Lung Large Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LNG035 MIFTS: 34	Lung Large Cell Carcinoma Categories: Rare diseases, Respiratory diseases, Neuronal diseases, Cancer diseases
Genes Variations Tissues Related diseases Publications Pathways Download Expand all tables

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Aliases & Classifications for Lung Large Cell Carcinoma

MalaCards integrated aliases for Lung Large Cell Carcinoma:

Name: Lung Large Cell Carcinoma ¹² ¹⁴

Large Cell Carcinoma of Lung ¹² ⁶⁹

Large Cell Lung Carcinoma ¹²

Large Cell Lung Cancer ⁵¹

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Respiratory diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4556

NCIt ⁴⁶ C4450

SNOMED-CT ⁶⁴ 254629004

UMLS ⁶⁹ C0345958

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Summaries for Lung Large Cell Carcinoma

MalaCards based summary : Lung Large Cell Carcinoma, also known as large cell carcinoma of lung, is related to lung cancer and lung mixed small cell and squamous cell carcinoma. An important gene associated with Lung Large Cell Carcinoma is ROS1 (ROS Proto-Oncogene 1, Receptor Tyrosine Kinase), and among its related pathways/superpathways are PEDF Induced Signaling and ERK Signaling. Affiliated tissues include lung, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : ⁷² Large-cell carcinoma (LCC) is a heterogeneous group of undifferentiated malignant neoplasms that lack... more...

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Related Diseases for Lung Large Cell Carcinoma

Diseases in the Lung Large Cell Carcinoma family:

Small Cell Cancer of the Lung	Lung Clear Cell Carcinoma
Small Cell Lung Cancer, Adult

Diseases related to Lung Large Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)

#	Related Disease	Score	Top Affiliating Genes
1	lung cancer	11.4
2	lung mixed small cell and squamous cell carcinoma	11.2
3	large cell carcinoma with rhabdoid phenotype	11.2
4	pulmonary large cell neuroendocrine carcinoma	11.0
5	large cell carcinoma	10.3
6	adenosquamous cell lung carcinoma	9.8	DDR2 ROS1
7	neutrophilia, hereditary	9.7
8	thrombocytosis	9.7
9	gingivitis	9.7
10	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	9.7
11	polyarteritis nodosa, childhood-onset	9.7
12	large cell neuroendocrine carcinoma	9.7
13	dermatomyositis	9.7
14	calcinosis	9.7
15	auditory system disease	9.7
16	inner ear disease	9.7
17	polyarteritis nodosa	9.7
18	autoimmune inner ear disease	9.7

Graphical network of the top 20 diseases related to Lung Large Cell Carcinoma:

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Symptoms & Phenotypes for Lung Large Cell Carcinoma

GenomeRNAi Phenotypes related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

²⁵ (show top 50) (show all 66)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	10.98	MTOR EPHA3
2	Decreased viability	GR00221-A-1	10.98	FGFR1 DDR2 MTOR BTK ROS1 WNK3
3	Decreased viability	GR00221-A-2	10.98	FGFR1 DDR2 EPHA5 BTK ROS1 TTN
4	Decreased viability	GR00221-A-3	10.98	EPHA5 BTK CDC42BPB
5	Decreased viability	GR00221-A-4	10.98	DDR2 MTOR EPHA3 EPHA5 BTK CDC42BPB
6	Decreased viability	GR00301-A	10.98	EPHA3 BTK
7	Decreased viability	GR00342-S-1	10.98	MTOR EPHA3 ROS1 TTN
8	Decreased viability	GR00342-S-2	10.98	MTOR
9	Decreased viability	GR00342-S-3	10.98	EPHA5 TTN
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-116	10.34	TRRAP
11	Decreased shRNA abundance (Z-score < -2)	GR00366-A-153	10.34	TRRAP
12	Decreased shRNA abundance (Z-score < -2)	GR00366-A-165	10.34	WNK3
13	Decreased shRNA abundance (Z-score < -2)	GR00366-A-173	10.34	MTOR
14	Decreased shRNA abundance (Z-score < -2)	GR00366-A-181	10.34	WNK3
15	Decreased shRNA abundance (Z-score < -2)	GR00366-A-213	10.34	TRRAP
16	Decreased shRNA abundance (Z-score < -2)	GR00366-A-26	10.34	TRRAP WNK3
17	Decreased shRNA abundance (Z-score < -2)	GR00366-A-53	10.34	MTOR
18	Decreased shRNA abundance (Z-score < -2)	GR00366-A-59	10.34	BTK
19	Decreased shRNA abundance (Z-score < -2)	GR00366-A-60	10.34	BTK MTOR TRRAP WNK3
20	Decreased shRNA abundance (Z-score < -2)	GR00366-A-68	10.34	TRRAP
21	Decreased shRNA abundance (Z-score < -2)	GR00366-A-84	10.34	TRRAP
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	10.3	DDR2
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	10.3	BTK
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	10.3	MTOR
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	10.3	MTOR
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-113	10.3	DDR2
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	10.3	ATR
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-12	10.3	NME1
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	10.3	WNK3
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-124	10.3	BTK
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-13	10.3	NME1
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-137	10.3	BTK
33	Increased shRNA abundance (Z-score > 2)	GR00366-A-140	10.3	BTK
34	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	10.3	MTOR DDR2
35	Increased shRNA abundance (Z-score > 2)	GR00366-A-166	10.3	ATR
36	Increased shRNA abundance (Z-score > 2)	GR00366-A-172	10.3	TRRAP NME1
37	Increased shRNA abundance (Z-score > 2)	GR00366-A-174	10.3	DDR2
38	Increased shRNA abundance (Z-score > 2)	GR00366-A-185	10.3	TRRAP
39	Increased shRNA abundance (Z-score > 2)	GR00366-A-186	10.3	DDR2
40	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	10.3	TRRAP
41	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	10.3	ATR
42	Increased shRNA abundance (Z-score > 2)	GR00366-A-2	10.3	ATR
43	Increased shRNA abundance (Z-score > 2)	GR00366-A-24	10.3	DDR2
44	Increased shRNA abundance (Z-score > 2)	GR00366-A-29	10.3	BTK WNK3
45	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	10.3	WNK3
46	Increased shRNA abundance (Z-score > 2)	GR00366-A-36	10.3	DDR2
47	Increased shRNA abundance (Z-score > 2)	GR00366-A-4	10.3	BTK
48	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	10.3	MTOR
49	Increased shRNA abundance (Z-score > 2)	GR00366-A-57	10.3	NME1
50	Increased shRNA abundance (Z-score > 2)	GR00366-A-69	10.3	WNK3

MGI Mouse Phenotypes related to Lung Large Cell Carcinoma:

⁴³

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.76	WNK3 ATR DDR2 EPHA3 FGFR1 MTOR
2	homeostasis/metabolism	MP:0005376	9.65	WNK3 ATR BTK DDR2 EPHA3 FGFR1
3	mortality/aging	MP:0010768	9.32	ATR BTK DDR2 EPHA3 FGFR1 MTOR

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Drugs & Therapeutics for Lung Large Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Lung Large Cell Carcinoma

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Genetic Tests for Lung Large Cell Carcinoma

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Anatomical Context for Lung Large Cell Carcinoma

MalaCards organs/tissues related to Lung Large Cell Carcinoma:

³⁸

Lung

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Publications for Lung Large Cell Carcinoma

Articles related to Lung Large Cell Carcinoma:

#	Title	Authors	Year
1	Oxidative stress associates with aggressiveness in lung large-cell carcinoma. ( 25638031 )	da Motta L.L....Klamt F.	2015
2	Toona sinensis extracts induced cell cycle arrest and apoptosis in the human lung large cell carcinoma. ( 20123594 )	Wang C.Y....Huang M.S.	2010
3	Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model. ( 20077433 )	Su C.C....Chung J.G.	2010
4	Lung large cell carcinoma producing granulocyte-colony-stimulating factor. ( 17184692 )	Hasegawa S....Hattori Y.	2007
5	Primary lung large cell carcinoma metastatic to the vulva: a case report and review of the literature. ( 15350382 )	Rocconi R.P....Conner M.G.	2004
6	Establishment and characterization of a cell line, KaMi, from human lung large cell carcinoma. ( 1279943 )	Takata H....Akagi T.	1992

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Genes for Lung Large Cell Carcinoma

Genes related to Lung Large Cell Carcinoma (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Implication	PubmedIds
1	ROS1	ROS Proto-Oncogene 1, Receptor Tyrosine Kinase	Protein Coding	23.27	DISEASES inferred ¹⁴ GeneCards inferred via : Variants (show sections)
2	TRRAP	Transformation/Transcription Domain Associated Protein	Protein Coding	22.15	DISEASES inferred ¹⁴ GeneCards inferred via : Variants (show sections)
3	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	22.02	DISEASES inferred ¹⁴ GeneCards inferred via : Variants (show sections)
4	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	21.42	DISEASES inferred ¹⁴ Novoseek inferred ⁵¹ GeneCards inferred via : DISEASES inferred (show sections)	17167724 18440302 15757527
5	TTN	Titin	Protein Coding	18.95	GeneCards inferred via : Variants (show sections)
6	MYO18B	Myosin XVIIIB	Protein Coding	18.95	GeneCards inferred via : Variants (show sections)
7	EPHA5	EPH Receptor A5	Protein Coding	18.74	GeneCards inferred via : Variants (show sections)
8	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	18.4	GeneCards inferred via : Variants (show sections)
9	WNK3	WNK Lysine Deficient Protein Kinase 3	Protein Coding	18.4	GeneCards inferred via : Variants (show sections)
10	ATR	ATR Serine/Threonine Kinase	Protein Coding	18.4	GeneCards inferred via : Variants (show sections)
11	DDR2	Discoidin Domain Receptor Tyrosine Kinase 2	Protein Coding	18.4	GeneCards inferred via : Variants (show sections)
12	CDC42BPB	CDC42 Binding Protein Kinase Beta	Protein Coding	18.4	GeneCards inferred via : Variants (show sections)
13	EPHA3	EPH Receptor A3	Protein Coding	18.4	GeneCards inferred via : Variants (show sections)
14	BTK	Bruton Tyrosine Kinase	Protein Coding	18.4	GeneCards inferred via : Variants (show sections)

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Variations for Lung Large Cell Carcinoma

Cosmic variations for Lung Large Cell Carcinoma:

⁹ (show top 50) (show all 530)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	Conf
1	COSM21262	WNK3	lung,NS,carcinoma,large cell carcinoma	c.4599G>T	p.L1533F	15
2	COSM12945	TTBK1	lung,NS,carcinoma,large cell carcinoma	c.2417C>T	p.S806F	15
3	COSM12943	TRRAP	lung,NS,carcinoma,large cell carcinoma	c.8015C>T	p.P2672L	15
4	COSM12942	TRPM6	lung,NS,carcinoma,large cell carcinoma	c.3021G>C	p.W1007C	15
5	COSM10660	TP53	lung,NS,carcinoma,large cell carcinoma	c.818G>A	p.R273H	15
6	COSM10687	TP53	lung,NS,carcinoma,large cell carcinoma	c.527G>A	p.C176Y	15
7	COSM45268	TP53	lung,NS,carcinoma,large cell carcinoma	c.827C>A	p.A276D	15
8	COSM43549	TP53	lung,NS,carcinoma,large cell carcinoma	c.481G>T	p.A161S	15
9	COSM10889	TP53	lung,NS,carcinoma,large cell carcinoma	c.536A>G	p.H179R	15
10	COSM44204	TP53	lung,NS,carcinoma,large cell carcinoma	c.423C>G	p.C141W	15
11	COSM43568	TP53	lung,NS,carcinoma,large cell carcinoma	c.772G>T	p.E258*	15
12	COSM43963	TP53	lung,NS,carcinoma,large cell carcinoma	c.396G>C	p.K132N	15
13	COSM10659	TP53	lung,NS,carcinoma,large cell carcinoma	c.817C>T	p.R273C	15
14	COSM11196	TP53	lung,NS,carcinoma,large cell carcinoma	c.734G>T	p.G245V	15
15	COSM45351	TP53	lung,NS,carcinoma,large cell carcinoma	c.434T>G	p.L145R	15
16	COSM6932	TP53	lung,NS,carcinoma,large cell carcinoma	c.733G>A	p.G245S	15
17	COSM44133	TP53	lung,NS,carcinoma,large cell carcinoma	c.859G>T	p.E287*	15
18	COSM3849376	TP53	lung,NS,carcinoma,large cell carcinoma	c.753C>G	p.I251M	15
19	COSM11514	TP53	lung,NS,carcinoma,large cell carcinoma	c.1001G>T	p.G334V	15
20	COSM11188	TP53	lung,NS,carcinoma,large cell carcinoma	c.412G>C	p.A138P	15
21	COSM10887	TP53	lung,NS,carcinoma,large cell carcinoma	c.833C>G	p.P278R	15
22	COSM10733	TP53	lung,NS,carcinoma,large cell carcinoma	c.574C>T	p.Q192*	15
23	COSM6081949	TP53	lung,NS,carcinoma,large cell carcinoma	c.1060C>T	p.Q354*	15
24	COSM43779	TP53	lung,NS,carcinoma,large cell carcinoma	c.589G>A	p.V197M	15
25	COSM44633	TP53	lung,NS,carcinoma,large cell carcinoma	c.583A>T	p.I195F	15
26	COSM10770	TP53	lung,NS,carcinoma,large cell carcinoma	c.1045G>T	p.E349*	15
27	COSM11333	TP53	lung,NS,carcinoma,large cell carcinoma	c.499C>T	p.Q167*	15
28	COSM44398	TP53	lung,NS,carcinoma,large cell carcinoma	c.682G>A	p.D228N	15
29	COSM10726	TP53	lung,NS,carcinoma,large cell carcinoma	c.856G>A	p.E286K	15
30	COSM11392	TP53	lung,NS,carcinoma,large cell carcinoma	c.800G>C	p.R267P	15
31	COSM10810	TP53	lung,NS,carcinoma,large cell carcinoma	c.725G>T	p.C242F	15
32	COSM10648	TP53	lung,NS,carcinoma,large cell carcinoma	c.524G>A	p.R175H	15
33	COSM11073	TP53	lung,NS,carcinoma,large cell carcinoma	c.1024C>T	p.R342*	15
34	COSM10859	TP53	lung,NS,carcinoma,large cell carcinoma	c.814G>T	p.V272L	15
35	COSM10941	TP53	lung,NS,carcinoma,large cell carcinoma	c.730G>A	p.G244S	15
36	COSM43812	TP53	lung,NS,carcinoma,large cell carcinoma	c.277C>A	p.L93M	15
37	COSM11323	TP53	lung,NS,carcinoma,large cell carcinoma	c.482C>A	p.A161D	15
38	COSM44327	TP53	lung,NS,carcinoma,large cell carcinoma	c.518T>C	p.V173A	15
39	COSM10654	TP53	lung,NS,carcinoma,large cell carcinoma	c.637C>T	p.R213*	15
40	COSM44621	TP53	lung,NS,carcinoma,large cell carcinoma	c.718A>T	p.S240C	15
41	COSM10646	TP53	lung,NS,carcinoma,large cell carcinoma	c.725G>A	p.C242Y	15
42	COSM45677	TP53	lung,NS,carcinoma,large cell carcinoma	c.714T>A	p.C238*	15
43	COSM44439	TP53	lung,NS,carcinoma,large cell carcinoma	c.656C>T	p.P219L	15
44	COSM43947	TP53	lung,NS,carcinoma,large cell carcinoma	c.614A>G	p.Y205C	15
45	COSM45675	TP53	lung,NS,carcinoma,large cell carcinoma	c.673-1G>C	p.?	15
46	COSM21593	TP53	lung,NS,carcinoma,large cell carcinoma	c.358A>T	p.K120*	15
47	COSM10788	TP53	lung,NS,carcinoma,large cell carcinoma	c.764T>G	p.I255S	15
48	COSM43626	TP53	lung,NS,carcinoma,large cell carcinoma	c.475G>A	p.A159T	15
49	COSM44891	TP53	lung,NS,carcinoma,large cell carcinoma	c.796G>T	p.G266*	15
50	COSM10750	TP53	lung,NS,carcinoma,large cell carcinoma	c.490A>T	p.K164*	15

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Expression for Lung Large Cell Carcinoma

Search GEO for disease gene expression data for Lung Large Cell Carcinoma.

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Pathways for Lung Large Cell Carcinoma

Pathways related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PEDF Induced Signaling ⁶⁰ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁰ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶⁰ Glucocorticoid Receptor Signaling ⁶⁰ IL-6 Pathway ⁶⁰ MIF Mediated Glucocorticoid Regulation ⁶⁰ MIF Regulation of Innate Immune Cells ⁶⁰ NFAT Signaling and Lymphocyte Interactions ⁶⁰ PGC1Alpha Pathway ⁶⁰ RAR-Gamma-RXR-Alpha Degradation ⁶⁰ STAT3 Pathway ⁶⁰	13.34	BTK DDR2 EPHA3 EPHA5 FGFR1 MTOR
2	ERK Signaling ⁶⁰ Show member pathways ILK Signaling ⁶⁰ MAPK Signaling ⁶⁰ Molecular Mechanisms of Cancer ⁶⁰ Rho Family GTPases ⁶⁰	13.28	ATR BTK DDR2 EPHA3 EPHA5 FGFR1
3	TGF-Beta Pathway ⁶⁰ Show member pathways JAK-STAT Pathway ⁶⁰ JNK Pathway ⁶⁰ MAPK Family Pathway ⁶⁰ Regulation of eIF4 and p70S6K ⁶⁰ SOCS Pathway ⁶⁰	13.15	BTK DDR2 EPHA3 EPHA5 FGFR1 MTOR
4	Akt Signaling ⁶⁰ Show member pathways p38 Signaling ⁶⁰ Tec Kinases Signaling ⁶⁰	13.01	BTK DDR2 EPHA3 EPHA5 FGFR1 MTOR
5	CREB Pathway ⁶⁰ Show member pathways Activation of PKC through GPCR ⁶⁰ Intracellular Calcium Signaling ⁶⁰ IP3 Pathway ⁶⁰	12.96	BTK DDR2 EPHA3 EPHA5 FGFR1 ROS1
6	p70S6K Signaling ⁶⁰ Show member pathways mTOR Pathway ⁶⁰ Renin-Angiotensin Pathway ⁶⁰	12.71	DDR2 EPHA3 EPHA5 FGFR1 MTOR
7	Actin Nucleation by ARP-WASP Complex ⁶⁰ Show member pathways Actin Nucleation and Branching ⁶⁰ CDC42 Pathway ⁶⁰ RhoA Pathway ⁶⁰	12.57	DDR2 EPHA3 EPHA5 FGFR1 MYO18B ROS1
8	Tyrosine Kinases / Adaptors ⁴	11.26	BTK DDR2 EPHA3 EPHA5 FGFR1 ROS1
9	G-protein signaling_Rap2B regulation pathway ²¹	10.34	BTK DDR2 EPHA3 EPHA5 FGFR1 ROS1

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GO Terms for Lung Large Cell Carcinoma

Biological processes related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein autophosphorylation	GO:0046777	9.73	ATR BTK DDR2 FGFR1 MTOR WNK3
2	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.72	BTK DDR2 EPHA3 EPHA5 ROS1
3	peptidyl-tyrosine phosphorylation	GO:0018108	9.7	BTK DDR2 EPHA3 EPHA5 FGFR1 ROS1
4	positive regulation of neuron projection development	GO:0010976	9.67	EPHA3 FGFR1 MTOR NME1
5	cell migration	GO:0016477	9.65	CDC42BPB EPHA3 FGFR1
6	protein phosphorylation	GO:0006468	9.65	BTK CDC42BPB DDR2 EPHA3 EPHA5 FGFR1
7	regulation of GTPase activity	GO:0043087	9.63	EPHA3 EPHA5 MTOR
8	regulation of actin cytoskeleton organization	GO:0032956	9.58	EPHA3 EPHA5 MTOR
9	phosphorylation	GO:0016310	9.44	ATR BTK CDC42BPB DDR2 EPHA3 EPHA5
10	cardiac muscle fiber development	GO:0048739	9.43	MYO18B TTN

Molecular functions related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:0005524	9.97	ATR BTK CDC42BPB DDR2 EPHA3 EPHA5
2	protein tyrosine kinase activity	GO:0004713	9.87	BTK DDR2 EPHA3 EPHA5 FGFR1 ROS1
3	protein serine/threonine kinase activity	GO:0004674	9.8	ATR CDC42BPB MTOR TTN WNK3
4	transmembrane receptor protein tyrosine kinase activity	GO:0004714	9.77	DDR2 EPHA3 EPHA5 FGFR1 ROS1
5	protein kinase activity	GO:0004672	9.7	ATR BTK CDC42BPB DDR2 EPHA3 EPHA5
6	ephrin receptor activity	GO:0005003	9.46	EPHA3 EPHA5
7	kinase activity	GO:0016301	9.44	ATR BTK CDC42BPB DDR2 EPHA3 EPHA5
8	GPI-linked ephrin receptor activity	GO:0005004	9.43	EPHA3 EPHA5
9	transferase activity	GO:0016740	10.07	ATR BTK CDC42BPB DDR2 EPHA3 EPHA5

Sources

Sources for Lung Large Cell Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ ExPASy

¹⁷ FDA Approved Drugs

¹⁸ FMA

¹⁹ GeneAnalytics

²⁰ GeneCards

²¹ GeneGo (Thomson Reuters)

²² GeneHancer via GeneCards

²³ GeneReviews

²⁴ Genetics Home Reference

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HGMD

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ MalaCards

³⁹ MedGen

⁴⁰ MedlinePlus

⁴¹ MeSH

⁴² MESH via Orphanet

⁴³ MGI

⁴⁴ NCBI Bookshelf

⁴⁵ NCI

⁴⁶ NCIt

⁴⁷ NDF-RT

⁴⁸ NIH Clinical Center

⁴⁹ NIH Rare Diseases

⁵⁰ NINDS

⁵¹ Novoseek

⁵² Novus Biologicals

⁵³ OMIM

⁵⁴ OMIM via Orphanet

⁵⁵ Orphanet

⁵⁶ PathCards

⁵⁷ PharmGKB

⁵⁸ PubMed

⁵⁹ PubMed Health

⁶⁰ QIAGEN

⁶¹ R&D Systems

⁶² Reactome

⁶³ Sino Biological

⁶⁴ SNOMED-CT

⁶⁵ SNOMED-CT via HPO

⁶⁶ SNOMED-CT via Orphanet

⁶⁷ TGDB

⁶⁸ Tocris

⁶⁹ UMLS

⁷⁰ UMLS via Orphanet

⁷¹ UniProtKB/Swiss-Prot

⁷² Wikipedia