MCID: LNG039
MIFTS: 45

Lung Squamous Cell Carcinoma malady

Skin diseases, Respiratory diseases, Cancer diseases categories

Summaries for Lung Squamous Cell Carcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung... more...

MalaCards: Lung Squamous Cell Carcinoma, also known as squamous cell carcinoma of lung, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Lung Squamous Cell Carcinoma is TSPYL5 (TSPY-like 5), and among its related pathways are Leukocyte transendothelial migration and Integrin Pathway. The compounds calcium and ochratoxin a have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and endothelial.

Aliases & Classifications for Lung Squamous Cell Carcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Respiratory diseases


Aliases & Descriptions:

lung squamous cell carcinoma 8 10
squamous cell carcinoma of lung 8 60
epidermoid cell carcinoma of the lung 8
squamous cell lung cancer 44


External Ids:

Disease Ontology8 DOID:3907
SNOMED-CT56 254634000
NCIt39 C3493

Related Diseases for Lung Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Lung Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.9CLDN7, KLK10, S100A2, S100A7, AREG, SNAI2
2adenocarcinoma31.2S100A2, AREG, NAPSA, CLDN5, CLDN3, CLDN4
3lung cancer30.7NAPSA
4lung adenocarcinoma10.8
5small cell carcinoma10.5
6lung small cell carcinoma10.5
7bone carcinoma10.4
8parathyroid carcinoma10.3
9pulmonary alveolar proteinosis10.3
10lung lymphoma10.3
11large cell carcinoma10.3
12lung large cell carcinoma10.3
13acanthosis nigricans10.2
14burns10.2
15cortical thymoma10.2
16gastric lymphoma10.2
17nevoid basal cell carcinoma syndrome10.2
18colon squamous cell carcinoma10.2
19gastric squamous cell carcinoma10.2
20lung giant cell carcinoma10.2
21squamous papillomatosis10.2
22asbestos-related lung carcinoma10.2
23gynecomastia10.2
24hypercalcemia10.2
25adenosquamous carcinoma10.2
26adenosquamous cell lung carcinoma10.2
27breast adenocarcinoma10.2
28breast squamous cell carcinoma10.2
29cholangiocarcinoma10.2
30colon adenocarcinoma10.2
31gingivitis10.2
32intrahepatic cholangiocarcinoma10.2
33marginal zone b-cell lymphoma10.2
34pleurisy10.2
35renal cell carcinoma10.2
36skin squamous cell carcinoma10.2
37thymic carcinoma10.2
38thymoma10.2
39transitional cell carcinoma10.2
40pulmonary tuberculosis10.2
41neuronitis10.2
42acute myocardial infarction10.2
43cell type cancer10.2
44myelofibrosis10.2
45myocardial infarction10.2
46tuberculosis10.2
47vascular cancer10.2
48psoriasis10.0S100A2, S100A7, AREG
49stomach cancer10.0KLK10, AREG, CLDN3, CLDN4, CLDN7
50ovarian cystadenoma10.0CLDN4, AREG

Graphical network of the top 20 diseases related to Lung Squamous Cell Carcinoma:



Diseases related to lung squamous cell carcinoma

Clinical Features for Lung Squamous Cell Carcinoma

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Drugs & Therapeutics for Lung Squamous Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lung Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Lung Squamous Cell Carcinoma

Search NIH Clinical Center for Lung Squamous Cell Carcinoma

Search CenterWatch for Lung Squamous Cell Carcinoma

Genetic Tests for Lung Squamous Cell Carcinoma

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Anatomical Context for Lung Squamous Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Lung Squamous Cell Carcinoma:

32
Lung, Bone, Endothelial, Prostate, Colon, Brain, Lymph node, Breast, B cells, T cells, Cervix, Skin, Tongue, Thyroid, Small intestine, Bronchial epithelium

Animal Models for Lung Squamous Cell Carcinoma or affiliated genes

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Publications for Lung Squamous Cell Carcinoma

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50PubMed
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Articles related to Lung Squamous Cell Carcinoma:

(show top 50)    (show all 422)
idTitleAuthorsYear
1
Concurrent Lung Squamous Cell Carcinoma and Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-associated Lymphoid Tissue Type. (24419198)
2014
2
The pivotal role of IKKI+ in the development of spontaneous lung squamous cell carcinomas. (23597566)
2013
3
Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites. (23742673)
2013
4
Lung Squamous Cell Carcinoma in a Young Female Never Smoker: A Case Report. (23558225)
2013
5
DeltaN TP63 reactivation, epithelial phenotype maintenance, and survival in lung squamous cell carcinoma. (21986963)
2012
6
Expression of long non-coding ribonucleic acid metastasis-associated lung adenocarcinoma transcript-1 is correlated with progress and apoptosis of laryngeal squamous cell carcinoma. (23104528)
2012
7
Differences in metabolism between adeno- and squamous cell non-small cell lung carcinomas: spatial distribution and prognostic value of GLUT1 and MCT4. (22153830)
2012
8
Increased FGFR1 copy number in lung squamous cell carcinomas. (22179561)
2012
9
Human papillomavirus DNA and p16 gene in squamous cell lung carcinoma. (22843877)
2012
10
A case of lung squamous cell carcinoma with metastases to the duodenum and small intestine. (22026313)
2011
11
High podoplanin expression in cancer cells predicts lower incidence of nodal metastasis in patients with lung squamous cell carcinoma. (21194851)
2011
12
CAFET algorithm reveals Wnt/PCP signature in lung squamous cell carcinoma. (22016777)
2011
13
A case of squamous cell carcinoma of lung presenting with paraneoplastic type of acanthosis nigricans. (21654990)
2011
14
A metastatic jejunal tumor from squamous cell carcinoma of the lung found in an intestinal perforation. (22171215)
2011
15
Immunohistochemical staining with deltaNp63 is useful for distinguishing the squamous cell component of adenosquamous cell carcinoma of the lung. (21115930)
2010
16
Cytokeratin expression profiling is useful for distinguishing between primary squamous cell carcinoma of the lung and pulmonary metastases from tongue cancer. (20618735)
2010
17
High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]. (20840813)
2010
18
Acute cholangitis due to pancreatic metastasis from squamous cell lung carcinoma: a case report and review of literature. (20062690)
2009
19
Epithelial-to-mesenchymal transition in the development and progression of adenocarcinoma and squamous cell carcinoma of the lung. (19270647)
2009
20
CHFR expression is preferentially impaired in smoking-related squamous cell carcinoma of the lung, and the diminished expression significantly harms outcomes. (18623126)
2008
21
Interaction between CYP1A2-T2467DELT polymorphism and smoking in adenocarcinoma and squamous cell carcinoma of the lung. (17509724)
2007
22
Immunohistochemical expression of aminopeptidase N (CD13) in human lung squamous cell carcinomas, with special reference to Bestatin adjuvant therapy. (16704492)
2006
23
Polymorphism of Xeroderma Pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagus. (16094634)
2006
24
Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by gamma-irradiation. (16969512)
2006
25
TPX2 expression and its significance in squamous cell carcinoma of lung]. (17134548)
2006
26
Expression of the p16(INK4a) gene product, methylation of the p16(INK4a) promoter region and expression of the polycomb-group gene BMI-1 in squamous cell lung carcinoma and premalignant endobronchial lesions. (15892997)
2005
27
Asymptomatic lymphangitis carcinomatosis due to squamous cell lung carcinoma. (15832957)
2005
28
Duodenal metastases from squamous cell carcinoma of the lung: endoscopic management of bleeding and biliary and duodenal obstruction. (15599004)
2004
29
Olmsted syndrome with squamous cell carcinoma of extremities and adenocarcinoma of the lung: failure to detect loricrin gene mutation. (14721769)
2003
30
Molecular cloning, identification and analysis of lung squamous cell carcinoma-related genes. (12445744)
2002
31
Apoptosis in squamous cell carcinoma of the lung: correlation with survival and clinicopathological features. (11215278)
2001
32
Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma. (11522592)
2001
33
Narrowing of the region of allelic loss in 21q11-21 in squamous non- small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment. (10612803)
2000
34
The expression of cyclins D1 and E in predicting short-term survival in squamous cell carcinoma of the lung. (11106072)
2000
35
Basaloid squamous cell carcinoma of the vagina metastasizing to the lung. A case report. (11077635)
2000
36
Gene amplification at chromosome 1pter-p33 including the genes PAX7 and ENO1 in squamous cell lung carcinoma. (10853020)
2000
37
Detection of the p53 protein accumulation and p53 gene mutation in squamous cell carcinoma of the lung]. (11244963)
1998
38
Vascular endothelial growth factor expression in non-small-cell lung cancer: prognostic significance in squamous cell carcinoma. (9605068)
1998
39
Prognostic value of ERBB-1, VEGF, cyclin A, FOS, JUN and MYC in patients with squamous cell lung carcinomas. (9484827)
1998
40
Prognostic significance of p53 gene mutations in squamous cell carcinoma of the lung. (9683822)
1998
41
The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated elongation factor 2 gene. (9823325)
1998
42
Lung squamous cell carcinoma producing both parathyroid hormone-related peptide and granulocyte colony stimulating factor. (8809885)
1996
43
A comparison of serum CYFRA 21-1 and SCC Ag in the diagnosis of squamous cell lung carcinoma. (8882476)
1996
44
Glutathione S transferase Pi is a powerful indicator in chemotherapy of human lung squamous-cell carcinoma. (8578019)
1995
45
A case of hCG-alpha and beta complex producing lung squamous cell carcinoma associated with gynecomastia]. (7616092)
1995
46
Pseudovascular adenoid squamous cell carcinoma of the lung: clinicopathologic study of three cases and comparison with true pleuropulmonary angiosarcoma. (8163270)
1994
47
Patterns of p53 mutations in squamous cell carcinoma of the lung. Acquisition at a relatively early age. (7992847)
1994
48
A case of squamous cell lung carcinoma with high concentration of parathyroid hormone-related peptide in serum and pleural effusion presenting hypercalcemia. (8514608)
1993
49
Cytogenetic comparison of two poorly differentiated human lung squamous cell carcinoma lines. (1581877)
1992
50
A monoclonal antibody (Po66) directed against human lung squamous cell carcinoma immunolocalization of tumour xenografts in nude mice. (3297323)
1987

Genetic Variations for Lung Squamous Cell Carcinoma

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Expression for genes affiliated with Lung Squamous Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Squamous Cell Carcinoma

Search GEO for disease gene expression data for Lung Squamous Cell Carcinoma.

Pathways for genes affiliated with Lung Squamous Cell Carcinoma

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29KEGG, 51QIAGEN, 12EMD Millipore, 53Reactome
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Compounds for genes affiliated with Lung Squamous Cell Carcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2413.5S100A7, AREG, CLDN5, CLDN3, CLDN4, CLDN1
2ochratoxin a44 5911.2CLDN4, CLDN3

GO Terms for genes affiliated with Lung Squamous Cell Carcinoma

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16Gene Ontology
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Cellular components related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lateral plasma membraneGO:01632810.5CLDN1, CLDN7, CLDN4
2tight junctionGO:00592310.2CLDN1, CLDN7, CLDN4, CLDN3, CLDN5

Biological processes related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:01633810.5CLDN1, CLDN7, CLDN4, CLDN3, CLDN5

Molecular functions related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.5CLDN5, CLDN3, CLDN4, CLDN7, CLDN1, S100A2
2structural molecule activityGO:00519810.2CLDN1, CLDN7, CLDN4, CLDN3, CLDN5

Products for genes affiliated with Lung Squamous Cell Carcinoma

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Sources for Lung Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet