildenafil CitratePhase 3304171599-83-0
24Immunologic FactorsPhase 3, Phase 1, Phase 218483
25Antineoplastic Agents, AlkylatingPhase 3, Phase 23406
26Antirheumatic AgentsPhase 3, Phase 1, Phase 28496
27Alkylating AgentsPhase 3, Phase 23582
28insulinPhase 34278
29IncobotulinumtoxinAPhase 3599
30Insulin, Globin ZincPhase 34278
31Neuromuscular AgentsPhase 3922
32OnabotulinumtoxinAPhase 3588
33Neurotransmitter AgentsPhase 314795
34Cholinergic AgentsPhase 33243
35Botulinum Toxins, Type APhase 3588
36AbobotulinumtoxinAPhase 3588
37Botulinum ToxinsPhase 3616
38
Citric AcidnutraceuticalPhase 3100177-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
39CitrateNutraceuticalPhase 31001
40
AbataceptapprovedPhase 1, Phase 2139332348-12-610237
Synonyms:
CTLA4-Ig
CTLA4-IgG4m
 
CTLA4Ig
CTLA4IgG4m
Orencia
41
Treprostinilapproved, investigationalPhase 27781846-19-754786, 6918140
Synonyms:
((1R,2R,3aS,9aS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate
(1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-hexahydro-2-hydroxy- 1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl] oxy]acetic acid
({(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl}oxy)acetic acid
15 AU81
15AU81
2-[[(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid
2-[[(1S,2S,3aR,9aR)-2-hydroxy-1-[(3R)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid
289480-64-4 (Sodium salt)
81846-19-7
AC1L1HPX
AC1OCF2J
CHEBI:50861
CID11246284
CID54786
CID6918140
CID9800580
D06213
DB00374
L001079
LRX 15
 
LS-177654
LS-187014
LS-187645
Orenitram
Remodulin
Remodulin (TN)
Treprostinil
Treprostinil (USAN/INN)
Treprostinil [USAN:INN]
Treprostinil sodium
Treprostinilo
Treprostinilum
Tyvaso
U 62840
U-62,840
UNII-RUM6K67ESG
UT-15
Uniprost
Viveta
[[(1R,2R,3aS,9aS)-2-Hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphtalen-5-yl]oxy]acetic acid
treprostinilo
treprostinilum
42
Mycophenolate mofetilapproved, investigationalPhase 2898128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate Mofetil
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil
43
Mycophenolic acidapprovedPhase 289824280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
Melbex
 
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolic Acid
Mycophenolsaeure
Myfortic
44
Bosentanapproved, investigationalPhase 2100147536-97-8104865
Synonyms:
-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
147536-97-8
174227-18-0
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
AC-148
AC1L2XN2
Actelion
Bosentan
Bosentan (INN)
Bosentan [USAN:INN:BAN]
Bosentan hydrate
Bosentanum
C27H29N5O6S
CHEBI:51450
CHEMBL957
CID104865
D07538
 
DB00559
EN002863
HMS2090N14
I06-1873
KS-5062
L001086
LS-31532
MolPort-003-845-300
NCGC00167440-01
P-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
PDSP1_001731
PDSP2_001714
Ro 47-0203
Ro 47-0203/039
Ro-47-0203
Ro-47-0203/029
Ro-47-0203/039
TL8001039
Tracleer
UNII-XUL93R30K2
bosentanum
p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
p-tert-Butyl-N-[6-(2-hydroxyethoxy)
45
rituximabapprovedPhase 21582174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
46
BenzocaineapprovedPhase 216841994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
20/20 Topical Anesthetic
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Alcohol Prep Pads
Allegenal-m
Alpha-caine Topical Anesthetic
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anbesol Jr
Anbesol Maximum Strength
Anbesol Regular Strength
Anestenka
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthetic
Anesthone
Atopalm Oral Pain Relief
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Baby Anestenka
Baby Sensigel
Baby Sensigel Night Time Formula
Baby Teething Oral Pain Reliever
Bactimicina For Sore Throat
Bencocaine Topical Anesthetic
Bensokain
Benz O Sthetic
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzodent
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
Boil Ease
Boy Butter Desensitizing Lubricant
Boy Butter Extreme Desensitizing Lubricant
Boy Butter Extreme H2O Desensitizing Lubricant
Brace Relief
Budpak Baby Teething Oral Pain Reliever
Budpak Oral Maximum Strength
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Carmex Cold Sore Treatment External Analgesic
Caswell No. 430A
Cepacol Fizzlers
Cepacol Sensations Hydra
Cepacol Sensations Sore Throat Hydra citrus splash
Cepacol Sensations Warming
Certus Sting Relief Prep Pad
Chloraseptic
Chloraseptic Warming Sore Throat
Colgate Orabase
Comfortcaine Topical Anesthetic
Cvs Fast Acting Baby Teething
Cvs Maximum Strength
Cvs Maximum Strength Boil Relief
Cvs Oral Anesthetic
Cvs Pharmacy Instant Toothache
Cvs Pharmacy Maximum Strength
Cvs Pharmacy Mouth Sore Gel
Cvs Pharmacy Nighttime Oral Pain Relief
D001566
D00552
DB01086
Dental Relief
Dentek Instant Pain Relief Maximum Strength
Dermoplast
Diet Ayds
DivK1c_000932
Dollar General Toothache Relief
Dukal Sting Relief Pad
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Finafta Baby
Finafta MultiOral
Formate, Benzocaine
Gelato Topical Anesthetic
Good Neighbor Pain Relief
Goodsense Oral Pain Relief
Gps Topical Anesthetic
Gumnumb Topical Anesthetic
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Heb Severe Toothache
Herbasoul Male Genital Desensitizer Cream
 
Hurricaine
Hurricaine Topical Anesthetic
Hurricaine Topical Anesthetic Gel
Hurricaine Topical Anesthetic Liquid
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
Insect Bite Relief
Instant Toothache Pain Relief
Intense Cvs Intense Toothache
Iodent Maximum Strength Oral Analgesic
Ismile Topical Anesthetic
Jianze Sting Relief Pads
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Kank-a Mouth Pain
Keloform
Kmart Smart Sense
Kroger Toothache Pain Relief
LS-35847
Leader Oral Analgesic
Little Colds Sore Throat Relief Melt Aways
MLS001331704
MLS002153970
Makesense Junior Pain Relief
Makesense Pain Relief
Male Desensitizer Pleasure Balm
Mandelay Male Genital Desensitizer
Mark 3
Methanesulfonate, Benzocaine
MolPort-000-871-526
Mouth Sore Medication
Mouth Sore Relief Applicator
Mouth Sore Relief Professional Strength
My Fair Baby Instant Pain Relief
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Nene Dente
Norcain
Norcaine
Norcainum
Opahl
Opahl Dye Free
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orajel For All Mouth Sores Maximum Strength
Orajel For Cold Sores
Orajel For Toothache Maximum Strength
Orajel Instant Pain Relief Maximum Strength
Orajel Instant Pain Relief Regular Strength
Orajel Instant Relief For Teething Pain
Orajel Instant Relief For Teething Pain Cooling Cucumber
Orajel Instant Relief For Teething Pain Daytime Nighttime Twin Pack
Orajel Instant Relief For Teething Pain Longer Lasting
Orajel Maximum Strength
Orajel Nighttime Instant Relief For Teething Pain Longer Lasting Extra Strength
Orajel Severe Toothache Maximum Strength Fast-Acting Formula
Oral Analgesic Maximum Strength
Oral B Instant Pain Relief
Oral Gel Maximum Strength
Oral Pain Relief Anesthetic Anesthetic
Oral Pain Reliever
Oralabs Cold Sore Treatment
Orthesin
Otocain
Outgro
Pac-dent Top Gel
Pain Relief
Pain Relief Alcohol Swabs
Parathesin
Parathesin (TN)
Parathesine
Physicians Care Sting Relief Pad
Pleasure Balm Kama Sutra
Preboost
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
Purelife Topical Anesthetic
Quality Choice Maximum Strength Oral Pain Relieving
Red Cross Oral Pain Relief
Rexall Maximum Strength
Rite Aid Baby Care
Rite Aid Liquid Anesthetic Oral Pain Relief
Rite Aid Maximum Strength
Rite Aid Oral Pain Reliever
Rite Aid Professional Strength
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Sally Hansen Ouch-relief Numbing Wipes
Sally Hansen Ouch-relief Wax Kit
Sally Hansen Ouch-relief Wax Strip Kit
Sensigel
Severe Oral Pain Reliever
Sheffield Baby Teething Gel
Sheffield Pain Relief
Shunga Male Genital Desensitizer
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Sting Relief Medicated Pad
Sting Relief Pads
Tanac
Terrasil Boil Pain Relief
Tiger Supply Inc Topical Anesthetic
Top Quality Mfg. Topical Anesthetic
Topcaine
Topcare Maximum Strength
Topical Anesthetic Banana
Topical Anesthetic Bubble Gum
Topical Anesthetic Cherry
Topical Anesthetic Mint
Topical Anesthetic Pina Colada
Topical Anesthetic Raspberry
Topical Anesthetic Strawberry
UNII-U3RSY48JW5
Ultracare Anesthetic Bubble Gum
Ultracare Anesthetic Butter Rum
Ultracare Anesthetic Creme de Menthe
Ultracare Anesthetic Pina Colada
Ultracare Anesthetic Walterberry
WLN: ZR DVO2
Walgreens Baby Teething
Walgreens Intense Toothache
Walgreens Maximum Strength
Walgreens Pain Relieving For Boils
Walgreens Severe Oral Pain Reliever
Walgreens Severe Toothache Relief
Winco Foods Maximum Strength Oral Analgesic
ZINC12358719
Zilactin-b
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
47Anti-Bacterial AgentsPhase 29140
48Antibiotics, AntitubercularPhase 25971
49TezosentanPhase 264
50Protein Kinase InhibitorsPhase 23162

Interventional clinical trials:

(show top 50)    (show all 54)
idNameStatusNCT IDPhase
1Influenza Vaccination in Patients With SclerodermaNot yet recruitingNCT01002508Phase 4
2Imiquimod in Children With Plaque MorpheaCompletedNCT00147771Phase 3
3Sildenafil Effect on Digital Ulcer Healing in sClerodErma SEDUCE STUDYCompletedNCT01295736Phase 3
4Scleroderma Lung DiseaseCompletedNCT00004563Phase 3
5A Randomized Control Trial to Assess the Efficacy of Tadalafil in Raynaud's Phenomenon in SclerodermaCompletedNCT01117298Phase 3
6Effectiveness and Safety of Lidocaine for SclerodermaCompletedNCT00740285Phase 2, Phase 3
7High Dose Cyclophosphamide for Treatment of SclerodermaCompletedNCT00501995Phase 3
8Efficacy of Botulinum Toxin In Scleroderma-Associated Raynaud's SyndromeActive, not recruitingNCT02165111Phase 3
9Imiquimod 5% Cream in Plaque-type Morphea: A Pilot, Prospective Open-label StudyWithdrawnNCT00230373Phase 3
10Efficacy and Safety of Imatinib in SclerodermaCompletedNCT00479934Phase 2
11Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal MatrixCompletedNCT00129428Phase 1, Phase 2
12Digital Ischemic Lesions in Scleroderma Treated With Oral Treprostinil DiethanolamineCompletedNCT00775463Phase 2
13Psychological Treatments for SclerodermaCompletedNCT00007267Phase 2
14A Study to Evaluate the Safety and Efficacy of Abatacept in Patients With Diffuse Systemic Sclerosis (Scleroderma)CompletedNCT00442611Phase 1, Phase 2
15Oral Type I Collagen for Relieving SclerodermaCompletedNCT00005675Phase 2
16Treatment of Refractory Sever Systemic Scleroderma by Injection of Allogeneic Mesenchymal Stem CellsRecruitingNCT02213705Phase 1, Phase 2
17Zibotentan Better Renal Scleroderma Outcome StudyRecruitingNCT02047708Phase 2
18A Protocol Based Treatment for Debilitating Fibrosing Skin Disorders With (Anti-CD 20), Rituximab, Evaluating Safety and EfficacyActive, not recruitingNCT00936546Phase 2
19Effect of Bosentan in Scleroderma Renal CrisisActive, not recruitingNCT01241383Phase 2
20Comparison of Therapeutic Regimens for Scleroderma Interstitial Lung Disease (The Scleroderma Lung Study II)Active, not recruitingNCT00883129Phase 2
21Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial HypertensionNot yet recruitingNCT02682511Phase 2
22Proof of Concept Trial of Gleevec (Imatinib) in Active Diffuse SclerodermaTerminatedNCT01545427Phase 2
23Placebo Controlled Trial of Bosentan in Scleroderma PatientsTerminatedNCT00377455Phase 2
24A Pilot Study to Evaluate Topical Sodium Thiosulfate Therapy for Calcinosis CutisWithdrawnNCT01918904Phase 2
25Safety, Tolerability and Pharmacokinetic Study of MRG-201 in Healthy Volunteers and Patients With Cutaneous SclerodermaRecruitingNCT02603224Phase 1
26Comparative Effectiveness Trial in the Treatment of Pediatric Plaque MorpheaNot yet recruitingNCT02680717Phase 1
27Treatment Study Comparing Medium or High Dose Uva-1 Treatment 3x/Week Versus Fluocinonide 0.05% Cream in the Treatment of Morphea.CompletedNCT00812188
28The CARRA RegistryCompletedNCT01697254
29UVA1 Light for Treatment of Scleroderma and Similar ConditionsCompletedNCT00476801
30A Non-Interventional Pilot Study Assessing Whether Lysyl Oxidase-like 2 (LOXL2) is Present in Subjects With SclerodermaCompletedNCT01881529
31Sleep Disturbances and Pulmonary Artery/Aorta Diameter in Scleroderma PatientCompletedNCT00566137
32Morbidity and Mortality Follow Up for the Scleroderma Lung StudyCompletedNCT01762449
33Finger Hardness Measure in SclerodermaCompletedNCT01111786
34Multi-center, Web Based Observational Study of Pulmonary Hypertension in Scleroderma PatientsCompletedNCT00377949
35Scleroderma Lung: Role of Gastroesophageal Reflux, Microaspiration and CoughCompletedNCT01667042
36Genesis of Scleroderma: Role of Environmental Factors in 100 Patients With Scleroderma and 300 ControlsCompletedNCT00213525
37Premature Coronary Atherosclerosis in SclerodermaCompletedNCT00372398
38Pulmonary Involvement in Scleroderma: A Clinical Study of the Safety and Efficacy of Mycophenolate Mofetil in Scleroderma Patients With Lung InvolvementCompletedNCT00333437
39Study of Silicone-Associated Connective Tissue DiseasesCompletedNCT00001330
40Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA RepositoryRecruitingNCT01808937
41Fractional Carbon Dioxide Laser Versus UVA 1 in Treatment of Localized SclerodermaRecruitingNCT02002897
42Genetic Variants in Linear Localized SclerodermaRecruitingNCT02222038
43Treatment Study Comparing UVA-1 Phototherapy Versus Placebo Treatment for MorpheaRecruitingNCT01799174
44Microvascular and Fibrosis Imaging StudyRecruitingNCT01758250
45Pilot Study of the Effect of Laser on Reversing Chronic Radiation InjuryRecruitingNCT01910818
46Scleroderma Registry & Repository at the Hospital for Special SurgeryRecruitingNCT01656447
47Calcinosis in a Single-Center Scleroderma PopulationRecruitingNCT02062125
48Obstructive Sleep Apnea in Scleroderma and Pulmonary InvolvementRecruitingNCT02740569
49Prevention and Treatment of Digital Ulcers in Systemic SclerosisRecruitingNCT01836263
50Vasculopathy, Inflammation and Systemic SclerosisRecruitingNCT02562079

Search NIH Clinical Center for Localized Scleroderma

Genetic Tests for Localized Scleroderma

About this section

Anatomical Context for Localized Scleroderma

About this section

MalaCards organs/tissues related to Localized Scleroderma:

33
Skin, Lung, Liver, Bone, T cells, Breast, Endothelial

Animal Models for Localized Scleroderma or affiliated genes

About this section

MGI Mouse Phenotypes related to Localized Scleroderma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6COL2A1, CTGF, DCN, ITGB5, TGFB1
2MP:00053888.3COL2A1, CTGF, DCN, FGG, TGFB1
3MP:00053907.9BMP6, COL2A1, CTGF, DCN, MMP13, TGFB1
4MP:00053787.1BMP6, COL2A1, CTGF, DCN, FGG, MMP13
5MP:00053856.9ARHGEF1, COL2A1, CTGF, FGG, ITGB5, MMP13
6MP:00053876.9ARHGEF1, COL2A1, DCN, FGG, ITGB5, MMP1
7MP:00053766.5ARHGEF1, COL2A1, CTGF, DCN, FGG, ITGB5

Publications for Localized Scleroderma

About this section

Articles related to Localized Scleroderma:

(show top 50)    (show all 344)
idTitleAuthorsYear
1
Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma : A matched-pair multicenter analysis of outcomes. (27215563)
2016
2
BRCA1 gene-related hereditary susceptibility to breast and ovarian cancer in Latvia. (24797986)
2014
3
Interrogation of ERG gene rearrangements in prostate cancer identifies a prognostic 10-gene signature with relevant implication to patients' clinical outcome. (24006850)
2014
4
Coronary artery aneurysm occurring very late after drug-eluting stent implantation. (25164132)
2014
5
The nerve growth factor receptor CD271 is crucial to maintain tumorigenicity and stem-like properties of melanoma cells. (24799129)
2014
6
Ovulation induction in the management of anovulatory polycystic ovary syndrome. (23084977)
2013
7
AGGF1 is a novel anti-inflammatory factor associated with TNF-I+-induced endothelial activation. (23628701)
2013
8
Contact cheilitis caused by candelilla wax contained in lipstick. (23869737)
2013
9
Intraosseous hemangioma of the appendicular skeleton: imaging features of 15 cases, and a review of the literature. (22736082)
2012
10
Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review. (20706138)
2011
11
A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo. (20498851)
2010
12
Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. (20439756)
2010
13
Activation of naive NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. (20351186)
2010
14
Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis. (19298637)
2009
15
Utero-relaxant effect of PDE4-selective inhibitor alone and in simultaneous administration with beta2-mimetic on oxytocin-induced contractions in pregnant myometrium. (19215543)
2009
16
Syringopleural shunt as a rescue procedure in patients with syringomyelia refractory to restoration of cerebrospinal fluid flow. (19687691)
2009
17
Proteomic profiling of rat lung epithelial cells induced by acrolein. (19490921)
2009
18
High postnatal oxidative stress in neonatal cystic periventricular leukomalacia. (19091500)
2009
19
Why does menopausal hormone therapy lead to irregular uterine bleeding? Changes to endometrial blood vessels. (18216041)
2008
20
Selenocysteine, soluble liver antigen/liver-pancreas, and autoimmune hepatitis. (17596869)
2007
21
Neuro-hormonal activation predicts ventilatory response to exercise and functional capacity in patients with heart failure. (16112902)
2006
22
EGFR amplification and lack of activating mutations in metaplastic breast carcinomas. (16739104)
2006
23
Effect of aminopeptidase inhibitor on differentiation induction activity of all-trans retinoic acid in human acute promyelocytic leukemia NB4 cells and its mechanism]. (16800923)
2006
24
A lymphotactin-producing monoclonal T-cell lymphoproliferative disorder with extreme lymphocytopenia and progressive leukoencephalopathy. (16923584)
2006
25
Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications. (15778860)
2005
26
Fasting hyperglucagonemia in patients with transjugular intrahepatic portosystemic shunts (TIPS). (15926112)
2005
27
Acute pH-dependent regulation of AE2-mediated anion exchange involves discrete local surfaces of the NH2-terminal cytoplasmic domain. (15452108)
2004
28
SjAPgren-Larsson syndrome: seven novel mutations in the fatty aldehyde dehydrogenase gene ALDH3A2. (15241804)
2004
29
Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo. (15297967)
2004
30
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Variations for Localized Scleroderma

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Expression for genes affiliated with Localized Scleroderma

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Search GEO for disease gene expression data for Localized Scleroderma.

Pathways for genes affiliated with Localized Scleroderma

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Pathways related to Localized Scleroderma according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathwaysScoreTop Affiliating Genes
19.9DCN, MMP1
29.8MMP1, TGFB1
39.7CTGF, TGFB1
49.6COL2A1, DCN
59.3DCN, ITGB5, TGFB1
69.3COL2A1, MMP1, MMP13
7
Show member pathways
9.2COL2A1, MMP1, MMP13
89.1BMP6, CTGF, TGFB1
98.9FGG, MMP13, TGFB1
108.8ARHGEF1, DCN, ITGB5, TGFB1
118.7BMP6, COL2A1, DCN, TGFB1
128.6BMP6, COL2A1, MMP13, TGFB1
13
Show member pathways
8.6COL2A1, FGG, ITGB5
14
Show member pathways
8.0ARHGEF1, COL2A1, ITGB5, MMP1, MMP13, TGFB1
15
Show member pathways
7.6ARHGEF1, BMP6, COL2A1, CTGF, ITGB5, TGFB1
16
Show member pathways
7.4ARHGEF1, BMP6, CTGF, ITGB5, MMP1, MMP13
17
Show member pathways
7.3COL2A1, DCN, FGG, ITGB5, MMP1, MMP13

GO Terms for genes affiliated with Localized Scleroderma

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Biological processes related to Localized Scleroderma according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1response to glucoseGO:000974910.1CTGF, TGFB1
2response to woundingGO:000961110.1CTGF, TGFB1
3cartilage condensationGO:000150210.1COL2A1, CTGF
4tissue homeostasisGO:000189410.1COL2A1, CTGF
5chondrocyte differentiationGO:000206210.0COL2A1, TGFB1
6inner ear developmentGO:00488399.9COL2A1, TGFB1
7positive regulation of SMAD protein import into nucleusGO:00603919.9BMP6, TGFB1
8SMAD protein signal transductionGO:00603959.9BMP6, TGFB1
9positive regulation of protein secretionGO:00507149.9BMP6, TGFB1
10positive regulation of bone mineralizationGO:00305019.8BMP6, TGFB1
11positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.8BMP6, TGFB1
12growthGO:00400079.8BMP6, TGFB1
13cellular response to BMP stimulusGO:00717739.7BMP6, COL2A1
14platelet degranulationGO:00025769.6FGG, TGFB1
15skeletal system developmentGO:00015019.5BMP6, COL2A1
16collagen catabolic processGO:00305749.5COL2A1, MMP13
17endochondral ossificationGO:00019589.5BMP6, COL2A1, MMP13
18cartilage developmentGO:00512169.2BMP6, COL2A1, MMP13
19ossificationGO:00015039.2BMP6, COL2A1, CTGF
20cell-matrix adhesionGO:00071609.2CTGF, FGG, ITGB5
21extracellular matrix disassemblyGO:00226179.0COL2A1, DCN, MMP1, MMP13

Sources for Localized Scleroderma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet