MCID: LNG039
MIFTS: 45

Lung Squamous Cell Carcinoma malady

Skin diseases, Respiratory diseases, Cancer diseases categories

Summaries for Lung Squamous Cell Carcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung... more...

MalaCards: Lung Squamous Cell Carcinoma, also known as squamous cell carcinoma of lung, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Lung Squamous Cell Carcinoma is TSPYL5 (TSPY-like 5), and among its related pathways are Leukocyte transendothelial migration and Integrin Pathway. The compounds calcium and ochratoxin a have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and endothelial.

Aliases & Classifications for Lung Squamous Cell Carcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Respiratory diseases


Aliases & Descriptions:

lung squamous cell carcinoma 8 10
squamous cell carcinoma of lung 8 60
epidermoid cell carcinoma of the lung 8
squamous cell lung cancer 44


External Ids:

Disease Ontology8 DOID:3907
SNOMED-CT56 254634000
NCIt39 C3493

Related Diseases for Lung Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Lung Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.9CLDN7, KLK10, S100A2, S100A7, AREG, SNAI2
2adenocarcinoma31.2S100A2, AREG, NAPSA, CLDN5, CLDN3, CLDN4
3lung cancer30.7NAPSA
4lung adenocarcinoma10.8
5small cell carcinoma10.5
6lung small cell carcinoma10.5
7bone carcinoma10.4
8parathyroid carcinoma10.3
9pulmonary alveolar proteinosis10.3
10lung lymphoma10.3
11large cell carcinoma10.3
12lung large cell carcinoma10.3
13acanthosis nigricans10.2
14burns10.2
15cortical thymoma10.2
16gastric lymphoma10.2
17nevoid basal cell carcinoma syndrome10.2
18colon squamous cell carcinoma10.2
19gastric squamous cell carcinoma10.2
20lung giant cell carcinoma10.2
21squamous papillomatosis10.2
22asbestos-related lung carcinoma10.2
23gynecomastia10.2
24hypercalcemia10.2
25adenosquamous carcinoma10.2
26adenosquamous cell lung carcinoma10.2
27breast adenocarcinoma10.2
28breast squamous cell carcinoma10.2
29cholangiocarcinoma10.2
30colon adenocarcinoma10.2
31gingivitis10.2
32intrahepatic cholangiocarcinoma10.2
33marginal zone b-cell lymphoma10.2
34pleurisy10.2
35renal cell carcinoma10.2
36skin squamous cell carcinoma10.2
37thymic carcinoma10.2
38thymoma10.2
39transitional cell carcinoma10.2
40pulmonary tuberculosis10.2
41neuronitis10.2
42acute myocardial infarction10.2
43cell type cancer10.2
44myelofibrosis10.2
45myocardial infarction10.2
46tuberculosis10.2
47vascular cancer10.2
48psoriasis10.0S100A2, S100A7, AREG
49stomach cancer10.0KLK10, AREG, CLDN3, CLDN4, CLDN7
50ovarian cystadenoma10.0CLDN4, AREG

Graphical network of the top 20 diseases related to Lung Squamous Cell Carcinoma:



Diseases related to lung squamous cell carcinoma

Clinical Features for Lung Squamous Cell Carcinoma

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Drugs & Therapeutics for Lung Squamous Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lung Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Lung Squamous Cell Carcinoma

Search NIH Clinical Center for Lung Squamous Cell Carcinoma

Search CenterWatch for Lung Squamous Cell Carcinoma

Genetic Tests for Lung Squamous Cell Carcinoma

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Anatomical Context for Lung Squamous Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Lung Squamous Cell Carcinoma:

32
Lung, Bone, Endothelial, Prostate, Colon, Breast, Lymph node, Brain, Small intestine, B cells, T cells, Skin, Thyroid, Tongue, Cervix, Bronchial epithelium

Animal Models for Lung Squamous Cell Carcinoma or affiliated genes

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Publications for Lung Squamous Cell Carcinoma

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50PubMed
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Articles related to Lung Squamous Cell Carcinoma:

(show top 50)    (show all 422)
idTitleAuthorsYear
1
Identification of a Subset of Human Non-Small Cell Lung Cancer Patients with High PI3KI^ and Low PTEN Expression, More Prevalent in Squamous Cell Carcinoma. (24284056)
2014
2
Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion. (24171005)
2013
3
Bone marrow-derived cells contribute to NDEA-induced lung squamous cell carcinoma. (23055190)
2013
4
Tumor cell expression of vascular endothelial growth factor receptor 2 is an adverse prognostic factor in patients with squamous cell carcinoma of the lung. (24244672)
2013
5
Treatment-related toxicities in a phase II trial of dasatinib in patients with squamous cell carcinoma of the lung. (24128713)
2013
6
Folate receptor in adenocarcinoma and squamous cell carcinoma of the lung: potential target for folate-linked therapeutic agents. (22984810)
2013
7
Myristoylated alanine-rich C-kinase substrate as a prognostic biomarker in human primary lung squamous cell carcinoma. (24240590)
2013
8
Podoplanin-positive cancer-associated fibroblasts could have prognostic value independent of cancer cell phenotype in stage I lung squamous cell carcinoma: usefulness of combining analysis of both cancer cell phenotype and cancer-associated fibroblast phenotype. (23081722)
2013
9
The role of PTPN13 in invasion and metastasis of lung squamous cell carcinoma. (23906871)
2013
10
The evaluation of immunohistochemical markers and thymic cortical microenvironmental cells in distinguishing thymic carcinoma from type b3 thymoma or lung squamous cell carcinoma. (23801129)
2013
11
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. (22006338)
2011
12
ALK translocation in non-small cell lung cancer with adenocarcinoma and squamous cell carcinoma markers. (21847065)
2011
13
Immunolocalization of glycodelin in human adenocarcinoma of the lung, squamous cell carcinoma of the lung and lung metastases of colonic adenocarcinoma. (21168900)
2011
14
A 5-microRNA signature for lung squamous cell carcinoma diagnosis and hsa-miR-31 for prognosis. (21890451)
2011
15
The expression of PEBP4 protein in lung squamous cell carcinoma. (21887552)
2011
16
Lung squamous cell carcinoma mRNA expression subtypes are reproducible, clinically important, and correspond to normal cell types. (20643781)
2010
17
Identification of proteomic differences between squamous cell carcinoma of the lung and bronchial epithelium. (19176476)
2009
18
Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma. (19273703)
2009
19
Epidermal growth factor receptor mutations and the clinical outcome in male smokers with squamous cell carcinoma of lung. (19543508)
2009
20
Metastatic potential of lung squamous cell carcinoma associated with HSPC300 through its interaction with WAVE2. (19576655)
2009
21
Three-gene expression signature predicts survival in early-stage squamous cell carcinoma of the lung. (18676750)
2008
22
Minimal deletion regions in lung squamous cell carcinoma: association with abnormality of the DNA double-strand break repair genes and their applications on gene identification and prognostic biomarkers. (17931740)
2008
23
Selective expression of S100A7 in lung squamous cell carcinomas and large cell carcinomas but not in adenocarcinomas and small cell carcinomas. (18364444)
2008
24
Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas. (17585317)
2007
25
Abnormalities of epidermal growth factor receptor in lung squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas: tyrosine kinase domain mutations are not rare in tumors with an adenocarcinoma component. (17238183)
2007
26
Probably anti-Tr associated paraneoplastic cerebellar degeneration as initial presentation of a squamous cell carcinoma of the lung. (16644410)
2006
27
COX-2 expression during early lung squamous cell carcinoma oncogenesis. (16055866)
2005
28
Expression of PKB protein in human squamous-cell carcinoma and adenocarcinoma of lung]. (15946565)
2005
29
Enhanced expression of Aggrus (T1alpha/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma. (16006773)
2005
30
Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma. (16022908)
2005
31
Squamous cell carcinoma of the lung producing granulocyte colony-stimulating factor and resembling a malignant pleural mesothelioma. (15005252)
2004
32
Stevens-Johnson syndrome induced by paclitaxel in a patient with squamous cell carcinoma of the lung: a case report. (15154637)
2004
33
Paraneoplastic cerebellar degeneration (PCD) associated with squamous cell carcinoma of the lung. (15335190)
2004
34
Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization. (15246564)
2004
35
Comparison of p53 mutations between adenocarcinoma and squamous cell carcinoma of the lung: unique spectra involving G to A transitions and G to T transversions in both histologic types. (12711114)
2003
36
Genetic polymorphism in myeloperoxidase but not GSTM1 is associated with risk of lung squamous cell carcinoma in a Chinese population. (12397651)
2002
37
High levels of cytokeratin 19 fragments but no evidence of cytokeratins 1, 2, 10/11, 14 or filaggrin in the serum of squamous cell lung carcinoma patients. (11054023)
2001
38
Utility of the serum tumor markers: CYFRA 21.1, carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCC) in squamous cell lung cancer. (11277326)
2000
39
Cytokeratin fragment 19 and squamous cell carcinoma antigen for early prediction of recurrence of squamous cell lung carcinoma. (10857885)
2000
40
Pulmonary alveolar proteinosis with lung squamous cell carcinoma. (10464867)
1999
41
Immunochemical analysis of cathepsin B in lung tumours: an independent prognostic factor for squamous cell carcinoma patients. (10507778)
1999
42
Increased NM23: MTS1 ratio inversely correlated with metastasis behaviour in human lung squamous cell carcinoma. (9066685)
1997
43
Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype. (7718322)
1995
44
DNA aberrations at the retinoblastoma gene locus in human squamous cell carcinomas of the lung. (8302602)
1994
45
Establishment of a human lung squamous cell carcinoma cell line LK-17, and characterization of procoagulant, platelet aggregation and metastatic potential]. (8297820)
1993
46
Expression of topoisomerase II, catalase, metallothionein and thymidylate-synthase in human squamous cell lung carcinomas and their correlation with doxorubicin resistance and with patients' smoking habits. (1330347)
1992
47
Prognostic value of c-erbB-2 protein expression in human lung adenocarcinoma and squamous cell carcinoma. (1683776)
1991
48
Evaluation of squamous cell carcinoma antigen as a new marker for lung cancer. (2311066)
1990
49
Phase II trial of epirubicin in advanced squamous, adeno- and large cell carcinoma of the lung. (6327315)
1984
50
Hexamethylmelamine, bleomycin, and CCNU chemotherapy for patients with squamous cell carcinoma, large cell carcinoma, and adenocarcinoma of the lung unresponsive to cyclophosphamide, adriamycin, methotrexate, and procarbazine. (77725)
1978

Genetic Variations for Lung Squamous Cell Carcinoma

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Expression for genes affiliated with Lung Squamous Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lung Squamous Cell Carcinoma

Search GEO for disease gene expression data for Lung Squamous Cell Carcinoma.

Pathways for genes affiliated with Lung Squamous Cell Carcinoma

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29KEGG, 51QIAGEN, 12EMD Millipore, 53Reactome
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Compounds for genes affiliated with Lung Squamous Cell Carcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2413.5S100A7, AREG, CLDN5, CLDN3, CLDN4, CLDN1
2ochratoxin a44 5911.2CLDN4, CLDN3

GO Terms for genes affiliated with Lung Squamous Cell Carcinoma

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16Gene Ontology
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Cellular components related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lateral plasma membraneGO:01632810.5CLDN1, CLDN7, CLDN4
2tight junctionGO:00592310.2CLDN1, CLDN7, CLDN4, CLDN3, CLDN5

Biological processes related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:01633810.5CLDN1, CLDN7, CLDN4, CLDN3, CLDN5

Molecular functions related to Lung Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.5CLDN5, CLDN3, CLDN4, CLDN7, CLDN1, S100A2
2structural molecule activityGO:00519810.2CLDN1, CLDN7, CLDN4, CLDN3, CLDN5

Products for genes affiliated with Lung Squamous Cell Carcinoma

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Sources for Lung Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet