MCID: LNG029
MIFTS: 42

Lung Adenocarcinoma malady

Summaries for Lung Adenocarcinoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Adenocarcinoma of the lung is a common histological form of lung cancer that contains certain distinct... more...

MalaCards: Lung Adenocarcinoma, also known as adenocarcinoma of lung, is related to adenocarcinoma and squamous cell carcinoma. An important gene associated with Lung Adenocarcinoma is KRAS (Kirsten rat sarcoma viral oncogene homolog), and among its related pathways is Dorso-ventral axis formation. The compounds mucicarmine and panitumumab have been mentioned in the context of this disorder.

Aliases & Classifications for Lung Adenocarcinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 61UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH, 40NCIt
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Aliases & Descriptions:

lung adenocarcinoma 8 43
adenocarcinoma of lung 8 43 61
non-small cell adenocarcinoma 61
nonsmall cell adenocarcinoma 8
adenocarcinoma lung 45


External Ids:

Disease Ontology8 DOID:3910
MeSH35 C538231
SNOMED-CT57 254626006
NCIt40 C3512

Related Diseases for Lung Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lung Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.3CEACAM7, KRAS, XAGE1D, FIGF, NKX2-1, EGFR
2squamous cell carcinoma30.8NKX2-1, S100A2, FIGF, KRAS, CEACAM7, EGFR
3colorectal cancer30.1KRAS, CEACAM7, FIGF, EGFR
4large cell carcinoma29.9KRAS, CEACAM7, EGFR, NKX2-1
5hypoxia10.5
6lung papillary adenocarcinoma10.4
7lung lymphoma10.3
8mucinous adenocarcinoma10.3
9adenoma10.3
10breast adenocarcinoma10.3
11thoracic cancer10.2
12obstructive jaundice10.2
13adenocarcinoma in situ10.2
14adenocarcinoma of lung, somatic10.2
15adenocarcinoma of lung, response to tyrosine kinase inhibitor in10.2
16neuroendocrine carcinoma10.1
17lung occult adenocarcinoma10.1
18lambert-eaton myasthenic syndrome10.1
19signet ring cell adenocarcinoma10.1
20xeroderma pigmentosum10.1
21actinomycosis10.1
22lung acinar adenocarcinoma10.1
23bronchogenic lung adenocarcinoma10.1
24adenoid cystic carcinoma10.1
25lung adenoid cystic carcinoma10.1
26lambert syndrome10.1
27paraneoplastic syndromes10.1
28xeroderma pigmentosum, group a10.1
29xeroderma pigmentosum, group g10.1
30rhabdoid tumor10.0
31melanoma10.0S100A2, NKX2-1, FIGF, XAGE1D, KRAS, CEACAM7
32prostate cancer10.0S100A2, EGFR, FIGF, XAGE1D, KRAS
33lung small cell carcinoma10.0CEACAM7, XAGE1D, NKX2-1, EGFR, KRAS
34lung cancer10.0NAPSA, CEACAM7, KRAS, NKX2-1, EGFR
35ovarian cancer10.0EGFR, NKX2-1, KRAS, FIGF, CEACAM7
36endometrial carcinoma10.0NKX2-1, EGFR, KRAS, FIGF, CEACAM7
37breast cancer10.0CEACAM7, KRAS, FIGF, EGFR, NKX2-1
38stomach cancer10.0FIGF, KRAS, EGFR, CEACAM7
39bronchiolo-alveolar adenocarcinoma10.0EGFR, KRAS, NKX2-1
40adenosquamous carcinoma10.0NKX2-1, EGFR, CEACAM7
41kidney cancer10.0NKX2-1, EGFR, FIGF, NAPSA
42cervical cancer10.0EGFR, KRAS, CEACAM7
43gastric adenocarcinoma10.0FIGF, KRAS, CEACAM7
44colon cancer10.0KRAS, EGFR, FIGF, CEACAM7
45non-small cell lung carcinoma10.0KRAS, NKX2-1, EGFR
46sarcoma10.0KRAS
47pulmonary blastoma10.0NKX2-1
48inflammatory breast carcinoma10.0EGFR, FIGF
49malignant mesothelioma10.0NKX2-1
50hemangioma10.0NKX2-1

Graphical network of the top 20 diseases related to Lung Adenocarcinoma:



Diseases related to lung adenocarcinoma

Clinical Features for Lung Adenocarcinoma

Drugs & Therapeutics for Lung Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Lung Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Lung Adenocarcinoma

Search NIH Clinical Center for Lung Adenocarcinoma

Search CenterWatch for Lung Adenocarcinoma

Genetic Tests for Lung Adenocarcinoma

Anatomical Context for Lung Adenocarcinoma

Animal Models for Lung Adenocarcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Lung Adenocarcinoma

Sources:
51PubMed
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Articles related to Lung Adenocarcinoma:

(show top 50)    (show all 1815)
idTitleAuthorsYear
1
Clinical implications related to preoperative detection of stage IA lung adenocarcinoma. (23497951)
2013
2
Low papillary structures in lepidic lung adenocarcinoma: any relationship with micropapillary lung adenocarcinoma?--reply. (24157067)
2013
3
Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling. (23135908)
2013
4
Coexistence of acute miliary pulmonary tuberculosis and metastatic lung adenocarcinoma: a case report. (23833731)
2013
5
Upregulation of tissue factor by activated Stat3 contributes to malignant pleural effusion generation via enhancing tumor metastasis and vascular permeability in lung adenocarcinoma. (24086497)
2013
6
Lung adenocarcinoma metastasis to frontal sinus mimicking Pott's puffy tumor. (24220459)
2013
7
Epigenetic downregulation of RUNX3 by DNA methylation induces docetaxel chemoresistance in human lung adenocarcinoma cells by activation of the AKT pathway. (23892093)
2013
8
New monoallelic combination of KRAS gene mutations in codons 12 and 13 in the lung adenocarcinoma. (23729630)
2013
9
Allelotypes of lung adenocarcinomas featuring ALK fusion demonstrate fewer onco- and suppressor gene changes. (23289484)
2013
10
Low-LET proton irradiation of A549 non-small cell lung adenocarcinoma cells: dose response and RBE determination. (23336211)
2013
11
Loss of DBC2 expression is an early and progressive event in the development of lung adenocarcinoma. (22901165)
2012
12
Breast metastasis from lung adenocarcinoma diagnosed with fine needle aspiration cytology: a case report. (23390851)
2012
13
IMP3 can predict aggressive behaviour of lung adenocarcinoma. (23190601)
2012
14
Expression and prognostic significance of MAP4K4 in lung adenocarcinoma. (22824148)
2012
15
CBDCA + Pemetrexed + Bevacizumab and Its Maintenance Chemotherapy in a Case of Solitary Breast Metastasis from a Lung Adenocarcinoma Resistant to Gefitinib. (23139670)
2012
16
Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor I^2 expression. (21896780)
2011
17
The expression of Ki-67, but not proliferating cell nuclear antigen, predicts poor disease free survival in patients with adenocarcinoma of the lung. (22199292)
2011
18
Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung. (21466904)
2011
19
Clustered genomic alterations in chromosome 7p dictate outcomes and targeted treatment responses of lung adenocarcinoma with EGFR-activating mutations. (21810691)
2011
20
Comparable rate of EGFR kinase domain mutation in lung adenocarcinomas from Chinese male and female never-smokers. (20418893)
2010
21
Quantitative proteome analysis reveals annexin A3 as a novel biomarker in lung adenocarcinoma. (18798225)
2009
22
Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line. (19141292)
2009
23
Apoptosis induction in human lung adenocarcinoma cells by oil-soluble allyl sulfides: triggers, pathways, and modulators. (19197990)
2009
24
Chemosensitivity of radioresistant cells in the multicellular spheroids of A549 lung adenocarcinoma. (19490637)
2009
25
The presence of carboxypeptidase-M in tumour cells signifies epidermal growth factor receptor expression in lung adenocarcinomas: the coexistence predicts a poor prognosis regardless of EGFR levels. (17922141)
2008
26
EGFR mutations are more frequent in well-differentiated than in poor-differentiated lung adenocarcinomas. (18985444)
2008
27
Expression of multidrug-resistance-related proteins P-glycoprotein, glutathione-S-transferases, topoisomerase-II and lung resistance protein in primary gastric cardiac adenocarcinoma. (18443954)
2008
28
Hypoxia increases the motility of lung adenocarcinoma cell line A549 via activation of the epidermal growth factor receptor pathway. (17425591)
2007
29
The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma. (17409846)
2006
30
Pulmonary fibroblasts stimulate the proliferation of cell lines from human lung adenocarcinomas. (16926627)
2006
31
Lung adenocarcinoma global profiling identifies type II transforming growth factor-beta receptor as a repressor of invasiveness. (15976377)
2005
32
Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas. (16109772)
2005
33
Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas. (15815931)
2005
34
Molecular analysis of the TSC1 gene in adenocarcinoma of the lung. (15541811)
2004
35
The effects of S-phase kinase-associated protein 2 (SKP2) on cell cycle status, viability, and chemoresistance in A549 lung adenocarcinoma cells. (15700547)
2004
36
Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas. (12644570)
2003
37
Sequence analysis and expression study of BRI gene in two lung adenocarcinoma cell lines with different metastatic potential]. (12903036)
2003
38
Olmsted syndrome with squamous cell carcinoma of extremities and adenocarcinoma of the lung: failure to detect loricrin gene mutation. (14721769)
2003
39
Cyclooxygenase-2 inhibition decreases primary and metastatic tumor burden in a murine model of orthotopic lung adenocarcinoma. (14566258)
2003
40
Loss of heterozygosity on chromosomes 9q and 16p in atypical adenomatous hyperplasia concomitant with adenocarcinoma of the lung. (11696455)
2001
41
Expression of vascular endothelial growth factor receptor 3 in blood and lymphatic vessels of lung adenocarcinoma. (11276003)
2001
42
Activity of growth factors in the IL-6 group in the differentiation of human lung adenocarcinoma. (10732762)
2000
43
A new tumor-rejection antigen recognized by cytotoxic T lymphocytes infiltrating into a lung adenocarcinoma. (10987294)
2000
44
Interleukin-2 gene transduction into freshly isolated lung adenocarcinoma cells with adenoviral vectors. (8989990)
1997
45
Localized adenocarcinoma of the lung: oncogene expression of erbB-2 and p53 in 150 patients. (9816029)
1995
46
Immunohistochemical analysis of nm23/NDP kinase expression in human lung adenocarcinoma: association with tumor progression in Clara cell type. (7928630)
1994
47
Coexisting macrophage-associated fibrin formation and tumor cell urokinase in squamous cell and adenocarcinoma of the lung tissues. (1913476)
1991
48
Primary mucinous adenocarcinoma of the lung with signet-ring cells: a histochemical comparison with signet-ring cell carcinomas of other sites. (2478443)
1989
49
Generation of monoclonal antibodies against human lung squamous cell carcinoma and adenocarcinoma using mice rendered tolerant to normal human lung. (3731100)
1986
50
Vindesine in the treatment of squamous cell carcinoma (WHO I), adenocarcinoma (WHO III), and large cell carcinoma (WHO IV) of the lung. (6301122)
1982

Genetic Variations for Lung Adenocarcinoma

Expression for genes affiliated with Lung Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Adenocarcinoma

Search GEO for disease gene expression data for Lung Adenocarcinoma.

Pathways for genes affiliated with Lung Adenocarcinoma

Sources:
30KEGG
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Pathways related to Lung Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8KRAS, EGFR

Compounds for genes affiliated with Lung Adenocarcinoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank
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Compounds related to Lung Adenocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mucicarmine4510.8CEACAM7, NKX2-1
2panitumumab45 50 1112.7KRAS, EGFR
3gefitinib45 50 1112.6CEACAM7, KRAS, EGFR

GO Terms for genes affiliated with Lung Adenocarcinoma

Sources:
16Gene Ontology
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Biological processes related to Lung Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex cell migrationGO:02179510.8NKX2-1, EGFR

Products for genes affiliated with Lung Adenocarcinoma

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Sources for Lung Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet