MCID: LNG063
MIFTS: 34

Lung Cancer Susceptibility malady

Respiratory diseases, Cancer diseases categories
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Summaries for Lung Cancer Susceptibility

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Lung cancer susceptibility tests suggest the probability or susceptibility an individual may have of... more...

MalaCards: Lung Cancer Susceptibility is related to lung cancer and lung cancer susceptibility 2. An important gene associated with Lung Cancer Susceptibility is LNCR1 (Lung cancer 1), and among its related pathways is Activation of Nicotinic Acetylcholine Receptors. The compounds alpha-conotoxin txia and alpha-conotoxin-gic have been mentioned in the context of this disorder. Affiliated tissues include lung and testes.

Aliases & Classifications for Lung Cancer Susceptibility

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47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

lung cancer susceptibility 47


Related Diseases for Lung Cancer Susceptibility

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Lung Cancer Susceptibility 2 family:

Lung Cancer Susceptibility 5 Lung Cancer Susceptibility 3
Lung Cancer Susceptibility 4 lung cancer susceptibility

Diseases related to Lung Cancer Susceptibility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer31.8ERCC6, FASLG
2lung cancer susceptibility 230.5CHRNA3, CHRNA5
3lung cancer susceptibility 310.3
4lung cancer susceptibility 410.3
5lung cancer susceptibility 510.2
6nicotine dependence10.1CHRNA3, CHRNA5
7silicosis10.1
8melanoma10.1
9nicotine addiction10.1
10cocaine dependence10.1CHRNA3, CHRNA5
11pulmonary disease, chronic obstructive10.0CHRNA3, CHRNA5

Graphical network of diseases related to Lung Cancer Susceptibility:



Diseases related to lung cancer susceptibility

Symptoms for Lung Cancer Susceptibility

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Drugs & Therapeutics for Lung Cancer Susceptibility

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Lung Cancer Susceptibility

Search NIH Clinical Center for Lung Cancer Susceptibility

Genetic Tests for Lung Cancer Susceptibility

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Anatomical Context for Lung Cancer Susceptibility

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33MalaCards
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MalaCards organs/tissues related to Lung Cancer Susceptibility:

33
Lung, Testes

Animal Models for Lung Cancer Susceptibility or affiliated genes

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Publications for Lung Cancer Susceptibility

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52PubMed
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Articles related to Lung Cancer Susceptibility:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Association between TERT rs2736100 polymorphism and lung cancer susceptibility: evidence from 22 case-control studies. (24390616)
2014
2
Variants in phospholipid metabolism and upstream regulators and non-small cell lung cancer susceptibility. (23896864)
2014
3
Suppressive Oligodeoxynucleotides Reduce Lung Cancer Susceptibility in Mice with Silicosis. (24403310)
2014
4
Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. (23221128)
2013
5
Current evidences on IL1B polymorphisms and lung cancer susceptibility: a meta-analysis. (23784458)
2013
6
Associations between polymorphisms of the XPC gene and lung cancer susceptibility: a meta-analysis. (24375193)
2013
7
Effects of PPP1R13L and CD3EAP variants on lung cancer susceptibility among nonsmoking Chinese women. (23624123)
2013
8
CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinoma and smokers: a meta-analysis. (22952673)
2012
9
New lung cancer susceptibility locus identified: significance and implications for other genome-wide association studies. (22585853)
2012
10
Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans. (23232035)
2012
11
Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility. (22637743)
2012
12
Genetics of lung cancer susceptibility and COPD. (21708349)
2011
13
Polymorphisms in miRNA binding site: new insight into small cell lung cancer susceptibility. (21874042)
2011
14
HapMap-based study of a region encompassing ERCC1 and ERCC2 related to lung cancer susceptibility in a Chinese population. (21601580)
2011
15
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. (21725308)
2011
16
Sex differences in lung cancer susceptibility: a review. (21056866)
2010
17
Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans. (20587604)
2010
18
Polymorphism of cytochrome p450, glutathione-s-transferase and N-acetyltransferases: influence on lung cancer susceptibility. (20845626)
2010
19
A meta analysis on the relationship between myeloperoxidase G-463A genetic polymorphisms and lung cancer susceptibility]. (20673504)
2010
20
A polymorphism in the hMLH1 gene (-93G-->A) associated with lung cancer susceptibility and prognosis. (19956916)
2010
21
Lung Cancer Susceptibility and hOGG1 Ser326Cys Polymorphism: A Meta-Analysis. (24281202)
2010
22
Polymorphisms in the microsomal epoxide hydrolase gene: role in lung cancer susceptibility and prognosis. (21302624)
2010
23
Association of DNA repair gene XRCC1 and lung cancer susceptibility among nonsmoking Chinese women. (19061777)
2009
24
Lung cancer susceptibility among atomic bomb survivors in relation to CA repeat number polymorphism of epidermal growth factor receptor gene and radiation dose. (19843645)
2009
25
Lung cancer susceptibility model based on age, family history and genetic variants. (19390575)
2009
26
Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility. (19285750)
2009
27
The feasibility of online genetic testing for lung cancer susceptibility: uptake of a web-based protocol and decision outcomes. (18281920)
2008
28
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. (17510392)
2007
29
Relation between cytochrome P450 2D6 and lung cancer susceptibility caused by smoking]. (17424863)
2007
30
Combined effects of genetic polymorphisms in cytochrome P450s and GSTM1 on lung cancer susceptibility]. (18261353)
2007
31
Genetic polymorphisms of phase II metabolic enzymes and lung cancer susceptibility in a population of Central South China. (16788248)
2006
32
Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency. (16061637)
2005
33
'Comparison of extremes' approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibility. (15808403)
2005
34
Rapid detection of single nucleotide polymorphisms related with lung cancer susceptibility of Chinese population. (15896461)
2005
35
Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population. (15646021)
2004
36
Studies of the genes related to lung cancer susceptibility in Nanjing Han population, China]. (15640066)
2004
37
Smoking and the risk of lung cancer: susceptibility with GSTP1 polymorphisms. (14501269)
2003
38
Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. (12205107)
2002
39
Modification of lung cancer susceptibility by green tea extract as measured by the comet assay. (12507225)
2002
40
A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility. (11691799)
2001
41
CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people. (11675150)
2001
42
Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility. (11266080)
2001
43
Lung cancer susceptibility in relation to combined polymorphisms of microsomal epoxide hydrolase and glutathione S-transferase P1. (11597790)
2001
44
hOGG1 polymorphism and loss of heterozygosity (LOH): significance for lung cancer susceptibility in a caucasian population. (11093817)
2000
45
Is there a genetic basis for lung cancer susceptibility? (10337715)
1999
46
CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility]. (10921002)
1998
47
High frequency of interactions between lung cancer susceptibility genes in the mouse: mapping of Sluc5 to Sluc14. (9809979)
1998
48
Glutathione-S-Transferase M1 and codon 72 p53 polymorphisms in a northwestern Mediterranean population and their relation to lung cancer susceptibility. (9162298)
1996
49
Influence of a mutation reducing the catalytic activity of the cytochrome P450 CYP2D6 on lung cancer susceptibility. (8895499)
1996
50
CYP2D6 genotyping and the association with lung cancer susceptibility. (8081411)
1994

Variations for Lung Cancer Susceptibility

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Expression for genes affiliated with Lung Cancer Susceptibility

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Cancer Susceptibility

Search GEO for disease gene expression data for Lung Cancer Susceptibility.

Pathways for genes affiliated with Lung Cancer Susceptibility

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50PathCards, 55Reactome
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Compounds for genes affiliated with Lung Cancer Susceptibility

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29IUPHAR, 51PharmGKB, 45Novoseek, 11DrugBank
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Compounds related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alpha-conotoxin txia2910.3CHRNA3, CHRNA5
2alpha-conotoxin-gic2910.3CHRNA3, CHRNA5
3alpha-conotoxin pnia2910.3CHRNA3, CHRNA5
4alpha-conotoxin mii2910.2CHRNA3, CHRNA5
5drugs used in nicotine dependence5110.2CHRNA5, CHRNA3
6galantamine45 51 1112.1CHRNA3, CHRNA5
7leucovorin45 51 1112.1EGFR, FASLG
8topotecan45 1111.0EGFR, FASLG
9suberoylanilide hydroxamic acid459.8EGFR, FASLG

GO Terms for genes affiliated with Lung Cancer Susceptibility

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16Gene Ontology
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Cellular components related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.1CHRNA3, CHRNA5

Biological processes related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cation transportGO:00681210.1CHRNA3, CHRNA5
2behavioral response to nicotineGO:0350959.8CHRNA3, CHRNA5

Molecular functions related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-activated cation-selective channel activityGO:00488910.1CHRNA3, CHRNA5
2ligand-gated ion channel activityGO:01527610.0CHRNA3, CHRNA5
3acetylcholine receptor activityGO:0154649.8CHRNA3, CHRNA5

Products for genes affiliated with Lung Cancer Susceptibility

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lung Cancer Susceptibility

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet