MCID: LNG032
MIFTS: 74

Lung Cancer malady

Respiratory diseases, Cancer diseases categories

Summaries for Lung Cancer

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Lung cancer is one of the most common cancers in the world. it is a leading cause of cancer death in men and women in the united states. cigarette smoking causes most lung cancers. the more cigarettes you smoke per day and the earlier you started smoking, the greater your risk of lung cancer. high levels of pollution, radiation and asbestos exposure may also increase risk. common symptoms of lung cancer include a cough that doesn't go away and gets worse over time constant chest pain coughing up blood shortness of breath, wheezing, or hoarseness repeated problems with pneumonia or bronchitis swelling of the neck and face loss of appetite or weight loss fatigue doctors diagnose lung cancer using a physical exam, imaging, and lab tests. treatment depends on the type, stage, and how advanced it is. treatments include surgery, chemotherapy, radiation therapy, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Lung Cancer, also known as carcinoma of lung, is related to breast cancer and lung adenocarcinoma. An important gene associated with Lung Cancer is CYP2A6 (cytochrome P450, family 2, subfamily A, polypeptide 6), and among its related pathways are Hepatitis C and 4-1BB Pathway. The compounds panitumumab and debrisoquine have been mentioned in the context of this disorder. Affiliated tissues include the lung, lung and breast.

Disease Ontology:8 A respiratory system cancer that is located in the lung.

CDC:3 Lung cancer is the leading cause of cancer death and the second most common cancer among both men and women in the United States.

Wikipedia:63 Lung cancer (also known as carcinoma of the lung) is a malignant lung tumor characterized by... more...

Description from OMIM:46 612593,608935,211980,614210,612571

Aliases & Classifications for Lung Cancer

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 33MedlinePlus, 44Novoseek, 20GeneTests, 22GTR, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

lung cancer 8 46 10 33
carcinoma of lung 8 20 22 60
lung carcinoma 8 44
malignant neoplasm of lung 60
malignant neoplasms 60
cancer of lung 8
cancer lung 44


Related Diseases for Lung Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Lung Cancer family:

Lung Carcinoma in Situ Lung Benign Neoplasm
Lung Cancer, Egfr-Related Lung Cancer, Gstm1-Related

Diseases related to Lung Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 985)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.2CADM1, PPP2R1B, GSTM1, CYP2A6, BRAF, RASSF1
2lung adenocarcinoma31.0GSTM1, EGFR, BRAF, CADM1, RASSF1
3adenocarcinoma31.0RASSF1, GSTM1, CYP2A6, EGFR, BRAF, CADM1
4non-small cell lung carcinoma30.9BRAF, EGFR, RASSF1, GSTM1
5nasopharynx carcinoma30.9EGFR, CYP2A6, CADM1, RASSF1, GSTM1
6esophageal cancer30.8DLEC1, EGFR
7colorectal cancer30.7GSTM1, RASSF1, CYP2A6, EGFR, PPP2R1B, BRAF
8colon cancer30.7BRAF, PPP2R1B, EGFR, RASSF1, GSTM1, CYP2A6
9leukemia30.7ALDOA, GSTM1
10melanoma30.6BRAF, PPP2R1B, RASSF1
11ovarian cancer30.6EGFR, PPP2R1B, RASSF1, BRAF
12prostate cancer30.5GSTM1, RASSF1, DLEC1, DLC1, MAEA, EGFR
13thyroid cancer30.5BRAF, GSTM1, RASSF1
14stomach cancer30.3EGFR, CYP2A6, RASSF1, GSTM1, CADM1, BRAF
15adenoma30.2BRAF, GSTM1, RASSF1, CYP2A6
16kidney cancer30.2RASSF1, EGFR, ALDOA, BRAF
17sarcoma30.2BRAF, GSTM1
18hepatitis30.2CYP2A6
19cervical cancer30.1GSTM1, RASSF1, EGFR, CADM1
20bladder carcinoma30.0GSTM1, EGFR, CYP2A6, RASSF1
21lung benign neoplasm29.8CADM1, EGFR, CYP2A6, RASSF1
22bladder carcinoma in situ29.8GSTM1, RASSF1, EGFR
23hepatocellular carcinoma29.8GSTM1, RASSF1, DLC1, CYP2A6, PPP2R1B, CADM1
24meningioma29.8CADM1
25familial adenomatous polyposis29.8RASSF1, BRAF
26cervical adenocarcinoma29.7RASSF1
27vascular cancer11.0
28cell type cancer10.9
29lymph node cancer10.8
30neuronitis10.8
31pleural cancer10.8
32asbestosis10.7
33silicosis10.7
34brain cancer10.7
35lung small cell carcinoma10.7
36small cell carcinoma10.7
37thoracic cancer10.6
38interstitial lung disease10.6
39lambert-eaton myasthenic syndrome10.6
40lung squamous cell carcinoma10.6
41lip cancer10.6
42squamous cell carcinoma10.6
43esophagitis10.6
44pneumonia10.5
45retinoblastoma10.5
46neutropenia10.5
47pulmonary fibrosis10.5
48tuberculosis10.5
49lung lymphoma10.5
50hypopharynx cancer10.5

Graphical network of the top 20 diseases related to Lung Cancer:



Diseases related to lung cancer

Clinical Features for Lung Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

612593,608935,211980,614210,612571

Clinical synopsis from OMIM:

211980

Drugs & Therapeutics for Lung Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lung Cancer

Drug clinical trials:

Search ClinicalTrials for Lung Cancer

Search NIH Clinical Center for Lung Cancer

Search CenterWatch for Lung Cancer

Genetic Tests for Lung Cancer

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Sources:
20GeneTests, 22GTR
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Genetic tests related to Lung Cancer:

id Genetic test Affiliating Genes
1 Lung Cancer20 22 GSTM1

Anatomical Context for Lung Cancer

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Lung Cancer:

32
Lung, Breast, Endothelial, Lymph node, Bone, Testes, Prostate, Colon, Brain, Liver, Testis, T cells, Thyroid, Bone marrow, Monocytes, Kidney, Skin, Pituitary, Heart, Bronchial epithelium, Placenta, Cervix, Nk cells, Myeloid, Tongue, Small intestine, Whole blood, Salivary gland, Spinal cord, Skeletal muscle, Pancreas, Ovary, B cells

FMA organs/tissues related to Lung Cancer:

14
The lung

Animal Models for Lung Cancer or affiliated genes

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Publications for Lung Cancer

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Sources:
50PubMed
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Articles related to Lung Cancer:

(show top 50)    (show all 10371)
idTitleAuthorsYear
1
Lung cancer in situs inversus totalis (SIT)--literature review. (23773970)
2013
2
Dual EGFR inhibition in combination with anti-VEGF treatment: a phase I clinical trial in non-small cell lung cancer. (23435217)
2013
3
The role of ZFX in non-small cell lung cancer development. (23461064)
2012
4
TNF receptor-associated factor 6 in advanced non-small cell lung cancer: clinical and prognostic implications. (22736025)
2012
5
A novel mass spectrometry-based assay for diagnosis of EML4-ALK-positive non-small cell lung cancer. (22722791)
2012
6
KIR2DL2/S2 and HLA-C C1C1 genotype is associated with better response to treatment and prolonged survival of patients with non-small cell lung cancer in a Polish Caucasian population. (22836042)
2012
7
Blockade of interleukin-6 receptor suppresses the proliferation of H460 lung cancer stem cells. (22552503)
2012
8
ALK fusion gene positive lung cancer and 3 cases treated with an inhibitor for ALK kinase activity. (21757253)
2012
9
Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis. (22064654)
2012
10
hOGG1, p53 genes, and smoking interactions are associated with the development of lung cancer. (22901126)
2012
11
HIF1I+ regulated expression of XPA contributes to cisplatin resistance in lung cancer. (22467238)
2012
12
Evaluation of Kras gene mutation and copy number gain in non-small cell lung cancer. (21150464)
2011
13
Evidence of the cross talk between Wnt and Notch signaling pathways in non-small-cell lung cancer (NSCLC): Notch3-siRNA weakens the effect of LiCl on the cell cycle of NSCLC cell lines. (20614134)
2011
14
Growth suppression of human lung cancer cells and implanted tumors by adenovirus-mediated transfer of the PTEN gene. (20407863)
2010
15
Features of potentially predictive biomarkers of chemotherapeutic efficacy in small cell lung cancer. (20107425)
2010
16
Lack of influence of XRCC1 and XPD gene polymorphisms on outcome of platinum-based chemotherapy for advanced non small cell lung cancers. (20104979)
2009
17
A meta-analysis of TP53 codon 72 polymorphism and lung cancer risk: evidence from 15,857 subjects. (19178978)
2009
18
Phase I dose escalation, pharmacokinetic and pharmacodynamic study of naptumomab estafenatox alone in patients with advanced cancer and with docetaxel in patients with advanced non-small-cell lung cancer. (19636016)
2009
19
Primary lung cancer and TNF-alpha gene polymorphisms: a case-control study in a Croatian population. (19564826)
2009
20
SOX antibodies in small-cell lung cancer and Lambert-Eaton myasthenic syndrome: frequency and relation with survival. (19667272)
2009
21
Erlotinib induces mitochondrial-mediated apoptosis in human H3255 non-small-cell lung cancer cells with epidermal growth factor receptorL858R mutation through mitochondrial oxidative phosphorylation-dependent activation of BAX and BAK. (18524889)
2008
22
First-generation epidermal growth factor receptor tyrosine kinase inhibitors in EGFR mutation: positive non-small cell lung cancer patients. (18520299)
2008
23
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. (18316592)
2008
24
Antitumor activity of noscapine in human non-small cell lung cancer xenograft model. (18338172)
2008
25
Plasmacytoid dendritic cells from human lung cancer draining lymph nodes induce Tc1 responses. (17023687)
2007
26
Expression peculiarities of EGR1, neurotrophins and their receptor genes in human lung cancer and in normal lung tissue]. (17600921)
2007
27
Tagging single nucleotide polymorphisms in excision repair cross-complementing group 1 (ERCC1) and risk of primary lung cancer in a Chinese population. (17502833)
2007
28
Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) has potential tumour-suppressive activity in human lung cancer. (17236181)
2007
29
Toxicities of antiangiogenic therapy in non-small-cell lung cancer. (17239287)
2006
30
Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosis. (16337338)
2006
31
Gene transfer mediated by native versus fibroblast growth factor-retargeted adenoviral vectors into lung cancer cells. (15626775)
2005
32
HLA alleles and lung cancer in a Turkish population. (15323271)
2004
33
Synergistic induction of the Fas (CD95) ligand promoter by Max and NFkappaB in human non-small lung cancer cells. (15302589)
2004
34
p73 G4C14-to-A4T14 polymorphism and risk of lung cancer. (15466174)
2004
35
Analysis of Fas (Apo-1/CD95) expression in non-small cell lung cancer. (14981943)
2003
36
Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways. (12660005)
2003
37
Genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes and lung cancer risk. (14534704)
2003
38
Endobronchial lipoma accompanied with primary lung cancer: report of a case. (12061688)
2002
39
Comparative study of bone resorption markers for the diagnosis of bone metastasis in lung cancer]. (12166253)
2002
40
C-erbB-2 expression and its relationship with ploidy, p53 abnormalities and epidermal growth factor receptor content in human non-small cell lung cancer. (10481927)
1999
41
Prognostic significance of different biomarkers in non-small cell lung cancer. (10373663)
1999
42
The relationship between CYP1A1 aryl hydrocarbon hydroxylase activity and lung cancer in a Japanese population. (9731718)
1998
43
Salvage treatment with paclitaxel and gemcitabine for patients with non-small-cell lung cancer after cisplatin- or docetaxel-based chemotherapy: a multicenter phase II study. (9834827)
1998
44
Criteria of functional and oncological operability in surgery for lung cancer: a multicenter study. The Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pneumology and Thoracic Surgery (GCCB-S). (9733050)
1998
45
Is there a lung-cancer susceptibility gene? (9221817)
1997
46
IA-2, a transmembrane protein tyrosine phosphatase, is expressed in human lung cancer cell lines with neuroendocrine phenotype. (8665506)
1996
47
Reduced levels of topoisomerase II alpha and II beta in a multidrug-resistant lung-cancer cell line. (8004758)
1994
48
Growth suppression by transforming growth factor beta 1 of human small-cell lung cancer cell lines is associated with expression of the type II receptor. (8180008)
1994
49
Inhibition of growth of human small cell lung cancer by bromocriptine. (8012964)
1994
50
Value of serum neuron-specific enolase in nonsmall cell lung cancer. (8383830)
1993

Genetic Variations for Lung Cancer

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Lung Cancer:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Expression for genes affiliated with Lung Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Cancer

Search GEO for disease gene expression data for Lung Cancer.

Pathways for genes affiliated with Lung Cancer

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29KEGG, 51QIAGEN, 12EMD Millipore
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Pathways related to Lung Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2EGFR, PPP2R1B, BRAF
2
Hide members
11.2EGFR, PPP2R1B, BRAF
311.2RASSF1, EGFR, BRAF

Compounds for genes affiliated with Lung Cancer

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR
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Compounds related to Lung Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1panitumumab44 49 1112.9EGFR, BRAF
2debrisoquine4410.9GSTM1, CYP2A6
3phenobarbital44 28 1112.9GSTM1, CYP2A, CYP2A6
4cumene hydroperoxide4410.8GSTM1, CYP2A6

GO Terms for genes affiliated with Lung Cancer

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Products for genes affiliated with Lung Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lung Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet