MCID: LNG017
MIFTS: 43

Lung Giant Cell Carcinoma malady

Respiratory, Cancer categories

Summaries for Lung Giant Cell Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Giant cell carcinoma of the lung (GCCL) is a rare histological form of undifferentiated lung cancer... more...

MalaCards: Lung Giant Cell Carcinoma, also known as giant cell carcinoma of lung, is related to papillary carcinoma and bladder carcinoma. An important gene associated with Lung Giant Cell Carcinoma is IL8 (interleukin 8), and among its related pathways are Glioma and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. The compounds (4-aminophenyl)mercuric acetate and matrigel have been mentioned in the context of this disorder. Affiliated tissues include large undifferentiated cells, lung and thyroid, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:8 A lung carcinoma that is located in large undifferentiated cells.

Aliases & Classifications for Lung Giant Cell Carcinoma

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Respiratory


Aliases & Descriptions:

lung giant cell carcinoma 8
giant cell carcinoma of lung 8 61
gip - giant cell interstitial pneumonitis 61
giant cell lung carcinoma 8
carcinoma, giant cell 61
carcinoma giant cell 45
giant cell carcinoma 8


External Ids:

Disease Ontology8 DOID:5583
NCIt40 C3779
SNOMED-CT57 42596004, 254631008
MeSH35 D018286

Related Diseases for Lung Giant Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lung Giant Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1papillary carcinoma30.0KRT18, NME1, CDH1
2bladder carcinoma30.0CDKN2A, CDH1, KRT18
3pleomorphic carcinoma10.4
4neuroendocrine carcinoma10.2
5spindle cell carcinoma10.2
6acquired immunodeficiency syndrome10.2
7cystadenoma10.0
8pancreas sarcoma10.0
9lung combined large cell neuroendocrine carcinoma10.0
10hepatitis e10.0
11pseudomyxoma peritonei10.0
12lateral medullary syndrome10.0
13small cell carcinoma10.0
14follicular dendritic cell sarcoma10.0
15gynecomastia10.0
16n syndrome10.0
17large cell carcinoma10.0
18multicentric castleman disease10.0
19meningitis10.0IL8
20hodgkin's lymphoma10.0HDAC10
21inflammatory bowel disease10.0IL8
22skin melanoma10.0NME1
23neuroblastoma10.0NME1
24pneumonia10.0IL8
25severe combined immunodeficiency10.0IL2RG
26hepatitis c10.0KRT18
27pulmonary emphysema10.0TIMP2
28bronchiolitis10.0IL8
29gingivitis10.0TIMP1
30duodenal ulcer10.0IL8
31fibromatosis10.0TIMP2
32myeloid leukemia10.0NME1
33glaucoma10.0TIMP2
34hepatoblastoma10.0KRT18
35biliary atresia10.0TIMP1
36meningioma10.0PCNA
37arthropathy10.0TIMP1
38pituitary adenoma10.0PCNA
39pulmonary disease, chronic obstructive10.0TIMP1
40leiomyoma10.0PCNA
41oral submucous fibrosis10.0TIMP1
42chordoma10.0KRT18
43gingival overgrowth10.0TIMP1
44gastrointestinal stromal tumor10.0PCNA
45actinic keratosis10.0PCNA
46gastrointestinal system disease10.0CDH1
47psoriasis10.0KRT18, IL8
48colon adenocarcinoma10.0CDH1
49stomach cancer10.0CDH1
50viral hepatitis10.0KRT18

Graphical network of the top 20 diseases related to Lung Giant Cell Carcinoma:



Diseases related to lung giant cell carcinoma

Clinical Features for Lung Giant Cell Carcinoma

Drugs & Therapeutics for Lung Giant Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lung Giant Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Lung Giant Cell Carcinoma

Search NIH Clinical Center for Lung Giant Cell Carcinoma

Search CenterWatch for Lung Giant Cell Carcinoma

Genetic Tests for Lung Giant Cell Carcinoma

Anatomical Context for Lung Giant Cell Carcinoma

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Lung Giant Cell Carcinoma:

33
Lung, Thyroid

FMA organs/tissues related to Lung Giant Cell Carcinoma:

14
Large undifferentiated cells

Animal Models for Lung Giant Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Lung Giant Cell Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5NME1, IL2RG, CDH1, CDKN2A, TIMP1
2MP:00053977.6TIMP2, TIMP1, CDKN2A, PCNA, IL8, IL2RG
3MP:00107687.3CDKN2A, CDH1, PCNA, IL2RG, MMP2, NME1
4MP:00053877.2TIMP2, TIMP1, CDKN2A, CDH1, PCNA, IL8

Publications for Lung Giant Cell Carcinoma

Sources:
51PubMed
See all sources

Articles related to Lung Giant Cell Carcinoma:

(show all 22)
idTitleAuthorsYear
1
Combined large cell neuroendocrine carcinoma with giant cell carcinoma of the lungs: a case report. (23957954)
2013
2
Giant gingival pseudoepitheliomatous hyperplasia in lung squamous cell carcinoma. (22801162)
2012
3
Giant intracardiac neoplasic thrombus of a large cell neuroendocrine carcinoma of the lung. (19144545)
2010
4
Giant cell lung carcinoma in a man with acquired immunodeficiency syndrome. (18937080)
2009
5
Novel microdeletion in the transforming growth factor beta type II receptor gene is associated with giant and large cell variants of nonsmall cell lung carcinoma. (17117417)
2007
6
Interleukin-6-producing giant cell carcinoma of the lung with multicentric Castleman's disease-like presentation. (17527041)
2007
7
Gynecomastia attributable to human chorionic gonadotropin-secreting giant cell carcinoma of lung. (12917067)
2003
8
Study on differentially expressed molecules influencing the metastatic potential between highly and poorly metastatic human lung giant cell carcinoma]. (14690554)
2003
9
Pleomorphic (giant and/or spindle cell) carcinoma of lung shows a high percentage of variant CYP1A12. (11468695)
2001
10
Primary choriocarcinoma and human chorionic gonadotrophin-producing giant cell carcinoma of the lung: are they independent entities? (10632747)
2000
11
Study on the metastatic mechanisms of human giant-cell lung carcinoma comparison between the strains C and D. (10219898)
1998
12
Large cell carcinoma of lung with osteoclast-like giant cells. (9639130)
1998
13
Gynaecomastia in a patient with a hCG producing giant cell carcinoma of the lung. Case report. (7621102)
1995
14
Pleomorphic carcinoma (spindle and giant cell) of the lung. (7968314)
1994
15
Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line. (8017834)
1994
16
Signal transduction study on the growth regulation of cells from human giant cell lung carcinoma in vitro]. (8403096)
1993
17
Immunohistochemical features of giant cell carcinoma of the lung: patterns of expression of cytokeratins, vimentin, and the mucinous glycoprotein recognized by monoclonal antibody A-80. (1710080)
1991
18
Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes. (2200751)
1990
19
Joining of the c-myc gene and a line 1 family member on chromosome 8 in a human primary giant cell carcinoma of the lung. (2334929)
1990
20
Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells. (2659722)
1989
21
Bilateral diffuse malignant melanoma of the uvea associated with large cell carcinoma, giant cell type, of the lung. Case report of a newly described syndrome. (6096784)
1984
22
Subacute (giant cell) thyroiditis and giant cell myocarditis in patient with carcinoma of lung. (4760024)
1973

Genetic Variations for Lung Giant Cell Carcinoma

Expression for genes affiliated with Lung Giant Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lung Giant Cell Carcinoma

Search GEO for disease gene expression data for Lung Giant Cell Carcinoma.

Pathways for genes affiliated with Lung Giant Cell Carcinoma

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 4Cell Signaling Technology, 54Reactome, 12EMD Millipore
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Pathways related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL8
210.1MMP2
39.7IL8, CDKN2A
4
Hide members
9.5TIMP2, TIMP1, IL2RG
59.3TIMP2, TIMP1, MMP2
6
Hide members
9.3TIMP2, TIMP1, MMP2
79.3TIMP2, TIMP1, MMP2
8
Hide members
9.3MMP2, TIMP1, TIMP2
9
Hide members
9.0TIMP2, TIMP1, CDH1, IL2RG
10
Hide members
9.0PCNA, CDH1, CDKN2A
118.8CDKN2A, CDH1, IL8, MMP2
12
Cell adhesion ECM remodeling
Hide members
8.6MMP2, IL8, CDH1, TIMP1, TIMP2
13
Hide members
8.2MMP2, CDKN2A, HDAC10, TIMP1, TIMP2
14
Hide members
7.9TIMP2, TIMP1, CDKN2A, CDH1, IL8, IL2RG

Compounds for genes affiliated with Lung Giant Cell Carcinoma

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1(4-aminophenyl)mercuric acetate4510.5TIMP1
2matrigel4510.2CDH1, NME1
3etoposide45 50 60 1113.0TIMP1, CDH1
4pge24510.0CDH1, MMP2
5methyl selenol459.8TIMP2, TIMP1, MMP2
6latanoprost45 1110.7TIMP1, TIMP2, MMP2
7polycarbonate459.7CDH1, MMP2, IL8
8chi 2459.7NME1, CDH1, TIMP2
9s-allylcysteine459.6CDH1, PCNA
10norcantharidin459.6TIMP2, PCNA, MMP2
11hydroxamate459.5MMP2, TIMP1, TIMP2
12cyclosporin a45 29 6011.4IL2RG, PCNA, TIMP2
13aprotinin45 1110.4MMP2, TIMP1, TIMP2, IL8
14gamma-linolenic acid45 2410.4PCNA, TIMP1, CDH1
15alendronate45 50 1111.3TIMP2, TIMP1, MMP2
16aspartate459.3KRT18, NME1, CDH1, CDKN2A
17temozolomide45 1110.3CDKN2A, MMP2, PCNA
18go 697645 6010.2CDH1, MMP2, IL8
19p00001459.2CDKN2A, TIMP2, CDH1
20o6-methylguanine459.2PCNA, CDH1, CDKN2A
21p002459.1NME1, CDH1, KRT18, TIMP1, TIMP2
22paclitaxel45 50 1111.1CDH1, CDKN2A, TIMP1, TIMP2
23cytochalasin d45 6010.0IL8, CDH1, TIMP2, MMP2, TIMP1
24hematoxylin459.0CDKN2A, CDH1, PCNA, KRT18
25herbimycin a45 6010.0TIMP1, CDH1, TIMP2, MMP2, IL8
26hyaluronic acid45 2410.0MMP2, IL8, CDH1, TIMP1, TIMP2
27sb 20358045 609.9CDH1, TIMP1, IL8, MMP2, TIMP2
28crcs458.9CDKN2A, NME1, CDH1
29pd 98,059458.9TIMP1, IL8, MMP2, CDH1, TIMP2
30ly294002458.9MMP2, IL8, CDH1, TIMP1, TIMP2
31actinomycin d458.9TIMP1, KRT18, CDKN2A, IL8, TIMP2
32mg 13245 609.8KRT18, IL8, PCNA, CDH1, CDKN2A
33serine458.7TIMP2, TIMP1, CDH1, IL8, MMP2, NME1
345-aza-2deoxycytidine458.6CDKN2A, PCNA, CDH1, TIMP1, TIMP2
35creatinine458.5CDKN2A, CDH1, MMP2, NME1, KRT18, TIMP2
36nitric oxide45 11 2410.5IL8, CDKN2A, TIMP2, TIMP1, NME1, KRT18
37dexamethasone45 50 29 1111.4PCNA, NME1, CDH1, CDKN2A, TIMP1, KRT18
38h2o2458.3MMP2, IL8, PCNA, TIMP2, CDKN2A, TIMP1
39azathioprine45 50 2 1111.3MMP2, PCNA, CDH1, TIMP2, TIMP1, CDKN2A
40methotrexate45 50 1110.3PCNA, CDH1, MMP2, CDKN2A, TIMP1, TIMP2
415fluorouracil458.0CDH1, TIMP2, CDKN2A, PCNA, MMP2, NME1
42n acetylcysteine458.0IL8, PCNA, CDH1, CDKN2A, TIMP1, KRT18
43genistein45 29 60 2 11 2413.0PCNA, TIMP2, TIMP1, CDKN2A, CDH1, MMP2
44lactate457.9TIMP2, TIMP1, IL8, MMP2, NME1, KRT18
45cysteine457.7MMP2, PCNA, IL8, TIMP2, TIMP1, CDKN2A
46paraffin457.7NME1, MMP2, PCNA, CDH1, CDKN2A, TIMP1
47progesterone45 60 29 11 2411.7PCNA, CDH1, KRT18, NME1, MMP2, CDKN2A
48alanine457.7TIMP1, CDH1, KRT18, PCNA, MMP2, NME1
49retinoic acid45 248.6TIMP2, TIMP1, CDKN2A, PCNA, MMP2, NME1
50vegf457.4MMP2, IL8, PCNA, CDH1, CDKN2A, NME1

GO Terms for genes affiliated with Lung Giant Cell Carcinoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:0226179.0MMP2, TIMP1, TIMP2
2negative regulation of cell proliferationGO:0082859.0NME1, IL8, CDKN2A, TIMP2

Molecular functions related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:0081919.8TIMP1, TIMP2
2protein bindingGO:0055156.1KRT18, TIMP1, HDAC10, CDKN2A, CDH1, PCNA

Products for genes affiliated with Lung Giant Cell Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lung Giant Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet