MCID: LNG017
MIFTS: 40

Lung Giant Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Giant Cell Carcinoma

MalaCards integrated aliases for Lung Giant Cell Carcinoma:

Name: Lung Giant Cell Carcinoma 12 14
Carcinoma, Giant Cell 42 69
Giant Cell Carcinoma of Lung 69
Giant Cell Lung Carcinoma 12
Giant Cell Carcinoma 12
Carcinoma Giant Cell 52

Classifications:



External Ids:

Disease Ontology 12 DOID:5583
MeSH 42 D018286
NCIt 47 C3779 C4452
SNOMED-CT 64 254631008 42596004

Summaries for Lung Giant Cell Carcinoma

Disease Ontology : 12 A lung carcinoma that is located in large undifferentiated cells.

MalaCards based summary : Lung Giant Cell Carcinoma, also known as carcinoma, giant cell, is related to lymphomatoid granulomatosis and steatorrhea, and has symptoms including coughing, dyspnea and fever. An important gene associated with Lung Giant Cell Carcinoma is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs nivolumab and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and kidney, and related phenotypes are growth/size/body region and mortality/aging

Related Diseases for Lung Giant Cell Carcinoma

Diseases related to Lung Giant Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
id Related Disease Score Top Affiliating Genes
1 lymphomatoid granulomatosis 10.5 MYC TIMP1
2 steatorrhea 10.5 CXCL8 TIMP1
3 amyotrophic lateral sclerosis type 10 10.4 CDH1 CXCL8
4 collagen disease 10.4 CDH1 NME1
5 gait apraxia 10.4 MMP2 TIMP1
6 ichthyosis, congenital, autosomal recessive 12 10.3 CXCL8 MMP9
7 cribriform carcinoma 10.3 CDH1 KRT18
8 burns 10.3 CXCL8 TIMP1
9 congenital methemoglobinemia 10.3 MMP2 TIMP1
10 thymus clear cell carcinoma 10.3 CXCL8 MMP2
11 follicular mucinosis 10.2 CXCL8 MMP9
12 tumefactive multiple sclerosis 10.2 CXCL8 MMP9
13 mycobacterium gordonae 10.2 CXCL8 MMP9
14 breast adenomyoepithelioma 10.2 MMP9 TIMP1
15 facial arteriovenous malformation 10.2 MMP2 MMP9
16 familial short qt syndrome 10.2 MMP2 MMP9
17 kleptomania 10.2 MMP2 MMP9
18 leucocyte adhesion defect 10.2 MMP2 MMP9
19 uterine corpus dissecting leiomyoma 10.1 CDH1 CXCL8
20 acquired hemangioma 10.1 MMP2 MMP9
21 transitional meningioma 10.1 MMP2 MMP9
22 tinea profunda 10.1 MMP2 MMP9
23 xanthogranulomatous cholecystitis 10.1 MMP2 MMP9
24 myopathy 10.1 CXCL8 MMP9
25 collagenous colitis 10.1 MMP2 MMP9
26 sialadenitis 10.1 MMP2 MMP9
27 ovarian wilms' cancer 10.1 CXCL8 KRT18 MYC
28 corneal staphyloma 10.1 MMP2 MMP9
29 limbic encephalitis 10.1 MMP2 MMP9
30 chancroid 10.1 CXCL8 IL6R
31 nasal cavity adenocarcinoma 10.1 MMP2 MMP9
32 adenosine monophosphate deaminase 1 deficiency 10.1 MMP2 MMP9
33 tuberculous salpingitis 10.1 CXCL8 MMP9 TIMP1
34 osteogenesis imperfecta, type x 10.1 CXCL8 IL6R
35 influenza 10.0 MMP2 MMP9
36 endocervical type cervical mucinous adenocarcinoma 10.0 CXCL8 MMP9 TIMP1
37 burn scar 10.0 CXCL8 MMP9 TIMP1
38 cavernous hemangioma of face 10.0 CDH1 MMP2 TIMP1
39 oligomeganephronic renal hypoplasia 10.0 MMP2 MMP9
40 granulomatous orchitis 10.0 CXCL8 MMP9 TIMP1
41 dental caries 10.0 CDH1 MMP2 NME1
42 nasal cavity disease 10.0 CDH1 MMP2 NME1
43 gastric cancer, somatic 9.9 CDH1 MYC NME1
44 immunodeficiency 27b, mycobacteriosis, ad 9.9 CDH1 MMP9 TIMP1
45 keloids 9.9 IL6R TIMP1
46 drug rash with eosinophilia and systemic symptoms 9.9 CXCL8 MMP2 MMP9
47 tricho onychic dysplasia 9.9 CXCL8 MMP2 MMP9
48 common variable immunodeficiency 9.9 MMP9 MYC TIMP1
49 cecum adenoma 9.9 MMP2 MMP9 TIMP1
50 ladd syndrome 9.9 MMP2 MYC NME1

Graphical network of the top 20 diseases related to Lung Giant Cell Carcinoma:



Diseases related to Lung Giant Cell Carcinoma

Symptoms & Phenotypes for Lung Giant Cell Carcinoma

UMLS symptoms related to Lung Giant Cell Carcinoma:


coughing, dyspnea, fever, hemoptysis

MGI Mouse Phenotypes related to Lung Giant Cell Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.76 NME1 TIMP1 CDH1 IL6R KRT18 MMP2
2 mortality/aging MP:0010768 9.56 CDH1 IL6R KRT18 MMP2 MMP9 MYC
3 neoplasm MP:0002006 9.17 CDH1 IL6R MMP2 MMP9 MYC NME1

Drugs & Therapeutics for Lung Giant Cell Carcinoma

Drugs for Lung Giant Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
3
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
4 Radiopharmaceuticals Phase 1, Phase 2
5
Erlotinib Hydrochloride Phase 2,Phase 1 183319-69-9 176871
6 Protein Kinase Inhibitors Phase 2,Phase 1
7 Antibodies Phase 2
8 Antibodies, Monoclonal Phase 2
9 Immunoglobulins Phase 2
10 Fluorides Phase 1, Phase 2
11 Fluorodeoxyglucose F18 Phase 1, Phase 2
12 Albumin-Bound Paclitaxel Phase 2
13 Antimitotic Agents Phase 2
14 Antineoplastic Agents, Phytogenic Phase 2
15
Octreotide Approved, Investigational Phase 1 83150-76-9 383414 6400441
16
Somatostatin Approved Phase 1 38916-34-6, 51110-01-1 53481605
17
Cediranib Investigational Phase 1 288383-20-0 9933475
18
Maleic acid Experimental Phase 1 110-16-7 444266
19 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
20 Liver Extracts Phase 1
21 Antineoplastic Agents, Hormonal Phase 1
22 Edotreotide Phase 1
23 Gastrointestinal Agents Phase 1
24 Hormones Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
2 18F FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy Recruiting NCT01806675 Phase 1, Phase 2 fludeoxyglucose F 18;2-fluoropropionyl-labeled pegylated dimeric RGD peptide
3 TARCEVA (Erlotinib) in Combination With Chemoradiation in Patients With Stage IIIA/B Non-Small Cell Lung Cancer (NSCLC) Active, not recruiting NCT00563784 Phase 2 Erlotinib;Carboplatin;Paclitaxel
4 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
5 Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors Completed NCT01131234 Phase 1 Gamma-Secretase Inhibitor RO4929097;Cediranib Maleate
6 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
7 Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung Carcinoma Unknown status NCT00568906

Search NIH Clinical Center for Lung Giant Cell Carcinoma

Cochrane evidence based reviews: carcinoma, giant cell

Genetic Tests for Lung Giant Cell Carcinoma

Anatomical Context for Lung Giant Cell Carcinoma

MalaCards organs/tissues related to Lung Giant Cell Carcinoma:

39
Lung, Liver, Kidney

Publications for Lung Giant Cell Carcinoma

Articles related to Lung Giant Cell Carcinoma:

id Title Authors Year
1
Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma. ( 28159994 )
2017
2
Epidemiological features of lung giant cell carcinoma and therapy for patients with EGFR mutations based on case reports and the surveillance, epidemiology, and end results (SEER) database. ( 28445978 )
2017
3
[Study on differentially expressed molecules influencing the metastatic potential between highly and poorly metastatic human lung giant cell carcinoma]. ( 14690554 )
2003
4
Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line. ( 8017834 )
1994
5
Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes. ( 2200751 )
1990
6
Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells. ( 2659722 )
1989

Variations for Lung Giant Cell Carcinoma

Cosmic variations for Lung Giant Cell Carcinoma:

9 (show top 50) (show all 80)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM905 RB1 lung,NS,carcinoma,giant cell carcinoma c.245C>A p.S82* 14
2 COSM516 KRAS lung,NS,carcinoma,giant cell carcinoma c.34G>T p.G12C 14
3 COSM6224 EGFR lung,NS,carcinoma,giant cell carcinoma c.2573T>G p.L858R 14
4 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 11
5 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 11
6 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 11
7 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 11
8 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 11
9 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 11
10 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 11
11 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 11
12 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 11
13 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 11
14 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 11
15 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 11
16 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 11
17 COSM43750 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 11
18 COSM43753 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 11
19 COSM95367 TLR5 lung,NS,carcinoma,undifferentiated carcinoma c.1A>G p.M1V 11
20 COSM95359 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 11
21 COSM95356 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 11
22 COSM95347 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 11
23 COSM95342 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 11
24 COSM95340 TLE4 lung,NS,carcinoma,undifferentiated carcinoma c.859A>C p.K287Q 11
25 COSM95334 TIAM1 lung,NS,carcinoma,undifferentiated carcinoma c.3718G>C p.E1240Q 11
26 COSM95292 STK38 lung,NS,carcinoma,undifferentiated carcinoma c.407C>G p.A136G 11
27 COSM95282 STAT1 lung,NS,carcinoma,undifferentiated carcinoma c.2042A>T p.Y681F 11
28 COSM95276 SPRY2 lung,NS,carcinoma,undifferentiated carcinoma c.652T>C p.C218R 11
29 COSM95270 SPOP lung,NS,carcinoma,undifferentiated carcinoma c.570A>C p.L190F 11
30 COSM94327 RNF145 lung,NS,carcinoma,undifferentiated carcinoma c.647G>A p.G216E 11
31 COSM95658 RIN1 lung,NS,carcinoma,undifferentiated carcinoma c.1210C>T p.Q404* 11
32 COSM95187 RICTOR lung,NS,carcinoma,undifferentiated carcinoma c.1711C>A p.H571N 11
33 COSM96136 PLCG1 lung,NS,carcinoma,undifferentiated carcinoma c.3366C>T p.D1122D 11
34 COSM95013 PKHD1 lung,NS,carcinoma,undifferentiated carcinoma c.2753C>A p.P918Q 11
35 COSM94967 PIK3C2A lung,NS,carcinoma,undifferentiated carcinoma c.3240A>T p.E1080D 11
36 COSM94958 PDIA4 lung,NS,carcinoma,undifferentiated carcinoma c.1735G>T p.V579F 11
37 COSM96110 PAX6 lung,NS,carcinoma,undifferentiated carcinoma c.372G>T p.G124G 11
38 COSM94918 PARP1 lung,NS,carcinoma,undifferentiated carcinoma c.790C>G p.L264V 11
39 COSM94897 P2RY1 lung,NS,carcinoma,undifferentiated carcinoma c.238A>G p.M80V 11
40 COSM94878 NTSR1 lung,NS,carcinoma,undifferentiated carcinoma c.808G>T p.A270S 11
41 COSM94867 NRG3 lung,NS,carcinoma,undifferentiated carcinoma c.490G>T p.A164S 11
42 COSM94848 NOTCH2 lung,NS,carcinoma,undifferentiated carcinoma c.5637G>A p.M1879I 11
43 COSM95032 MED1 lung,NS,carcinoma,undifferentiated carcinoma c.2444A>G p.H815R 11
44 COSM94685 MC5R lung,NS,carcinoma,undifferentiated carcinoma c.458T>C p.I153T 11
45 COSM94681 MAX lung,NS,carcinoma,undifferentiated carcinoma c.368A>G p.Y123C 11
46 COSM94657 MAML1 lung,NS,carcinoma,undifferentiated carcinoma c.2605C>A p.Q869K 11
47 COSM94614 LMTK2 lung,NS,carcinoma,undifferentiated carcinoma c.2931C>A p.S977R 11
48 COSM95625 LHCGR lung,NS,carcinoma,undifferentiated carcinoma c.1660C>T p.R554* 11
49 COSM520 KRAS lung,NS,carcinoma,undifferentiated carcinoma c.35G>T p.G12V 11
50 COSM95622 KIF27 lung,NS,carcinoma,undifferentiated carcinoma c.620C>G p.S207* 11

Expression for Lung Giant Cell Carcinoma

Search GEO for disease gene expression data for Lung Giant Cell Carcinoma.

Pathways for Lung Giant Cell Carcinoma

Pathways related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 35)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CDH1 CXCL8 IL6R MMP2 MMP9 MYC
2
Show member pathways
13.1 CXCL8 IL6R MMP2 MMP9 MYC TIMP1
3
Show member pathways
12.55 CDH1 MMP2 MMP9 TIMP1
4 12.4 CDH1 CXCL8 MMP2 MMP9 MYC
5
Show member pathways
12.14 CXCL8 IL6R MMP9
6 12.11 MMP2 MMP9 MYC
7 12.04 CXCL8 MMP9 MYC
8 11.87 CDH1 IL6R MMP2 MMP9 MYC
9 11.84 CXCL8 MMP9 MYC
10 11.78 CDH1 MMP2 MMP9
11
Show member pathways
11.73 MMP2 MMP9 TIMP1
12 11.66 MMP2 MMP9 TIMP1
13
Show member pathways
11.65 IL6R MYC TIMP1
14 11.61 MMP9 MYC NME1
15 11.48 CXCL8 MMP2 MMP9
16 11.47 CXCL8 MMP2 MMP9 TIMP1
17
Show member pathways
11.45 CXCL8 MMP2 MMP9
18 11.45 CDH1 CXCL8 MMP2 MMP9 MYC
19
Show member pathways
11.44 MMP2 MMP9 MYC
20 11.41 CXCL8 MMP2 MMP9 TIMP1
21 11.35 MMP2 MMP9
22 11.34 CXCL8 IL6R MYC
23 11.33 CDH1 MMP9
24
Show member pathways
11.31 MMP2 MMP9
25 11.3 CDH1 NME1
26 11.22 CDH1 CXCL8 MMP2 MMP9 MYC
27 11.21 MMP2 MYC
28 11.18 MMP2 MMP9
29 11.16 CDH1 NME1
30 11.16 CXCL8 MMP2
31 11.16 CXCL8 IL6R MMP2 MMP9 MYC TIMP1
32 11.14 CXCL8 MMP2 MMP9
33 11.03 MMP2 MMP9
34 11.01 MMP9 TIMP1
35 11.01 MMP2 MMP9

GO Terms for Lung Giant Cell Carcinoma

Cellular components related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 CDH1 CXCL8 IL6R MMP2 MMP9 TIMP1

Biological processes related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 embryo implantation GO:0007566 9.4 MMP2 MMP9
2 extrinsic apoptotic signaling pathway GO:0097191 9.37 IL6R KRT18
3 positive regulation of DNA binding GO:0043388 9.32 MMP9 NME1
4 endodermal cell differentiation GO:0035987 9.26 MMP2 MMP9
5 negative regulation of apoptotic process GO:0043066 9.26 KRT18 MMP9 MYC TIMP1
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.16 MMP2 MMP9
7 extracellular matrix disassembly GO:0022617 8.92 CDH1 MMP2 MMP9 TIMP1

Sources for Lung Giant Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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