MCID: LWC001
MIFTS: 30

Low Compliance Bladder malady

Categories: Nephrological diseases

Aliases & Classifications for Low Compliance Bladder

Aliases & Descriptions for Low Compliance Bladder:

Name: Low Compliance Bladder 12 14 69
Hyperactivity of Bladder 12
Hypertonicity of Bladder 12
Low Bladder Compliance 12
Hypertonic Bladder 12
Overactive Bladder 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12144
ICD9CM 35 596.52
SNOMED-CT 64 9009001
UMLS 69 C0489967

Summaries for Low Compliance Bladder

MalaCards based summary : Low Compliance Bladder, also known as hyperactivity of bladder, is related to brain injury and hydronephrosis, and has symptoms including dysuria, prostatism and lower urinary tract symptoms. An important gene associated with Low Compliance Bladder is CHRM3 (Cholinergic Receptor Muscarinic 3), and among its related pathways/superpathways are Peptide ligand-binding receptors and Taste transduction. The drugs Acetylcholine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include prostate and spinal cord.

Related Diseases for Low Compliance Bladder

Diseases related to Low Compliance Bladder via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 brain injury 9.9 CHRM3 P2RX2
2 hydronephrosis 9.7
3 cystitis 9.7
4 ureteral obstruction 9.7
5 alveolar echinococcosis 9.5 MEOX2 P2RX1 P2RX2
6 lymphocytic choriomeningitis 9.0 ADRB3 CHRM3 MEOX2 P2RX1 P2RX2 RAB34

Comorbidity relations with Low Compliance Bladder via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Low Compliance Bladder:



Diseases related to Low Compliance Bladder

Symptoms & Phenotypes for Low Compliance Bladder

UMLS symptoms related to Low Compliance Bladder:


dysuria, prostatism, lower urinary tract symptoms

Drugs & Therapeutics for Low Compliance Bladder

Drugs for Low Compliance Bladder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 3 51-84-3 187
2 Cholinergic Agents Phase 3
3 Neuromuscular Agents Phase 3
4 Neurotransmitter Agents Phase 3
5 Anesthetics Phase 3
6 Peripheral Nervous System Agents Phase 3
7 abobotulinumtoxinA Phase 3
8 incobotulinumtoxinA Phase 3
9 onabotulinumtoxinA Phase 3
10 Botulinum Toxins Phase 3
11 Botulinum Toxins, Type A Phase 3
12 Alkylating Agents Phase 2
13 Mitomycins Phase 2
14 Nucleic Acid Synthesis Inhibitors Phase 2
15 Anti-Bacterial Agents Phase 2
16 Antibiotics, Antitubercular Phase 2
17
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741 24759
18
Ethanol Approved 64-17-5 702
19
Epinephrine Approved, Vet_approved 51-43-4 5816
20 Epinephryl borate
21 Racepinephrine

Interventional clinical trials:


id Name Status NCT ID Phase
1 Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction Recruiting NCT02859844 Phase 3
2 Children Toxine Botulinum Detrusor Injection in Neurogenic Vesical Hyperactivity Syndrom: Non Inferiority Multicenter Controlled Therapeutic Study Between Two Reported Weight's Doses Recruiting NCT02816151 Phase 3
3 Investigating Bladder Chemotherapy Instead of Surgery for Low Risk Bladder Cancer Recruiting NCT02070120 Phase 2
4 Efficacy of Endoscopic Subureteral Injection for Vesicoureteral Reflux in Adults With Decreased Bladder Compliance Completed NCT00815334
5 The Efficacy and Safety of Fotona Smooth® Device for the Treatment of Stress Urinary Incontinence Recruiting NCT03098992
6 Electrical Nerve Stimulation for Overactive Bladder a Comparison of Treatments Enrolling by invitation NCT01940367

Search NIH Clinical Center for Low Compliance Bladder

Genetic Tests for Low Compliance Bladder

Anatomical Context for Low Compliance Bladder

MalaCards organs/tissues related to Low Compliance Bladder:

39
Prostate, Spinal Cord

Publications for Low Compliance Bladder

Articles related to Low Compliance Bladder:

id Title Authors Year
1
Low compliance bladder. ( 27343340 )
2016
2
Video-urodynamic effects of mirabegron, a I^3 -adrenoceptor agonist, in patients with low-compliance bladder. ( 26177781 )
2015
3
Low compliance bladder plays a role in hydronephrosis in lupus cystitis: a case report. ( 24596124 )
2014
4
Laparoscopic diverticulocystoplasty for low compliance bladder in a child. ( 23318084 )
2012
5
Efficacy of extended-release tolterodine for the treatment of neurogenic detrusor overactivity and/or low-compliance bladder. ( 20969642 )
2010
6
Botulinum toxin type A injections for treating neurogenic detrusor overactivity combined with low-compliance bladder in patients with spinal cord lesions. ( 16271557 )
2005
7
Significance of low compliance bladder in cauda equina injury. ( 12483499 )
2002
8
Initial clinical experience with the selective phosphodiesterase-I isoenzyme inhibitor vinpocetine in the treatment of urge incontinence and low compliance bladder. ( 11204266 )
2000
9
Gastrocystoplasty in a woman with radiation-induced ureteral obstruction and low-compliance bladder. ( 9792987 )
1998

Variations for Low Compliance Bladder

Expression for Low Compliance Bladder

Search GEO for disease gene expression data for Low Compliance Bladder.

Pathways for Low Compliance Bladder

GO Terms for Low Compliance Bladder

Cellular components related to Low Compliance Bladder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.46 ADRB3 CHRM3 P2RX1 P2RX2
2 receptor complex GO:0043235 9.26 ADRB3 P2RX2
3 postsynapse GO:0098794 8.96 P2RX1 P2RX2
4 integral component of nuclear inner membrane GO:0005639 8.62 P2RX1 P2RX2

Biological processes related to Low Compliance Bladder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to organic substance GO:0010033 9.4 P2RX1 P2RX2
2 cation transmembrane transport GO:0098655 9.37 P2RX1 P2RX2
3 excitatory postsynaptic potential GO:0060079 9.32 P2RX1 P2RX2
4 regulation of vasoconstriction GO:0019229 9.26 CHRM3 P2RX1
5 response to ATP GO:0033198 9.16 P2RX1 P2RX2
6 purinergic nucleotide receptor signaling pathway GO:0035590 8.96 P2RX1 P2RX2
7 regulation of vascular smooth muscle contraction GO:0003056 8.62 CHRM3 P2RX1

Molecular functions related to Low Compliance Bladder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.26 P2RX1 P2RX2
2 drug binding GO:0008144 9.16 CHRM3 P2RX1
3 extracellular ATP-gated cation channel activity GO:0004931 8.96 P2RX1 P2RX2
4 purinergic nucleotide receptor activity GO:0001614 8.62 P2RX1 P2RX2

Sources for Low Compliance Bladder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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