SLE
MCID: LPS004
MIFTS: 73

Lupus Erythematosus (SLE) malady

Skin diseases category

Summaries for Lupus Erythematosus

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42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 If you have lupus, your immune system attacks healthy cells and tissues by mistake. this can damage your joints, skin, blood vessels and organs. there are many kinds of lupus. the most common type, systemic lupus erythematosus, affects many parts of the body. discoid lupus causes a rash that doesn't go away. subacute cutaneous lupus causes sores after being out in the sun. another type can be caused by medication. neonatal lupus, which is rare, affects newborns. anyone can get lupus, but women are most at risk. lupus is also more common in african american, hispanic, asian and native american women. the cause of lupus is not known. lupus has many symptoms. some common ones are joint pain or swelling muscle pain fever with no known cause fatigue red rashes, often on the face (also called the "butterfly rash") there is no one test to diagnose lupus, and it may take months or years to make the diagnosis. there is no cure for lupus, but medicines and lifestyle changes can help control it. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Lupus Erythematosus, also known as lupus, is related to systemic lupus erythematosus and arthritis. An important gene associated with Lupus Erythematosus is TRIM21 (tripartite motif containing 21), and among its related pathways are Alcoholism and Immune System. The drugs chloroquine and chloroquine phosphate and the compounds calcium and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and b cells, and related mouse phenotypes are immune system and homeostasis/metabolism.

NIH Rare Diseases:42 Lupus is an autoimmune disease. it can affect almost every organ in the body. symptoms of lupus can be very mild to life threatening. there are three types of lupus; systemic lupus erythematosus, discoid lupus, and drug-induced lupus. treatment of lupus depends on the severity of the condition and what parts of the body are affected. treatment may include acetaminophen, ibuprofen, antimalarial drugs, anti-inflammatory steroids, and/or immunosuppressive drugs. last updated: 3/11/2010

CDC:3 Systemic Lupus Erythematosus is an autoimmune disease in which the immune system produces antibodies to cells within the body leading to widespread inflammation and tissue damage. The causes of SLE are unknown but are believed to be linked to genetic, environmental, and hormonal factors. SLE may be characterized by periods of illness and remissions. SLE has a variety of clinical manifestations and can affect joints, skin, brain, lungs, kidneys, and blood vessels. People with SLE may experience fatigue, pain or swelling in joints, skin rashes, and fevers. A team approach in treating lupus is often warranted due to the number of organ systems involved.

Wikipedia:63 Lupus erythematosus is a name given to a collection of autoimmune diseases in which the human immune... more...

Aliases & Classifications for Lupus Erythematosus

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Sources:
42NIH Rare Diseases, 8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 33MedlinePlus, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

lupus erythematosus 8 42 10 44 60
lupus 8 42 33
subacute cutaneous lupus 42 60
disseminated lupus erythematosus 42
lupus erythematosus, discoid 60
lupus erythematosus nos 8
discoid lupus 42
sle 42


External Ids:

Disease Ontology8 DOID:8857
ICD9CM27 695.4
NCIt39 C27153
ICD1025 L93, L93.0

Related Diseases for Lupus Erythematosus

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Systemic Lupus Erythematosus family:

lupus erythematosus Dnase1-Related Susceptibility to Systemic Lupus Erythematosus
Cr2-Related Susceptibility to Systemic Lupus Erythematosus Systemic Lupus Erythematosus 14
Systemic Lupus Erythematosus 9 Systemic Lupus Erythematosus 1
Systemic Lupus Erythematosus 2 Systemic Lupus Erythematosus 16
Systemic Lupus Erythematosus 3 Systemic Lupus Erythematosus 13
Systemic Lupus Erythematosus 10 Systemic Lupus Erythematosus 12
Systemic Lupus Erythematosus 4 Systemic Lupus Erythematosus 5
Systemic Lupus Erythematosus 7 Systemic Lupus Erythematosus 8

Diseases related to Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 784)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus32.7FCGR2B, DNASE1
2arthritis31.7FCGR2B, CR1, CTLA4, FCGR3A, PTPN22, C3
3rheumatoid arthritis31.6CR1, CTLA4, FASLG, TNFRSF13C, CALR, STAT4
4vasculitis31.2CTLA4, TRIM21, C3
5connective tissue disease31.2C3, PTPN22, FCGR2B, DNASE1, TRIM21, CTLA4
6systemic scleroderma31.1CTLA4, SSB, PTPN22
7glomerulonephritis31.1C3, CR1
8complement deficiency31.1C3, CR1, C4A
9hepatitis31.1FASLG, CTLA4, CR1
10dermatitis31.0CTLA4
11congenital heart block31.0CALR, SSB, TRIM21
12thrombocytopenia30.9FCGR3A, FCGR2B
13thyroiditis30.9PTPN22, CTLA4, FASLG
14lymphopenia30.9PTPN22, FASLG
15tuberculosis30.9CALR, CR1, DNASE1, C3
16sarcoidosis30.8CR1
17myocardial infarction30.8DNASE1
18multiple sclerosis30.8TNFRSF13C, FASLG, CTLA4, C4B, CR1, STAT4
19vitiligo30.7CTLA4, C4B, PTPN22
20myasthenia gravis30.7CTLA4, CR1
21sjogren's syndrome30.7CALR, FASLG, CR1, SSB, TRIM21
22psoriasis30.7PTPN22, FCGR3A, CTLA4, TLR5
23subacute cutaneous lupus erythematosus30.7TRIM21, CALR
24leukemia30.6FASLG, CR2, CR1, DNASE1
25autoimmune thyroiditis30.6PTPN22, CTLA4, FASLG
26diabetes mellitus30.6CALR, CTLA4, PTPN22, C3
27hypothyroidism30.5CTLA4
28influenza30.5CALR, TLR5, CR1, DNASE1
29hepatitis b30.5DNASE1, CR1
30acute myocardial infarction30.5DNASE1
31celiac disease30.4CALR, CTLA4, PTPN22
32hepatitis c30.4CR1, CTLA4, CALR
33hereditary angioedema30.4C4B, CR1
34asthma30.3CTLA4, CR1, STAT4, DNASE1
35malaria30.3CR1
36encephalomyelitis30.2FASLG, CTLA4, CR1, STAT4
37graves' disease30.2PTPN22, FCRL3, CTLA4, FASLG
38myeloma30.2DNASE1, FASLG
39uveitis30.2CTLA4
40guillain-barre syndrome30.2CR1
41wegener's granulomatosis30.2CTLA4
42lupus nephritis29.9FCGR3A, DNASE1, CR1
43inflammatory bowel disease29.9TLR5, CTLA4, STAT4, PTPN22
44hyperthyroidism29.9PTPN22, CTLA4
45cystic fibrosis29.9DNASE1, CR1
46chagas disease29.9CALR
47burkitt's lymphoma29.9FCGR2B, CR2, FASLG
48chronic lymphocytic leukemia29.5TNFRSF13C, CTLA4, CR2, CR1
49common variable immune deficiency29.5TNFRSF13C
50cutaneous lupus erythematosus11.4

Graphical network of the top 20 diseases related to Lupus Erythematosus:



Diseases related to lupus erythematosus

Clinical Features for Lupus Erythematosus

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Drugs & Therapeutics for Lupus Erythematosus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lupus Erythematosus

Drug clinical trials:

Search ClinicalTrials for Lupus Erythematosus

Search NIH Clinical Center for Lupus Erythematosus

Search CenterWatch for Lupus Erythematosus

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Lupus Erythematosus

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Anatomical Context for Lupus Erythematosus

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Sources:
32MalaCards
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MalaCards organs/tissues related to Lupus Erythematosus:

32
T cells, Skin, B cells, Heart, Lung, Kidney, Endothelial, Testes, Brain, Monocytes, Bone, Liver, Thyroid, Breast, Bone marrow, Pituitary, Myeloid, Salivary gland, Spleen, Whole blood, Nk cells, Colon, Prostate, Spinal cord, Placenta, Smooth muscle, Skeletal muscle, Pineal, Thymus, Eye, Uterus, Temporal lobe

Animal Models for Lupus Erythematosus or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Lupus Erythematosus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538713.3C3, C1QA, TLR5, TNFRSF13C, FASLG, CTLA4
2MP:000537613.3C4B, CTLA4, FASLG, TNFRSF13C, TLR5, CALR
3MP:000538413.0FASLG, TNFRSF13C, TLR5, CALR, C1QA, CTLA4
4MP:001076812.9C4B, CTLA4, FASLG, CALR, C1QA, CR2
5MP:000539712.8TLR5, TNFRSF13C, FASLG, CTLA4, C4B, CR2
6MP:000536712.5C1QA, FASLG, C4B, CR2, STAT4, TRIM21
7MP:000538111.6C3, FCGR2B, C4B, CTLA4, FASLG, TLR5
8MP:000537011.5TLR5, FASLG, CTLA4, C4B, FCGR2B, PTPN22

Publications for Lupus Erythematosus

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Sources:
50PubMed
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Articles related to Lupus Erythematosus:

(show top 50)    (show all 5738)
idTitleAuthorsYear
1
Progressive disseminated histoplasmosis in systemic lupus erythematosus-an unusual presentation of acute tenosynovitis and a literature review. (23065146)
2013
2
Lymphopenia Helps Early Diagnosis of Systemic Lupus Erythematosus for Patients With Psychosis as an Initial Symptom. (24070661)
2013
3
Relation of Platelet C4d with All-Cause Mortality and Ischemic Stroke in Patients with Systemic Lupus Erythematosus. (24323718)
2013
4
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
5
XRCC1 Arg399Gln gene polymorphism and the risk of systemic lupus erythematosus in the Polish population. (21682595)
2012
6
Suppression of UV-induced damage by a liposomal sunscreen: a prospective, open-label study in patients with cutaneous lupus erythematosus and healthy controls. (23171460)
2012
7
Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus. (21383913)
2011
8
Impact of C1q deficiency on the severity and outcome of childhood systemic lupus erythematosus. (21303486)
2011
9
Elevated circulating CD4+ ICOS+ Foxp3+ T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic lupus erythematosus. (21558138)
2011
10
Periodontal disease as a risk factor for cardiovascular disease: suggestion of a further link in systemic lupus erythematosus. (21601991)
2011
11
Increased risk for heart valve disease associated with antiphospholipid antibodies in patients with systemic lupus erythematosus: meta-analysis of echocardiographic studies. (21690492)
2011
12
Valvular heart disease in systemic lupus erythematosus and Jaccoud's arthropathy. (19851768)
2011
13
Comparative analysis of subacute cutaneous lupus erythematosus and chronic cutaneous lupus erythematosus: clinical and immunological study of 270 patients. (19785596)
2010
14
Endothelial nitric oxide synthase and nicotinamide adenosine dinucleotide phosphate oxidase p22phox gene (C242T) polymorphisms and systemic lupus erythematosus in a Chinese Population. (19965945)
2010
15
Dramatic response of scarring scalp discoid lupus erythematosus (DLE) to intravenous methylprednisolone, oral corticosteroids, and hydroxychloroquine in a 5-year-old child. (19706100)
2009
16
The CD3Z 844 T>A polymorphism within the 3'-UTR of CD3Z confers increased risk of incidence of systemic lupus erythematosus. (19422667)
2009
17
Activation of the interferon-gamma signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells. (19404947)
2009
18
Hemarthrosis as acute presentation of acquired hemophilia in a patient with systemic lupus erythematosus: successful treatment and long-lasting remission. (18827958)
2008
19
Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus? (18155417)
2008
20
A case of discoid lupus erythematosus masquerading as acne. (18311454)
2008
21
Circulating proangiogenic molecules PIGF, SDF-1 and sVCAM-1 in patients with systemic lupus erythematosus. (17964973)
2007
22
Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus. (17640359)
2007
23
A serology-based approach combined with clinical examination of 125 Ro/SSA-positive patients to define incidence and prevalence of subacute cutaneous lupus erythematosus. (17195229)
2007
24
Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus. (17579055)
2007
25
Activation of type I interferon in systemic lupus erythematosus. (20477162)
2007
26
Identification of distinct gene expression profiles in the synovium of patients with systemic lupus erythematosus. (17469140)
2007
27
An altered immune response to Epstein-Barr nuclear antigen 1 in pediatric systemic lupus erythematosus. (16385527)
2006
28
Genetic contribution of the tumour necrosis factor (TNF) B + 252*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients. (15932622)
2005
29
Interferon-alpha in systemic lupus erythematosus. (15314491)
2004
30
Autoantibody profile in systemic lupus erythematosus with psychiatric manifestations: a role for anti-endothelial-cell antibodies. (15225372)
2004
31
Systemic lupus erythematosus in Tunisia: demographic and clinical analysis of 100 patients. (15119551)
2004
32
The concomitant presence of lupus anticoagulant, anticardiolipin and anti-beta2-glycoprotein i antibodies could be associated with acquired activated protein c resistance in non-systemic lupus erythematosus patients. (12716380)
2003
33
Antimalarials in cutaneous lupus erythematosus: mechanisms of therapeutic benefit. (11958581)
2002
34
Expression of cyclin B1 and cyclin dependent kinase inhibitor p21 in lymphocytes in patients with systemic lupus erythematosus. (12465148)
2002
35
Fc gamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. (12115230)
2002
36
Diagnostic value of combined evaluation of neopterin and anti-DNA antibody levels for assessment of disease activity in systemic lupus erythematosus. (11138331)
2000
37
Defective B7 expression on antigen-presenting cells underlying T cell activation abnormalities in systemic lupus erythematosus (SLE) patients. (8603537)
1996
38
Diltiazem and subacute cutaneous lupus erythematosus-like lesions. (7477141)
1995
39
Protein S deficiency in lupus erythematosus secondary to hereditary angio-oedema. (8148282)
1994
40
Rhabdomyolysis in a patient with discoid lupus erythematosus. (7837170)
1994
41
Systemic lupus erythematosus presenting with diffuse low density lesions in the cerebral white matter on computed axial tomography scans: its implication in the pathogenesis of diffuse central nervous system lupus. (7799363)
1994
42
The diagnosis and treatment of discoid lupus erythematosus with oral manifestations only: a case report. (7994728)
1994
43
Hereditary deficiency of C5 in association with discoid lupus erythematosus. (1999552)
1991
44
Fetal-pericardial effusion in association with congenital heart block and maternal systemic lupus erythematosus. Case report. (2390508)
1990
45
Dapsone is an effective therapy for the skin lesions of subacute cutaneous lupus erythematosus and urticarial vasculitis in a patient with C2 deficiency. (2290166)
1990
46
Anterior spinal artery syndrome in systemic lupus erythematosus. (2743095)
1989
47
Discoid lupus erythematosus occurring in a smallpox vaccination scar. (3668013)
1987
48
Pernicious anemia in a patient with systemic lupus erythematosus. (3692754)
1987
49
Chronic interstitial cystitis as an initial major manifestation of systemic lupus erythematosus. (6975827)
1981
50
Long-term use of prednisone (meticorten) in generalized cases of lupus erythematosus, scleroderma and neurodermatitis disseminata. (13573304)
1958

Genetic Variations for Lupus Erythematosus

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Expression for genes affiliated with Lupus Erythematosus

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lupus Erythematosus

Search GEO for disease gene expression data for Lupus Erythematosus.

Pathways for genes affiliated with Lupus Erythematosus

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Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 55SinoBiological
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Pathways related to Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.8C1QA, C4A, C4B, SSB, TRIM21, FCGR3A
2
Hide members
11.8C1QA, CALR, TLR5, CTLA4, C4A, CR1
311.6C3, FCGR3A, FCGR2B, C4B, C4A, C1QA
4
Hide members
11.6C1QA, C4A, C4B, CR2, CR1, C3
5
Immune response Lectin induced complement pathway
Hide members
11.6C1QA, C4A, C4B, CR2, CR1, C3
6
Hide members
11.6C1QA, CALR, TLR5, FASLG, STAT4, C3
7
Hide members
11.4C1QA, C4A, C4B, CR2, C3
8
Hide members
11.4TLR5, CR1, STAT4, FCGR3A, C3
911.2CALR, FCGR2B, FCGR3A, C3
1011.2C1QA, C4A, C4B, C3
11
Hide members
11.2FCGR3A, FCGR2B, CR2, FASLG
12
Hide members
11.2TLR5, CR2, STAT4, FCGR2B
1311.2C3, FCGR3A, FCGR2B, CR1
14
Hide members
11.2CALR, TNFRSF13C, FASLG, CTLA4
15
Hide members
11.1C3, FCGR3A, FCGR2B
1611.1C3, CR1, TLR5
1711.1TLR5, CR1, C3
18
Hide members
11.1CR1, C4A, C1QA
1910.9C4A, C3

Compounds for genes affiliated with Lupus Erythematosus

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2416.2C1QA, CALR, TNFRSF13C, FASLG, CTLA4, C4B
2tyrosine4412.8CTLA4, FASLG, TLR5, CALR, CR2, CR1
3phosphatidylinositol4412.6TLR5, FASLG, CTLA4, CR2, CR1, STAT4
4Intravenous Immunoglobulin1111.9C3, FCGR3A, FCGR2B, C4B, C4A
5rituximab44 49 1113.8C1QA, FASLG, CTLA4, FCGR2B, FCGR3A
6agarose4411.8FASLG, C4A, C4B, DNASE1, C3
7dexamethasone44 49 28 1114.8C3, DNASE1, STAT4, CTLA4, FASLG, CALR
8zinc44 2412.8DNASE1, TRIM21, CR2, C4B, FASLG, CALR
9polysaccharide4411.7CALR, FASLG, CR1, DNASE1, C3
10paraffin4411.7DNASE1L3, DNASE1, CR1, CR2, FASLG
11cyclosporin a44 28 5913.6FASLG, CTLA4, CR2, CR1, DNASE1
12heparin44 28 11 2414.6C3, CR1, FASLG, CALR
13mannose4411.5CALR, CR1, FCGR3A, C3
14serine4411.5C3, FCGR2B, CTLA4
15Palivizumab1111.5FCGR3A, FCGR2B, C1QA
16Ibritumomab1111.4C1QA, FCGR2B, FCGR3A
17bevacizumab49 1112.4C1QA, FCGR2B, FCGR3A
18tositumomab49 1112.4C1QA, FCGR2B, FCGR3A
19steroid4411.4C3, C4B, C4A, CTLA4, CALR
20alefacept44 1112.4C1QA, FCGR2B, FCGR3A
21Muromonab1111.4C1QA, FCGR2B, FCGR3A
22efalizumab44 1112.4C1QA, FCGR2B, FCGR3A
23daclizumab44 1112.4C1QA, FCGR2B, FCGR3A
24basiliximab44 1112.4FCGR3A, FCGR2B, C1QA
25gemtuzumab ozogamicin44 1112.4C1QA, FCGR2B, FCGR3A
26alemtuzumab44 1112.4FCGR3A, FCGR2B, C1QA
27natalizumab44 1112.4FCGR3A, FCGR2B, C1QA
28adalimumab44 49 1113.4C1QA, FCGR2B, FCGR3A
29abciximab44 1112.3FCGR3A, FCGR2B, C1QA
30cetuximab44 49 1113.3C1QA, FCGR2B, FCGR3A
31etanercept44 49 1113.3C1QA, FCGR2B, FCGR3A
32cr2+4411.2CR1, CR2
33ivig4411.2FASLG, FCGR2B, FCGR3A
34vitamin d4411.1CALR, CTLA4, CR1, DNASE1
35anaphylatoxin4411.1CR1, C4A
36trastuzumab44 49 1113.1FCGR3A, FCGR2B, C1QA
37estrogen4410.9FCGR2B, CR2
38aurintricarboxylic acid4410.6DNASE1L3, DNASE1

GO Terms for genes affiliated with Lupus Erythematosus

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16Gene Ontology
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Cellular components related to Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588612.4CTLA4, C4A, C4B, CR2, CR1, FCRL3
2extracellular regionGO:00557611.7C1QA, CALR, FASLG, C4A, C4B, DNASE1
3external side of plasma membraneGO:00989711.5FCGR3A, CALR, TNFRSF13C, FASLG, CTLA4, CR2

Biological processes related to Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508712.3C1QA, TLR5, C4A, C4B, CR2, CR1
2complement activation, classical pathwayGO:00695811.8C3, C1QA, C4A, C4B, CR2, CR1
3immune responseGO:00695511.5FASLG, CTLA4, CR2, FCGR2B, FCGR3A, C3
4regulation of complement activationGO:03044911.3C4A, C4B, CR1, C3
5complement activationGO:00695611.2C3, C4B, C4A, C1QA
6inflammatory responseGO:00695411.2C3, C4B, C4A, TLR5
7regulation of immune responseGO:05077610.8FCGR2B, FCGR3A, C3

Molecular functions related to Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.9FCGR3A, FCGR2B
2endopeptidase inhibitor activityGO:00486610.8C3, C4B, C4A

Products for genes affiliated with Lupus Erythematosus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lupus Erythematosus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet