MCID: LRR001
MIFTS: 29

Lrrk2-Related Parkinson Disease malady

Genetic diseases, Rare diseases, Neuronal diseases, Metabolic diseases, Cancer diseases, Cardiovascular diseases, Mental diseases categories

Aliases & Classifications for Lrrk2-Related Parkinson Disease

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Lrrk2-Related Parkinson Disease, Aliases & Descriptions:

Name: Lrrk2-Related Parkinson Disease 19 20
Lrrk2-Associated Parkinson Disease 19
 
Parkinson Disease 8 60
Park8 19


Classifications:



Summaries for Lrrk2-Related Parkinson Disease

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MalaCards based summary: Lrrk2-Related Parkinson Disease, also known as lrrk2-associated parkinson disease, is related to parkinson disease, late-onset and supranuclear palsy, progressive. An important gene associated with Lrrk2-Related Parkinson Disease is LRRK2 (leucine-rich repeat kinase 2), and among its related pathways are Integrated Pancreatic Cancer Pathway and Parkinsons Disease Pathway. The compounds trifluoroethanol and colchicine have been mentioned in the context of this disorder. Related mouse phenotypes are behavior/neurological and hematopoietic system.

GeneReviews summary for lrrk2

Related Diseases for Lrrk2-Related Parkinson Disease

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Diseases in the Secondary Parkinson Disease family:

Parkinson Disease 7, Autosomal Recessive Early-Onset Parkinson Disease 19, Juvenile-Onset
Parkinson Disease 10 Parkinson Disease, Late-Onset
Parkinson Disease 16 Parkinson Disease 18
Parkinson Disease 17 Parkinson Disease 20, Early-Onset
Parkinson Disease 12 Parkinson Disease 13
Parkinson Disease 11 Parkinson Disease 5
Parkinson Disease 4 Parkinson Disease 1
Parkinson Disease 8 Parkinson Disease 15, Autosomal Recessive
Parkinson Disease 14 Parkinson Disease 6, Early Onset
Parkinson Disease, Juvenile, Type 2 lrrk2-related parkinson disease
Parkinson Disease Type 3 Parkinson Disease Type 9
Park7-Related Parkinson Disease Snca-Related Parkinson Disease
Htra2-Related Parkinson Disease Vps35-Related Parkinson Disease
Fbxo7-Related Parkinson Disease

Diseases related to Lrrk2-Related Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson disease, late-onset30.0ADH1C, MAPT, TBP
2supranuclear palsy, progressive10.1MAPT, LRRK2
3tauopathy10.1LRRK2, MAPT
4movement disease10.1MAPT, LRRK2
5hydrocephalus10.1GBA, MAPT
6breast cancer10.1
7multiple system atrophy10.1MAPT, LRRK2
8dementia, frontotemporal10.0MAPT, LRRK2
9spinocerebellar ataxia10.0MAPT, TBP
10alcohol dependence10.0NR4A2, ADH1C, MAPT
11herpes simplex10.0GBA, TBP
12huntington disease9.8TBP, MAPT
13parkinson disease type 39.8SNCAIP, LRRK2, MAPT
14dementia, lewy body9.8MAPT, SNCAIP, LRRK2
15ipex syndrome9.7MAPT, GBA, TBP
16alzheimer disease9.3MAPT, TBP, NR4A2, SNCAIP, LRRK2
17dementia9.3MAPT, TBP, LRRK2, GBA, SNCAIP

Graphical network of diseases related to Lrrk2-Related Parkinson Disease:



Diseases related to lrrk2-related parkinson disease

Symptoms for Lrrk2-Related Parkinson Disease

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Drugs & Therapeutics for Lrrk2-Related Parkinson Disease

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Drug clinical trials:

Search ClinicalTrials for Lrrk2-Related Parkinson Disease

Search NIH Clinical Center for Lrrk2-Related Parkinson Disease

Genetic Tests for Lrrk2-Related Parkinson Disease

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Genetic tests related to Lrrk2-Related Parkinson Disease:

id Genetic test Affiliating Genes
1 Lrrk2-Related Parkinson Disease20 LRRK2

Anatomical Context for Lrrk2-Related Parkinson Disease

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Animal Models for Lrrk2-Related Parkinson Disease or affiliated genes

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MGI Mouse Phenotypes related to Lrrk2-Related Parkinson Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.6NR4A2, MAPT, LRRK2, GBA
2MP:00053978.3GBA, LRRK2, MAPT, NR4A2
3MP:00053768.0GBA, LRRK2, ADH1C, NR4A2, TBP
4MP:00053787.9GBA, ADH1C, MAPT, NR4A2, TBP
5MP:00107687.6TBP, NR4A2, MAPT, ADH1C, LRRK2, GBA

Publications for Lrrk2-Related Parkinson Disease

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Articles related to Lrrk2-Related Parkinson Disease:

idTitleAuthorsYear
1
Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease. (25401511)
2014
2
LRRK2-Related Parkinson Disease (20301387)
1993

Variations for Lrrk2-Related Parkinson Disease

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Expression for genes affiliated with Lrrk2-Related Parkinson Disease

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Search GEO for disease gene expression data for Lrrk2-Related Parkinson Disease.

Pathways for genes affiliated with Lrrk2-Related Parkinson Disease

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Compounds for genes affiliated with Lrrk2-Related Parkinson Disease

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Compounds related to Lrrk2-Related Parkinson Disease according to GeneCards Suite gene sharing:

(show all 17)
idCompoundScoreTop Affiliating Genes
1trifluoroethanol43 1210.8MAPT, ADH1C
2colchicine43 59 2 28 1213.6GBA, MAPT
3tmao439.6TBP, MAPT
4phosphocellulose439.6TBP, MAPT
5choline43 24 1211.5MAPT, ADH1C
6sodium dodecylsulfate439.5MAPT, TBP
7cyclophosphamide43 49 1211.4MAPT, ADH1C
8formaldehyde43 2410.2ADH1C, MAPT, TBP
9glycerol43 24 1211.2ADH1C, MAPT, TBP
10steroid439.1TBP, NR4A2, GBA
11proline439.0GBA, MAPT, TBP
12zinc43 2410.0TBP, MAPT, ADH1C
13cysteine438.8TBP, MAPT, GBA
14dopamine43 28 24 1211.6NR4A2, MAPT, SNCAIP, LRRK2
15retinoic acid43 249.6MAPT, NR4A2, TBP
16serine438.6TBP, NR4A2, MAPT, GBA
17alanine438.6SNCAIP, MAPT, TBP

GO Terms for genes affiliated with Lrrk2-Related Parkinson Disease

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Cellular components related to Lrrk2-Related Parkinson Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304249.6MAPT, LRRK2

Biological processes related to Lrrk2-Related Parkinson Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription initiation from RNA polymerase II promoterGO:00063679.4TBP, NR4A2
2neuron migrationGO:00017649.2NR4A2, MAPT
3cell deathGO:00082198.4TBP, SNCAIP, GBA

Molecular functions related to Lrrk2-Related Parkinson Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055157.2TBP, NR4A2, MAPT, SNCAIP, LRRK2, GBA

Products for genes affiliated with Lrrk2-Related Parkinson Disease

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  • Antibodies
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Lrrk2-Related Parkinson Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet