MCID: LWR010
MIFTS: 46

Low Renin Hypertension malady

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Summaries for Low Renin Hypertension

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MalaCards based summary: Low Renin Hypertension is related to hyperaldosteronism and glucocorticoid-remediable aldosteronism. An important gene associated with Low Renin Hypertension is CYP11B2 (cytochrome P450, family 11, subfamily B, polypeptide 2), and among its related pathways are superpathway of steroid hormone biosynthesis and Metabolism of steroid hormones and vitamin D. The compounds 18-hydroxycorticosterone and 11b-Hydroxyandrost-4-ene-3,17-dione have been mentioned in the context of this disorder. Affiliated tissues include testes, cortex and adrenal gland, and related mouse phenotypes are renal/urinary system and normal.

Aliases & Classifications for Low Renin Hypertension

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Sources:
46OMIM, 44Novoseek, 62UMLS
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Low Renin Hypertension, Aliases & Descriptions:

Name: Low Renin Hypertension 46 44 62


Related Diseases for Low Renin Hypertension

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Diseases related to Low Renin Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1hyperaldosteronism31.0CYP11B2, CYP11B1, HSD11B2, REN
2glucocorticoid-remediable aldosteronism30.7REN, CYP11B1, CYP11B2
3hypertension30.7CYP11B2, EDN1, CYP11B1, HSD11B2, ADD1, REN
4adenoma30.4CYP11B2, CYP11B1, HSD11B2, REN
5essential hypertension29.5NOS3, REN, ADD1, SOD1, HSD11B2, CYP11B1
6proteinuria29.3EDN1, NOS3, OLR1, CCL2, REN, ADD1
7gitelman syndrome10.5REN
8hypoaldosteronism10.4CYP11B2, REN
9renal hypertension10.4EDN1, REN
10hepatorenal syndrome10.4EDN1, REN
11adrenocortical carcinoma10.3CYP11B2, CYP11B1
12acute chest syndrome10.3NOS3
13blindness10.3
14liddle syndrome10.3CYP11B2, HSD11B2, REN
15hypokalemia10.3CYP11B2, HSD11B2, REN
16conn's syndrome10.3REN, CYP11B1, CYP11B2
17congenital adrenal hyperplasia10.3CYP11B2, CYP11B1, REN
18congestive heart failure10.3EDN1, CYP11B2, REN
19pneumoconiosis10.3SOD1
20prinzmetal's variant angina10.2EDN1, NOS3
21addison's disease10.2REN, CYP11B2
22coronary artery vasospasm10.2NOS3, EDN1
23adrenal cortical adenoma10.2REN, CYP11B1
24hepatopulmonary syndrome10.2NOS3, EDN1
25adrenal adenoma10.2CYP11B2, CYP11B1, HSD11B2, REN
26impotence10.2EDN1, NOS3
27apparent mineralocorticoid excess syndrome10.2
28acromegaly10.2
29nephrosclerosis10.2
30familial hyperaldosteronism10.2
31endotheliitis10.2
32cushing's syndrome10.2CYP11B2, CYP11B1, HSD11B2, REN
33glomerulosclerosis10.2CCL2, REN, EDN1
34primary hyperoxaluria10.2REN, ADD1, EDN1
35interstitial lung disease10.2CCL2, EDN1
36portal hypertension10.2EDN1, NOS3
37renal fibrosis10.2CCL2, REN
38stroke, ischemic10.1EDN1, REN, NOS3
39polycystic kidney disease, autosomal dominant10.1ADD1, REN, NOS3
40hypercholesterolemia10.1EDN1, OLR1, NOS3
41proliferative diabetic retinopathy10.1EDN1, CCL2
42anthracosis10.1SOD1, CCL2
43liver cirrhosis10.0EDN1, HSD11B2, REN, NOS3
44congenital heart disease10.0NOS3, REN, CYP11B2, EDN1
45chronic granulomatous disease10.0SOD1, CYBB
46systemic scleroderma10.0EDN1, CCL2, NOS3
47coronary artery anomaly9.9NOS3, OLR1, ADD1, EDN1
48pulmonary fibrosis9.9EDN1, SOD1, CCL2
49cork-handlers' disease9.8EDN1, SOD1, CCL2
50cerebrovascular disease9.8CYP11B1, ADD1, REN, OLR1, NOS3

Graphical network of the top 20 diseases related to Low Renin Hypertension:



Diseases related to low renin hypertension

Symptoms for Low Renin Hypertension

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Drugs & Therapeutics for Low Renin Hypertension

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Drug clinical trials:

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Search NIH Clinical Center for Low Renin Hypertension

Genetic Tests for Low Renin Hypertension

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Anatomical Context for Low Renin Hypertension

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MalaCards organs/tissues related to Low Renin Hypertension:

32
Testes, Cortex, Adrenal gland, Endothelial, Adrenal cortex

Animal Models for Low Renin Hypertension or affiliated genes

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Publications for Low Renin Hypertension

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Articles related to Low Renin Hypertension:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Myocardial remodeling in low-renin hypertension: molecular pathways to cellular injury in relative aldosteronism. (19895752)
2009
2
Molecular and clinical investigations in patients with low-renin hypertension. (18704622)
2009
3
Letter regarding article by Hood et al, "The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio". (18250276)
2008
4
Low renin hypertension (LRH): shades of John Laragh. (18353670)
2008
5
The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio. (17606839)
2007
6
Monogenic forms of low-renin hypertension. (17066054)
2006
7
Reduced NAD(P)H oxidase in low renin hypertension: link among angiotensin II, atherogenesis, and blood pressure. (16344366)
2006
8
Low-renin hypertension with relative aldosterone excess is associated with impaired NO-mediated vasodilation. (16172426)
2005
9
Effects of eplerenone versus losartan in patients with low-renin hypertension. (16169319)
2005
10
Endogenous ouabain and acute salt loading in low-renin hypertension. (16053985)
2005
11
Endothelin-aldosterone interaction and proteinuria in low-renin hypertension. (15076164)
2004
12
The syndromes of low-renin hypertension: "separating the wheat from the chaff". (15761538)
2004
13
-344C/T polymorphism of CYP11B2 gene in Italian patients with idiopathic low renin hypertension. (11587161)
2001
14
Performance of the basal aldosterone to renin ratio and of the renin stimulation test by furosemide and upright posture in screening for aldosterone-producing adenoma in low renin hypertensives. (11549664)
2001
15
A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22). (11073536)
2000
16
Low renin hypertension in the next millennium. (10651217)
2000
17
T594M mutation in the ENaC beta subunit and low-renin hypertension in blacks. (10469873)
1999
18
A genetic defect resulting in mild low-renin hypertension. (9707624)
1998
19
Artificial mutations in P450c11AS (aldosterone synthase) can increase enzymatic activity: a model for low-renin hypertension? (7883820)
1995
20
Morphology and function of mesenteric resistance arteries in transgenic rats with low-renin hypertension. (1335000)
1992
21
Defects in cortisol metabolism causing low-renin hypertension. (1879383)
1991
22
Increased activity of digoxin-like substance in low-renin hypertension in acromegaly. (2196126)
1990
23
Alterations in aldosterone secretion and metabolism in low renin hypertension. (2229301)
1990
24
Natriuretic hormones in low renin hypertension. (2439743)
1987
25
Dopamine reduces aldosterone and 18-hydroxycorticosterone response to angiotensin II in patients with essential low-renin hypertension and idiopathic hyperaldosteronism. (3882312)
1985
26
Evidence for a circulating endogenous Na+-K+ pump inhibitor in low-renin hypertension. (2411605)
1985
27
Evidence for a circulating sodium-potassium pump inhibitor in low renin hypertension. (3893806)
1985
28
Endogenous sodium-potassium pump inhibitor in low renin hypertension. (3001753)
1985
29
The vascular Na+-K+ pump in low renin hypertension. (6204161)
1984
30
Fatal, low renin hypertension associated with a disturbance of cortisol metabolism. (6362571)
1983
31
Sodium-potassium pump in low-renin hypertension. (6303176)
1983
32
Natriuretic hormone--the missing link in low renin hypertension? (6756413)
1982
33
Role of a humoral sodium-potassium pump inhibitor in experimental low renin hypertension. (6280009)
1982
34
Partial characterization of unusual polar steroids in the urine of a child with low renin hypertension. (6283272)
1982
35
Prorenin measurements and sensitivity to spironolactone: a clinical tool for pathophysiological characterization of low-renin hypertension. (7013758)
1981
36
Studies on the role of a humoral sodium-transport inhibitor and the anteroventral third ventricle (AV3V) in experimental low-renin hypertension. (7032830)
1981
37
Implication of endogenous prostaglandin system in the antihypertensive effect of captopril, SQ 14225, in low renin hypertension. (6993721)
1980
38
Role of prostaglandin in the antihypertensive mechanism of captopril in low renin hypertension. (7004721)
1980
39
Efficacy of captopril in experimental low renin hypertension. (7009165)
1980
40
Is low-renin hypertension an overdiagnosed syndrome? (624453)
1978
41
Low-renin hypertension: classification, mechanisms and therapy. (352521)
1978
42
The characterization of low renin hypertension by plasma renin activity and plasma aldosterone concentration. (750601)
1978
43
Plasma aldosterone response to ACTH in primary aldosteronism and in patients with low renin hypertension. (225341)
1978
44
Low renin hypertension. (891220)
1977
45
Cardiovascular complications in low renin hypertension. (895500)
1977
46
Low renin hypertension--is it a stage of essential hypertension? (867421)
1977
47
Low renin hypertension. (1096763)
1975
48
Body-fluid volume in low-renin hypertension. (4136048)
1974
49
Prognosis in low renin hypertension. (4682227)
1973
50
Low renin hypertension and the adrenal cortex. (4339423)
1972

Variations for Low Renin Hypertension

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Expression for genes affiliated with Low Renin Hypertension

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Expression patterns in normal tissues for genes affiliated with Low Renin Hypertension

Search GEO for disease gene expression data for Low Renin Hypertension.

Pathways for genes affiliated with Low Renin Hypertension

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Pathways related to Low Renin Hypertension according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
estradiol biosynthesis II37
androgen biosynthesis37
estradiol biosynthesis I37
progesterone biosynthesis37
9.9CYP11B1, CYP11B2
2
Show member pathways
9.9CYP11B1, CYP11B2
39.9EDN1, HSD11B2
4
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism37
9.6HSD11B2, CYP11B1, CYP11B2
59.6NOS3, EDN1
6
Show member pathways
9.4GCH1, NOS3
79.3NOS3, CCL2
8
Show member pathways
9.3NOS3, REN, CYP11B2
99.1EDN1, CYBB, NOS3
10
Show member pathways
9.0NOS3, SOD1
11
Show member pathways
9.0NOS3, SOD1

Compounds for genes affiliated with Low Renin Hypertension

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Compounds related to Low Renin Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
118-hydroxycorticosterone44 2411.0CYP11B1, REN, CYP11B2
211b-Hydroxyandrost-4-ene-3,17-dione2410.0HSD11B2, CYP11B2, CYP11B1
311 deoxycortisol4410.0CYP11B2, CYP11B1, REN
4cortisol28 2411.0CYP11B2, CYP11B1, HSD11B2
5hydralazine44 50 1112.0CYP11B2, EDN1, REN
619-Oxo-deoxycorticosterone249.9CYP11B1, CYP11B2
7atenolol44 50 28 24 1113.9EDN1, CYP11B2, REN
8cortisone44 2410.8CYP11B2, HSD11B2, CYP11B1
9metoclopramide44 50 1111.8CYP11B2, CYP11B1, REN
10doca449.8CYP11B2, HSD11B2, CYP11B1, REN
1111beta-hydroxysteroid449.7CYP11B2, HSD11B2, REN, CYP11B1
1217-hydroxyprogesterone44 2410.7REN, CYP11B1, CYP11B2
13valsartan44 61 28 1112.7REN, CCL2, EDN1
14hydrochlorothiazide44 28 50 24 1113.7CYP11B2, REN, ADD1, HSD11B2
15androstenedione44 2410.7REN, HSD11B2, CYP11B2, CYP11B1
16hydrocortisone44 2 61 1112.6HSD11B2, REN, CYP11B1, CYP11B2
17irbesartan44 28 50 1112.6REN, CCL2, CYP11B2, EDN1
18carbenoxolone44 28 1111.5HSD11B2, REN, EDN1
19spironolactone44 61 28 50 1113.4CYP11B1, ADD1, REN, CYP11B2, HSD11B2
20corticosterone44 61 2411.2CYP11B2, CYP11B1, CCL2, REN, HSD11B2
21potassium44 24 1111.2ADD1, CYP11B2, CYP11B1, HSD11B2, REN
22candesartan44 50 28 1112.2REN, CCL2, CYP11B2, NOS3
23losartan44 50 28 1112.2REN, EDN1, OLR1, CCL2, CYP11B2
24adma449.1EDN1, CCL2, OLR1, NOS3
25probucol44 1110.0CCL2, EDN1, SOD1
26sodium44 2410.0HSD11B2, CYP11B1, ADD1, EDN1, REN, CYP11B2
27carvedilol44 50 28 1112.0NOS3, EDN1, REN
28atorvastatin44 50 28 24 1113.0EDN1, CCL2, NOS3, OLR1
29ang ii449.0REN, CCL2, EDN1, NOS3, CYP11B2
30cgmp44 289.9EDN1, NOS3, REN, GCH1
31ng-nitro-l-arginine448.9NOS3, SOD1, EDN1
32nitroglycerin44 119.8SOD1, NOS3, REN, EDN1
33n(g)-nitro-l-arginine methyl ester448.8SOD1, OLR1, EDN1, NOS3
34norepinephrine44 24 1110.8GCH1, CCL2, REN, HSD11B2, CYP11B2, EDN1
35sodium nitroprusside448.8EDN1, NOS3, REN, SOD1
36dexamethasone44 50 28 1111.7CYBB, CYP11B1, CCL2, HSD11B2, REN, CYP11B2
37apocynin44 619.7EDN1, CYBB, SOD1, NOS3
38tetrahydrobiopterin44 24 1110.6GCH1, SOD1, NOS3
39cholesterol44 28 24 1111.5ADD1, CYP11B2, CYP11B1, HSD11B2, REN, CCL2
40diphenyleneiodonium448.5SOD1, CCL2, CYBB, NOS3
41prostacyclin448.3SOD1, REN, CCL2, NOS3, EDN1
428-isoprostane448.2NOS3, CCL2, EDN1, CYBB, SOD1
43indomethacin44 28 61 1111.1NOS3, OLR1, REN, SOD1, CYBB, EDN1
44glucose448.0CYP11B2, HSD11B2, ADD1, CCL2, GCH1, OLR1
45superoxide44 248.7CCL2, CYBB, SOD1, OLR1, NOS3, GCH1
46nadph44 248.5OLR1, SOD1, CYBB, HSD11B2, CCL2, GCH1
47calcium44 50 24 1110.4EDN1, REN, NOS3, HSD11B2, GCH1, CCL2
48oxygen44 247.6NOS3, GCH1, OLR1, CCL2, SOD1, HSD11B2
49nitric oxide44 24 118.6SOD1, EDN1, CYBB, CYP11B2, NOS3, ADD1
50arginine446.3CYP11B1, OLR1, CCL2, REN, SOD1, HSD11B2

GO Terms for genes affiliated with Low Renin Hypertension

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Cellular components related to Low Renin Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.7CCL2, SOD1, CYBB
2extracellular regionGO:0055767.9OLR1, CCL2, REN, SOD1, EDN1

Biological processes related to Low Renin Hypertension according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood volume by renal aldosteroneGO:00201710.3CYP11B2, HSD11B2
2cortisol biosynthetic processGO:03465110.3CYP11B2, CYP11B1
3aldosterone biosynthetic processGO:03234210.3CYP11B2, CYP11B1
4mineralocorticoid biosynthetic processGO:00670510.3CYP11B2, CYP11B1
5cellular response to potassium ionGO:03586510.3CYP11B1, CYP11B2
6C21-steroid hormone biosynthetic processGO:00670010.2CYP11B2, CYP11B1
7glucocorticoid biosynthetic processGO:00670410.2HSD11B2, CYP11B1
8sterol metabolic processGO:01612510.2CYP11B1, CYP11B2
9cellular response to hormone stimulusGO:03287010.0CYP11B1, CYP11B2
10maternal process involved in parturitionGO:06013710.0EDN1, CCL2
11regulation of systemic arterial blood pressure by endothelinGO:0031009.9EDN1, NOS3
12response to amino acidGO:0432009.9CCL2, EDN1
13response to lipopolysaccharideGO:0324969.8GCH1, REN, EDN1
14cellular response to interleukin-1GO:0713479.7EDN1, CCL2
15nitric oxide biosynthetic processGO:0068099.7GCH1, NOS3
16nitric oxide metabolic processGO:0462099.7NOS3, GCH1
17response to hypoxiaGO:0016669.6EDN1, HSD11B2, CCL2
18regulation of nitric-oxide synthase activityGO:0509999.6NOS3, GCH1
19negative regulation of blood pressureGO:0457769.6GCH1, NOS3
20hydrogen peroxide biosynthetic processGO:0506659.6SOD1, CYBB
21neutrophil chemotaxisGO:0305939.6CCL2, EDN1
22superoxide metabolic processGO:0068019.5SOD1, CYBB
23lipopolysaccharide-mediated signaling pathwayGO:0316639.5NOS3, CCL2
24interaction with hostGO:0517019.4NOS3, CYBB
25phagosome maturationGO:0903829.4NOS3, CYBB
26superoxide anion generationGO:0425549.3SOD1, CYBB, EDN1
27in utero embryonic developmentGO:0017019.3NOS3, ADD1, EDN1
28response to hydrogen peroxideGO:0425429.0OLR1, SOD1
29response to heatGO:0094088.9NOS3, CCL2, SOD1
30response to drugGO:0424938.8CYBB, HSD11B2, SOD1, CCL2
31regulation of blood pressureGO:0082178.4NOS3, GCH1, REN, SOD1, CYP11B1

Molecular functions related to Low Renin Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid 11-beta-monooxygenase activityGO:0045079.6CYP11B1, CYP11B2
2iron ion bindingGO:0055069.3NOS3, CYP11B1, CYP11B2
3heme bindingGO:0200378.8NOS3, CYP11B1, CYP11B2, CYBB

Products for genes affiliated with Low Renin Hypertension

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Sources for Low Renin Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet