MCID: LCY001
MIFTS: 22

Lucey-Driscoll Syndrome malady

Genetic diseases category

Summaries for Lucey-Driscoll Syndrome

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Lucey-driscoll syndrome, a form of transient familial hyperbilirubinemia, is a rare metabolic disorder that leads to very high levels of bilirubin in a newborn's blood. babies with this disorder may be born with severe jaundice (yellow skin), yellow eyes and lethargy. it occurs when the body does not properly break down (metabolize) a certain form of bilirubin.  if untreated, this condition can cause seizures, neurologic problems (kernicterus) and even death. treatment for lucey-driscoll syndrome includes phototherapy with blue light (to treat the high level of bilirubin in the blood) and an exchange transfusion is sometimes necessary. different inheritance patterns have been reported and in some cases, it occurs in individuals with no family history of the condition. last updated: 11/15/2010

MalaCards: Lucey-Driscoll Syndrome, also known as transient familial neonatal hyperbilirubinemia, is related to gilbert syndrome and hyperbilirubinemia, familial transcient neonatal. An important gene associated with Lucey-Driscoll Syndrome is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1). The compounds scopoletin and chrysin have been mentioned in the context of this disorder. Affiliated tissues include eye and skin.

Aliases & Classifications for Lucey-Driscoll Syndrome

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42NIH Rare Diseases, 22GTR, 60UMLS, 20GeneTests
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases


Aliases & Descriptions:

lucey-driscoll syndrome 42 22 60
transient familial neonatal hyperbilirubinemia 42 20
transient familial hyperbilirubinemia 42


Related Diseases for Lucey-Driscoll Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Lucey-Driscoll Syndrome:



Diseases related to lucey-driscoll syndrome

Clinical Features for Lucey-Driscoll Syndrome

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Drugs & Therapeutics for Lucey-Driscoll Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Lucey-Driscoll Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Lucey-Driscoll Syndrome:

id Genetic test Affiliating Genes
1 Transient Familial Neonatal Hyperbilirubinemia20 UGT1A1
2 Lucey-Driscoll Syndrome22

Anatomical Context for Lucey-Driscoll Syndrome

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32MalaCards
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MalaCards organs/tissues related to Lucey-Driscoll Syndrome:

32
Eye, Skin

Animal Models for Lucey-Driscoll Syndrome or affiliated genes

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Publications for Lucey-Driscoll Syndrome

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Genetic Variations for Lucey-Driscoll Syndrome

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Expression for genes affiliated with Lucey-Driscoll Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lucey-Driscoll Syndrome

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Pathways for genes affiliated with Lucey-Driscoll Syndrome

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Compounds for genes affiliated with Lucey-Driscoll Syndrome

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Lucey-Driscoll Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1scopoletin449.6UGT1A, UGT1A1
2chrysin449.6UGT1A1, UGT1A
3morphine 6-glucuronide449.6UGT1A1, UGT1A
4morphine-3-glucuronide449.6UGT1A1, UGT1A
5sn38 glucuronide449.6UGT1A1, UGT1A
61-naphthol449.6UGT1A1, UGT1A
74-methylumbelliferone449.6UGT1A1, UGT1A
8atazanavir44 49 1111.6UGT1A1, UGT1A
9n-hydroxy phip449.6UGT1A1, UGT1A
10udp glucuronic acid449.6UGT1A1, UGT1A
11lamotrigine44 1110.6UGT1A1, UGT1A
12glucuronide449.6UGT1A, UGT1A1
13benzidine449.6UGT1A1, UGT1A
14flunitrazepam44 28 1111.5UGT1A, UGT1A1
15naproxen44 11 2411.5UGT1A1, UGT1A
16apigenin44 2810.5UGT1A1, UGT1A
17flurbiprofen44 28 49 1112.5UGT1A1, UGT1A
18phip449.5UGT1A1, UGT1A
19buprenorphine44 28 1111.5UGT1A1, UGT1A
20cotinine44 2410.5UGT1A, UGT1A1
21flavonoid449.5UGT1A, UGT1A1
22sn 3844 5910.5UGT1A1, UGT1A
23mycophenolic acid44 49 1111.5UGT1A, UGT1A1
24hydrocarbons449.5UGT1A, UGT1A1
25beta-naphthoflavone44 1110.5UGT1A, UGT1A1
26glucuronic acid449.5UGT1A, UGT1A1
27p-nitrophenol44 1110.5UGT1A1, UGT1A
28saquinavir44 1110.5UGT1A1, UGT1A
29uridine diphosphate449.5UGT1A, UGT1A1
30indinavir44 49 1111.5UGT1A1, UGT1A
31trifluoperazine44 28 1111.5UGT1A1, UGT1A
32udpglucose449.5UGT1A, UGT1A1
33phenol44 2410.5UGT1A, UGT1A1
34androstane449.4UGT1A, UGT1A1
35propofol44 49 1111.4UGT1A, UGT1A1
36tcdd449.4UGT1A1, UGT1A
37sulforaphane449.4UGT1A, UGT1A1
38mycophenolate mofetil44 49 1111.4UGT1A, UGT1A1
39ketoconazole44 28 11 2412.4UGT1A, UGT1A1
40phenytoin44 49 28 1112.4UGT1A, UGT1A1
41epoxide449.4UGT1A1, UGT1A
42benzo(a)pyrene449.3UGT1A, UGT1A1
43diclofenac44 28 49 1112.3UGT1A1, UGT1A
44rifampicin44 28 5911.3UGT1A1, UGT1A
45imipramine44 49 28 11 2413.2UGT1A1, UGT1A
46uridine44 11 2411.2UGT1A, UGT1A1
47irinotecan44 49 1111.1UGT1A1, UGT1A
48amine449.1UGT1A, UGT1A1
49acetaminophen44 2 49 11 2413.0UGT1A1, UGT1A
50phenobarbital44 28 1110.8UGT1A, UGT1A1

GO Terms for genes affiliated with Lucey-Driscoll Syndrome

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Products for genes affiliated with Lucey-Driscoll Syndrome

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  • Antibodies
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Sources for Lucey-Driscoll Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet