MCID: LMB052
MIFTS: 16

Lumbar Disc Herniation malady

Summaries for Lumbar Disc Herniation

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A spinal disc herniation (in Latin prolapsus disci intervertebralis, commonly called a slipped disc... more...

MalaCards: Lumbar Disc Herniation is related to cauda equina syndrome and radiculopathy. An important gene associated with Lumbar Disc Herniation is COL11A1 (collagen, type XI, alpha 1), and among its related pathways are PI3K-Akt signaling pathway and Focal Adhesion. The compound oligonucleotide have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and limbs/digits/tail.

Description from OMIM:46 603932

Aliases & Classifications for Lumbar Disc Herniation

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46OMIM
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Aliases & Descriptions:

lumbar disc herniation 46


Related Diseases for Lumbar Disc Herniation

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17GeneCards, 18GeneDecks
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Diseases related to Lumbar Disc Herniation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 28)
idRelated DiseaseScoreTop Affiliating Genes
1cauda equina syndrome10.9
2radiculopathy10.7
3spinal stenosis10.7
4alkaptonuria10.5
5degenerative disc disease10.5
6cervicitis10.4
7hemangioma10.4
8obesity10.4
9discitis10.2
10cystic fibrosis10.2
11ankylosing spondylitis10.2
12arachnoiditis10.2
13intracranial hypotension10.2
14spondylosis10.2
15spondylolysis10.2
16neuronitis10.2
17ochronosis10.2
18aortic aneurysm10.2
19arthritis10.2
20capillary disease10.2
21capillary hemangioma10.2
22chondroma10.2
23hypertension10.2
24rheumatoid arthritis10.2
25ruptured aortic aneurysm10.2
26spondylitis10.2
27hemophilia10.2
28squamous cell carcinoma10.0THBS2, COL11A1

Graphical network of the top 20 diseases related to Lumbar Disc Herniation:



Diseases related to lumbar disc herniation

Clinical Features for Lumbar Disc Herniation

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46OMIM
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Clinical features from OMIM:

603932

Drugs & Therapeutics for Lumbar Disc Herniation

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Lumbar Disc Herniation

Search CenterWatch for Lumbar Disc Herniation

Genetic Tests for Lumbar Disc Herniation

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Anatomical Context for Lumbar Disc Herniation

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Animal Models for Lumbar Disc Herniation or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lumbar Disc Herniation:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.1THBS2, COL11A1
2MP:00053718.8THBS2, COL11A1

Publications for Lumbar Disc Herniation

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Genetic Variations for Lumbar Disc Herniation

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Lumbar Disc Herniation:

62
id Symbol AA change Variation ID SNP ID
1COL9A2p.Gln326TrpVAR_012658

Expression for genes affiliated with Lumbar Disc Herniation

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lumbar Disc Herniation

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Pathways for genes affiliated with Lumbar Disc Herniation

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Lumbar Disc Herniation according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1THBS2, COL11A1
2
Hide members
9.1THBS2, COL11A1

Compounds for genes affiliated with Lumbar Disc Herniation

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44Novoseek
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Compounds related to Lumbar Disc Herniation according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1oligonucleotide449.1THBS2, COL11A1

GO Terms for genes affiliated with Lumbar Disc Herniation

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Products for genes affiliated with Lumbar Disc Herniation

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lumbar Disc Herniation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet