MCID: LWC001
MIFTS: 30

Low Compliance Bladder

Categories: Nephrological diseases

Aliases & Classifications for Low Compliance Bladder

MalaCards integrated aliases for Low Compliance Bladder:

Name: Low Compliance Bladder 12 14 69
Hyperactivity of Bladder 12
Hypertonicity of Bladder 12
Low Bladder Compliance 12
Hypertonic Bladder 12
Overactive Bladder 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12144
ICD9CM 34 596.52
SNOMED-CT 64 9009001

Summaries for Low Compliance Bladder

MalaCards based summary : Low Compliance Bladder, also known as hyperactivity of bladder, is related to hydronephrosis and cystitis, and has symptoms including lower urinary tract symptoms, prostatism and urgency of micturition. An important gene associated with Low Compliance Bladder is CHRM3 (Cholinergic Receptor Muscarinic 3), and among its related pathways/superpathways are Peptide ligand-binding receptors and Taste transduction. Affiliated tissues include prostate and spinal cord.

Related Diseases for Low Compliance Bladder

Diseases related to Low Compliance Bladder via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hydronephrosis 9.8
2 cystitis 9.8
3 ureteral obstruction 9.8
4 neurogenic bladder 9.5 P2RX1 P2RX2
5 bladder disease 9.4 CHRM3 P2RX2

Comorbidity relations with Low Compliance Bladder via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Low Compliance Bladder:



Diseases related to Low Compliance Bladder

Symptoms & Phenotypes for Low Compliance Bladder

UMLS symptoms related to Low Compliance Bladder:


lower urinary tract symptoms, prostatism, urgency of micturition, dysuria

Drugs & Therapeutics for Low Compliance Bladder

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction Recruiting NCT02859844

Search NIH Clinical Center for Low Compliance Bladder

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Low Compliance Bladder

Anatomical Context for Low Compliance Bladder

MalaCards organs/tissues related to Low Compliance Bladder:

38
Prostate, Spinal Cord

Publications for Low Compliance Bladder

Articles related to Low Compliance Bladder:

# Title Authors Year
1
Low compliance bladder. ( 27343340 )
2016
2
Video-urodynamic effects of mirabegron, a I^3 -adrenoceptor agonist, in patients with low-compliance bladder. ( 26177781 )
2015
3
Low compliance bladder plays a role in hydronephrosis in lupus cystitis: a case report. ( 24596124 )
2014
4
Laparoscopic diverticulocystoplasty for low compliance bladder in a child. ( 23318084 )
2012
5
Efficacy of extended-release tolterodine for the treatment of neurogenic detrusor overactivity and/or low-compliance bladder. ( 20969642 )
2010
6
Botulinum toxin type A injections for treating neurogenic detrusor overactivity combined with low-compliance bladder in patients with spinal cord lesions. ( 16271557 )
2005
7
Significance of low compliance bladder in cauda equina injury. ( 12483499 )
2002
8
Initial clinical experience with the selective phosphodiesterase-I isoenzyme inhibitor vinpocetine in the treatment of urge incontinence and low compliance bladder. ( 11204266 )
2000
9
Gastrocystoplasty in a woman with radiation-induced ureteral obstruction and low-compliance bladder. ( 9792987 )
1998

Variations for Low Compliance Bladder

Expression for Low Compliance Bladder

Search GEO for disease gene expression data for Low Compliance Bladder.

Pathways for Low Compliance Bladder

GO Terms for Low Compliance Bladder

Cellular components related to Low Compliance Bladder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.46 ADRB3 CHRM3 P2RX1 P2RX2
2 receptor complex GO:0043235 9.26 ADRB3 P2RX2
3 postsynapse GO:0098794 8.96 P2RX1 P2RX2
4 integral component of nuclear inner membrane GO:0005639 8.62 P2RX1 P2RX2

Biological processes related to Low Compliance Bladder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to organic substance GO:0010033 9.4 P2RX1 P2RX2
2 cation transmembrane transport GO:0098655 9.37 P2RX1 P2RX2
3 excitatory postsynaptic potential GO:0060079 9.32 P2RX1 P2RX2
4 regulation of vasoconstriction GO:0019229 9.26 CHRM3 P2RX1
5 response to ATP GO:0033198 9.16 P2RX1 P2RX2
6 purinergic nucleotide receptor signaling pathway GO:0035590 8.96 P2RX1 P2RX2
7 regulation of vascular smooth muscle contraction GO:0003056 8.62 CHRM3 P2RX1

Molecular functions related to Low Compliance Bladder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.26 P2RX1 P2RX2
2 drug binding GO:0008144 9.16 CHRM3 P2RX1
3 extracellularly ATP-gated cation channel activity GO:0004931 8.96 P2RX1 P2RX2
4 purinergic nucleotide receptor activity GO:0001614 8.62 P2RX1 P2RX2

Sources for Low Compliance Bladder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....