MCID: LNG029
MIFTS: 49

Lung Adenocarcinoma malady

Respiratory diseases category

Summaries for Lung Adenocarcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Adenocarcinoma of the lung (pulmonary adenocarcinoma) is a common histological form of lung cancer that... more...

MalaCards: Lung Adenocarcinoma, also known as adenocarcinoma of lung, is related to adenocarcinoma and lung cancer. An important gene associated with Lung Adenocarcinoma is KRAS (Kirsten rat sarcoma viral oncogene homolog), and among its related pathways is Dorso-ventral axis formation. The compounds mucicarmine and panitumumab have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and colon.

Aliases & Classifications for Lung Adenocarcinoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

lung adenocarcinoma 8 42
adenocarcinoma of lung 8 42 60
non-small cell adenocarcinoma 60
nonsmall cell adenocarcinoma 8
adenocarcinoma lung 44


External Ids:

Disease Ontology8 DOID:3910
MeSH34 C538231
SNOMED-CT56 254626006
NCIt39 C3512

Related Diseases for Lung Adenocarcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lung Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.2CEACAM7, KRAS, XAGE1D, FIGF, NKX2-1, EGFR
2lung cancer31.2NAPSA, CEACAM7, KRAS, NKX2-1, EGFR
3squamous cell carcinoma30.8NKX2-1, S100A2, FIGF, KRAS, CEACAM7, EGFR
4gastric adenocarcinoma30.4FIGF, KRAS, CEACAM7
5colon adenocarcinoma30.4KRAS, CEACAM7
6malignant mesothelioma30.3NKX2-1
7sarcoma30.2KRAS
8melanoma30.1S100A2, NKX2-1, FIGF, XAGE1D, KRAS, CEACAM7
9colorectal cancer30.1KRAS, CEACAM7, FIGF, EGFR
10prostate cancer29.9S100A2, EGFR, FIGF, XAGE1D, KRAS
11breast cancer29.9CEACAM7, KRAS, FIGF, EGFR, NKX2-1
12large cell carcinoma29.9KRAS, CEACAM7, EGFR, NKX2-1
13cervical cancer29.9EGFR, KRAS, CEACAM7
14colon cancer29.9KRAS, EGFR, FIGF, CEACAM7
15cervical adenocarcinoma29.8CEACAM7
16lung squamous cell carcinoma10.5
17mucinous adenocarcinoma10.5
18lung papillary adenocarcinoma10.4
19adenocarcinoma in situ10.4
20papillary adenocarcinoma10.4
21thyroiditis10.4
22lung lymphoma10.3
23breast adenocarcinoma10.3
24meningitis10.2
25thoracic cancer10.2
26obstructive jaundice10.2
27esophagitis10.2
28interstitial lung disease10.2
29lung sarcoma10.2
30pneumothorax10.2
31adenocarcinoma of lung, somatic10.1
32adenocarcinoma of lung, response to tyrosine kinase inhibitor in10.1
33neuroendocrine carcinoma10.1
34lung occult adenocarcinoma10.1
35choroiditis10.1
36lambert-eaton myasthenic syndrome10.1
37signet ring cell adenocarcinoma10.1
38xeroderma pigmentosum10.1
39actinomycosis10.1
40lung acinar adenocarcinoma10.1
41bronchogenic lung adenocarcinoma10.1
42adenoid cystic carcinoma10.1
43lung adenoid cystic carcinoma10.1
44adenoiditis10.1
45dermatomyositis10.1
46malignant pleural mesothelioma10.1
47pancreatitis10.1
48prostate adenocarcinoma10.1
49prostatitis10.1
50lung small cell carcinoma10.0CEACAM7, XAGE1D, NKX2-1, EGFR, KRAS

Graphical network of the top 20 diseases related to Lung Adenocarcinoma:



Diseases related to lung adenocarcinoma

Clinical Features for Lung Adenocarcinoma

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Drugs & Therapeutics for Lung Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lung Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Lung Adenocarcinoma

Search NIH Clinical Center for Lung Adenocarcinoma

Search CenterWatch for Lung Adenocarcinoma

Genetic Tests for Lung Adenocarcinoma

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Anatomical Context for Lung Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Lung Adenocarcinoma:

32
Lung, Brain, Colon, Thyroid, Endothelial, Lymph node, Prostate, Bone, Breast, Testes, T cells, Pancreas, Nk cells, Pituitary, Fetal lung, B cells, Monocytes, Spinal cord, Skin, Cervix, Kidney, Placenta, Bone marrow, Whole blood, Smooth muscle, Myeloid, Pineal

Animal Models for Lung Adenocarcinoma or affiliated genes

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Publications for Lung Adenocarcinoma

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50PubMed
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Articles related to Lung Adenocarcinoma:

(show top 50)    (show all 1813)
idTitleAuthorsYear
1
Cribriform adenocarcinoma of the lung: clinicopathologic, immunohistochemical, and molecular analysis of 15 cases of a distinctive morphologic subtype of lung adenocarcinoma. (24390215)
2014
2
The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis. (24428777)
2014
3
Network-based differential gene expression analysis suggests cell cycle related genes regulated by E2F1 underlie the molecular difference between smoker and non-smoker lung adenocarcinoma. (24341432)
2013
4
Erythropoietin receptor expression is a potential prognostic factor in human lung adenocarcinoma. (24155958)
2013
5
Sequential treatment of advanced-stage lung adenocarcinoma harboring wild-type EGFR gene: second-line pemetrexed followed by third-line erlotinib versus the reverse sequence. (23898110)
2013
6
Experimental study of endostar injection concomitant with cryoablation on lung adenocarcinoma a549 xenografts. (24377591)
2013
7
Thromboxane A2 receptor-mediated release of matrix metalloproteinase-1 (MMP-1) induces expression of monocyte chemoattractant protein-1 (MCP-1) by activation of protease-activated receptor 2 (PAR2) in A549 human lung adenocarcinoma cells. (23475608)
2013
8
Gene expression signature of non-involved lung tissue associated with survival in lung adenocarcinoma patients. (23978379)
2013
9
Sex disparities in the association of lung adenocarcinoma with colorectal cancer. (24312138)
2013
10
Anacardic acid induces mitochondrial-mediated apoptosis in the A549 human lung adenocarcinoma cells. (23314312)
2013
11
Expression of Notch-1 and its clinical significance in different histological subtypes of human lung adenocarcinoma. (24423157)
2013
12
MicroRNAs associated with tumour migration, invasion and angiogenic properties in A549 and SK-Lu1 human lung adenocarcinoma cells. (24360396)
2013
13
Rapid increase of serum neuron specific enolase level and tachyphylaxis of EGFR-tyrosine kinase inhibitor indicate small cell lung cancer transformation from EGFR positive lung adenocarcinoma? (23683536)
2013
14
p14(ARF) inhibits the growth of lung adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling pathway. (22450744)
2013
15
IGF-1R and Bmi-1 expressions in lung adenocarcinoma and their clinicopathologic and prognostic significance. (23990442)
2013
16
Reduced expression of KrA1ppel-like factor 17 is related to tumor growth and poor prognosis in lung adenocarcinoma. (22240024)
2012
17
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. (22797724)
2012
18
Napsin A is an independent prognostic factor in surgically resected adenocarcinoma of the lung. (22418245)
2012
19
Interleukin-1 beta and transforming growth factor-beta 3 cooperate to activate matrix metalloproteinase expression and invasiveness in A549 lung adenocarcinoma cells. (22796605)
2012
20
EML4-ALK translocation predicts better outcome in lung adenocarcinoma patients with wild-type EGFR. (22124476)
2012
21
Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma. (22370939)
2012
22
Comparative profiling of miRNA expression of lung adenocarcinoma cells in two-dimensional and three-dimensional cultures. (23036707)
2012
23
Radioimmunoimaging with mixed monoclonal antibodies of nude mice bearing human lung adenocarcinoma xenografts. (23167324)
2012
24
Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL- 1/4.1B). (21131357)
2011
25
Aberrant CDX2 expression and metastatic endometrial adenocarcinoma to the lung. (22234143)
2011
26
Localization of the invadopodia-related proteins actinin-1 and cortactin to matrix-contact-side cytoplasm of cancer cells in surgically resected lung adenocarcinomas. (21474972)
2011
27
Effect of gefitinib on the survival of patients with recurrence of lung adenocarcinoma after surgery: a retrospective case-matching cohort study. (20705455)
2010
28
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. (19576624)
2009
29
EGFR gene copy number in adenocarcinoma of the lung by FISH analysis: investigation of significantly related factors on CT, FDG-PET, and histopathology. (18819724)
2009
30
Comparison of FISH, PCR, and immunohistochemistry in assessing EGFR status in lung adenocarcinoma and correlation with clinicopathologic features. (19704257)
2009
31
Lung adenocarcinoma with good response to erlotinib after gefitinib treatment failure and acquired T790M mutation. (18379370)
2008
32
Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung. (17904685)
2008
33
Expression of multidrug resistance-related proteins p-glycoprotein, glutathione-s-transferases, topoisomerase-II and lung resistance protein in primary gastric cardiac adenocarcinoma. (19102336)
2008
34
Gross cystic disease fluid protein-(GCDFP-15): expression in primary lung adenocarcinoma. (18300807)
2008
35
Relation of vascular endothelial growth factor-D expression to microvessel density, microlymphatic vessel density, and lymph-node metastasis of lung adenocarcinoma]. (19080666)
2008
36
Hypermethylation of the Dal-1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. (17415786)
2007
37
CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma. (17785447)
2007
38
Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma. (16510572)
2006
39
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. (16705038)
2006
40
Gender difference in the activity but not expression of estrogen receptors alpha and beta in human lung adenocarcinoma cells. (16601283)
2006
41
Somatic mutations in epidermal growth factor receptor underlying complete responsiveness to gefitinib in a Taiwanese female patient with metastatic adenocarcinoma of lung. (16027522)
2005
42
Gene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung. (16189154)
2005
43
Intrapulmonary IFN-beta gene therapy using an adenoviral vector is highly effective in a murine orthotopic model of bronchogenic adenocarcinoma of the lung. (16166316)
2005
44
Effects of transfected SOCS3 gene on proliferation of human lung adenocarcinoma cell line A549]. (15363199)
2004
45
Intercellular adhesion molecules (ICAM-1, VCAM-1, and LFA-1) in adenocarcinoma of lung. Technical aspects. (12415699)
2003
46
omega-hydroxylation activity toward leukotriene B(4) and polyunsaturated fatty acids in the human hepatoblastoma cell line, HepG2, and human lung adenocarcinoma cell line, A549. (11056396)
2000
47
Increased cyclooxygenase 2 (COX-2) expression occurs frequently in precursor lesions of human adenocarcinoma of the lung. (11086200)
2000
48
k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis. (10493509)
1999
49
Adenosquamous carcinoma of the lung. Surgical results compared with squamous cell and adenocarcinoma. (10093856)
1999
50
Estimation of serum level of pS2 protein in patients with lung adenocarcinoma. (8694568)
1996

Genetic Variations for Lung Adenocarcinoma

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Expression for genes affiliated with Lung Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Adenocarcinoma

Search GEO for disease gene expression data for Lung Adenocarcinoma.

Pathways for genes affiliated with Lung Adenocarcinoma

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29KEGG
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Pathways related to Lung Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8KRAS, EGFR

Compounds for genes affiliated with Lung Adenocarcinoma

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Lung Adenocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mucicarmine4410.8CEACAM7, NKX2-1
2panitumumab44 49 1112.7KRAS, EGFR
3gefitinib44 49 1112.6CEACAM7, KRAS, EGFR

GO Terms for genes affiliated with Lung Adenocarcinoma

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16Gene Ontology
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Biological processes related to Lung Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex cell migrationGO:02179510.8NKX2-1, EGFR

Products for genes affiliated with Lung Adenocarcinoma

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Sources for Lung Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet