MCID: LNG017
MIFTS: 46

Lung Giant Cell Carcinoma malady

Cancer diseases, Respiratory diseases categories

Summaries for Lung Giant Cell Carcinoma

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Wikipedia:64 Giant cell carcinoma of the lung (GCCL) is a rare histological form of large-cell lung carcinoma, a... more...

MalaCards based summary: Lung Giant Cell Carcinoma, also known as gip - giant cell interstitial pneumonitis, is related to neuroendocrine carcinoma and hepatitis. An important gene associated with Lung Giant Cell Carcinoma is IL8 (interleukin 8), and among its related pathways are E-cadherin signaling in the nascent adherens junction and Arf6 trafficking events. The compounds chi 2 and methyl selenol have been mentioned in the context of this disorder. Affiliated tissues include large undifferentiated cells and lung, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Disease Ontology:9 A lung carcinoma that is located in large undifferentiated cells.

Aliases & Classifications for Lung Giant Cell Carcinoma

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Lung Giant Cell Carcinoma, Aliases & Descriptions:

Name: Lung Giant Cell Carcinoma 9
Gip - Giant Cell Interstitial Pneumonitis 61
Giant Cell Carcinoma of Lung 61
 
Giant Cell Lung Carcinoma 9
Carcinoma, Giant Cell 61
Giant Cell Carcinoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology9 DOID:5583
MeSH34 D018286
SNOMED-CT56 42596004, 254631008
NCIt39 C3779

Related Diseases for Lung Giant Cell Carcinoma

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Diseases related to Lung Giant Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma30.4KRT18, CDH1
2hepatitis30.1TIMP2, KRT18
3choriocarcinoma29.8TIMP2, TIMP1, MMP2, KRT18
4fibromatosis10.5TIMP2
5pulpitis10.5TIMP1
6actinic keratosis10.4PCNA
7alcoholic hepatitis10.3KRT18, IL8
8arthropathy10.3TIMP1
9bronchopulmonary dysplasia10.3TIMP1, IL8
10arthritis10.3TIMP1, IL8
11monocytic leukemia10.3IL8
12oxyphilic adenoma10.3NME1, KRT18
13keratoacanthoma10.3PCNA, NME1
14leukoplakia10.3NME1, PCNA
15smooth muscle tumor10.3PCNA, NME1
16proliferative vitreoretinopathy10.2TIMP2, TIMP1
17gestational trophoblastic neoplasm10.2NME1, PCNA
18kidney cancer10.2CDH1
19bronchiolo-alveolar adenocarcinoma10.2CDH1, TIMP2
20myelofibrosis10.2TIMP2, TIMP1
21pleomorphic adenoma10.2PCNA, KRT18
22laryngeal benign neoplasm10.2PCNA, NME1
23tongue squamous cell carcinoma10.2CDH1, NME1
24cervical adenocarcinoma10.2NME1, CDKN2A
25acquired immunodeficiency syndrome10.2
26renal fibrosis10.2TIMP1, CDH1
27cervical intraepithelial neoplasia10.2NME1, CDKN2A
28follicular adenoma10.2NME1, CDH1
29cervical squamous cell carcinoma10.2TIMP2, CDKN2A
30idiopathic pulmonary fibrosis10.2KRT18, IL8, TIMP1
31proliferative diabetic retinopathy10.2IL8, TIMP1, TIMP2
32periodontitis10.2TIMP2, TIMP1, IL8
33synovitis10.2TIMP2, TIMP1, IL8
34salivary gland adenoid cystic carcinoma10.2PCNA, CDH1
35nasopharynx carcinoma10.1CDH1, CDKN2A
36gastritis10.1KRT18, PCNA, IL8
37breast ductal carcinoma10.1TIMP2, NME1, CDH1
38papillary carcinoma10.1NME1, KRT18, CDH1
39breast fibroadenoma10.1TIMP2, PCNA, NME1
40liver cirrhosis10.1KRT18, TIMP1, TIMP2
41gastric adenocarcinoma10.1CDH1, NME1, TIMP2
42breast cancer, invasive ductal10.1CDH1, NME1, PCNA
43hypertrophic scars10.1TIMP1, MMP2
44tongue cancer10.1CDH1, MMP2
45galactosemia10.1TIMP1, PCNA, KRT18
46cystadenoma10.1
47follicular dendritic cell sarcoma10.1
48large cell neuroendocrine carcinoma10.1
49gynecomastia10.1
50small cell carcinoma10.1

Graphical network of the top 20 diseases related to Lung Giant Cell Carcinoma:



Diseases related to lung giant cell carcinoma

Symptoms for Lung Giant Cell Carcinoma

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Drugs & Therapeutics for Lung Giant Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Lung Giant Cell Carcinoma

Search NIH Clinical Center for Lung Giant Cell Carcinoma

Genetic Tests for Lung Giant Cell Carcinoma

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Anatomical Context for Lung Giant Cell Carcinoma

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MalaCards organs/tissues related to Lung Giant Cell Carcinoma:

32
Lung

FMA organs/tissues related to Lung Giant Cell Carcinoma:

15
Large undifferentiated cells

Animal Models for Lung Giant Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Lung Giant Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.8TIMP1, MMP2, NME1, CDKN2A, CDH1
2MP:00053797.7TIMP1, PCNA, NME1, CDKN2A, CDH1
3MP:00053767.3CDH1, CDKN2A, NME1, MMP2, TIMP1, TIMP2
4MP:00053977.1CDKN2A, TIMP2, TIMP1, MMP2, IL8, PCNA
5MP:00053876.9TIMP2, TIMP1, MMP2, IL8, PCNA, CDKN2A
6MP:00053786.8TIMP1, MMP2, PCNA, NME1, KRT18, CDKN2A
7MP:00107686.7TIMP1, MMP2, PCNA, NME1, KRT18, CDKN2A

Publications for Lung Giant Cell Carcinoma

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Articles related to Lung Giant Cell Carcinoma:

idTitleAuthorsYear
1
Study on differentially expressed molecules influencing the metastatic potential between highly and poorly metastatic human lung giant cell carcinoma]. (14690554)
2003
2
Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line. (8017834)
1994
3
Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes. (2200751)
1990
4
Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells. (2659722)
1989

Variations for Lung Giant Cell Carcinoma

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Expression for genes affiliated with Lung Giant Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Lung Giant Cell Carcinoma

Search GEO for disease gene expression data for Lung Giant Cell Carcinoma.

Pathways for genes affiliated with Lung Giant Cell Carcinoma

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Pathways related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CDH1, NME1
29.6NME1, CDH1
39.3IL8, MMP2
49.3IL8, MMP2
59.3IL8, MMP2
69.3IL8, MMP2
79.0CDKN2A, MMP2
89.0CDKN2A, PCNA, IL8
98.8CDH1, IL8, MMP2
10
Show member pathways
Cell cycle37
8.8CDH1, CDKN2A, PCNA
11
Show member pathways
8.8MMP2, TIMP1, TIMP2
128.8TIMP2, TIMP1, MMP2
138.8TIMP2, TIMP1, MMP2
14
Show member pathways
8.8TIMP2, TIMP1, IL8, CDH1
15
Show member pathways
8.8TIMP2, TIMP1, IL8, CDH1
16
Show member pathways
8.3TIMP2, TIMP1, MMP2, CDH1
17
Show member pathways
Signaling Pathways in Glioblastoma37
8.2CDH1, CDKN2A, IL8, MMP2
188.2MMP2, IL8, CDKN2A, CDH1
19
Show member pathways
8.2TIMP2, TIMP1, MMP2, CDKN2A
20
Show member pathways
8.2CDKN2A, MMP2, TIMP1, TIMP2
21
Show member pathways
7.9CDH1, IL8, MMP2, TIMP1, TIMP2
22
Show member pathways
7.8TIMP2, TIMP1, IL8, KRT18, CDKN2A, CDH1

Compounds for genes affiliated with Lung Giant Cell Carcinoma

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Compounds related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1chi 2449.3TIMP2, NME1, CDH1
2methyl selenol449.2TIMP2, MMP2, TIMP1
3latanoprost44 1210.1TIMP2, TIMP1, MMP2
4gamma-linolenic acid44 2510.1PCNA, CDH1, TIMP1
5(4-aminophenyl)mercuric acetate449.0TIMP2, TIMP1, MMP2
6norcantharidin449.0TIMP2, MMP2, PCNA
7polycarbonate449.0IL8, CDH1, MMP2
8o6-methylguanine448.8PCNA, CDH1, CDKN2A
9p002448.8TIMP2, TIMP1, NME1, CDH1, KRT18
10hematoxylin448.8CDH1, CDKN2A, PCNA, KRT18
11aprotinin44 129.8MMP2, TIMP1, IL8, TIMP2
12doxycycline44 129.5KRT18, CDKN2A, TIMP1, MMP2
13temozolomide44 129.5MMP2, PCNA, CDKN2A
14mg 13244 609.5PCNA, CDKN2A, KRT18, CDH1, IL8
15actinomycin d448.5TIMP2, IL8, KRT18, TIMP1, CDKN2A
16hydroxamate448.5TIMP2, TIMP1, MMP2
17cytochalasin d44 609.3IL8, TIMP1, CDH1, TIMP2, MMP2
18herbimycin a44 609.3MMP2, TIMP1, TIMP2, CDH1, IL8
19hyaluronic acid44 259.3TIMP2, TIMP1, CDH1, IL8, MMP2
205-aza-2deoxycytidine448.3TIMP2, PCNA, CDKN2A, TIMP1, CDH1
21sb 20358044 609.3TIMP1, CDH1, IL8, TIMP2, MMP2
22paclitaxel44 50 1210.2CDH1, CDKN2A, PCNA, TIMP1, TIMP2
23nitric oxide44 25 1210.2NME1, IL8, KRT18, TIMP2, TIMP1, CDKN2A
24pd 98,059448.2MMP2, TIMP2, TIMP1, IL8, CDH1
25ly294002448.2CDH1, TIMP2, MMP2, TIMP1, IL8
26heparin44 29 25 1211.1IL8, PCNA, TIMP2, CDH1, TIMP1
27etoposide44 50 60 1211.1TIMP1, MMP2, PCNA, NME1, CDH1
28cisplatin44 50 60 1211.1NME1, PCNA, TIMP1, CDH1, CDKN2A
29pge2448.0TIMP2, CDH1, NME1, IL8, MMP2, TIMP1
30dexamethasone44 50 29 1210.7KRT18, NME1, IL8, TIMP1, CDKN2A, CDH1
31butyrate447.7CDH1, PCNA, TIMP2, TIMP1, IL8, KRT18
32h2o2447.7IL8, TIMP1, PCNA, MMP2, TIMP2, CDKN2A
33matrigel447.7MMP2, CDH1, TIMP2, TIMP1, IL8, NME1
34azathioprine44 3 50 1210.6PCNA, CDH1, TIMP2, CDKN2A, MMP2, TIMP1
35methotrexate50 44 129.5CDKN2A, PCNA, MMP2, TIMP2, CDH1, TIMP1
365fluorouracil447.3TIMP2, KRT18, CDH1, MMP2, PCNA, NME1
37n acetylcysteine447.3IL8, CDKN2A, KRT18, CDH1, TIMP1, MMP2
38creatinine447.3MMP2, PCNA, NME1, KRT18, CDKN2A, CDH1
39genistein44 29 60 3 25 1212.2CDH1, TIMP1, CDKN2A, PCNA, IL8, MMP2
40aspartate447.2CDKN2A, KRT18, NME1, PCNA, MMP2, CDH1
41lactate447.1MMP2, CDH1, KRT18, NME1, TIMP2, TIMP1
42serine447.0IL8, TIMP2, MMP2, CDH1, NME1, KRT18
43egcg446.9IL8, PCNA, MMP2, TIMP1, TIMP2, CDKN2A
44cysteine446.9CDKN2A, PCNA, IL8, TIMP1, NME1, MMP2
45paraffin446.8MMP2, CDH1, CDKN2A, KRT18, NME1, PCNA
46progesterone44 29 60 25 1210.8NME1, CDH1, CDKN2A, KRT18, PCNA, MMP2
47alanine446.8CDKN2A, KRT18, NME1, PCNA, MMP2, TIMP1
48estrogen446.8KRT18, NME1, TIMP1, TIMP2, PCNA, CDKN2A
49retinoic acid44 257.8CDKN2A, KRT18, NME1, PCNA, TIMP2, CDH1
50vegf446.5MMP2, IL8, TIMP1, PCNA, NME1, KRT18

GO Terms for genes affiliated with Lung Giant Cell Carcinoma

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Cellular components related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9CDH1, IL8, MMP2, TIMP1, TIMP2

Biological processes related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to cytokineGO:0340979.6TIMP1, TIMP2
2cellular response to amino acid stimulusGO:0712308.8CDH1, MMP2
3negative regulation of cell proliferationGO:0082858.7TIMP2, IL8, NME1, CDKN2A
4extracellular matrix disassemblyGO:0226178.3CDH1, MMP2, TIMP1, TIMP2
5extracellular matrix organizationGO:0301988.3TIMP2, TIMP1, MMP2, CDH1

Molecular functions related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:0081919.6TIMP1, TIMP2
2protein bindingGO:0055155.8CDH1, TIMP2, TIMP1, MMP2, IL8, PCNA

Products for genes affiliated with Lung Giant Cell Carcinoma

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  • Kits and Assays

Sources for Lung Giant Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet