MCID: LNG031
MIFTS: 46

Lung Benign Neoplasm

Categories: Genetic diseases, Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Benign Neoplasm

MalaCards integrated aliases for Lung Benign Neoplasm:

Name: Lung Benign Neoplasm 12 14
Lung Neoplasms 41 69
Tumor of the Lung 12
Lung Tumor 51

Classifications:



External Ids:

Disease Ontology 12 DOID:3683
MeSH 41 D008175
NCIt 46 C3200
SNOMED-CT 64 126713003
UMLS 69 C0024121

Summaries for Lung Benign Neoplasm

MalaCards based summary : Lung Benign Neoplasm, also known as lung neoplasms, is related to desmoplastic small round cell tumor and glomus tumor, and has symptoms including hemoptysis An important gene associated with Lung Benign Neoplasm is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Developmental Biology and Endometrial cancer. Affiliated tissues include lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Lung Benign Neoplasm

Diseases in the Lung Cancer family:

Lung Benign Neoplasm Lung Carcinoma in Situ

Diseases related to Lung Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 desmoplastic small round cell tumor 30.1 CHGA ENO2 SYP
2 glomus tumor 30.0 ENO2 SYP TP53
3 cystadenoma 29.6 CHGA KRT7 SYP
4 neuroendocrine tumor 29.5 CHGA ENO2 KRT7 NCAM1 NKX2-1 SYP
5 pulmonary sclerosing hemangioma 29.4 CHGA KRT7 NKX2-1 SYP
6 sclerosing hemangioma 29.3 CHGA ENO2 KRT7 NKX2-1 SYP
7 lung cancer 27.7 CADM1 CHGA EGFR ENO2 HRAS KRAS
8 small cell carcinoma 27.5 CHGA EGFR ENO2 KRT7 NCAM1 NKX2-1
9 hilar lung neoplasm 11.9
10 pleuropulmonary blastoma 10.7
11 lung acinar adenocarcinoma 10.5 KRT7 NKX2-1
12 hyperplastic polyposis syndrome 10.5 KRAS TP53
13 ovarian germ cell teratoma 10.5 KRT7 NKX2-1
14 malignant spiradenoma 10.5 KRT7 TP53
15 vulvar intraepithelial neoplasia 10.5 KRT7 TP53
16 intracranial primitive neuroectodermal tumor 10.5 CHGA ENO2
17 ovarian germ cell cancer 10.5 KRT7 NKX2-1
18 malignant sertoli cell tumor 10.5 ENO2 SYP
19 vaginal benign neoplasm 10.5 CHGA KRT7
20 vaginal adenoma 10.5 CHGA KRT7
21 sinonasal undifferentiated carcinoma 10.5 ENO2 SYP
22 female reproductive endometrioid cancer 10.5 KRT7 TP53
23 sigmoid neoplasm 10.5 HRAS KRAS
24 vaginal tubulovillous adenoma 10.4 CHGA KRT7
25 ureter small cell carcinoma 10.4 CHGA SYP
26 mutyh-associated polyposis 10.4 KRAS TP53
27 apocrine adenoma 10.4 HRAS KRAS
28 mucinous adenofibroma 10.4 KRT7 SYP
29 chromosome 14q11-q22 deletion syndrome 10.4 HRAS NKX2-1
30 anal canal adenocarcinoma 10.4 KRAS KRT7
31 periampullary adenoma 10.4 HRAS KRAS
32 papillary serous adenocarcinoma 10.4 KRT7 NKX2-1 TP53
33 eccrine sweat gland neoplasm 10.4 KRT7 TP53
34 olfactory groove meningioma 10.4 CHGA TP53
35 pancreatic somatostatinoma 10.4 ENO2 SYP
36 schimmelpenning-feuerstein-mims syndrome 10.4 HRAS KRAS
37 pseudomyxoma peritonei 10.4 KRAS KRT7 TP53
38 papillary tumor of the pineal region 10.4 ENO2 SYP
39 adenoma of the pancreas 10.4 CHGA SYP
40 ovarian clear cell carcinoma 10.4 KRAS KRT7 TP53
41 acinar cell cystadenocarcinoma 10.4 CHGA SYP
42 epithelioid malignant peripheral nerve sheath tumor 10.4 CHGA ENO2
43 spitz nevus 10.4 HRAS TP53
44 small intestine cancer 10.4 ENO2 KRAS KRT7
45 primary hepatic neuroendocrine carcinoma 10.4 CHGA SYP
46 ovarian carcinosarcoma 10.4 ENO2 SYP
47 malignant ectomesenchymoma 10.4 ENO2 HRAS
48 multiple mucosal neuroma 10.4 ENO2 NCAM1
49 ectomesenchymoma 10.3 ENO2 HRAS
50 blastoma 10.3 NKX2-1 SYP TP53

Graphical network of the top 20 diseases related to Lung Benign Neoplasm:



Diseases related to Lung Benign Neoplasm

Symptoms & Phenotypes for Lung Benign Neoplasm

UMLS symptoms related to Lung Benign Neoplasm:


hemoptysis

GenomeRNAi Phenotypes related to Lung Benign Neoplasm according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.8 HRAS KRAS NCAM1 EGFR
2 Decreased viability GR00106-A-0 9.8 KRAS
3 Decreased viability GR00221-A-1 9.8 KRAS EGFR HRAS
4 Decreased viability GR00221-A-2 9.8 KRAS HRAS
5 Decreased viability GR00221-A-3 9.8 HRAS
6 Decreased viability GR00221-A-4 9.8 EGFR
7 Decreased viability GR00301-A 9.8 KRAS
8 Decreased viability GR00381-A-1 9.8 KRAS
9 Increased cell migration GR00055-A-3 8.92 HRAS KRAS NCAM1 EGFR

MGI Mouse Phenotypes related to Lung Benign Neoplasm:

43 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.29 RARB NKX2-1 RAF1 NCAM1 TP53 SFTPC
2 growth/size/body region MP:0005378 10.26 NKX2-1 SCGB1A1 RAF1 RARB TP53 SFTPC
3 cellular MP:0005384 10.22 RARB NKX2-1 KRAS RAF1 KRT7 NCAM1
4 mortality/aging MP:0010768 10.2 RARB NKX2-1 KRAS RAF1 NCAM1 TP53
5 cardiovascular system MP:0005385 10.19 RARB NKX2-1 KRAS RAF1 TP53 SFTPC
6 endocrine/exocrine gland MP:0005379 10.19 NKX2-1 SCGB1A1 RAF1 RARB TP53 CHGA
7 nervous system MP:0003631 10.14 RARB NKX2-1 RAF1 NCAM1 TP53 SYP
8 craniofacial MP:0005382 10.05 RARB RAF1 TP53 HRAS EGFR KRAS
9 neoplasm MP:0002006 10.03 NKX2-1 SCGB1A1 RAF1 TP53 SFTPC HRAS
10 normal MP:0002873 10.02 NKX2-1 SCGB1A1 RAF1 RARB TP53 SYP
11 no phenotypic analysis MP:0003012 9.97 NKX2-1 RAF1 TP53 SFTPC CHGA HRAS
12 renal/urinary system MP:0005367 9.86 SCGB1A1 KRT7 RARB TP53 CHGA HRAS
13 reproductive system MP:0005389 9.76 RARB NKX2-1 KRAS TP53 SFTPC CHGA
14 respiratory system MP:0005388 9.65 SCGB1A1 RAF1 RARB NKX2-1 SFTPC TP53
15 vision/eye MP:0005391 9.17 RARB KRAS RAF1 NCAM1 TP53 SFTPC

Drugs & Therapeutics for Lung Benign Neoplasm

Genetic Tests for Lung Benign Neoplasm

Anatomical Context for Lung Benign Neoplasm

MalaCards organs/tissues related to Lung Benign Neoplasm:

38
Lung

Publications for Lung Benign Neoplasm

Articles related to Lung Benign Neoplasm:

(show all 27)
# Title Authors Year
1
Insulinoma-associated protein 1 is a sensitive and specific marker of neuroendocrine lung neoplasms in cytology specimens. ( 29360191 )
2018
2
Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA. ( 26374070 )
2015
3
Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene. ( 23703846 )
2014
4
Panhypopituitarism and lung neoplasm: A case study. ( 23769487 )
2013
5
GCDFP-15 positive and TTF-1 negative primary lung neoplasms: a tissue microarray study of 381 primary lung tumors. ( 19620839 )
2009
6
Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms. ( 18413732 )
2008
7
Primary pulmonary synovial sarcoma, a rare primary lung neoplasm: two case reports and review of the current literature. ( 18713096 )
2008
8
Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from Swiss (CD-1) male mice exposed transplacentally to AZT. ( 16395694 )
2007
9
Expression of matrix metalloproteinases 3, 10 and 11 (stromelysins 1, 2 and 3) and matrix metalloproteinase 7 (matrilysin) by cancer cells in non-small cell lung neoplasms. Clinicopathologic studies. ( 16506596 )
2006
10
Discrimination of human lung neoplasm from normal lung by two target genes. ( 15331390 )
2004
11
[Molecular targetting therapy for non-small-cell lung neoplasms with EGF-R inhibitors]. ( 12652739 )
2003
12
Lung neoplasm mimicking an acute lateral myocardial infarction. ( 14608295 )
2003
13
Intrathoracic desmoid tumor mimicking primary lung neoplasm. ( 11383835 )
2001
14
Tumor markers kinetic in malignant lung neoplasms. ( 10350122 )
1999
15
Glucose transporter expression in developing fetal lungs and lung neoplasms. ( 10425560 )
1999
16
Expression of gelatinase A, tissue inhibitor of metalloproteinases-2, matrilysin, and trypsin(ogen) in lung neoplasms: an immunohistochemical study. ( 9158711 )
1997
17
[Prognostic value of neuron enolase levels in serum of patients with lung neoplasms]. ( 8520560 )
1995
18
[Comparison of the degree of regression of small cell lung neoplasm in clinical-radiologic evaluation with levels of neuron specific enolase (NSE) in serum]. ( 8616474 )
1995
19
[Incidence of beta HCG elevation in serum of patients with small cell lung neoplasms and their prognosis]. ( 8616477 )
1995
20
Expression of epidermal growth factor receptor in plutonium-239-induced lung neoplasms in dogs. ( 1313613 )
1992
21
[Usefulness of simultaneous antigenic determination of carcinoembryonic antigen (CEA), ferritin and orosomucoid levels in diagnosis of lung neoplasms]. ( 1843646 )
1991
22
[Activity of angiotensin I converting enzyme in serum and bronchoalveolar lavage fluid of patients with sarcoidosis and lung neoplasms]. ( 1668848 )
1991
23
[Tumor markers. II. Their significance in the follow-up of patients after radical resection of lung neoplasms]. ( 2082204 )
1990
24
[Histochemical localization of glyco-conjugate and CEA-glycoprotein in human lung neoplasms]. ( 2249589 )
1990
25
Unusual primary lung neoplasms: spindle cell and undifferentiated lung carcinomas expressing only vimentin. ( 2247906 )
1990
26
[Tumor markers. I. Their significance in the preoperative assessment of lung neoplasms]. ( 1964495 )
1990
27
Cryofibrinogen in a case of lung neoplasm associated with thrombophlebitis migrans. ( 13250040 )
1955

Variations for Lung Benign Neoplasm

Expression for Lung Benign Neoplasm

Search GEO for disease gene expression data for Lung Benign Neoplasm.

Pathways for Lung Benign Neoplasm

Pathways related to Lung Benign Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.47 EGFR HRAS KRAS KRT7 NCAM1 RAF1
2
Show member pathways
13.03 EGFR HRAS KRAS RAF1 RARB TP53
3
Show member pathways
12.94 EGFR HRAS KRAS RAF1 TP53
4 12.76 EGFR HRAS KRAS RAF1 RARB TP53
5 12.74 EGFR HRAS KRAS RAF1 TP53
6
Show member pathways
12.64 EGFR HRAS KRAS RAF1 TP53
7
Show member pathways
12.64 EGFR HRAS KRAS RAF1 RARB TP53
8
Show member pathways
12.57 EGFR HRAS KRAS TP53
9 12.56 ENO2 NCAM1 NKX2-1 SYP
10
Show member pathways
12.54 HRAS KRAS RAF1 TP53
11
Show member pathways
12.54 EGFR HRAS KRAS RAF1 TP53
12 12.49 EGFR HRAS KRAS RAF1 TP53
13
Show member pathways
12.45 EGFR HRAS KRAS RAF1 TP53
14
Show member pathways
12.43 EGFR HRAS KRAS TP53
15
Show member pathways
12.42 EGFR HRAS KRAS RAF1 TP53
16
Show member pathways
12.41 EGFR HRAS KRAS RAF1 TP53
17
Show member pathways
12.39 EGFR HRAS KRAS RAF1
18
Show member pathways
12.36 HRAS KRAS RAF1 TP53
19
Show member pathways
12.35 EGFR HRAS KRAS RAF1
20
Show member pathways
12.25 HRAS KRAS RAF1 TP53
21
Show member pathways
12.22 EGFR HRAS KRAS RAF1
22
Show member pathways
12.19 EGFR HRAS KRAS RAF1 TP53
23 12.18 EGFR HRAS KRAS RAF1
24 12.18 EGFR HRAS KRAS RAF1 TP53
25
Show member pathways
12.17 HRAS KRAS RAF1 TP53
26 12.16 HRAS KRAS RAF1 TP53
27
Show member pathways
12.13 HRAS KRAS RAF1 TP53
28
Show member pathways
12.12 EGFR HRAS KRAS RAF1
29
Show member pathways
12.07 EGFR HRAS KRAS RAF1
30
Show member pathways
12.03 EGFR HRAS KRAS TP53
31
Show member pathways
12.02 EGFR HRAS KRAS RAF1 TP53
32 11.98 HRAS KRAS RAF1 TP53
33 11.97 HRAS KRAS TP53
34 11.96 HRAS KRAS RAF1
35 11.96 HRAS KRAS RAF1 TP53
36 11.95 HRAS KRAS RAF1
37
Show member pathways
11.93 EGFR HRAS KRAS
38 11.92 HRAS RAF1 TP53
39 11.88 EGFR HRAS KRAS RAF1 TP53
40
Show member pathways
11.85 EGFR HRAS KRAS
41 11.84 EGFR HRAS KRAS RAF1
42
Show member pathways
11.8 HRAS KRAS RAF1
43 11.78 KRAS RAF1 TP53
44 11.76 EGFR HRAS KRAS RAF1
45 11.7 EGFR HRAS KRAS RAF1 TP53
46 11.69 HRAS RAF1 TP53
47 11.68 HRAS KRAS TP53
48
Show member pathways
11.68 HRAS KRAS RAF1
49 11.64 HRAS KRAS RAF1
50
Show member pathways
11.6 EGFR HRAS RAF1

GO Terms for Lung Benign Neoplasm

Biological processes related to Lung Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.99 EGFR HRAS NKX2-1 RAF1 RARB TP53
2 wound healing GO:0042060 9.65 EGFR RAF1 TP53
3 axon guidance GO:0007411 9.62 HRAS KRAS NCAM1 NKX2-1
4 Ras protein signal transduction GO:0007265 9.61 HRAS KRAS TP53
5 positive regulation of MAP kinase activity GO:0043406 9.58 EGFR HRAS KRAS
6 positive regulation of protein phosphorylation GO:0001934 9.56 EGFR HRAS KRAS RAF1
7 epidermal growth factor receptor signaling pathway GO:0007173 9.54 EGFR HRAS KRAS
8 epithelial tube branching involved in lung morphogenesis GO:0060441 9.52 KRAS NKX2-1
9 cerebral cortex cell migration GO:0021795 9.49 EGFR NKX2-1
10 response to isolation stress GO:0035900 9.46 HRAS KRAS
11 MAPK cascade GO:0000165 9.35 EGFR HRAS KRAS NCAM1 RAF1
12 ERBB2 signaling pathway GO:0038128 9.33 EGFR HRAS KRAS
13 regulation of long-term neuronal synaptic plasticity GO:0048169 8.8 HRAS KRAS SYP

Sources for Lung Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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