MCID: LWC001
MIFTS: 35

Low Compliance Bladder

Categories: Nephrological diseases

Aliases & Classifications for Low Compliance Bladder

MalaCards integrated aliases for Low Compliance Bladder:

Name: Low Compliance Bladder 12 14 69
Hyperactivity of Bladder 12
Hypertonicity of Bladder 12
Low Bladder Compliance 12
Hypertonic Bladder 12
Overactive Bladder 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12144
ICD9CM 35 596.52
SNOMED-CT 64 9009001
UMLS 69 C0489967

Summaries for Low Compliance Bladder

MalaCards based summary : Low Compliance Bladder, also known as hyperactivity of bladder, is related to epithelial predominant pulmonary blastoma and subclavian steal syndrome, and has symptoms including dysuria, prostatism and lower urinary tract symptoms. An important gene associated with Low Compliance Bladder is RAB34 (RAB34, Member RAS Oncogene Family), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Amphetamine addiction. The drugs Alkylating Agents and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related phenotype is Decreased viability in esophageal squamous lineage.

Related Diseases for Low Compliance Bladder

Diseases related to Low Compliance Bladder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
id Related Disease Score Top Affiliating Genes
1 epithelial predominant pulmonary blastoma 10.3 ALDH7A1 PDE5A
2 subclavian steal syndrome 10.2 CALM1 CALM2 CALM3
3 long qt syndrome 15 10.2 CALM1 CALM2 CALM3
4 epidural spinal canal meningioma 10.2 CALM1 CALM2 CALM3
5 heterotaxy, visceral, 8, autosomal 10.2 CALM1 CALM2 CALM3
6 pseudohypoaldosteronism, type iic 10.2 CALM1 CALM2 CALM3
7 mononeuritis of lower limb 10.2 CALM1 CALM2 CALM3
8 pontiac fever 10.2 CALM1 CALM2 CALM3
9 regular astigmatism 10.2 CALM1 CALM2 CALM3
10 dumping syndrome 10.2 CALM1 CALM2 CALM3
11 bulimia nervosa, age of onset of weight loss in 10.2 CALM1 CALM2 CALM3
12 leber congenital amaurosis 2 10.1 CALM1 CALM2 CALM3
13 alkhurma hemorrhagic fever 10.1 CALM1 CALM2 CALM3
14 cardiomyopathy, dilated, 1a 10.1 CALM1 CALM2 CALM3
15 cardiomyopathy, hypertrophic, 18 10.1 CALM1 CALM2 CALM3
16 partial of retinal vein occlusion 10.1 CALM1 CALM2 CALM3
17 plantar fasciitis 10.0 CALM1 CALM2 CALM3
18 deafness, autosomal dominant 2a 10.0 CALM1 CALM2 CALM3
19 hypochromic microcytic anemia 10.0 CALM1 CALM2 CALM3
20 pigment dispersion syndrome 9.9 CALM1 CALM2 CALM3
21 umbilical hernia 9.8 CALM1 CALM2 CALM3
22 hydronephrosis 9.7
23 cystitis 9.7
24 ureteral obstruction 9.7
25 jervell and lange-nielsen syndrome 9.6 CALM1 CALM2 CALM3
26 lymphocytic choriomeningitis 4.2 ALDH7A1 ALPP BCL2L10 CALM1 CALM2 CALM3

Comorbidity relations with Low Compliance Bladder via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Low Compliance Bladder:



Diseases related to Low Compliance Bladder

Symptoms & Phenotypes for Low Compliance Bladder

UMLS symptoms related to Low Compliance Bladder:


dysuria, prostatism, lower urinary tract symptoms

GenomeRNAi Phenotypes related to Low Compliance Bladder according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.32 ALPP BCL2L10 CALM1 CALM3 MAPK8IP1 MEOX2

Drugs & Therapeutics for Low Compliance Bladder

Drugs for Low Compliance Bladder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Alkylating Agents Phase 2
2 Anti-Bacterial Agents Phase 2
3 Antibiotics, Antitubercular Phase 2
4 Mitomycins Phase 2
5 Nucleic Acid Synthesis Inhibitors Phase 2
6
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741 24759

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction Recruiting NCT02859844 Phase 3
2 Investigating Bladder Chemotherapy Instead of Surgery for Low Risk Bladder Cancer Recruiting NCT02070120 Phase 2 Mitomycin C
3 Efficacy of Endoscopic Subureteral Injection for Vesicoureteral Reflux in Adults With Decreased Bladder Compliance Completed NCT00815334

Search NIH Clinical Center for Low Compliance Bladder

Genetic Tests for Low Compliance Bladder

Anatomical Context for Low Compliance Bladder

MalaCards organs/tissues related to Low Compliance Bladder:

39
Spinal Cord

Publications for Low Compliance Bladder

Articles related to Low Compliance Bladder:

id Title Authors Year
1
Low compliance bladder. ( 27343340 )
2016
2
Video-urodynamic effects of mirabegron, a I^3 -adrenoceptor agonist, in patients with low-compliance bladder. ( 26177781 )
2015
3
Low compliance bladder plays a role in hydronephrosis in lupus cystitis: a case report. ( 24596124 )
2014
4
Laparoscopic diverticulocystoplasty for low compliance bladder in a child. ( 23318084 )
2012
5
Efficacy of extended-release tolterodine for the treatment of neurogenic detrusor overactivity and/or low-compliance bladder. ( 20969642 )
2010
6
Botulinum toxin type A injections for treating neurogenic detrusor overactivity combined with low-compliance bladder in patients with spinal cord lesions. ( 16271557 )
2005
7
Significance of low compliance bladder in cauda equina injury. ( 12483499 )
2002
8
Initial clinical experience with the selective phosphodiesterase-I isoenzyme inhibitor vinpocetine in the treatment of urge incontinence and low compliance bladder. ( 11204266 )
2000
9
Gastrocystoplasty in a woman with radiation-induced ureteral obstruction and low-compliance bladder. ( 9792987 )
1998

Variations for Low Compliance Bladder

Expression for Low Compliance Bladder

Search GEO for disease gene expression data for Low Compliance Bladder.

Pathways for Low Compliance Bladder

Pathways related to Low Compliance Bladder according to GeneCards Suite gene sharing:

(show all 36)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 CALM1 CALM2 CALM3 P2RX1 P2RX2 P2RX3
2
Show member pathways
11.91 CALM1 CALM2 CALM3
3
Show member pathways
11.9 CALM1 CALM2 CALM3
4
Show member pathways
11.86 CALM1 CALM2 CALM3
5 11.84 CALM1 CALM2 CALM3
6 11.84 CALM1 CALM2 CALM3
7
Show member pathways
11.81 CALM1 CALM2 CALM3
8
Show member pathways
11.78 CALM1 CALM2 CALM3
9
Show member pathways
11.77 CALM1 CALM2 CALM3
10
Show member pathways
11.74 CALM1 CALM2 CALM3
11
Show member pathways
11.71 CALM1 CALM2 CALM3
12
Show member pathways
11.7 CALM1 CALM2 CALM3
13
Show member pathways
11.7 CALM1 CALM2 CALM3 P2RX1 P2RX2 P2RX3
14
Show member pathways
11.67 CALM1 CALM2 CALM3
15 11.67 CALM1 CALM2 CALM3
16
Show member pathways
11.66 CALM1 CALM2 CALM3
17 11.64 CALM1 CALM2 CALM3
18
Show member pathways
11.59 CALM1 CALM2 CALM3
19 11.57 CALM1 CALM2 CALM3
20 11.54 CALM1 CALM2 CALM3
21
Show member pathways
11.53 CALM1 CALM2 CALM3
22 11.44 CALM1 CALM2 CALM3
23
Show member pathways
11.44 CALM1 CALM2 CALM3 P2RX1 P2RX2 P2RX3
24 11.27 CALM1 CALM2 CALM3
25 11.26 CALM1 CALM2 CALM3
26 11.23 CALM1 CALM2 CALM3
27 11.2 CALM1 CALM2 CALM3
28 11.19 CALM1 CALM2 CALM3
29 11.14 CALM1 CALM2 CALM3
30 11.1 CALM1 CALM2 CALM3
31 11.07 CALM1 CALM2 CALM3
32 11.04 CALM1 CALM2 CALM3
33 10.89 CALM1 CALM2 CALM3
34 10.78 CALM1 CALM2 CALM3
35 10.71 CALM1 CALM2 CALM3
36 10.45 CALM1 CALM2 CALM3

GO Terms for Low Compliance Bladder

Cellular components related to Low Compliance Bladder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
2 postsynapse GO:0098794 9.33 P2RX1 P2RX2 P2RX3
3 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
4 integral component of nuclear inner membrane GO:0005639 8.8 P2RX1 P2RX2 P2RX3

Biological processes related to Low Compliance Bladder according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 response to organic substance GO:0010033 9.81 P2RX1 P2RX2 P2RX3
2 excitatory postsynaptic potential GO:0060079 9.78 P2RX1 P2RX2 P2RX3
3 cation transmembrane transport GO:0098655 9.77 P2RX1 P2RX2 P2RX3
4 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
5 positive regulation of protein serine/threonine kinase activity GO:0071902 9.75 CALM1 CALM2 CALM3
6 regulation of heart rate GO:0002027 9.74 CALM1 CALM2 CALM3
7 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.73 CALM1 CALM2 CALM3
8 positive regulation of protein dephosphorylation GO:0035307 9.72 CALM1 CALM2 CALM3
9 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.71 CALM1 CALM2 CALM3
10 positive regulation of protein autophosphorylation GO:0031954 9.7 CALM1 CALM2 CALM3
11 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.69 CALM1 CALM2 CALM3
12 regulation of cardiac muscle contraction GO:0055117 9.67 CALM1 CALM2 CALM3
13 response to ATP GO:0033198 9.65 P2RX1 P2RX2 P2RX3
14 positive regulation of calcium-mediated signaling GO:0050850 9.64 P2RX2 P2RX3
15 positive regulation of calcium ion transport into cytosol GO:0010524 9.63 P2RX2 P2RX3
16 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.63 CALM1 CALM2 CALM3
17 response to carbohydrate GO:0009743 9.62 P2RX2 P2RX3
18 behavioral response to pain GO:0048266 9.62 P2RX2 P2RX3
19 peristalsis GO:0030432 9.61 P2RX2 P2RX3
20 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.61 CALM1 CALM2 CALM3
21 urinary bladder smooth muscle contraction GO:0014832 9.58 P2RX2 P2RX3
22 detection of calcium ion GO:0005513 9.58 CALM1 CALM2 CALM3
23 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.54 CALM1 CALM2 CALM3
24 purinergic nucleotide receptor signaling pathway GO:0035590 9.5 P2RX1 P2RX2 P2RX3
25 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
26 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
27 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
28 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Low Compliance Bladder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.77 CALM1 CALM2 CALM3 LAX1 MAPK8IP1
2 ion channel binding GO:0044325 9.58 CALM1 CALM2 CALM3
3 protein serine/threonine kinase activator activity GO:0043539 9.5 CALM1 CALM2 CALM3
4 titin binding GO:0031432 9.43 CALM1 CALM2 CALM3
5 extracellular ATP-gated cation channel activity GO:0004931 9.33 P2RX1 P2RX2 P2RX3
6 purinergic nucleotide receptor activity GO:0001614 9.13 P2RX1 P2RX2 P2RX3
7 protein phosphatase activator activity GO:0072542 8.8 CALM1 CALM2 CALM3

Sources for Low Compliance Bladder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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