MCID: LNG063
MIFTS: 42

Lung Cancer Susceptibility malady

Respiratory, Cancer categories

Summaries for Lung Cancer Susceptibility

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Lung cancer susceptibility tests show that the probability of getting lung cancer is high. Lung cancer... more...

MalaCards: Lung Cancer Susceptibility is related to lung cancer susceptibility 2 and squamous cell carcinoma. An important gene associated with Lung Cancer Susceptibility is LNCR1 (Lung cancer 1), and among its related pathways are Naphthalene metabolism and Drug metabolism - cytochrome P450. The compounds 1-hydroxypyrene and mspi have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and breast, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Lung Cancer Susceptibility

Sources:
47OMIM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Respiratory


Aliases & Descriptions:

lung cancer susceptibility 47


Related Diseases for Lung Cancer Susceptibility

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the lung cancer susceptibility 2 family:

lung cancer susceptibility 5 lung cancer susceptibility 3
lung cancer susceptibility 4 lung cancer susceptibility

Diseases related to Lung Cancer Susceptibility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer susceptibility 230.7CHRNA3, CHRNA5
2squamous cell carcinoma30.1OGG1, EGFR, EPHX1, CYP1A1, CYP2E1, ERCC2
3oral cancer30.1EGFR, CYP1A1, CYP2E1, GSTM1, GSTT1
4lung cancer susceptibility 510.5
5lung cancer susceptibility 410.5
6lung cancer susceptibility 310.4
7silicosis10.1
8nicotine addiction10.1
9bladder carcinoma10.0OGG1, EGFR, EPHX1, CYP1A1, CYP2E1, ERCC2
10adenocarcinoma10.0OGG1, EGFR, EPHX1, CYP1A1, CYP2E1, ERCC2
11non-hodgkin lymphoma10.0OGG1, EPHX1, CYP1A1, CYP2E1, ERCC2, GSTM1
12pulmonary disease, chronic obstructive10.0SOD3, EPHX1, CYP1A1, CYP2E1, GSTM1, GSTT1
13lung adenocarcinoma10.0OGG1, EGFR, CYP1A1, CYP2E1, GSTM1, GSTT1
14leukemia10.0OGG1, EPHX1, CYP1A1, CYP2E1, ERCC2, GSTM1
15adenoma10.0OGG1, EPHX1, CYP1A1, ERCC2, GSTM1, GSTT1
16hepatocellular carcinoma10.0OGG1, EPHX1, CYP1A1, CYP2E1, GSTM1, GSTT1
17stomach cancer10.0OGG1, EGFR, CYP1A1, CYP2E1, GSTM1, GSTT1
18nasopharynx carcinoma10.0EGFR, CYP1A1, CYP2E1, GSTM1, GSTT1
19ovarian cancer10.0OGG1, EGFR, EPHX1, ERCC2, GSTT1
20squamous cell carcinoma of the head and neck10.0GSTT1, GSTM1, CYP1A1, EGFR, OGG1
21laryngeal squamous cell carcinoma10.0EGFR, CYP1A1, CYP2E1, GSTM1, GSTT1
22lung small cell carcinoma10.0OGG1, EGFR, CYP1A1, GSTM1, GSTT1
23colon cancer10.0OGG1, EGFR, EPHX1, CYP1A1, GSTM1, GSTT1
24lung cancer10.0OGG1, EGFR, CYP1A1, CYP2E1, GSTM1
25cervical cancer10.0EGFR, CYP1A1, GSTM1, GSTT1
26acute lymphoblastic leukemia, childhood10.0CYP1A1, CYP2E1, GSTM1, GSTT1
27basal cell carcinoma10.0GSTT1, GSTM1, ERCC2, CYP1A1
28malignant glioma10.0GSTT1, ERCC2, CYP1A1, EPHX1, EGFR
29non-small cell lung carcinoma10.0OGG1, EGFR, CYP2E1, GSTM1
30xeroderma pigmentosum10.0OGG1, CYP1A1, ERCC2, GSTT1
31cork-handlers' disease10.0GSTT1, CYP2E1, EPHX1, SOD3
32alzheimer's disease10.0GSTT1, GSTM1, CYP2E1, OGG1
33leukoplakia10.0CYP1A1, GSTM1, GSTT1
34endometriosis10.0GSTT1, GSTM1, CYP1A1
35brain cancer10.0CYP1A1, GSTM1, GSTT1
36skin cancer10.0OGG1, CYP1A1, ERCC2
37acute leukemia10.0GSTT1, GSTM1, OGG1
38prostate cancer10.0EGFR, CYP2E1, GSTM1, GSTT1
39acute myeloid leukemia, adult10.0GSTT1, GSTM1, CYP1A1
40bladder carcinoma in situ10.0EGFR, ERCC2, GSTM1
41pneumonia10.0GSTM1, CYP1A1, SOD3
42asthma10.0EPHX1, CYP2E1, GSTM1, GSTT1
43aplastic anemia10.0EPHX1, GSTM1, GSTT1
44esophageal cancer10.0CYP2E1, EGFR
45laryngeal carcinoma10.0GSTT1, EGFR
46colorectal cancer10.0OGG1, EGFR, EPHX1, CYP1A1
47asbestosis10.0GSTT1, GSTM1
48thyroid cancer10.0GSTM1, GSTT1
49transitional cell carcinoma10.0EGFR, GSTM1, GSTT1
50nicotine dependence10.0CHRNA5, CHRNA3

Graphical network of the top 20 diseases related to Lung Cancer Susceptibility:



Diseases related to lung cancer susceptibility

Clinical Features for Lung Cancer Susceptibility

Drugs & Therapeutics for Lung Cancer Susceptibility

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Lung Cancer Susceptibility

Drug clinical trials:

Search ClinicalTrials for Lung Cancer Susceptibility

Search NIH Clinical Center for Lung Cancer Susceptibility

Search CenterWatch for Lung Cancer Susceptibility

Genetic Tests for Lung Cancer Susceptibility

Anatomical Context for Lung Cancer Susceptibility

Sources:
33MalaCards
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MalaCards organs/tissues related to Lung Cancer Susceptibility:

33
Lymph node, Lung, Breast, Myeloid, B cells

Animal Models for Lung Cancer Susceptibility or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Lung Cancer Susceptibility:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.1GSTT1, ERCC2, EPHX1, CHRNA3, SOD3

Publications for Lung Cancer Susceptibility

Sources:
51PubMed
See all sources

Articles related to Lung Cancer Susceptibility:

(show top 50)    (show all 273)
idTitleAuthorsYear
1
Variants in phospholipid metabolism and upstream regulators and non-small cell lung cancer susceptibility. (23896864)
2014
2
Effects of PPP1R13L and CD3EAP variants on lung cancer susceptibility among nonsmoking Chinese women. (23624123)
2013
3
The association between TP53 Arg72Pro polymorphism and lung cancer susceptibility: evidence from 30,038 subjects. (23595658)
2013
4
Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls. (23370545)
2013
5
Lack of association of C-Met-N375S sequence variant with lung cancer susceptibility and prognosis. (23801885)
2013
6
Polymorphisms in GSTM1, CYP1A1, CYP2E1, and CYP2D6 are associated with susceptibility and chemotherapy response in non-small-cell lung cancer patients. (22109568)
2012
7
Association of ERCC2/XPD polymorphisms and interaction with tobacco smoking in lung cancer susceptibility: a systemic review and meta-analysis. (21614524)
2012
8
Association of hypoxia inducible factor-1I+ polymorphisms with susceptibility to non-small-cell lung cancer. (22153809)
2012
9
The hOGG1Ser326Cys polymorphism and increased lung cancer susceptibility in Caucasians: an updated meta-analysis. (22855704)
2012
10
Correlation between polymorphisms of nicotine acetylcholine acceptor subunit CHRNA3 and lung cancer susceptibility. (23023782)
2012
11
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. (23143601)
2012
12
HapMap-based study of a region encompassing ERCC1 and ERCC2 related to lung cancer susceptibility in a Chinese population. (21601580)
2011
13
CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis based on 32 studies. (22025136)
2011
14
Association of miR-605 and miR-149 genetic polymorphisms with related risk factors of lung cancer susceptibility]. (21671485)
2011
15
STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer. (21948749)
2011
16
Association between insulin-like growth factor binding protein-3 promoter polymorphism of -1590 C>A and lung cancer susceptibility in a Chinese Han population. (21254935)
2011
17
Polymorphism of cytochrome p450, glutathione-s-transferase and N-acetyltransferases: influence on lung cancer susceptibility. (20845626)
2010
18
The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema. (20007924)
2010
19
Genetic susceptibility of lung cancer associated with common variants in the 3' untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export. (19107762)
2009
20
Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility. (19285750)
2009
21
MUTYH Gln324His gene polymorphism and genetic susceptibility for lung cancer in a Japanese population. (19161591)
2009
22
Activation of ER stress and inhibition of EGFR N-glycosylation by tunicamycin enhances susceptibility of human non-small cell lung cancer cells to erlotinib. (19130057)
2009
23
A polymorphism in the angiogenesis inhibitor, endostatin, in lung cancer susceptibility. (18054814)
2008
24
Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers. (18449888)
2008
25
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. (18385738)
2008
26
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. (17510392)
2007
27
Genetic polymorphisms of phase II metabolic enzymes and lung cancer susceptibility in a population of Central South China. (16788248)
2006
28
Surfactant protein B gene variations and susceptibility to lung cancer in chromate workers. (16570259)
2006
29
Association of MMP1 -1607(1G>2G)single nucleotide polymorphism with susceptibility to lung cancer in Northwestern Chinese population of Han nationality]. (16767672)
2006
30
Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer. (17052295)
2006
31
Relationship between LAPTM4B gene polymorphism and susceptibility of lung cancer]. (15968325)
2005
32
Green tea consumption, genetic susceptibility, PAH-rich smoky coal, and the risk of lung cancer. (15781210)
2005
33
Studies of the genes related to lung cancer susceptibility in Nanjing Han population, China]. (15640066)
2004
34
p53 gene polymorphism with susceptibility to esophageal cancer and lung cancer in Chinese population]. (12921568)
2003
35
Restoration of CD44S in non-small cell lung cancer cells enhanced their susceptibility to the macrophage cytotoxicity. (12871777)
2003
36
Cyclin D1 gene polymorphism and susceptibility to lung cancer in a Chinese population. (12807740)
2003
37
Correspondence re: Feyler et al., Point: Myeloperoxidase (-463)G --> a polymorphism and lung cancer risk. Cancer Epidemiol. Biomark. Prev., 11: 1550-1554, 2002, and Xu et al., Counterpoint: The myeloperoxidase (-463)G --> a polymorphism does not decrease lung cancer susceptibility in Caucasians. 11: 1555-1559, 2002. (12869414)
2003
38
p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity. (11983757)
2002
39
Glutathione-S-transferase M1, M3, T1 and P1 polymorphisms and susceptibility to non-small-cell lung cancer subtypes and hamartomas. (11740339)
2001
40
Maximizing the motivational impact of feedback of lung cancer susceptibility on smokers' desire to quit. (11185023)
2000
41
Is there a genetic basis for lung cancer susceptibility? (10337715)
1999
42
Polymorphisms of the GSTM1 and CYP2D6 genes associated with susceptibility to lung cancer in Chinese. (10521684)
1999
43
hOGG1 Ser326Cys polymorphism and lung cancer susceptibility. (10744126)
1999
44
Combined effect of polymorphic GST genes on individual susceptibility to lung cancer. (9679751)
1998
45
CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility]. (10921002)
1998
46
Polymorphisms in the glutathione S-transferase class mu and theta genes interact and increase susceptibility to lung cancer in minority populations (Texas, United States). (9242470)
1997
47
A case-control study of cytochrome P450 1A1, glutathione S-transferase M1, cigarette smoking and lung cancer susceptibility (Massachusetts, United States) (9242469)
1997
48
A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility. (8895751)
1996
49
Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer: possible relevance to low smoking exposure. (7915935)
1994
50
Association between restriction fragment length polymorphism of the human cytochrome P450IIE1 gene and susceptibility to lung cancer. (1673675)
1991

Genetic Variations for Lung Cancer Susceptibility

Expression for genes affiliated with Lung Cancer Susceptibility

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lung Cancer Susceptibility

Search GEO for disease gene expression data for Lung Cancer Susceptibility.

Pathways for genes affiliated with Lung Cancer Susceptibility

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 54Reactome, 50PharmGKB
See all sources

Pathways related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Naphthalene metabolism
Hide members
11.1CYP2E1, EPHX1, CYP1A1, GSTM1, GSTT1
2
Hide members
11.1GSTT1, GSTM1, CYP2E1, CYP1A1, EPHX1
3
Hide members
11.1GSTM1, GSTT1, EPHX1, CYP1A1, CYP2E1
4
Acetaminophen metabolism
Hide members
10.9EPHX1, CYP1A1, CYP2E1
510.9GSTT1, EPHX1, GSTM1
6
Hide members
10.7CHRNA5, CHRNA3
7
Hide members
10.7EGFR, CYP1A1
810.7GSTT1, GSTM1
9
Hide members
10.7CYP1A1, EPHX1

Compounds for genes affiliated with Lung Cancer Susceptibility

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
See all sources

Compounds related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
11-hydroxypyrene4511.7CYP2E1, OGG1, EPHX1, CYP1A1, GSTT1, GSTM1
2mspi4511.7GSTM1, GSTT1, CYP1A1, ERCC2, CYP2E1, EPHX1
3oxaliplatin45 50 1113.7CYP1A1, CYP2E1, ERCC2, GSTM1, EGFR, GSTT1
4ascorbic acid45 2412.6CYP2E1, SOD3, CYP1A1, GSTT1, GSTM1, OGG1
5benzene4511.6OGG1, GSTT1, EPHX1, GSTM1, CYP2E1
6hydrocarbons4511.5ERCC2, EPHX1, CYP1A1, GSTT1, GSTM1
7gsts4511.5CYP2E1, EPHX1, CYP1A1, GSTM1, GSTT1
8epoxide4511.5EPHX1, CYP1A1, CYP2E1, GSTM1, GSTT1
9cyclophosphamide45 50 1113.5CYP2E1, GSTT1, GSTM1, ERCC2, CYP1A1
10folate4511.5OGG1, ERCC2, SOD3, GSTT1, GSTM1
11ethylene oxide4511.4OGG1, EPHX1, GSTM1, GSTT1
12butadiene monoxide4511.4EPHX1, GSTT1, GSTM1, CYP2E1
131,3-butadiene4511.4CYP2E1, EPHX1, GSTM1, GSTT1
14styrene4511.4EPHX1, GSTT1, GSTM1, CYP2E1
15cotinine45 2412.4GSTT1, ERCC2, OGG1, GSTM1
16acetone4511.4CYP1A1, CYP2E1, GSTM1, GSTT1
17benzo(a)pyrene4511.4GSTM1, CYP1A1, EPHX1, GSTT1
18betacarotene4511.4GSTM1, CYP2E1, CYP1A1, EGFR
19malondialdehyde4511.3OGG1, SOD3, GSTM1, GSTT1
20phenobarbital45 29 1113.3GSTM1, CYP2E1, CYP1A1, EPHX1
21trans,trans-muconic acid4511.3CYP2E1, GSTT1, GSTM1
22s-phenylmercapturic acid4511.3GSTT1, CYP2E1, GSTM1
23styrene oxide4511.3GSTM1, GSTT1, EPHX1
24vinylchloride4511.3GSTM1, GSTT1, CYP2E1
25arylamine4511.2EPHX1, GSTM1, GSTT1
26diepoxybutane4511.2EPHX1, GSTM1, GSTT1
27toluene4511.2GSTT1, GSTM1, CYP2E1
28trichloroethylene4511.2CYP2E1, GSTM1, GSTT1
29debrisoquine4511.2GSTM1, CYP2E1, CYP1A1
30nadph45 2412.2OGG1, SOD3, EPHX1
31benzidine4511.2GSTM1, EPHX1, GSTT1
328-oxoguanine4511.2OGG1, GSTT1, GSTM1
338-oxo-dg4511.2OGG1, GSTM1, GSTT1
34bpde4511.2CYP1A1, EPHX1
35isoniazid50 45 1113.1GSTT1, GSTM1, CYP2E1
36aflatoxin b145 2412.1GSTT1, GSTM1, EPHX1
37oxygen45 2412.1OGG1, SOD3, CYP1A1, GSTM1
38manganese superoxide4511.1GSTT1, SOD3
39rsai4511.1GSTM1, CYP2E1, GSTT1
40bcnu4511.0GSTT1, ERCC2, EGFR
41α-conotoxin-gic2911.0CHRNA3, CHRNA5
42α-conotoxin pnia2911.0CHRNA3, CHRNA5
43benzo(a)pyrene-trans-7,8-dihydrodiol4511.0EPHX1, CYP1A1
44α-conotoxin txia2911.0CHRNA5, CHRNA3
45α-conotoxin mii2910.8CHRNA3, CHRNA5
46benzeneoxide4510.8EPHX1, CYP2E1
47gamma-glutamylcysteine45 11 2412.8SOD3, EPHX1, GSTM1
48n-(2-hydroxyethyl)valine4510.7GSTM1, GSTT1
49drugs for treatment of tuberculosis5010.7GSTT1, GSTM1
50methylchloride4510.4GSTM1, GSTT1

GO Terms for genes affiliated with Lung Cancer Susceptibility

Sources:
16Gene Ontology
See all sources

Cellular components related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.7CHRNA5, CHRNA3

Biological processes related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:00680511.1GSTT1, GSTM1, CYP2E1, CYP1A1
2response to drugGO:04249311.0GSTT1, CYP2E1, CYP1A1, OGG1
3response to organic cyclic compoundGO:01407010.9GSTT1, CYP1A1, EPHX1
4behavioral response to nicotineGO:03509510.6CHRNA3, CHRNA5
5nucleotide-excision repairGO:00628910.6ERCC2, OGG1, RPA4

Molecular functions related to Lung Cancer Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:01989911.0EGFR, CYP1A1, CYP2E1, GSTM1
2acetylcholine-activated cation-selective channel activityGO:00488910.7CHRNA3, CHRNA5
3ligand-gated ion channel activityGO:01527610.6CHRNA5, CHRNA3
4acetylcholine receptor activityGO:01546410.4CHRNA3, CHRNA5

Products for genes affiliated with Lung Cancer Susceptibility

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lung Cancer Susceptibility

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet