MCID: LNG061
MIFTS: 26

Lung Cancer, Somatic malady

Genetic diseases (common), Respiratory diseases, Cancer diseases categories

Summaries for Lung Cancer, Somatic

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Sources:
48OMIM, 34MalaCards
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MalaCards: Lung Cancer, Somatic is related to lung cancer and nonsmall cell lung cancer, somatic. An important gene associated with Lung Cancer, Somatic is KRAS (Kirsten rat sarcoma viral oncogene homolog), and among its related pathways are Signaling by Interleukins and Toll-like receptor signaling pathway. The compounds panitumumab and regorafenib have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Description from OMIM:48 211980

Aliases & Classifications for Lung Cancer, Somatic

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Sources:
48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

lung cancer, somatic 48


Related Diseases for Lung Cancer, Somatic

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of diseases related to Lung Cancer, Somatic:



Diseases related to lung cancer, somatic

Symptoms for Lung Cancer, Somatic

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48OMIM
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Clinical features from OMIM:

211980

Drugs & Therapeutics for Lung Cancer, Somatic

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Lung Cancer, Somatic

Drug clinical trials:

Search ClinicalTrials for Lung Cancer, Somatic

Search NIH Clinical Center for Lung Cancer, Somatic

Search CenterWatch for Lung Cancer, Somatic

Genetic Tests for Lung Cancer, Somatic

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Anatomical Context for Lung Cancer, Somatic

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Sources:
34MalaCards
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MalaCards organs/tissues related to Lung Cancer, Somatic:

34
Lung

Animal Models for Lung Cancer, Somatic or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Lung Cancer, Somatic:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5KRAS, MAP3K8, BRAF
2MP:00020068.2KRAS, MAP3K8, BRAF

Publications for Lung Cancer, Somatic

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Variations for Lung Cancer, Somatic

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Lung Cancer, Somatic:

65
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Clinvar genetic disease variations for Lung Cancer, Somatic:

1
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> T (p.Gly12Cys)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
2FASLGNM_000639.1(FASLG): c.-844C=single nucleotide variantPathogenic, risk factorrs763110GRCh37Chr 1, 172627498: 172627498
3PPP2R1BNM_181699.2(PPP2R1B): c.269G> A (p.Gly90Asp)single nucleotide variantPathogenicrs1805076GRCh37Chr 11, 111635566: 111635566
4SLC22A18NM_183233.2(SLC22A18): c.698C> T (p.Ser233Phe)single nucleotide variantPathogenicrs121909071GRCh37Chr 11, 2939260: 2939260

Expression for genes affiliated with Lung Cancer, Somatic

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Cancer, Somatic

Search GEO for disease gene expression data for Lung Cancer, Somatic.

Pathways for genes affiliated with Lung Cancer, Somatic

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Sources:
51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 55R&D Systems, 61Thomson Reuters, 52PharmGKB, 62Tocris Bioscience, 5Cell Signaling Technology
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Pathways related to Lung Cancer, Somatic according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3KRAS, MAP3K8
2
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.3KRAS, MAP3K8
3
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.3KRAS, MAP3K8
4
Show member pathways
9.1KRAS, BRAF
5
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.1KRAS, BRAF
6
Show member pathways
9.1BRAF, KRAS
7
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
9.1KRAS, BRAF
8
Show member pathways
Signaling Pathways in Glioblastoma39
9.1BRAF, KRAS
99.1BRAF, KRAS
10
Show member pathways
Immune response CD16 signaling in NK cells61
9.1KRAS, BRAF
119.1KRAS, BRAF
12
Show member pathways
9.1KRAS, BRAF
13
Show member pathways
9.1KRAS, BRAF
14
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
9.1BRAF, KRAS
15
Show member pathways
9.1KRAS, BRAF
169.1KRAS, BRAF
17
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
9.1BRAF, KRAS
18
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.1KRAS, BRAF
19
Show member pathways
Signal transduction PTEN pathway61
9.1BRAF, KRAS
209.1BRAF, KRAS
21
Show member pathways
9.1BRAF, KRAS
229.1KRAS, BRAF
23
Show member pathways
9.1KRAS, BRAF
249.1KRAS, BRAF
259.1BRAF, KRAS
26
Show member pathways
9.1BRAF, KRAS
27
Show member pathways
9.1KRAS, BRAF
28
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.1KRAS, BRAF
29
Show member pathways
9.1KRAS, BRAF
30
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.1BRAF, KRAS
31
Show member pathways
9.1BRAF, KRAS
329.1KRAS, BRAF
33
Show member pathways
9.0MAP3K8, BRAF
34
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.0MAP3K8, BRAF
35
Show member pathways
MAPK signaling pathway39
8.5KRAS, MAP3K8, BRAF
36
Show member pathways
8.5KRAS, MAP3K8, BRAF

Compounds for genes affiliated with Lung Cancer, Somatic

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank
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Compounds related to Lung Cancer, Somatic according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1panitumumab46 52 1211.4KRAS, BRAF
2regorafenib52 1210.3KRAS, BRAF
3o6-methylguanine469.3BRAF, KRAS
4cetuximab46 52 1211.3KRAS, BRAF
5crcs469.2KRAS, BRAF
6irinotecan46 52 1211.2BRAF, KRAS
7p002469.1KRAS, BRAF
8imatinib46 52 1211.0KRAS, BRAF
9valine468.8BRAF, KRAS
10serine468.5KRAS, MAP3K8, BRAF

GO Terms for genes affiliated with Lung Cancer, Somatic

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Sources:
17Gene Ontology
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Biological processes related to Lung Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAPK cascadeGO:0001659.4KRAS, MAP3K8
2negative regulation of neuron apoptotic processGO:0435249.1BRAF, KRAS
3neurotrophin TRK receptor signaling pathwayGO:0480119.1KRAS, BRAF
4positive regulation of gene expressionGO:0106289.0KRAS, BRAF
5fibroblast growth factor receptor signaling pathwayGO:0085438.8KRAS, BRAF
6activation of MAPKK activityGO:0001868.6KRAS, MAP3K8, BRAF

Molecular functions related to Lung Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase kinase kinase activityGO:0047099.0MAP3K8, BRAF

Products for genes affiliated with Lung Cancer, Somatic

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lung Cancer, Somatic

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet