SLE
MCID: LPS004
MIFTS: 72

Lupus Erythematosus (SLE) malady

Genetic diseases, Rare diseases, Skin diseases, Immune diseases, Bone diseases categories
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Summaries for Lupus Erythematosus

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Sources:
43NIH Rare Diseases, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 If you have lupus, your immune system attacks healthy cells and tissues by mistake. this can damage your joints, skin, blood vessels and organs. there are many kinds of lupus. the most common type, systemic lupus erythematosus, affects many parts of the body. discoid lupus causes a rash that doesn't go away. subacute cutaneous lupus causes sores after being out in the sun. another type can be caused by medication. neonatal lupus, which is rare, affects newborns. anyone can get lupus, but women are most at risk. lupus is also more common in african american, hispanic, asian and native american women. the cause of lupus is not known. lupus has many symptoms. some common ones are joint pain or swelling muscle pain fever with no known cause fatigue red rashes, often on the face (also called the "butterfly rash") there is no one test to diagnose lupus, and it may take months or years to make the diagnosis. there is no cure for lupus, but medicines and lifestyle changes can help control it. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Lupus Erythematosus, also known as lupus, is related to systemic lupus erythematosus and subacute cutaneous lupus erythematosus. An important gene associated with Lupus Erythematosus is TLR5 (toll-like receptor 5), and among its related pathways are CD28 co-stimulation and B Cell Receptor Signaling Pathway. The drugs chloroquine and chloroquine phosphate and the compounds tositumomab and ibritumomab have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and b cells, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

NIH Rare Diseases:43 Lupus is an autoimmune disease. it can affect almost every organ in the body. symptoms of lupus can be very mild to life threatening. there are three types of lupus; systemic lupus erythematosus, discoid lupus, and drug-induced lupus. treatment of lupus depends on the severity of the condition and what parts of the body are affected. treatment may include acetaminophen, ibuprofen, antimalarial drugs, anti-inflammatory steroids, and/or immunosuppressive drugs. last updated: 3/11/2010

CDC:4 Systemic Lupus Erythematosus is an autoimmune disease in which the immune system produces antibodies to cells within the body leading to widespread inflammation and tissue damage. The causes of SLE are unknown but are believed to be linked to genetic, environmental, and hormonal factors. SLE may be characterized by periods of illness and remissions. SLE has a variety of clinical manifestations and can affect joints, skin, brain, lungs, kidneys, and blood vessels. People with SLE may experience fatigue, pain or swelling in joints, skin rashes, and fevers. A team approach in treating lupus is often warranted due to the number of organ systems involved.

Wikipedia:65 Lupus erythematosus is a name given to a collection of autoimmune diseases in which the human immune... more...

Aliases & Classifications for Lupus Erythematosus

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43NIH Rare Diseases, 8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 34MedlinePlus, 40NCIt, 27ICD9CM, 58SNOMED-CT, 25ICD10
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Classifications:



Aliases & Descriptions:

lupus erythematosus 8 43 10 45 62
lupus 8 43 34
subacute cutaneous lupus 43 62
disseminated lupus erythematosus 43
systemic lupus erythematosus 43
lupus erythematosus, discoid 62
lupus erythematosus nos 8
discoid lupus 43
sle 43


External Ids:

Disease Ontology8 DOID:8857
NCIt40 C27153
ICD9CM27 695.4
ICD1025 L93, L93.0

Related Diseases for Lupus Erythematosus

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17GeneCards, 18GeneDecks
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Diseases in the Systemic Lupus Erythematosus family:

lupus erythematosus Dnase1-Related Susceptibility to Systemic Lupus Erythematosus
Cr2-Related Susceptibility to Systemic Lupus Erythematosus Systemic Lupus Erythematosus 14
Systemic Lupus Erythematosus 9 Systemic Lupus Erythematosus 1
Systemic Lupus Erythematosus 2 Systemic Lupus Erythematosus 16
Systemic Lupus Erythematosus 3 Systemic Lupus Erythematosus 13
Systemic Lupus Erythematosus 10 Systemic Lupus Erythematosus 12
Systemic Lupus Erythematosus 4 Systemic Lupus Erythematosus 5
Systemic Lupus Erythematosus 7 Systemic Lupus Erythematosus 8

Diseases related to Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 934)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus32.9FCGR2B, DNASE1
2subacute cutaneous lupus erythematosus32.0CALR, TRIM21
3arthritis31.8PTPN22, FCGR2B, FCGR3A, C3, CTLA4
4rheumatoid arthritis31.6TNFRSF13C, PTPN22, FCGR2B, FCRL3, FCGR3A, STAT4
5nephritis31.5C4A, C3, FCGR3A
6vasculitis31.5C3, CTLA4, TRIM21
7lupus nephritis31.4FCGR3A, DNASE1, PDCD1
8connective tissue disease31.4PTPN22, FCGR2B, DNASE1, C3, CTLA4, TRIM21
9congenital heart block31.2SSB, CALR, TRIM21
10thyroiditis31.1CTLA4, PTPN22
11rheumatic disease31.0TRIM21
12complement deficiency31.0C4A, C3
13vitiligo30.9C4B, CTLA4, PTPN22
14multiple sclerosis30.9TNFRSF13C, PTPN22, STAT4, PDCD1, CTLA4, C4B
15sjogren's syndrome30.9TRIM21, CALR, SSB
16psoriasis30.8CTLA4, FCGR3A, PTPN22, TLR5
17systemic scleroderma30.8CTLA4, SSB, PTPN22
18diabetes mellitus30.8CTLA4, CALR, C3, PTPN22
19primary biliary cirrhosis30.7CTLA4, PDCD1, CALR
20influenza30.6TLR5, DNASE1, CALR
21b-cell lymphomas30.6CR2, FCGR2B, TNFRSF13C
22celiac disease30.6CTLA4, CALR, PTPN22
23sepsis30.5TLR5, FCGR3A, C3, C4A
24type 1 diabetes mellitus30.5PTPN22, C3, PDCD1, CTLA4, C4A
25graves' disease30.4PTPN22, FCRL3, CTLA4
26inflammatory bowel disease30.1CTLA4, STAT4, PTPN22, TLR5
27burkitt's lymphoma30.1TNFRSF13C, FCGR2B, STAT4, DNASE1, PDCD1, CR2
28ulcerative colitis30.1CTLA4, STAT4, TLR5
29common variable immune deficiency29.7TNFRSF13C
30chronic lymphocytic leukemia29.7TNFRSF13C, CR2, CTLA4
31non-hodgkin lymphoma29.6CR2, FCGR3A, TNFRSF13C
32cutaneous lupus erythematosus11.4
33discoid lupus erythematosus11.4
34pediatric systemic lupus erythematosus11.0
35antiphospholipid syndrome11.0
36panniculitis10.9
37systemic lupus erythematosus, association with10.9
38bullous systemic lupus erythematosus10.9
39endotheliitis10.9
40myelitis10.8
41lupus erythematosus panniculitis10.8
42drug-induced lupus erythematosus10.8
43lupus erythematosus tumidus10.8
44scleroderma10.8
45protein-losing enteropathy10.8
46mixed connective tissue disease10.8
47atherosclerosis10.8
48purpura10.8
49cerebritis10.8
50glomerulonephritis10.8

Graphical network of the top 20 diseases related to Lupus Erythematosus:



Diseases related to lupus erythematosus

Symptoms for Lupus Erythematosus

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Drugs & Therapeutics for Lupus Erythematosus

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Lupus Erythematosus

Search NIH Clinical Center for Lupus Erythematosus

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Lupus Erythematosus

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Anatomical Context for Lupus Erythematosus

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33MalaCards
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MalaCards organs/tissues related to Lupus Erythematosus:

33
T cells, Skin, B cells, Heart, Lung, Kidney, Endothelial, Testes, Brain, Monocytes, Bone, Liver, Thyroid, Breast, Bone marrow, Pituitary, Salivary gland, Spleen, Myeloid, Nk cells, Whole blood, Colon, Prostate, Placenta, Spinal cord, Skeletal muscle, Smooth muscle, Thymus, Eye, Uterus, Temporal lobe

Animal Models for Lupus Erythematosus or affiliated genes

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37MGI
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Publications for Lupus Erythematosus

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52PubMed
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Articles related to Lupus Erythematosus:

(show top 50)    (show all 5670)
idTitleAuthorsYear
1
T lymphocyte apoptosis in systemic lupus erythematosus patients. (24106599)
2013
2
Vitamin d deficiency and systemic lupus erythematosus: cause or consequence? (23904929)
2013
3
Association of RANTES and MBL gene polymorphisms with systemic lupus erythematosus: a meta-analysis. (23065234)
2013
4
Factors that determine body composition of female systemic lupus erythematosus (SLE) patients in Sri Lanka: a comparative study using dual-energy x-ray absorptiometry. (23861026)
2013
5
Diffuse dystrophic calcinosis cutis of the scalp in a patient with scalp discoid lupus erythematosus and systemic lupus erythematosus. (23426499)
2013
6
Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus. (24379124)
2013
7
Irritable bowel syndrome-type symptoms in female patients with mild systemic lupus erythematosus: frequency, related factors and quality of life. (24112121)
2013
8
Infliximab-induced discoid lupus erythematosus. (23554040)
2013
9
Polimorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus. (22235789)
2012
10
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
11
Severe symmetrical facial lipoatrophy in a patient with discoid lupus erythematosus. (22976708)
2012
12
Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus. (21163672)
2011
13
Squamous cell carcinoma arising in discoid lupus erythematosus lesions of the ears infected with human papillomavirus. (21140928)
2010
14
Extragonadal germ cell tumor presenting in a woman with systemic lupus erythematosus: a case report. (20338049)
2010
15
Overview of common, rare and atypical manifestations of cutaneous lupus erythematosus and histopathological correlates. (20693199)
2010
16
Histopathologic characteristics of neonatal cutaneous lupus erythematosus: description of five cases and literature review. (19515045)
2009
17
Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression. (18625638)
2008
18
HLA-DRB1 alleles in juvenile-onset systemic lupus erythematosus: renal histologic class correlations. (17401504)
2007
19
Preliminary clinical measurement of the expression of B-cell activating factor in Chinese systemic lupus erythematosus patients. (17506477)
2007
20
Circulating proangiogenic molecules PIGF, SDF-1 and sVCAM-1 in patients with systemic lupus erythematosus. (17964973)
2007
21
Squamous cell carcinoma in black patients with discoid lupus erythematosus. (17330632)
2006
22
Subacute cutaneous lupus erythematosus: 25-year evolution of a prototypic subset (subphenotype) of lupus erythematosus defined by characteristic cutaneous, pathological, immunological, and genetic findings. (15990071)
2005
23
Expression of p53 and apoptosis in discoid lupus erythematosus. (16100773)
2005
24
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
25
The A/T mutation in exon 2 of the DNASE1 gene is not present in Tunisian patients with systemic lupus erythematosus or in healthy subjects. (14613299)
2003
26
Lupus erythematosus tumidus in childhood. Report of 3 patients. (12920372)
2003
27
Drug-induced lupus erythematosus by amiodarone. (11926860)
2002
28
Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. (12145745)
2002
29
Subacute cutaneous lupus erythematosus associated with hepatocellular carcinoma. (11309033)
2001
30
Coronary artery disease in systemic lupus erythematosus: A review of the literature. (11404827)
2001
31
Serum levels of angiogenic cytokines in systemic lupus erythematosus and their correlation with disease activity. (11566625)
2001
32
Hypercalcaemia in systemic lupus erythematosus. (11346230)
2001
33
Bone tissue metabolism in systematic lupus erythematosus patients treated with glucocorticosteroids]. (11993409)
2001
34
Nocardiosis in patients with systemic lupus erythematosus. The Singapore Lupus Study Group. (10813308)
2000
35
Chronic intestinal pseudo-obstruction in systemic lupus erythematosus due to intestinal smooth muscle myopathy. (10981652)
2000
36
Questions answered and a $1 million question raised concerning lupus erythematosus tumidus: is routine laboratory surveillance testing during treatment with hydroxychloroquine for skin disease really necessary. (10926741)
2000
37
The cutaneous pathology associated with seropositivity for antibodies to SSA (Ro): a clinicopathologic study of 23 adult patients without subacute cutaneous lupus erythematosus. (10218672)
1999
38
Echocardiography in systemic lupus erythematosus. (9863896)
1998
39
Animal models of cutaneous lupus erythematosus and lupus erythematosus photosensitivity. (9061668)
1997
40
Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease. (9202064)
1997
41
Human parvovirus infection: rheumatic manifestations, angioedema, C1 esterase inhibitor deficiency, ANA positivity, and possible onset of systemic lupus erythematosus. (8823689)
1996
42
Elevated soluble CD27 levels in serum of patients with systemic lupus erythematosus. (8938100)
1996
43
Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus. (7706484)
1995
44
A canine case of discoid lupus erythematosus with circulating autoantibody. (8720056)
1995
45
Childhood discoid lupus erythematosus. (8170860)
1994
46
Activation markers on peripheral blood T cells from patients with active or inactive systemic lupus erythematosus. Correlation with proliferative responses and production of IL-2. (1812897)
1991
47
Systemic lupus erythematosus and miliary tuberculosis in a prepubertal girl--a case report. (2152059)
1990
48
Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. (3861745)
1985
49
Oral discoid lupus erythematosus. I. The validity of previous histopathologic diagnostic criteria. (6582433)
1984
50
Concurrent localized scleroderma and discoid lupus erythematosus. Cutaneous 'mixed' or 'overlap' syndrome. (718182)
1978

Variations for Lupus Erythematosus

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Lupus Erythematosus:

1
id Gene Name Type Significance SNP ID Assembly Location
1TREX1NM_016381.5(TREX1): c.506G> A (p.Arg169His)single nucleotide variantPathogenic, risk factorrs72556554GRCh37Chr 3, 48508395: 48508395

Expression for genes affiliated with Lupus Erythematosus

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lupus Erythematosus

Search GEO for disease gene expression data for Lupus Erythematosus.

Pathways for genes affiliated with Lupus Erythematosus

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50PathCards, 55Reactome, 53QIAGEN, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters, 57SinoBiological
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Pathways related to Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1PTPN22, PDCD1, CTLA4
210.0BANK1, CR2, FCGR2B
310.0C3, FCGR3A, FCGR2B
410.0C3, FCGR3A, FCGR2B
5
Show member pathways
10.0TLR5, FCGR2B, STAT4, CR2
6
Show member pathways
9.9TNFRSF13C, CALR, CTLA4, C4A
7
Show member pathways
9.9TLR5, FCGR3A, STAT4, C3
89.9C4B, C4A, C3, C1QA
9
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.9CTLA4, CR2, PDCD1, FCGR2B
10
Show member pathways
9.9C4A, C3, FCGR3A, C1QA
119.9FCGR2B, FCGR3A, C3, CALR
12
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.8C1QA, TLR5, STAT4, C3, CALR
13
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.8C1QA, C3, CR2, C4A, C4B
14
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.8C1QA, C3, CR2, C4A, C4B
159.6C4B, C4A, C3, FCGR3A, FCGR2B, C1QA
16
Show member pathways
9.5FCGR2B, FCGR3A, C3, CALR, PDCD1, CTLA4
17
Show member pathways
9.4C1QA, FCGR3A, SSB, C3, C4A, C4B

Compounds for genes affiliated with Lupus Erythematosus

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51PharmGKB, 11DrugBank, 45Novoseek, 29IUPHAR, 24HMDB
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Compounds related to Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1tositumomab51 1111.4C1QA, FCGR2B, FCGR3A
2ibritumomab51 1111.4FCGR3A, FCGR2B, C1QA
3alefacept45 1111.4C1QA, FCGR2B, FCGR3A
4bevacizumab51 1111.3FCGR3A, FCGR2B, C1QA
5efalizumab45 1111.3FCGR3A, FCGR2B, C1QA
6daclizumab45 1111.3C1QA, FCGR2B, FCGR3A
7basiliximab45 1111.3FCGR3A, FCGR2B, C1QA
8natalizumab45 1111.3C1QA, FCGR2B, FCGR3A
9alemtuzumab45 1111.3C1QA, FCGR2B, FCGR3A
10gemtuzumab ozogamicin51 45 1112.3FCGR3A, FCGR2B, C1QA
11adalimumab45 51 1112.3C1QA, FCGR2B, FCGR3A
12abciximab45 1111.3FCGR3A, FCGR2B, C1QA
13allergens4510.3CTLA4, PDCD1, STAT4
14aurintricarboxylic acid4510.3DNASE1L3, DNASE1
15cetuximab45 51 1112.2FCGR3A, FCGR2B, C1QA
16etanercept45 51 1112.2FCGR3A, FCGR2B, C1QA
17rituximab45 51 1112.2C1QA, FCGR2B, FCGR3A, CTLA4
18trastuzumab45 51 1112.2C1QA, FCGR2B, FCGR3A
19agarose4510.2DNASE1, C3, C4A, C4B
20steroid4510.0C3, CALR, CTLA4, C4A, C4B
21dexamethasone45 51 29 1113.0CTLA4, CALR, C3, DNASE1, STAT4
22zinc45 2410.9DNASE1, CALR, CR2, C4B, TRIM21
23heparin45 29 24 1112.9C4B, CALR, C3, DNASE1
24mannose459.9CALR, C3, FCGR3A
25phosphatidylinositol459.9TLR5, FCGR2B, FCGR3A, STAT4, C3, CR2
26threonine459.8CALR, CR2, CTLA4, C4A, C4B
27serine459.7C4B, FCGR2B, STAT4, DNASE1, C3, CALR
28tyrosine459.6TLR5, PTPN22, FCGR2B, FCGR3A, STAT4, CALR
29estrogen459.5FCGR2B, DNASE1, C3, CR2, CTLA4
30calcium45 51 24 1112.4C1QA, TNFRSF13C, FCGR2B, FCGR3A, DNASE1, DNASE1L3

GO Terms for genes affiliated with Lupus Erythematosus

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16Gene Ontology
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Cellular components related to Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:07256210.1C4B, C4A, C3
2external side of plasma membraneGO:0098979.6CTLA4, TNFRSF13C, FCGR3A, CALR, PDCD1, CR2
3extracellular regionGO:0055769.2C1QA, FCGR3A, DNASE1, C3, CALR, C4A
4plasma membraneGO:0058868.9TLR5, FCGR2B, FCRL3, FCGR3A, C3, PDCD1

Biological processes related to Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell cycleGO:04578710.2TRIM21, CALR
2regulation of complement activationGO:03044910.2C3, C4A, C4B
3complement activationGO:00695610.1C4B, C4A, C3, C1QA
4T cell costimulationGO:03129510.1CTLA4, PDCD1, TNFRSF13C
5complement activation, classical pathwayGO:00695810.0C4B, C4A, CR2, C3, C1QA
6inflammatory responseGO:00695410.0TLR5, C3, C4A, C4B
7positive regulation of phagocytosisGO:0507669.9CALR, C3
8regulation of immune responseGO:0507769.9C3, FCGR3A, FCGR2B
9immune responseGO:0069559.9FCGR2B, FCGR3A, C3, CR2, CTLA4
10innate immune responseGO:0450879.6C1QA, TLR5, FCGR3A, C3, CR2, C4A

Molecular functions related to Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00486610.0C4B, C4A, C3
2IgG bindingGO:0198649.8FCGR3A, FCGR2B
3protein bindingGO:0055159.0PTPN22, FCGR2B, SSB, DNASE1, C3, CALR

Products for genes affiliated with Lupus Erythematosus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lupus Erythematosus

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet