MCID: LWR010
MIFTS: 46

Low Renin Hypertension malady

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Summaries for Low Renin Hypertension

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MalaCards: Low Renin Hypertension is related to hypertension and hyperaldosteronism. An important gene associated with Low Renin Hypertension is CYP11B2 (cytochrome P450, family 11, subfamily B, polypeptide 2), and among its related pathways are superpathway of steroid hormone biosynthesis and Metabolism of steroid hormones and vitamin D. The compounds 18-hydroxycorticosterone and 11b-Hydroxyandrost-4-ene-3,17-dione have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and adrenal gland, and related mouse phenotypes are renal/urinary system and normal.

Aliases & Classifications for Low Renin Hypertension

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47OMIM, 45Novoseek, 62UMLS
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Aliases & Descriptions:

low renin hypertension 47 45 62


Related Diseases for Low Renin Hypertension

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17GeneCards, 18GeneDecks
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Diseases related to Low Renin Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.5CCL2, REN, ADD1, HSD11B2, CYP11B1, CYP11B2
2hyperaldosteronism30.8CYP11B1, HSD11B2, REN, CYP11B2
3glucocorticoid-remediable aldosteronism30.3CYP11B1, REN, CYP11B2
4essential hypertension30.3CYP11B1, CYP11B2, EDN1, HSD11B2, SOD1, NOS3
5adenoma30.3HSD11B2, REN, CYP11B1, CYP11B2
6proteinuria30.0NOS3, EDN1, OLR1, CCL2, REN, ADD1
7blindness10.3
8acromegaly10.2
9nephrosclerosis10.2
10apparent mineralocorticoid excess syndrome10.2
11familial hyperaldosteronism10.2
12endotheliitis10.2
13gitelman syndrome10.1REN
14hypoaldosteronism10.1CYP11B2, REN
15renal hypertension10.1EDN1, REN
16hepatorenal syndrome10.1EDN1, REN
17adrenocortical carcinoma10.1CYP11B2, CYP11B1
18acute chest syndrome10.1NOS3
19hypokalemia10.1REN, CYP11B2, HSD11B2
20conn's syndrome10.1CYP11B1, CYP11B2, REN
21congenital adrenal hyperplasia10.1CYP11B1, REN, CYP11B2
22congestive heart failure10.1REN, CYP11B2, EDN1
23pneumoconiosis10.1SOD1
24prinzmetal's variant angina10.1EDN1, NOS3
25addison's disease10.1CYP11B2, REN
26coronary artery vasospasm10.1EDN1, NOS3
27adrenal adenoma10.0REN, CYP11B1
28hepatopulmonary syndrome10.0NOS3, EDN1
29impotence10.0EDN1, NOS3
30cushing's syndrome10.0CYP11B2, REN, HSD11B2, CYP11B1
31glomerulosclerosis10.0CCL2, EDN1, REN
32primary hyperoxaluria10.0ADD1, REN, EDN1
33interstitial lung disease10.0CCL2, EDN1
34portal hypertension10.0NOS3, EDN1
35renal fibrosis10.0REN, CCL2
36stroke, ischemic10.0NOS3, EDN1, REN
37polycystic kidney disease, autosomal dominant10.0ADD1, REN, NOS3
38hypercholesterolemia10.0OLR1, NOS3, EDN1
39anthracosis10.0SOD1, CCL2
40liver cirrhosis10.0EDN1, REN, HSD11B2, NOS3
41congenital heart disease10.0REN, NOS3, CYP11B2, EDN1
42hypertrophy of breast10.0NOS3, EDN1, CYP11B2, REN
43chronic granulomatous disease10.0CYBB, SOD1
44systemic scleroderma10.0NOS3, CCL2, EDN1
45proliferative diabetic retinopathy10.0EDN1, CCL2
46coronary artery disease10.0OLR1, ADD1, NOS3, EDN1
47pulmonary fibrosis10.0EDN1, CCL2, SOD1
48vitiligo10.0GCH1, SOD1
49cork-handlers' disease10.0CCL2, SOD1, EDN1
50cerebrovascular disease10.0NOS3, CYP11B1, OLR1, REN, ADD1

Graphical network of the top 20 diseases related to Low Renin Hypertension:



Diseases related to low renin hypertension

Symptoms for Low Renin Hypertension

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Drugs & Therapeutics for Low Renin Hypertension

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Low Renin Hypertension

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Anatomical Context for Low Renin Hypertension

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33MalaCards
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MalaCards organs/tissues related to Low Renin Hypertension:

33
Testes, Endothelial, Adrenal gland, Cortex, Adrenal cortex

Animal Models for Low Renin Hypertension or affiliated genes

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37MGI
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Publications for Low Renin Hypertension

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52PubMed
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Articles related to Low Renin Hypertension:

(show top 50)    (show all 114)
idTitleAuthorsYear
1
Myocardial remodeling in low-renin hypertension: molecular pathways to cellular injury in relative aldosteronism. (19895752)
2009
2
Molecular and clinical investigations in patients with low-renin hypertension. (18704622)
2009
3
Letter regarding article by Hood et al, "The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio". (18250276)
2008
4
Low renin hypertension (LRH): shades of John Laragh. (18353670)
2008
5
The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio. (17606839)
2007
6
Monogenic forms of low-renin hypertension. (17066054)
2006
7
Reduced NAD(P)H oxidase in low renin hypertension: link among angiotensin II, atherogenesis, and blood pressure. (16344366)
2006
8
Low-renin hypertension with relative aldosterone excess is associated with impaired NO-mediated vasodilation. (16172426)
2005
9
Effects of eplerenone versus losartan in patients with low-renin hypertension. (16169319)
2005
10
Endogenous ouabain and acute salt loading in low-renin hypertension. (16053985)
2005
11
Low renin hypertensive states: perspectives, unsolved problems, future research. (15808808)
2005
12
Endothelin-aldosterone interaction and proteinuria in low-renin hypertension. (15076164)
2004
13
The syndromes of low-renin hypertension: "separating the wheat from the chaff". (15761538)
2004
14
-344C/T polymorphism of CYP11B2 gene in Italian patients with idiopathic low renin hypertension. (11587161)
2001
15
A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22). (11073536)
2000
16
Low renin hypertension in the next millennium. (10651217)
2000
17
T594M mutation in the ENaC beta subunit and low-renin hypertension in blacks. (10469873)
1999
18
A genetic defect resulting in mild low-renin hypertension. (9707624)
1998
19
Artificial mutations in P450c11AS (aldosterone synthase) can increase enzymatic activity: a model for low-renin hypertension? (7883820)
1995
20
Morphology and function of mesenteric resistance arteries in transgenic rats with low-renin hypertension. (1335000)
1992
21
Defects in cortisol metabolism causing low-renin hypertension. (1879383)
1991
22
Increased activity of digoxin-like substance in low-renin hypertension in acromegaly. (2196126)
1990
23
Alterations in aldosterone secretion and metabolism in low renin hypertension. (2229301)
1990
24
Natriuretic hormones in low renin hypertension. (2439743)
1987
25
Dopamine reduces aldosterone and 18-hydroxycorticosterone response to angiotensin II in patients with essential low-renin hypertension and idiopathic hyperaldosteronism. (3882312)
1985
26
Evidence for a circulating endogenous Na+-K+ pump inhibitor in low-renin hypertension. (2411605)
1985
27
Evidence for a circulating sodium-potassium pump inhibitor in low renin hypertension. (3893806)
1985
28
Endogenous sodium-potassium pump inhibitor in low renin hypertension. (3001753)
1985
29
The vascular Na+-K+ pump in low renin hypertension. (6204161)
1984
30
Fatal, low renin hypertension associated with a disturbance of cortisol metabolism. (6362571)
1983
31
Sodium-potassium pump in low-renin hypertension. (6303176)
1983
32
Natriuretic hormone--the missing link in low renin hypertension? (6756413)
1982
33
Role of a humoral sodium-potassium pump inhibitor in experimental low renin hypertension. (6280009)
1982
34
Partial characterization of unusual polar steroids in the urine of a child with low renin hypertension. (6283272)
1982
35
Prorenin measurements and sensitivity to spironolactone: a clinical tool for pathophysiological characterization of low-renin hypertension. (7013758)
1981
36
Studies on the role of a humoral sodium-transport inhibitor and the anteroventral third ventricle (AV3V) in experimental low-renin hypertension. (7032830)
1981
37
Implication of endogenous prostaglandin system in the antihypertensive effect of captopril, SQ 14225, in low renin hypertension. (6993721)
1980
38
Role of prostaglandin in the antihypertensive mechanism of captopril in low renin hypertension. (7004721)
1980
39
Efficacy of captopril in experimental low renin hypertension. (7009165)
1980
40
Is low-renin hypertension an overdiagnosed syndrome? (624453)
1978
41
Low-renin hypertension: classification, mechanisms and therapy. (352521)
1978
42
The characterization of low renin hypertension by plasma renin activity and plasma aldosterone concentration. (750601)
1978
43
Plasma aldosterone response to ACTH in primary aldosteronism and in patients with low renin hypertension. (225341)
1978
44
Low renin hypertension. (891220)
1977
45
Cardiovascular complications in low renin hypertension. (895500)
1977
46
Low renin hypertension--is it a stage of essential hypertension? (867421)
1977
47
Low renin hypertension. (1096763)
1975
48
Body-fluid volume in low-renin hypertension. (4136048)
1974
49
Prognosis in low renin hypertension. (4682227)
1973
50
Low renin hypertension and the adrenal cortex. (4339423)
1972

Variations for Low Renin Hypertension

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Expression for genes affiliated with Low Renin Hypertension

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Low Renin Hypertension

Search GEO for disease gene expression data for Low Renin Hypertension.

Pathways for genes affiliated with Low Renin Hypertension

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 51PharmGKB, 60Thomson Reuters
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Pathways related to Low Renin Hypertension according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
estradiol biosynthesis II38
androgen biosynthesis38
estradiol biosynthesis I38
progesterone biosynthesis38
9.9CYP11B1, CYP11B2
2
Show member pathways
9.9CYP11B1, CYP11B2
39.9EDN1, HSD11B2
4
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism38
9.6HSD11B2, CYP11B1, CYP11B2
59.6NOS3, EDN1
6
Show member pathways
9.4GCH1, NOS3
79.3NOS3, CCL2
8
Show member pathways
9.3NOS3, REN, CYP11B2
99.1EDN1, CYBB, NOS3
10
Show member pathways
9.0NOS3, SOD1
11
Show member pathways
9.0NOS3, SOD1

Compounds for genes affiliated with Low Renin Hypertension

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45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Low Renin Hypertension according to GeneCards/GeneDecks:

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idCompoundScoreTop Affiliating Genes
118-hydroxycorticosterone45 2411.0CYP11B1, REN, CYP11B2
211b-Hydroxyandrost-4-ene-3,17-dione2410.0HSD11B2, CYP11B2, CYP11B1
311 deoxycortisol4510.0REN, CYP11B1, CYP11B2
4hydralazine45 51 1112.0EDN1, CYP11B2, REN
5cortisol29 2411.0CYP11B1, CYP11B2, HSD11B2
618-oxocortisol459.9CYP11B1, CYP11B2
7atenolol45 51 29 24 1113.9EDN1, REN, CYP11B2
8cortisone45 2410.8HSD11B2, CYP11B2, CYP11B1
9metoclopramide45 51 1111.8CYP11B2, REN, CYP11B1
10doca459.8CYP11B2, HSD11B2, CYP11B1, REN
1111beta-hydroxysteroid459.7REN, HSD11B2, CYP11B1, CYP11B2
1217-hydroxyprogesterone45 2410.7CYP11B2, CYP11B1, REN
13hydrochlorothiazide45 29 51 24 1113.7CYP11B2, REN, ADD1, HSD11B2
14valsartan45 61 29 1112.7EDN1, CCL2, REN
15androstenedione45 2410.7CYP11B2, REN, HSD11B2, CYP11B1
16carbenoxolone45 29 1111.6EDN1, REN, HSD11B2
17hydrocortisone45 3 61 1112.6REN, HSD11B2, CYP11B1, CYP11B2
18irbesartan45 29 51 1112.6REN, CCL2, CYP11B2, EDN1
19spironolactone45 61 29 51 1113.4CYP11B1, ADD1, REN, CYP11B2, HSD11B2
20corticosterone45 61 2411.2CYP11B2, CYP11B1, CCL2, REN, HSD11B2
21potassium45 24 1111.2HSD11B2, CYP11B2, CYP11B1, ADD1, REN
22candesartan45 51 29 1112.2REN, CCL2, CYP11B2, NOS3
23losartan45 51 29 1112.2REN, EDN1, OLR1, CCL2, CYP11B2
24adma459.1EDN1, CCL2, OLR1, NOS3
25sodium45 2410.0EDN1, REN, ADD1, CYP11B2, CYP11B1, HSD11B2
26probucol45 1110.0CCL2, EDN1, SOD1
27carvedilol45 51 29 1112.0NOS3, REN, EDN1
28atorvastatin45 51 29 24 1113.0EDN1, NOS3, CCL2, OLR1
29ang ii459.0REN, CCL2, EDN1, NOS3, CYP11B2
30cgmp45 299.9GCH1, NOS3, REN, EDN1
31ng-nitro-l-arginine458.9NOS3, EDN1, SOD1
32nitroglycerin45 119.8SOD1, NOS3, REN, EDN1
33n(g)-nitro-l-arginine methyl ester458.8SOD1, OLR1, EDN1, NOS3
34norepinephrine45 24 1110.8GCH1, CCL2, REN, HSD11B2, CYP11B2, EDN1
35sodium nitroprusside458.8REN, NOS3, SOD1, EDN1
36dexamethasone45 51 29 1111.7REN, CCL2, CYP11B1, CYBB, CYP11B2, HSD11B2
37apocynin45 619.7EDN1, CYBB, SOD1, NOS3
38cholesterol45 29 24 1111.5ADD1, CYP11B2, CYP11B1, HSD11B2, REN, CCL2
39tetrahydrobiopterin45 24 1110.5SOD1, GCH1, NOS3
40diphenyleneiodonium458.5SOD1, NOS3, CYBB, CCL2
41prostacyclin458.3SOD1, NOS3, CCL2, REN, EDN1
428-isoprostane458.2NOS3, CCL2, EDN1, CYBB, SOD1
43indomethacin45 29 61 1111.1NOS3, OLR1, REN, SOD1, CYBB, EDN1
44glucose458.0CYP11B2, HSD11B2, ADD1, CCL2, GCH1, OLR1
45superoxide45 248.7OLR1, SOD1, NOS3, CYBB, GCH1, CCL2
46nadph45 248.5OLR1, SOD1, CYBB, HSD11B2, CCL2, GCH1
47calcium45 51 24 1110.4ADD1, REN, EDN1, NOS3, CCL2, GCH1
48oxygen45 247.6NOS3, GCH1, OLR1, CCL2, SOD1, HSD11B2
49nitric oxide45 24 118.6SOD1, EDN1, CYBB, CYP11B2, NOS3, ADD1
50arginine456.3CYP11B1, OLR1, CCL2, REN, SOD1, HSD11B2

GO Terms for genes affiliated with Low Renin Hypertension

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16Gene Ontology
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Cellular components related to Low Renin Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.7CCL2, SOD1, CYBB
2extracellular regionGO:0055767.9OLR1, CCL2, REN, SOD1, EDN1

Biological processes related to Low Renin Hypertension according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood volume by renal aldosteroneGO:00201710.3HSD11B2, CYP11B2
2cortisol biosynthetic processGO:03465110.3CYP11B2, CYP11B1
3aldosterone biosynthetic processGO:03234210.3CYP11B1, CYP11B2
4mineralocorticoid biosynthetic processGO:00670510.3CYP11B2, CYP11B1
5cellular response to potassium ionGO:03586510.3CYP11B1, CYP11B2
6C21-steroid hormone biosynthetic processGO:00670010.2CYP11B1, CYP11B2
7glucocorticoid biosynthetic processGO:00670410.2CYP11B1, HSD11B2
8sterol metabolic processGO:01612510.2CYP11B1, CYP11B2
9cellular response to hormone stimulusGO:03287010.0CYP11B1, CYP11B2
10maternal process involved in parturitionGO:06013710.0EDN1, CCL2
11regulation of systemic arterial blood pressure by endothelinGO:0031009.9EDN1, NOS3
12response to amino acidGO:0432009.9CCL2, EDN1
13response to lipopolysaccharideGO:0324969.8GCH1, REN, EDN1
14cellular response to interleukin-1GO:0713479.7EDN1, CCL2
15nitric oxide biosynthetic processGO:0068099.7NOS3, GCH1
16regulation of nitric-oxide synthase activityGO:0509999.7NOS3, GCH1
17response to hypoxiaGO:0016669.6EDN1, HSD11B2, CCL2
18nitric oxide metabolic processGO:0462099.6NOS3, GCH1
19negative regulation of blood pressureGO:0457769.6GCH1, NOS3
20hydrogen peroxide biosynthetic processGO:0506659.6CYBB, SOD1
21neutrophil chemotaxisGO:0305939.6EDN1, CCL2
22superoxide metabolic processGO:0068019.5SOD1, CYBB
23lipopolysaccharide-mediated signaling pathwayGO:0316639.5CCL2, NOS3
24interaction with hostGO:0517019.4CYBB, NOS3
25superoxide anion generationGO:0425549.3EDN1, CYBB, SOD1
26in utero embryonic developmentGO:0017019.3EDN1, ADD1, NOS3
27response to hydrogen peroxideGO:0425429.3SOD1, OLR1
28phagosome maturationGO:0903829.1NOS3, CYBB
29response to heatGO:0094088.9NOS3, CCL2, SOD1
30response to drugGO:0424938.8SOD1, CYBB, CCL2, HSD11B2
31regulation of blood pressureGO:0082178.4CYP11B1, SOD1, NOS3, GCH1, REN

Molecular functions related to Low Renin Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid 11-beta-monooxygenase activityGO:0045079.6CYP11B1, CYP11B2
2iron ion bindingGO:0055069.3NOS3, CYP11B1, CYP11B2
3heme bindingGO:0200378.8NOS3, CYP11B1, CYP11B2, CYBB

Products for genes affiliated with Low Renin Hypertension

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Sources for Low Renin Hypertension

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet