MCID: LNG039
MIFTS: 37

Lung Squamous Cell Carcinoma malady

Summaries for Lung Squamous Cell Carcinoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung... more...

MalaCards: Lung Squamous Cell Carcinoma, also known as squamous cell carcinoma of lung, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Lung Squamous Cell Carcinoma is TSPYL5 (TSPY-like 5), and among its related pathways are Leukocyte transendothelial migration and Integrin Pathway. The compounds calcium and ochratoxin a have been mentioned in the context of this disorder.

Aliases & Classifications for Lung Squamous Cell Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

lung squamous cell carcinoma 8 10
squamous cell carcinoma of lung 8 61
epidermoid cell carcinoma of the lung 8
squamous cell lung cancer 45


External Ids:

Disease Ontology8 DOID:3907
SNOMED-CT57 254634000
NCIt40 C3493

Related Diseases for Lung Squamous Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lung Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.9CLDN7, KLK10, S100A2, S100A7, AREG, SNAI2
2adenocarcinoma31.2S100A2, AREG, NAPSA, CLDN5, CLDN3, CLDN4
3anal squamous cell carcinoma10.7
4small cell carcinoma10.5
5bone carcinoma10.4
6parathyroid carcinoma10.3
7pulmonary alveolar proteinosis10.3
8lung lymphoma10.3
9colon squamous cell carcinoma10.3
10large cell carcinoma10.3
11acanthosis nigricans10.2
12pulmonary tuberculosis10.2
13acute myocardial infarction10.2
14tuberculosis10.2
15vascular cancer10.2
16squamous cell papilloma10.2
17cortical thymoma10.2
18gastric lymphoma10.2
19gastric squamous cell carcinoma10.2
20lung giant cell carcinoma10.2
21squamous papillomatosis10.2
22burkitt's lymphoma10.2
23asbestos-related lung carcinoma10.2
24gynecomastia10.2
25hypercalcemia10.2
26adenosquamous carcinoma10.2
27adenosquamous cell lung carcinoma10.2
28breast adenocarcinoma10.2
29skin squamous cell carcinoma10.2
30thymic carcinoma10.2
31thymoma10.2
32type c thymoma10.2
33vulva squamous cell carcinoma10.2
34recurrent respiratory papillomatosis10.2
35psoriasis10.0S100A2, S100A7, AREG
36stomach cancer10.0KLK10, AREG, CLDN3, CLDN4, CLDN7
37ovarian cystadenoma10.0CLDN4, AREG
38ovarian cancer10.0CLDN4, CLDN3, SNAI2, AREG, KLK10
39lung cancer10.0NAPSA
40papillary carcinoma10.0S100A2, CLDN3, CLDN4
41cystadenoma10.0AREG
42gastric adenocarcinoma10.0CLDN3, CLDN4, CLDN7
43ductal carcinoma in situ10.0S100A7
44glioblastoma multiforme10.0AREG
45perineurioma10.0CLDN1, CLDN7
46breast cancer10.0KLK10, S100A2, S100A7, AREG, SNAI2, CLDN3
47colorectal cancer10.0AREG
48endometrial carcinoma10.0AREG, CLDN3, CLDN4
49prostate cancer10.0CLDN4, CLDN3, AREG, S100A2, KLK10

Graphical network of the top 20 diseases related to Lung Squamous Cell Carcinoma:



Diseases related to lung squamous cell carcinoma

Clinical Features for Lung Squamous Cell Carcinoma

Drugs & Therapeutics for Lung Squamous Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Lung Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Lung Squamous Cell Carcinoma

Search NIH Clinical Center for Lung Squamous Cell Carcinoma

Search CenterWatch for Lung Squamous Cell Carcinoma

Genetic Tests for Lung Squamous Cell Carcinoma

Anatomical Context for Lung Squamous Cell Carcinoma

Animal Models for Lung Squamous Cell Carcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Lung Squamous Cell Carcinoma

Sources:
51PubMed
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Articles related to Lung Squamous Cell Carcinoma:

(show top 50)    (show all 423)
idTitleAuthorsYear
1
How Sensitive Are Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors for Squamous Cell Carcinoma of the Lung Harboring EGFR Gene-Sensitive Mutations? (24419431)
2014
2
Polymorphism Arg72Pro of p53 confers susceptibility to squamous cell carcinoma of lungs in a North Indian population. (23317414)
2013
3
Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma. (23759980)
2013
4
Proteomic profiling of serum from stage I lung squamous cell carcinoma patients. (23725126)
2013
5
Double primary cancers: intrahepatic cholangiocarcinoma with myocardial metastases and lung squamous cell carcinoma. (22975543)
2012
6
A word of caution regarding napsin A expression in squamous cell carcinomas of the lung. (22198009)
2012
7
hMSH2 and hMLH1 gene expression patterns differ between lung adenocarcinoma and squamous cell carcinoma: correlation with patient survival and response to adjuvant chemotherapy treatment. (22865300)
2012
8
Analysis on the clinical features of 22 basaloid squamous cell carcinoma of the lung. (21269455)
2011
9
Clinical Phase I study with an Insulin-like Growth Factor-1 receptor inhibitor: experiences in patients with squamous non-small cell lung carcinoma. (20698809)
2011
10
Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma. (20668658)
2010
11
The role of microRNA in human lung squamous cell carcinoma. (20620595)
2010
12
Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung. (20980808)
2010
13
Ginsenoside Rg3 induces apoptosis of human lung squamous cell carcinoma SK-MES-1 cell line]. (19778801)
2009
14
Expression of the WT1 gene -KTS domain isoforms suppresses the invasive ability of human lung squamous cell carcinoma cells. (18202757)
2008
15
Disruption of the non-canonical WNT pathway in lung squamous cell carcinoma. (20401333)
2008
16
Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma. (17541031)
2007
17
Squamous cellular carcinoma immunocomplexed is increased in scleroderma patients with lung fibrosis. (18078639)
2007
18
Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung. (17290396)
2007
19
A case of squamous cell carcinoma of the lung with a high titer of proteinase 3 antineutrophil cytoplasmic antibody]. (17228809)
2006
20
Paraneoplastic polymyositis associated with squamous cell carcinoma of the lung. (16778295)
2006
21
Proteomics analysis of stage-specific proteins expressed in human squamous cell lung carcinoma tissues. (17192052)
2005
22
Nuclear galectin-3 expression is an independent predictive factor of recurrence for adenocarcinoma and squamous cell carcinoma of the lung. (15832191)
2005
23
The functional polymorphism in the matrix metalloproteinase-7 promoter increases susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma. (15930031)
2005
24
Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells. (16203784)
2005
25
Difference of caveolin-1 expression pattern in human lung neoplastic tissue. Atypical adenomatous hyperplasia, adenocarcinoma and squamous cell carcinoma. (15331180)
2004
26
Preliminary research of the relationship between overexpression of facilitative glucose transporter-1 and fluorodeoxyglucose uptake in primary human lung squamous cell carcinoma]. (14728832)
2003
27
p16 protein expression is associated with a poor prognosis in squamous cell carcinoma of the lung. (10646891)
2000
28
Expression of thrombomodulin in squamous cell carcinoma of the lung: its relationship to lymph node metastasis and prognosis of the patients. (10737713)
2000
29
Tissue polypeptide specific antigen and squamous cell carcinoma antigen for early prediction of recurrence in lung squamous cell carcinoma. (10773133)
2000
30
Morphologic and molecular-genetic characteristics of keratinization and apoptosis in squamous cell lung carcinoma]. (10897431)
2000
31
Expression analysis of genes at 3q26-q27 involved in frequent amplification in squamous cell lung carcinoma. (10492640)
1999
32
Inverse correlation between apoptotic (Fas ligand, caspase-3) and angiogenic factors (VEGF, microvessel density) in squamous cell lung carcinomas. (10470099)
1999
33
Evidence for mRNA expression of vascular endothelial growth factor by X-ray irradiation in a lung squamous carcinoma cell line. (10397456)
1998
34
A case of squamous cell carcinoma of the lung associated with exophthalmos and hypercalcemia]. (9492473)
1998
35
Purification of a tumoral marker recognized by monoclonal antibody Po66 and associated with human lung squamous cell carcinoma. (8915709)
1996
36
Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population. (7586131)
1995
37
Squamous cell carcinoma of the lung: does the nm23 gene expression correlate to the tumor stage? (7863493)
1994
38
Expression of type IV collagen and its degrading enzymes in squamous cell carcinoma of lung. (7961122)
1994
39
Quantitative analysis of carcinoembryonic antigen, squamous cell carcinoma antigen, CA 125, and CA 50 cytosolic content in non-small cell lung cancer. (8168034)
1994
40
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung. (7513612)
1994
41
High levels of nm23-H1 and nm23-H2 messenger RNA in human squamous-cell lung carcinoma are associated with poor differentiation and advanced tumor stages. (8375920)
1993
42
Association and dissociation of a protease and its inhibitor on the surface of lung squamous cell carcinoma cells. (8352526)
1993
43
Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids. (1450447)
1992
44
Immunoscintigraphy of human lung squamous cell carcinoma using an iodine-131 labelled monoclonal antibody (Po66). (2310675)
1990
45
Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung. (2567993)
1989
46
Negative phase II trial of menogaril in advanced squamous, adeno- and large cell carcinoma of the lung. (2833403)
1988
47
Generation of monoclonal antibodies against human lung squamous cell carcinoma and adenocarcinoma using mice rendered tolerant to normal human lung. (3731100)
1986
48
Adenoid squamous cell carcinoma of the penis. Report of a surgical case clinically manifested with rapid lung metastasis. (6670557)
1983
49
Receptors for peanut agglutinin isolated from cell lines of human Burkitt lymphoma, lung squamous cell carcinoma and gastric signet ring cell carcinoma. (6295867)
1982
50
Mechlorethamine (NSC-762) plus CCNU (NSC-79037) in the treatment of inoperable squamous and large cell carcinoma of the lung. (186183)
1976

Genetic Variations for Lung Squamous Cell Carcinoma

Expression for genes affiliated with Lung Squamous Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Squamous Cell Carcinoma

Search GEO for disease gene expression data for Lung Squamous Cell Carcinoma.

Pathways for genes affiliated with Lung Squamous Cell Carcinoma

Sources:
30KEGG, 52QIAGEN, 12EMD Millipore, 54Reactome
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Compounds for genes affiliated with Lung Squamous Cell Carcinoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience
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Compounds related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2413.5S100A7, AREG, CLDN5, CLDN3, CLDN4, CLDN1
2ochratoxin a45 6011.2CLDN4, CLDN3

GO Terms for genes affiliated with Lung Squamous Cell Carcinoma

Sources:
16Gene Ontology
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Cellular components related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lateral plasma membraneGO:01632810.5CLDN1, CLDN7, CLDN4
2tight junctionGO:00592310.2CLDN1, CLDN7, CLDN4, CLDN3, CLDN5

Biological processes related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:01633810.5CLDN1, CLDN7, CLDN4, CLDN3, CLDN5

Molecular functions related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.5CLDN5, CLDN3, CLDN4, CLDN7, CLDN1, S100A2
2structural molecule activityGO:00519810.2CLDN1, CLDN7, CLDN4, CLDN3, CLDN5

Products for genes affiliated with Lung Squamous Cell Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lung Squamous Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet