MCID: LCY001
MIFTS: 18

Lucey-Driscoll Syndrome malady

Genetic category

Summaries for Lucey-Driscoll Syndrome

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Lucey-driscoll syndrome, a form of transient familial hyperbilirubinemia, is a rare metabolic disorder that leads to very high levels of bilirubin in a newborn's blood. babies with this disorder may be born with severe jaundice (yellow skin), yellow eyes and lethargy. it occurs when the body does not properly break down (metabolize) a certain form of bilirubin.  if untreated, this condition can cause seizures, neurologic problems (kernicterus) and even death. treatment for lucey-driscoll syndrome includes phototherapy with blue light (to treat the high level of bilirubin in the blood) and an exchange transfusion is sometimes necessary. different inheritance patterns have been reported and in some cases, it occurs in individuals with no family history of the condition. last updated: 11/15/2010

MalaCards: Lucey-Driscoll Syndrome, also known as transient familial neonatal hyperbilirubinemia, is related to gilbert syndrome and hyperbilirubinemia, familial transcient neonatal. An important gene associated with Lucey-Driscoll Syndrome is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1). The compounds scopoletin and chrysin have been mentioned in the context of this disorder. Affiliated tissues include skin.

Aliases & Classifications for Lucey-Driscoll Syndrome

Sources:
43NIH Rare Diseases, 20GeneTests, 22GTR, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic


Aliases & Descriptions:

lucey-driscoll syndrome 43 22 61
transient familial neonatal hyperbilirubinemia 43 20
transient familial hyperbilirubinemia 43


Related Diseases for Lucey-Driscoll Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Lucey-Driscoll Syndrome:



Diseases related to lucey-driscoll syndrome

Clinical Features for Lucey-Driscoll Syndrome

Drugs & Therapeutics for Lucey-Driscoll Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Lucey-Driscoll Syndrome

Drug clinical trials:

Search ClinicalTrials for Lucey-Driscoll Syndrome

Search NIH Clinical Center for Lucey-Driscoll Syndrome

Search CenterWatch for Lucey-Driscoll Syndrome

Genetic Tests for Lucey-Driscoll Syndrome

Sources:
20GeneTests, 22GTR
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Genetic tests related to Lucey-Driscoll Syndrome:

id Genetic test Affiliating Genes
1 Transient Familial Neonatal Hyperbilirubinemia20 UGT1A1
2 Lucey-driscoll Syndrome22

Anatomical Context for Lucey-Driscoll Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Lucey-Driscoll Syndrome:

33
Skin

Animal Models for Lucey-Driscoll Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Lucey-Driscoll Syndrome

Genetic Variations for Lucey-Driscoll Syndrome

Expression for genes affiliated with Lucey-Driscoll Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lucey-Driscoll Syndrome

Search GEO for disease gene expression data for Lucey-Driscoll Syndrome.

Pathways for genes affiliated with Lucey-Driscoll Syndrome

Compounds for genes affiliated with Lucey-Driscoll Syndrome

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Lucey-Driscoll Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1scopoletin459.6UGT1A, UGT1A1
2chrysin459.6UGT1A1, UGT1A
3morphine 6-glucuronide459.6UGT1A1, UGT1A
4morphine-3-glucuronide459.6UGT1A1, UGT1A
5sn38 glucuronide459.6UGT1A1, UGT1A
61-naphthol459.6UGT1A1, UGT1A
74-methylumbelliferone459.6UGT1A1, UGT1A
8atazanavir45 50 1111.6UGT1A1, UGT1A
9n-hydroxy phip459.6UGT1A1, UGT1A
10udp glucuronic acid459.6UGT1A1, UGT1A
11lamotrigine45 1110.6UGT1A1, UGT1A
12glucuronide459.6UGT1A, UGT1A1
13benzidine459.6UGT1A1, UGT1A
14flunitrazepam45 29 1111.5UGT1A, UGT1A1
15naproxen45 11 2411.5UGT1A1, UGT1A
16apigenin45 2910.5UGT1A1, UGT1A
17flurbiprofen45 29 50 1112.5UGT1A1, UGT1A
18phip459.5UGT1A1, UGT1A
19buprenorphine45 29 1111.5UGT1A1, UGT1A
20cotinine45 2410.5UGT1A, UGT1A1
21flavonoid459.5UGT1A, UGT1A1
22sn 3845 6010.5UGT1A1, UGT1A
23mycophenolic acid45 50 1111.5UGT1A, UGT1A1
24hydrocarbons459.5UGT1A, UGT1A1
25beta-naphthoflavone45 1110.5UGT1A, UGT1A1
26glucuronic acid459.5UGT1A, UGT1A1
27p-nitrophenol45 1110.5UGT1A1, UGT1A
28saquinavir45 1110.5UGT1A1, UGT1A
29uridine diphosphate459.5UGT1A, UGT1A1
30indinavir45 50 1111.5UGT1A1, UGT1A
31trifluoperazine45 29 1111.5UGT1A1, UGT1A
32udpglucose459.5UGT1A, UGT1A1
33phenol45 2410.5UGT1A, UGT1A1
34androstane459.4UGT1A, UGT1A1
35propofol45 50 1111.4UGT1A, UGT1A1
36tcdd459.4UGT1A1, UGT1A
37sulforaphane459.4UGT1A, UGT1A1
38mycophenolate mofetil45 50 1111.4UGT1A, UGT1A1
39ketoconazole45 29 11 2412.4UGT1A, UGT1A1
40phenytoin45 50 29 1112.4UGT1A, UGT1A1
41epoxide459.4UGT1A1, UGT1A
42benzo(a)pyrene459.3UGT1A, UGT1A1
43diclofenac45 29 50 1112.3UGT1A1, UGT1A
44rifampicin45 29 6011.3UGT1A1, UGT1A
45imipramine45 50 29 11 2413.2UGT1A1, UGT1A
46uridine45 11 2411.2UGT1A, UGT1A1
47irinotecan45 50 1111.1UGT1A1, UGT1A
48amine459.1UGT1A, UGT1A1
49acetaminophen45 2 50 11 2413.0UGT1A1, UGT1A
50phenobarbital45 29 1110.8UGT1A, UGT1A1

GO Terms for genes affiliated with Lucey-Driscoll Syndrome

Products for genes affiliated with Lucey-Driscoll Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lucey-Driscoll Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet