MCID: LNG061
MIFTS: 29

Lung Cancer, Somatic malady

Genetic diseases (common), Respiratory diseases, Cancer diseases categories

Summaries for Lung Cancer, Somatic

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MAP3K8 antibody
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MalaCards based summary: Lung Cancer, Somatic is related to lung cancer and nonsmall cell lung cancer, somatic. An important gene associated with Lung Cancer, Somatic is KRAS (Kirsten rat sarcoma viral oncogene homolog), and among its related pathways are Signaling by Interleukins and Signalling to ERKs. The compounds panitumumab and regorafenib have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Description from OMIM:46 211980

Aliases & Classifications for Lung Cancer, Somatic

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Lung Cancer, Somatic, Aliases & Descriptions:

Name: Lung Cancer, Somatic 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases
Anatomical: Respiratory diseases


Related Diseases for Lung Cancer, Somatic

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Graphical network of the top 20 diseases related to Lung Cancer, Somatic:



Diseases related to lung cancer, somatic

Symptoms for Lung Cancer, Somatic

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Clinical features from OMIM:

211980

Drugs & Therapeutics for Lung Cancer, Somatic

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Drug clinical trials:

Search ClinicalTrials for Lung Cancer, Somatic

Search NIH Clinical Center for Lung Cancer, Somatic

Genetic Tests for Lung Cancer, Somatic

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Anatomical Context for Lung Cancer, Somatic

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MalaCards organs/tissues related to Lung Cancer, Somatic:

32
Lung

Animal Models for Lung Cancer, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Lung Cancer, Somatic:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5BRAF, FASLG, MAP3K8, KRAS
2MP:00053978.5MAP3K8, FASLG, BRAF, KRAS
3MP:00053818.4KRAS, MAP3K8, FASLG, BRAF
4MP:00053858.2KRAS, BRAF, FASLG, MAP3K8

Publications for Lung Cancer, Somatic

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Variations for Lung Cancer, Somatic

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UniProtKB/Swiss-Prot genetic disease variations for Lung Cancer, Somatic:

63
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Clinvar genetic disease variations for Lung Cancer, Somatic:

7
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> T (p.Gly12Cys)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
2FASLGNM_000639.1(FASLG): c.-844C=single nucleotide variantPathogenic, risk factorrs763110GRCh37Chr 1, 172627498: 172627498
3PPP2R1BNM_181699.2(PPP2R1B): c.269G> A (p.Gly90Asp)single nucleotide variantPathogenicrs1805076GRCh37Chr 11, 111635566: 111635566
4SLC22A18NM_183233.2(SLC22A18): c.698C> T (p.Ser233Phe)single nucleotide variantPathogenicrs121909071GRCh37Chr 11, 2939260: 2939260

Expression for genes affiliated with Lung Cancer, Somatic

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Expression patterns in normal tissues for genes affiliated with Lung Cancer, Somatic

Search GEO for disease gene expression data for Lung Cancer, Somatic.

Pathways for genes affiliated with Lung Cancer, Somatic

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Pathways related to Lung Cancer, Somatic according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6MAP3K8, KRAS
2
Show member pathways
9.5BRAF, KRAS
3
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells59
Oncostatin M Signaling Pathway37
9.5KRAS, BRAF
49.5BRAF, KRAS
59.5KRAS, BRAF
6
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.5KRAS, BRAF
79.5KRAS, BRAF
8
Show member pathways
9.5BRAF, KRAS
9
Show member pathways
9.5BRAF, KRAS
10
Show member pathways
9.5BRAF, KRAS
11
Show member pathways
9.5KRAS, BRAF
12
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway59
9.5KRAS, BRAF
139.5KRAS, BRAF
149.5BRAF, KRAS
15
Show member pathways
9.5BRAF, KRAS
16
Show member pathways
Signal transduction PTEN pathway59
9.5KRAS, BRAF
179.4MAP3K8, FASLG
18
Show member pathways
9.4MAP3K8, FASLG
199.2PPP2R1B, KRAS
20
Show member pathways
9.2MAP3K8, PPP2R1B
21
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.0PPP2R1B, FASLG
22
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
8.9BRAF, FASLG, KRAS
238.9KRAS, BRAF, FASLG
24
Show member pathways
Immune response CD16 signaling in NK cells59
8.9KRAS, BRAF, FASLG
25
Show member pathways
8.9FASLG, KRAS, BRAF
26
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.9FASLG, BRAF, KRAS
278.9FASLG, KRAS, BRAF
28
Show member pathways
Ras signaling in the CD4+ TCR pathway37
8.9MAP3K8, FASLG, BRAF
29
Show member pathways
8.8KRAS, MAP3K8, PPP2R1B
30
Show member pathways
8.7PPP2R1B, KRAS, BRAF
31
Show member pathways
8.7KRAS, BRAF, PPP2R1B
32
Show member pathways
8.7PPP2R1B, BRAF, KRAS
33
Show member pathways
8.7BRAF, KRAS, PPP2R1B
348.7KRAS, BRAF, PPP2R1B
358.7PPP2R1B, KRAS, BRAF
36
Show member pathways
8.7BRAF, PPP2R1B, MAP3K8
37
Show member pathways
8.7BRAF, PPP2R1B, MAP3K8
38
Show member pathways
8.7MAP3K8, BRAF, PPP2R1B
398.6PPP2R1B, FASLG, KRAS
40
Show member pathways
8.5BRAF, PPP2R1B, FASLG
41
Show member pathways
MAPK signaling pathway37
8.5KRAS, BRAF, FASLG, MAP3K8
42
Show member pathways
8.3BRAF, PPP2R1B, MAP3K8, KRAS
43
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.2FASLG, MAP3K8, PPP2R1B, KRAS

Compounds for genes affiliated with Lung Cancer, Somatic

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Compounds related to Lung Cancer, Somatic according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1panitumumab44 50 1211.9BRAF, KRAS
2regorafenib50 1210.9BRAF, KRAS
3o6-methylguanine449.9KRAS, BRAF
4cetuximab44 50 1211.8KRAS, BRAF
5crcs449.8KRAS, BRAF
6irinotecan44 50 1211.7KRAS, BRAF
7leucovorin44 50 1211.7KRAS, FASLG
8depsipeptide449.6FASLG, BRAF
9p002449.4BRAF, KRAS
10gold449.3FASLG, BRAF
11imatinib44 50 1211.3BRAF, FASLG, KRAS
12paclitaxel44 50 1211.3KRAS, BRAF, FASLG
13rapamycin449.2BRAF, FASLG, KRAS
14ly294002449.2FASLG, BRAF, KRAS
15wortmannin449.2FASLG, KRAS, BRAF
16calyculin a44 60 1211.2FASLG, PPP2R1B
17paraffin449.2FASLG, KRAS, BRAF
18cisplatin44 50 60 1212.1BRAF, FASLG, KRAS
19oligonucleotide449.0BRAF, FASLG, KRAS
20vegf449.0KRAS, BRAF, FASLG
21phosphatidylinositol448.9FASLG, KRAS, BRAF
22aspartate448.7PPP2R1B, BRAF, FASLG
23threonine448.4MAP3K8, BRAF, PPP2R1B
24serine448.0KRAS, BRAF, PPP2R1B, FASLG, MAP3K8

GO Terms for genes affiliated with Lung Cancer, Somatic

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Cellular components related to Lung Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.2KRAS, PPP2R1B

Biological processes related to Lung Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of gene expressionGO:0106289.5KRAS, BRAF
2MAPK cascadeGO:0001659.5KRAS, MAP3K8
3negative regulation of neuron apoptotic processGO:0435249.2KRAS, BRAF
4activation of MAPKK activityGO:0001869.1KRAS, MAP3K8, BRAF

Molecular functions related to Lung Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase kinase kinase activityGO:0047099.5MAP3K8, BRAF

Products for genes affiliated with Lung Cancer, Somatic

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Sources for Lung Cancer, Somatic

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet