MCID: LWR010
MIFTS: 34

Low Renin Hypertension malady

Summaries for Low Renin Hypertension

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MalaCards: Low Renin Hypertension is related to hypertension and hyperaldosteronism. An important gene associated with Low Renin Hypertension is CYP11B2 (cytochrome P450, family 11, subfamily B, polypeptide 2), and among its related pathways are Endogenous sterols and Mineralocorticoid biosynthesis. The compounds hydralazine and norepinephrine have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and immune system.

Aliases & Classifications for Low Renin Hypertension

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46OMIM, 44Novoseek, 60UMLS
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Aliases & Descriptions:

low renin hypertension 46 44 60


Related Diseases for Low Renin Hypertension

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17GeneCards, 18GeneDecks
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Diseases related to Low Renin Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.6OLR1, REN, CYP11B2, CYP11B1, NR3C2, EDN1
2hyperaldosteronism30.6CYP11B2, CYP11B1, NR3C2, NPPA, HSD11B2, REN
3essential hypertension30.6SOD1, NPPA, EDN1, NR3C2, HSD11B2, CYP11B1
4renal hypertension30.4REN, ACE, EDN1
5acromegaly30.2HSD11B2
6apparent mineralocorticoid excess syndrome30.2HSD11B2, NR3C2
7nephrosclerosis30.2ACE, NR3C2
8glucocorticoid-remediable aldosteronism30.2CYP11B2, NR3C2, CYP11B1, REN
9adenoma30.2REN, CYP11B2, CYP11B1, NR3C2, HSD11B2
10proteinuria30.1HSD11B2, CCL2, EDN1, NR3C2, ADD1, ACE
11ovarian hyperstimulation syndrome10.0REN
12polycystic ovary syndrome10.0NR3C2
13coronary stenosis10.0OLR1
14bipolar disorder10.0GCH1
15cerebral palsy10.0GCH1
16hypoaldosteronism10.0REN, CYP11B2
17glaucoma10.0HSD11B2, EDN1
18anuria10.0ACE
19cerebrovascular disease10.0ACE
20thromboembolism10.0NOS3
21oligohydramnios10.0ACE
22glomerulonephritis10.0CCL2
23parkinson's disease10.0GCH1
24wilms tumor10.0REN
25mitral valve disease10.0NPPA
26rheumatoid arthritis10.0CCL2
27peritonitis10.0CCL2
28atopy10.0NOS3
29arthritis10.0CCL2
30fibromuscular dysplasia10.0REN
31interstitial lung disease10.0CCL2
32pneumonia10.0CCL2
33cor pulmonale10.0NPPA, EDN1
34addison's disease10.0REN, CYP11B2
35lupus nephritis10.0CCL2
36breast cancer10.0NR3C2, HSD11B2
37deficiency anemia10.0ACE
38kawasaki disease10.0CCL2
39hepatopulmonary syndrome10.0EDN1, NOS3
40pseudohypoaldosteronism type ii10.0NR3C2, REN
41leukemia10.0NR3C2, CYBB
42endometriosis10.0CCL2
43graves' disease10.0NOS3
44vasculitis10.0CCL2
45congenital adrenal hyperplasia10.0CYP11B1, CYP11B2, REN
46adrenocortical carcinoma10.0HSD11B2, CYP11B1, CYP11B2
47intracranial aneurysm10.0NOS3
48renal tubular dysgenesis10.0REN, ACE
49cushing's syndrome10.0NR3C2, HSD11B2
50pheochromocytoma10.0GCH1, NPPA

Graphical network of the top 20 diseases related to Low Renin Hypertension:



Diseases related to low renin hypertension

Clinical Features for Low Renin Hypertension

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Drugs & Therapeutics for Low Renin Hypertension

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Low Renin Hypertension

Genetic Tests for Low Renin Hypertension

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Anatomical Context for Low Renin Hypertension

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Animal Models for Low Renin Hypertension or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Low Renin Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.0HSD11B2, NPPA, EDN1, NR3C2, CYP11B1, CYP11B2
2MP:00053876.9SOD1, CYP11B1, CYBB, REN, OLR1, NOS3
3MP:00036316.9CCL2, SOD1, EDN1, NR3C2, CYP11B1, CYBB
4MP:00053696.7HSD11B2, CCL2, SOD1, NPPA, EDN1, NR3C2
5MP:00053866.6HSD11B2, CCL2, SOD1, NR3C2, CYP11B2, CYBB
6MP:00053976.6CCL2, SOD1, NPPA, NR3C2, CYP11B1, REN
7MP:00107686.2HSD11B2, CCL2, SOD1, EDN1, NR3C2, CYP11B2
8MP:00053855.6ACE, HSD11B2, CCL2, SOD1, NPPA, EDN1
9MP:00053765.3NR3C2, EDN1, NPPA, SOD1, CCL2, HSD11B2

Publications for Low Renin Hypertension

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Genetic Variations for Low Renin Hypertension

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Expression for genes affiliated with Low Renin Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Low Renin Hypertension

Search GEO for disease gene expression data for Low Renin Hypertension.

Pathways for genes affiliated with Low Renin Hypertension

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB
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Compounds for genes affiliated with Low Renin Hypertension

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Low Renin Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 184)
idCompoundScoreTop Affiliating Genes
1hydralazine44 49 1112.5CYP11B2
2norepinephrine44 11 2412.0GCH1, NR3C2, CYP11B2
3captopril44 28 49 59 1114.0EDN1, NR3C2, REN
4tetrahydroaldosterone449.8CYP11B2, REN, NR3C2
5toki-shakuyaku-san449.8EDN1, REN, NPPA
6cortisol28 2410.8HSD11B2, CYP11B2, NR3C2, CYP11B1
711 deoxycortisol449.7NR3C2, CYP11B1, REN, CYP11B2
8fludrocortisone44 28 1111.6NPPA, CYP11B2, REN, NR3C2
9doca449.6REN, CYP11B2, CYP11B1, NR3C2, HSD11B2
10metoclopramide44 1110.6NPPA, REN, CYP11B1, CYP11B2
1111beta-hydroxysteroid449.5CYP11B2, REN, CYP11B1, NR3C2, HSD11B2
12cilazapril44 1110.4EDN1, NPPA, ACE
13nadph44 2410.3NR3C2, CYBB, OLR1, HSD11B2, GCH1
14cortisone44 2410.3CYP11B2, CYP11B1, NR3C2, HSD11B2
15adma449.2OLR1, EDN1, CCL2, NOS3
16ibopamine449.2NPPA, REN, ACE
17eplerenone44 59 28 1112.2CYP11B2, ACE, REN, NR3C2
18trandolapril44 1110.2NPPA, ACE, EDN1, REN
19omapatrilat449.1NPPA, EDN1, REN, ACE
20losartan44 49 28 1112.1REN, CYP11B2, NR3C2, EDN1, NPPA, OLR1
21enalaprilat449.1ACE, REN, EDN1, NPPA
22quinapril44 1110.1NPPA, EDN1, REN, ACE
23corticosterone44 59 2411.0REN, CYP11B2, NR3C2, CYP11B1, CCL2, HSD11B2
24thiazide449.0REN, ADD1, NR3C2, ACE
25acth449.0CYP11B2, NR3C2, NPPA, CYP11B1, REN, HSD11B2
26valsartan44 59 28 1111.9REN, CCL2, EDN1, ACE
27n(g)-nitro-l-arginine methyl ester448.9NOS3, OLR1, SOD1, EDN1
28isosorbide dinitrate44 49 1110.9EDN1, ACE, NOS3, NPPA
29furosemide44 49 59 28 11 2413.9ADD1, ACE, NPPA, HSD11B2, REN
30metoprolol44 28 49 11 2412.8NOS3, ACE, REN, NPPA
31hydrochlorothiazide44 49 28 11 2412.7CYP11B2, HSD11B2, REN, NR3C2, ACE, ADD1
328-isoprostane448.7CCL2, SOD1, NOS3, CYBB, EDN1
33carvedilol44 49 28 1111.7ACE, NOS3, REN, EDN1, NPPA
34irbesartan44 28 49 1111.7CCL2, CYP11B2, REN, ACE
35perindopril44 49 1110.7REN, ACE, NPPA, NOS3
36oxygen44 249.7HSD11B2, OLR1, CYBB, CYP11B2, CYP11B1, NR3C2
37felodipine44 28 1110.6ACE, REN, NR3C2, NPPA
38ng-nitro-l-arginine448.4SOD1, NOS3, EDN1, NPPA
39nitroglycerin44 119.1SOD1, NPPA, REN, NOS3, EDN1, ACE
40spironolactone49 44 59 28 1112.1ADD1, NR3C2, NPPA, HSD11B2, ACE, REN
41potassium44 11 2410.0CYP11B1, CYP11B2, HSD11B2, NPPA, NR3C2, ADD1
42sodium44 248.8NPPA, EDN1, NR3C2, HSD11B2, CYP11B1, CYP11B2
43ang ii447.6ACE, NOS3, REN, CYP11B2, NR3C2, EDN1
44cholesterol44 28 11 2410.6ACE, HSD11B2, NR3C2, CCL2, ADD1, CYP11B1
45prostacyclin447.6NOS3, CCL2, SOD1, REN, NPPA, ACE
46creatinine447.4CCL2, HSD11B2, NPPA, REN, NR3C2, SOD1
47glucose447.2OLR1, ACE, REN, CYBB, CYP11B2, NR3C2
48calcium44 49 11 249.4ADD1, EDN1, NR3C2, CYP11B1, CYP11B2, NOS3
49arginine446.4HSD11B2, GCH1, CCL2, SOD1, NPPA, EDN1
50nitric oxide44 11 247.8ADD1, ACE, NOS3, GCH1, SOD1, NPPA

GO Terms for genes affiliated with Low Renin Hypertension

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16Gene Ontology
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Cellular components related to Low Renin Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.3ACE, REN, EDN1, NPPA, SOD1, CCL2
2extracellular regionGO:0055767.3SOD1, NPPA, EDN1, REN, OLR1, ACE

Biological processes related to Low Renin Hypertension according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood volume by renal aldosteroneGO:00201710.3CYP11B2, HSD11B2
2cortisol biosynthetic processGO:03465110.3CYP11B1, CYP11B2
3aldosterone biosynthetic processGO:03234210.3CYP11B1, CYP11B2
4cellular response to potassium ionGO:03586510.3CYP11B1, CYP11B2
5mineralocorticoid biosynthetic processGO:00670510.3CYP11B1, CYP11B2
6C21-steroid hormone biosynthetic processGO:00670010.2CYP11B2, CYP11B1
7glucocorticoid biosynthetic processGO:00670410.2HSD11B2, CYP11B1
8regulation of systemic arterial blood pressure by endothelinGO:00310010.0EDN1, NOS3
9sterol metabolic processGO:01612510.0CYP11B2, CYP11B1
10maternal process involved in parturitionGO:06013710.0CCL2, EDN1
11nitric oxide biosynthetic processGO:0068099.8NOS3, GCH1
12hydrogen peroxide biosynthetic processGO:0506659.8SOD1, CYBB
13regulation of blood vessel sizeGO:0508809.7NPPA, NOS3
14response to lipopolysaccharideGO:0324969.7REN, EDN1, GCH1
15nitric oxide metabolic processGO:0462099.7NOS3, GCH1
16superoxide anion generationGO:0425549.6SOD1, EDN1, CYBB
17angiotensin maturationGO:0020039.6ACE, REN
18superoxide metabolic processGO:0068019.5SOD1, CYBB
19response to heatGO:0094089.2NOS3, SOD1, CCL2
20regulation of vasoconstrictionGO:0192299.1ACE, EDN1
21regulation of blood pressureGO:0082177.7ACE, NOS3, REN, CYP11B1, NPPA, SOD1

Molecular functions related to Low Renin Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid 11-beta-monooxygenase activityGO:0045079.7CYP11B2, CYP11B1
2heme bindingGO:0200379.2NOS3, CYBB, CYP11B2, CYP11B1

Products for genes affiliated with Low Renin Hypertension

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Sources for Low Renin Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet