MCID: LMB052
MIFTS: 42

Lumbar Disc Herniation malady

Genetic diseases (common) category

Summaries for Lumbar Disc Herniation

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Spinal disc herniation (in Latin prolapsus disci intervertebralis, commonly called a slipped disc) is a... more...

MalaCards: Lumbar Disc Herniation is related to degenerative disc disease and spondylitis. An important gene associated with Lumbar Disc Herniation is COL11A1 (collagen, type XI, alpha 1), and among its related pathways are Protein digestion and absorption and G protein signaling Ras family GTPases in kinase cascades scheme . The compounds (4-aminophenyl)mercuric acetate and thermolysin have been mentioned in the context of this disorder. Affiliated tissues include testes, dorsal root ganglion and skin, and related mouse phenotypes are limbs/digits/tail and homeostasis/metabolism.

Description from OMIM:48 603932

Aliases & Classifications for Lumbar Disc Herniation

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48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

lumbar disc herniation 48


Related Diseases for Lumbar Disc Herniation

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18GeneCards, 19GeneDecks
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Diseases related to Lumbar Disc Herniation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1degenerative disc disease30.5COL9A2
2spondylitis30.5ACAN
3arthritis30.4ACAN, MMP3
4rheumatoid arthritis30.3COL9A2, ACAN, MMP3, MMP13
5cauda equina syndrome10.9
6back pain10.8
7radiculopathy10.7
8blindness10.7
9spinal stenosis10.7
10alkaptonuria10.5
11chronic pain10.5
12cervicitis10.4
13hemangioma10.4
14obesity10.4
15ankylosing spondylitis10.3
16cystic fibrosis10.3
17discitis10.3
18spondylosis10.3
19neuronitis10.3
20spondylolysis10.3
21arachnoiditis10.3
22intracranial hypotension10.3
23ochronosis10.3
24aortic aneurysm10.3
25capillary hemangioma10.3
26chondroma10.3
27hypertension10.3
28hemophilia10.3
29acquired hemophilia10.3
30meralgia paresthetica10.3
31aneurysm10.3
32foot drop10.3
33stickler syndrome10.0COL11A1, COL9A2
34osteochondritis dissecans10.0COL9A2, ACAN
35multiple epiphyseal dysplasia10.0ACAN, COL9A2
36pseudoachondroplasia10.0ACAN, COL9A2
37skeletal dysplasias10.0MMP13, ACAN
38abdominal aortic aneurysm10.0MMP3, MMP13
39periodontitis10.0MMP3, MMP13
40periodontal disease10.0MMP13, MMP3
41basal cell carcinoma10.0MMP3, MMP13
42cataract10.0COL11A1, MMP3
43synovitis10.0ACAN, MMP3, MMP13
44chondrosarcoma10.0ACAN, MMP3, MMP13
45colorectal cancer9.9COL11A1, MMP13, THBS2
46arthropathy9.9HGD, ACAN, MMP3, MMP13
47osteoarthritis9.9MMP13, MMP3, ACAN, COL9A2
48breast cancer9.9THBS2, MMP13, MMP3
49tongue squamous cell carcinoma9.9THBS2, MMP13, MMP3, COL11A1
50colon cancer9.9THBS2, MMP13, MMP3

Graphical network of the top 20 diseases related to Lumbar Disc Herniation:



Diseases related to lumbar disc herniation

Symptoms for Lumbar Disc Herniation

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48OMIM
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Clinical features from OMIM:

603932

Drugs & Therapeutics for Lumbar Disc Herniation

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Lumbar Disc Herniation

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Anatomical Context for Lumbar Disc Herniation

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34MalaCards
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MalaCards organs/tissues related to Lumbar Disc Herniation:

34
Testes, Dorsal root ganglion, Skin

Animal Models for Lumbar Disc Herniation or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Lumbar Disc Herniation:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.2THBS2, MMP13, ACAN, COL11A1
2MP:00053767.6HGD, ACAN, MMP3, MMP13, THBS2
3MP:00053877.6THBS2, MMP3, ACAN, COL11A1, HGD
4MP:00053907.3HGD, COL11A1, ACAN, MMP3, MMP13, THBS2

Publications for Lumbar Disc Herniation

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53PubMed
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Articles related to Lumbar Disc Herniation:

(show top 50)    (show all 499)
idTitleAuthorsYear
1
Trend of the incidence of lumbar disc herniation: decreasing with aging in the elderly. (23966775)
2013
2
Minimally invasive transmuscular approach for the treatment of lumbar herniated disc: far lateral lumbar disc herniation: a clinical study. Applications for cervical and thoracic disc herniation. (23676861)
2013
3
Recurrent lumbar disc herniation: A prospective comparative study of three surgical management procedures. (24403956)
2013
4
The Spine Patient Outcomes Research Trial (SPORT): a continuing return on investment: commentary on an article by Jeffrey A. Rihn, MD, et al.: "The influence of obesity on the outcome of treatment of lumbar disc herniation. analysis of the Spine Patient Outcomes Research Trial (SPORT)". (23192422)
2013
5
Adolescent lumbar disc herniation: experience from a large minimally invasive treatment centre for lumbar degenerative disease in Chongqing, China. (23419406)
2013
6
Percutaneous Endoscopic Lumbar Discectomy and Annuloplasty for Lumbar Disc Herniation at the Low Two Contiguous Levels: Single-Portal, Double Surgeries. (23765920)
2013
7
The influence of obesity on the outcome of treatment of lumbar disc herniation: analysis of the Spine Patient Outcomes Research Trial (SPORT). (23192403)
2013
8
Spinal epidural arteriovenous hemangioma mimicking lumbar disc herniation. (23133733)
2012
9
Lumbar disc herniation in a patient of alkaptonuria: case report and review of literature. (23287346)
2012
10
Pain intensity the first year after lumbar disc herniation is associated with the A118G polymorphism in the opioid receptor mu 1 gene: evidence of a sex and genotype interaction. (22815498)
2012
11
Health-related quality of life in patients with surgically treated lumbar disc herniation: 2- and 7-year follow-up of 117 patients. (21434763)
2011
12
Full endoscopic contralateral transforaminal discectomy for distally migrated lumbar disc herniation. (21442187)
2011
13
Outcomes and adverse events from physiotherapy functional restoration for lumbar disc herniation with associated radiculopathy. (21091049)
2011
14
Lumbar disc herniation in the Spine Patient Outcomes Research Trial: does educational attainment impact outcome? (21311402)
2011
15
Efficacy and safety of surgery for lumbar disc herniation in patients aged 80 and older. (21534198)
2011
16
Optimal technique of three-dimensional MRI of the lumbar nerve root and its radicular vein in normal and lumbar disc herniation patients. (21740836)
2011
17
The Professional Athlete Spine Initiative: outcomes after lumbar disc herniation in 342 elite professional athletes. (21269889)
2011
18
A study of the relationship between type of lumbar disc herniation, straight leg raising test and peripheral T lymphocytes. (22009908)
2010
19
Acquired hemophilia a in a patient with lumbar disc herniation: a case report and review of the literature. (19365240)
2009
20
Detection of residual disc hernia material and confirmation of nerve root decompression at lumbar disc herniation surgery by intraoperative ultrasound. (19376637)
2009
21
Endoscopic transforaminal suprapedicular approach in high grade inferior migrated lumbar disc herniation. (19274114)
2009
22
Morphological changes of the multifidus muscle in patients with symptomatic lumbar disc herniation. (19951024)
2009
23
Surgical treatment of recurrent lumbar disc herniation by transforaminal lumbar interbody fusion. (18357449)
2009
24
Association of the tag SNPs in the human SKT gene (KIAA1217) with lumbar disc herniation. (19338451)
2009
25
The cost effectiveness of surgical versus nonoperative treatment for lumbar disc herniation over two years: evidence from the Spine Patient Outcomes Research Trial (SPORT). (18777603)
2008
26
Lumbar periradicular abscess mimicking a fragmented lumbar disc herniation : an unusual case. (19137084)
2008
27
Changes in the total Oswestry Index and its ten items in females and males pre- and post-surgery for lumbar disc herniation: a 1-year follow-up. (16912888)
2007
28
Spontaneous resorption in recurrent intradural lumbar disc herniation. Case report. (17561749)
2007
29
Outcome of revision discectomies following recurrent lumbar disc herniation. (16741457)
2006
30
Traditional electrodiagnostic testing in lumbar disc herniation. (16796822)
2006
31
Indication of posterior lumbar interbody fusion for lumbar disc herniation. (16760783)
2006
32
Lateral transmuscular or combined interlaminar/paraisthmic approach to lateral lumbar disc herniation? A comparative clinical series of 48 patients. (15965204)
2005
33
Synchronous lumbar disc herniation in adult twins. Case report. (15595266)
2004
34
Efficacy of serotonin receptor blocker for symptomatic lumbar disc herniation. (12782871)
2003
35
Proximal neuromuscular impairment in lumbar disc herniation: a prospective controlled study. (12811273)
2003
36
Packing of intervertebral spaces with oxidized regenerated cellulose to prevent the recurrence of lumbar disc herniation. (12699554)
2003
37
Lumbar disc herniation in early childhood: case report and literature review. (12715195)
2003
38
Occupational risk factors for symptomatic lumbar disc herniation; a case-control study. (14573712)
2003
39
Trunk muscle strength in flexion, extension, and axial rotation in patients managed with lumbar disc herniation surgery and in healthy control subjects. (12768151)
2003
40
Recovery of motor deficits after microdiscectomy for lumbar disc herniation. (12358369)
2002
41
Cauda equina syndrome as a postoperative complication in five patients operated for lumbar disc herniation. (11224866)
2001
42
Eight year outcome after surgery for lumbar disc herniation: a comparison of reoperated and not reoperated patients. (11534678)
2001
43
Alkaptonuria with lumbar disc herniation: a report of two cases. (10954648)
2000
44
Muscle fiber type distribution in multifidus muscle in cases of lumbar disc herniation. (11132916)
2000
45
Markers of nerve tissue injury in the cerebrospinal fluid in patients with lumbar disc herniation and sciatica. (10222523)
1999
46
Brucella disc infection mimicking lumbar disc herniation: a case report. (10645133)
1999
47
Diagnosis and prognosis in lumbar disc herniation. (10212604)
1999
48
Far lateral lumbar disc herniation. The key to the intertransverse approach. (9393908)
1997
49
The inflammatory properties of contained and noncontained lumbar disc herniation. (9383853)
1997
50
A urodynamic study of cauda equina syndrome due to lumbar disc herniation. (7385464)
1980

Variations for Lumbar Disc Herniation

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Sources:
65UniProtKB/Swiss-Prot
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UniProtKB/Swiss-Prot genetic disease variations for Lumbar Disc Herniation:

65
id Symbol AA change Variation ID SNP ID
1COL9A2p.Gln326TrpVAR_012658

Expression for genes affiliated with Lumbar Disc Herniation

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lumbar Disc Herniation

Search GEO for disease gene expression data for Lumbar Disc Herniation.

Pathways for genes affiliated with Lumbar Disc Herniation

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Sources:
51PathCards, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 13EMD Millipore
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Pathways related to Lumbar Disc Herniation according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7COL11A1, COL9A2
2
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.3MMP3, MMP13
39.2ACAN, COL9A2
49.1ACAN, MMP3
59.0ACAN, MMP13
6
Show member pathways
9.0MMP3, MMP13, THBS2
7
Show member pathways
8.6COL11A1, COL9A2, MMP3, MMP13
8
Show member pathways
8.6MMP13, MMP3, COL9A2, COL11A1
9
Show member pathways
8.5MMP13, MMP3, ACAN
10
Show member pathways
7.8COL11A1, COL9A2, ACAN, MMP3, MMP13

Compounds for genes affiliated with Lumbar Disc Herniation

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Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 52PharmGKB, 25HMDB, 30IUPHAR
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Compounds related to Lumbar Disc Herniation according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1(4-aminophenyl)mercuric acetate469.7MMP13, MMP3
2thermolysin469.7MMP13, MMP3
3uk 383367629.7MMP13, MMP3
4gi 254023x629.7MMP13, MMP3
5gm 6001629.7MMP13, MMP3
6sulfonamide469.7MMP13, MMP3
7hydroxamate469.6MMP13, MMP3
8marimastat46 62 1211.6MMP13, MMP3
9alendronate46 52 1211.6MMP3, MMP13
10ndga469.6MMP3, MMP13
11batimastat46 62 1211.5MMP13, MMP3
12safranin o469.5ACAN, MMP3
13keratan sulfate469.5ACAN, MMP3
14doxycycline46 1210.5MMP13, MMP3
15amide469.4MMP13, MMP3
16chondroitin46 2510.4ACAN, MMP3
17p002469.2MMP13, MMP3
18oligonucleotide469.1COL11A1, MMP13, THBS2
19heparin46 30 25 1212.1MMP3, MMP13, THBS2
20prednisolone46 30 1211.0MMP3, MMP13
21alginate468.9MMP13, MMP3, ACAN
22glucosamine46 25 1210.9ACAN, MMP3, MMP13
23chondroitin sulfate46 259.9MMP13, MMP3, ACAN
24glycosaminoglycan468.9MMP13, MMP3, ACAN
25hyaluronic acid46 259.9ACAN, MMP3, MMP13
26glyceraldehyde 3-phosphate468.9ACAN, MMP3, MMP13
27ascorbic acid46 259.8ACAN, MMP3, MMP13
28sb 20358046 629.8ACAN, MMP3, MMP13
29pd 98,059468.8MMP13, MMP3, ACAN
30pge2468.7ACAN, MMP3, MMP13
31procollagen468.5ACAN, MMP3, MMP13, THBS2
32tgf beta1468.5ACAN, MMP3, MMP13, THBS2
33dexamethasone46 52 30 1211.5ACAN, MMP3, MMP13

GO Terms for genes affiliated with Lumbar Disc Herniation

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17Gene Ontology
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Cellular components related to Lumbar Disc Herniation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055788.5ACAN, MMP3, MMP13
2extracellular regionGO:0055767.1COL11A1, COL9A2, ACAN, MMP3, MMP13, THBS2

Biological processes related to Lumbar Disc Herniation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1skeletal system developmentGO:0015019.2COL9A2, ACAN
2collagen catabolic processGO:0305748.6MMP13, MMP3, COL9A2, COL11A1
3proteolysisGO:0065088.2ACAN, MMP3, MMP13
4extracellular matrix disassemblyGO:0226177.8COL11A1, COL9A2, ACAN, MMP3, MMP13
5extracellular matrix organizationGO:0301987.7MMP13, MMP3, ACAN, COL9A2, COL11A1

Molecular functions related to Lumbar Disc Herniation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:0052019.2COL11A1, ACAN
2metalloendopeptidase activityGO:0042229.0MMP3, MMP13
3calcium ion bindingGO:0055099.0MMP3, MMP13, THBS2

Products for genes affiliated with Lumbar Disc Herniation

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Sources for Lumbar Disc Herniation

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet