MCID: LNG039
MIFTS: 45

Lung Squamous Cell Carcinoma malady

Skin diseases, Respiratory diseases, Cancer diseases categories

Summaries for Lung Squamous Cell Carcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung... more...

MalaCards: Lung Squamous Cell Carcinoma, also known as squamous cell carcinoma of lung, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Lung Squamous Cell Carcinoma is TSPYL5 (TSPY-like 5), and among its related pathways are Leukocyte transendothelial migration and Integrin Pathway. The compounds calcium and ochratoxin a have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and endothelial.

Aliases & Classifications for Lung Squamous Cell Carcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Respiratory diseases


Aliases & Descriptions:

lung squamous cell carcinoma 8 10
squamous cell carcinoma of lung 8 60
epidermoid cell carcinoma of the lung 8
squamous cell lung cancer 44


External Ids:

Disease Ontology8 DOID:3907
SNOMED-CT56 254634000
NCIt39 C3493

Related Diseases for Lung Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Lung Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.9CLDN7, KLK10, S100A2, S100A7, AREG, SNAI2
2adenocarcinoma31.2S100A2, AREG, NAPSA, CLDN5, CLDN3, CLDN4
3lung cancer30.7NAPSA
4lung adenocarcinoma10.8
5small cell carcinoma10.5
6lung small cell carcinoma10.5
7bone carcinoma10.4
8parathyroid carcinoma10.3
9pulmonary alveolar proteinosis10.3
10lung lymphoma10.3
11large cell carcinoma10.3
12lung large cell carcinoma10.3
13acanthosis nigricans10.2
14burns10.2
15cortical thymoma10.2
16gastric lymphoma10.2
17nevoid basal cell carcinoma syndrome10.2
18colon squamous cell carcinoma10.2
19gastric squamous cell carcinoma10.2
20lung giant cell carcinoma10.2
21squamous papillomatosis10.2
22asbestos-related lung carcinoma10.2
23gynecomastia10.2
24hypercalcemia10.2
25adenosquamous carcinoma10.2
26adenosquamous cell lung carcinoma10.2
27breast adenocarcinoma10.2
28breast squamous cell carcinoma10.2
29cholangiocarcinoma10.2
30colon adenocarcinoma10.2
31gingivitis10.2
32intrahepatic cholangiocarcinoma10.2
33marginal zone b-cell lymphoma10.2
34pleurisy10.2
35renal cell carcinoma10.2
36skin squamous cell carcinoma10.2
37thymic carcinoma10.2
38thymoma10.2
39transitional cell carcinoma10.2
40pulmonary tuberculosis10.2
41neuronitis10.2
42acute myocardial infarction10.2
43cell type cancer10.2
44myelofibrosis10.2
45myocardial infarction10.2
46tuberculosis10.2
47vascular cancer10.2
48psoriasis10.0S100A2, S100A7, AREG
49stomach cancer10.0KLK10, AREG, CLDN3, CLDN4, CLDN7
50ovarian cystadenoma10.0CLDN4, AREG

Graphical network of the top 20 diseases related to Lung Squamous Cell Carcinoma:



Diseases related to lung squamous cell carcinoma

Clinical Features for Lung Squamous Cell Carcinoma

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Drugs & Therapeutics for Lung Squamous Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lung Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Lung Squamous Cell Carcinoma

Search NIH Clinical Center for Lung Squamous Cell Carcinoma

Search CenterWatch for Lung Squamous Cell Carcinoma

Genetic Tests for Lung Squamous Cell Carcinoma

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Anatomical Context for Lung Squamous Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Lung Squamous Cell Carcinoma:

32
Lung, Bone, Endothelial, Prostate, Colon, Brain, Lymph node, Breast, B cells, T cells, Cervix, Skin, Tongue, Thyroid, Small intestine, Bronchial epithelium

Animal Models for Lung Squamous Cell Carcinoma or affiliated genes

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Publications for Lung Squamous Cell Carcinoma

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50PubMed
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Articles related to Lung Squamous Cell Carcinoma:

(show top 50)    (show all 422)
idTitleAuthorsYear
1
GASC1 expression in lung carcinoma is associated with smoking and prognosis of squamous cell carcinoma. (24371038)
2013
2
Terminal N-Acetylgalactosamine-Specific Leguminous Lectin from Wisteria japonica as a Probe for Human Lung Squamous Cell Carcinoma. (24349556)
2013
3
Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. (23786770)
2013
4
Increased serum S-TRAIL level in newly diagnosed stage-IV lung adenocarcinoma but not squamous cell carcinoma is correlated with age and smoking. (24083751)
2013
5
Human blood plasma proteome mapping for search of potential markers of the lung squamous cell carcinoma. (24261084)
2013
6
Clinicopathological significance of combined analysis of cytokeratin19 expression and preoperative serum CYFRA21-1 levels in human lung squamous cell carcinoma. (23909079)
2013
7
Chemoprevention of lung squamous cell carcinoma by ginseng. (23550152)
2013
8
An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing. (24244370)
2013
9
Cathepsin B as a potential prognostic and therapeutic marker for human lung squamous cell carcinoma. (24139065)
2013
10
Lung squamous cell carcinoma combined with tuberculous pleurisy. (23075740)
2012
11
Mixed squamous and large-cell carcinoma of the lung: a case study and literature review. (23174733)
2012
12
Decreased Beclin-1 expression is correlated with the growth of the primary tumor in patients with squamous cell carcinoma and adenocarcinoma of the lung. (21777947)
2012
13
Laminin-5I^2 chain expression is associated with tumor cell invasiveness and prognosis of lung squamous cell carcinoma. (23124251)
2012
14
Prohibitin in squamous cell carcinoma of the lung: its expression and possible clinical significance. (22304787)
2012
15
The transcriptional consequences of somatic amplifications, deletions, and rearrangements in a human lung squamous cell carcinoma. (23226101)
2012
16
miR-205 Expression levels in nonsmall cell lung cancer do not always distinguish adenocarcinomas from squamous cell carcinomas. (21263248)
2011
17
Significance of epidermal growth factor receptor gene mutations in squamous cell lung carcinoma. (21318227)
2011
18
The clinical significance of Claudin-7 and slug expression in lung squamous cell carcinoma and adenocarcinoma]. (21645451)
2011
19
Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men. (22072123)
2010-2011
20
MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. (20838434)
2010
21
Hypercalcemia-leukocytosis syndrome in a patient with cavitating squamous cell carcinoma of the lung. (19183491)
2009
22
Triosephosphate isomerase and peroxiredoxin 6, two novel serum markers for human lung squamous cell carcinoma. (19737146)
2009
23
Desmocollin-3: a new marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung. (19287461)
2009
24
Angiogenic switching in the alveolar capillaries in primary lung adenocarcinoma and squamous cell carcinoma. (17965528)
2007
25
Identification and validation of S100A7 associated with lung squamous cell carcinoma metastasis to brain. (17418446)
2007
26
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung. (16195240)
2006
27
Increased expression of connexin 26 in the invasive component of lung squamous cell carcinoma: significant correlation with poor prognosis. (15882926)
2006
28
Differences in clinicopathological and biological features between central-type and peripheral-type squamous cell carcinoma of the lung. (16497410)
2006
29
Lung squamous cell carcinoma and adenocarcinoma cell lines use different mediators to induce comparable phenotypic and functional changes in human monocyte-derived dendritic cells. (16133109)
2006
30
Casein kinase II alpha subunit and C1-inhibitor are independent predictors of outcome in patients with squamous cell carcinoma of the lung. (15355908)
2004
31
Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers. (15150628)
2004
32
Cytosolic levels of neuron-specific enolase in squamous cell carcinomas of the lung. (14535589)
2003
33
Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung. (11895903)
2002
34
A p53 homologue and a novel serine proteinase inhibitor are over-expressed in lung squamous cell carcinoma. (11714533)
2001
35
Cloning and chromosomal localization of human WIG-1/PAG608 and demonstration of amplification with increased expression in primary squamous cell carcinoma of the lung. (11689294)
2001
36
Comparison of tumor suppressor gene deletion between squamous cell carcinoma and adenocarcinoma lung cancer in Chinese]. (11859712)
2001
37
Retinoic acid-mediated G1 arrest is associated with induction of p27(Kip1) and inhibition of cyclin-dependent kinase 3 in human lung squamous carcinoma CH27 cells. (10896783)
2000
38
Increased upstream methylation has no influence on the overexpression of the parathyroid hormone-related protein gene in squamous cell carcinoma of the lung. (11044652)
2000
39
CD40 and Bcl2 expression in squamous cell carcinoma of the lung: correlation with apoptosis, survival, and other clinicopathological factors. (10547598)
1999
40
Very young patient with peculiar squamous cell carcinoma of the lung. (10628938)
1999
41
Clinical implications of cyclins, cyclin-dependent kinases, RB and E2F1 in squamous-cell lung carcinoma. (9645354)
1998
42
Cytokeratin expression in squamous cell carcinoma of the lung and oral cavity: an immunohistochemical study with possible clinical relevance. (9574953)
1998
43
Renal failure, paraproteinemia, and lung squamous cell carcinoma. (9154668)
1997
44
Reversion of malignant phenotypes of human lung squamous carcinoma cells by ornithine decarboxylase antisense RNA]. (9206034)
1996
45
Lysosomal dipeptidyl-peptidases I and II in human squamous cell lung carcinoma and lung parenchyma. (8841504)
1996
46
A placebo-controlled randomized double-blind study of adjuvant intrapleural BCG in patients with resected T1N0, T1N1, or T2N0 squamous cell carcinoma, adenocarcinoma, or large cell carcinoma of the lung. LCSG Protocol 771. (7988246)
1994
47
Epidermal growth factor receptor expression in squamous cell lung carcinomas: an immunohistochemical and gene analysis in formalin-fixed, paraffin-embedded material. (8236825)
1993
48
The GSTM1 null genotype as a potential risk modifier for squamous cell carcinoma of the lung. (8330369)
1993
49
Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus. (2208001)
1990
50
Establishment and characterization of a continuous lung squamous cell carcinoma cell line (U-1752). (6178358)
1981

Genetic Variations for Lung Squamous Cell Carcinoma

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Expression for genes affiliated with Lung Squamous Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Squamous Cell Carcinoma

Search GEO for disease gene expression data for Lung Squamous Cell Carcinoma.

Pathways for genes affiliated with Lung Squamous Cell Carcinoma

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29KEGG, 51QIAGEN, 12EMD Millipore, 53Reactome
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Compounds for genes affiliated with Lung Squamous Cell Carcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2413.5S100A7, AREG, CLDN5, CLDN3, CLDN4, CLDN1
2ochratoxin a44 5911.2CLDN4, CLDN3

GO Terms for genes affiliated with Lung Squamous Cell Carcinoma

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16Gene Ontology
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Cellular components related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lateral plasma membraneGO:01632810.5CLDN1, CLDN7, CLDN4
2tight junctionGO:00592310.2CLDN1, CLDN7, CLDN4, CLDN3, CLDN5

Biological processes related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:01633810.5CLDN1, CLDN7, CLDN4, CLDN3, CLDN5

Molecular functions related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.5CLDN5, CLDN3, CLDN4, CLDN7, CLDN1, S100A2
2structural molecule activityGO:00519810.2CLDN1, CLDN7, CLDN4, CLDN3, CLDN5

Products for genes affiliated with Lung Squamous Cell Carcinoma

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Sources for Lung Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet