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MCID: LNG033

Lung Carcinoma malady
4 symptoms, 4 drugs, 808 genes, 28 tissues, 1849 related diseases, 29 phenotypes, 1183 articles, clinical trials, genetic tests.

Summaries for Lung Carcinoma

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6Disease Ontology, 23MedlinePlus, 2CDC, 44Wikipedia, 33OMIM, 22MalaCards
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MedlinePlus: Lung cancer is one of the most common cancers in the world. it is a leading cause of cancer death in men and women in the united states. cigarette smoking causes most lung cancers. the more cigarettes you smoke per day and the earlier you started smoking, the greater your risk of lung cancer. high levels of pollution, radiation and asbestos exposure may also increase risk. common symptoms of lung cancer include a cough that doesn't go away and gets worse over time constant chest pain coughing up blood shortness of breath, wheezing, or hoarseness repeated problems with pneumonia or bronchitis swelling of the neck and face loss of appetite or weight loss fatigue there are many types of lung cancer. each type of lung cancer grows and spreads in different ways and is treated differently. treatment also depends on the stage, or how advanced it is. treatment may include chemotherapy, radiation and surgery. nih: national cancer institute23

MalaCards: Lung Carcinoma, also known as lung cancer, is related to carcinoma and prostatitis, and has symptoms including cough, chest discomfort or pain and weight loss. An important gene associated with Lung Carcinoma is MYCL1 (v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)), and among its related pathways are Rho Family GTPases and Estrogen Pathway. The drugs carmustine and diethylstilbestrol diphosphate and the compounds calcium and paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include the lungs, bone marrow and whole blood, and related mouse phenotypes are homeostasis/metabolism and cellular.

Disease Ontology: A lung cancer that is located in the lungs and has symptom cough and has symptom chest discomfort or pain and has symptom weight loss and has symptom hemoptysis.6

CDC: More people die from lung cancer than any other type of cancer. In the United States in 2008,* 208,493 people were diagnosed with lung cancer, and 158,592 people died from it.† CDC has a number of programs for preventing and controlling lung cancer.2

Wikipedia: Lung cancer is a disease characterized by uncontrolled cell growth in tissues of the lung. If left...44 more...

OMIM: 211980

Aliases & Descriptions for Lung Carcinoma

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2CDC, 43UMLS, 7diseasecard, 8DISEASES, 33OMIM, 23MedlinePlus, 6Disease Ontology, 32Novoseek , 16GeneTests, 40SNOMED-CT, 27NCIt
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Aliases & Descriptions:

lung carcinoma 6 32
lung cancer 7 8 33 23
carcinoma of lung 6 16 43
cancer of lung 6 16
malignant neoplasm of lung 43
malignant neoplasms 43
cancer lung 32
carcinoma 43

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Related Diseases for Lung Carcinoma

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13GeneCards, 14GeneDecks
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Diseases related to lung carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1846)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma146.9PIGR, PIK3CA, PIK3C2A, PIK3CG, LRP1, KLF4
2prostatitis112.0PIK3CA, PIK3C2A, PIK3CG, LRP1, KLF4, NCAM1
3adenocarcinoma103.6PIGR, PIK3CA, PIK3C2A, PIK3CG, LRP1, KLF4
4pancreatitis101.5PIK3CA, PIK3C2A, PIK3CG, LRP1, KLF4, NCAM1
5hepatocellular carcinoma100.3PIGR, PIK3CA, PIK3CG, NCAM1, RELA, RET
6leukemia97.6PIK3CA, PIK3C2A, PIK3CG, LRP1, KLF4, NCAM1
7colorectal cancer97.0PIGR, PIK3CA, PIK3CG, KLF4, NCAM1, NCK1
8neuronitis94.3PIK3CA, PIK3C2A, PIK3CG, LRP1, KLF4, NCAM1
9melanoma92.8PIK3CA, PIK3C2A, PIK3CG, LRP1, NCAM1, NCK1
10gastric cancer90.4PIK3CA, PIK3CG, KLF4, RELA, KIT, VWF
11thyroiditis90.0PIK3CA, PIK3C2A, PIK3CG, LRP1, KLF4, NCAM1
12ovarian carcinoma89.5PIK3CA, PIK3CG, RELA, KIT, RCVRN, PCNA
13colon cancer88.0PIK3CA, PIK3CG, KLF4, NCAM1, PDE4A, RELA
14esophagitis84.8PIK3CA, PIK3C2A, PIK3CG, KLF4, NCAM1, PDE4A
15breast carcinoma84.8PIK3CA, PIK3CG, LRP1, KIT, KITLG, VWF
16cervicitis82.8PIK3CA, PIK3CG, PDE4A, RELA, RET, KIT
17sarcoma80.6PIK3CA, PIK3C2A, PIK3CG, NCAM1, PDE4A, RELA
18colon carcinoma79.4PIGR, PIK3CA, PIK3CG, KLF4, NCAM1, KIT
19neuroblastoma78.2PIK3CA, PIK3CG, LRP1, KLF4, NCAM1, PDE4A
20oral squamous cell carcinoma76.9PIK3CA, PIK3C2A, PCNA, RB1, RBL2, SELE
21hypoxia76.7PIK3CA, PIK3C2A, PIK3CG, LRP1, PDE4A, RELA
22adenoma75.2PIK3CA, KLF4, NCAM1, PDE4A, RET, KIT
23endometrial carcinoma73.4PIK3CA, PIK3C2A, PIK3CG, LRP1, RELA, KIT
24cervical carcinoma72.4PIK3CA, PIK3CG, RELA, KIT, KITLG, PCNA
25cervical cancer71.6PIK3CA, PIK3CG, RELA, PCNA, RB1, RBL2
26nasopharyngitis70.7PIGR, PIK3CA, PIK3CG, RELA, KIT, KITLG
27laryngitis68.9PIK3CA, RELA, PCNA, RB1, RBP1, SETD2
28hepatitis b68.6PIK3CA, PIK3C2A, PIK3CG, NCK1, RELA, KIR3DL2
29renal cell carcinoma67.4PIK3CA, RELA, RET, KIT, PCNA, SELP
30non-small cell lung carcinoma67.3NCAM1, SFTPB, SFTPC, SFTPD, RCVRN, PCNA
31myeloid leukemia66.7PIK3CA, PIK3C2A, PIK3CG, NCAM1, RELA, KIT
32astrocytoma66.4PIK3CA, PIK3CG, LRP1, NCAM1, RELA, RET
33esophageal squamous cell carcinoma66.2PIK3CA, NCAM1, RELA, KIT, PCNA, RB1
34pancreatic carcinoma66.2PIK3CA, NCAM1, RET, KITLG, PCNA, RB1
35fibrosis65.8PIK3CA, PIK3CG, LRP1, PDE4A, RELA, KIT
36retinoblastoma64.6PIK3CA, PIK3CG, NCAM1, KIT, KITLG, RCVRN
37osteosarcoma64.1PIK3CA, PIK3CG, PDE4A, RELA, KIT, VWF
38cholangiocarcinoma63.8PIK3CA, PIK3CG, NCAM1, KIT, PCNA, RB1
39retinitis62.0PIK3CA, PIK3C2A, PIK3CG, LRP1, PDE4A, KIT
40myeloma61.6PIK3CA, PIK3CG, LRP1, NCAM1, PDE4A, RELA
41alzheimer's disease60.5PIK3CA, PIK3CG, LRP1, NCAM1, NCK1, PDE4A
42epithelial ovarian cancer60.2PIK3CA, PIK3CG, RELA, RB1, SERPINB5, SERPINB2
43bladder carcinoma60.1PIGR, PIK3CA, PIK3CG, PCNA, RB1, RBL2
44endometrial cancer59.9PIK3CA, PIK3CG, RET, KITLG, PCNA, RB1
45rheumatoid arthritis59.7PIK3CG, LRP1, PDE4A, RELA, KIT, KITLG
46lymphocytic leukemia59.2PIK3CA, PIK3CG, NCAM1, PDE4A, RELA, KIT
47atherosclerosis58.9PIK3C2A, PIK3CG, LRP1, KLF4, PDE4A, VWF
48peritonitis58.9PIK3C2A, LRP1, RELA, RET, KIT, KITLG
49lymphoblastic leukemia58.8PIK3CA, PIK3CG, NCAM1, RELA, KIT, KITLG
50lung adenocarcinoma58.7PIK3CA, PIK3CG, SFTPB, SFTPC, SFTPD, RCVRN

Graphical network of the top 20 diseases related to lung carcinoma:



Graphical network of diseases related to lung carcinoma

Clinical Features for Lung Carcinoma

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33OMIM, 6Disease Ontology
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Clinical features from OMIM: 211980
Symptoms: cough, chest discomfort or pain, weight loss, hemoptysis.6

Drugs & Therapeutics for Lung Carcinoma

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for lung carcinoma

Drug clinical trials:

Search ClinicalTrials for lung carcinoma

Search NIH Clinical Center for lung carcinoma

Search CenterWatch for lung carcinoma

Inferred drug relations via UMLS/NDF-RT:

43 28 carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, nilutamide

Genetic Tests for Lung Carcinoma

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Anatomical Context for Lung Carcinoma

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11FMA, 22MalaCards
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MalaCards organs/tissues related to lung carcinoma:

22
Bone marrow, Whole blood, Lymph node, Brain, Small intestine, Colon, Kidney, Liver, Lung, Thyroid, Salivary gland, Breast, Skin, Ovary, Testis, Myeloid, Nk cells, T cells, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Bronchial epithelium, Fetal thyroid, Pituitary, Testis germ

FMA organs/tissues related to lung carcinoma:

11
The lungs

Phenotypes for genes affiliated with Lung Carcinoma

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25MGI
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MGI Mouse Phenotypes related to lung carcinoma:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1homeostasis/metabolism phenotypeMP:000537643.1PIGR, PIK3CA, PIK3C2A, PIK3CG, LRP1, KLF4
2cellular phenotypeMP:000538441.9PIK3CA, PIK3CG, KLF4, NCAM1, NCK1, RELA
3mortality/agingMP:001076837.3PIK3CA, PIK3C2A, LRP1, KLF4, NCAM1, NCK1
4growth/size phenotypeMP:000537837.2PIK3CA, PIK3C2A, PIK3CG, LRP1, NCK1, RELA
5cardiovascular system phenotypeMP:000538535.6PIK3CA, PIK3CG, LRP1, PDE4A, RELA, RET
6nervous system phenotypeMP:000363130.7LRP1, NCK1, PDE4A, RELA, REST, KIT
7behavior/neurological phenotypeMP:000538630.2PIK3CA, LRP1, KLF4, NCAM1, NCK1, KIT
8tumorigenesisMP:000200630.2PIK3CA, KLF4, RET, KIT, KITLG, SFTPC
9immune system phenotypeMP:000538727.8PIGR, LRP1, PDE4A, KIT, VWF, RBP1
10muscle phenotypeMP:000536927.7PIK3CA, PIK3CG, LRP1, RELA, RET, KIT
11integument phenotypeMP:001077126.5PIK3CG, KLF4, RELA, KIT, KITLG, RB1
12digestive/alimentary phenotypeMP:000538126.2PIGR, KLF4, RET, KIT, KITLG, VWF
13hematopoietic system phenotypeMP:000539726.1PIGR, KIT, PCNA, RBP1, RBL1, SERPINB9
14normal phenotypeMP:000287325.7LRP1, KLF4, NCK1, RELA, RET, VRK1
15vision/eye phenotypeMP:000539125.2PIK3CA, NCAM1, RELA, REST, KIT, KITLG
16skeleton phenotypeMP:000539024.9PIK3CG, LRP1, RELA, KIT, KITLG, RB1
17reproductive system phenotypeMP:000538924.6PIGR, PIK3CA, KLF4, RET, VRK1, SFTPC
18embryogenesis phenotypeMP:000538023.0PIK3CA, NCK1, REST, RET, KIT, RBL2
19renal/urinary system phenotypeMP:000536721.2NCK1, RET, KIT, SELP, BRAF, VHL
20no phenotypic analysisMP:000301219.1REST, RET, SFTPC, PCNA, RB1, RBL2
21limbs/digits/tail phenotypeMP:000537118.9RELA, RET, KIT, KITLG, RB1, RBL2
22adipose tissue phenotypeMP:000537518.2PIK3CA, PIK3C2A, LRP1, RB1, RBL1, SERPINE1
23hearing/vestibular/ear phenotypeMP:000537717.1KIT, KITLG, RB1, RBP1, MYC, BMP2
24craniofacial phenotypeMP:000538217.0KLF4, KIT, KITLG, RBL1, LPAR1, MYCN
25liver/biliary system phenotypeMP:000537015.8KIT, RBP1, RBL1, VHL, VEGFA, MYCN
26pigmentation phenotypeMP:000118615.2KIT, KITLG, RB1, RBP1, BRAF, MYC
27endocrine/exocrine gland phenotypeMP:000537914.5KLF4, RET, RBL2, RBL1, PAX7, CHRM3
28other phenotypeMP:000539514.3RARA, RARB, PBX1, KDR, LAMA5, LAMC2
29respiratory system phenotypeMP:000538813.2RET, SFTPC, SFTPD, SELP, LPAR2, MYCN

Publications for genes affiliated with Lung Carcinoma

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35PubMed
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Articles related to lung carcinoma:

(show top 50)    (show all 1183)
idTitleAuthorsYearAffiliating Genes
1Cyclooxygenase-2 gene and lung carcinoma risk. (20645029)Coskunpinar E.... Agachan B.2010PTGS2, MT-CO2
2Baicalin suppresses lung carcinoma and lung metastasi s by SOD mimic and HIF-1alpha inhibition. (20036231)Du G.... Liang W.2010SOD1, HIF1A, CAT
3Overexpression of hedgehog pathway molecules and FOXM 1 in non-small cell lung carcinomas. (19200615)Gialmanidis I.P.... Papadaki H.2009GLI1, PTCH1, FOXM1
4Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth fa ctor receptor. (19509246)Freeman D.J.... Radinsky R.2009EGFR, EGF
5Cytoplasmic and nuclear maspin expression in lung carcinomas: an immunohistochemical study using tissue microarrays. (18665036)Zheng H.C.... Takano Y.2008CASP3, BSG, SERPINB5
6Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma. (18579664)Niikawa H.... Sasano H.2008CYP19A1
7Status of gene mutation and copy number of EGFR in 290 cases of non-small cell lung carcinoma (19094482)Liang Z.Y.... Liu T.H.2008EGFR
8Pirh2 shRNA mediated by psiRNA-hH1 vector plasmid effectively inhibits the proliferation of lung carcinoma cells: in vitro and in vivo experiments (17686242)Su Y.... Zhou Q.2007RCHY1
9Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis. (17485391)Oyama T.... Kawamoto T.2007CYP2A6, CYP2E1, AHR
10Enhancement of cell death by TNF alpha-related apoptosis-inducing ligand (TRAIL) in human lung carcinoma A549 cells exposed to x rays under hypoxia. (17895594)Takahashi M.... Kuwabara M.2007TNF, TNFSF10
11Synergistic inhibition of growth of lung carcinomas by antagonists of growth hormone-releasing hormone in combination with docetaxel. (16983095)Hohla F.... Kanashiro C.A.2006HRAS, PTGS2
12Tyroservatide therapy for tumor growth, invasion and metastasis of Lewis lung carcinoma and human lung carcinoma A549. (17245103)Zheng M.... Yao Z.2006ICAM1
13Alternative splicing of MDM2 mRNA in lung carcinomas and lung cell lines. (15714438)Weng M.W.... Ko J.L.2005MDM2
14DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas. (14661059)Yuan B.Z.... Reynolds S.H.2004DLC1
15Mutant alpha-actinin-4 promotes tumorigenicity and regulates cell motility of a human lung carcinoma. (15048094)Menez J.... Mami-Chouaib F.2004ACTN4
16Sodium 4-phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway. (15389886)Zhang X.... Yu Q.2004MAPK1, MAPK8
17MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinoma. (15331175)Liu G.... Christiani D.C.2004SOD2, MPO
18S100A2 is strongly expressed in airway basal cells, preneoplastic bronchial lesions and primary non-small cell lung carcinomas. (15467767)Smith S.L.... Heighway J.2004S100A2
19Pathogenetic and biologic significance of TP14ARF alterations in nonsmall cell lung carcinoma. (12581892)Park M.J.... Yokota J.2003CDKN2A
20GST M1 and CYP1A1 gene polymorphism and daily fruit consumption in Turkish patients with non-small cell lung carcinomas. (14758730)Ozturk O.... Gurses A.2003CYP1A1, GSTM1
21The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies. (12579323)Varker K.A.... Williams C.L.2003RHOA
22Expression and immunogenicity of a tumor-associated antigen, 90K/Mac-2 binding protein, in lung carcinoma. (12404290)Ozaki Y.... Ohkubo I.2002LGALS3BP
23Prognostic factors and c-erbB-2 expression in non-small-cell lung carcinoma (c-erbB-2 in non-small cell lung carcinoma). (11847606)Bakir K.... Elbeyli L.2002ERBB2
24Parathyroid hormone-related protein measured at the time of first visit is an indicator of bone metastases and survival in lung carcinoma patients with hypercalcemia. (12365018)Hiraki A.... Harada M.2002PTHLH
25Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma. (12412174)Kawakami T.... Nakamura M.2002VEGFA, NRP1, NRP2
26A point mutation in the alpha-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma. (11358829)Echchakir H.... Coulie P.G.2001ACTN4
27Polymorphisms of the CYP1A1 and GSTM1 genes in relation to individual susceptibility to lung carcinoma in Chinese population. (11406420)Chen S.... Wu J.2001CYP1A1, GSTM1
28Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells. (11678615)Chuang S.M.... Yang J.L.2001MAPK1, MAPK8
29Simvastatin effects on a human lung carcinoma and cho lesterol homeostasis of host and non-host mice. (11935385)Polo M.... de Bravo M.G.2001HMGCR
30Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas. (11389090)Toyooka K.O.... Gazdar A.F.2001CDH13
31Video-assisted minithoracotomy versus conventional p osterolateral thoracotomy for performing lobectomy of lung carcinomas (10639787)Inaoka M.... Kawaharada N.2000PIK3C2A
32Enhanced expression of Tie2, its ligand angiopoietin-1, vascular endothelial growth factor, and CD31 in human non-small cell lung carcinomas. (10499626)Takahama M.... Konishi Y.1999FLT4, FLT1, TEK
33Detection of cytoskeletal proteins in small cell lung carcinoma. (10707834)Hlozankova M.... Viklicky V.1999TUBB3
34Quantitation by competitive PCR assay of vascular endothelial growth factor in non-small cell lung carcinomas. (9863024)Boldrini L.... Fontanini G.1999VEGFA
35Expression of CD44 variant exon 6 in stage I non-small cell lung carcinoma as a prognostic factor. (9515789)Hirata T.... Wada H.1998CD44
36Smoking-related increase of O6-methylguanine-DNA methyltransferase expression in human lung carcinomas. (9683184)Mattern J.... Volm M.1998MGMT
37Prognostic value of basic fibroblast growth factor and its receptor (FGFR-1) in patients with non-small cell lung carcinomas. (9274456)Volm M.... Stammler G.1997FGFR1, FGF2
38Induction of apoptosis in human non-small cell lung carcinoma cells by the novel synthetic retinoid CD437. (9365537)Sun S.Y.... Lotan R.1997JUN
39Functional inactivation of p53 by antisense RNA induces invasive ability of lung carcinoma cells and downregulates cytokeratin synthesis. (8712687)Mukhopadhyay T.... Roth J.A.1996TP53
40NADPH-oxidase and a hydrogen peroxide-sensitive K+ channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines. (8917565)Wang D.... Cutz E.1996CYBB, CYBA, KCNC3
41p21 RNA and protein expression in non-small cell lung carcinomas: evidence of p53-independent expression and association with tumoral differentiation. (8649834)Marchetti A.... Bevilacqua G.1996TP53, CDKN1A
42Apoptosis occurs independently of bcl-2 and p53 over-expression in non-small cell lung carcinoma. (8818693)O'Neill A.J.... Gaffney E.F.1996TP53, BCL2
43A human small cell lung carcinoma cell line, resistant to 4'-(9-acridinylamino)-methanesulfon-m-anisidide and cross-resistant to camptothecin with a high level of topoisomerase I. (8093110)Prost S.... Riou G.1994TOP1
44The effect of thrombospondin on invasion of fibrin gels by human A549 lung carcinoma. (8305744)Hosokawa T.... Tuszynski G.P.1993THBS1, ADAMTSL1
45P-glycoprotein associated expression of c-fos and c-jun products in human lung carcinomas. (8100127)Volm M.1993MYC, FOS, JUN
46Clinical correlates of MDR1 (P-glycoprotein) gene expression in ovarian and small-cell lung carcinomas. (1359152)Holzmayer T.A.... Roninson I.B.1992ABCB1
47Tumor necrosis factor stimulates urokinase-type plasminogen activator and inhibitor type 1 production in A549 lung carcinoma cells: treatment of monolayer and tridimensional cultures. (1796296)Dosne A.M.... Samama M.1991PLAU
48Histocompatibility locus antigens (HLA) in the epidermoid type of lung carcinoma. (2229145)PrazA!k J.... ChytrA1 J.1990HLA-B
49Effect of recombinant interleukin-1 alpha, recombinant interleukin-2, recombinant interferon-beta, and recombinant tumor necrosis factor on subcutaneously implanted adenocarcinoma 755 and Lewis lung carcinoma. (2395006)Iigo M.... Hoshi A.1990IL2, IL1A
50Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. (6308465)Shimizu K.... Wigler M.1983KRAS

Expression for genes affiliated with Lung Carcinoma

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Lung Carcinoma

Pathways for genes affiliated with Lung Carcinoma

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36QIAGEN, 3Cell Signaling Technology, 20KEGG, 37R&D Systems, 41Thomson Reuters, 10EMD Millipore, 34PharmGKB
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Pathways related to lung carcinoma according to GeneDecks:

(show top 50)    (show all 332)
idPathwayScoreTop Affiliating Genes
1Rho Family GTPases3619.3KIT, KITLG, SEMA5A, VIM, VEGFC, BMP2
2Estrogen Pathway3617.8KIT, KITLG, SEMA5A, BRAF, VEGFC, BMP2
3JAK-STAT Pathway3616.9KIT, KITLG, SEMA5A, VEGFC, MYC, BMP2
4Paxillin Interactions3616.8NCK1, KIT, KITLG, SEMA5A, VEGFC, VCL
5Phospholipase-C Pathway3616.4KIT, KITLG, SEMA5A, VEGFC, BMP2, BMP4
6Nanog in Mammalian ESC Pluripotency3616.3KIT, KITLG, SEMA5A, BRAF, VEGFC, BMP2
7STAT3 Pathway3615.3BRAF, MYC, BMP2, BMP4, BMP6, BMPR2
8Cell Cycle / Checkpoint Control315.3VRK1, RCHY1, PCNA, RB1, VCP, USP4
914-3-3 Induced Intracellular Signaling3615.3KITLG, SEMA5A, VEGFC, BMP2, BMP4, RAF1
10Small cell lung cancer2015.2PIK3CA, PIK3CG, RELA, RB1, MYC, RARB
11Activation of PKC through GPCR3615.0KIT, KITLG, SEMA5A, VEGFC, BMP2, BMP4
12Apoptotic Pathways in Synovial Fibroblasts3614.6KIT, KITLG, SEMA5A, VEGFC, BMP2, BMP4
13Telomerase Components in Cell Signaling3614.6KIT, KITLG, RB1, SEMA5A, VEGFC, MYC
14PEDF Induced Signaling3614.6RELA, BRAF, BMP2, BMP4, BMP6, RAF1
15Toxoplasmosis2014.5PIK3CA, PIK3CG, RELA, BIRC2, BIRC3, BCL2
16Apoptosis Signaling Pathways3714.3BID, BIRC2, BIRC3, BIRC5, BIRC7, BCL2
17UPA-UPAR Pathway3614.3SERPINE1, LAMA5, LAMB1, LAMB3, LAMC2, JUN
18IP3 Pathway3614.2KITLG, SEMA5A, VEGFC, BMP2, BMP4, BMP6
19PPAR Pathway3613.8KIT, KITLG, SEMA5A, VEGFC, BMP2, BMP4
20Development_VEGF signaling via VEGFR2 - generic cascades4113.7PIK3CA, NCK1, RELA, VEGFA, VCL, RAF1
21Amoebiasis2013.6PIK3CA, RELA, SERPINB9, SERPINB2, VCL, MUC2
22TGF-beta Signaling Pathways3713.6PIK3CG, RELA, BRAF, MYC, RAF1, RAC1
23FAK1 Signaling3613.5BRAF, VCL, RAF1, RAC1, BCAR1, LAMA5
24Non-small cell lung cancer2013.4PIK3CA, PIK3CG, RB1, BRAF, RASSF5, RAF1
25Apoptosis and survival TNFR1 signaling pathway1013.0RELA, BID, BIRC2, BIRC3, BAX, XIAP
26Apoptosis and survival_Role of CDK5 in neuronal death and survival4113.0PIK3CA, RAF1, BCL2, BAX, JUN, CDK1
27Hepatitis C2013.0PIK3CA, PIK3CG, RELA, BRAF, RAF1, CLDN7
28Development Thrombopoietin-regulated cell processes1013.0PIK3CA, BRAF, MYC, RAF1, RAC1, BIRC5
29TRKA Signaling3613.0BRAF, MYC, RAF1, RAP1B, RAC1, BAX
30Calpain Protease Regulates Cellular Mechanics3613.0RB1, VCL, CDK2, CDKN1B, CDK4, ITGA4
31UVA-Induced MAPK Signaling3612.9BCL2L1, JUN, FOS, MAPK8, MAPK14, MAPK1
32Apoptosis and survival FAS signaling cascades1012.9BID, BIRC2, PARP1, BCL2, BAX, XIAP
33Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR24112.8RELA, MYC, RAF1, BCL2, BAX, JUN
34Acute myeloid leukemia2012.7PIK3CA, PIK3CG, KIT, BRAF, MYC, RARA
35Chagas disease (American trypanosomiasis)2012.7PIK3CA, PIK3CG, RELA, SERPINE1, CFLAR, JUN
36Development VEGF-family signaling1012.6PIK3CA, VEGFC, RAF1, KDR, ITGAV, ITGB1
3714-3-3 Induced Apoptosis3612.6BID, BCL2, JUN, FOS, IRAK1, IL1A
38Development_IGF-1 receptor signaling4112.4PIK3CA, RELA, MYC, RAF1, BCL2L1, MTOR
39Apoptosis and survival_Lymphotoxin-beta receptor signaling4112.2RELA, BIRC2, BAX, JUN, IL2, IL8
40Pathway_PA1659800503412.2BRAF, MYC, RAF1, KDR, JUN, FLT1
41Immune response_MIF in innate immunity response4112.1RELA, LBP, JUN, IRAK1, MIF, IL1B
42Development_VEGF signaling and activation4112.0PIK3CA, RELA, SELE, VEGFA, RAF1, RASA1
43Sorafenib Pharmacodynamics3412.0PIK3CA, PIK3C2A, RET, BRAF, RAF1, KDR
44TNF-Induced Apoptosis Implicating Sphingolipids3612.0RAF1, BAX, MAPK8, MAP2K2, MAPK3, MAPK14
45Apoptosis and survival Role of CDK5 in neuronal death and survival1011.7BCL2, APAF1, CASP9, ERBB3, CYCS
46PI3K Signaling in B-Lymphocyte3611.6PIK3C2A, RAF1, RAC1, JUN, FOS, MAPK8
47Immune response_IL-1 signaling pathway4111.5RELA, SERPINE1, UBC, JUN, FOS, IRAK1
48EGFR Inhibitor Pathway, Pharmacodynamics3411.4CAMK2B, CAMK2D, HRAS, NRAS, KRAS, STAT5B
49ErbB2-ErbB3 Heterodimers3611.4RAF1, GSK3B, MAP2K2, MAP2K1, ERBB3, ERBB2
50RAR-Gamma-RXR-Alpha Degradation3611.0BMP2, BMP4, UBC, IL11, IL15, IL2

Compounds for genes affiliated with Lung Carcinoma

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Sources:
32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
See all sources

Compounds related to lung carcinoma according to GeneDecks:

(show top 50)    (show all 470)
idCompoundScoreTop Affiliating Genes
1calcium32 9 18 9 36.3PIGR, PIK3C2A, LRP1, PDE4A, RELA, REST
2paclitaxel32 34 9 9 31.6PIK3CA, PIK3CG, KIT, KITLG, PCNA, RB1
3progesterone32 42 9 18 9 31.2PIK3CA, NCAM1, PDE4A, KIT, SFTPB, PCNA
4atp32 25.0PIK3CA, PIK3C2A, NCAM1, PDE4A, RET, KIT
5glucose32 20.4PDE4A, KIT, SETD2, BRAF, BRS3, VHL
6resveratrol32 9 18 9 22.9PIK3CA, PIK3CG, PCNA, RB1, BSG, VEGFA
7forskolin32 42 9 9 22.6PDE4A, VIM, VIP, BRAF, BMP2, BMP4
8imatinib32 34 9 9 21.6PIK3CA, PIK3CG, RET, KIT, KITLG, VIP
9cholesterol32 9 18 9 21.3PIK3CA, PIK3C2A, LRP1, KITLG, VWF, SFTPB
10bromodeoxyuridine32 17.8PIK3CA, NCAM1, KITLG, PCNA, RB1, VIM
11tgf beta132 17.0LRP1, KITLG, RBL2, RBL1, SETD2, SERPINE1
12cytarabine32 34 9 9 19.6KIT, KITLG, PCNA, RB1, VIM, MYC
13pdtc32 16.6PIK3CA, PIK3CG, SFTPB, SELE, SETD2, SERPINB5
14ascorbic acid32 18 17.5PIK3CG, SFTPB, PCNA, SETD2, SERPINB2, BMP2
15herbimycin a32 42 17.4PIK3CG, RET, KITLG, SELE, MYC, BMP6
16gf 109203x32 42 17.3PIK3CG, KITLG, VEGFA, VCL, RAF1, CHRM3
17agarose32 15.8KIT, KITLG, VWF, SFTPD, MYC, MYCN
18gtp32 15.8PIK3CA, PIK3C2A, VIP, BRAF, RAF1, RAP1B
19polyacrylamide32 15.4SFTPB, RB1, BMP2, RARA, LGALS1, LGALS3
20trastuzumab32 34 9 9 18.3PIK3CA, PIK3CG, KIT, VEGFC, RAF1, BIRC5
21sulforaphane32 14.8PIK3CG, RB1, PARP1, KEAP1, JUN, CDKN1A
22histidine32 14.8PDE4A, KITLG, VHL, RARA, LGALS1, CHGA
23hydroxyurea32 9 9 16.5KIT, KITLG, PCNA, MYC, MYCN, RAD9A
24dutp32 14.5PCNA, BIRC5, PARP1, BCL2, BCL2L1, LGALS3
25topotecan32 9 9 16.2SETD2, BIRC5, PARP1, BCL2, BCL2L1, MUC16
26ornithine32 18 15.0KLF4, SERPINB2, MYC, MYCN, RARA, MTAP
27potassium32 9 18 9 17.0PIK3CA, PIK3C2A, NCAM1, PDE4A, KITLG, RCVRN
28azathioprine32 34 9 9 16.8PCNA, VIM, BMP2, BMP4, RARB, RASSF1
2917-(allylamino)-17-demethoxygeldanamycin32 13.8KIT, SETD2, BRAF, RAF1, BIRC5, CDKN1A
30egcg32 13.5PIK3CG, RAF1, BCL2L1, XIAP, CDK2, IVL
31vitamin e succinate32 13.5MYC, BMP6, PARP1, BCL2, BCL2L1, BAX
32norepinephrine32 9 18 9 16.4PIK3C2A, PDE4A, KITLG, VWF, SELE, SELP
33biotin32 9 18 9 16.3KLF4, KITLG, VWF, PCNA, RB1, VIM
34b 72332 13.3PCNA, VIM, CHKA, CHGA, MUC1, MUC16
35dbc-amp32 12.9LRP1, NCAM1, PDE4A, VIM, VIP, MYCN
36staurosporin32 12.9PIK3CA, PIK3CG, BCL2, BCL2L1, JUN, CDKN3
37tunicamycin32 12.8PIK3CG, MUC2, XBP1, CD44, GRIN1, GRP
38phenobarbital32 9 9 14.8PCNA, MYC, CHRNA4, FOXM1, GSTM1, GRIN1
39z-vad-fmk32 42 13.7PARP1, BCL2, BCL2L1, BAX, GZMB, MAPK14
40cetuximab32 34 9 9 15.7BRAF, KDR, CDKN1B, CDKN3, IGF1R, ERBB3
41radicicol32 42 9 9 15.6PIK3CG, VEGFA, RAF1, JUN, GSN, MAPK3
42mannitol32 9 9 14.4SELP, CGA, CDKN3, CDH1, IVL, FGF2
43ifosfamide32 9 9 14.4CGA, CGB, CGB5, MGMT, GSTM1, GSTP1
44ionomycin32 12.3SETD2, CDK4, CD40, FOS, GSN, GRP
45bisindolylmaleimide32 12.2RAF1, RAC1, CFLAR, FOS, GRP, MAPK3
46n-ethylmaleimide32 9 9 14.0VWF, VCP, MYC, FUT6, CDC25C, CDKN3
47simvastatin32 34 42 9 18 9 16.9PIK3C2A, KITLG, VWF, SELE, SELP, SERPINE1
48ibuprofen32 9 18 9 14.6BMP6, CGB5, MMP1, MMP2, MMP3, IL10
49pravastatin32 34 9 18 9 15.0PIK3C2A, SELE, SELP, SERPINE1, BMP2, RAC1
50losartan32 34 9 9 13.9VWF, PCNA, SELE, SELP, SERPINE1, BMP6

GO Terms for genes affiliated with Lung Carcinoma

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Sources:
12Gene Ontology
See all sources

Cellular components related to lung carcinoma according to GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573735.3PIK3C2A, PIK3CG, LRP1, NCK1, RELA, REST
2nucleusGO:00563435.2PIK3C2A, LRP1, NCK1, PDE4A, RELA, REST
3cytosolGO:00582929.7PIK3CA, PIK3C2A, PIK3CG, NCK1, PDE4A, RELA
4plasma membraneGO:00588624.7PIK3C2A, PIK3CG, NCAM1, NCK1, KIT, KIR3DL2
5extracellular regionGO:00557620.9PIGR, NCAM1, KITLG, VWF, SFTPA1, SFTPD
6extracellular spaceGO:00561518.6KIT, KITLG, SFTPA1, SFTPB, SFTPC, SFTPD
7integral to plasma membraneGO:00588718.2PIGR, LRP1, RET, KIR3DL2, SELP, LPAR1
8nucleoplasmGO:00565418.0RELA, PCNA, RB1, RBL2, RBL1, VHL
9cell surfaceGO:00998615.6NCAM1, VEGFA, LPAR1, LPAR2, BMP2, BMPR2
10perinuclear region of cytoplasmGO:04847115.1PDE4A, SELE, NANOS1, LAMB1, LAMC2, XRCC3
11membrane raftGO:04512112.2SELE, BSG, CD24, CD36, CD55, ITGB1
12external side of plasma membraneGO:00989712.1NCAM1, KIT, VWF, SELP, KDR, CHRNA4
13caveolaGO:00590111.8SELE, BMPR2, SCARB1, CDH13, FASLG, MAPK3
14platelet alpha granule lumenGO:03109311.4VWF, SERPINE1, VEGFA, VEGFC, FN1, FIGF

Biological processes related to lung carcinoma according to GeneDecks:

(show top 50)    (show all 70)
idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716520.5PDE4A, RET, KIT, KITLG, RCVRN, VEGFC
2apoptotic processGO:00691518.9VIM, RASSF5, RAF1, RAC1, BID, BIRC2
3positive regulation of cell proliferationGO:00828418.2KIT, VIP, VEGFA, VEGFC, MYC, RARA
4negative regulation of apoptotic processGO:04306618.0PIK3CG, RELA, SERPINE1, BRAF, VEGFA, MYC
5negative regulation of cell proliferationGO:00828517.9KLF4, REST, BTG3, VHL, BMP2, BMP4
6response to drugGO:04249317.2PDE4A, VEGFC, MYC, BCHE, BCL2, LGALS1
7positive regulation of transcription, DNA-dependentGO:04589317.1KLF4, RELA, REST, RET, RB1, VHL
8positive regulation of transcription from RNA polymerase II promoterGO:04594416.1KLF4, NCK1, RELA, RB1, RBL1, SERPINE1
9cell proliferationGO:00828315.7KITLG, PCNA, RAF1, RAP1B, BCAR1, BCL2L1
10blood coagulationGO:00759615.7PIK3CA, PIK3CG, VWF, SELP, SERPINB2, SERPINE1
11negative regulation of transcription from RNA polymerase II promoterGO:00012215.6KLF4, REST, VHL, MYC, BMP2, BMP4
12angiogenesisGO:00152515.5PIK3CA, PIK3CG, SETD2, SERPINE1, VEGFA, VEGFC
13cell adhesionGO:00715515.1NCAM1, KITLG, VWF, SELP, SEMA5A, VCL
14response to hypoxiaGO:00166615.0SFTPB, VEGFA, BMP2, RAF1, USF1, BCL2
15negative regulation of transcription, DNA-dependentGO:04589214.9KLF4, RELA, REST, RB1, BMP2, BMP4
16anti-apoptosisGO:00691614.6PIK3CA, RELA, SERPINB9, SERPINB2, BRAF, VHL
17virus-host interactionGO:01904814.5RELA, RB1, RBL1, VIM, KDR, SCARB1
18axon guidanceGO:00741114.4NCAM1, NCK1, SEMA5A, RAF1, RAC1, LAMB1
19cell-cell signalingGO:00726714.2SEMA5A, BMP2, CGA, CGB, CEACAM6, FGF3
20positive regulation of cell migrationGO:03033514.0RET, VIL1, VEGFA, BMP2, KDR, BCAR1
21innate immune responseGO:04508714.0PIK3CG, RELA, SFTPD, BCL2, BCL2L1, LGALS3
22induction of apoptosis by intracellular signalsGO:00862913.8MYC, BID, BCL2, BCL2L1, BBC3, BAK1
23inflammatory responseGO:00695413.8PIK3CG, RELA, KIT, SELE, SELP, BMP2
24positive regulation of apoptotic processGO:04306513.7REST, LPAR1, BMP2, BMP4, RARB, RAD9A
25activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691913.5VCP, MYC, BBC3, BAX, CDKN1B, CDKN2A
26platelet activationGO:03016813.4PIK3CA, PIK3CG, VWF, SELP, SERPINE1, VEGFA
27response to lipopolysaccharideGO:03249613.3SFTPB, SFTPC, SELE, SELP, LBP, JUN
28positive regulation of endothelial cell proliferationGO:00193813.3VEGFA, BMP2, BMP4, BMP6, BMPR2, KDR
29nerve growth factor receptor signaling pathwayGO:04801112.9PIK3CA, RELA, BRAF, RAF1, RAC1, BCAR1
30positive regulation of protein phosphorylationGO:00193412.9VEGFA, BMP2, BMP4, MTOR, CD40, FLT4
31positive regulation of MAP kinase activityGO:04340612.8PIK3CG, KITLG, VEGFA, CD24, CD40, FLT1
32epidermal growth factor receptor signaling pathwayGO:00717312.7PIK3CA, PIK3C2A, VIL1, RAF1, BCAR1, UBC
33phosphatidylinositol-mediated signalingGO:04801512.6PIK3CA, PIK3C2A, PCNA, MTOR, CDKN1B, GSK3B
34agingGO:00756812.6BAK1, JUN, GSN, IL15, IL1B, FAS
35positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406812.5KIT, SELP, KDR, FLT1, FGFR1, ANGPT1
36response to ethanolGO:04547112.3BCL2, BAK1, CD27, CDK1, MMP9, MGMT
37G1/S transition of mitotic cell cycleGO:00008212.1PCNA, RB1, BCL2, CKS1B, UBC, CDKN1A
38fibroblast growth factor receptor signaling pathwayGO:00854311.8PIK3CA, BRAF, RAF1, UBC, MTOR, CDKN1B
39platelet degranulationGO:00257611.4VWF, SELP, SERPINE1, VEGFA, VEGFC, VCL
40toll-like receptor 3 signaling pathwayGO:03413811.2RELA, UBC, JUN, CDK1, FOS, IRAK1
41TRIF-dependent toll-like receptor signaling pathwayGO:03566611.2RELA, UBC, JUN, CDK1, FOS, IRAK1
42MyD88-independent toll-like receptor signaling pathwayGO:00275611.1RELA, UBC, JUN, CDK1, FOS, IRAK1
43Toll signaling pathwayGO:00806311.1RELA, UBC, LBP, JUN, CDK1, FOS
44activation of MAPKK activityGO:00018611.0BMP4, RAF1, MAP2K2, F2R, NRAS, CRK
45activation of MAPK activityGO:00018711.0KIT, LPAR1, LPAR2, UBC, CDK1, IRAK1
46toll-like receptor 4 signaling pathwayGO:03414211.0RELA, UBC, JUN, CDK1, FOS, IRAK1
47toll-like receptor signaling pathwayGO:00222410.9RELA, UBC, JUN, CDK1, FOS, IRAK1
48MyD88-dependent toll-like receptor signaling pathwayGO:00275510.6RELA, UBC, JUN, CDK1, FOS, IRAK1
49toll-like receptor 1 signaling pathwayGO:03413010.5RELA, UBC, JUN, CDK1, FOS, IRAK1
50toll-like receptor 2 signaling pathwayGO:03413410.5RELA, UBC, JUN, CDK1, FOS, IRAK1

Molecular functions related to lung carcinoma according to GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551548.4NPM1, PSMB9, STK11, STAT5B, STAT3, STMN2
2ATP bindingGO:00552421.0GLUL, ALK, HYOU1, IGF1R, MAP2K1, MAPK9
3protein homodimerization activityGO:04280316.3NR3C1, HSP90AA1, CCL5, ENG, ENO2, IL6R
4identical protein bindingGO:04280215.7NFKBIA, SMAD4, PTPRG, TNF, TP73, TP63
5protein heterodimerization activityGO:04698215.5RXRA, NR3C1, PPP2R4, CYBB, CYBA, TP53
6enzyme bindingGO:01989914.7NFKBIA, RXRA, PLAUR, PPARG, CTNNB1, CYP2E1
7transcription factor bindingGO:00813414.5CTNNB1, SP1, DDIT3, TNFRSF10A, TP73, TP53
8protein kinase bindingGO:01990113.8TP73, TP53, HSPB1, CCNA1, CCND1, CCNA2
9growth factor activityGO:00808313.7GDF5, TYMP, EGF, PDGFA, F2, IGF2
10receptor bindingGO:00510213.0SRC, TNFSF13, TNFSF10, TNC, HLA-B, GJA1
11cytokine activityGO:00512513.0TNFSF10, IL1A, IL17A, IL15, IL11, IL10
12transmembrane receptor protein tyrosine kinase activityGO:00471412.2TEK, DDR1, DDR2, PDGFRA, EGFR, TIE1

Sources for Lung Carcinoma

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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