MCID: LNG017
MIFTS: 39

Lung Giant Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Lung Giant Cell Carcinoma

MalaCards integrated aliases for Lung Giant Cell Carcinoma:

Name: Lung Giant Cell Carcinoma 12 14
Carcinoma, Giant Cell 41 69
Giant Cell Carcinoma of Lung 69
Giant Cell Lung Carcinoma 12
Giant Cell Carcinoma 12
Carcinoma Giant Cell 51

Classifications:



External Ids:

Disease Ontology 12 DOID:5583
MeSH 41 D018286
NCIt 46 C3779 C4452
SNOMED-CT 64 254631008 42596004

Summaries for Lung Giant Cell Carcinoma

Disease Ontology : 12 A lung carcinoma that is located in large undifferentiated cells.

MalaCards based summary : Lung Giant Cell Carcinoma, also known as carcinoma, giant cell, is related to renal cell carcinoma, nonpapillary and pleural tuberculosis, and has symptoms including hemoptysis, fever and dyspnea. An important gene associated with Lung Giant Cell Carcinoma is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include large undifferentiated cells and lung, and related phenotypes are growth/size/body region and mortality/aging

Related Diseases for Lung Giant Cell Carcinoma

Diseases related to Lung Giant Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 renal cell carcinoma, nonpapillary 28.5 CDH1 MMP2 MMP9 NME1
2 pleural tuberculosis 10.3 CXCL8 TIMP1
3 lymphoma, large-cell, immunoblastic 10.3 MYC TIMP1
4 crohn's colitis 10.3 CDH1 CXCL8
5 bronchopulmonary dysplasia 10.3 CXCL8 TIMP1
6 hypopharynx cancer 10.2 CDH1 NME1
7 conjunctivochalasis 10.2 MMP2 TIMP1
8 lymphoepithelioma-like carcinoma 10.2 CDH1 KRT18
9 vibratory urticaria 10.2 CXCL8 MMP9
10 hypertrophic scars 10.2 MMP2 TIMP1
11 squamous cell carcinoma of the hypopharynx 10.2 MMP9 TIMP1
12 septic arthritis 10.2 CXCL8 MMP2
13 papillary adenocarcinoma 10.2 CDH1 NME1
14 periodontosis 10.1 CXCL8 MMP9
15 mycetoma 10.1 CXCL8 MMP9
16 tuberculous meningitis 10.1 CXCL8 MMP9
17 extracranial arteriovenous malformation 10.1 MMP2 MMP9
18 focal myositis 10.1 MMP2 MMP9
19 spastic entropion 10.1 MMP2 MMP9
20 lentigo maligna melanoma 10.1 MMP2 MMP9
21 villous adenocarcinoma 10.1 MMP2 MMP9
22 psammomatous meningioma 10.1 MMP2 MMP9
23 interstitial cystitis 10.1 CDH1 CXCL8
24 senile ectropion 10.1 MMP2 MMP9
25 internal hemorrhoid 10.0 MMP2 MMP9
26 central nervous system tuberculosis 10.0 MMP9 TIMP1
27 parotitis 10.0 MMP2 MMP9
28 light chain deposition disease 10.0 MMP2 MMP9
29 opisthorchiasis 10.0 CXCL8 IL6R
30 ovarian lymphoma 10.0 CXCL8 KRT18 MYC
31 klatskin's tumor 10.0 MMP2 MMP9
32 adenomyosis 10.0 MMP2 MMP9
33 hypercementosis 10.0 MMP2 MMP9
34 cryptogenic organizing pneumonia 10.0 CXCL8 MMP9 TIMP1
35 corneal ulcer 10.0 MMP2 MMP9
36 preterm premature rupture of the membranes 10.0 CXCL8 IL6R
37 appendicitis 10.0 CXCL8 MMP9 TIMP1
38 bronchiolitis obliterans 10.0 CXCL8 MMP9 TIMP1
39 odontogenic myxoma 10.0 MMP2 MMP9
40 oral submucous fibrosis 10.0 CDH1 MMP2 TIMP1
41 interstitial lung disease 10.0 CXCL8 MMP9 TIMP1
42 malignant ovarian surface epithelial-stromal neoplasm 9.9 CDH1 MMP2 NME1
43 ovary epithelial cancer 9.9 CDH1 MMP2 NME1
44 joint disorders 9.9 IL6R TIMP1
45 pelvic organ prolapse 9.9 MMP2 MMP9
46 gallbladder cancer 9.9 CDH1 MMP2 NME1
47 gastric adenocarcinoma 9.9 CDH1 MYC NME1
48 hypertensive heart disease 9.9 MMP2 MMP9
49 acute transverse myelitis 9.9 CXCL8 MMP2 MMP9
50 pharynx cancer 9.9 CDH1 MMP9

Graphical network of the top 20 diseases related to Lung Giant Cell Carcinoma:



Diseases related to Lung Giant Cell Carcinoma

Symptoms & Phenotypes for Lung Giant Cell Carcinoma

UMLS symptoms related to Lung Giant Cell Carcinoma:


hemoptysis, fever, dyspnea, coughing

MGI Mouse Phenotypes related to Lung Giant Cell Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.76 CDH1 IL6R KRT18 MMP2 MMP9 MYC
2 mortality/aging MP:0010768 9.56 CDH1 IL6R KRT18 MMP2 MMP9 MYC
3 neoplasm MP:0002006 9.17 CDH1 IL6R MMP2 MMP9 MYC NME1

Drugs & Therapeutics for Lung Giant Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Lung Giant Cell Carcinoma

Cochrane evidence based reviews: carcinoma, giant cell

Genetic Tests for Lung Giant Cell Carcinoma

Anatomical Context for Lung Giant Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Lung Giant Cell Carcinoma:

18
Large Undifferentiated Cells

MalaCards organs/tissues related to Lung Giant Cell Carcinoma:

38
Lung

Publications for Lung Giant Cell Carcinoma

Articles related to Lung Giant Cell Carcinoma:

# Title Authors Year
1
Epidemiological features of lung giant cell carcinoma and therapy for patients with EGFR mutations based on case reports and the surveillance, epidemiology, and end results (SEER) database. ( 28445978 )
2017
2
Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma. ( 28159994 )
2017
3
[Study on differentially expressed molecules influencing the metastatic potential between highly and poorly metastatic human lung giant cell carcinoma]. ( 14690554 )
2003
4
Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line. ( 8017834 )
1994
5
Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes. ( 2200751 )
1990
6
Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells. ( 2659722 )
1989

Variations for Lung Giant Cell Carcinoma

Cosmic variations for Lung Giant Cell Carcinoma:

9 (show top 50) (show all 80)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM905 RB1 lung,NS,carcinoma,giant cell carcinoma c.245C>A p.S82* 17
2 COSM516 KRAS lung,NS,carcinoma,giant cell carcinoma c.34G>T p.G12C 17
3 COSM6224 EGFR lung,NS,carcinoma,giant cell carcinoma c.2573T>G p.L858R 17
4 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 13
5 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 13
6 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 13
7 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 13
8 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 13
9 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 13
10 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 13
11 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 13
12 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 13
13 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 13
14 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 13
15 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 13
16 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 13
17 COSM43750 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 13
18 COSM43753 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 13
19 COSM95367 TLR5 lung,NS,carcinoma,undifferentiated carcinoma c.1A>G p.M1V 13
20 COSM95359 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 13
21 COSM95356 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 13
22 COSM95347 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 13
23 COSM95342 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 13
24 COSM95340 TLE4 lung,NS,carcinoma,undifferentiated carcinoma c.859A>C p.K287Q 13
25 COSM95334 TIAM1 lung,NS,carcinoma,undifferentiated carcinoma c.3718G>C p.E1240Q 13
26 COSM95292 STK38 lung,NS,carcinoma,undifferentiated carcinoma c.407C>G p.A136G 13
27 COSM95282 STAT1 lung,NS,carcinoma,undifferentiated carcinoma c.2042A>T p.Y681F 13
28 COSM95276 SPRY2 lung,NS,carcinoma,undifferentiated carcinoma c.652T>C p.C218R 13
29 COSM95270 SPOP lung,NS,carcinoma,undifferentiated carcinoma c.570A>C p.L190F 13
30 COSM94327 RNF145 lung,NS,carcinoma,undifferentiated carcinoma c.647G>A p.G216E 13
31 COSM95658 RIN1 lung,NS,carcinoma,undifferentiated carcinoma c.1210C>T p.Q404* 13
32 COSM95187 RICTOR lung,NS,carcinoma,undifferentiated carcinoma c.1711C>A p.H571N 13
33 COSM96136 PLCG1 lung,NS,carcinoma,undifferentiated carcinoma c.3366C>T p.D1122D 13
34 COSM95013 PKHD1 lung,NS,carcinoma,undifferentiated carcinoma c.2753C>A p.P918Q 13
35 COSM94967 PIK3C2A lung,NS,carcinoma,undifferentiated carcinoma c.3240A>T p.E1080D 13
36 COSM94958 PDIA4 lung,NS,carcinoma,undifferentiated carcinoma c.1735G>T p.V579F 13
37 COSM96110 PAX6 lung,NS,carcinoma,undifferentiated carcinoma c.372G>T p.G124G 13
38 COSM94918 PARP1 lung,NS,carcinoma,undifferentiated carcinoma c.790C>G p.L264V 13
39 COSM94897 P2RY1 lung,NS,carcinoma,undifferentiated carcinoma c.238A>G p.M80V 13
40 COSM94878 NTSR1 lung,NS,carcinoma,undifferentiated carcinoma c.808G>T p.A270S 13
41 COSM94867 NRG3 lung,NS,carcinoma,undifferentiated carcinoma c.490G>T p.A164S 13
42 COSM94848 NOTCH2 lung,NS,carcinoma,undifferentiated carcinoma c.5637G>A p.M1879I 13
43 COSM95032 MED1 lung,NS,carcinoma,undifferentiated carcinoma c.2444A>G p.H815R 13
44 COSM94685 MC5R lung,NS,carcinoma,undifferentiated carcinoma c.458T>C p.I153T 13
45 COSM94681 MAX lung,NS,carcinoma,undifferentiated carcinoma c.368A>G p.Y123C 13
46 COSM94657 MAML1 lung,NS,carcinoma,undifferentiated carcinoma c.2605C>A p.Q869K 13
47 COSM94614 LMTK2 lung,NS,carcinoma,undifferentiated carcinoma c.2931C>A p.S977R 13
48 COSM95625 LHCGR lung,NS,carcinoma,undifferentiated carcinoma c.1660C>T p.R554* 13
49 COSM520 KRAS lung,NS,carcinoma,undifferentiated carcinoma c.35G>T p.G12V 13
50 COSM95622 KIF27 lung,NS,carcinoma,undifferentiated carcinoma c.620C>G p.S207* 13

Expression for Lung Giant Cell Carcinoma

Search GEO for disease gene expression data for Lung Giant Cell Carcinoma.

Pathways for Lung Giant Cell Carcinoma

Pathways related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CDH1 CXCL8 IL6R MMP2 MMP9 MYC
2
Show member pathways
13.58 CDH1 CXCL8 IL6R KRT18 MYC TIMP1
3
Show member pathways
13.1 CXCL8 IL6R MMP2 MMP9 MYC TIMP1
4
Show member pathways
12.84 CDH1 IL6R MMP9 MYC
5 12.6 CDH1 CXCL8 IL6R MMP2 MMP9 MYC
6
Show member pathways
12.55 CDH1 MMP2 MMP9 TIMP1
7
Show member pathways
12.14 CXCL8 IL6R MMP9
8 12.11 MMP2 MMP9 MYC
9 12.05 CXCL8 MMP9 MYC
10 11.87 CDH1 IL6R MMP2 MMP9 MYC
11 11.84 CDH1 MMP2 MMP9
12 11.83 CXCL8 MMP9 MYC
13
Show member pathways
11.73 MMP2 MMP9 TIMP1
14 11.67 MMP2 MMP9 TIMP1
15
Show member pathways
11.65 IL6R MYC TIMP1
16 11.61 MMP9 MYC NME1
17 11.48 CXCL8 MMP2 MMP9
18 11.47 CXCL8 MMP2 MMP9 TIMP1
19
Show member pathways
11.45 CXCL8 MMP2 MMP9
20 11.45 CDH1 CXCL8 MMP2 MMP9 MYC
21
Show member pathways
11.43 MMP2 MMP9 MYC
22 11.41 CXCL8 MMP2 MMP9 TIMP1
23 11.35 MMP2 MMP9
24 11.34 CDH1 MMP9
25 11.34 CXCL8 IL6R MYC
26
Show member pathways
11.32 MMP2 MMP9
27 11.31 CDH1 NME1
28 11.22 MMP2 MYC
29 11.22 CDH1 CXCL8 MMP2 MMP9 MYC
30 11.17 CDH1 NME1
31 11.16 CXCL8 MMP2
32 11.16 CXCL8 IL6R MMP2 MMP9 MYC TIMP1
33 11.14 MMP2 MMP9
34 11.14 CXCL8 MMP2 MMP9
35 11.03 MMP2 MMP9
36 11.01 MMP9 TIMP1
37 10.96 MMP2 MMP9

GO Terms for Lung Giant Cell Carcinoma

Cellular components related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 CDH1 CXCL8 IL6R MMP2 MMP9 TIMP1

Biological processes related to Lung Giant Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.46 KRT18 MMP9 MYC TIMP1
2 extrinsic apoptotic signaling pathway GO:0097191 9.43 IL6R KRT18
3 embryo implantation GO:0007566 9.4 MMP2 MMP9
4 cellular response to fibroblast growth factor stimulus GO:0044344 9.37 CXCL8 MYC
5 endodermal cell differentiation GO:0035987 9.32 MMP2 MMP9
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.26 MMP2 MMP9
7 positive regulation of DNA binding GO:0043388 9.13 MMP9 MYC NME1
8 extracellular matrix disassembly GO:0022617 8.92 CDH1 MMP2 MMP9 TIMP1

Sources for Lung Giant Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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