MCID: LNG032
MIFTS: 74

Lung Cancer malady

Respiratory diseases, Cancer diseases categories

Summaries for Lung Cancer

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Lung cancer is one of the most common cancers in the world. it is a leading cause of cancer death in men and women in the united states. cigarette smoking causes most lung cancers. the more cigarettes you smoke per day and the earlier you started smoking, the greater your risk of lung cancer. high levels of pollution, radiation and asbestos exposure may also increase risk. common symptoms of lung cancer include a cough that doesn't go away and gets worse over time constant chest pain coughing up blood shortness of breath, wheezing, or hoarseness repeated problems with pneumonia or bronchitis swelling of the neck and face loss of appetite or weight loss fatigue doctors diagnose lung cancer using a physical exam, imaging, and lab tests. treatment depends on the type, stage, and how advanced it is. treatments include surgery, chemotherapy, radiation therapy, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. nih: national cancer institute

MalaCards: Lung Cancer, also known as carcinoma of lung, is related to breast cancer and lung adenocarcinoma. An important gene associated with Lung Cancer is CYP2A6 (cytochrome P450, family 2, subfamily A, polypeptide 6), and among its related pathways are Hepatitis C and 4-1BB Pathway. The compounds panitumumab and debrisoquine have been mentioned in the context of this disorder. Affiliated tissues include the lung, lung and breast.

Disease Ontology:8 A respiratory system cancer that is located in the lung.

CDC:3 Lung cancer is the leading cause of cancer death and the second most common cancer among both men and women in the United States.

Wikipedia:63 Lung cancer (also known as carcinoma of the lung) is a malignant lung tumor characterized by... more...

Description from OMIM:46 612593,608935,211980,614210,612571

Aliases & Classifications for Lung Cancer

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 33MedlinePlus, 44Novoseek, 20GeneTests, 22GTR, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

lung cancer 8 46 10 33
carcinoma of lung 8 20 22 60
lung carcinoma 8 44
malignant neoplasm of lung 60
malignant neoplasms 60
cancer of lung 8
cancer lung 44


Related Diseases for Lung Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Lung Cancer family:

Lung Carcinoma in Situ Lung Benign Neoplasm
Lung Cancer, Egfr-Related Lung Cancer, Gstm1-Related

Diseases related to Lung Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 985)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.2CADM1, PPP2R1B, GSTM1, CYP2A6, BRAF, RASSF1
2lung adenocarcinoma31.0GSTM1, EGFR, BRAF, CADM1, RASSF1
3adenocarcinoma31.0RASSF1, GSTM1, CYP2A6, EGFR, BRAF, CADM1
4non-small cell lung carcinoma30.9BRAF, EGFR, RASSF1, GSTM1
5nasopharynx carcinoma30.9EGFR, CYP2A6, CADM1, RASSF1, GSTM1
6esophageal cancer30.8DLEC1, EGFR
7colorectal cancer30.7GSTM1, RASSF1, CYP2A6, EGFR, PPP2R1B, BRAF
8colon cancer30.7BRAF, PPP2R1B, EGFR, RASSF1, GSTM1, CYP2A6
9leukemia30.7ALDOA, GSTM1
10melanoma30.6BRAF, PPP2R1B, RASSF1
11ovarian cancer30.6EGFR, PPP2R1B, RASSF1, BRAF
12prostate cancer30.5GSTM1, RASSF1, DLEC1, DLC1, MAEA, EGFR
13thyroid cancer30.5BRAF, GSTM1, RASSF1
14stomach cancer30.3EGFR, CYP2A6, RASSF1, GSTM1, CADM1, BRAF
15adenoma30.2BRAF, GSTM1, RASSF1, CYP2A6
16kidney cancer30.2RASSF1, EGFR, ALDOA, BRAF
17sarcoma30.2BRAF, GSTM1
18hepatitis30.2CYP2A6
19cervical cancer30.1GSTM1, RASSF1, EGFR, CADM1
20bladder carcinoma30.0GSTM1, EGFR, CYP2A6, RASSF1
21lung benign neoplasm29.8CADM1, EGFR, CYP2A6, RASSF1
22bladder carcinoma in situ29.8GSTM1, RASSF1, EGFR
23hepatocellular carcinoma29.8GSTM1, RASSF1, DLC1, CYP2A6, PPP2R1B, CADM1
24meningioma29.8CADM1
25familial adenomatous polyposis29.8RASSF1, BRAF
26cervical adenocarcinoma29.7RASSF1
27vascular cancer11.0
28cell type cancer10.9
29lymph node cancer10.8
30neuronitis10.8
31pleural cancer10.8
32asbestosis10.7
33silicosis10.7
34brain cancer10.7
35lung small cell carcinoma10.7
36small cell carcinoma10.7
37thoracic cancer10.6
38interstitial lung disease10.6
39lambert-eaton myasthenic syndrome10.6
40lung squamous cell carcinoma10.6
41lip cancer10.6
42squamous cell carcinoma10.6
43esophagitis10.6
44pneumonia10.5
45retinoblastoma10.5
46neutropenia10.5
47pulmonary fibrosis10.5
48tuberculosis10.5
49lung lymphoma10.5
50hypopharynx cancer10.5

Graphical network of the top 20 diseases related to Lung Cancer:



Diseases related to lung cancer

Clinical Features for Lung Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

612593,608935,211980,614210,612571

Clinical synopsis from OMIM:

211980

Drugs & Therapeutics for Lung Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lung Cancer

Drug clinical trials:

Search ClinicalTrials for Lung Cancer

Search NIH Clinical Center for Lung Cancer

Search CenterWatch for Lung Cancer

Genetic Tests for Lung Cancer

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Sources:
20GeneTests, 22GTR
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Genetic tests related to Lung Cancer:

id Genetic test Affiliating Genes
1 Lung Cancer20 22 GSTM1

Anatomical Context for Lung Cancer

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Lung Cancer:

32
Lung, Breast, Endothelial, Lymph node, Bone, Testes, Prostate, Colon, Brain, Liver, Testis, T cells, Thyroid, Bone marrow, Monocytes, Kidney, Pituitary, Skin, Heart, Bronchial epithelium, Myeloid, Nk cells, Placenta, Cervix, Tongue, Salivary gland, Small intestine, Whole blood, Ovary, Pancreas, Skeletal muscle, B cells, Spinal cord

FMA organs/tissues related to Lung Cancer:

14
The lung

Animal Models for Lung Cancer or affiliated genes

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Publications for Lung Cancer

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Sources:
50PubMed
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Articles related to Lung Cancer:

(show top 50)    (show all 10371)
idTitleAuthorsYear
1
Evaluation of a novel rash scale and a serum proteomic predictor in a randomized phase II trial of sequential or concurrent cetuximab and pemetrexed in previously treated non-small cell lung cancer. (24386952)
2014
2
HEDGEHOG-GLI signaling inhibition suppresses tumor growth in squamous lung cancer. (24423612)
2014
3
Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma. (24367082)
2014
4
Venous Thromboembolism in Patients Undergoing Operations for Lung Cancer: A Systematic Review. (24365217)
2013
5
Neurological outcome after emergency radiotherapy in MSCC of patients with non-small cell lung cancer - a prospective trial. (24373638)
2013
6
Breast cancer susceptibility gene 1 (BRCA1) predict clinical outcome in platinum- and toxal-based chemotherapy in non-small-cell lung cancer (NSCLC) patients: a system review and meta-analysis. (23497550)
2013
7
Diagnosing peripheral lung cancer: the additional value of the Ras-association domain family 1A gene methylation and Kirsten rat sarcoma 2 viral oncogene homolog mutation analyses in washings in nondiagnostic bronchoscopy. (21700687)
2012
8
Rapid-onset hypogonadism secondary to crizotinib use in men with metastatic nonsmall cell lung cancer. (22488744)
2012
9
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. (22225612)
2012
10
Prognostic role of microRNA-21 in non-small cell lung cancer: a meta-analysis. (22901216)
2012
11
EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study. (22056021)
2012
12
Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer. (21610322)
2011
13
Dual paraneoplastic syndromes in a patient with small cell lung cancer: a case report. (21771301)
2011
14
Somatic EGFR mutation and gene copy gain as predictive biomarkers for response to tyrosine kinase inhibitors in non-small cell lung cancer. (20028749)
2010
15
Targeting specific regions of the Notch3 ligand-binding domain induces apoptosis and inhibits tumor growth in lung cancer. (20068176)
2010
16
A polymorphism in the hMLH1 gene (-93G-->A) associated with lung cancer susceptibility and prognosis. (19956916)
2010
17
ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer. (20551051)
2010
18
Serum levels of HMGB1, survivin, and VEGF in patients with advanced non-small cell lung cancer during chemotherapy. (20430742)
2009
19
Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment. (19805294)
2009
20
High levels of oxidative stress in patients with advanced lung cancer. (18197920)
2008
21
Prognostic significance of DNA repair proteins MLH1, MSH2 and MGMT expression in non-small-cell lung cancer and precursor lesions. (18370958)
2008
22
Nuclear and cytoplasmic cellular distribution of survivin as survival predictor in resected non-small-cell lung cancer. (17693049)
2008
23
Efficacy of gemcitabine in patients with non-small cell lung cancer according to promoter polymorphisms of the ribonucleotide reductase M1 gene. (18483375)
2008
24
IGF-1 and IGFBP-3: Risk of prostate cancer among men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. (17597108)
2007
25
Growth inhibition and induction of G1 phase cell cycle arrest in human lung cancer cells by a phenylbutenoid dimer isolated from Zingiber cassumunar. (17666821)
2007
26
Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. (17936562)
2007
27
Clonal and parallel evolution of primary lung cancers and their metastases revealed by molecular dissection of cancer cells. (17200345)
2007
28
+61A>G polymorphism in the EGF gene does not increase the risk of lung cancer. (17986122)
2007
29
Detection of epidermal growth factor receptor mutation in transbronchial needle aspirates of non-small cell lung cancer. (17565015)
2007
30
Decoy receptor-2 small interfering RNA (siRNA) strategy employing three different siRNA constructs in combination defeats adenovirus-transferred tumor necrosis factor-related apoptosis-inducing ligand resistance in lung cancer cells. (17187448)
2007
31
Repeat prostate biopsy in the prostate, lung, colorectal and ovarian cancer screening trial. (17223921)
2007
32
EGF-independent activation of cell-surface EGF receptors harboring mutations found in gefitinib-sensitive lung cancer. (16953218)
2007
33
Perioperative cyclooxygenase 2 inhibition to reduce tumor cell adhesion and metastatic potential of circulating tumor cells in non-small cell lung cancer. (16872953)
2006
34
Combined detection of CEA mRNA and CK 19 mRNA in peripheral blood cells of patients with lung cancer]. (15312354)
2004
35
Expression of keratinocyte growth factor/fibroblast growth factor-7 and its receptor in human lung cancer: correlation with tumour proliferative activity and patient prognosis. (15307144)
2004
36
Prodigiosin induces apoptosis by acting on mitochondria in human lung cancer cells. (15033716)
2003
37
Loss of cables protein expression in human non-small cell lung cancer: a tissue microarray study. (12612882)
2003
38
The role of carotenoids on the risk of lung cancer. (12635093)
2003
39
Expression of p21 and bcl-2 proteins in paraffin-embedded preparations of non-small cell lung cancer in stage IIIA after Etoposide and Cisplatin induced chemotherapy. (15314975)
2003
40
Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). (11956076)
2002
41
Irinotecan and platinums in the treatment of non small-cell lung cancer. (14725725)
2001
42
Up-regulation of the proapoptotic mediators Bax and Bak after adenovirus-mediated p53 gene transfer in lung cancer cells. (10741712)
2000
43
An autopsy case of diffuse panbronchiolitis associated with lung cancer. (10830183)
2000
44
Thrombospondin 2 gene expression is correlated with decreased vascularity in non-small cell lung cancer. (9676856)
1998
45
Association between lung cancer and microsomal epoxide hydrolase genotypes. (9850050)
1998
46
Diagnostic value of p53 protein examination in lung cancer through preoperative fibro-optic bronchoscope brushing and biospy]. (10920941)
1998
47
Two COOH-terminal truncated cytoplasmic forms of topoisomerase II alpha in a VP-16-selected lung cancer cell line result from partial gene deletion and alternative splicing. (9153428)
1997
48
Does the assessment of serum markers in patients with lung cancer aid in the clinical decision making process? (8694537)
1996
49
Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases. (9064358)
1996
50
Trends in lung, stomach, breast and colorectal cancer in the Republic of Ireland. (6526636)
1984

Genetic Variations for Lung Cancer

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Lung Cancer:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Expression for genes affiliated with Lung Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Cancer

Search GEO for disease gene expression data for Lung Cancer.

Pathways for genes affiliated with Lung Cancer

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29KEGG, 51QIAGEN, 12EMD Millipore
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Pathways related to Lung Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2EGFR, PPP2R1B, BRAF
2
Hide members
11.2EGFR, PPP2R1B, BRAF
311.2RASSF1, EGFR, BRAF

Compounds for genes affiliated with Lung Cancer

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR
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Compounds related to Lung Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1panitumumab44 49 1112.9EGFR, BRAF
2debrisoquine4410.9GSTM1, CYP2A6
3phenobarbital44 28 1112.9GSTM1, CYP2A, CYP2A6
4cumene hydroperoxide4410.8GSTM1, CYP2A6

GO Terms for genes affiliated with Lung Cancer

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Products for genes affiliated with Lung Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lung Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet