MCID: LNG035
MIFTS: 34

Lung Large Cell Carcinoma

Categories: Rare diseases, Respiratory diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Lung Large Cell Carcinoma

MalaCards integrated aliases for Lung Large Cell Carcinoma:

Name: Lung Large Cell Carcinoma 12 14
Large Cell Carcinoma of Lung 12 69
Large Cell Lung Carcinoma 12
Large Cell Lung Cancer 51

Classifications:



External Ids:

Disease Ontology 12 DOID:4556
NCIt 46 C4450
SNOMED-CT 64 254629004
UMLS 69 C0345958

Summaries for Lung Large Cell Carcinoma

MalaCards based summary : Lung Large Cell Carcinoma, also known as large cell carcinoma of lung, is related to lung cancer and lung mixed small cell and squamous cell carcinoma. An important gene associated with Lung Large Cell Carcinoma is ROS1 (ROS Proto-Oncogene 1, Receptor Tyrosine Kinase), and among its related pathways/superpathways are PEDF Induced Signaling and ERK Signaling. Affiliated tissues include lung, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 72 Large-cell carcinoma (LCC) is a heterogeneous group of undifferentiated malignant neoplasms that lack... more...

Related Diseases for Lung Large Cell Carcinoma

Graphical network of the top 20 diseases related to Lung Large Cell Carcinoma:



Diseases related to Lung Large Cell Carcinoma

Symptoms & Phenotypes for Lung Large Cell Carcinoma

GenomeRNAi Phenotypes related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

25 (show top 50) (show all 66)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.98 MTOR EPHA3
2 Decreased viability GR00221-A-1 10.98 FGFR1 DDR2 MTOR BTK ROS1 WNK3
3 Decreased viability GR00221-A-2 10.98 FGFR1 DDR2 EPHA5 BTK ROS1 TTN
4 Decreased viability GR00221-A-3 10.98 EPHA5 BTK CDC42BPB
5 Decreased viability GR00221-A-4 10.98 DDR2 MTOR EPHA3 EPHA5 BTK CDC42BPB
6 Decreased viability GR00301-A 10.98 EPHA3 BTK
7 Decreased viability GR00342-S-1 10.98 MTOR EPHA3 ROS1 TTN
8 Decreased viability GR00342-S-2 10.98 MTOR
9 Decreased viability GR00342-S-3 10.98 EPHA5 TTN
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 10.34 TRRAP
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10.34 TRRAP
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 10.34 WNK3
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10.34 MTOR
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 10.34 WNK3
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 10.34 TRRAP
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 10.34 TRRAP WNK3
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.34 MTOR
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 10.34 BTK
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 10.34 BTK MTOR TRRAP WNK3
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 10.34 TRRAP
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 10.34 TRRAP
22 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.3 DDR2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.3 BTK
24 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.3 MTOR
25 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.3 MTOR
26 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.3 DDR2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.3 ATR
28 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.3 NME1
29 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.3 WNK3
30 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.3 BTK
31 Increased shRNA abundance (Z-score > 2) GR00366-A-13 10.3 NME1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.3 BTK
33 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.3 BTK
34 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.3 MTOR DDR2
35 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.3 ATR
36 Increased shRNA abundance (Z-score > 2) GR00366-A-172 10.3 TRRAP NME1
37 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.3 DDR2
38 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.3 TRRAP
39 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.3 DDR2
40 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.3 TRRAP
41 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.3 ATR
42 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.3 ATR
43 Increased shRNA abundance (Z-score > 2) GR00366-A-24 10.3 DDR2
44 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.3 BTK WNK3
45 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.3 WNK3
46 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.3 DDR2
47 Increased shRNA abundance (Z-score > 2) GR00366-A-4 10.3 BTK
48 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.3 MTOR
49 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.3 NME1
50 Increased shRNA abundance (Z-score > 2) GR00366-A-69 10.3 WNK3

MGI Mouse Phenotypes related to Lung Large Cell Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 WNK3 ATR DDR2 EPHA3 FGFR1 MTOR
2 homeostasis/metabolism MP:0005376 9.65 WNK3 ATR BTK DDR2 EPHA3 FGFR1
3 mortality/aging MP:0010768 9.32 ATR BTK DDR2 EPHA3 FGFR1 MTOR

Drugs & Therapeutics for Lung Large Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Lung Large Cell Carcinoma

Genetic Tests for Lung Large Cell Carcinoma

Anatomical Context for Lung Large Cell Carcinoma

MalaCards organs/tissues related to Lung Large Cell Carcinoma:

38
Lung

Publications for Lung Large Cell Carcinoma

Articles related to Lung Large Cell Carcinoma:

# Title Authors Year
1
Oxidative stress associates with aggressiveness in lung large-cell carcinoma. ( 25638031 )
2015
2
Toona sinensis extracts induced cell cycle arrest and apoptosis in the human lung large cell carcinoma. ( 20123594 )
2010
3
Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model. ( 20077433 )
2010
4
Lung large cell carcinoma producing granulocyte-colony-stimulating factor. ( 17184692 )
2007
5
Primary lung large cell carcinoma metastatic to the vulva: a case report and review of the literature. ( 15350382 )
2004
6
Establishment and characterization of a cell line, KaMi, from human lung large cell carcinoma. ( 1279943 )
1992

Variations for Lung Large Cell Carcinoma

Cosmic variations for Lung Large Cell Carcinoma:

9 (show top 50) (show all 530)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM21262 WNK3 lung,NS,carcinoma,large cell carcinoma c.4599G>T p.L1533F 15
2 COSM12945 TTBK1 lung,NS,carcinoma,large cell carcinoma c.2417C>T p.S806F 15
3 COSM12943 TRRAP lung,NS,carcinoma,large cell carcinoma c.8015C>T p.P2672L 15
4 COSM12942 TRPM6 lung,NS,carcinoma,large cell carcinoma c.3021G>C p.W1007C 15
5 COSM10660 TP53 lung,NS,carcinoma,large cell carcinoma c.818G>A p.R273H 15
6 COSM10687 TP53 lung,NS,carcinoma,large cell carcinoma c.527G>A p.C176Y 15
7 COSM45268 TP53 lung,NS,carcinoma,large cell carcinoma c.827C>A p.A276D 15
8 COSM43549 TP53 lung,NS,carcinoma,large cell carcinoma c.481G>T p.A161S 15
9 COSM10889 TP53 lung,NS,carcinoma,large cell carcinoma c.536A>G p.H179R 15
10 COSM44204 TP53 lung,NS,carcinoma,large cell carcinoma c.423C>G p.C141W 15
11 COSM43568 TP53 lung,NS,carcinoma,large cell carcinoma c.772G>T p.E258* 15
12 COSM43963 TP53 lung,NS,carcinoma,large cell carcinoma c.396G>C p.K132N 15
13 COSM10659 TP53 lung,NS,carcinoma,large cell carcinoma c.817C>T p.R273C 15
14 COSM11196 TP53 lung,NS,carcinoma,large cell carcinoma c.734G>T p.G245V 15
15 COSM45351 TP53 lung,NS,carcinoma,large cell carcinoma c.434T>G p.L145R 15
16 COSM6932 TP53 lung,NS,carcinoma,large cell carcinoma c.733G>A p.G245S 15
17 COSM44133 TP53 lung,NS,carcinoma,large cell carcinoma c.859G>T p.E287* 15
18 COSM3849376 TP53 lung,NS,carcinoma,large cell carcinoma c.753C>G p.I251M 15
19 COSM11514 TP53 lung,NS,carcinoma,large cell carcinoma c.1001G>T p.G334V 15
20 COSM11188 TP53 lung,NS,carcinoma,large cell carcinoma c.412G>C p.A138P 15
21 COSM10887 TP53 lung,NS,carcinoma,large cell carcinoma c.833C>G p.P278R 15
22 COSM10733 TP53 lung,NS,carcinoma,large cell carcinoma c.574C>T p.Q192* 15
23 COSM6081949 TP53 lung,NS,carcinoma,large cell carcinoma c.1060C>T p.Q354* 15
24 COSM43779 TP53 lung,NS,carcinoma,large cell carcinoma c.589G>A p.V197M 15
25 COSM44633 TP53 lung,NS,carcinoma,large cell carcinoma c.583A>T p.I195F 15
26 COSM10770 TP53 lung,NS,carcinoma,large cell carcinoma c.1045G>T p.E349* 15
27 COSM11333 TP53 lung,NS,carcinoma,large cell carcinoma c.499C>T p.Q167* 15
28 COSM44398 TP53 lung,NS,carcinoma,large cell carcinoma c.682G>A p.D228N 15
29 COSM10726 TP53 lung,NS,carcinoma,large cell carcinoma c.856G>A p.E286K 15
30 COSM11392 TP53 lung,NS,carcinoma,large cell carcinoma c.800G>C p.R267P 15
31 COSM10810 TP53 lung,NS,carcinoma,large cell carcinoma c.725G>T p.C242F 15
32 COSM10648 TP53 lung,NS,carcinoma,large cell carcinoma c.524G>A p.R175H 15
33 COSM11073 TP53 lung,NS,carcinoma,large cell carcinoma c.1024C>T p.R342* 15
34 COSM10859 TP53 lung,NS,carcinoma,large cell carcinoma c.814G>T p.V272L 15
35 COSM10941 TP53 lung,NS,carcinoma,large cell carcinoma c.730G>A p.G244S 15
36 COSM43812 TP53 lung,NS,carcinoma,large cell carcinoma c.277C>A p.L93M 15
37 COSM11323 TP53 lung,NS,carcinoma,large cell carcinoma c.482C>A p.A161D 15
38 COSM44327 TP53 lung,NS,carcinoma,large cell carcinoma c.518T>C p.V173A 15
39 COSM10654 TP53 lung,NS,carcinoma,large cell carcinoma c.637C>T p.R213* 15
40 COSM44621 TP53 lung,NS,carcinoma,large cell carcinoma c.718A>T p.S240C 15
41 COSM10646 TP53 lung,NS,carcinoma,large cell carcinoma c.725G>A p.C242Y 15
42 COSM45677 TP53 lung,NS,carcinoma,large cell carcinoma c.714T>A p.C238* 15
43 COSM44439 TP53 lung,NS,carcinoma,large cell carcinoma c.656C>T p.P219L 15
44 COSM43947 TP53 lung,NS,carcinoma,large cell carcinoma c.614A>G p.Y205C 15
45 COSM45675 TP53 lung,NS,carcinoma,large cell carcinoma c.673-1G>C p.? 15
46 COSM21593 TP53 lung,NS,carcinoma,large cell carcinoma c.358A>T p.K120* 15
47 COSM10788 TP53 lung,NS,carcinoma,large cell carcinoma c.764T>G p.I255S 15
48 COSM43626 TP53 lung,NS,carcinoma,large cell carcinoma c.475G>A p.A159T 15
49 COSM44891 TP53 lung,NS,carcinoma,large cell carcinoma c.796G>T p.G266* 15
50 COSM10750 TP53 lung,NS,carcinoma,large cell carcinoma c.490A>T p.K164* 15

Expression for Lung Large Cell Carcinoma

Search GEO for disease gene expression data for Lung Large Cell Carcinoma.

Pathways for Lung Large Cell Carcinoma

Pathways related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 BTK DDR2 EPHA3 EPHA5 FGFR1 MTOR
2
Show member pathways
13.28 ATR BTK DDR2 EPHA3 EPHA5 FGFR1
3
Show member pathways
13.15 BTK DDR2 EPHA3 EPHA5 FGFR1 MTOR
4
Show member pathways
13.01 BTK DDR2 EPHA3 EPHA5 FGFR1 MTOR
5
Show member pathways
12.96 BTK DDR2 EPHA3 EPHA5 FGFR1 ROS1
6
Show member pathways
12.71 DDR2 EPHA3 EPHA5 FGFR1 MTOR
7
Show member pathways
12.57 DDR2 EPHA3 EPHA5 FGFR1 MYO18B ROS1
8 11.26 BTK DDR2 EPHA3 EPHA5 FGFR1 ROS1
9 10.34 BTK DDR2 EPHA3 EPHA5 FGFR1 ROS1

GO Terms for Lung Large Cell Carcinoma

Biological processes related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein autophosphorylation GO:0046777 9.73 ATR BTK DDR2 FGFR1 MTOR WNK3
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.72 BTK DDR2 EPHA3 EPHA5 ROS1
3 peptidyl-tyrosine phosphorylation GO:0018108 9.7 BTK DDR2 EPHA3 EPHA5 FGFR1 ROS1
4 positive regulation of neuron projection development GO:0010976 9.67 EPHA3 FGFR1 MTOR NME1
5 cell migration GO:0016477 9.65 CDC42BPB EPHA3 FGFR1
6 protein phosphorylation GO:0006468 9.65 BTK CDC42BPB DDR2 EPHA3 EPHA5 FGFR1
7 regulation of GTPase activity GO:0043087 9.63 EPHA3 EPHA5 MTOR
8 regulation of actin cytoskeleton organization GO:0032956 9.58 EPHA3 EPHA5 MTOR
9 phosphorylation GO:0016310 9.44 ATR BTK CDC42BPB DDR2 EPHA3 EPHA5
10 cardiac muscle fiber development GO:0048739 9.43 MYO18B TTN

Molecular functions related to Lung Large Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.97 ATR BTK CDC42BPB DDR2 EPHA3 EPHA5
2 protein tyrosine kinase activity GO:0004713 9.87 BTK DDR2 EPHA3 EPHA5 FGFR1 ROS1
3 protein serine/threonine kinase activity GO:0004674 9.8 ATR CDC42BPB MTOR TTN WNK3
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.77 DDR2 EPHA3 EPHA5 FGFR1 ROS1
5 protein kinase activity GO:0004672 9.7 ATR BTK CDC42BPB DDR2 EPHA3 EPHA5
6 ephrin receptor activity GO:0005003 9.46 EPHA3 EPHA5
7 kinase activity GO:0016301 9.44 ATR BTK CDC42BPB DDR2 EPHA3 EPHA5
8 GPI-linked ephrin receptor activity GO:0005004 9.43 EPHA3 EPHA5
9 transferase activity GO:0016740 10.07 ATR BTK CDC42BPB DDR2 EPHA3 EPHA5

Sources for Lung Large Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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