SLE
MCID: LPS004
MIFTS: 65

Lupus Erythematosus (SLE) malady

Skin category

Summaries for Lupus Erythematosus

Sources:
43NIH Rare Diseases, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 If you have lupus, your immune system attacks healthy cells and tissues by mistake. this can damage your joints, skin, blood vessels and organs. there are many kinds of lupus. the most common type, systemic lupus erythematosus, affects many parts of the body. discoid lupus causes a rash that doesn't go away. subacute cutaneous lupus causes sores after being out in the sun. another type can be caused by medication. neonatal lupus, which is rare, affects newborns. anyone can get lupus, but women are most at risk. lupus is also more common in african american, hispanic, asian and native american women. the cause of lupus is not known. lupus has many symptoms. some common ones are joint pain or swelling muscle pain fever with no known cause fatigue red rashes, often on the face (also called the "butterfly rash") there is no one test to diagnose lupus, and it may take months or years to make the diagnosis. there is no cure for lupus, but medicines and lifestyle changes can help control it. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Lupus Erythematosus, also known as lupus, is related to systemic lupus erythematosus and subacute cutaneous lupus erythematosus. An important gene associated with Lupus Erythematosus is TRIM21 (tripartite motif containing 21), and among its related pathways are Alcoholism and Immune System. The drugs chloroquine and chloroquine phosphate and the compounds calcium and tyrosine have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and homeostasis/metabolism.

NIH Rare Diseases:43 Lupus is an autoimmune disease. it can affect almost every organ in the body. symptoms of lupus can be very mild to life threatening. there are three types of lupus; systemic lupus erythematosus, discoid lupus, and drug-induced lupus. treatment of lupus depends on the severity of the condition and what parts of the body are affected. treatment may include acetaminophen, ibuprofen, antimalarial drugs, anti-inflammatory steroids, and/or immunosuppressive drugs. last updated: 3/11/2010

CDC:3 Systemic Lupus Erythematosus is an autoimmune disease in which the immune system produces antibodies to cells within the body leading to widespread inflammation and tissue damage. The causes of SLE are unknown but are believed to be linked to genetic, environmental, and hormonal factors. SLE may be characterized by periods of illness and remissions. SLE has a variety of clinical manifestations and can affect joints, skin, brain, lungs, kidneys, and blood vessels. People with SLE may experience fatigue, pain or swelling in joints, skin rashes, and fevers. A team approach in treating lupus is often warranted due to the number of organ systems involved.

Wikipedia:64 Lupus erythematosus is a name given to a collection of autoimmune diseases, in which the human immune... more...

Aliases & Classifications for Lupus Erythematosus

Sources:
43NIH Rare Diseases, 8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 34MedlinePlus, 57SNOMED-CT, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

lupus erythematosus 8 43 10 45 61
lupus 8 43 34
subacute cutaneous lupus 43 61
disseminated lupus erythematosus 43
lupus erythematosus, discoid 61
lupus erythematosus nos 8
discoid lupus 43
sle 43


External Ids:

Disease Ontology8 DOID:8857
ICD9CM27 695.4
NCIt40 C27153
ICD1025 L93, L93.0

Related Diseases for Lupus Erythematosus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the systemic lupus erythematosus family:

lupus erythematosus cr2-related susceptibility to systemic lupus erythematosus
systemic lupus erythematosus 14 systemic lupus erythematosus 9
systemic lupus erythematosus 1 systemic lupus erythematosus with nephritis 2
systemic lupus erythematosus 2 systemic lupus erythematosus 16
systemic lupus erythematosus 3 systemic lupus erythematosus 13
systemic lupus erythematosus 10 systemic lupus erythematosus 12
systemic lupus erythematosus with nephritis 1 systemic lupus erythematosus with nephritis 3
systemic lupus erythematosus with hemolytic anemia systemic lupus erythematosus 4
systemic lupus erythematosus 5 systemic lupus erythematosus 7
systemic lupus erythematosus 8

Diseases related to Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 816)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus32.7DNASE1, FCGR2B
2subacute cutaneous lupus erythematosus31.8TRIM21, CALR
3arthritis31.7C3, FCGR3A, FCGR2B, CR1, CTLA4, PTPN22
4lupus nephritis31.4CR1, FCGR3A, DNASE1
5nephritis31.4CR1, FCGR3A, C4A, C3
6vasculitis31.3CTLA4, C3, TRIM21
7systemic scleroderma31.1CTLA4, PTPN22, SSB
8congenital heart block31.0CALR, SSB, TRIM21
9thrombocytopenia31.0FCGR2B, FCGR3A
10rheumatic disease30.9TRIM21, CR1, CTLA4, CALR
11tuberculosis30.9CALR, DNASE1, CR1, C3
12hepatitis c30.8CALR, CTLA4, CR1
13sjogren's syndrome30.8TRIM21, SSB, CR1, FASLG, CALR
14vitiligo30.7PTPN22, C4B, CTLA4
15thyroiditis30.7FASLG, CTLA4, PTPN22
16hepatitis b30.5CR1, DNASE1
17acute myocardial infarction30.5DNASE1
18celiac disease30.4CALR, PTPN22, CTLA4
19hereditary angioedema30.4C4B, CR1
20sepsis30.3CR1, C4A, TLR5, C3, FCGR3A
21asthma30.3DNASE1, CTLA4, CR1, STAT4
22autoimmune thyroiditis30.3PTPN22, FASLG, CTLA4
23graves' disease30.2PTPN22, FASLG, FCRL3, CTLA4
24uveitis30.2CTLA4
25wegener's granulomatosis30.2CTLA4
26cystic fibrosis30.0CR1, DNASE1
27chagas disease30.0CALR
28burkitt's lymphoma30.0FASLG, FCGR2B, CR2
29common variable immune deficiency29.5TNFRSF13C
30cutaneous lupus erythematosus11.4
31discoid lupus erythematosus11.4
32pediatric systemic lupus erythematosus11.0
33antiphospholipid syndrome11.0
34drug-induced lupus erythematosus10.9
35lupus erythematosus panniculitis10.9
36systemic lupus erythematosus 110.9
37bullous systemic lupus erythematosus10.9
38n syndrome10.9
39myelitis10.8
40lupus erythematosus tumidus10.8
41atherosclerosis10.8
42protein-losing enteropathy10.8
43mixed connective tissue disease10.8
44squamous cell carcinoma10.8
45transverse myelitis10.7
46systemic lupus erythematosus 210.7
47hepatitis e10.7
48chilblain lupus10.7
49klinefelter's syndrome10.6
50alopecia10.6

Graphical network of the top 20 diseases related to Lupus Erythematosus:



Diseases related to lupus erythematosus

Clinical Features for Lupus Erythematosus

Drugs & Therapeutics for Lupus Erythematosus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lupus Erythematosus

Drug clinical trials:

Search ClinicalTrials for Lupus Erythematosus

Search NIH Clinical Center for Lupus Erythematosus

Search CenterWatch for Lupus Erythematosus

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Lupus Erythematosus

Anatomical Context for Lupus Erythematosus

Animal Models for Lupus Erythematosus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Lupus Erythematosus

Sources:
51PubMed
See all sources

Articles related to Lupus Erythematosus:

(show top 50)    (show all 5738)
idTitleAuthorsYear
1
Patient-reported fatigue and its impact on patients with systemic lupus erythematosus. (24197552)
2014
2
Lymphopenia as risk factor for development of severe infections in patients with systemic lupus erythematosus: a case-control study. (23458779)
2013
3
Highlighting the important effect of systemic lupus erythematosus on platelet count of critically ill patients. (23860807)
2013
4
Retinal artery embolization complicating Libman-Sacks endocarditis in a systemic lupus erythematosus patient. (23523393)
2013
5
Correction: Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus. (24223096)
2013
6
Hemophagocytic syndrome as the initial manifestation of systemic lupus erythematosus. (24316336)
2013
7
Angiotensin-converting enzyme (ACE) serum levels and gene polymorphism in Egyptian patients with systemic lupus erythematosus. (21976404)
2012
8
Herpes zoster in systemic lupus erythematosus. (22653627)
2012
9
Squamous cell carcinoma complicating discoid lupus erythematosus in Chinese patients: review of the literature, 1964-2010. (22421120)
2012
10
Assessment of serum vascular endothelial growth factor and nail fold capillaroscopy changes in systemic lupus erythematosus with and without cutaneous manifestations. (21950586)
2012
11
Bullous systemic lupus erythematosus. (21720069)
2011
12
C1q and anti-C1q antibody levels are correlated with disease severity in Chinese pediatric systemic lupus erythematosus. (20033414)
2011
13
A new model of induced experimental systemic lupus erythematosus (SLE) in pigs and its amelioration by treatment with a tolerogenic peptide. (19756988)
2010
14
Cardiac tamponade as a first manifestation of possible systemic lupus erythematosus in a 3-year-old female child. (20467385)
2010
15
Congenital lupus erythematosus presenting at birth with widespread erosions, pancytopenia, and subsequent hepatobiliary disease. (20199433)
2010
16
Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE). (19997561)
2009
17
HLA in Portuguese systemic lupus erythematosus patients and their relation to clinical features. (19758202)
2009
18
Analysis of C1q polymorphisms suggests association with systemic lupus erythematosus, serum C1q and CH50 levels and disease severity. (18504288)
2009
19
Therapy Insight: cardiovascular disease in pediatric systemic lupus erythematosus. (18349862)
2008
20
Contribution of the R620W polymorphism of protein tyrosine phosphatase non-receptor 22 to systemic lupus erythematosus in Poland. (19210878)
2008
21
Autoantibodies and neuropsychiatric events at the time of systemic lupus erythematosus diagnosis: results from an international inception cohort study. (18311802)
2008
22
Purpura fulminans in systemic lupus erythematosus. (18380706)
2008
23
Anti-SSA/Ro antibody as a risk factor for fluorouracil-induced drug eruptions showing acral erythema and discoid-lupus-erythematosus-like lesions. (17191054)
2007
24
Peripheral vascular disease in systemic lupus erythematosus. (17728365)
2007
25
Transforming growth factor beta 1 gene polymorphism in Japanese patients with systemic lupus erythematosus. (17579298)
2007
26
Development of the CLASI as an outcome instrument for cutaneous lupus erythematosus. (17537137)
2007
27
Treatment of refractory subacute cutaneous lupus erythematosus with efalizumab. (16635677)
2006
28
B-lymphocyte activating factor in systemic lupus erythematosus and rheumatoid arthritis in relation to autoantibody levels, disease measures and time. (17080911)
2006
29
Stevens-Johnson syndrome induced by mizoribine in a patient with systemic lupus erythematosus. (16633933)
2006
30
Systemic lupus erythematosus: all roads lead to type I interferons. (17011763)
2006
31
Single nucleotide polymorphisms of deoxyribonuclease I and their expression in Chinese systemic lupus erythematosus patients. (15569484)
2004
32
Antibodies to anionic phospholipids and anti-beta2-GPI: association with thrombosis and thrombocytopenia in systemic lupus erythematosus. (12559629)
2003
33
Mucosal involvement in childhood discoid lupus erythematosus. (14761153)
2003
34
Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus. (12847689)
2003
35
Comparison of anti 60 and 52 kDa SS-A/Ro antibodies in the pathogenesis of cutaneous lupus erythematosus. (12007719)
2002
36
Analysis of anti-prolactin autoantibodies in systemic lupus erythematosus. (11721703)
2001
37
Kikuchi-Fujimoto necrotizing lymphadenitis associated with cutaneous lupus erythematosus: a case report. (10949458)
2000
38
Association of the interferon-gamma receptor variant (Val14Met) with systemic lupus erythematosus. (10079289)
1999
39
Bullous systemic lupus erythematosus with autoantibodies recognizing multiple skin basement membrane components, bullous pemphigoid antigen 1, laminin-5, laminin-6, and type VII collagen. (10328198)
1999
40
Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes. (9427734)
1998
41
Concomitant manifestation of systemic lupus erythematosus and low-grade non-Hodgkin's lymphoma. (9264388)
1997
42
Subacute cutaneous lupus erythematosus associated with cilazapril. (7845155)
1995
43
Surface expression of heat shock protein 90 by blood mononuclear cells from patients with systemic lupus erythematosus. (1489490)
1992
44
Protein-losing enteropathy in systemic lupus erythematosus. (1843003)
1991
45
Subacute cutaneous lupus erythematosus lesions progressing to morphea. (2229533)
1990
46
Subacute cutaneous lupus erythematosus: a decade's perspective. (2671533)
1989
47
Cerebrospinal fluid IgM, IgA, and IgG indexes in systemic lupus erythematosus. Their use as estimates of central nervous system disease activity. (3899036)
1985
48
Annular atrophic plaques of the face. A variety of atrophic discoid lupus erythematosus? (782372)
1976
49
Coexistence of discoid lupus erythematosus and porphyria cutanea tarda. (1017227)
1976
50
Discoid lupus erythematosus. Electron microscopic studies of paramyxovirus-like structures. (5444077)
1970

Genetic Variations for Lupus Erythematosus

Expression for genes affiliated with Lupus Erythematosus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lupus Erythematosus

Search GEO for disease gene expression data for Lupus Erythematosus.

Pathways for genes affiliated with Lupus Erythematosus

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 56SinoBiological
See all sources

Pathways related to Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.8C4A, C4B, SSB, TRIM21, FCGR3A, C1QA
2
Hide members
11.8CTLA4, CR1, TLR5, C1QA, CALR, C4A
311.6C4A, C3, FCGR3A, C4B, FCGR2B, C1QA
4
Hide members
11.6C1QA, C4A, C4B, CR2, CR1, C3
5
Immune response Lectin induced complement pathway
Hide members
11.6C3, CR2, C4B, C4A, C1QA, CR1
6
Hide members
11.6C3, C1QA, TLR5, FASLG, STAT4, CALR
7
Hide members
11.4C1QA, C4A, C4B, C3, CR2
8
Hide members
11.4CR1, STAT4, FCGR3A, TLR5, C3
911.2CALR, C3, FCGR3A, FCGR2B
1011.2C3, C4A, C1QA, C4B
11
Hide members
11.2CR2, FCGR3A, FASLG, FCGR2B
12
Hide members
11.2FCGR2B, TLR5, CR2, STAT4
1311.2C3, CR1, FCGR2B, FCGR3A
14
Hide members
11.2CALR, TNFRSF13C, FASLG, CTLA4
15
Hide members
11.1C3, FCGR3A, FCGR2B
1611.1TLR5, CR1, C3
1711.1TLR5, C3, CR1
18
Hide members
11.1CR1, C4A, C1QA
1910.9C3, C4A

Compounds for genes affiliated with Lupus Erythematosus

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2416.2CALR, C1QA, TNFRSF13C, FASLG, CTLA4, C4B
2tyrosine4512.8TLR5, FCGR3A, CTLA4, PTPN22, FCGR2B, STAT4
3phosphatidylinositol4512.6C3, CR2, FCGR2B, CTLA4, TLR5, FASLG
4Intravenous Immunoglobulin1111.9C4B, FCGR2B, FCGR3A, C3, C4A
5rituximab45 50 1113.8FCGR3A, FCGR2B, CTLA4, FASLG, C1QA
6agarose4511.8C4B, DNASE1, C4A, C3, FASLG
7dexamethasone45 50 29 1114.8C3, FASLG, CTLA4, STAT4, CALR, DNASE1
8zinc45 2412.8C4B, CALR, CR2, TRIM21, DNASE1, FASLG
9polysaccharide4511.7CR1, FASLG, C3, CALR, DNASE1
10paraffin4511.7CR2, CR1, DNASE1, FASLG, DNASE1L3
11cyclosporin a45 29 6013.6CR1, FASLG, CTLA4, CR2, DNASE1
12heparin45 29 11 2414.6CALR, C3, CR1, FASLG
13mannose4511.5C3, FCGR3A, CALR, CR1
14serine4511.5C3, CTLA4, FCGR2B
15Palivizumab1111.5FCGR3A, C1QA, FCGR2B
16bevacizumab50 1112.4C1QA, FCGR2B, FCGR3A
17tositumomab50 1112.4FCGR3A, FCGR2B, C1QA
18Ibritumomab1111.4FCGR3A, FCGR2B, C1QA
19steroid4511.4C3, C4A, CTLA4, CALR, C4B
20alefacept45 1112.4FCGR3A, C1QA, FCGR2B
21Muromonab1111.4FCGR3A, FCGR2B, C1QA
22efalizumab45 1112.4FCGR3A, FCGR2B, C1QA
23daclizumab45 1112.4FCGR3A, FCGR2B, C1QA
24basiliximab45 1112.4FCGR3A, C1QA, FCGR2B
25gemtuzumab ozogamicin45 1112.4FCGR2B, FCGR3A, C1QA
26natalizumab45 1112.4C1QA, FCGR2B, FCGR3A
27alemtuzumab45 1112.4C1QA, FCGR2B, FCGR3A
28adalimumab45 50 1113.4FCGR3A, C1QA, FCGR2B
29abciximab45 1112.3FCGR2B, C1QA, FCGR3A
30cetuximab45 50 1113.3C1QA, FCGR2B, FCGR3A
31etanercept45 50 1113.3FCGR3A, FCGR2B, C1QA
32cr2+4511.2CR2, CR1
33ivig4511.2FASLG, FCGR3A, FCGR2B
34vitamin d4511.1CALR, DNASE1, CR1, CTLA4
35anaphylatoxin4511.1C4A, CR1
36trastuzumab45 50 1113.1C1QA, FCGR3A, FCGR2B
37estrogen4510.9FCGR2B, CR2
38aurintricarboxylic acid4510.6DNASE1L3, DNASE1

GO Terms for genes affiliated with Lupus Erythematosus

Sources:
16Gene Ontology
See all sources

Cellular components related to Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588612.4C3, TLR5, CTLA4, C4A, C4B, CR2
2extracellular regionGO:00557611.7C3, C1QA, FCGR3A, DNASE1, C4B, CALR
3external side of plasma membraneGO:00989711.5CALR, TNFRSF13C, FASLG, CTLA4, CR2, FCGR3A

Biological processes related to Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508712.3C4A, C4B, CR2, CR1, TRIM21, FCGR3A
2complement activation, classical pathwayGO:00695811.8C4A, C1QA, C4B, CR2, CR1, C3
3immune responseGO:00695511.5FASLG, CTLA4, CR2, C3, FCGR3A, FCGR2B
4regulation of complement activationGO:03044911.3C4A, C4B, CR1, C3
5complement activationGO:00695611.2C1QA, C3, C4A, C4B
6inflammatory responseGO:00695411.2TLR5, C4A, C4B, C3
7regulation of immune responseGO:05077610.8FCGR3A, C3, FCGR2B

Molecular functions related to Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.9FCGR3A, FCGR2B
2endopeptidase inhibitor activityGO:00486610.8C3, C4B, C4A

Products for genes affiliated with Lupus Erythematosus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lupus Erythematosus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet