MCID: LNG029
MIFTS: 42

Lung Adenocarcinoma malady

Rare diseases, Cancer diseases, Respiratory diseases categories
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Summaries for Lung Adenocarcinoma

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Adenocarcinoma of the lung (pulmonary adenocarcinoma) is a common histological form of lung cancer that... more...

MalaCards: Lung Adenocarcinoma, also known as adenocarcinoma of lung, is related to adenocarcinoma and lung cancer. An important gene associated with Lung Adenocarcinoma is KRAS (Kirsten rat sarcoma viral oncogene homolog), and among its related pathways is MicroRNAs in cancer. Affiliated tissues include lung, brain and endothelial.

Aliases & Classifications for Lung Adenocarcinoma

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8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

lung adenocarcinoma 8 43
adenocarcinoma of lung 8 43 62
non-small cell adenocarcinoma 62
nonsmall cell adenocarcinoma 8
adenocarcinoma lung 45


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Disease Ontology8 DOID:3910
NCIt40 C3512
SNOMED-CT58 254626006
MeSH35 C538231

Related Diseases for Lung Adenocarcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lung Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.3NAPSA, XAGE1D, KRAS
2lung cancer30.9KRAS, NAPSA
3hypoxia10.6
4endotheliitis10.5
5thyroiditis10.4
6adenocarcinoma in situ10.3
7paraneoplastic syndromes10.3
8meningitis10.3
9obstructive jaundice10.2
10esophagitis10.2
11interstitial lung disease10.2
12malignant mesothelioma10.2
13pneumothorax10.2
14sarcoma10.2
15adenocarcinoma of lung, somatic10.2
16adenocarcinoma of lung, response to tyrosine kinase inhibitor in10.2
17neuroendocrine carcinoma10.1
18actinomycosis10.1
19adenoiditis10.1
20choroiditis10.1
21lambert-eaton myasthenic syndrome10.1
22xeroderma pigmentosum10.1
23adenoid cystic carcinoma10.1
24bronchogenic lung adenocarcinoma10.1
25colorectal cancer10.1
26dermatomyositis10.1
27melanoma10.1
28pancreatitis10.1
29prostatitis10.1
30b-cell lymphomas10.1
31testicular cancer10.1KRAS, XAGE1D
32papillary adenocarcinoma10.0
33polymorphous low-grade adenocarcinoma10.0
34rhabdoid tumor10.0
35non-small cell lung carcinoma10.0XAGE1D, XAGE1C, XAGE1A, XAGE1E, XAGE1B
36atrioventricular block10.0
37lung occult adenocarcinoma10.0
38maxillary sinus adenoid cystic carcinoma10.0
39myoma10.0
40pulmonary tuberculosis10.0
41newcastle disease10.0
42focal segmental glomerulosclerosis10.0
43mhc class i deficiency10.0
44large cell neuroendocrine carcinoma10.0
45neuronitis10.0
46lymphangitis10.0
47goodpasture syndrome10.0
48lung papillary adenocarcinoma10.0
49brown-sequard syndrome10.0
50asbestosis10.0

Graphical network of the top 20 diseases related to Lung Adenocarcinoma:



Diseases related to lung adenocarcinoma

Symptoms for Lung Adenocarcinoma

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Drugs & Therapeutics for Lung Adenocarcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Lung Adenocarcinoma

Search NIH Clinical Center for Lung Adenocarcinoma

Genetic Tests for Lung Adenocarcinoma

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Anatomical Context for Lung Adenocarcinoma

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33MalaCards
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MalaCards organs/tissues related to Lung Adenocarcinoma:

33
Lung, Brain, Endothelial, Lymph node, Thyroid, Testes, T cells, Breast, Bone, Colon, Nk cells, B cells, Prostate, Spinal cord, Monocytes, Fetal lung, Placenta, Skin, Smooth muscle, Whole blood, Bone marrow, Kidney, Pineal

Animal Models for Lung Adenocarcinoma or affiliated genes

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Publications for Lung Adenocarcinoma

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Sources:
52PubMed
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Articles related to Lung Adenocarcinoma:

(show top 50)    (show all 1428)
idTitleAuthorsYear
1
Psf3 is a prognostic biomarker in lung adenocarcinoma. (23127337)
2013
2
MicroRNA-98 sensitizes cisplatin-resistant human lung adenocarcinoma cells by up-regulation of HMGA2. (23700794)
2013
3
Clinical implications related to preoperative detection of stage IA lung adenocarcinoma. (23497951)
2013
4
Inducing cell proliferation inhibition, apoptosis, and motility reduction by silencing long noncoding ribonucleic acid metastasis-associated lung adenocarcinoma transcript 1 in urothelial carcinoma of the bladder. (23153939)
2013
5
Effect of TRAF6 on the biological behavior of human lung adenocarcinoma cell. (23055197)
2013
6
Network-based differential gene expression analysis suggests cell cycle related genes regulated by E2F1 underlie the molecular difference between smoker and non-smoker lung adenocarcinoma. (24341432)
2013
7
Ground glass opacity and T-factor in staging lung adenocarcinoma. (23242983)
2013
8
Loss of phosphatase and tensin homolog protein expression is an independent poor prognostic marker in lung adenocarcinoma. (22982652)
2012
9
Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinoma. (22302706)
2012
10
Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas. (22080568)
2012
11
Hypoxia upregulates the expression of annexin A1 in lung adenocarcinoma a549 cells]. (22613333)
2012
12
Activation of a Tip60/E2F1/ERCC1 network in human lung adenocarcinoma cells exposed to cisplatin. (22159227)
2012
13
Loss of DBC2 expression is an early and progressive event in the development of lung adenocarcinoma. (22901165)
2012
14
Effusion immunocytochemistry as an alternative approach for the selection of first-line targeted therapy in advanced lung adenocarcinoma. (22525557)
2012
15
High thymidine kinase 1 (TK1) expression is a predictor of poor survival in patients with pT1 of lung adenocarcinoma. (22143937)
2012
16
EGFR mutations predict a favorable outcome for malignant pleural effusion of lung adenocarcinoma with Tarceva therapy. (22134479)
2012
17
Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas. (22200856)
2012
18
The relationship between EGFR gain and VHL loss in lung adenocarcinoma and poor patient survival. (21556796)
2011
19
Overexpression of gelsolin-like actin-capping protein is associated with progression of lung adenocarcinoma. (21908955)
2011
20
Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung. (21464700)
2011
21
Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status. (20150826)
2010
22
Stromal macrophage expressing CD204 is associated with tumor aggressiveness in lung adenocarcinoma. (20802348)
2010
23
Quantitative proteome analysis reveals annexin A3 as a novel biomarker in lung adenocarcinoma. (18798225)
2009
24
Prognostic value of KRAS mutations and Ki-67 expression in stage I lung adenocarcinomas. (19162366)
2009
25
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. (19576624)
2009
26
IL-12 can target human lung adenocarcinoma cells and normal bronchial epithelial cells surrounding tumor lesions. (19582164)
2009
27
Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma. (19040416)
2009
28
Effects of hydroquinone on expression of human 8-oxo-guanine DNA glycosylase mRNA in human A549 lung adenocarcinoma cell strains]. (19535000)
2009
29
ING4 induces cell growth inhibition in human lung adenocarcinoma A549 cells by means of Wnt-1/beta-catenin signaling pathway. (18399550)
2008
30
Lung adenocarcinoma with good response to erlotinib after gefitinib treatment failure and acquired T790M mutation. (18379370)
2008
31
Successful treatment of carcinomatous meningitis with gefitinib in a patient with lung adenocarcinoma harboring a mutated EGF receptor gene. (18441512)
2008
32
Correlation between lymph node metastasis and the expression of VEGF-C, VEGF-D and VEGFR-3 in T1 lung adenocarcinoma. (17970036)
2007
33
Molecular markers and changes of computed tomography appearance in lung adenocarcinoma with ground-glass opacity. (18089646)
2007
34
Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma. (17459062)
2007
35
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. (18060032)
2007
36
Effects of selenium supplementation on expression of glutathione peroxidase isoforms in cultured human lung adenocarcinoma cell lines. (17052796)
2007
37
Overexpression of Dicer in precursor lesions of lung adenocarcinoma. (17332367)
2007
38
HOXB2 as a novel prognostic indicator for stage I lung adenocarcinomas. (17805056)
2007
39
Immunohistochemical alpha- and beta-catenin and E-cadherin expression and their clinicopathological significance in human lung adenocarcinoma. (16843618)
2006
40
Dissimilarity in gene expression profiles of lung adenocarcinoma in Japanese men and women. (17081955)
2006
41
Overexpression of soluble TRAIL induces apoptosis in human lung adenocarcinoma and inhibits growth of tumor xenografts in nude mice. (15753363)
2005
42
Lung adenocarcinoma global profiling identifies type II transforming growth factor-beta receptor as a repressor of invasiveness. (15976377)
2005
43
Lung adenocarcinoma associated with familial adenomatous polyposis. Clear cell carcinoma with beta-catenin accumulation accompanied by atypical adenomatous hyperplasia. (15660284)
2005
44
Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phosphatidylinositol 3-kinase/Akt pathway. (12896906)
2003
45
Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. (11815611)
2002
46
Significant correlation of nitric oxide synthase activity and p53 gene mutation in stage I lung adenocarcinoma. (9738975)
1998
47
A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity. (8577704)
1996
48
Involvement of tyrosine kinase activity in the low-density lipoprotein receptor expression in human lung adenocarcinoma cell line A549. (9116058)
1996
49
Genotypic, phenotypic and biological characterization of a novel human lung adenocarcinoma cell line (LC 89) (8196904)
1994
50
Overexpression of the p53 tumor suppressor gene product in primary lung adenocarcinomas is associated with cigarette smoking. (8434702)
1993

Variations for Lung Adenocarcinoma

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Expression for genes affiliated with Lung Adenocarcinoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Adenocarcinoma

Search GEO for disease gene expression data for Lung Adenocarcinoma.

Pathways for genes affiliated with Lung Adenocarcinoma

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50PathCards, 30KEGG
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Pathways related to Lung Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7KRAS, MIR200A, MIR100

Compounds for genes affiliated with Lung Adenocarcinoma

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GO Terms for genes affiliated with Lung Adenocarcinoma

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Products for genes affiliated with Lung Adenocarcinoma

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Sources for Lung Adenocarcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet