MCID: LNG017
MIFTS: 47

Lung Giant Cell Carcinoma malady

Respiratory diseases, Cancer diseases categories

Summaries for Lung Giant Cell Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Giant cell carcinoma of the lung (GCCL) is a rare histological form of large-cell lung carcinoma, a... more...

MalaCards: Lung Giant Cell Carcinoma, also known as giant cell carcinoma of lung, is related to papillary carcinoma and choriocarcinoma. An important gene associated with Lung Giant Cell Carcinoma is IL8 (interleukin 8), and among its related pathways are Glioma and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. The compounds (4-aminophenyl)mercuric acetate and matrigel have been mentioned in the context of this disorder. Affiliated tissues include large undifferentiated cells, lung and thyroid, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:8 A lung carcinoma that is located in large undifferentiated cells.

Aliases & Classifications for Lung Giant Cell Carcinoma

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8Disease Ontology, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

lung giant cell carcinoma 8
giant cell carcinoma of lung 8 60
gip - giant cell interstitial pneumonitis 60
giant cell lung carcinoma 8
carcinoma, giant cell 60
giant cell carcinoma 8


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Disease Ontology8 DOID:5583
NCIt39 C3779
SNOMED-CT56 42596004, 254631008
MeSH34 D018286

Related Diseases for Lung Giant Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Lung Giant Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1papillary carcinoma30.0KRT18, NME1, CDH1
2choriocarcinoma30.0TIMP2, TIMP1, MMP2, KRT18
3bladder carcinoma30.0CDKN2A, CDH1, KRT18
4melanoma29.9TIMP2, TIMP1, CDKN2A, CDH1, PCNA, IL8
5pleomorphic carcinoma10.4
6neuroendocrine carcinoma10.2
7spindle cell carcinoma10.2
8giant cell tumor10.2
9acquired immunodeficiency syndrome10.2
10cystadenoma10.0
11pancreas sarcoma10.0
12lung combined large cell neuroendocrine carcinoma10.0
13pseudomyxoma peritonei10.0
14lateral medullary syndrome10.0
15small cell carcinoma10.0
16follicular dendritic cell sarcoma10.0
17gynecomastia10.0
18large cell carcinoma10.0
19hepatitis a10.0
20dendritic cell sarcoma10.0
21esophagitis10.0
22follicular thyroid carcinoma10.0
23hepatitis10.0
24lung large cell carcinoma10.0
25papillary thyroid carcinoma10.0
26prostatitis10.0
27respiratory failure10.0
28sarcoma10.0
29thyroiditis10.0
30meningitis10.0IL8
31hodgkin's lymphoma10.0HDAC10
32inflammatory bowel disease10.0IL8
33skin melanoma10.0NME1
34neuroblastoma10.0NME1
35pneumonia10.0IL8
36severe combined immunodeficiency10.0IL2RG
37hepatitis c10.0KRT18
38pulmonary emphysema10.0TIMP2
39bronchiolitis10.0IL8
40gingivitis10.0TIMP1
41duodenal ulcer10.0IL8
42fibromatosis10.0TIMP2
43myeloid leukemia10.0NME1
44glaucoma10.0TIMP2
45hepatoblastoma10.0KRT18
46biliary atresia10.0TIMP1
47meningioma10.0PCNA
48arthropathy10.0TIMP1
49pituitary adenoma10.0PCNA
50pulmonary disease, chronic obstructive10.0TIMP1

Graphical network of the top 20 diseases related to Lung Giant Cell Carcinoma:



Diseases related to lung giant cell carcinoma

Clinical Features for Lung Giant Cell Carcinoma

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Drugs & Therapeutics for Lung Giant Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Lung Giant Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Lung Giant Cell Carcinoma

Search NIH Clinical Center for Lung Giant Cell Carcinoma

Search CenterWatch for Lung Giant Cell Carcinoma

Genetic Tests for Lung Giant Cell Carcinoma

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Anatomical Context for Lung Giant Cell Carcinoma

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Lung Giant Cell Carcinoma:

32
Lung, Thyroid

FMA organs/tissues related to Lung Giant Cell Carcinoma:

14
Large undifferentiated cells

Animal Models for Lung Giant Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lung Giant Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5NME1, IL2RG, CDH1, CDKN2A, TIMP1
2MP:00053977.6TIMP2, TIMP1, CDKN2A, PCNA, IL8, IL2RG
3MP:00107687.3CDKN2A, CDH1, PCNA, IL2RG, MMP2, NME1
4MP:00053877.2TIMP2, TIMP1, CDKN2A, CDH1, PCNA, IL8

Publications for Lung Giant Cell Carcinoma

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50PubMed
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Articles related to Lung Giant Cell Carcinoma:

(show all 22)
idTitleAuthorsYear
1
Combined large cell neuroendocrine carcinoma with giant cell carcinoma of the lungs: a case report. (23957954)
2013
2
Giant gingival pseudoepitheliomatous hyperplasia in lung squamous cell carcinoma. (22801162)
2012
3
Giant intracardiac neoplasic thrombus of a large cell neuroendocrine carcinoma of the lung. (19144545)
2010
4
Giant cell lung carcinoma in a man with acquired immunodeficiency syndrome. (18937080)
2009
5
Novel microdeletion in the transforming growth factor beta type II receptor gene is associated with giant and large cell variants of nonsmall cell lung carcinoma. (17117417)
2007
6
Interleukin-6-producing giant cell carcinoma of the lung with multicentric Castleman's disease-like presentation. (17527041)
2007
7
Gynecomastia attributable to human chorionic gonadotropin-secreting giant cell carcinoma of lung. (12917067)
2003
8
Study on differentially expressed molecules influencing the metastatic potential between highly and poorly metastatic human lung giant cell carcinoma]. (14690554)
2003
9
Pleomorphic (giant and/or spindle cell) carcinoma of lung shows a high percentage of variant CYP1A12. (11468695)
2001
10
Primary choriocarcinoma and human chorionic gonadotrophin-producing giant cell carcinoma of the lung: are they independent entities? (10632747)
2000
11
Study on the metastatic mechanisms of human giant-cell lung carcinoma comparison between the strains C and D. (10219898)
1998
12
Large cell carcinoma of lung with osteoclast-like giant cells. (9639130)
1998
13
Gynaecomastia in a patient with a hCG producing giant cell carcinoma of the lung. Case report. (7621102)
1995
14
Pleomorphic carcinoma (spindle and giant cell) of the lung. (7968314)
1994
15
Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line. (8017834)
1994
16
Signal transduction study on the growth regulation of cells from human giant cell lung carcinoma in vitro]. (8403096)
1993
17
Immunohistochemical features of giant cell carcinoma of the lung: patterns of expression of cytokeratins, vimentin, and the mucinous glycoprotein recognized by monoclonal antibody A-80. (1710080)
1991
18
Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes. (2200751)
1990
19
Joining of the c-myc gene and a line 1 family member on chromosome 8 in a human primary giant cell carcinoma of the lung. (2334929)
1990
20
Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells. (2659722)
1989
21
Bilateral diffuse malignant melanoma of the uvea associated with large cell carcinoma, giant cell type, of the lung. Case report of a newly described syndrome. (6096784)
1984
22
Subacute (giant cell) thyroiditis and giant cell myocarditis in patient with carcinoma of lung. (4760024)
1973

Genetic Variations for Lung Giant Cell Carcinoma

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Expression for genes affiliated with Lung Giant Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Giant Cell Carcinoma

Search GEO for disease gene expression data for Lung Giant Cell Carcinoma.

Pathways for genes affiliated with Lung Giant Cell Carcinoma

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology, 53Reactome, 12EMD Millipore
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Pathways related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL8
210.1MMP2
39.7IL8, CDKN2A
4
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9.5TIMP2, TIMP1, IL2RG
59.3TIMP2, TIMP1, MMP2
6
Hide members
9.3TIMP2, TIMP1, MMP2
79.3TIMP2, TIMP1, MMP2
8
Hide members
9.3MMP2, TIMP1, TIMP2
9
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9.0TIMP2, TIMP1, CDH1, IL2RG
10
Hide members
9.0PCNA, CDH1, CDKN2A
118.8CDKN2A, CDH1, IL8, MMP2
12
Cell adhesion ECM remodeling
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8.6MMP2, IL8, CDH1, TIMP1, TIMP2
13
Hide members
8.2MMP2, CDKN2A, HDAC10, TIMP1, TIMP2
14
Hide members
7.9TIMP2, TIMP1, CDKN2A, CDH1, IL8, IL2RG

Compounds for genes affiliated with Lung Giant Cell Carcinoma

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
1(4-aminophenyl)mercuric acetate4410.5TIMP1
2matrigel4410.2CDH1, NME1
3etoposide44 49 59 1113.0TIMP1, CDH1
4pge24410.0CDH1, MMP2
5methyl selenol449.8TIMP2, TIMP1, MMP2
6latanoprost44 1110.7TIMP1, TIMP2, MMP2
7polycarbonate449.7CDH1, MMP2, IL8
8chi 2449.7NME1, CDH1, TIMP2
9s-allylcysteine449.6CDH1, PCNA
10norcantharidin449.6TIMP2, PCNA, MMP2
11hydroxamate449.5MMP2, TIMP1, TIMP2
12cyclosporin a44 28 5911.4IL2RG, PCNA, TIMP2
13aprotinin44 1110.4MMP2, TIMP1, TIMP2, IL8
14gamma-linolenic acid44 2410.4PCNA, TIMP1, CDH1
15alendronate44 49 1111.3TIMP2, TIMP1, MMP2
16aspartate449.3KRT18, NME1, CDH1, CDKN2A
17temozolomide44 1110.3CDKN2A, MMP2, PCNA
18go 697644 5910.2CDH1, MMP2, IL8
19p00001449.2CDKN2A, TIMP2, CDH1
20o6-methylguanine449.2PCNA, CDH1, CDKN2A
21p002449.1NME1, CDH1, KRT18, TIMP1, TIMP2
22paclitaxel44 49 1111.1CDH1, CDKN2A, TIMP1, TIMP2
23cytochalasin d44 5910.0IL8, CDH1, TIMP2, MMP2, TIMP1
24hematoxylin449.0CDKN2A, CDH1, PCNA, KRT18
25herbimycin a44 5910.0TIMP1, CDH1, TIMP2, MMP2, IL8
26hyaluronic acid44 2410.0MMP2, IL8, CDH1, TIMP1, TIMP2
27sb 20358044 599.9CDH1, TIMP1, IL8, MMP2, TIMP2
28crcs448.9CDKN2A, NME1, CDH1
29pd 98,059448.9TIMP1, IL8, MMP2, CDH1, TIMP2
30ly294002448.9MMP2, IL8, CDH1, TIMP1, TIMP2
31actinomycin d448.9TIMP1, KRT18, CDKN2A, IL8, TIMP2
32mg 13244 599.8KRT18, IL8, PCNA, CDH1, CDKN2A
33serine448.7TIMP2, TIMP1, CDH1, IL8, MMP2, NME1
345-aza-2deoxycytidine448.6CDKN2A, PCNA, CDH1, TIMP1, TIMP2
35creatinine448.5CDKN2A, CDH1, MMP2, NME1, KRT18, TIMP2
36nitric oxide44 11 2410.5IL8, CDKN2A, TIMP2, TIMP1, NME1, KRT18
37dexamethasone44 49 28 1111.4PCNA, NME1, CDH1, CDKN2A, TIMP1, KRT18
38h2o2448.3MMP2, IL8, PCNA, TIMP2, CDKN2A, TIMP1
39azathioprine44 49 2 1111.3MMP2, PCNA, CDH1, TIMP2, TIMP1, CDKN2A
40methotrexate44 49 1110.3PCNA, CDH1, MMP2, CDKN2A, TIMP1, TIMP2
415fluorouracil448.0CDH1, TIMP2, CDKN2A, PCNA, MMP2, NME1
42n acetylcysteine448.0IL8, PCNA, CDH1, CDKN2A, TIMP1, KRT18
43genistein44 28 59 2 11 2413.0PCNA, TIMP2, TIMP1, CDKN2A, CDH1, MMP2
44lactate447.9TIMP2, TIMP1, IL8, MMP2, NME1, KRT18
45cysteine447.7MMP2, PCNA, IL8, TIMP2, TIMP1, CDKN2A
46paraffin447.7NME1, MMP2, PCNA, CDH1, CDKN2A, TIMP1
47progesterone44 59 28 11 2411.7PCNA, CDH1, KRT18, NME1, MMP2, CDKN2A
48alanine447.7TIMP1, CDH1, KRT18, PCNA, MMP2, NME1
49retinoic acid44 248.6TIMP2, TIMP1, CDKN2A, PCNA, MMP2, NME1
50vegf447.4MMP2, IL8, PCNA, CDH1, CDKN2A, NME1

GO Terms for genes affiliated with Lung Giant Cell Carcinoma

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16Gene Ontology
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Biological processes related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:0226179.0MMP2, TIMP1, TIMP2
2negative regulation of cell proliferationGO:0082859.0NME1, IL8, CDKN2A, TIMP2

Molecular functions related to Lung Giant Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:0081919.8TIMP1, TIMP2
2protein bindingGO:0055156.1KRT18, TIMP1, HDAC10, CDKN2A, CDH1, PCNA

Products for genes affiliated with Lung Giant Cell Carcinoma

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  • Antibodies
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Sources for Lung Giant Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet