MCID: LNG032
MIFTS: 61

Lung Cancer malady

Summaries for Lung Cancer

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Lung cancer is one of the most common cancers in the world. it is a leading cause of cancer death in men and women in the united states. cigarette smoking causes most lung cancers. the more cigarettes you smoke per day and the earlier you started smoking, the greater your risk of lung cancer. high levels of pollution, radiation and asbestos exposure may also increase risk. common symptoms of lung cancer include a cough that doesn't go away and gets worse over time constant chest pain coughing up blood shortness of breath, wheezing, or hoarseness repeated problems with pneumonia or bronchitis swelling of the neck and face loss of appetite or weight loss fatigue doctors diagnose lung cancer using a physical exam, imaging, and lab tests. treatment depends on the type, stage, and how advanced it is. treatments include surgery, chemotherapy, radiation therapy, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Lung Cancer, also known as carcinoma of lung, is related to adenocarcinoma and colorectal cancer. An important gene associated with Lung Cancer is CYP2A6 (cytochrome P450, family 2, subfamily A, polypeptide 6), and among its related pathways are Hepatitis C and 4-1BB Pathway. The compounds panitumumab and debrisoquine have been mentioned in the context of this disorder. Affiliated tissues include the lung.

Disease Ontology:8 A respiratory system cancer that is located in the lung.

CDC:3 Lung cancer is the leading cause of cancer death and the second most common cancer among both men and women in the United States.

Wikipedia:64 Lung cancer is a disease characterized by uncontrolled cell growth in tissues of the lung. If left... more...

Description from OMIM:47 612593,608935,211980,614210,612571

Aliases & Classifications for Lung Cancer

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 34MedlinePlus, 45Novoseek, 20GeneTests, 22GTR, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

lung cancer 8 47 10 34
carcinoma of lung 8 20 22 61
lung carcinoma 8 45
malignant neoplasm of lung 61
malignant neoplasms 61
cancer of lung 8
cancer lung 45


Related Diseases for Lung Cancer

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lung Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 616)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.1RASSF1, GSTM1, CYP2A6, EGFR, BRAF, CADM1
2colorectal cancer30.8GSTM1, RASSF1, CYP2A6, EGFR, PPP2R1B, BRAF
3nasopharynx carcinoma30.8EGFR, CYP2A6, CADM1, RASSF1, GSTM1
4oral cancer30.7EGFR, GSTM1
5thyroid cancer30.6BRAF, GSTM1, RASSF1
6adenoma30.5BRAF, GSTM1, RASSF1, CYP2A6
7stomach cancer30.3EGFR, CYP2A6, RASSF1, GSTM1, CADM1, BRAF
8wilms tumor30.2RASSF1, SLC22A18
9bladder carcinoma30.0GSTM1, EGFR, CYP2A6, RASSF1
10bladder carcinoma in situ29.8GSTM1, RASSF1, EGFR
11hepatitis c29.8CYP2A6, GSTM1
12lung cancer susceptibility11.1
13vascular cancer11.0
14hypoxia10.8
15asbestosis10.7
16small cell carcinoma10.7
17silicosis10.7
18brain cancer10.7
19thoracic cancer10.7
20lung cancer, somatic10.7
21lambert-eaton myasthenic syndrome10.6
22lambert syndrome10.6
23squamous cell carcinoma10.6
24pulmonary function10.6
25radiation induced cancer10.6
26paraneoplastic syndromes10.6
27lung lymphoma10.6
28tuberculosis10.6
29idiopathic pulmonary fibrosis10.5
30bone marrow cancer10.5
31pulmonary disease, chronic obstructive10.5
32bone carcinoma10.5
33n syndrome10.5
34superior vena cava syndrome10.4
35thrombocytosis10.4
36pulmonary tuberculosis10.4
37anaplastic small cell lymphoma10.4
38somatostatin analog10.4
39germ cell cancer10.4
40cryptococcosis10.4
41mutagen sensitivity10.4
42lung cancer susceptibility 510.4
43colon cancer, advanced10.4
44cardia cancer10.3
45hypercalcemia10.3
46bronchogenic carcinoma10.3
47nicotine dependence10.3
48limbic encephalitis10.3
49lung cancer, egfr-related10.3
50xeroderma pigmentosum10.3

Graphical network of the top 20 diseases related to Lung Cancer:



Diseases related to lung cancer

Clinical Features for Lung Cancer

Sources:
47OMIM
See all sources

Clinical features from OMIM:

612593,608935,211980,614210,612571

Clinical synopsis from OMIM:

211980

Drugs & Therapeutics for Lung Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lung Cancer

Drug clinical trials:

Search ClinicalTrials for Lung Cancer

Search NIH Clinical Center for Lung Cancer

Search CenterWatch for Lung Cancer

Genetic Tests for Lung Cancer

Sources:
20GeneTests, 22GTR
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Genetic tests related to Lung Cancer:

id Genetic test Affiliating Genes
1 Lung Cancer20 22 GSTM1

Anatomical Context for Lung Cancer

Sources:
14FMA
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FMA organs/tissues related to Lung Cancer:

14
The lung

Animal Models for Lung Cancer or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Lung Cancer

Sources:
51PubMed
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Articles related to Lung Cancer:

(show top 50)    (show all 10379)
idTitleAuthorsYear
1
Study protocol of a randomized controlled trial comparing Mindfulness-Based Stress Reduction with treatment as usual in reducing psychological distress in patients with lung cancer and their partners: the MILON study. (24386906)
2014
2
Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. (23144319)
2013
3
Chemotherapy for pulmonary large cell neuroendocrine carcinoma: similar to that for small cell lung cancer or non-small cell lung cancer? (22579297)
2012
4
Expression and pharmacological inhibition of thymidylate synthase and Src kinase in nonsmall cell lung cancer. (21618517)
2012
5
Small cell lung cancer metastasizing to the colon in a colovesicular fistula in the setting of diverticulitis. (22546106)
2012
6
Cytoplasmic expression of CDK4 protein and its correlation with the clinicopathologic features and prognosis of lung cancer]. (23174577)
2012
7
Effects of BTG2 on proliferation inhibition and anti-invasion in human lung cancer cells. (22392501)
2012
8
Mutation analysis of the FRK gene in non-small cell lung cancers. (21074287)
2011
9
Unexpected small bowel intussusception caused by lung cancer metastasis on 18F-fluorodeoxyglucose PET-CT. (21095361)
2010
10
Combinatorial library discovery of small molecule inhibitors of lung cancer proliferation and parathyroid hormone-related protein expression. (20890111)
2010
11
ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus. (20124469)
2010
12
Responses to online GSTM1 genetic test results among smokers related to patients with lung cancer: a pilot study. (19567511)
2009
13
Germline polymorphisms in EGFR and survival in patients with lung cancer receiving gefitinib. (17713473)
2008
14
Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting. (18611285)
2008
15
The CYP2A6*4 allele is determinant of S-1 pharmacokinetics in Japanese patients with non-small-cell lung cancer. (18212800)
2008
16
The prognostic value of cytokeratin 19 expression in non-small cell lung cancer]. (18080980)
2007
17
Polymorphisms in the epidermal growth factor receptor gene and the risk of primary lung cancer: a case-control study. (17956637)
2007
18
Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas. (18089789)
2007
19
Class III beta-tubulin expression and benefit from adjuvant cisplatin/vinorelbine chemotherapy in operable non-small cell lung cancer: analysis of NCIC JBR.10. (17289895)
2007
20
The interaction between microsomal epoxide hydrolase polymorphisms and indoor pollution in non small cell lung cancer]. (17767854)
2007
21
Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1. (17940500)
2007
22
The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer. (17908966)
2007
23
Prognostic impact of matrix metalloproteinases 2,9, and 11 in stromal cells stage I non-small cell lung cancer]. (17310584)
2007
24
Thrombotic microangiopathy in a sirolimus-treated renal transplant patient receiving gemcitabine for lung cancer. (17338432)
2007
25
Maspin expression and its clinical significance in non-small cell lung cancer. (17009165)
2006
26
Polymorphism of the DNA repair gene ERCC2 Lys751Gln and risk of lung cancer in a northeastern Chinese population. (16875933)
2006
27
Natural killer cell-mediated rejection of experimental human lung cancer by genetic overexpression of major histocompatibility complex class I chain-related gene A. (16454647)
2006
28
Plasma fibrinogen and serum C-reactive protein are associated with non-small cell lung cancer. (16698114)
2006
29
Induction of apoptosis of lung and esophageal cancer cells treated with the combination of histone deacetylase inhibitor (trichostatin A) and protein kinase C inhibitor (calphostin C). (15632825)
2005
30
Selection of GM2, fucosyl GM1, globo H and polysialic acid as targets on small cell lung cancers for antibody mediated immunotherapy. (15926079)
2005
31
Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis. (12898601)
2003
32
Inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase enhances chemotherapeutic effects on H460 human non-small cell lung cancer cells through activation of apoptosis. (12883037)
2003
33
Detection of P53 and K-ras gene mutations in lung cancer with oligonucleotide chip]. (12385241)
2002
34
Genetic polymorphisms in N-acetyltransferase-2 and microsomal epoxide hydrolase, cumulative cigarette smoking, and lung cancer. (11815396)
2002
35
Defected expression of E-cadherin in non-small cell lung cancer. (12140137)
2002
36
Differential osteopontin expression in lung cancer. (11520606)
2001
37
A case of lung and pleural metastases from breast cancer responding to toremifene]. (11242650)
2001
38
RARbeta2 specificity in mediating RA inhibition of growth of lung cancer-derived cells. (10717330)
2000
39
Detection of circulating tumor cells by reverse transcriptase-polymerase chain reaction in patients with resectable non-small-cell lung cancer. (10568179)
1999
40
Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers. (10597320)
1999
41
Evaluation of chemotherapy response in patients with small cell lung cancer using Technetium-99m-tetrofosmin. (10472350)
1999
42
Induction of differentiation accompanies inhibition of Cdk2 in a non-small cell lung cancer cell line. (10375610)
1999
43
Differentiation and programmed cell death-related intermediate biomarkers for the development of non-small cell lung cancer: a pilot study. (9744313)
1998
44
Problems and recommendations for use of G-CSF in lung cancer patients with neutropenia after chemotherapy]. (9369920)
1997
45
Cigarette smoking and p53 mutations in lung cancer and bladder cancer. (8781382)
1996
46
PCNA expression and AgNORs image analysis as factors in judging the prognosis of lung cancer]. (7656378)
1995
47
The role of hematopoietic growth factors in small cell lung cancer: a review. (7535555)
1995
48
Effect of intravenous immunoglobulin in Lambert-Eaton myasthenic syndrome with small-cell lung cancer: correlation with the titer of anti-voltage-gated calcium channel antibody. (8065398)
1994
49
Efficacy of recombinant human granulocyte-macrophage colony-stimulating factor for chemotherapy-induced leukopenia in patients with non-small-cell lung cancer. (8174201)
1994
50
Clinical significance of serum carcinoembryonic antigen in small cell lung cancer patients]. (1318435)
1992

Genetic Variations for Lung Cancer

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Lung Cancer:

63
id Symbol AA change Variation SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Expression for genes affiliated with Lung Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Cancer

Search GEO for disease gene expression data for Lung Cancer.

Pathways for genes affiliated with Lung Cancer

Sources:
30KEGG, 52QIAGEN, 12EMD Millipore
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Pathways related to Lung Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2EGFR, PPP2R1B, BRAF
2
Hide members
11.2EGFR, PPP2R1B, BRAF
311.2RASSF1, EGFR, BRAF

Compounds for genes affiliated with Lung Cancer

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR
See all sources

Compounds related to Lung Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1panitumumab45 50 1112.9EGFR, BRAF
2debrisoquine4510.9GSTM1, CYP2A6
3phenobarbital45 29 1112.9GSTM1, CYP2A, CYP2A6
4cumene hydroperoxide4510.8GSTM1, CYP2A6

GO Terms for genes affiliated with Lung Cancer

Products for genes affiliated with Lung Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lung Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet