MCID: LNG032
MIFTS: 79

Lung Cancer malady

Genetic diseases (common), Cancer diseases, Respiratory diseases categories
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Summaries for Lung Cancer

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MedlinePlus:33 Lung cancer is one of the most common cancers in the world. it is a leading cause of cancer death in men and women in the united states. cigarette smoking causes most lung cancers. the more cigarettes you smoke per day and the earlier you started smoking, the greater your risk of lung cancer. high levels of pollution, radiation and asbestos exposure may also increase risk. common symptoms of lung cancer include a cough that doesn't go away and gets worse over time constant chest pain coughing up blood shortness of breath, wheezing, or hoarseness repeated problems with pneumonia or bronchitis swelling of the neck and face loss of appetite or weight loss fatigue doctors diagnose lung cancer using a physical exam, imaging, and lab tests. treatment depends on the type, stage, and how advanced it is. treatments include surgery, chemotherapy, radiation therapy, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards based summary: Lung Cancer, also known as cancer of lung, is related to adenocarcinoma and lung adenocarcinoma, and has symptoms including An important gene associated with Lung Cancer is CYP2A6 (cytochrome P450, family 2, subfamily A, polypeptide 6), and among its related pathways are Ras signaling pathway and Pathways in cancer. The compounds cisplatin and paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include the lung, lung and endothelial, and related mouse phenotypes are nervous system and tumorigenesis.

Disease Ontology:8 A respiratory system cancer that is located in the lung.

CDC:3 Lung cancer is the leading cause of cancer death and the second most common cancer among both men and women in the United States.

Wikipedia:65 Lung cancer, also known as carcinoma of the lung or pulmonary carcinoma, is a malignant lung tumor... more...

Descriptions from OMIM:46 612593,608935,614210,211980,612571

Aliases & Classifications for Lung Cancer

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Lung Cancer, Aliases & Descriptions:

Name: Lung Cancer 8 46 10 33
Cancer of Lung 8 20 22
Lung Carcinoma 8 44
Malignant Neoplasm of Lung 62
 
Malignant Neoplasms 62
Carcinoma of Lung 62
Cancer Lung 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases
Anatomical: Respiratory diseases


Related Diseases for Lung Cancer

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Diseases in the Lung Cancer family:

Lung Carcinoma in Situ Lung Benign Neoplasm
Lung Cancer, Egfr-Related Lung Cancer, Gstm1-Related

Diseases related to Lung Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 517)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.2CYP2A6, BRAF, FASLG, CADM1, GSTM1, RASSF1
2lung adenocarcinoma31.9BRAF, CADM1, GSTM1, RASSF1, KRAS, EGFR
3non-small cell lung carcinoma31.8CYP2A6, BRAF, CADM1, GSTM1, RASSF1, KRAS
4colorectal cancer31.6BRAF, FASLG, RASSF1, KRAS, EGFR
5breast cancer31.6EGFR, KRAS, RASSF1, DLEC1, PPP2R1B
6ovarian cancer31.4BRAF, FASLG, RASSF1, KRAS, EGFR
7adenoma31.3CYP2A6, BRAF, GSTM1, RASSF1, KRAS
8stomach cancer31.3BRAF, FASLG, RASSF1, KRAS, EGFR
9esophageal cancer31.3EGFR, DLEC1
10pancreatic cancer31.1BRAF, FASLG, CADM1, KRAS, EGFR
11lung small cell carcinoma31.0GSTM1, RASSF1, KRAS, EGFR
12malignant glioma30.8BRAF, FASLG, CADM1, RASSF1, EGFR
13seminoma30.8BRAF, RASSF1, KRAS
14endometrial carcinoma30.8BRAF, RASSF1, KRAS, EGFR
15oral cancer30.7FASLG, GSTM1, EGFR
16squamous cell carcinoma of the head and neck30.7EGFR, RASSF1, GSTM1
17myelodysplastic syndromes30.7FASLG, GSTM1, KRAS
18prostate cancer30.5FASLG, DLC1, DLEC1, GSTM1, RASSF1, KRAS
19endotheliitis11.0
20lung cancer susceptibility11.0
21neuronitis10.8
22hypoxia10.8
23tongue squamous cell carcinoma10.7CYP2A6, FASLG, CADM1, GSTM1, RASSF1, KRAS
24nasopharynx carcinoma10.7CYP2A6, CADM1, GSTM1, RASSF1, EGFR
25lung benign neoplasm10.7CYP2A6, CADM1, RASSF1, KRAS, EGFR
26asbestosis10.7
27bladder carcinoma10.7CYP2A6, GSTM1, RASSF1, KRAS, EGFR
28kidney cancer10.7BRAF, FASLG, ALDOA, RASSF1, EGFR
29silicosis10.7
30cervical cancer10.7CADM1, GSTM1, RASSF1, EGFR
31bladder carcinoma in situ10.7EGFR, RASSF1, GSTM1
32breast cancer, somatic10.6KRAS, SLC22A18
33coumarin resistance10.6CYP2A6
34cholangiocarcinoma10.6BRAF, RASSF1, KRAS
35interstitial lung disease10.6
36cardiofaciocutaneous syndrome10.6BRAF, KRAS
37oligodendroglioma10.6BRAF, EGFR
38lambert-eaton myasthenic syndrome10.6
39paraneoplastic syndromes10.6
40esophagitis10.6
41pneumonia10.6
42costello syndrome10.6BRAF, KRAS
43thyroid hurthle cell carcinoma10.6RASSF1, GSTM1, BRAF
44familial adenomatous polyposis10.6BRAF, RASSF1, KRAS
45pulmonary fibrosis10.5
46retinoblastoma10.5
47tuberculosis10.5
48pulmonary function10.5
49gastric adenocarcinoma10.5FASLG, GSTM1, KRAS
50dengue disease10.5KRAS, SPAG9

Graphical network of the top 20 diseases related to Lung Cancer:



Diseases related to lung cancer

Symptoms for Lung Cancer

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Symptoms by clinical synopsis from OMIM:

211980

Clinical features from OMIM:

612593,608935,614210,211980,612571

HPO human phenotypes related to Lung Cancer:

id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 alveolar cell carcinoma HP:0006519

Drugs & Therapeutics for Lung Cancer

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Drug clinical trials:

Search ClinicalTrials for Lung Cancer

Search NIH Clinical Center for Lung Cancer

Genetic Tests for Lung Cancer

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Genetic tests related to Lung Cancer:

id Genetic test Affiliating Genes
1 Lung Cancer20 22 GSTM1

Anatomical Context for Lung Cancer

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MalaCards organs/tissues related to Lung Cancer:

32
Lung, Endothelial, Lymph node, Bone, Breast, Testes, Brain, T cells, Colon, Testis, Bone marrow, Neutrophil, Prostate, Monocytes, Liver, Thyroid, Pituitary, Bronchial epithelium, Kidney, Heart, Placenta, Nk cells, Whole blood, Small intestine, Salivary gland, Skin, Spinal cord, Skeletal muscle, Myeloid, Tongue

FMA organs/tissues related to Lung Cancer:

14
The lung

Animal Models for Lung Cancer or affiliated genes

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MGI Mouse Phenotypes related to Lung Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.9FASLG, CADM1, DLC1, GSTM1, ERCC6, KRAS
2MP:000200610.9EGFR, KRAS, ERCC6, RASSF1, FASLG, BRAF
3MP:000287310.8BRAF, FASLG, CADM1, DLC1, RASSF1, KRAS
4MP:000538410.8BRAF, FASLG, DLC1, GSTM1, RASSF1, ERCC6
5MP:000118610.4SPAG9, BRAF, KRAS, EGFR

Publications for Lung Cancer

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Articles related to Lung Cancer:

(show top 50)    (show all 10270)
idTitleAuthorsYear
1
Can statins reduce risk of lung cancer, especially among elderly people? A meta-analysis. (24385695)
2013
2
Relationship between gene polymorphisms of two cytokine genes (TNF-I+ and IL-6) and occurring of lung cancers in the ethnic group Han of China. (23100065)
2013
3
Cytokeratin 19 fragment predicts the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitor in non-small-cell lung cancer harboring EGFR mutation. (23591159)
2013
4
let-7b and miR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non--small--cell lung cancer. (23029111)
2012
5
Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data. (22418244)
2012
6
Relationship among the expression of lymphatic vessel density, microvessel density, carcinoembryonic antigenic mRNA, KAI1, and Kiss-1, and prognosis in patients with non-small cell lung cancer]. (22681921)
2012
7
Protein arginine methyltransferase 5 is essential for growth of lung cancer cells. (22708516)
2012
8
Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL- 1/4.1B). (21131357)
2011
9
Association of FOXP3 expression with non-small cell lung cancer. (21617226)
2011
10
P21 (waf1/cip1) is required for non-small cell lung cancer sensitive to Gefitinib treatment. (21616632)
2011
11
Single-agent gefitinib with concurrent radiotherapy for locally advanced non-small cell lung cancer harboring mutations of the epidermal growth factor receptor. (20828860)
2011
12
Expression and clinical relevance of uPA and ET-1 in non-small cell lung cancer]. (21219832)
2011
13
High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines. (20154083)
2010
14
XRCC1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis. (19329222)
2009
15
Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis and correlates with improved patient survival in non-small cell lung cancer. (19111386)
2009
16
Age-associated changes of extracellular matrix collagen impair lung cancer cell migration. (19109409)
2009
17
Association of XPD polymorphisms with severe toxicity in non-small cell lung cancer patients in a Chinese population. (19458053)
2009
18
Proteomics and pathway analysis identifies JNK signaling as critical for high linear energy transfer radiation-induced apoptosis in non-small lung cancer cells. (19168796)
2009
19
2008 Meeting of the National Lung Cancer Partnership: a summary of meeting highlights. (19395913)
2009
20
Association of DNA repair gene XRCC1 and lung cancer susceptibility among nonsmoking Chinese women. (19061777)
2009
21
Blazein of a new steroid isolated from Agaricus blazei Murrill (himematsutake) induces cell death and morphological change indicative of apoptotic chromatin condensation in human lung cancer LU99 and stomach cancer KATO III cells. (19020714)
2008
22
Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy. (18854777)
2008
23
Expression of cyclin D1 splice variants is differentially associated with outcome in non-small cell lung cancer patients. (18715616)
2008
24
Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer. (18212743)
2008
25
Mediastinal lymphatic drainage from pulmonary lobe based on CT observations of histoplasmosis: implications for minimal N2 disease of non-small-cell lung cancer. (17952543)
2007
26
Serum level changes of matrix metalloproteinases 2 and 9, vascular endothelial growth factor and epidermal growth factor receptor during platinum-based chemotherapy in advanced non-small cell lung cancer patients. (17436410)
2007
27
In vitro simulation study of individualized chemotherapy in lung cancer. (17625370)
2007
28
Hypoxia-inducible factor-1alpha suppressing apoptosis and increasing tolerance of lung cancer cells to chemotherapy. (17219956)
2006
29
Enhanced expression of VEGF following bFGF inhibition in non-small cell lung cancer cell lines. (16934908)
2006
30
Consequences of chemoresistance for the herpes simplex virus thymidine kinase/ganciclovir-induced bystander effect in a human small cell lung cancer cell line model. (15816546)
2005
31
Serum carcinoembryonic antigen level in pN1 non-small cell lung cancer patients. (16101187)
2005
32
Role of IL-6 in neuroendocrine differentiation and chemosensitivity of non-small cell lung cancer. (15894559)
2005
33
Cyclooxygenase-independent down-regulation of multidrug resistance-associated protein-1 expression by celecoxib in human lung cancer cells. (16170027)
2005
34
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. (15746151)
2005
35
Targeted radiotherapy for small cell lung cancer using 90Yttrium-DOTATOC, an Yttrium-labelled somatostatin analogue: a pilot trial. (15301877)
2004
36
Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study. (12660004)
2003
37
Induction of RECK by nonsteroidal anti-inflammatory drugs in lung cancer cells. (12447698)
2002
38
Association of L-myc polymorphism with lung cancer susceptibility and prognosis in relation to age-selected controls and stratified cases. (11955646)
2002
39
IL-12-induced production of IL-10 and interferon-gamma by mononuclear cells in lung cancer-associated malignant pleural effusions. (11804690)
2002
40
A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility. (11691799)
2001
41
Clinical significance of caspase-3 expression in pathologic-stage I, nonsmall-cell lung cancer. (11992386)
2001
42
p21 is associated with cyclin D1, p16INK4a and pRb expression in resectable non-small cell lung cancer. (10762631)
2000
43
Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy protection of the esophagus from chemoradiotherapy damage during treatment of locally unresectable non-small-cell lung cancer (NSCLC). (14733636)
2000
44
Evidence for a role of FGF-2 and FGF receptors in the proliferation of non-small cell lung cancer cells. (10495436)
1999
45
MUC1 (episialin) expression in non-small cell lung cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients. (9930070)
1998
46
72-kD (MMP-2) and 92-kD (MMP-9) type IV collagenase production and activity in different histologic types of lung cancer cells. (9577961)
1998
47
Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer. (9036871)
1997
48
Antitumor activity of a monoclonal antibody directed against gastrin-releasing peptide in patients with small cell lung cancer. (9228385)
1997
49
Phase I study of cisplatin, ifosfamide and CPT11 with granulocyte colony-stimulating factor support in advanced non-small cell lung cancer]. (8831740)
1996
50
Epidemiologic and histologic observations on lung cancer in pneumoconiosis population. (7172143)
1982

Variations for Lung Cancer

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UniProtKB/Swiss-Prot genetic disease variations for Lung Cancer:

64
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Clinvar genetic disease variations for Lung Cancer:

6
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> T (p.Gly12Cys)single nucleotide variantPathogenicrs121913530GRCh37Chr 12, 25398285: 25398285
2FASLGNM_000639.1(FASLG): c.-844C=single nucleotide variantPathogenicrs763110GRCh37Chr 1, 172627498: 172627498
3PPP2R1BNM_181699.2(PPP2R1B): c.269G> A (p.Gly90Asp)single nucleotide variantPathogenicrs1805076GRCh37Chr 11, 111635566: 111635566
4SLC22A18NM_183233.2(SLC22A18): c.698C> T (p.Ser233Phe)single nucleotide variantPathogenicrs121909071GRCh37Chr 11, 2939260: 2939260

Expression for genes affiliated with Lung Cancer

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Expression patterns in normal tissues for genes affiliated with Lung Cancer

Search GEO for disease gene expression data for Lung Cancer.

Pathways for genes affiliated with Lung Cancer

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Pathways related to Lung Cancer according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.7EGFR, KRAS, RASSF1, FASLG, BRAF
210.7BRAF, FASLG, RASSF1, KRAS, EGFR
310.7EGFR, KRAS, FASLG, PPP2R1B
4
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
10.7BRAF, FASLG, KRAS, EGFR
5
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
10.7BRAF, FASLG, KRAS, EGFR
6
Show member pathways
MAPK signaling pathway37
10.7BRAF, FASLG, KRAS, EGFR
710.7BRAF, FASLG, KRAS, EGFR
8
Show member pathways
10.7EGFR, KRAS, BRAF, PPP2R1B
910.7PPP2R1B, BRAF, KRAS, EGFR
10
Show member pathways
10.7PPP2R1B, SPAG9, BRAF, KRAS
1110.7EGFR, KRAS, RASSF1, BRAF
12
Show member pathways
Signaling Pathways in Glioblastoma37
10.7BRAF, RASSF1, KRAS, EGFR
1310.6KRAS, BRAF, PPP2R1B
14
Show member pathways
10.6EGFR, KRAS, BRAF
15
Show member pathways
Signal transduction PTEN pathway60
10.6EGFR, KRAS, BRAF
16
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
10.6BRAF, KRAS, EGFR
17
Show member pathways
10.6BRAF, KRAS, EGFR
18
Show member pathways
EGFR-dependent Endothelin signaling events37
10.6EGFR, KRAS

Compounds for genes affiliated with Lung Cancer

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Compounds related to Lung Cancer according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1cisplatin44 50 61 1114.2BRAF, FASLG, GSTM1, RASSF1, KRAS, EGFR
2paclitaxel44 50 1113.1EGFR, KRAS, FASLG, BRAF, CYP2A6
3estrogen4411.1BRAF, FASLG, GSTM1, RASSF1, KRAS, EGFR
4retinoic acid44 2412.1CYP2A6, BRAF, FASLG, RASSF1, KRAS, EGFR
5aspartate4411.1GSTM1, ALDOA, FASLG, BRAF, PPP2R1B
6imatinib44 50 1113.0BRAF, FASLG, KRAS, EGFR
75-aza-2deoxycytidine4411.0RASSF1, DLEC1, CADM1, FASLG
8panitumumab44 50 1113.0EGFR, KRAS, BRAF
95fluorouracil4411.0FASLG, GSTM1, KRAS, EGFR
10regorafenib50 1112.0BRAF, KRAS, EGFR
11agar4411.0EGFR, RASSF1, FASLG, BRAF
12o6-methylguanine4411.0KRAS, RASSF1, BRAF
13cetuximab44 50 1113.0BRAF, KRAS, EGFR
14crcs4411.0KRAS, RASSF1, BRAF
15leucovorin44 50 1113.0FASLG, KRAS, EGFR
16oxaliplatin44 50 1112.9GSTM1, KRAS, EGFR
174-hydroxytamoxifen4410.9EGFR, FASLG, CYP2A6
18rapamycin4410.9EGFR, KRAS, FASLG, BRAF
19irinotecan44 50 1112.9EGFR, KRAS, BRAF
20phenobarbital44 28 50 1113.9GSTM1, CYP2A, CYP2A6
21cumene hydroperoxide4410.9GSTM1, CYP2A6
22ly2940024410.9BRAF, FASLG, KRAS, EGFR
23carboplatin44 50 1112.9FASLG, GSTM1, EGFR
24vinylchloride4410.8GSTM1, KRAS
25vegf4410.8BRAF, FASLG, ALDOA, KRAS, EGFR
26p0034410.8RASSF1, GSTM1, FASLG
27glutamate4410.7ERCC6, ALDOA, FASLG, BRAF, CYP2A6
28thymidylate4410.7EGFR, GSTM1, FASLG
29p0024410.6BRAF, GSTM1, KRAS
30debrisoquine44 5011.5CYP2A6, GSTM1
31paraffin4410.4BRAF, FASLG, KRAS, EGFR

GO Terms for genes affiliated with Lung Cancer

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Biological processes related to Lung Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1striated muscle cell differentiationGO:05114610.6KRAS, SPAG9

Molecular functions related to Lung Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.1SLC4A1AP, SPAG9, BRAF, FASLG, CADM1, ALDOA

Products for genes affiliated with Lung Cancer

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  • Antibodies
  • Proteins
  • Lysates

Sources for Lung Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet