Lung Giant Cell Carcinoma malady

Wikipedia: Giant cell carcinoma of the lung (GCCL) is a rare histological form of undifferentiated lung cancer...⁴⁴ more...

MalaCards: Lung Giant Cell Carcinoma, also known as giant cell carcinoma (morphologic abnormality), is related to renal cell carcinoma and squamous cell carcinoma. An important gene associated with Lung Giant Cell Carcinoma is IL8 (interleukin 8), and among its related pathways are Protein Stability and Activation of Matrix Metalloproteinases. The drugs carmustine and diethylstilbestrol diphosphate and the compounds pge2 and aprotinin have been mentioned in the context of this disorder. Affiliated tissues include large undifferentiated cells and lung, and related mouse phenotypes are hematopoietic system and tumorigenesis.

Disease Ontology: A lung carcinoma that is located in large undifferentiated cells.⁶

Aliases & Descriptions:

lung giant cell carcinoma 6 8 giant cell carcinoma (morphologic abnormality) 6 gip - giant cell interstitial pneumonitis 43 giant cell carcinoma of lung (disorder) 6 giant cell carcinoma of lung 43

giant cell lung carcinoma 6 carcinoma, giant cell 43 giant cell carcinoma 6 carcinoma giant cell 32 carcinoma 43

Diseases related to lung giant cell carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1300)

id	Related Disease	Score	Top Affiliating Genes
1	renal cell carcinoma	37.1	PCNA, CDH1, MMP2, KRT18, TIMP2, NME1
2	squamous cell carcinoma	36.2	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
3	colon carcinoma	36.1	CDH1, MMP2, IL8, KRT18, TIMP2, NME1
4	hepatocellular carcinoma	36.0	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
5	breast carcinoma	34.9	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
6	esophageal squamous cell carcinoma	34.9	PCNA, CDKN2A, CDH1, MMP2, IL8, NME1
7	non-small cell lung carcinoma	34.8	PCNA, CDKN2A, KRT18, NME1
8	thyroid carcinoma	34.4	PCNA, CDKN2A, CDH1, MMP2, KRT18, TIMP1
9	pancreatic carcinoma	34.3	PCNA, CDKN2A, CDH1, MMP2, IL8
10	small cell carcinoma	33.9	PCNA, CDKN2A, CDH1, KRT18
11	esophagitis	33.9	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
12	renal carcinoma	33.8	PCNA, CDKN2A, CDH1, NME1
13	ovarian carcinoma	33.7	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
14	ductal carcinoma in situ	33.5	PCNA, CDKN2A, CDH1, TIMP2
15	cervical carcinoma	33.5	PCNA, CDKN2A, CDH1, MMP2, KRT18, TIMP2
16	clear cell renal cell carcinoma	33.3	CDH1, MMP2, TIMP2
17	squamous cell carcinoma of the head and neck	33.2	PCNA, CDKN2A, CDH1, MMP2, KRT18, NME1
18	papillary thyroid carcinoma	33.1	PCNA, CDKN2A, CDH1, MMP2, TIMP1, TIMP2
19	neuroendocrine carcinoma	33.1	PCNA, CDKN2A, CDH1, KRT18
20	prostate carcinoma	33.0	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
21	oral squamous cell carcinoma	33.0	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
22	bladder carcinoma	33.0	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
23	merkel cell carcinoma	32.9	PCNA, CDKN2A, CDH1, KRT18
24	endometrial carcinoma	32.6	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
25	mucoepidermoid carcinoma	32.6	PCNA, CDH1, MMP2
26	cervicitis	32.5	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
27	nasopharyngitis	32.5	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
28	laryngitis	32.4	PCNA, CDKN2A, CDH1, MMP2, IL8, TIMP1
29	breast cancer	32.2	MMP2, IL8, TIMP2
30	laryngeal squamous cell carcinoma	32.1	PCNA, CDKN2A, CDH1, MMP2, TIMP1, NME1
31	basal cell carcinoma	32.0	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
32	esophageal carcinoma	32.0	PCNA, CDKN2A, CDH1, MMP2, TIMP1, NME1
33	cervical squamous cell carcinoma	31.9	CDKN2A, MMP2, TIMP2
34	pancreatitis	31.8	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
35	adenoid cystic carcinoma	31.6	PCNA, CDKN2A, CDH1, MMP2, TIMP1, TIMP2
36	hepatitis	31.5	PCNA, CDKN2A, CDH1, MMP2, IL2RG, IL8
37	multiple endocrine neoplasia	31.4	CDKN2A, CDH1, NME1
38	gallbladder carcinoma	31.3	PCNA, CDKN2A, CDH1, MMP2, TIMP2, NME1
39	anaplastic carcinoma	31.2	CDH1, KRT18, NME1
40	adenoiditis	31.1	PCNA, CDKN2A, CDH1, MMP2, IL8, TIMP1
41	hypoxia	30.9	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
42	adenoma	30.9	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
43	laryngeal carcinoma	30.7	PCNA, CDKN2A, CDH1, MMP2, IL8, TIMP1
44	adenocarcinoma	30.5	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
45	verrucous carcinoma	30.5	PCNA, CDKN2A, CDH1
46	skin carcinoma	30.4	CDH1, MMP2, KRT18
47	basaloid squamous cell carcinoma	30.4	PCNA, CDKN2A, CDH1
48	stomach carcinoma	30.3	CDKN2A, CDH1
49	papilloma	30.2	PCNA, CDKN2A, MMP2, TIMP2
50	hepatitis b	30.1	PCNA, CDKN2A, CDH1, MMP2, IL2RG, IL8

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, nilutamide

MalaCards organs/tissues related to lung giant cell carcinoma:

²²

FMA organs/tissues related to lung giant cell carcinoma:

¹¹

MGI Mouse Phenotypes related to lung giant cell carcinoma:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	7.6	TIMP2, TIMP1, IL8, IL2RG, CDKN2A, PCNA
2	tumorigenesis	MP:0002006	7.1	CDKN2A, CDH1, MMP2, IL2RG, TIMP1, NME1

Articles related to lung giant cell carcinoma:

id	Title	Authors	Year	Affiliating Genes
1	Study on differentially expressed molecules influencing the metastatic potential between highly and poorly metastatic human lung giant cell carcinoma (14690554)	Jiang D.F.... He F.C.	2003	CDH1, MMP2, PCNA
2	Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes. (2200751)	Hotta K.... Suzuki K.	1990	IL8
3	Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells. (2659722)	Suzuki K.... Mizuno S.	1989	IL8

Genes related to lung giant cell carcinoma according to GeneCards:

(show all 12)

id	Symbol	Description	Score	GeneCards Section Context
1	IL8	interleukin 8	11.1	Publications, Aliases & Descriptions
2	HDAC10	histone deacetylase 10	11.0
3	SLC25A11	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	11.0
4	IL2RG	interleukin 2 receptor, gamma	11.0
5	KRT18	keratin 18	11.0	Publications
6	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
7	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
8	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
9	PCNA	proliferating cell nuclear antigen	11.0	Publications
10	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
11	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
12	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications

Pathways related to lung giant cell carcinoma according to GeneDecks:

(show all 17)

id	Pathway	Score	Top Affiliating Genes
1	Protein Stability3	10.0	TIMP1
2	Activation of Matrix Metalloproteinases38	9.3	MMP2, TIMP1, TIMP2
3	Inhibition of Matrix Metalloproteinases36	9.2	MMP2, TIMP1, TIMP2
4	Angiogenesis3	9.2	TIMP2, TIMP1, MMP2
5	Pathways in cancer20	9.2	CDH1, MMP2
6	MAPK Family Pathway36	9.2	TIMP2, TIMP1, IL8, IL2RG
7	JAK-STAT Pathway36	9.1	IL2RG, IL8, TIMP1, TIMP2
8	Tec Kinases Signaling36	9.1	TIMP2, TIMP1, IL8, IL2RG
9	Cell adhesion_ECM remodeling41	9.0	TIMP2, TIMP1, IL8, MMP2
10	p38 Signaling36	9.0	IL2RG, IL8, TIMP1, TIMP2
11	Cell adhesion ECM remodeling10	9.0	TIMP2, TIMP1, IL8, MMP2
12	Antioxidant Action of Vitamin-C36	8.7	TIMP2, TIMP1, IL8, IL2RG
13	Pancreatic Adenocarcinoma36	8.7	TIMP2, TIMP1, MMP2, CDKN2A
14	Bladder cancer20	8.6	CDKN2A, CDH1, MMP2, IL8
15	TGF-Beta Pathway36	8.5	TIMP2, TIMP1, IL8, IL2RG, CDH1
16	ILK Signaling36	8.3	CDH1, KRT18, TIMP1, TIMP2
17	Molecular Mechanisms of Cancer36	8.2	TIMP2, TIMP1, IL2RG, CDH1, CDKN2A

Compounds related to lung giant cell carcinoma according to GeneDecks:

(show top 50)    (show all 105)

id	Compound	Score	Top Affiliating Genes
1	pge232	10.0	CDH1
2	aprotinin32 9 9	11.7	MMP2, TIMP2
3	egcg32	9.7	TIMP2, TIMP1, KRT18
4	polycarbonate32	9.7	IL8, CDH1
5	methyl selenol32	9.4	TIMP2, TIMP1, MMP2
6	latanoprost32 9 9	11.3	TIMP2, TIMP1, MMP2
7	(4-aminophenyl)mercuric acetate32	9.3	TIMP2, TIMP1, MMP2
8	norcantharidin32	9.3	PCNA, TIMP2, MMP2
9	chi 232	9.2	TIMP2, CDH1, NME1
10	progesterone32 42 9 18 9	13.1	CDKN2A, PCNA, KRT18, NME1
11	hydroxamate32	9.1	MMP2, TIMP1, TIMP2
12	s-allylcysteine32	9.1	PCNA, CDH1
13	temozolomide32 9 9	11.0	PCNA, CDKN2A, MMP2
14	gamma-linolenic acid32 18	9.9	PCNA, CDH1, TIMP1
15	doxycycline32 9 9	10.9	TIMP1, CDKN2A, MMP2, KRT18
16	retinoic acid32 42 18	10.8	TIMP1, TIMP2, KRT18, CDKN2A, NME1
17	crcs32	8.8	NME1, CDKN2A, CDH1
18	o6-methylguanine32	8.7	CDKN2A, PCNA, CDH1
19	p0000132	8.6	TIMP2, CDH1, CDKN2A
20	hematoxylin32	8.6	CDH1, CDKN2A, KRT18, PCNA
21	actinomycin d32	8.6	IL8, TIMP2, CDKN2A, KRT18, TIMP1
22	p00232	8.5	CDH1, KRT18, NME1, TIMP2, TIMP1
23	aspartate32	8.4	MMP2, PCNA, CDKN2A, CDH1
24	mg 13232 42	9.4	KRT18, CDKN2A, CDH1, PCNA, IL8
25	cytochalasin d32 42	9.3	MMP2, IL8, TIMP1, TIMP2, CDH1
26	herbimycin a32 42	9.3	CDH1, MMP2, IL8, TIMP2, TIMP1
27	hyaluronic acid32 18	9.3	CDH1, MMP2, IL8, TIMP2, TIMP1
28	cyclosporin a32 42	9.2	PCNA, TIMP2, TIMP1, IL8, IL2RG
29	sb 20358032 42	9.2	TIMP2, IL8, MMP2, CDH1, TIMP1
30	5-aza-2deoxycytidine32	8.1	CDH1, TIMP2, PCNA, CDKN2A, TIMP1
31	pd 98,05932	8.1	IL8, CDH1, TIMP1, MMP2, TIMP2
32	ly29400232	8.1	TIMP2, CDH1, MMP2, TIMP1, IL8
33	paclitaxel32 34 9 9	11.0	TIMP1, PCNA, CDH1, CDKN2A, TIMP2
34	etoposide32 42 9 9	11.0	NME1, TIMP1, CDH1, PCNA, MMP2
35	matrigel32	7.6	MMP2, CDH1, IL8, KRT18, TIMP1, TIMP2
36	azathioprine32 34 9 9	10.6	TIMP2, CDKN2A, TIMP1, CDH1, MMP2, PCNA
37	butyrate32	7.6	PCNA, TIMP2, TIMP1, KRT18, CDKN2A, CDH1
38	methotrexate32 34 42 9 9	11.5	TIMP1, TIMP2, CDKN2A, PCNA, CDH1, MMP2
39	dexamethasone32 42 34 9 9	11.5	TIMP1, PCNA, CDKN2A, CDH1, IL8, KRT18
40	n acetylcysteine32	7.4	MMP2, CDH1, CDKN2A, PCNA, TIMP1, KRT18
41	5fluorouracil32	7.3	PCNA, KRT18, CDKN2A, CDH1, MMP2, TIMP2
42	genistein32 9 18 9	10.3	CDKN2A, TIMP2, TIMP1, IL8, MMP2, CDH1
43	creatinine32	7.3	PCNA, CDKN2A, CDH1, MMP2, TIMP2, NME1
44	cysteine32	7.1	TIMP1, NME1, MMP2, CDH1, CDKN2A, PCNA
45	lactate32	7.1	PCNA, CDH1, MMP2, IL8, KRT18, NME1
46	serine32	6.9	CDH1, MMP2, IL8, KRT18, TIMP1, NME1
47	paraffin32	6.9	KRT18, CDKN2A, CDH1, MMP2, TIMP1, TIMP2
48	alanine32	6.8	NME1, PCNA, CDKN2A, CDH1, MMP2, KRT18
49	estrogen32	6.8	PCNA, CDKN2A, CDH1, MMP2, KRT18, TIMP1
50	vegf32	6.6	PCNA, NME1, TIMP2, TIMP1, IL8, MMP2

Biological processes related to lung giant cell carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix organization	GO:030198	9.0	MMP2, TIMP1, TIMP2
2	extracellular matrix disassembly	GO:022617	8.9	MMP2, TIMP1, TIMP2
3	negative regulation of cell proliferation	GO:008285	8.6	NME1, TIMP2, IL8, CDKN2A

Molecular functions related to lung giant cell carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	metalloendopeptidase inhibitor activity	GO:008191	9.6	TIMP1, TIMP2
2	protein binding	GO:005515	5.6	PCNA, HDAC10, NME1, TIMP1, KRT18, IL8