MCID: LNG063
MIFTS: 35

Lung Cancer Susceptibility malady

Respiratory diseases, Cancer diseases categories
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Summaries for Lung Cancer Susceptibility

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Wikipedia:65 Lung cancer susceptibility tests suggest the probability or susceptibility an individual may have of... more...

MalaCards based summary: Lung Cancer Susceptibility is related to lung cancer and lung cancer susceptibility 2. An important gene associated with Lung Cancer Susceptibility is LNCR1 (Lung cancer 1), and among its related pathways is Activation of Nicotinic Acetylcholine Receptors. The compounds alpha-conotoxin txia and alpha-conotoxin-gic have been mentioned in the context of this disorder. Affiliated tissues include lung and testes.

Aliases & Classifications for Lung Cancer Susceptibility

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Lung Cancer Susceptibility, Aliases & Descriptions:

Name: Lung Cancer Susceptibility 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


Related Diseases for Lung Cancer Susceptibility

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Diseases in the Lung Cancer Susceptibility 2 family:

Lung Cancer Susceptibility 5 Lung Cancer Susceptibility 3
Lung Cancer Susceptibility 4 lung cancer susceptibility

Diseases related to Lung Cancer Susceptibility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer32.2ERCC6, FASLG
2lung cancer susceptibility 230.9CHRNA3, CHRNA5
3lung cancer susceptibility 510.3
4lung cancer susceptibility 310.3
5lung cancer susceptibility 410.3
6nicotine dependence10.3CHRNA3, CHRNA5
7cocaine dependence10.3CHRNA3, CHRNA5
8chronic obstructive pulmonary disease10.2CHRNA3, CHRNA5
9silicosis10.1
10nasopharyngitis10.1
11melanoma10.1
12nicotine addiction10.1

Graphical network of diseases related to Lung Cancer Susceptibility:



Diseases related to lung cancer susceptibility

Symptoms for Lung Cancer Susceptibility

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Drugs & Therapeutics for Lung Cancer Susceptibility

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Drug clinical trials:

Search ClinicalTrials for Lung Cancer Susceptibility

Search NIH Clinical Center for Lung Cancer Susceptibility

Genetic Tests for Lung Cancer Susceptibility

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Anatomical Context for Lung Cancer Susceptibility

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MalaCards organs/tissues related to Lung Cancer Susceptibility:

32
Lung, Testes

Animal Models for Lung Cancer Susceptibility or affiliated genes

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Publications for Lung Cancer Susceptibility

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Articles related to Lung Cancer Susceptibility:

(show top 50)    (show all 160)
idTitleAuthorsYear
1
The association of c.1471G>A genetic polymorphism in XRCC1 gene with lung cancer susceptibility in Chinese Han population. (24519065)
2014
2
Correlation of CLPTM1L polymorphisms with lung cancer susceptibility and response to cisplatin-based chemotherapy in a Chinese Han population. (25155038)
2014
3
Association between TERT rs2736100 polymorphism and lung cancer susceptibility: evidence from 22 case-control studies. (24390616)
2014
4
Variants in phospholipid metabolism and upstream regulators and non-small cell lung cancer susceptibility. (23896864)
2014
5
Meta analysis of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia. (25066399)
2014
6
Suppressive Oligodeoxynucleotides Reduce Lung Cancer Susceptibility in Mice with Silicosis. (24403310)
2014
7
The relationship between genetic variants of XRCC1 gene and lung cancer susceptibility in Chinese Han population. (25146668)
2014
8
APE1 Asp148Glu polymorphism and lung cancer susceptibility. (24523018)
2014
9
Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. (23221128)
2013
10
Current evidences on IL1B polymorphisms and lung cancer susceptibility: a meta-analysis. (23784458)
2013
11
Associations between polymorphisms of the XPC gene and lung cancer susceptibility: a meta-analysis. (24375193)
2013
12
REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility. (22349819)
2013
13
CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinoma and smokers: a meta-analysis. (22952673)
2012
14
New lung cancer susceptibility locus identified: significance and implications for other genome-wide association studies. (22585853)
2012
15
Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans. (23232035)
2012
16
Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility. (22637743)
2012
17
Genetics of lung cancer susceptibility and COPD. (21708349)
2011
18
Polymorphisms in miRNA binding site: new insight into small cell lung cancer susceptibility. (21874042)
2011
19
HapMap-based study of a region encompassing ERCC1 and ERCC2 related to lung cancer susceptibility in a Chinese population. (21601580)
2011
20
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. (21725308)
2011
21
Sex differences in lung cancer susceptibility: a review. (21056866)
2010
22
Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans. (20587604)
2010
23
Polymorphism of cytochrome p450, glutathione-s-transferase and N-acetyltransferases: influence on lung cancer susceptibility. (20845626)
2010
24
A meta analysis on the relationship between myeloperoxidase G-463A genetic polymorphisms and lung cancer susceptibility]. (20673504)
2010
25
A polymorphism in the hMLH1 gene (-93G-->A) associated with lung cancer susceptibility and prognosis. (19956916)
2010
26
Association of DNA repair gene XRCC1 and lung cancer susceptibility among nonsmoking Chinese women. (19061777)
2009
27
Lung cancer susceptibility among atomic bomb survivors in relation to CA repeat number polymorphism of epidermal growth factor receptor gene and radiation dose. (19843645)
2009
28
Lung cancer susceptibility model based on age, family history and genetic variants. (19390575)
2009
29
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. (17510392)
2007
30
Relation between cytochrome P450 2D6 and lung cancer susceptibility caused by smoking]. (17424863)
2007
31
Combined effects of genetic polymorphisms in cytochrome P450s and GSTM1 on lung cancer susceptibility]. (18261353)
2007
32
Genetic polymorphisms of phase II metabolic enzymes and lung cancer susceptibility in a population of Central South China. (16788248)
2006
33
Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency. (16061637)
2005
34
'Comparison of extremes' approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibility. (15808403)
2005
35
Rapid detection of single nucleotide polymorphisms related with lung cancer susceptibility of Chinese population. (15896461)
2005
36
Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population. (15646021)
2004
37
Studies of the genes related to lung cancer susceptibility in Nanjing Han population, China]. (15640066)
2004
38
Association of L-myc polymorphism with lung cancer susceptibility and prognosis in relation to age-selected controls and stratified cases. (11955646)
2002
39
Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. (12205107)
2002
40
Modification of lung cancer susceptibility by green tea extract as measured by the comet assay. (12507225)
2002
41
A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility. (11691799)
2001
42
CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people. (11675150)
2001
43
Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility. (11266080)
2001
44
hOGG1 polymorphism and loss of heterozygosity (LOH): significance for lung cancer susceptibility in a caucasian population. (11093817)
2000
45
Is there a genetic basis for lung cancer susceptibility? (10337715)
1999
46
CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility]. (10921002)
1998
47
High frequency of interactions between lung cancer susceptibility genes in the mouse: mapping of Sluc5 to Sluc14. (9809979)
1998
48
Glutathione-S-Transferase M1 and codon 72 p53 polymorphisms in a northwestern Mediterranean population and their relation to lung cancer susceptibility. (9162298)
1996
49
Influence of a mutation reducing the catalytic activity of the cytochrome P450 CYP2D6 on lung cancer susceptibility. (8895499)
1996
50
CYP2D6 genotyping and the association with lung cancer susceptibility. (8081411)
1994

Variations for Lung Cancer Susceptibility

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Expression for genes affiliated with Lung Cancer Susceptibility

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Expression patterns in normal tissues for genes affiliated with Lung Cancer Susceptibility

Search GEO for disease gene expression data for Lung Cancer Susceptibility.

Pathways for genes affiliated with Lung Cancer Susceptibility

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Compounds for genes affiliated with Lung Cancer Susceptibility

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Sources:
28IUPHAR, 50PharmGKB, 44Novoseek, 11DrugBank
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Compounds related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alpha-conotoxin txia2810.3CHRNA3, CHRNA5
2alpha-conotoxin-gic2810.3CHRNA3, CHRNA5
3alpha-conotoxin pnia2810.3CHRNA3, CHRNA5
4alpha-conotoxin mii2810.2CHRNA3, CHRNA5
5drugs used in nicotine dependence5010.2CHRNA5, CHRNA3
6galantamine44 50 1112.1CHRNA3, CHRNA5
7leucovorin44 50 1112.1EGFR, FASLG
8topotecan44 1111.0EGFR, FASLG
9suberoylanilide hydroxamic acid449.8EGFR, FASLG

GO Terms for genes affiliated with Lung Cancer Susceptibility

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Cellular components related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.1CHRNA3, CHRNA5

Biological processes related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cation transportGO:00681210.1CHRNA3, CHRNA5
2behavioral response to nicotineGO:0350959.8CHRNA3, CHRNA5

Molecular functions related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-activated cation-selective channel activityGO:00488910.1CHRNA3, CHRNA5
2ligand-gated ion channel activityGO:01527610.0CHRNA3, CHRNA5
3acetylcholine receptor activityGO:0154649.8CHRNA3, CHRNA5

Products for genes affiliated with Lung Cancer Susceptibility

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  • Antibodies
  • Proteins
  • Lysates

Sources for Lung Cancer Susceptibility

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet