PARK8
MCID: LRR001
MIFTS: 25

Lrrk2-Related Parkinson Disease (PARK8) malady

Summaries for Lrrk2-Related Parkinson Disease

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19GeneReviews, 33MalaCards
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MalaCards: Lrrk2-Related Parkinson Disease, also known as lrrk2-associated parkinson disease, is related to parkinson's disease and parkinson disease 8. An important gene associated with Lrrk2-Related Parkinson Disease is LRRK2 (leucine-rich repeat kinase 2), and among its related pathways are Parkinsons Disease Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The compounds trifluoroethanol and tmao have been mentioned in the context of this disorder. Related mouse phenotypes are growth/size and mortality/aging.

GeneReviews summary for lrrk2

Aliases & Classifications for Lrrk2-Related Parkinson Disease

Sources:
19GeneReviews, 20GeneTests, 61UMLS
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Aliases & Descriptions:

lrrk2-related parkinson disease 19 20
lrrk2-associated parkinson disease 19
parkinson disease, late-onset 61
parkinson disease 8 61
park8 19


Related Diseases for Lrrk2-Related Parkinson Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lrrk2-Related Parkinson Disease:



Diseases related to lrrk2-related parkinson disease

Clinical Features for Lrrk2-Related Parkinson Disease

Drugs & Therapeutics for Lrrk2-Related Parkinson Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Lrrk2-Related Parkinson Disease

Search CenterWatch for Lrrk2-Related Parkinson Disease

Genetic Tests for Lrrk2-Related Parkinson Disease

Sources:
20GeneTests
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Genetic tests related to Lrrk2-Related Parkinson Disease:

id Genetic test Affiliating Genes
1 Lrrk2-related Parkinson Disease20 LRRK2

Anatomical Context for Lrrk2-Related Parkinson Disease

Animal Models for Lrrk2-Related Parkinson Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Lrrk2-Related Parkinson Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.9ADH1C, GBA, MAPT, TBP, NR4A2
2MP:00107687.3ADH1C, NR4A2, TBP, MAPT, GBA, LRRK2

Publications for Lrrk2-Related Parkinson Disease

Sources:
51PubMed
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Articles related to Lrrk2-Related Parkinson Disease:

(show all 11)
idTitleAuthorsYear
1
Prevalence of cancer in Parkinson's disease related to R1441G and G2019S mutations in LRRK2. (24357540)
2013
2
Olfactory deficits and cardiac 123I-MIBG in Parkinson's disease related to the LRRK2 R1441G and G2019S mutations. (21611983)
2011
3
Genomewide linkage study of modifiers of LRRK2-related Parkinson's disease. (21661047)
2011
4
MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. (20067578)
2010
5
Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans. (20197411)
2010
6
Penetrance in Parkinson's disease related to the LRRK2 R1441G mutation in the Basque country (Spain). (20721916)
2010
7
Lrrk2 R1441G-related Parkinson's disease: evidence of a common founding event in the seventh century in Northern Spain. (19308469)
2009
8
Metabolomic profiling in LRRK2-related Parkinson's disease. (19847307)
2009
9
The small GTPase activity of the ROC domain from LRRK2, a Parkinson's disease related protein. (20001906)
2009
10
Is the common LRRK2 G2019S mutation related to dyskinesias in North African Parkinson disease? (18981379)
2008
11
LRRK2-Related Parkinson Disease (20301387)
1993

Genetic Variations for Lrrk2-Related Parkinson Disease

Expression for genes affiliated with Lrrk2-Related Parkinson Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lrrk2-Related Parkinson Disease

Search GEO for disease gene expression data for Lrrk2-Related Parkinson Disease.

Pathways for genes affiliated with Lrrk2-Related Parkinson Disease

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG
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Pathways related to Lrrk2-Related Parkinson Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3LRRK2, SNCAIP
2
Hide members
8.1LRRK2, MAPT, TBP, SNCAIP

Compounds for genes affiliated with Lrrk2-Related Parkinson Disease

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 2BitterDB, 29IUPHAR, 24HMDB
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Compounds related to Lrrk2-Related Parkinson Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1trifluoroethanol45 1110.6ADH1C, MAPT
2tmao459.6MAPT, TBP
3phosphocellulose459.5TBP, MAPT
4colchicine60 45 2 29 1113.3MAPT, GBA
5sodium dodecylsulfate459.3MAPT, TBP
6formaldehyde45 2410.0ADH1C, MAPT, TBP
7glycerol45 11 2411.0TBP, MAPT, ADH1C
8proline458.8GBA, MAPT, TBP
9dopamine45 29 11 2411.5LRRK2, MAPT, NR4A2, SNCAIP
10serine458.1GBA, MAPT, TBP, NR4A2

GO Terms for genes affiliated with Lrrk2-Related Parkinson Disease

Sources:
16Gene Ontology
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Biological processes related to Lrrk2-Related Parkinson Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron migrationGO:0017649.5MAPT, NR4A2
2cell deathGO:0082198.2GBA, TBP, SNCAIP

Products for genes affiliated with Lrrk2-Related Parkinson Disease

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  • Antibodies

Sources for Lrrk2-Related Parkinson Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet