MCID: LNG032
MIFTS: 72

Lung Cancer malady

Genetic diseases (common), Cancer diseases, Respiratory diseases categories

Summaries for Lung Cancer

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Sources:
9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Lung cancer is one of the most common cancers in the world. it is a leading cause of cancer death in men and women in the united states. cigarette smoking causes most lung cancers. the more cigarettes you smoke per day and the earlier you started smoking, the greater your risk of lung cancer. high levels of pollution, radiation and asbestos exposure may also increase risk. common symptoms of lung cancer include a cough that doesn't go away and gets worse over time constant chest pain coughing up blood shortness of breath, wheezing, or hoarseness repeated problems with pneumonia or bronchitis swelling of the neck and face loss of appetite or weight loss fatigue doctors diagnose lung cancer using a physical exam, imaging, and lab tests. treatment depends on the type, stage, and how advanced it is. treatments include surgery, chemotherapy, radiation therapy, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Lung Cancer, also known as carcinoma of lung, is related to adenocarcinoma and breast cancer. An important gene associated with Lung Cancer is CYP2A6 (cytochrome P450, family 2, subfamily A, polypeptide 6), and among its related pathways are Hepatitis C and MAPK targets/ Nuclear events mediated by MAP kinases. The compounds glutamate and panitumumab have been mentioned in the context of this disorder. Affiliated tissues include the lung, lung and endothelial.

Disease Ontology:9 A respiratory system cancer that is located in the lung.

CDC:4 Lung cancer is the leading cause of cancer death and the second most common cancer among both men and women in the United States.

Wikipedia:66 Lung cancer, also known as carcinoma of the lung or pulmonary carcinoma, is a malignant lung tumor... more...

Description from OMIM:48 614210,608935,612593,211980,612571

Aliases & Classifications for Lung Cancer

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Sources:
9Disease Ontology, 21GeneTests, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 28ICD9CM, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

lung cancer 9 48 11 35
carcinoma of lung 9 21 23 63
lung carcinoma 9 46
malignant neoplasm of lung 63
malignant neoplasms 63
cancer of lung 9
cancer lung 46


Related Diseases for Lung Cancer

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Lung Cancer family:

Lung Carcinoma in Situ Lung Benign Neoplasm
Lung Cancer, Egfr-Related Lung Cancer, Gstm1-Related

Diseases related to Lung Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 504)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.3CYP2A6, GNB2L1, BRAF, CADM1, GSTM1, RASSF1
2breast cancer31.0PPP2R1B, CYP2A6, GNB2L1, BRAF, CADM1, DLC1
3lung adenocarcinoma30.9BRAF, CADM1, GSTM1, RASSF1, EGFR
4non-small cell lung carcinoma30.9BRAF, GSTM1, RASSF1, EGFR
5colorectal cancer30.6PPP2R1B, CYP2A6, BRAF, GSTM1, RASSF1, EGFR
6esophageal cancer30.5EGFR, DLEC1
7ovarian cancer30.4PPP2R1B, BRAF, RASSF1, EGFR
8stomach cancer30.4CYP2A6, BRAF, CADM1, GSTM1, RASSF1, EGFR
9colon cancer30.1PPP2R1B, CYP2A6, BRAF, GSTM1, RASSF1, EGFR
10prostate cancer30.1GNB2L1, MAEA, DLC1, DLEC1, GSTM1, RASSF1
11thyroid cancer29.9RASSF1, GSTM1, BRAF
12hepatocellular carcinoma29.8PPP2R1B, CYP2A6, CADM1, DLC1, GSTM1, RASSF1
13endotheliitis11.0
14lung cancer susceptibility10.9
15neuronitis10.8
16hypoxia10.7
17asbestosis10.7
18silicosis10.7
19interstitial lung disease10.6
20lambert-eaton myasthenic syndrome10.6
21paraneoplastic syndromes10.6
22esophagitis10.6
23pneumonia10.5
24retinoblastoma10.5
25neutropenia10.5
26pulmonary fibrosis10.5
27tuberculosis10.5
28pulmonary function10.5
29idiopathic pulmonary fibrosis10.5
30leukemia10.5
31mediastinitis10.5
32melanoma10.4
33superior vena cava syndrome10.4
34thrombocytosis10.4
35pneumoconiosis10.4
36pulmonary tuberculosis10.4
37prostatitis10.4
38thyroiditis10.4
39pleurisy10.4
40blindness10.4
41small cell carcinoma10.3
42cryptococcosis10.3
43encephalitis10.3
44mutagen sensitivity10.3
45hypercalcemia10.3
46nicotine dependence10.3
47pancreatitis10.3
48limbic encephalitis10.3
49xeroderma pigmentosum10.3
50bronchogenic carcinoma10.3

Graphical network of the top 20 diseases related to Lung Cancer:



Diseases related to lung cancer

Symptoms for Lung Cancer

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Sources:
48OMIM
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Symptoms by clinical synopsis from OMIM:

211980

Clinical features from OMIM:

614210,608935,612593,211980,612571

Drugs & Therapeutics for Lung Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Lung Cancer

Drug clinical trials:

Search ClinicalTrials for Lung Cancer

Search NIH Clinical Center for Lung Cancer

Search CenterWatch for Lung Cancer

Genetic Tests for Lung Cancer

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Sources:
21GeneTests, 23GTR
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Genetic tests related to Lung Cancer:

id Genetic test Affiliating Genes
1 Lung Cancer21 23 GSTM1

Anatomical Context for Lung Cancer

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Lung Cancer:

34
Lung, Endothelial, Lymph node, Bone, Breast, Testes, Brain, T cells, Testis, Colon, Bone marrow, Monocytes, Prostate, Liver, Thyroid, Pituitary, Kidney, Bronchial epithelium, Nk cells, Placenta, Heart, Whole blood, Salivary gland, Small intestine, Skin, Tongue, Spinal cord, Myeloid, Skeletal muscle

FMA organs/tissues related to Lung Cancer:

15
The lung

Animal Models for Lung Cancer or affiliated genes

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Publications for Lung Cancer

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Sources:
53PubMed
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Articles related to Lung Cancer:

(show top 50)    (show all 9858)
idTitleAuthorsYear
1
Can statins reduce risk of lung cancer, especially among elderly people? A meta-analysis. (24385695)
2013
2
Relationship between gene polymorphisms of two cytokine genes (TNF-I+ and IL-6) and occurring of lung cancers in the ethnic group Han of China. (23100065)
2013
3
let-7b and miR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non--small--cell lung cancer. (23029111)
2012
4
Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data. (22418244)
2012
5
Relationship among the expression of lymphatic vessel density, microvessel density, carcinoembryonic antigenic mRNA, KAI1, and Kiss-1, and prognosis in patients with non-small cell lung cancer]. (22681921)
2012
6
Protein arginine methyltransferase 5 is essential for growth of lung cancer cells. (22708516)
2012
7
Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL- 1/4.1B). (21131357)
2011
8
Association of FOXP3 expression with non-small cell lung cancer. (21617226)
2011
9
P21 (waf1/cip1) is required for non-small cell lung cancer sensitive to Gefitinib treatment. (21616632)
2011
10
Single-agent gefitinib with concurrent radiotherapy for locally advanced non-small cell lung cancer harboring mutations of the epidermal growth factor receptor. (20828860)
2011
11
Expression and clinical relevance of uPA and ET-1 in non-small cell lung cancer]. (21219832)
2011
12
High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines. (20154083)
2010
13
XRCC1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis. (19329222)
2009
14
Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis and correlates with improved patient survival in non-small cell lung cancer. (19111386)
2009
15
Age-associated changes of extracellular matrix collagen impair lung cancer cell migration. (19109409)
2009
16
Association of XPD polymorphisms with severe toxicity in non-small cell lung cancer patients in a Chinese population. (19458053)
2009
17
Proteomics and pathway analysis identifies JNK signaling as critical for high linear energy transfer radiation-induced apoptosis in non-small lung cancer cells. (19168796)
2009
18
2008 Meeting of the National Lung Cancer Partnership: a summary of meeting highlights. (19395913)
2009
19
Association of DNA repair gene XRCC1 and lung cancer susceptibility among nonsmoking Chinese women. (19061777)
2009
20
Blazein of a new steroid isolated from Agaricus blazei Murrill (himematsutake) induces cell death and morphological change indicative of apoptotic chromatin condensation in human lung cancer LU99 and stomach cancer KATO III cells. (19020714)
2008
21
Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy. (18854777)
2008
22
Expression of cyclin D1 splice variants is differentially associated with outcome in non-small cell lung cancer patients. (18715616)
2008
23
Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer. (18212743)
2008
24
Mediastinal lymphatic drainage from pulmonary lobe based on CT observations of histoplasmosis: implications for minimal N2 disease of non-small-cell lung cancer. (17952543)
2007
25
Serum level changes of matrix metalloproteinases 2 and 9, vascular endothelial growth factor and epidermal growth factor receptor during platinum-based chemotherapy in advanced non-small cell lung cancer patients. (17436410)
2007
26
In vitro simulation study of individualized chemotherapy in lung cancer. (17625370)
2007
27
Hypoxia-inducible factor-1alpha suppressing apoptosis and increasing tolerance of lung cancer cells to chemotherapy. (17219956)
2006
28
Enhanced expression of VEGF following bFGF inhibition in non-small cell lung cancer cell lines. (16934908)
2006
29
Consequences of chemoresistance for the herpes simplex virus thymidine kinase/ganciclovir-induced bystander effect in a human small cell lung cancer cell line model. (15816546)
2005
30
Serum carcinoembryonic antigen level in pN1 non-small cell lung cancer patients. (16101187)
2005
31
Role of IL-6 in neuroendocrine differentiation and chemosensitivity of non-small cell lung cancer. (15894559)
2005
32
Cyclooxygenase-independent down-regulation of multidrug resistance-associated protein-1 expression by celecoxib in human lung cancer cells. (16170027)
2005
33
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. (15746151)
2005
34
Targeted radiotherapy for small cell lung cancer using 90Yttrium-DOTATOC, an Yttrium-labelled somatostatin analogue: a pilot trial. (15301877)
2004
35
Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study. (12660004)
2003
36
Induction of RECK by nonsteroidal anti-inflammatory drugs in lung cancer cells. (12447698)
2002
37
IL-12-induced production of IL-10 and interferon-gamma by mononuclear cells in lung cancer-associated malignant pleural effusions. (11804690)
2002
38
Gemcitabine and docetaxel every 2 weeks in advanced non-small cell lung cancer: a phase II study of the Gruppo Oncologico Italia Meridionale. (12367797)
2002
39
A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility. (11691799)
2001
40
Clinical significance of caspase-3 expression in pathologic-stage I, nonsmall-cell lung cancer. (11992386)
2001
41
p21 is associated with cyclin D1, p16INK4a and pRb expression in resectable non-small cell lung cancer. (10762631)
2000
42
Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy protection of the esophagus from chemoradiotherapy damage during treatment of locally unresectable non-small-cell lung cancer (NSCLC). (14733636)
2000
43
Evidence for a role of FGF-2 and FGF receptors in the proliferation of non-small cell lung cancer cells. (10495436)
1999
44
MUC1 (episialin) expression in non-small cell lung cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients. (9930070)
1998
45
72-kD (MMP-2) and 92-kD (MMP-9) type IV collagenase production and activity in different histologic types of lung cancer cells. (9577961)
1998
46
Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer. (9036871)
1997
47
Antitumor activity of a monoclonal antibody directed against gastrin-releasing peptide in patients with small cell lung cancer. (9228385)
1997
48
Phase I study of cisplatin, ifosfamide and CPT11 with granulocyte colony-stimulating factor support in advanced non-small cell lung cancer]. (8831740)
1996
49
Altered HLA class I expression in non-small cell lung cancer is independent of c-myc activation. (1849792)
1991
50
Epidemiologic and histologic observations on lung cancer in pneumoconiosis population. (7172143)
1982

Variations for Lung Cancer

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Lung Cancer:

65
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Clinvar genetic disease variations for Lung Cancer:

1
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> T (p.Gly12Cys)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
2FASLGNM_000639.1(FASLG): c.-844C=single nucleotide variantPathogenic, risk factorrs763110GRCh37Chr 1, 172627498: 172627498
3PPP2R1BNM_181699.2(PPP2R1B): c.269G> A (p.Gly90Asp)single nucleotide variantPathogenicrs1805076GRCh37Chr 11, 111635566: 111635566
4SLC22A18NM_183233.2(SLC22A18): c.698C> T (p.Ser233Phe)single nucleotide variantPathogenicrs121909071GRCh37Chr 11, 2939260: 2939260

Expression for genes affiliated with Lung Cancer

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Cancer

Search GEO for disease gene expression data for Lung Cancer.

Pathways for genes affiliated with Lung Cancer

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Sources:
51PathCards, 31KEGG, 56Reactome, 5Cell Signaling Technology, 61Thomson Reuters
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Compounds for genes affiliated with Lung Cancer

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR
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Compounds related to Lung Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glutamate4610.7ERCC6, ALDOA, BRAF, GNB2L1, CYP2A6
2panitumumab46 52 1212.6EGFR, BRAF
3cumene hydroperoxide4610.6GSTM1, CYP2A6
4phenobarbital46 30 52 1213.5GSTM1, CYP2A, CYP2A6
5debrisoquine46 5211.3CYP2A6, GSTM1

GO Terms for genes affiliated with Lung Cancer

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Sources:
17Gene Ontology
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Cellular components related to Lung Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.9SLC4A1AP, GNB2L1, DLC1, DLEC1, GSTM1, RASSF1

Biological processes related to Lung Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell migrationGO:03033510.6EGFR, GNB2L1, SPAG9

Molecular functions related to Lung Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9SPAG9, GNB2L1, BRAF, CADM1, ALDOA, DLC1
2enzyme bindingGO:01989910.3EGFR, GSTM1, GNB2L1, CYP2A6

Products for genes affiliated with Lung Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lung Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet