MCID: LNG017
MIFTS: 47

Lung Giant Cell Carcinoma malady

Cancer diseases, Respiratory diseases categories
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Summaries for Lung Giant Cell Carcinoma

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Giant cell carcinoma of the lung (GCCL) is a rare histological form of large-cell lung carcinoma, a... more...

MalaCards: Lung Giant Cell Carcinoma, also known as giant cell carcinoma of lung, is related to neuroendocrine carcinoma and hepatitis. An important gene associated with Lung Giant Cell Carcinoma is IL8 (interleukin 8), and among its related pathways are E-cadherin signaling in the nascent adherens junction and Arf6 trafficking events. The compounds chi 2 and methyl selenol have been mentioned in the context of this disorder. Affiliated tissues include large undifferentiated cells and lung, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Disease Ontology:8 A lung carcinoma that is located in large undifferentiated cells.

Aliases & Classifications for Lung Giant Cell Carcinoma

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8Disease Ontology, 62UMLS, 40NCIt, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

lung giant cell carcinoma 8
giant cell carcinoma of lung 8 62
gip - giant cell interstitial pneumonitis 62
giant cell lung carcinoma 8
carcinoma, giant cell 62
giant cell carcinoma 8


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Disease Ontology8 DOID:5583
NCIt40 C3779
SNOMED-CT58 254631008, 42596004
MeSH35 D018286

Related Diseases for Lung Giant Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Lung Giant Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma30.2KRT18, CDH1
2hepatitis30.1TIMP2, KRT18
3choriocarcinoma30.0TIMP2, TIMP1, MMP2, KRT18
4acquired immunodeficiency syndrome10.2
5fibromatosis10.1TIMP2
6pulpitis10.1TIMP1
7actinic keratosis10.1PCNA
8alcoholic hepatitis10.1KRT18, IL8
9arthropathy10.1TIMP1
10bronchopulmonary dysplasia10.1TIMP1, IL8
11arthritis10.1TIMP1, IL8
12monocytic leukemia10.1IL8
13oxyphilic adenoma10.1NME1, KRT18
14keratoacanthoma10.1PCNA, NME1
15cystadenoma10.1
16large cell neuroendocrine carcinoma10.1
17follicular dendritic cell sarcoma10.1
18gynecomastia10.1
19pseudomyxoma peritonei10.1
20small cell carcinoma10.1
21dendritic cell sarcoma10.1
22esophagitis10.1
23giant cell tumor10.1
24prostatitis10.1
25respiratory failure10.1
26sarcoma10.1
27thyroiditis10.1
28castleman's disease10.1
29leukoplakia10.1NME1, PCNA
30smooth muscle tumor10.1PCNA, NME1
31proliferative vitreoretinopathy10.1TIMP2, TIMP1
32gestational trophoblastic neoplasm10.1NME1, PCNA
33kidney cancer10.1CDH1
34bronchiolo-alveolar adenocarcinoma10.1CDH1, TIMP2
35myelofibrosis10.1TIMP2, TIMP1
36pleomorphic adenoma10.1PCNA, KRT18
37laryngeal benign neoplasm10.1PCNA, NME1
38tongue squamous cell carcinoma10.0CDH1, NME1
39cervical adenocarcinoma10.0NME1, CDKN2A
40renal fibrosis10.0TIMP1, CDH1
41cervical intraepithelial neoplasia10.0NME1, CDKN2A
42follicular adenoma10.0NME1, CDH1
43cervical squamous cell carcinoma10.0TIMP2, CDKN2A
44idiopathic pulmonary fibrosis10.0KRT18, IL8, TIMP1
45proliferative diabetic retinopathy10.0IL8, TIMP1, TIMP2
46periodontitis10.0TIMP2, TIMP1, IL8
47synovitis10.0TIMP2, TIMP1, IL8
48adenoid cystic carcinoma10.0PCNA, CDH1
49nasopharynx carcinoma10.0CDH1, CDKN2A
50gastritis10.0KRT18, PCNA, IL8

Graphical network of the top 20 diseases related to Lung Giant Cell Carcinoma:



Diseases related to lung giant cell carcinoma

Symptoms for Lung Giant Cell Carcinoma

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Drugs & Therapeutics for Lung Giant Cell Carcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Lung Giant Cell Carcinoma

Search NIH Clinical Center for Lung Giant Cell Carcinoma

Genetic Tests for Lung Giant Cell Carcinoma

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Anatomical Context for Lung Giant Cell Carcinoma

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Lung Giant Cell Carcinoma:

33
Lung

FMA organs/tissues related to Lung Giant Cell Carcinoma:

14
Large undifferentiated cells

Animal Models for Lung Giant Cell Carcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Lung Giant Cell Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.8TIMP1, MMP2, NME1, CDKN2A, CDH1
2MP:00053797.7TIMP1, PCNA, NME1, CDKN2A, CDH1
3MP:00053767.3CDH1, CDKN2A, NME1, MMP2, TIMP1, TIMP2
4MP:00053977.1CDKN2A, TIMP2, TIMP1, MMP2, IL8, PCNA
5MP:00053876.9TIMP2, TIMP1, MMP2, IL8, PCNA, CDKN2A
6MP:00053786.8TIMP1, MMP2, PCNA, NME1, KRT18, CDKN2A
7MP:00107686.7TIMP1, MMP2, PCNA, NME1, KRT18, CDKN2A

Publications for Lung Giant Cell Carcinoma

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52PubMed
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Articles related to Lung Giant Cell Carcinoma:

idTitleAuthorsYear
1
Study on differentially expressed molecules influencing the metastatic potential between highly and poorly metastatic human lung giant cell carcinoma]. (14690554)
2003
2
Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line. (8017834)
1994
3
Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes. (2200751)
1990
4
Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells. (2659722)
1989

Variations for Lung Giant Cell Carcinoma

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Expression for genes affiliated with Lung Giant Cell Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Giant Cell Carcinoma

Search GEO for disease gene expression data for Lung Giant Cell Carcinoma.

Pathways for genes affiliated with Lung Giant Cell Carcinoma

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Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 30KEGG, 53QIAGEN, 55Reactome, 5Cell Signaling Technology, 12EMD Millipore
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Pathways related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CDH1, NME1
29.6NME1, CDH1
39.3IL8, MMP2
49.3IL8, MMP2
59.3IL8, MMP2
69.3IL8, MMP2
79.0CDKN2A, MMP2
89.0CDKN2A, PCNA, IL8
98.8CDH1, IL8, MMP2
10
Show member pathways
Cell cycle38
8.8CDH1, CDKN2A, PCNA
11
Show member pathways
8.8MMP2, TIMP1, TIMP2
128.8TIMP2, TIMP1, MMP2
138.8TIMP2, TIMP1, MMP2
14
Show member pathways
8.8TIMP2, TIMP1, IL8, CDH1
15
Show member pathways
8.8TIMP2, TIMP1, IL8, CDH1
16
Show member pathways
8.3TIMP2, TIMP1, MMP2, CDH1
17
Show member pathways
Signaling Pathways in Glioblastoma38
8.2CDH1, CDKN2A, IL8, MMP2
188.2MMP2, IL8, CDKN2A, CDH1
19
Show member pathways
8.2TIMP2, TIMP1, MMP2, CDKN2A
20
Show member pathways
8.2CDKN2A, MMP2, TIMP1, TIMP2
21
Show member pathways
7.9CDH1, IL8, MMP2, TIMP1, TIMP2
22
Show member pathways
7.8TIMP2, TIMP1, IL8, KRT18, CDKN2A, CDH1

Compounds for genes affiliated with Lung Giant Cell Carcinoma

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 61Tocris Bioscience, 51PharmGKB, 29IUPHAR, 3BitterDB
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Compounds related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1chi 2459.3TIMP2, NME1, CDH1
2methyl selenol459.2TIMP2, MMP2, TIMP1
3latanoprost45 1110.1TIMP2, TIMP1, MMP2
4gamma-linolenic acid45 2410.1PCNA, CDH1, TIMP1
5(4-aminophenyl)mercuric acetate459.0TIMP2, TIMP1, MMP2
6norcantharidin459.0TIMP2, MMP2, PCNA
7polycarbonate459.0IL8, CDH1, MMP2
8o6-methylguanine458.8PCNA, CDH1, CDKN2A
9p002458.8TIMP2, TIMP1, NME1, CDH1, KRT18
10hematoxylin458.8CDH1, CDKN2A, PCNA, KRT18
11aprotinin45 119.8MMP2, TIMP1, IL8, TIMP2
12doxycycline45 119.5KRT18, CDKN2A, TIMP1, MMP2
13temozolomide45 119.5MMP2, PCNA, CDKN2A
14mg 13245 619.5PCNA, CDKN2A, KRT18, CDH1, IL8
15actinomycin d458.5TIMP2, IL8, KRT18, TIMP1, CDKN2A
16hydroxamate458.5TIMP2, TIMP1, MMP2
17cytochalasin d45 619.3IL8, TIMP1, CDH1, TIMP2, MMP2
18herbimycin a45 619.3MMP2, TIMP1, TIMP2, CDH1, IL8
19hyaluronic acid45 249.3TIMP2, TIMP1, CDH1, IL8, MMP2
205-aza-2deoxycytidine458.3TIMP2, PCNA, CDKN2A, TIMP1, CDH1
21sb 20358045 619.3TIMP1, CDH1, IL8, TIMP2, MMP2
22paclitaxel45 51 1110.2CDH1, CDKN2A, PCNA, TIMP1, TIMP2
23nitric oxide45 24 1110.2NME1, IL8, KRT18, TIMP2, TIMP1, CDKN2A
24pd 98,059458.2MMP2, TIMP2, TIMP1, IL8, CDH1
25ly294002458.2CDH1, TIMP2, MMP2, TIMP1, IL8
26heparin45 29 24 1111.1IL8, PCNA, TIMP2, CDH1, TIMP1
27etoposide45 51 61 1111.1TIMP1, MMP2, PCNA, NME1, CDH1
28cisplatin45 51 61 1111.1NME1, PCNA, TIMP1, CDH1, CDKN2A
29pge2458.0TIMP2, CDH1, NME1, IL8, MMP2, TIMP1
30dexamethasone45 51 29 1110.7KRT18, NME1, IL8, TIMP1, CDKN2A, CDH1
31butyrate457.7CDH1, PCNA, TIMP2, TIMP1, IL8, KRT18
32h2o2457.7IL8, TIMP1, PCNA, MMP2, TIMP2, CDKN2A
33matrigel457.7MMP2, CDH1, TIMP2, TIMP1, IL8, NME1
34azathioprine45 3 51 1110.6PCNA, CDH1, TIMP2, CDKN2A, MMP2, TIMP1
35methotrexate51 45 119.5CDKN2A, PCNA, MMP2, TIMP2, CDH1, TIMP1
365fluorouracil457.3TIMP2, KRT18, CDH1, MMP2, PCNA, NME1
37n acetylcysteine457.3IL8, CDKN2A, KRT18, CDH1, TIMP1, MMP2
38creatinine457.3MMP2, PCNA, NME1, KRT18, CDKN2A, CDH1
39genistein45 29 61 3 24 1112.2CDH1, TIMP1, CDKN2A, PCNA, IL8, MMP2
40aspartate457.2CDKN2A, KRT18, NME1, PCNA, MMP2, CDH1
41lactate457.1MMP2, CDH1, KRT18, NME1, TIMP2, TIMP1
42serine457.0IL8, TIMP2, MMP2, CDH1, NME1, KRT18
43egcg456.9IL8, PCNA, MMP2, TIMP1, TIMP2, CDKN2A
44cysteine456.9CDKN2A, PCNA, IL8, TIMP1, NME1, MMP2
45paraffin456.8MMP2, CDH1, CDKN2A, KRT18, NME1, PCNA
46progesterone45 29 61 24 1110.8NME1, CDH1, CDKN2A, KRT18, PCNA, MMP2
47alanine456.8CDKN2A, KRT18, NME1, PCNA, MMP2, TIMP1
48estrogen456.8KRT18, NME1, TIMP1, TIMP2, PCNA, CDKN2A
49retinoic acid45 247.8CDKN2A, KRT18, NME1, PCNA, TIMP2, CDH1
50vegf456.5MMP2, IL8, TIMP1, PCNA, NME1, KRT18

GO Terms for genes affiliated with Lung Giant Cell Carcinoma

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16Gene Ontology
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Cellular components related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9CDH1, IL8, MMP2, TIMP1, TIMP2

Biological processes related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to cytokineGO:0340979.6TIMP1, TIMP2
2cellular response to amino acid stimulusGO:0712308.8CDH1, MMP2
3negative regulation of cell proliferationGO:0082858.7TIMP2, IL8, NME1, CDKN2A
4extracellular matrix disassemblyGO:0226178.3CDH1, MMP2, TIMP1, TIMP2
5extracellular matrix organizationGO:0301988.3TIMP2, TIMP1, MMP2, CDH1

Molecular functions related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:0081919.6TIMP1, TIMP2
2protein bindingGO:0055155.8CDH1, TIMP2, TIMP1, MMP2, IL8, PCNA

Products for genes affiliated with Lung Giant Cell Carcinoma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Lung Giant Cell Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet