MCID: LNG017
MIFTS: 39

Lung Giant Cell Carcinoma malady

Respiratory diseases, Cancer diseases categories

Aliases & Classifications for Lung Giant Cell Carcinoma

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Aliases & Descriptions for Lung Giant Cell Carcinoma:

Name: Lung Giant Cell Carcinoma 8
Giant Cell Carcinoma of Lung 61
Giant Cell Lung Carcinoma 8
 
Carcinoma, Giant Cell 61
Giant Cell Carcinoma 8


Classifications:



External Ids:

Disease Ontology8 DOID:5583
NCIt39 C3779
SNOMED-CT56 254631008, 42596004
MeSH33 D018286

Summaries for Lung Giant Cell Carcinoma

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Wikipedia:64 Giant cell carcinoma of the lung (GCCL) is a rare histological form of large-cell lung carcinoma, a... more...

MalaCards based summary: Lung Giant Cell Carcinoma, also known as giant cell carcinoma of lung, is related to hepatitis and choriocarcinoma. An important gene associated with Lung Giant Cell Carcinoma is IL8 (interleukin 8), and among its related pathways are E-cadherin signaling in the nascent adherens junction and Arf6 trafficking events. The compounds chi 2 and methyl selenol have been mentioned in the context of this disorder. Affiliated tissues include large undifferentiated cells and lung, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Disease Ontology:8 A lung carcinoma that is located in large undifferentiated cells.

Related Diseases for Lung Giant Cell Carcinoma

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Diseases related to Lung Giant Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.1TIMP2, KRT18
2choriocarcinoma29.8TIMP2, MMP2, TIMP1, KRT18
3fibromatosis10.5TIMP2
4pulpitis10.4TIMP1
5actinic keratosis10.4PCNA
6alcoholic hepatitis10.3KRT18, IL8
7arthropathy10.3TIMP1
8bronchopulmonary dysplasia10.3IL8, TIMP1
9arthritis10.3IL8, TIMP1
10monocytic leukemia10.3IL8
11oxyphilic adenoma10.3NME1, KRT18
12keratoacanthoma10.3PCNA, NME1
13leukoplakia10.2NME1, PCNA
14smooth muscle tumor10.2NME1, PCNA
15vitreoretinopathy, neovascular inflammatory10.2TIMP2, TIMP1
16gestational trophoblastic neoplasm10.2PCNA, NME1
17renal cell carcinoma10.2CDH1
18bronchiolo-alveolar adenocarcinoma10.2TIMP2, CDH1
19myelofibrosis10.2TIMP2, TIMP1
20pleomorphic adenoma10.2KRT18, PCNA
21laryngeal carcinoma10.2PCNA, NME1
22tongue squamous cell carcinoma10.2NME1, CDH1
23cervical adenocarcinoma10.2NME1, CDKN2A
24acquired immunodeficiency syndrome10.2
25neuroendocrine tumor10.2CDH1, KRT18
26renal fibrosis10.2TIMP1, CDH1
27cervical intraepithelial neoplasia10.2NME1, CDKN2A
28follicular adenoma10.2CDH1, NME1
29cervical squamous cell carcinoma10.2CDKN2A, TIMP2
30pulmonary fibrosis, idiopathic10.2KRT18, IL8, TIMP1
31microvascular complications of diabetes 110.1TIMP2, TIMP1, IL8
32periodontitis10.1TIMP2, IL8, TIMP1
33synovitis10.1IL8, TIMP1, TIMP2
34salivary gland adenoid cystic carcinoma10.1PCNA, CDH1
35nasopharynx carcinoma10.1CDH1, CDKN2A
36gastritis10.1PCNA, KRT18, IL8
37breast ductal carcinoma10.1NME1, TIMP2, CDH1
38papillary carcinoma10.1KRT18, NME1, CDH1
39breast fibroadenoma10.1NME1, TIMP2, PCNA
40liver cirrhosis10.1TIMP2, KRT18, TIMP1
41gastric adenocarcinoma10.1NME1, CDH1, TIMP2
42neuroendocrine carcinoma10.1
43cystadenoma10.1
44large cell neuroendocrine carcinoma10.1
45follicular dendritic cell sarcoma10.1
46gynecomastia10.1
47pseudomyxoma peritonei10.1
48small cell carcinoma10.1
49dendritic cell sarcoma10.1
50esophagitis10.1

Graphical network of the top 20 diseases related to Lung Giant Cell Carcinoma:



Diseases related to lung giant cell carcinoma

Symptoms for Lung Giant Cell Carcinoma

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Drugs & Therapeutics for Lung Giant Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Lung Giant Cell Carcinoma

Search NIH Clinical Center for Lung Giant Cell Carcinoma

Genetic Tests for Lung Giant Cell Carcinoma

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Anatomical Context for Lung Giant Cell Carcinoma

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MalaCards organs/tissues related to Lung Giant Cell Carcinoma:

31
Lung

FMA organs/tissues related to Lung Giant Cell Carcinoma:

14
Large undifferentiated cells

Animal Models for Lung Giant Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Lung Giant Cell Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.8TIMP1, MMP2, NME1, CDKN2A, CDH1
2MP:00053797.7TIMP1, PCNA, NME1, CDKN2A, CDH1
3MP:00053767.3CDH1, CDKN2A, NME1, MMP2, TIMP1, TIMP2
4MP:00053977.1CDKN2A, TIMP2, TIMP1, MMP2, IL8, PCNA
5MP:00053876.9TIMP2, TIMP1, MMP2, IL8, PCNA, CDKN2A
6MP:00053786.8TIMP1, MMP2, PCNA, NME1, KRT18, CDKN2A
7MP:00107686.7TIMP1, MMP2, PCNA, NME1, KRT18, CDKN2A

Publications for Lung Giant Cell Carcinoma

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Articles related to Lung Giant Cell Carcinoma:

idTitleAuthorsYear
1
Study on differentially expressed molecules influencing the metastatic potential between highly and poorly metastatic human lung giant cell carcinoma]. (14690554)
2003
2
Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line. (8017834)
1994
3
Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes. (2200751)
1990
4
Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells. (2659722)
1989

Expression for genes affiliated with Lung Giant Cell Carcinoma

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Search GEO for disease gene expression data for Lung Giant Cell Carcinoma.

Pathways for genes affiliated with Lung Giant Cell Carcinoma

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Pathways related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6NME1, CDH1
29.6CDH1, NME1
39.3IL8, MMP2
49.3IL8, MMP2
59.3IL8, MMP2
69.3MMP2, IL8
79.0MMP2, CDKN2A
89.0IL8, CDKN2A, PCNA
98.8CDH1, MMP2, IL8
10
Show member pathways
Cell cycle36
8.8PCNA, CDKN2A, CDH1
11
Show member pathways
8.8MMP2, TIMP2, TIMP1
128.8TIMP2, TIMP1, MMP2
138.8TIMP2, TIMP1, MMP2
14
Show member pathways
8.8TIMP2, CDH1, IL8, TIMP1
15
Show member pathways
8.8TIMP2, CDH1, TIMP1, IL8
16
Show member pathways
8.3CDH1, TIMP2, MMP2, TIMP1
178.2CDH1, MMP2, IL8, CDKN2A
18
Show member pathways
Signaling Pathways in Glioblastoma36
8.2MMP2, IL8, CDKN2A, CDH1
19
Show member pathways
8.2TIMP2, CDKN2A, MMP2, TIMP1
20
Show member pathways
8.2TIMP2, TIMP1, CDKN2A, MMP2
21
Show member pathways
Metalloproteases in connective tissue degradation
7.9TIMP1, MMP2, IL8, TIMP2, CDH1
22
Show member pathways
7.8KRT18, IL8, CDKN2A, CDH1, TIMP1, TIMP2

Compounds for genes affiliated with Lung Giant Cell Carcinoma

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Compounds related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1chi 2449.3TIMP2, NME1, CDH1
2methyl selenol449.2TIMP2, MMP2, TIMP1
3latanoprost44 1110.1TIMP2, TIMP1, MMP2
4gamma-linolenic acid44 2410.1PCNA, CDH1, TIMP1
5(4-aminophenyl)mercuric acetate449.0TIMP2, TIMP1, MMP2
6norcantharidin449.0TIMP2, MMP2, PCNA
7polycarbonate449.0IL8, CDH1, MMP2
8o6-methylguanine448.8PCNA, CDH1, CDKN2A
9p002448.8TIMP2, TIMP1, NME1, CDH1, KRT18
10hematoxylin448.8CDH1, CDKN2A, PCNA, KRT18
11aprotinin44 119.8MMP2, TIMP1, IL8, TIMP2
12doxycycline44 119.5KRT18, CDKN2A, TIMP1, MMP2
13temozolomide44 119.5MMP2, PCNA, CDKN2A
14mg 13244 609.5PCNA, CDKN2A, KRT18, CDH1, IL8
15actinomycin d448.5TIMP2, IL8, KRT18, TIMP1, CDKN2A
16hydroxamate448.5TIMP2, TIMP1, MMP2
17cytochalasin d44 609.3IL8, TIMP1, CDH1, TIMP2, MMP2
18herbimycin a44 609.3MMP2, TIMP1, TIMP2, CDH1, IL8
19hyaluronic acid44 249.3TIMP2, TIMP1, CDH1, IL8, MMP2
205-aza-2deoxycytidine448.3TIMP2, PCNA, CDKN2A, TIMP1, CDH1
21sb 20358044 609.3TIMP1, CDH1, IL8, TIMP2, MMP2
22paclitaxel44 50 1110.2CDH1, CDKN2A, PCNA, TIMP1, TIMP2
23nitric oxide44 24 1110.2NME1, IL8, KRT18, TIMP2, TIMP1, CDKN2A
24pd 98,059448.2MMP2, TIMP2, TIMP1, IL8, CDH1
25ly294002448.2CDH1, TIMP2, MMP2, TIMP1, IL8
26heparin44 28 24 1111.1IL8, PCNA, TIMP2, CDH1, TIMP1
27etoposide44 50 60 1111.1TIMP1, MMP2, PCNA, NME1, CDH1
28cisplatin44 50 60 1111.1NME1, PCNA, TIMP1, CDH1, CDKN2A
29pge2448.0TIMP2, CDH1, NME1, IL8, MMP2, TIMP1
30dexamethasone44 50 28 1110.7KRT18, NME1, IL8, TIMP1, CDKN2A, CDH1
31butyrate447.7CDH1, PCNA, TIMP2, TIMP1, IL8, KRT18
32h2o2447.7IL8, TIMP1, PCNA, MMP2, TIMP2, CDKN2A
33matrigel447.7MMP2, CDH1, TIMP2, TIMP1, IL8, NME1
34azathioprine44 1 50 1110.6PCNA, CDH1, TIMP2, CDKN2A, MMP2, TIMP1
35methotrexate50 44 119.5CDKN2A, PCNA, MMP2, TIMP2, CDH1, TIMP1
365fluorouracil447.3TIMP2, KRT18, CDH1, MMP2, PCNA, NME1
37n acetylcysteine447.3IL8, CDKN2A, KRT18, CDH1, TIMP1, MMP2
38creatinine447.3MMP2, PCNA, NME1, KRT18, CDKN2A, CDH1
39genistein44 28 60 1 24 1112.2CDH1, TIMP1, CDKN2A, PCNA, IL8, MMP2
40aspartate447.2CDKN2A, KRT18, NME1, PCNA, MMP2, CDH1
41lactate447.1MMP2, CDH1, KRT18, NME1, TIMP2, TIMP1
42serine447.0IL8, TIMP2, MMP2, CDH1, NME1, KRT18
43egcg446.9IL8, PCNA, MMP2, TIMP1, TIMP2, CDKN2A
44cysteine446.9CDKN2A, PCNA, IL8, TIMP1, NME1, MMP2
45paraffin446.8MMP2, CDH1, CDKN2A, KRT18, NME1, PCNA
46progesterone44 28 60 24 1110.8NME1, CDH1, CDKN2A, KRT18, PCNA, MMP2
47alanine446.8CDKN2A, KRT18, NME1, PCNA, MMP2, TIMP1
48estrogen446.8KRT18, NME1, TIMP1, TIMP2, PCNA, CDKN2A
49retinoic acid44 247.8CDKN2A, KRT18, NME1, PCNA, TIMP2, CDH1
50vegf446.5MMP2, IL8, TIMP1, PCNA, NME1, KRT18

GO Terms for genes affiliated with Lung Giant Cell Carcinoma

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Cellular components related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.9CDH1, IL8, MMP2, TIMP1, TIMP2

Biological processes related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to cytokineGO:00340979.6TIMP1, TIMP2
2cellular response to amino acid stimulusGO:00712308.8CDH1, MMP2
3negative regulation of cell proliferationGO:00082858.7TIMP2, IL8, NME1, CDKN2A
4extracellular matrix disassemblyGO:00226178.3CDH1, MMP2, TIMP1, TIMP2
5extracellular matrix organizationGO:00301988.3TIMP2, TIMP1, MMP2, CDH1

Molecular functions related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:00081919.6TIMP1, TIMP2
2protein bindingGO:00055155.8CDH1, TIMP2, TIMP1, MMP2, IL8, PCNA

Sources for Lung Giant Cell Carcinoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet