PARK8
MCID: LRR001
MIFTS: 24

Lrrk2-Related Parkinson Disease (PARK8) malady

Summaries for Lrrk2-Related Parkinson Disease

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19GeneReviews, 32MalaCards
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MalaCards: Lrrk2-Related Parkinson Disease, also known as lrrk2-associated parkinson disease, is related to parkinson's disease and parkinson disease 8. An important gene associated with Lrrk2-Related Parkinson Disease is LRRK2 (leucine-rich repeat kinase 2), and among its related pathways are Parkinsons Disease Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The compounds trifluoroethanol and tmao have been mentioned in the context of this disorder. Related mouse phenotypes are growth/size and mortality/aging.

GeneReviews summary for lrrk2

Aliases & Classifications for Lrrk2-Related Parkinson Disease

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19GeneReviews, 20GeneTests, 60UMLS
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Aliases & Descriptions:

lrrk2-related parkinson disease 19 20
lrrk2-associated parkinson disease 19
parkinson disease, late-onset 60
parkinson disease 8 60
park8 19


Related Diseases for Lrrk2-Related Parkinson Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Parkinson's Disease family:

lrrk2-related parkinson disease Parkinson Disease Type 3
Parkinson Disease Type 9 Park7-Related Parkinson Disease
Snca-Related Parkinson Disease Htra2-Related Parkinson Disease
Vps35-Related Parkinson Disease Fbxo7-Related Parkinson Disease
Parkinson Disease 6, Early Onset Parkinson Disease 19, Juvenile-Onset
Parkinson Disease 10 Parkinson Disease, Late-Onset
Parkinson Disease 16 Parkinson Disease 13
Parkinson Disease 11 Parkinson Disease 18
Parkinson Disease 5 Parkinson Disease 4
Parkinson Disease 1 Parkinson Disease, Juvenile, Type 2
Parkinson Disease 8 Parkinson Disease 17
Parkinson Disease 20, Early-Onset Parkinson Disease 14
Parkinson Disease 12

Diseases related to Lrrk2-Related Parkinson Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 24)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease30.4SNCAIP, NR4A2, MAPT, GBA, LRRK2
2parkinson disease 810.2
3wolff-parkinson-white syndrome10.2
4parkinson disease type 910.2
5prolidase deficiency10.2
6autosomal dominant disease10.0
7chromosomal disease10.0
8parkinson disease, late-onset10.0
9essential tremor10.0LRRK2
10aphasia10.0MAPT
11pick's disease10.0MAPT
12multiple system atrophy10.0MAPT, LRRK2
13progressive supranuclear palsy10.0MAPT, LRRK2
14tauopathy10.0MAPT, LRRK2
15movement disease10.0MAPT, LRRK2
16spinocerebellar ataxia10.0MAPT, TBP
17frontotemporal dementia10.0MAPT, LRRK2
18hydrocephalus10.0GBA, MAPT
19huntington's disease10.0TBP, MAPT
20parkinson disease type 310.0SNCAIP, MAPT, LRRK2
21lewy body dementia10.0LRRK2, SNCAIP, MAPT
22ipex syndrome10.0TBP, GBA, MAPT
23alzheimer's disease10.0NR4A2, MAPT, LRRK2, SNCAIP, TBP
24dementia10.0SNCAIP, TBP, MAPT, GBA, LRRK2

Graphical network of the top 20 diseases related to Lrrk2-Related Parkinson Disease:



Diseases related to lrrk2-related parkinson disease

Clinical Features for Lrrk2-Related Parkinson Disease

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Drugs & Therapeutics for Lrrk2-Related Parkinson Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Lrrk2-Related Parkinson Disease

Drug clinical trials:

Search ClinicalTrials for Lrrk2-Related Parkinson Disease

Search NIH Clinical Center for Lrrk2-Related Parkinson Disease

Search CenterWatch for Lrrk2-Related Parkinson Disease

Genetic Tests for Lrrk2-Related Parkinson Disease

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20GeneTests
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Genetic tests related to Lrrk2-Related Parkinson Disease:

id Genetic test Affiliating Genes
1 Lrrk2-Related Parkinson Disease20 LRRK2

Anatomical Context for Lrrk2-Related Parkinson Disease

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Animal Models for Lrrk2-Related Parkinson Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lrrk2-Related Parkinson Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.9NR4A2, TBP, MAPT, GBA, ADH1C
2MP:00107687.3NR4A2, TBP, MAPT, GBA, LRRK2, ADH1C

Publications for Lrrk2-Related Parkinson Disease

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50PubMed
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Articles related to Lrrk2-Related Parkinson Disease:

idTitleAuthorsYear
1
LRRK2-Related Parkinson Disease (20301387)
1993

Genetic Variations for Lrrk2-Related Parkinson Disease

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Expression for genes affiliated with Lrrk2-Related Parkinson Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lrrk2-Related Parkinson Disease

Search GEO for disease gene expression data for Lrrk2-Related Parkinson Disease.

Pathways for genes affiliated with Lrrk2-Related Parkinson Disease

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Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG
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Pathways related to Lrrk2-Related Parkinson Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3LRRK2, SNCAIP
2
Hide members
8.1LRRK2, MAPT, TBP, SNCAIP

Compounds for genes affiliated with Lrrk2-Related Parkinson Disease

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 2BitterDB, 28IUPHAR, 24HMDB
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Compounds related to Lrrk2-Related Parkinson Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1trifluoroethanol44 1110.6ADH1C, MAPT
2tmao449.6MAPT, TBP
3phosphocellulose449.5TBP, MAPT
4colchicine59 44 2 28 1113.3MAPT, GBA
5sodium dodecylsulfate449.3MAPT, TBP
6formaldehyde44 2410.0ADH1C, MAPT, TBP
7glycerol44 11 2411.0TBP, MAPT, ADH1C
8proline448.8GBA, MAPT, TBP
9dopamine44 28 11 2411.5LRRK2, MAPT, NR4A2, SNCAIP
10serine448.1GBA, MAPT, TBP, NR4A2

GO Terms for genes affiliated with Lrrk2-Related Parkinson Disease

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Sources:
16Gene Ontology
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Biological processes related to Lrrk2-Related Parkinson Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron migrationGO:0017649.5MAPT, NR4A2
2cell deathGO:0082198.2GBA, TBP, SNCAIP

Products for genes affiliated with Lrrk2-Related Parkinson Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lrrk2-Related Parkinson Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet