Lung Adenocarcinoma malady

MalaCards: Lung Adenocarcinoma, also known as adenocarcinoma of lung (disorder), is related to adenocarcinoma and carcinoma. An important gene associated with Lung Adenocarcinoma is KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), and among its related pathways are Apoptosis and Autophagy and Cell Cycle / Checkpoint Control. The drugs mitomycin and thiotepa and the compounds calcium and cysteine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and brain, and related mouse phenotypes are growth/size and mortality/aging.

Aliases & Descriptions:

lung adenocarcinoma 6 30 8 adenocarcinoma of lung (disorder) 6 43 adenocarcinoma of lung 7 30 non-small cell adenocarcinoma 43

nonsmall cell adenocarcinoma 6 adenocarcinoma lung 32 adenocarcinoma 43

Diseases related to lung adenocarcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1014)

id	Related Disease	Score	Top Affiliating Genes
1	adenocarcinoma	86.4	PIP, PIK3CA, PIK3CG, LRG1, LRMP, LRP1
2	carcinoma	71.7	PIP, PIK3CA, PIK3CG, LRP1, KLF6, NDN
3	prostatitis	55.2	PIP, PIK3CA, PIK3CG, LRP1, KLF6, NDN
4	pancreatitis	48.9	PIK3CA, PIK3CG, LRG1, LRP1, KLF6, VWF
5	melanoma	47.7	PIK3CA, PIK3CG, LRP1, KLF6, NDN, VWF
6	lung carcinoma	47.2	PIK3CA, PIK3CG, KLF6, RDX, SFTPB, SFTPD
7	cervicitis	47.0	PIK3CA, PIK3CG, VWF, PCNA, RB1, RBL2
8	hepatitis	46.9	PIK3CA, PIK3CG, LRMP, LRP1, KLF6, VWF
9	leukemia	46.2	PIK3CA, PIK3CG, LRP1, KLF6, VWF, SFTPD
10	gastric cancer	45.8	PIK3CA, PIK3CG, KLF6, VWF, PCNA, RB1
11	adenoma	45.6	PIK3CA, LRMP, SFTPC, PCNA, RB1, SETD2
12	hepatocellular carcinoma	45.4	PIK3CA, PIK3CG, KLF6, VWF, PCNA, RB1
13	hypoxia	45.1	PIK3CA, PIK3CG, LRP1, NDN, VWF, SFTPB
14	thyroiditis	45.0	PIK3CA, PIK3CG, LRP1, NDN, VWF, SFTPB
15	neuronitis	44.3	PIK3CA, PIK3CG, LRP1, KLF6, NDN, CNTN1
16	esophagitis	43.5	PIK3CA, PIK3CG, LRMP, KLF6, CNTN1, SFTPD
17	colon adenocarcinoma	43.5	BSG, VEGFA, VCL, MYC, BMP6, RARB
18	breast carcinoma	42.8	PIP, PIK3CA, PIK3CG, LRP1, VWF, RDX
19	pancreatic ductal adenocarcinoma	41.8	SERPINB5, VIM, BRAF, VEGFA, VEGFC, MYC
20	gastric adenocarcinoma	41.7	PIK3CA, SERPINB5, VEGFC, MYC, BID, BIRC5
21	colon cancer	41.6	PIK3CA, PIK3CG, KLF6, VWF, PCNA, RB1
22	endometrial adenocarcinoma	40.4	PIK3CA, PCNA, RB1, VIM, BRAF, VEGFA
23	ovarian carcinoma	40.3	PIP, PIK3CA, PIK3CG, NDN, PCNA, RB1
24	esophageal squamous cell carcinoma	39.6	PIK3CA, PCNA, RB1, SELE, SETD2, BSG
25	cholangiocarcinoma	38.2	PIK3CA, PIK3CG, PCNA, RB1, SELE, SERPINB5
26	barrett's esophagus	37.2	MUC2, MUC5AC, MUC6, S100A8, CDKN2A, CDX2
27	cervical adenocarcinoma	36.2	PCNA, BRAF, MYC, RASSF1, PARP1, MUC16
28	barrett's adenocarcinoma	36.2	PCNA, BRAF, VEGFA, MYC, BIRC5, MUC5AC
29	clear cell adenocarcinoma	35.8	PIK3CA, RB1, VEGFA, BIRC5, MUC16, MTOR
30	papillary adenocarcinoma	35.6	PIP, PCNA, VIM, MYC, MUC1, MUC16
31	renal cell carcinoma	35.5	PIK3CA, PCNA, SETD2, VIM, BSG, NAPSA
32	fibrosis	35.5	PIK3CA, PIK3CG, LRG1, LRP1, KLF6, VWF
33	endocervicitis	35.4	VIM, MYC, BCL2, MUC1, MUC16, MUC5AC
34	breast adenocarcinoma	35.3	PCNA, RB1, VEGFA, BMP6, PARP1, BCL2
35	malignant mesothelioma	34.9	PIK3CG, SFTPB, PCNA, RB1, VIM, NAPSA
36	colon carcinoma	34.8	PIK3CA, PIK3CG, SELE, SETD2, BRAF, VEGFA
37	endometrial carcinoma	34.7	PIK3CA, PIK3CG, LRP1, PCNA, RB1, SERPINB5
38	pancreatic cancer	34.4	SERPINB5, VEGFA, RAF1, RAC1, BIRC5, KDR
39	sarcoma	34.4	PIK3CA, PIK3CG, VWF, SFTPB, PCNA, RB1
40	small cell carcinoma	34.3	KLF6, PCNA, RB1, VIM, VEGFA, RASSF1
41	cervical cancer	34.2	PIK3CA, PIK3CG, PCNA, RB1, RBL2, SETD2
42	gallbladder adenocarcinoma	34.2	SELE, BRAF, MYC, MUC1, MUC2, BAX
43	thyroid carcinoma	34.1	PIK3CA, PIK3CG, RDX, PCNA, RB1, SELE
44	adenocarcinoma in situ	33.8	VIM, CEACAM5, CEACAM7, CDKN1A, CDKN2A, CDX2
45	squamous cell carcinoma	33.8	CDH1, MMP10, MKI67, GSTP1, CCND1, TP73
46	intrahepatic cholangiocarcinoma	33.7	RB1, SERPINB5, SERPINA3, BSG, VEGFC, RAD9A
47	endometriosis	33.7	PIK3CA, PCNA, SEMA3C, VIM, BSG, BRAF
48	peritonitis	33.5	LRG1, LRP1, VWF, PCNA, SELE, SETD2
49	esophagus adenocarcinoma	33.5	BCL2, S100A8, CDKN1A, CDKN2A, MKI67, CCND1
50	ovarian clear cell adenocarcinoma	33.5	PIK3CA, VEGFA, MUC16, MTOR, CDH1, INHBA

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 mitomycin, thiotepa

MalaCards organs/tissues related to lung adenocarcinoma:

²²

MGI Mouse Phenotypes related to lung adenocarcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	21.4	PIK3CA, PIK3CG, LRP1, KLF6, CNTN1, SFTPC
2	mortality/aging	MP:0010768	20.1	PIK3CA, LRP1, KLF6, NDN, CNTN1, VWF
3	homeostasis/metabolism phenotype	MP:0005376	18.9	PIK3CA, PIK3CG, LRP1, NDN, VWF, RDX
4	cellular phenotype	MP:0005384	18.8	PIK3CA, PIK3CG, KLF6, NDN, CNTN1, VWF
5	immune system phenotype	MP:0005387	18.1	LRP1, VWF, VIM, BSG, BRAF, BMI1
6	hematopoietic system phenotype	MP:0005397	17.3	KLF6, PCNA, BRAF, BMI1, BID, BIRC2
7	embryogenesis phenotype	MP:0005380	16.4	PIK3CA, KLF6, RBL2, SEMA3C, SETD2, SERPINB5
8	nervous system phenotype	MP:0003631	16.3	LRP1, NDN, CNTN1, VWF, RDX, RB1
9	behavior/neurological phenotype	MP:0005386	15.7	PIK3CA, LRP1, NDN, CNTN1, RDX, SFTPB
10	reproductive system phenotype	MP:0005389	15.6	PIK3CA, KLF6, SFTPC, RBL2, VEGFA, RARB
11	cardiovascular system phenotype	MP:0005385	15.5	PIK3CA, PIK3CG, LRP1, KLF6, VWF, SFTPC
12	digestive/alimentary phenotype	MP:0005381	15.4	VWF, RB1, BRAF, VEGFA, VCL, MYC
13	integument phenotype	MP:0010771	15.0	PIK3CG, KLF6, NDN, RB1, RBL2, BRAF
14	tumorigenesis	MP:0002006	14.9	PIK3CA, SFTPC, RB1, RBL2, BRAF, MYC
15	endocrine/exocrine gland phenotype	MP:0005379	13.7	RBL2, BDKRB2, LDHC, LDLR, UCN3, XPA
16	limbs/digits/tail phenotype	MP:0005371	13.6	RB1, RBL2, VEGFA, VCL, BMI1, RARB
17	skeleton phenotype	MP:0005390	13.6	PIK3CG, LRP1, RB1, RBL2, BRAF, VEGFA
18	craniofacial phenotype	MP:0005382	13.3	BMI1, BDNF, LAMA3, LAMP2, XPA, CDKN1C
19	normal phenotype	MP:0002873	13.1	LRP1, NDN, RBL2, SELE, BRAF, VEGFA
20	muscle phenotype	MP:0005369	12.6	PIK3CA, PIK3CG, LRP1, NDN, CNTN1, RB1
21	no phenotypic analysis	MP:0003012	12.5	NDN, SFTPC, PCNA, RB1, RBL2, VEGFA
22	vision/eye phenotype	MP:0005391	12.4	PIK3CA, CNTN1, SFTPC, RB1, RBL2, SELE
23	renal/urinary system phenotype	MP:0005367	12.4	BRAF, RARB, CLU, BDKRB2, BCL2, BCL2L11
24	respiratory system phenotype	MP:0005388	12.1	NDN, SFTPC, SFTPD, LPL, BID, BDNF
25	pigmentation phenotype	MP:0001186	11.6	RB1, SEMA3C, BRAF, MYC, RAD9A, RAC1
26	liver/biliary system phenotype	MP:0005370	11.4	KLF6, RDX, VEGFA, LPL, BID, BCAR1
27	other phenotype	MP:0005395	11.2	RARB, CLU, KDR, LDLR, LAMA4, LAMC2
28	hearing/vestibular/ear phenotype	MP:0005377	11.2	RDX, RB1, MYC, RARB, PARP1, BDNF
29	adipose tissue phenotype	MP:0005375	9.3	PIK3CA, LRP1, RB1, BRAF, LPL, MYC

Articles related to lung adenocarcinoma:

(show top 50)    (show all 720)

id	Title	Authors	Year	Affiliating Genes
1	Detection of epithelial growth factor receptor mutati ons in cerebrospinal fluid from patients with lung adenocarcinoma suspected of neoplastic meningitis. (21610522)	Shingyoji M.... Iizasa T.	2011	EGFR
2	Expression of xeroderma pigmentosum complementation g roup C protein predicts cisplatin resistance in lung adenocarcinoma patients. (21327329)	Lai T.C.... Ho S.P.	2011	XPC
3	The role of pemetrexed in lung adenocarcinoma, mixed subtype with bronchioloalveolar carcinoma features. (19839924)	Duruisseaux M.... Arpin D.	2010	FOLR1
4	Prognostic and predictive implications of EGFR mutati ons, EGFR copy number and KRAS mutations in advanced stage lung adenocarcinoma. (21187500)	Bonanno L.... Favaretto A.	2010	EGFR, KRAS
5	Application of laser capture microdissection and surface-enhanced laser desorption ionization time-of-flight mass spectrometry to screen biomarkers for early diagnosis of lung adenocarcinoma (19292069)	Tian Y.X.... Zheng S.	2009	CCL26
6	Comparison of DNA-dependent protein kinase catalytic subunit expression in two lung adenocarcinoma cell lines with different radios ensitivity (19923078)	Cen W.J.... Yang S.Q.	2009	PRKDC, CIB1
7	Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line. (19141292)	Mikami Y.... Katsuki H.	2009	HIF1A, MUC1
8	Chemosensitivity of radioresistant cells in the multi cellular spheroids of A549 lung adenocarcinoma. (19490637)	Shi D.... Lartigau E.	2009	ABCC1
9	Effects of hydroquinone on expression of human 8-oxo -guanine DNA glycosylase mRNA in human A549 lung adenocarcinoma cell strains (19535000)	Shu Y.... Zhang Z.Z.	2009	OGG1
10	Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma. (20003463)	Yin Z.... Li X.	2009	ERCC2, ERCC1, XRCC1
11	Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma. (19308293)	Seder C.W.... Beer D.G.	2009	INHBA
12	Comparison of FISH, PCR, and immunohistochemistry in assessing EGFR status in lung adenocarcinoma and correlation with clinicopathol ogic features. (19704257)	El-Zammar O.A.... Katzenstein A.L.	2009	EGFR
13	Targeted reduction of KLF6-SV1 restores chemotherapy sensitivity in resistant lung adenocarcinoma. (19328586)	Sangodkar J.... Narla G.	2009	KLF6
14	Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: identification of the c-myc regulatory gene network. (18498649)	Reymann S.... Borlak J.	2008	SOX4
15	Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung adenocarcinoma. (18303429)	Marks J.L.... Pao W.	2008	EGFR, KRAS
16	Chromosomal changes in high- and low-invasive mouse lung adenocarcinoma cell strains derived from early passage mouse lung adenocarcinoma cell strains. (18367224)	Sargent L.M.... Reynolds S.H.	2008	TSN, NUCKS1
17	Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma. (19010870)	Bean J.... Pao W.	2008	EGFR
18	Cloning of novel tumor metastasis-related genes from the highly metastatic human lung adenocarcinoma cell line Anip973. (17498616)	Liu F.... Li P.	2007	RPL23
19	Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma. (17967182)	Tsou J.A.... Laird-Offringa I.A.	2007	CDKN2A, RASSF1, CDH13
20	Expression profile of heat shock proteins in tissues and cells of lung adenocarcinoma (17767061)	Liu X.L.... Hu C.H.	2007	HSPA4
21	Mutational analysis in cytological specimens of advanced lung adenocarcinoma: a sensitive method for molecular diagnosis. (18090579)	Boldrini L.... Fontanini G.	2007	EGFR, KRAS
22	Selected flavonoids potentiate the toxicity of cisplatin in human lung adenocarcinoma cells: a role for glutathione depletion. (17549417)	Kachadourian R.... Day B.J.	2007	CYCS, NDUFS4
23	Identification of DR9-restricted XAGE antigen on lung adenocarcinoma recognized by autologous CD4 T-cells. (17332921)	Shimono M.... Nakayama E.	2007	XAGE1D, XAGE1C, XAGE1A
24	Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells. (16632868)	Tong M.... Tai H.H.	2006	PTGS2, HPGD
25	Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor kappaB1 and mitogen-activated protein kinase pathways. (16911524)	SchAofer R.... Reiser G.	2006	MAPK14
26	CA125 cytosolic levels in lung adenocarcinomas. New biological aspects (15701343)	Ruibal A.... Rodriguez J.	2005	MUC16
27	NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways. (15949588)	Schuller H.M.... Cekanova M.	2005	RAF1, ADRB2, CREB1
28	Possible mechanism of metastasis in lung adenocarcinomas with a micropapillary pattern. (15982217)	Miyoshi T.... Nabeshima K.	2005	IQGAP1
29	Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism. (15688187)	Kikuchi A.... Sasaki H.	2005	HMOX1
30	Establishment of an immortalized cell line from a precancerous lesion of lung adenocarcinoma, and genes highly expressed in the early stages of lung adenocarcinoma development. (16232198)	Shimada A.... Noguchi M.	2005	S100A2, TACSTD2
31	Plutonium targets the p16 gene for inactivation by promoter hypermethylation in human lung adenocarcinoma. (14742312)	Belinsky S.A.... Telnov V.	2004	CDKN2A, MGMT, RASSF1
32	Effects of thalidomide on the expression of angiogenesis growth factors in human A549 lung adenocarcinoma cells. (12736723)	Li X.... Li Q.Q.	2003	FGF2, VEGFA
33	Sensitization to the cytotoxicity of cisplatin by transfection with nucleotide excision repair gene xeroderma pigmentosun group A antisense RNA in human lung adenocarcinoma cells. (14676109)	Wu X.... Zhou Y.	2003	XPA
34	Inactivation of O6-methylguanine-DNA methyltransferase in human lung adenocarcinoma relates to high-grade histology and worse prognosis among smokers. (11856482)	Hayashi H.... Kitamura H.	2002	MGMT
35	Effects of ectogenous FHIT gene on reversing malignant phenotype of human lung adenocarcinoma cells A549 (12048684)	Wang Y.... Yang Y.	2002	FHIT
36	Novel candidate tumor marker genes for lung adenocarcinoma. (12386823)	Wang K.K.... Tsao M.S.	2002	ITGA11, COL11A1, HABP2
37	Thymidine phosphorylase and vascular endothelial growth factor in patients with Stage I lung adenocarcinoma. (11920479)	Kojima H.... Abe S.	2002	VEGFA, TYMP
38	Clinicopathologic relevance of apoptotic and proliferative factors in human lung adenocarcinoma: Fas expression correlates with the histologic subtype, but not with the degree of apoptosis. (12498219)	Mojtahedzadeh S.... Sueishi K.	2002	FAS
39	Protection by quercetin against cooking oil fumes-induced DNA damage in human lung adenocarcinoma CL-3 cells: role of COX-2. (12672646)	Lin S.Y.... Lee H.	2002	PTGS2
40	Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma. (11170292)	Sunaga N.... Yokota J.	2001	APC, CTNNB1, AXIN1
41	Mucinous bronchioloalveolar carcinomas display a specific pattern of mucin gene expression among primary lung adenocarcinomas. (11274635)	Copin M.C.... Porchet N.	2001	MUC1, MUC4, MUC6
42	omega-hydroxylation activity toward leukotriene B(4) and polyunsaturated fatty acids in the human hepatoblastoma cell line, HepG2, and human lung adenocarcinoma cell line, A549. (11056396)	Yamane M.... Abe A.	2000	CYP4F2
43	Trichostatin A modulates expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells. (10746741)	Eickhoff B.... Van der Bosch J.	2000	BCL2L1
44	Effect of exogenous p16 gene on the growth of wild-type p53 human lung adenocarcinoma cells (11776846)	Fu X.... Ran R.	1999	TP53, CDKN2A
45	Differential response to benzo[A]pyrene in human lung adenocarcinoma cell lines: the absence of aryl hydrocarbon receptor activation. (10503953)	Chang K.W.... Lin P.	1999	CYP1A1, AHR
46	Molecular marker as an indicator in presaging prognosis of human lung adenocarcinoma (10322679)	Zhou B.... He A.	1998	PCNA, CDKN1A
47	Serum level and tissue expression of c-erbB-2 protein in lung adenocarcinoma. (7606952)	Osaki T.... Yasumoto K.	1995	ERBB2
48	The relationship between the immunodetection of transforming growth factor-beta in lung adenocarcinoma and longer survival rates. (7780613)	Inoue T.... Sugimachi K.	1995	BMP6
49	Immunohistochemical analysis of nm23/NDP kinase expression in human lung adenocarcinoma: association with tumor progression in Clara cell type. (7928630)	Ozeki Y.... Mamiya G.	1994	NME1
50	Simultaneous detection of intercellular adhesion molecule-1 (CD54) and carcinoembryonic antigen in lung adenocarcinoma. (7911996)	Nonomura A.... Takashima T.	1994	ICAM1, CEACAM7

Genes related to lung adenocarcinoma according to GeneCards:

(show top 50)    (show all 542)

id	Symbol	Description	Score	GeneCards Section Context
1	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	11.1	Publications, Summaries
2	MALAT1	metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)	11.0	Publications, Aliases & Descriptions, Orthologs
3	FAM57A	family with sequence similarity 57, member A	11.0	Aliases & Descriptions
4	LOC100996467	metastasis-associated lung adenocarcinoma transcript 1-like	11.0	Aliases & Descriptions
5	MIR182	microRNA 182	10.9	Publications
6	XAGE1D	X antigen family, member 1D	10.9	Publications
7	XAGE1C	X antigen family, member 1C	10.9	Publications
8	XAGE1E	X antigen family, member 1E	10.9	Publications
9	MIR145	microRNA 145	10.9	Publications
10	XAGE1A	X antigen family, member 1A	10.9	Publications
11	XAGE1B	X antigen family, member 1B	10.9	Publications
12	MIR200A	microRNA 200a	10.9	Publications
13	EIF4EBP3	eukaryotic translation initiation factor 4E binding protein 3	10.9	Publications
14	PRR13	proline rich 13	10.9	Publications
15	VCX	variable charge, X-linked	10.9	Publications
16	CXorf61	chromosome X open reading frame 61	10.9	Publications
17	NAPSA	napsin A aspartic peptidase	10.9	Publications
18	SCLY	selenocysteine lyase	10.9	Publications
19	NKX2-1	NK2 homeobox 1	10.9	Publications
20	ABHD11	abhydrolase domain containing 11	10.9	Publications
21	SEPHS2	selenophosphate synthetase 2	10.9	Publications
22	DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	10.9	Publications, Functions
23	HOXB2	homeobox B2	10.9	Publications
24	CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7	10.9	Publications
25	KLK13	kallikrein-related peptidase 13	10.9	Publications
26	MMRN2	multimerin 2	10.9	Publications
27	BHLHE41	basic helix-loop-helix family, member e41	10.9	Publications
28	CDK5RAP3	CDK5 regulatory subunit associated protein 3	10.9	Publications
29	NDUFA13	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13	10.9	Publications
30	LRG1	leucine-rich alpha-2-glycoprotein 1	10.9	Publications
31	WFDC2	WAP four-disulfide core domain 2	10.9	Publications
32	RIN1	Ras and Rab interactor 1	10.9	Publications
33	C19orf48	chromosome 19 open reading frame 48	10.9	Publications
34	MYCL1	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)	10.9	Publications
35	HRSP12	heat-responsive protein 12	10.9	Publications
36	TACSTD2	tumor-associated calcium signal transducer 2	10.9	Publications
37	ING4	inhibitor of growth family, member 4	10.9	Publications
38	ULBP1	UL16 binding protein 1	10.9	Publications
39	TSN	translin	10.9	Publications
40	SELENBP1	selenium binding protein 1	10.9	Publications, Expressions
41	S100P	S100 calcium binding protein P	10.9	Publications
42	SUPT7L	suppressor of Ty 7 (S. cerevisiae)-like	10.9	Publications
43	EMX2	empty spiracles homeobox 2	10.9	Publications
44	S100A2	S100 calcium binding protein A2	10.9	Publications
45	MEST	mesoderm specific transcript homolog (mouse)	10.9	Publications
46	NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1	10.9	Publications
47	UCN3	urocortin 3 (stresscopin)	10.9	Publications
48	CLIC1	chloride intracellular channel 1	10.9	Publications
49	DHDH	dihydrodiol dehydrogenase (dimeric)	10.9	Publications
50	NDN	necdin homolog (mouse)	10.9	Publications

Pathways related to lung adenocarcinoma according to GeneDecks:

(show top 50)    (show all 331)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and Autophagy3	12.3	SERPINB5, MYC, BID, BIRC2, BIRC5, PARP1
2	Cell Cycle / Checkpoint Control3	12.2	PCNA, RB1, XRCC1, CDK6, CDKN1A, CDK9
3	FAK1 Signaling36	12.0	BRAF, VCL, RAF1, RAC1, BCAR1, LAMA3
4	Breast Cancer Regulation by Stathmin136	11.9	VEGFB, RAF1, RAC1, AXL, FIGF, FGF2
5	Focal adhesion20	11.8	PIK3CA, PIK3CG, VWF, BRAF, VEGFB, VEGFC
6	ERK Signaling36	11.4	PIP, BRAF, VEGFB, VEGFC, MYC, BMP6
7	UPA-UPAR Pathway36	11.4	LAMA3, LAMA4, LAMC2, JUN, ITGA11, ITGAL
8	Paxillin Interactions36	11.4	VEGFB, VEGFC, VCL, RAC1, BDNF, KDR
9	Endometrial cancer20	11.4	PIK3CA, PIK3CG, BRAF, MYC, RAF1, AXIN1
10	Apoptosis and survival Role of CDK5 in neuronal death and survival10	11.1	BCL2, BAD, CASP9, ERBB3, CYCS, NTRK1
11	TRKA Signaling36	11.0	BRAF, MYC, RAF1, RAC1, BAX, JUN
12	Renal cell carcinoma20	11.0	RAF1, RAC1, JUN, FIGF, MET, MAPK3
13	Translation _Regulation of EIF4F activity41	11.0	PIK3CA, RAC1, MTOR, MAPK3, MAPK14, MAPK1
14	Endothelin-1 Signaling Pathway36	11.0	PIP, BRAF, MYC, BMP6, RAF1, AXL
15	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR110	11.0	MAP3K5
16	Ceramide Pathway36	11.0	RAF1, BAD, CERK, JUN, FOS, FADD
17	Antioxidant Action of Vitamin-C36	10.9	PIP, VEGFB, VEGFC, BMP6, RAC1, BDNF
18	Germ Cell-Sertoli Cell Junction Dynamics36	10.9	VCL, RAC1, BCAR1, AXIN1, CDH2, ITGB1
19	Pancreatic cancer20	10.9	CDK6
20	Actin-Based Motility by Rho Family GTPases36	10.9	BDNF, ITGA11, ITGAL, ITGB4, AREG, FGFR4
21	Glioma20	10.9	PIK3CA, PIK3CG, RB1, BRAF, RAF1, MTOR
22	Akt Signaling36	10.8	PIP, PIK3CG, VEGFB, VEGFC, RAF1, AXL
23	Development_Ligand-independent activation of ESR1 and ESR241	10.7	PIK3CA, RAF1, MAPK3, MAP2K1, CCND1, IGF1
24	Cellular Apoptosis Pathway36	10.7	VEGFB, VEGFC, BMP6, BID, BIRC2, BDNF
25	Signal transduction AKT signaling10	10.6	GSK3B, PPP2CA, PDPK1
26	Colorectal cancer20	10.5	PIK3CG, BRAF, RAC1, BAD, AXIN1, FOS
27	Development Neurotrophin family signaling10	10.5	PIK3CA, BRAF, RAF1, RAC1, BDNF, BAX
28	Development_ERBB-family signaling41	10.5	PIK3CA, RAF1, FOS, AREG, MAPK3, MAPK1
29	Development Thrombopoietin-regulated cell processes10	10.5	PIK3CA, BRAF, MYC, RAF1, RAC1, BIRC5
30	Development_HGF signaling pathway41	10.4	PIK3CA, RAF1, RAC1, JUN, CDH1, FOS
31	Rac1 Pathway36	10.3	VEGFB, BMP6, RAF1, RAC1, BDNF, KDR
32	Transcription_Androgen Receptor nuclear signaling41	10.3	RAF1, RAD9A, CDKN1A, MMP2, GSK3B, IL6
33	Cell cycle ESR1 regulation of G1/S transition10	10.3	RB1, RBL2, MYC, JUN, CDK6, CDKN1A
34	Nuclear Receptor Activation by Vitamin-A36	10.2	VEGFB, VEGFC, BMP6, RARB, BDNF, KDR
35	Transcription Receptor-mediated HIF regulation10	10.1	RAF1, INS, MAPK3, MAPK1, MAP2K1, IGF1R
36	Development_VEGF signaling via VEGFR2 - generic cascades41	10.1	PIK3CA, VEGFA, VCL, RAF1, RAC1, JUN
37	Apoptotic Pathways in Synovial Fibroblasts36	10.1	VEGFB, VEGFC, BMP6, BDNF, KDR, CFLAR
38	cAMP Pathway36	10.0	BRAF, VEGFB, VEGFC, BMP6, RAF1, CLIC1
39	Intracellular Calcium Signaling36	10.0	VEGFB, VEGFC, BMP6, BDNF, KDR, AXL
40	MAPK Family Pathway36	10.0	BRAF, VEGFB, VEGFC, BMP6, RAF1, RAC1
41	Cell cycle Regulation of G1/S transition (part 2)10	10.0	RB1, RBL2, JUN, CDK6, CDK2, CDK4
42	Prostate cancer20	9.9	PIK3CA, PIK3CG, RB1, BRAF, RAF1, BCL2
43	CDC42 Pathway36	9.9	RAF1, KDR, AXL, JUN, CDH1, ITGA11
44	PPAR Pathway36	9.8	VEGFB, VEGFC, RAF1, ITGA11, ITGAL, ITGB1
45	Immune response Oncostatin M signaling via MAPK in human cells10	9.7	RAF1, RAC1, LDLR, JUN, MMP1, FOS
46	Cyclins and Cell Cycle Regulation36	9.7	RB1, RAF1, CDK6, CDKN1A, CDK2, CDKN1B
47	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	9.5	MYC, RAF1, BCL2, BAX, JUN, FOS
48	JAK-STAT Pathway36	9.3	VEGFB, VEGFC, MYC, BMP6, RAF1, BDNF
49	Estrogen Pathway36	9.2	BRAF, VEGFB, VEGFC, BMP6, RAF1, BDNF
50	Immune response_MIF-mediated glucocorticoid regulation41	9.0	JUN, MMP1, FOS, MIF, IL2, IL6

Compounds related to lung adenocarcinoma according to GeneDecks:

(show top 50)    (show all 462)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	23.7	LRP1, VWF, RDX, SFTPB, SFTPC, SFTPD
2	cysteine32	16.5	LRP1, SFTPB, SFTPC, SFTPD, PCNA, SERPINA1
3	atp32	16.3	PIK3CA, SFTPB, RB1, RBL2, SETD2, SEPHS1
4	glucose32	14.5	SETD2, BRAF, VEGFC, VCL, BID, CISH
5	cholesterol32 9 18 9	16.7	PIK3CA, LRP1, VWF, SFTPB, SFTPC, SFTPD
6	hydrogen32 18	14.6	SFTPB, SFTPC, RAC1, BDNF, BCAR1, BCR
7	glyceraldehyde 3-phosphate32	13.4	SETD2, VEGFC, BIRC5, CLU, S100A9, CEACAM5
8	dexamethasone32 42 34 9 9	16.9	PIK3CA, LRP1, VWF, SFTPB, SFTPC, SFTPD
9	b 72332	12.8	PIP, PCNA, VIM, CHKA, MUC1, MUC16
10	gtp32	12.7	PIK3CA, RDX, BRAF, RAF1, RAC1, BCR
11	forskolin32 42 9 9	15.4	VIM, BRAF, BMP6, RARB, RAF1, RAC1
12	12-o-tetradecanoylphorbol 13-acetate32	12.3	SFTPB, RB1, BRAF, VCL, MYC, BMP6
13	hematoxylin32	12.3	PCNA, VIM, CHKA, MUC1, MUC16, MUC2
14	paclitaxel32 34 9 9	15.2	PIK3CA, PIK3CG, PCNA, RB1, SETD2, VIM
15	mucicarmine32	12.1	PIP, VIM, MUC1, S100A1, S100B, CEACAM5
16	heparin32 9 18 9	15.0	PIK3CA, PIK3CG, LRP1, VWF, SERPINA1, SERPINA3
17	phosphotyrosine32	11.9	PIK3CA, PIK3CG, RDX, RAF1, RAC1, KDR
18	guanine32 9 18 9	14.9	VWF, SELE, SETD2, LPL, RAF1, RAC1
19	agarose32	11.9	VWF, SFTPD, SERPINA1, MYC, BIRC2, CLU
20	camptothecin32 42 9 9	14.8	PIK3CG, PCNA, RB1, SETD2, MYC, BID
21	folate32	11.7	VWF, SELE, SERPINA3, VIM, MYC, RASSF1
22	erlotinib32 34 9 9	14.7	PIK3CA, VEGFA, BIRC5, KDR, MTOR, CDKN1B
23	ionomycin32	11.7	SETD2, SERPINA3, CDK6, CDK4, FOS, IL12RB1
24	sphingosine32 9 18 9	14.6	VIM, BCL2L1, UGCG, CERK, ITGAL, FAS
25	mitomycin c32	11.5	VWF, PCNA, RB1, BIRC5, MVP, XPA
26	crcs32	11.4	PIK3CA, RB1, BRAF, RASSF1, BIRC5, MUC1
27	pge132	11.3	VWF, CD9, MMP1, IL11, MAPK3, F2R
28	carbon32	11.3	VWF, SFTPD, PCNA, LPL, SCD, LDLR
29	citrate32	11.3	CHKA, MKI67, FGF2, FABP3, F8, AMPD3
30	docetaxel32 34 9 9	14.1	SETD2, VEGFA, MYC, RAF1, BID, BIRC2
31	1,25 dihydroxy vitamin d332	11.1	RB1, MYC, BMP6, RAF1, CLU, S100A9
32	vincristine32 34 9 9	13.9	UGCG, MLL, MGMT, FGF2, MAPK3, F8
33	pertussis32	10.9	PIK3CG, JUN, ITGAL, FOS, APC, MAPK1
34	k252a32	10.8	PIK3CG, VIM, BDNF, BCAR1, FGF2, MET
35	sulindac32 9 9	12.8	PCNA, BIRC5, BCL2, BCL2L1, BAX, CDKN1A
36	bcnu32	10.7	PARP1, CDKN2A, MGMT, GSTP1, GSTT1, IL2
37	cyclosporin a32 42	11.6	PIK3CA, PIK3CG, VWF, BSG, LPL, MYC
38	vitamin d32	10.3	LRP1, VIM, LPL, BMP6, RARB, CLU
39	go 697632 42	11.3	PIK3CG, CDK1, CDH1, MMP2, IL8, MAPK8
40	atorvastatin32 34 9 18 9	14.3	VWF, SELE, VEGFA, LPL, BMP6, RAC1
41	gw966232	10.1	BSG, RARB, BAX, CFLAR, MMP9, MAPK1
42	prostacyclin32	9.8	VWF, SELE, VEGFA, BMP6, KDR, LDLR
43	4-hydroxynonenal32 18	10.8	MYC, PARP1, CHKA, BAX, JUN, CDK2
44	losartan32 34 9 9	12.7	VWF, PCNA, SELE, BMP6, BDKRB2, MMP1
45	ns 39832 42	10.7	PIK3CG, PCNA, PARP1, CDKN1B, MMP1, FGF2
46	curcumin32	9.7	PIK3CG, VEGFA, MYC, RAF1, BID, BIRC2
47	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	9.6	PCNA, MYC, PARP1, BCL2, BCL2L1, BAK1
48	eb 108932	9.6	PCNA, CLU, PARP1, BCL2, BAX, CDK6
49	simvastatin32 34 42 9 18 9	14.5	VWF, SELE, VEGFA, LPL, BMP6, RAC1
50	pdtc32	8.9	PIK3CA, PIK3CG, SFTPB, SELE, SETD2, SERPINB5

Cellular components related to lung adenocarcinoma according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	15.4	PIK3CG, CNTN1, RDX, SELE, VIM, BSG
2	cytosol	GO:005829	14.7	PIK3CA, PIK3CG, NDN, SELENBP1, VIM, BRAF
3	integral to plasma membrane	GO:005887	13.2	LRMP, LRP1, CLDN4, CLDN1, BDKRB2, KDR
4	membrane	GO:016020	13.1	PIK3CG, LRG1, CNTN1, SEMA3C, SELENBP1, VEGFA
5	extracellular region	GO:005576	12.8	PIP, LRG1, VWF, SFTPD, SERPINA1, SERPINA3
6	nucleoplasm	GO:005654	12.5	PCNA, RB1, RBL2, MYC, RARB, RAD9A
7	extracellular space	GO:005615	12.3	LRG1, SFTPB, SFTPC, SFTPD, SELE, SEMA3C
8	platelet alpha granule lumen	GO:031093	10.5	VWF, SERPINA1, VEGFA, VEGFB, VEGFC, CLU
9	cell surface	GO:009986	10.1	VEGFA, LPL, LDLR, AXL, MSN, CDH1
10	caveola	GO:005901	9.9	SELE, CDH13, MAPK3, MAPK1, F2R, CAV1
11	Golgi lumen	GO:005796	9.9	MUC1, MUC16, MUC2, MUC3A, MUC4, MUC5AC
12	nucleus	GO:005634	INF	LRP1, KLF6, NDN, PCNA, RB1, RBL2
13	nucleolus	GO:005730	INF	RDX, PCNA, RBL2, SELENBP1, VCX, MYC
14	cytoplasm	GO:005737	INF	PIK3CG, LRP1, KLF6, PCNA, RBL2, SERPINB5

Biological processes related to lung adenocarcinoma according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell adhesion	GO:007155	13.2	CNTN1, VWF, VCL, RAC1, CLDN1, BCAR1
2	apoptotic process	GO:006915	12.9	VIM, RAF1, RAC1, BID, BIRC2, BIRC5
3	positive regulation of apoptotic process	GO:043065	12.4	RARB, RAD9A, BID, CLU, BCL2L11, BAD
4	signal transduction	GO:007165	12.4	VEGFC, RASSF8, RARB, RAF1, CLIC1, BCR
5	cell proliferation	GO:008283	12.3	PCNA, RAF1, BHLHE41, BCAR1, BCL2L1, BAK1
6	G1/S transition of mitotic cell cycle	GO:000082	12.1	PCNA, RB1, BCL2, UBC, CDK6, CDKN1A
7	response to lipopolysaccharide	GO:032496	11.9	SFTPB, SFTPC, SELE, SERPINA1, S100A8, S100A9
8	negative regulation of transcription from RNA polymerase II promoter	GO:000122	11.7	MYC, BMI1, RARB, BHLHE41, PARP1, SCGB1A1
9	cell cycle arrest	GO:007050	11.6	RB1, MYC, RASSF1, CDK6, CDKN1A, CDKN1B
10	cellular response to mechanical stimulus	GO:071260	11.6	SFTPB, SFTPC, BAD, BAK1, ITGB1, AQP1
11	induction of apoptosis by intracellular signals	GO:008629	11.5	MYC, BID, CLU, BCL2, BCL2L1, BCL2L11
12	induction of apoptosis	GO:006917	11.5	BCL2L11, BAD, BAX, CDKN1B, CDKN2A, ITM2B
13	virus-host interaction	GO:019048	11.4	RB1, VIM, CLDN1, KDR, LDLR, BAX
14	blood coagulation	GO:007596	11.4	PIK3CA, PIK3CG, VWF, SERPINA1, BSG, VEGFA
15	angiogenesis	GO:001525	11.4	PIK3CA, PIK3CG, SETD2, VEGFA, VEGFC, KDR
16	response to organic cyclic compound	GO:014070	11.3	SERPINA1, BAK1, JUN, CDKN1A, CDK1, MET
17	cellular component movement	GO:006928	11.3	SERPINB5, VIM, VCL, RAC1, MSN, CD9
18	activation of MAPKK activity	GO:000186	11.2	RAF1, MAP3K5, F2R, NTRK1, CRK, PSEN1
19	negative regulation of neuron apoptotic process	GO:043524	11.1	BRAF, VEGFB, BDNF, BCL2, BCL2L1, BAX
20	response to estradiol stimulus	GO:032355	11.1	SERPINA1, BID, MMP9, FOXA1, ANXA1, CCNE1
21	positive regulation of transcription from RNA polymerase II promoter	GO:045944	11.1	KLF6, RB1, VEGFA, MYC, BMP6, RARB
22	platelet activation	GO:030168	11.0	PIK3CA, PIK3CG, VWF, SERPINA1, VEGFA, VEGFB
23	release of cytochrome c from mitochondria	GO:001836	11.0	MYC, BID, CLU, BCL2, BCL2L1, BAK1
24	platelet degranulation	GO:002576	11.0	VWF, SERPINA1, VEGFA, VEGFB, VEGFC, VCL
25	fibroblast growth factor receptor signaling pathway	GO:008543	11.0	PIK3CA, BRAF, RAF1, UBC, BAD, MTOR
26	induction of apoptosis by extracellular signals	GO:008624	10.9	RAC1, BCL2L11, UBC, BAD, BAK1, BAX
27	aging	GO:007568	10.9	BAK1, JUN, IL15, FAS, CCL2, CCL5
28	response to hypoxia	GO:001666	10.8	SFTPB, SERPINA1, VEGFA, RAF1, BCL2, UCN3
29	nerve growth factor receptor signaling pathway	GO:048011	10.8	PIK3CA, NDN, BRAF, RAF1, RAC1, BCAR1
30	epidermal growth factor receptor signaling pathway	GO:007173	10.6	PIK3CA, RAF1, BCAR1, UBC, BAD, MTOR
31	inflammatory response	GO:006954	10.6	PIK3CG, SELE, SERPINA3, BMP6, RAC1, BDKRB2
32	Ras protein signal transduction	GO:007265	10.6	RB1, RAF1, RASSF1, CDKN1A, CDK2, CDKN2A
33	positive regulation of cell division	GO:051781	10.5	VEGFA, VEGFB, VEGFC, FIGF, FGF2, FGF9
34	positive regulation of cell proliferation	GO:008284	10.4	VEGFA, VEGFC, MYC, BIRC5, KDR, BCL2L1
35	positive regulation of transcription, DNA-dependent	GO:045893	10.4	KLF6, RB1, MYC, AXIN1, JUN, CDK2
36	positive regulation of MAPK cascade	GO:043410	10.4	KDR, CDH2, ITGB1, FLT1, FLT4, INS
37	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.4	MYC, BCL2L11, BAD, BAX, CDKN1B, CDKN2A
38	positive regulation of endothelial cell proliferation	GO:001938	10.3	VEGFA, VEGFB, BMP6, KDR, MTOR, JUN
39	anti-apoptosis	GO:006916	10.2	PIK3CA, BRAF, VEGFB, BIRC2, BIRC5, BDNF
40	negative regulation of apoptotic process	GO:043066	10.2	PIK3CG, BRAF, VEGFA, MYC, RAF1, BIRC2
41	phosphatidylinositol-mediated signaling	GO:048015	10.1	PIK3CA, PCNA, BAD, MTOR, CDKN1B, FOXO3
42	positive regulation of cell migration	GO:030335	10.0	VEGFA, KDR, BCAR1, CDH13, ITGB1, MMP14
43	response to drug	GO:042493	9.9	SEMA3C, VEGFC, LPL, MYC, BDKRB2, BDNF
44	heart development	GO:007507	9.8	PCNA, RAF1, ID3, CASP3, CASP8, GJA1
45	MAPK cascade	GO:000165	9.8	MYC, RAF1, CDK1, INS, MEN1, MAPK3
46	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.5	PIK3CA, BRAF, VEGFA, RAF1, BCL2, AXIN1
47	positive regulation of protein kinase B signaling cascade	GO:051897	9.4	PIK3CG, VEGFB, MTOR, AXL, INS, CCR7
48	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.4	KDR, FLT1, INS, CCL5, IGF1, F2
49	positive regulation of protein phosphorylation	GO:001934	9.3	VEGFA, MTOR, AXIN1, FLT4, MAPK3, CCND1
50	negative regulation of cell proliferation	GO:008285	INF	NDN, RARB, RAF1, BDKRB2, CIB1, BAK1

Molecular functions related to lung adenocarcinoma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:005524	12.9	NTRK1, NTRK2, NTRK3, PPP2R4, PDPK1, NDUFA13
2	protein homodimerization activity	GO:042803	12.2	VWF, SFTPC, VEGFA, VEGFB, BIRC5, BHLHE41
3	protein heterodimerization activity	GO:046982	11.9	TP53, ERBB2, ERBB3, MCL1, MET, INHBA
4	protein kinase binding	GO:019901	11.6	HSPB1, CCNB2, CCND1, CCNT1, CCNH, CCNE1
5	transcription factor binding	GO:008134	11.1	NR0B1, NFKBIA, HIF1A, AHR, TWIST1, TFDP1
6	identical protein binding	GO:042802	11.1	VIM, RAF1, RASSF1, BIRC5, CLDN4, CLDN1
7	enzyme binding	GO:019899	10.3	RAD9A, RAC1, BIRC5, AXIN1, PPARG, PLAUR
8	receptor binding	GO:005102	10.3	PPP2R4, SRC, TNFSF10, HNF4A, GJA1, CAV1
9	growth factor activity	GO:008083	10.1	INHBA, EGF, AGT, TYMP, TGFA, TGFB1
10	transcription regulatory region DNA binding	GO:044212	9.8	PPARG, NFKB1, WT1, HIF1A, AHR, TFAP2A
11	protein binding	GO:005515	INF	SLC9A1, HDAC9, E2F1, HGF, EPAS1, EPB41L3