MCID: LNG063
MIFTS: 38

Lung Cancer Susceptibility malady

Respiratory diseases, Cancer diseases categories

Summaries for Lung Cancer Susceptibility

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Lung cancer susceptibility tests suggest the probability or susceptibility an individual may have of... more...

MalaCards: Lung Cancer Susceptibility is related to lung cancer and lung cancer susceptibility 2. An important gene associated with Lung Cancer Susceptibility is LNCR1 (Lung cancer 1), and among its related pathways are Naphthalene metabolism and Drug metabolism - cytochrome P450. The compounds 1-hydroxypyrene and mspi have been mentioned in the context of this disorder. Affiliated tissues include lung and testes, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Lung Cancer Susceptibility

About this section
Sources:
46OMIM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

lung cancer susceptibility 46


Related Diseases for Lung Cancer Susceptibility

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Lung Cancer Susceptibility 2 family:

Lung Cancer Susceptibility 5 Lung Cancer Susceptibility 3
Lung Cancer Susceptibility 4 lung cancer susceptibility

Diseases related to Lung Cancer Susceptibility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer31.7OGG1, EGFR, CYP1A1, CYP2E1, GSTM1
2lung cancer susceptibility 230.4CHRNA3, CHRNA5
3squamous cell carcinoma30.1OGG1, EGFR, EPHX1, CYP1A1, CYP2E1, ERCC2
4lung cancer susceptibility 310.3
5lung cancer susceptibility 410.3
6lung cancer susceptibility 510.2
7silicosis10.0
8lung squamous cell carcinoma10.0
9melanoma10.0
10bladder carcinoma10.0OGG1, EGFR, EPHX1, CYP1A1, CYP2E1, ERCC2
11adenocarcinoma10.0OGG1, EGFR, EPHX1, CYP1A1, CYP2E1, ERCC2
12non-hodgkin lymphoma10.0OGG1, EPHX1, CYP1A1, CYP2E1, ERCC2, GSTM1
13pulmonary disease, chronic obstructive10.0SOD3, EPHX1, CYP1A1, CYP2E1, GSTM1, GSTT1
14lung adenocarcinoma10.0OGG1, EGFR, CYP1A1, CYP2E1, GSTM1, GSTT1
15leukemia10.0OGG1, EPHX1, CYP1A1, CYP2E1, ERCC2, GSTM1
16adenoma10.0OGG1, EPHX1, CYP1A1, ERCC2, GSTM1, GSTT1
17hepatocellular carcinoma10.0OGG1, EPHX1, CYP1A1, CYP2E1, GSTM1, GSTT1
18stomach cancer10.0OGG1, EGFR, CYP1A1, CYP2E1, GSTM1, GSTT1
19oral cancer10.0EGFR, CYP1A1, CYP2E1, GSTM1, GSTT1
20nasopharynx carcinoma10.0EGFR, CYP1A1, CYP2E1, GSTM1, GSTT1
21ovarian cancer10.0OGG1, EGFR, EPHX1, ERCC2, GSTT1
22squamous cell carcinoma of the head and neck10.0GSTT1, GSTM1, CYP1A1, EGFR, OGG1
23laryngeal squamous cell carcinoma10.0EGFR, CYP1A1, CYP2E1, GSTM1, GSTT1
24lung small cell carcinoma10.0OGG1, EGFR, CYP1A1, GSTM1, GSTT1
25colon cancer10.0OGG1, EGFR, EPHX1, CYP1A1, GSTM1, GSTT1
26cervical cancer10.0EGFR, CYP1A1, GSTM1, GSTT1
27acute lymphoblastic leukemia, childhood10.0CYP1A1, CYP2E1, GSTM1, GSTT1
28basal cell carcinoma10.0GSTT1, GSTM1, ERCC2, CYP1A1
29malignant glioma10.0GSTT1, ERCC2, CYP1A1, EPHX1, EGFR
30non-small cell lung carcinoma10.0OGG1, EGFR, CYP2E1, GSTM1
31xeroderma pigmentosum10.0OGG1, CYP1A1, ERCC2, GSTT1
32cork-handlers' disease10.0GSTT1, CYP2E1, EPHX1, SOD3
33alzheimer's disease10.0GSTT1, GSTM1, CYP2E1, OGG1
34leukoplakia10.0CYP1A1, GSTM1, GSTT1
35endometriosis10.0GSTT1, GSTM1, CYP1A1
36brain cancer10.0CYP1A1, GSTM1, GSTT1
37acute leukemia10.0GSTT1, GSTM1, OGG1
38prostate cancer10.0EGFR, CYP2E1, GSTM1, GSTT1
39acute myeloid leukemia, adult10.0GSTT1, GSTM1, CYP1A1
40bladder carcinoma in situ10.0EGFR, ERCC2, GSTM1
41pneumonia10.0GSTM1, CYP1A1, SOD3
42asthma10.0EPHX1, CYP2E1, GSTM1, GSTT1
43aplastic anemia10.0EPHX1, GSTM1, GSTT1
44esophageal cancer10.0CYP2E1, EGFR
45laryngeal benign neoplasm10.0GSTT1, EGFR
46colorectal cancer10.0OGG1, EGFR, EPHX1, CYP1A1
47asbestosis10.0GSTT1, GSTM1
48thyroid cancer10.0GSTM1, GSTT1
49transitional cell carcinoma10.0EGFR, GSTM1, GSTT1
50nicotine dependence10.0CHRNA5, CHRNA3

Graphical network of the top 20 diseases related to Lung Cancer Susceptibility:



Diseases related to lung cancer susceptibility

Clinical Features for Lung Cancer Susceptibility

About this section

Drugs & Therapeutics for Lung Cancer Susceptibility

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Lung Cancer Susceptibility

Drug clinical trials:

Search ClinicalTrials for Lung Cancer Susceptibility

Search NIH Clinical Center for Lung Cancer Susceptibility

Search CenterWatch for Lung Cancer Susceptibility

Genetic Tests for Lung Cancer Susceptibility

About this section

Anatomical Context for Lung Cancer Susceptibility

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Lung Cancer Susceptibility:

32
Lung, Testes

Animal Models for Lung Cancer Susceptibility or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Lung Cancer Susceptibility:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.1GSTT1, ERCC2, EPHX1, CHRNA3, SOD3

Publications for Lung Cancer Susceptibility

About this section

Genetic Variations for Lung Cancer Susceptibility

About this section

Expression for genes affiliated with Lung Cancer Susceptibility

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lung Cancer Susceptibility

Search GEO for disease gene expression data for Lung Cancer Susceptibility.

Pathways for genes affiliated with Lung Cancer Susceptibility

About this section
Sources:
12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 53Reactome, 49PharmGKB
See all sources

Pathways related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Naphthalene metabolism
Hide members
11.1GSTT1, GSTM1, CYP2E1, CYP1A1, EPHX1
2
Hide members
11.1EPHX1, CYP1A1, CYP2E1, GSTM1, GSTT1
3
Hide members
11.1EPHX1, CYP1A1, CYP2E1, GSTM1, GSTT1
4
Acetaminophen metabolism
Hide members
10.9CYP2E1, CYP1A1, EPHX1
510.9GSTT1, GSTM1, EPHX1
6
Hide members
10.7CHRNA5, CHRNA3
7
Hide members
10.7EGFR, CYP1A1
810.7GSTT1, GSTM1
9
Hide members
10.7CYP1A1, EPHX1

Compounds for genes affiliated with Lung Cancer Susceptibility

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
11-hydroxypyrene4411.7CYP2E1, OGG1, EPHX1, CYP1A1, GSTT1, GSTM1
2mspi4411.7GSTM1, GSTT1, CYP1A1, ERCC2, CYP2E1, EPHX1
3oxaliplatin44 49 1113.7CYP1A1, CYP2E1, ERCC2, GSTM1, EGFR, GSTT1
4ascorbic acid44 2412.6CYP2E1, SOD3, CYP1A1, GSTT1, GSTM1, OGG1
5benzene4411.6OGG1, GSTT1, EPHX1, GSTM1, CYP2E1
6hydrocarbons4411.5ERCC2, EPHX1, CYP1A1, GSTT1, GSTM1
7gsts4411.5CYP2E1, EPHX1, CYP1A1, GSTM1, GSTT1
8epoxide4411.5EPHX1, CYP1A1, CYP2E1, GSTM1, GSTT1
9cyclophosphamide44 49 1113.5CYP2E1, GSTT1, GSTM1, ERCC2, CYP1A1
10folate4411.5OGG1, ERCC2, SOD3, GSTT1, GSTM1
11ethylene oxide4411.4OGG1, EPHX1, GSTM1, GSTT1
12butadiene monoxide4411.4EPHX1, GSTT1, GSTM1, CYP2E1
131,3-butadiene4411.4CYP2E1, EPHX1, GSTM1, GSTT1
14styrene4411.4EPHX1, GSTT1, GSTM1, CYP2E1
15cotinine44 2412.4GSTT1, ERCC2, OGG1, GSTM1
16acetone4411.4CYP1A1, CYP2E1, GSTM1, GSTT1
17benzo(a)pyrene4411.4GSTM1, CYP1A1, EPHX1, GSTT1
18betacarotene4411.4GSTM1, CYP2E1, CYP1A1, EGFR
19malondialdehyde4411.3OGG1, SOD3, GSTM1, GSTT1
20phenobarbital44 28 1113.3GSTM1, CYP2E1, CYP1A1, EPHX1
21trans,trans-muconic acid4411.3CYP2E1, GSTT1, GSTM1
22s-phenylmercapturic acid4411.3GSTT1, CYP2E1, GSTM1
23styrene oxide4411.3GSTM1, GSTT1, EPHX1
24vinylchloride4411.3GSTM1, GSTT1, CYP2E1
25arylamine4411.2EPHX1, GSTM1, GSTT1
26diepoxybutane4411.2EPHX1, GSTM1, GSTT1
27toluene4411.2GSTT1, GSTM1, CYP2E1
28trichloroethylene4411.2CYP2E1, GSTM1, GSTT1
29debrisoquine4411.2GSTM1, CYP2E1, CYP1A1
30nadph44 2412.2OGG1, SOD3, EPHX1
31benzidine4411.2GSTM1, EPHX1, GSTT1
328-oxoguanine4411.2OGG1, GSTT1, GSTM1
338-oxo-dg4411.2OGG1, GSTM1, GSTT1
34bpde4411.2CYP1A1, EPHX1
35isoniazid49 44 1113.1GSTT1, GSTM1, CYP2E1
36aflatoxin b144 2412.1GSTT1, GSTM1, EPHX1
37oxygen44 2412.1OGG1, SOD3, CYP1A1, GSTM1
38manganese superoxide4411.1GSTT1, SOD3
39rsai4411.1GSTM1, CYP2E1, GSTT1
40bcnu4411.0GSTT1, ERCC2, EGFR
41α-conotoxin-gic2811.0CHRNA3, CHRNA5
42α-conotoxin pnia2811.0CHRNA3, CHRNA5
43benzo(a)pyrene-trans-7,8-dihydrodiol4411.0EPHX1, CYP1A1
44α-conotoxin txia2811.0CHRNA5, CHRNA3
45α-conotoxin mii2810.8CHRNA3, CHRNA5
46benzeneoxide4410.8EPHX1, CYP2E1
47gamma-glutamylcysteine44 11 2412.8SOD3, EPHX1, GSTM1
48n-(2-hydroxyethyl)valine4410.7GSTM1, GSTT1
49drugs for treatment of tuberculosis4910.7GSTT1, GSTM1
50methylchloride4410.4GSTM1, GSTT1

GO Terms for genes affiliated with Lung Cancer Susceptibility

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.7CHRNA5, CHRNA3

Biological processes related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:00680511.1GSTT1, GSTM1, CYP2E1, CYP1A1
2response to drugGO:04249311.0GSTT1, CYP2E1, CYP1A1, OGG1
3response to organic cyclic compoundGO:01407010.9GSTT1, CYP1A1, EPHX1
4behavioral response to nicotineGO:03509510.6CHRNA3, CHRNA5
5nucleotide-excision repairGO:00628910.6ERCC2, OGG1, RPA4

Molecular functions related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:01989911.0GSTM1, CYP2E1, CYP1A1, EGFR
2acetylcholine-activated cation-selective channel activityGO:00488910.7CHRNA5, CHRNA3
3ligand-gated ion channel activityGO:01527610.6CHRNA3, CHRNA5
4acetylcholine receptor activityGO:01546410.4CHRNA5, CHRNA3

Products for genes affiliated with Lung Cancer Susceptibility

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lung Cancer Susceptibility

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet