MCID: LMB052
MIFTS: 46

Lumbar Disc Herniation malady

Summaries for Lumbar Disc Herniation

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 A Spinal disc herniation (prolapsus disci intervertebralis) is a medical condition affecting the spine... more...

MalaCards: Lumbar Disc Herniation is related to degenerative disc disease and spondylitis. An important gene associated with Lumbar Disc Herniation is COL11A1 (collagen, type XI, alpha 1), and among its related pathways are Interleukin-1 processing and Cell adhesion Cell-matrix glycoconjugates. The compounds procollagen and alginate have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and t cells, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Description from OMIM:47 603932

Aliases & Classifications for Lumbar Disc Herniation

Sources:
47OMIM
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Aliases & Descriptions:

lumbar disc herniation 47


Related Diseases for Lumbar Disc Herniation

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lumbar Disc Herniation:



Diseases related to lumbar disc herniation

Clinical Features for Lumbar Disc Herniation

Sources:
47OMIM
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Clinical features from OMIM:

603932

Drugs & Therapeutics for Lumbar Disc Herniation

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Lumbar Disc Herniation

Drug clinical trials:

Search ClinicalTrials for Lumbar Disc Herniation

Search NIH Clinical Center for Lumbar Disc Herniation

Search CenterWatch for Lumbar Disc Herniation

Genetic Tests for Lumbar Disc Herniation

Anatomical Context for Lumbar Disc Herniation

Sources:
33MalaCards
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MalaCards organs/tissues related to Lumbar Disc Herniation:

33
Skin, Spinal cord, T cells, B cells, Dorsal root ganglion

Animal Models for Lumbar Disc Herniation or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Lumbar Disc Herniation

Sources:
51PubMed
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Articles related to Lumbar Disc Herniation:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Randomized, double-blind, placebo-controlled, trial of transforaminal epidural etanercept for the treatment of symptomatic lumbar disc herniation. (24165696)
2013
2
Percutaneous endoscopic interlaminar discectomy for pediatric lumbar disc herniation. (24301611)
2013
3
Letter to editor concerning: "Intradural lumbar disc herniation: report of five cases with literature review". (23443678)
2013
4
Influence of the deqi sensation by suspended moxibustion stimulation in lumbar disc herniation: study for a multicenter prospective two arms cohort study. (23956778)
2013
5
Interference of detection rate of lumbar disc herniation by socioeconomic status. (23508288)
2013
6
Does opioid pain medication use affect the outcome of patients with lumbar disc herniation? (23591657)
2013
7
ISSLS Prize winner: The anatomy of failure in lumbar disc herniation: an in vivo, multimodal, prospective study of 181 subjects. (23680832)
2013
8
The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after lumbar disc herniation. (22337560)
2012
9
Pregnancy and childbirth after microsurgery for lumbar disc herniation. (22037981)
2012
10
Clinical efficacy of three different minimally invasive procedures for far lateral lumbar disc herniation. (22613535)
2012
11
Can clinical and radiological findings predict surgery for lumbar disc herniation? A systematic literature review. (23236305)
2012
12
Bilateral lumbar disc herniation at the same discal level: a new radiological appearance. (23053287)
2012
13
Lumbar disc herniation in the Spine Patient Outcomes Research Trial: does educational attainment impact outcome? (21311402)
2011
14
Posterior ring apophysis separation combined with lumbar disc herniation in adults: a 10-year experience in the surgical management of 87 cases. (21294611)
2011
15
A very rare cause of low-back pain and sciatica: deep vein thrombosis due to absence of the inferior vena cava mimicking the clinical and radiological signs of lumbar disc herniation. (21529127)
2011
16
Transcript levels of major MMPs and ADAMTS-4 in relation to the clinicopathological profile of patients with lumbar disc herniation. (20857147)
2011
17
Bilateral acute foot drop following lumbar disc herniation--a case report. (22666944)
2011
18
A study of the relationship between type of lumbar disc herniation, straight leg raising test and peripheral T lymphocytes. (22009908)
2010
19
Role of trait anxiety in persistent radicular pain after surgery for lumbar disc herniation: a 1-year longitudinal study. (20644411)
2010
20
Evaluation of the effectiveness of lumbar interlaminar epidural injections in managing chronic pain of lumbar disc herniation or radiculitis: a randomized, double-blind, controlled trial. (20648203)
2010
21
Radicular interdural lumbar disc herniation. (19888608)
2010
22
Pre-operative blood test for antibody to nucleus pulposus may distinguish types of lumbar disc herniation. (20466491)
2010
23
Association of the tag SNPs in the human SKT gene (KIAA1217) with lumbar disc herniation. (19338451)
2009
24
Comparison of the analgesic effect of ibuprofen with mesalamine after discectomy surgery in patients with lumbar disc herniation: a double-blind randomized controlled trial. (19587472)
2009
25
Transforaminal percutaneous endoscopic lumbar discectomy for upper lumbar disc herniation: clinical outcome, prognostic factors, and technical consideration. (19229467)
2009
26
Do corticosteroids produce additional benefit in nerve root infiltration for lumbar disc herniation? (18379400)
2008
27
Patients' satisfaction with provided care/information and expectations on clinical outcome after lumbar disc herniation surgery. (17224823)
2007
28
Outcome of revision discectomies following recurrent lumbar disc herniation. (16741457)
2006
29
Indication of posterior lumbar interbody fusion for lumbar disc herniation. (16760783)
2006
30
Ochronosis and lumbar disc herniation. (16736091)
2006
31
Interrelationships among pain, disability, and psychological factors in young Korean conscripts with lumbar disc herniation. (17153552)
2006
32
Posterior endoscopic surgery for lumbar disc herniation with contralateral symptoms - a report of two cases. (17163341)
2006
33
Adolescent lumbar disc herniation and hamstring tightness: review of 16 cases. (16845356)
2006
34
Microendoscopic discectomy for lumbar disc herniation: surgical technique and outcome in 873 consecutive cases. (17077737)
2006
35
Scrotal pain as the presenting symptom of lumbar disc herniation: a report of 2 cases. (15644747)
2005
36
Concomitant sacroiliac joint pain in patients with lumbar disc herniation: case series. (15691185)
2004
37
Efficacy of serotonin receptor blocker for symptomatic lumbar disc herniation. (12782871)
2003
38
Lumbar disc herniation in early childhood: case report and literature review. (12715195)
2003
39
Evaluation of myelography and computed tomography in clinically diagnosed patients of lumbar disc herniation. (15168973)
2003
40
Quantifying the stress induced by distress in patients with lumbar disc herniation in terms of natural killer cell activity measurements: chromium release assay versus multiparameter flow cytometric assay. (12394920)
2002
41
The role of cyclooxygenase-2 in lumbar disc herniation. (12435978)
2002
42
Intradural lumbar disc herniation: report of two cases. (11339469)
2001
43
Chemonucleolysis of lumbar disc herniation with ethanol. (11924136)
2001
44
Recovery of function in adjacent nerve roots after surgery for lumbar disc herniation: use of quantitative sensory testing in the exploration of different populations of nerve fibers. (11052353)
2000
45
Histochemistry and morphology of the multifidus muscle in lumbar disc herniation: comparative study between diseased and normal sides. (10973402)
2000
46
Contralateral recurrent lumbar disc herniation. Results of discectomy compared with those in primary herniation. (10222532)
1999
47
Intraradicular lumbar disc herniation: case report and review of the literature. (9696104)
1998
48
The involvement of matrix metalloproteinases and inflammation in lumbar disc herniation. (9580952)
1998
49
Prevention of local scar formation after operative discectomy for lumbar disc herniation. (9522901)
1998
50
Contrast-enhanced magnetic resonance imaging in conservative management of lumbar disc herniation. (9460155)
1998

Genetic Variations for Lumbar Disc Herniation

Expression for genes affiliated with Lumbar Disc Herniation

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lumbar Disc Herniation

Search GEO for disease gene expression data for Lumbar Disc Herniation.

Pathways for genes affiliated with Lumbar Disc Herniation

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 4Cell Signaling Technology, 30KEGG, 52QIAGEN
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Pathways related to Lumbar Disc Herniation according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL1A, IL1B
2
Cell adhesion Cell-matrix glycoconjugates
Hide members
9.8ACAN, MMP9, MMP3
3
Hide members
9.8MMP2, MMP3, MMP13
49.7MMP9, MMP2, MMP13
5
Hide members
9.6COL11A1, MMP13, MMP3, MMP2
69.5MMP2, MMP9, PTGS2
79.4IL1B, IL1A, HLA-DRB1
89.4IL1B, IL1A, HLA-DRB1
99.4IL1A, IL1B, MMP9, ACAN
10
Hide members
9.3COL11A1, MMP13, MMP3, MMP2, MMP9
11
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9.3MMP13, MMP3, MMP2, MMP9, THBS2
129.3MMP13, MMP9, ACAN, ADAMTS4
139.2IL1B, MMP3, MMP9, PTGS2
149.1HLA-DQB1, HLA-DRB1, IL1A, IL1B
15
Hide members
9.1IL1B, IL1A, HLA-DRB1, HLA-DQB1
16
Hide members
9.1IL1B, IL1A, HLA-DRB1, HLA-DQB1
17
Hide members
9.0TNFSF18, TNFRSF18, IL1A, IL1B
18
Hide members
8.9HLA-DQB1, HLA-DRB1, IL1A, PTGS2
19
Hide members
8.8COL11A1, F8, MMP13, MMP3, MMP2, MMP9
20
Cell adhesion ECM remodeling
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8.7ADAMTS4, ACAN, MMP9, MMP2, MMP3, MMP13
21
Hide members
8.3HLA-DQB1, HLA-DRB1, MMP13, MMP3, MMP2, MMP9

Compounds for genes affiliated with Lumbar Disc Herniation

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 2BitterDB
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Compounds related to Lumbar Disc Herniation according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1procollagen4510.7ACAN
2alginate4510.5ACAN, MMP13
3(4-aminophenyl)mercuric acetate4510.5MMP3, MMP13
4ivig4510.3IL1A, F8
5doxycycline45 1111.3MMP13, MMP3
6glutamate4510.3OPRM1, COMT
7norepinephrine45 11 2412.2OPRM1, F8
8prostaglandin4510.0IL1B, IL1A, MMP3
9ilomastat4510.0MMP2, MMP9, MMP3
10latanoprost45 1111.0MMP2, MMP3, MMP9
11aprotinin45 1110.9MMP13, MMP2
12gm 6001609.9MMP13, MMP2, MMP3, MMP9
13uk 383367609.9MMP9, MMP13, MMP3, MMP2
14gi 254023x609.9MMP13, MMP9, MMP3, MMP2
15hydroxamate459.9MMP3, MMP2, MMP9, MMP13
16marimastat45 60 1111.9MMP9, MMP2, MMP3, MMP13
17glucosamine45 11 2411.8MMP13, ADAMTS4, ACAN
18batimastat45 60 1111.8MMP2, MMP13, MMP3, MMP9
19epinephrine45 11 2411.7IL1A, COMT, F8, OPRM1
20gold sodium thiomalate459.6IL1B, IL1A, HLA-DRB1
21ndga459.6IL1B, MMP13, MMP3, PTGS2
22piroxicam45 1110.6PTGS2, MMP3, IL1B
23rantes459.6IL1A, IL1B
24aacocf3459.5PTGS2, IL1A, IL1B
25ciglitazone45 2910.5IL1B, MMP9, PTGS2, MMP2
26sulfasalazine45 29 50 1112.5IL1A, IL1B, PTGS2, MMP3
27ibuprofen45 29 50 11 2413.4PTGS2, MMP2, MMP3, IL1B
28tetracycline45 1110.4MMP9, IL1A, MMP13, MMP2
29celecoxib45 60 29 50 11 2414.3IL1B, MMP2, MMP3, MMP9, PTGS2
30ascorbic acid45 2410.3COMT, MMP13, MMP3, MMP2, ACAN, IL1A
31chondroitin sulfate45 2410.3ADAMTS4, ACAN, MMP3, MMP13
32ns 39845 6010.3IL1B, IL1A, PTGS2, MMP9, MMP2
33troglitazone45 29 60 1112.3MMP9, MMP3, IL1B, MMP2, PTGS2
34nicotine45 50 29 1112.3MMP2, MMP9, OPRM1, COMT, IL1A
35pdtc459.2IL1A, IL1B, MMP2, MMP9, PTGS2
36ribonucleic acid459.2MMP13, MMP3, IL1B, IL1A, MMP9, MMP2
37pge2459.2ACAN, ADAMTS4, MMP2, PTGS2, MMP9
38glycosaminoglycan459.1MMP13, MMP3, MMP9, ACAN, ADAMTS4, IL1A
39dexamethasone45 50 29 1112.1ACAN, PTGS2, MMP13, F8, OPRM1, MMP9
40methotrexate45 50 1111.1HLA-DRB1, MMP9, MMP2, MMP3, IL1B
41hyaluronic acid45 2410.1ACAN, MMP9, MMP2, MMP3, MMP13, IL1B
42herbimycin a45 6010.0MMP9, MMP2, MMP13, IL1B, IL1A, PTGS2
43pd 98,059458.9MMP2, MMP9, ACAN, PTGS2, MMP13, IL1B
44curcumin458.8PTGS2, MMP2, MMP3, MMP13, IL1A, MMP9
45retinoic acid45 249.7IL1A, MMP9, MMP2, ACAN, MMP3, COMT
46cysteine458.6THBS2, MMP9, MMP2, MMP13, OPRM1, MMP3
47sb 20358045 609.6PTGS2, ACAN, MMP9, MMP2, MMP3, MMP13
48genistein45 29 60 2 11 2413.6MMP2, MMP9, MMP13, IL1B, IL1A, COMT
49tgf beta1458.5F8, IL1B, MMP13, MMP3, MMP2, MMP9
50vegf458.4MMP3, THBS2, PTGS2, MMP2, MMP13, IL1B

GO Terms for genes affiliated with Lumbar Disc Herniation

Sources:
16Gene Ontology
See all sources

Cellular components related to Lumbar Disc Herniation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055788.7MMP3, MMP2, MMP9, ACAN, ADAMTS4, MMP13
2extracellular spaceGO:0056157.6TNFSF18, F8, IL1A, IL1B, MMP13, MMP3
3extracellular regionGO:0055767.3ACAN, COL11A1, TNFRSF18, F8, IL1A, IL1B

Biological processes related to Lumbar Disc Herniation according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00166010.0IL1B, IL1A
2positive regulation of interleukin-2 biosynthetic processGO:0450869.9IL1B, IL1A
3positive regulation of fever generationGO:0316229.8PTGS2, IL1B
4immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.7HLA-DQB1, HLA-DRB1
5positive regulation vascular endothelial growth factor productionGO:0105759.6PTGS2, IL1B, IL1A
6collagen catabolic processGO:0305749.6MMP9, MMP2, MMP3, MMP13, COL11A1
7extracellular matrix disassemblyGO:0226179.6COL11A1, MMP13, MMP3, MMP2, MMP9
8positive regulation of nitric oxide biosynthetic processGO:0454299.5OPRM1, IL1B, PTGS2
9humoral immune response mediated by circulating immunoglobulinGO:0024559.4HLA-DRB1, HLA-DQB1
10embryo implantationGO:0075669.4IL1B, MMP2, MMP9, PTGS2
11extracellular matrix organizationGO:0301989.3COL11A1, MMP13, MMP3, MMP2, MMP9, ACAN
12cytokine-mediated signaling pathwayGO:0192219.0IL1B, IL1A, HLA-DRB1, HLA-DQB1
13proteolysisGO:0065088.9MMP13, MMP3, MMP2, MMP9, ACAN, ADAMTS4

Molecular functions related to Lumbar Disc Herniation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.7HLA-DRB1, HLA-DQB1
2metalloendopeptidase activityGO:0042228.7ADAMTS4, MMP9, MMP2, MMP3, MMP13

Products for genes affiliated with Lumbar Disc Herniation

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Sources for Lumbar Disc Herniation

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet