PARK8
MCID: LRR001
MIFTS: 34

Lrrk2-Related Parkinson Disease (PARK8) malady

Genetic diseases, Rare diseases, Neuronal diseases, Eye diseases, Metabolic diseases, Mental diseases categories

Summaries for Lrrk2-Related Parkinson Disease

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MalaCards based summary: Lrrk2-Related Parkinson Disease, also known as lrrk2-associated parkinson disease, is related to parkinson's disease and progressive supranuclear palsy. An important gene associated with Lrrk2-Related Parkinson Disease is LRRK2 (leucine-rich repeat kinase 2), and among its related pathways are Integrated Pancreatic Cancer Pathway and Parkinsons Disease Pathway. The compounds trifluoroethanol and colchicine have been mentioned in the context of this disorder. Related mouse phenotypes are behavior/neurological and hematopoietic system.

GeneReviews summary for lrrk2

Aliases & Classifications for Lrrk2-Related Parkinson Disease

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Lrrk2-Related Parkinson Disease, Aliases & Descriptions:

Name: Lrrk2-Related Parkinson Disease 20 21
Lrrk2-Associated Parkinson Disease 20
 
Parkinson Disease 8 61
Park8 20


Classifications:



Related Diseases for Lrrk2-Related Parkinson Disease

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Diseases in the Parkinson's Disease family:

lrrk2-related parkinson disease Autosomal Recessive Juvenile Parkinson Disease
Parkinson Disease Type 3 Parkinson Disease Type 9
Park7-Related Parkinson Disease Snca-Related Parkinson Disease
Htra2-Related Parkinson Disease Vps35-Related Parkinson Disease
Fbxo7-Related Parkinson Disease Parkinson Disease 7, Autosomal Recessive Early-Onset
Parkinson Disease 6, Early Onset Parkinson Disease 19, Juvenile-Onset
Parkinson Disease 10 Parkinson Disease, Late-Onset
Parkinson Disease 16 Parkinson Disease 13
Parkinson Disease 11 Parkinson Disease 18
Parkinson Disease 5 Parkinson Disease 4
Parkinson Disease 1 Parkinson Disease, Juvenile, Type 2
Parkinson Disease 8 Parkinson Disease 17
Parkinson Disease 20, Early-Onset Parkinson Disease 15, Autosomal Recessive
Parkinson Disease 14 Parkinson Disease 12
Hereditary Parkinson Disease with Late-Onset

Diseases related to Lrrk2-Related Parkinson Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease30.6ADH1C, MAPT, TBP
2progressive supranuclear palsy10.1MAPT, LRRK2
3tauopathy10.1MAPT, LRRK2
4movement disease10.1MAPT, LRRK2
5hydrocephalus10.1GBA, MAPT
6multiple system atrophy10.1MAPT, LRRK2
7breast cancer10.1
8parkinson disease, late-onset10.1
9frontotemporal dementia10.0LRRK2, MAPT
10spinocerebellar ataxia10.0TBP, MAPT
11herpes simplex10.0TBP, GBA
12huntington's disease9.8MAPT, TBP
13parkinson disease type 39.8MAPT, SNCAIP, LRRK2
14lewy body dementia9.8MAPT, SNCAIP, LRRK2
15ipex syndrome9.7TBP, MAPT, GBA
16alzheimer's disease9.3LRRK2, SNCAIP, MAPT, NR4A2, TBP
17dementia9.3GBA, LRRK2, SNCAIP, MAPT, TBP

Graphical network of diseases related to Lrrk2-Related Parkinson Disease:



Diseases related to lrrk2-related parkinson disease

Symptoms for Lrrk2-Related Parkinson Disease

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Drugs & Therapeutics for Lrrk2-Related Parkinson Disease

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Drug clinical trials:

Search ClinicalTrials for Lrrk2-Related Parkinson Disease

Search NIH Clinical Center for Lrrk2-Related Parkinson Disease

Genetic Tests for Lrrk2-Related Parkinson Disease

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Genetic tests related to Lrrk2-Related Parkinson Disease:

id Genetic test Affiliating Genes
1 Lrrk2-Related Parkinson Disease21 LRRK2

Anatomical Context for Lrrk2-Related Parkinson Disease

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Animal Models for Lrrk2-Related Parkinson Disease or affiliated genes

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MGI Mouse Phenotypes related to Lrrk2-Related Parkinson Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.6NR4A2, MAPT, LRRK2, GBA
2MP:00053978.3GBA, LRRK2, MAPT, NR4A2
3MP:00053768.0GBA, LRRK2, ADH1C, NR4A2, TBP
4MP:00053787.9GBA, ADH1C, MAPT, NR4A2, TBP
5MP:00107687.6TBP, NR4A2, MAPT, ADH1C, LRRK2, GBA

Publications for Lrrk2-Related Parkinson Disease

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Articles related to Lrrk2-Related Parkinson Disease:

idTitleAuthorsYear
1
Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease. (25401511)
2014
2
LRRK2-Related Parkinson Disease (20301387)
1993

Variations for Lrrk2-Related Parkinson Disease

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Expression for genes affiliated with Lrrk2-Related Parkinson Disease

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Expression patterns in normal tissues for genes affiliated with Lrrk2-Related Parkinson Disease

Search GEO for disease gene expression data for Lrrk2-Related Parkinson Disease.

Pathways for genes affiliated with Lrrk2-Related Parkinson Disease

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Compounds for genes affiliated with Lrrk2-Related Parkinson Disease

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Compounds related to Lrrk2-Related Parkinson Disease according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1trifluoroethanol44 1210.8MAPT, ADH1C
2colchicine44 60 3 29 1213.6GBA, MAPT
3tmao449.6TBP, MAPT
4phosphocellulose449.6TBP, MAPT
5choline44 25 1211.5MAPT, ADH1C
6sodium dodecylsulfate449.5MAPT, TBP
7cyclophosphamide44 50 1211.4MAPT, ADH1C
8formaldehyde44 2510.2ADH1C, MAPT, TBP
9glycerol44 25 1211.2ADH1C, MAPT, TBP
10steroid449.1TBP, NR4A2, GBA
11proline449.0GBA, MAPT, TBP
12zinc44 2510.0TBP, MAPT, ADH1C
13cysteine448.8TBP, MAPT, GBA
14dopamine44 29 25 1211.6NR4A2, MAPT, SNCAIP, LRRK2
15retinoic acid44 259.6MAPT, NR4A2, TBP
16serine448.6TBP, NR4A2, MAPT, GBA
17alanine448.6SNCAIP, MAPT, TBP

GO Terms for genes affiliated with Lrrk2-Related Parkinson Disease

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Cellular components related to Lrrk2-Related Parkinson Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.6MAPT, LRRK2

Biological processes related to Lrrk2-Related Parkinson Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription initiation from RNA polymerase II promoterGO:0063679.4TBP, NR4A2
2neuron migrationGO:0017649.2NR4A2, MAPT
3cell deathGO:0082198.4TBP, SNCAIP, GBA

Molecular functions related to Lrrk2-Related Parkinson Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.2TBP, NR4A2, MAPT, SNCAIP, LRRK2, GBA

Products for genes affiliated with Lrrk2-Related Parkinson Disease

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Sources for Lrrk2-Related Parkinson Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet