MCID: LPS004
MIFTS: 67

Lupus Erythematosus malady

Genetic diseases, Rare diseases, Skin diseases, Bone diseases categories

Summaries for Lupus Erythematosus

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MedlinePlus:32 If you have lupus, your immune system attacks healthy cells and tissues by mistake. this can damage your joints, skin, blood vessels and organs. there are many kinds of lupus. the most common type, systemic lupus erythematosus, affects many parts of the body. discoid lupus causes a rash that doesn't go away. subacute cutaneous lupus causes sores after being out in the sun. another type can be caused by medication. neonatal lupus, which is rare, affects newborns. anyone can get lupus, but women are most at risk. lupus is also more common in african american, hispanic, asian and native american women. the cause of lupus is not known. lupus has many symptoms. some common ones are joint pain or swelling muscle pain fever with no known cause fatigue red rashes, often on the face (also called the "butterfly rash") there is no one test to diagnose lupus, and it may take months or years to make the diagnosis. there is no cure for lupus, but medicines and lifestyle changes can help control it. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Lupus Erythematosus, also known as lupus, is related to systemic lupus erythematosus and subacute cutaneous lupus erythematosus. An important gene associated with Lupus Erythematosus is TLR5 (toll-like receptor 5), and among its related pathways are CD28 co-stimulation and B Cell Receptor Signaling Pathway. The drugs azathioprine and cyclosporine and the compounds tositumomab and ibritumomab have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and b cells, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

NIH Rare Diseases:41 Lupus is an autoimmune disease. it can affect almost every organ in the body. symptoms of lupus can be very mild to life threatening. there are three types of lupus; systemic lupus erythematosus, discoid lupus, and drug-induced lupus. treatment of lupus depends on the severity of the condition and what parts of the body are affected. treatment may include acetaminophen, ibuprofen, antimalarial drugs, anti-inflammatory steroids, and/or immunosuppressive drugs. last updated: 3/11/2010

CDC:3 Systemic Lupus Erythematosus is an autoimmune disease in which the immune system produces antibodies to cells within the body leading to widespread inflammation and tissue damage. The causes of SLE are unknown but are believed to be linked to genetic, environmental, and hormonal factors. SLE may be characterized by periods of illness and remissions. SLE has a variety of clinical manifestations and can affect joints, skin, brain, lungs, kidneys, and blood vessels. People with SLE may experience fatigue, pain or swelling in joints, skin rashes, and fevers. A team approach in treating lupus is often warranted due to the number of organ systems involved.

Wikipedia:63 Lupus erythematosus is a name given to a collection of autoimmune diseases in which the human immune... more...

Aliases & Classifications for Lupus Erythematosus

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Lupus Erythematosus, Aliases & Descriptions:

Name: Lupus Erythematosus 9 41 11 43 60
Lupus 9 41 32 3
Subacute Cutaneous Lupus 41 60
Disseminated Lupus Erythematosus 41
Lupus Erythematosus, Systemic 60
Systemic Lupus Erythematosus 41
 
Lupus Erythematosus, Discoid 60
Lupus Erythematosus Nos 9
Lupus Vulgaris 60
Discoid Lupus 41
Sle 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases, Bone diseases


External Ids:

Disease Ontology9 DOID:8857
ICD9CM27 695.4
NCIt38 C27153
ICD1025 L93

Related Diseases for Lupus Erythematosus

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Diseases in the Lupus Erythematosus family:

Systemic Lupus Erythematosus Systemic Lupus Erythematosus 9
Systemic Lupus Erythematosus 1 Systemic Lupus Erythematosus 2
Systemic Lupus Erythematosus 16 Systemic Lupus Erythematosus 10
Dnase1-Related Susceptibility to Systemic Lupus Erythematosus Cr2-Related Susceptibility to Systemic Lupus Erythematosus
Autosomal Recessive Systemic Lupus Erythematosus

Diseases related to Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 902)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus33.5FCGR2B, DNASE1
2subacute cutaneous lupus erythematosus32.7CALR, TRIM21
3arthritis32.2PTPN22, FCGR2B, FCGR3A, C3, CTLA4
4nephritis32.1C4A, C3, FCGR3A
5vasculitis32.0C3, CTLA4, TRIM21
6lupus nephritis31.9FCGR3A, DNASE1, PDCD1
7connective tissue disease31.7PTPN22, FCGR2B, DNASE1, C3, CTLA4, TRIM21
8congenital heart block31.7SSB, CALR, TRIM21
9rheumatic disease31.6TRIM21
10thyroiditis31.6CTLA4, PTPN22
11rheumatoid arthritis31.6TNFRSF13C, PTPN22, FCGR2B, FCRL3, FCGR3A, STAT4
12complement deficiency31.5C4A, C3
13sjogren's syndrome31.5TRIM21, CALR, SSB
14common variable immunodeficiency31.3TNFRSF13C
15psoriasis31.3CTLA4, FCGR3A, PTPN22, TLR5
16systemic scleroderma31.2CTLA4, SSB, PTPN22
17celiac disease31.1CTLA4, CALR, PTPN22
18b-cell lymphomas31.1CR2, FCGR2B, TNFRSF13C
19primary biliary cirrhosis31.1CTLA4, PDCD1, CALR
20influenza31.0TLR5, DNASE1, CALR
21graves' disease30.8PTPN22, FCRL3, CTLA4
22inflammatory bowel disease30.6CTLA4, STAT4, PTPN22, TLR5
23ulcerative colitis30.3CTLA4, STAT4, TLR5
24chronic lymphocytic leukemia30.1TNFRSF13C, CR2, CTLA4
25cutaneous lupus erythematosus11.4
26discoid lupus erythematosus11.4
27pediatric systemic lupus erythematosus11.0
28antiphospholipid syndrome11.0
29panniculitis10.9
30endotheliitis10.9
31myelitis10.9
32neonatal lupus erythematosus10.9
33drug-induced lupus erythematosus10.9
34lupus erythematosus tumidus10.9
35lupus erythematosus panniculitis10.9
36scleroderma10.8
37atherosclerosis10.8
38protein-losing enteropathy10.8
39mixed connective tissue disease10.8
40purpura10.8
41transverse myelitis10.8
42cerebritis10.8
43glomerulonephritis10.8
44retinitis10.8
45dermatomyositis10.8
46hepatitis10.7
47chilblain lupus10.7
48dermatitis10.7
49porphyria10.7
50lymphopenia10.7

Graphical network of the top 20 diseases related to Lupus Erythematosus:



Diseases related to lupus erythematosus

Symptoms for Lupus Erythematosus

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Drugs & Therapeutics for Lupus Erythematosus

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Genetic Tests for Lupus Erythematosus

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Anatomical Context for Lupus Erythematosus

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MalaCards organs/tissues related to Lupus Erythematosus:

31
T cells, Skin, B cells, Heart, Lung, Kidney, Endothelial, Testes, Neutrophil, Brain, Monocytes, Bone, Thyroid, Liver, Breast, Bone marrow, Pituitary, Myeloid, Salivary gland, Whole blood, Spleen, Nk cells, Eye, Spinal cord, Colon, Placenta, Prostate, Smooth muscle, Skeletal muscle, Thymus, Uterus, Temporal lobe, Pineal

Animal Models for Lupus Erythematosus or affiliated genes

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Publications for Lupus Erythematosus

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Articles related to Lupus Erythematosus:

(show top 50)    (show all 5967)
idTitleAuthorsYear
1
Beneficial effect of hydroxychloroquine on cutaneous lupus erythematosus in a Japanese girl. (24617496)
2014
2
Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation. (25385499)
2014
3
T lymphocyte apoptosis in systemic lupus erythematosus patients. (24106599)
2013
4
Vitamin d deficiency and systemic lupus erythematosus: cause or consequence? (23904929)
2013
5
Association of RANTES and MBL gene polymorphisms with systemic lupus erythematosus: a meta-analysis. (23065234)
2013
6
Factors that determine body composition of female systemic lupus erythematosus (SLE) patients in Sri Lanka: a comparative study using dual-energy x-ray absorptiometry. (23861026)
2013
7
Diffuse dystrophic calcinosis cutis of the scalp in a patient with scalp discoid lupus erythematosus and systemic lupus erythematosus. (23426499)
2013
8
Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus. (24379124)
2013
9
Irritable bowel syndrome-type symptoms in female patients with mild systemic lupus erythematosus: frequency, related factors and quality of life. (24112121)
2013
10
Infliximab-induced discoid lupus erythematosus. (23554040)
2013
11
Polimorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus. (22235789)
2012
12
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
13
Severe symmetrical facial lipoatrophy in a patient with discoid lupus erythematosus. (22976708)
2012
14
Neonatal lupus erythematosus and its clinical variability. (22606966)
2012
15
Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus. (21383913)
2011
16
Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus. (21163672)
2011
17
Squamous cell carcinoma arising in discoid lupus erythematosus lesions of the ears infected with human papillomavirus. (21140928)
2010
18
Histopathologic characteristics of neonatal cutaneous lupus erythematosus: description of five cases and literature review. (19515045)
2009
19
Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression. (18625638)
2008
20
HLA-DRB1 alleles in juvenile-onset systemic lupus erythematosus: renal histologic class correlations. (17401504)
2007
21
Preliminary clinical measurement of the expression of B-cell activating factor in Chinese systemic lupus erythematosus patients. (17506477)
2007
22
Circulating proangiogenic molecules PIGF, SDF-1 and sVCAM-1 in patients with systemic lupus erythematosus. (17964973)
2007
23
Squamous cell carcinoma in black patients with discoid lupus erythematosus. (17330632)
2006
24
Subacute cutaneous lupus erythematosus: 25-year evolution of a prototypic subset (subphenotype) of lupus erythematosus defined by characteristic cutaneous, pathological, immunological, and genetic findings. (15990071)
2005
25
Expression of p53 and apoptosis in discoid lupus erythematosus. (16100773)
2005
26
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
27
The A/T mutation in exon 2 of the DNASE1 gene is not present in Tunisian patients with systemic lupus erythematosus or in healthy subjects. (14613299)
2003
28
Lupus erythematosus tumidus in childhood. Report of 3 patients. (12920372)
2003
29
Drug-induced lupus erythematosus by amiodarone. (11926860)
2002
30
Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. (12145745)
2002
31
Subacute cutaneous lupus erythematosus associated with hepatocellular carcinoma. (11309033)
2001
32
Coronary artery disease in systemic lupus erythematosus: A review of the literature. (11404827)
2001
33
Serum levels of angiogenic cytokines in systemic lupus erythematosus and their correlation with disease activity. (11566625)
2001
34
Hypercalcaemia in systemic lupus erythematosus. (11346230)
2001
35
Nocardiosis in patients with systemic lupus erythematosus. The Singapore Lupus Study Group. (10813308)
2000
36
Chronic intestinal pseudo-obstruction in systemic lupus erythematosus due to intestinal smooth muscle myopathy. (10981652)
2000
37
Questions answered and a $1 million question raised concerning lupus erythematosus tumidus: is routine laboratory surveillance testing during treatment with hydroxychloroquine for skin disease really necessary. (10926741)
2000
38
The cutaneous pathology associated with seropositivity for antibodies to SSA (Ro): a clinicopathologic study of 23 adult patients without subacute cutaneous lupus erythematosus. (10218672)
1999
39
Echocardiography in systemic lupus erythematosus. (9863896)
1998
40
Animal models of cutaneous lupus erythematosus and lupus erythematosus photosensitivity. (9061668)
1997
41
Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease. (9202064)
1997
42
Human parvovirus infection: rheumatic manifestations, angioedema, C1 esterase inhibitor deficiency, ANA positivity, and possible onset of systemic lupus erythematosus. (8823689)
1996
43
Elevated soluble CD27 levels in serum of patients with systemic lupus erythematosus. (8938100)
1996
44
Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus. (7706484)
1995
45
Childhood discoid lupus erythematosus. (8170860)
1994
46
Activation markers on peripheral blood T cells from patients with active or inactive systemic lupus erythematosus. Correlation with proliferative responses and production of IL-2. (1812897)
1991
47
Systemic lupus erythematosus and miliary tuberculosis in a prepubertal girl--a case report. (2152059)
1990
48
Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. (3861745)
1985
49
Oral discoid lupus erythematosus. I. The validity of previous histopathologic diagnostic criteria. (6582433)
1984
50
Concurrent localized scleroderma and discoid lupus erythematosus. Cutaneous 'mixed' or 'overlap' syndrome. (718182)
1978

Variations for Lupus Erythematosus

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Expression for genes affiliated with Lupus Erythematosus

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Search GEO for disease gene expression data for Lupus Erythematosus.

Pathways for genes affiliated with Lupus Erythematosus

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Pathways related to Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1PTPN22, PDCD1, CTLA4
210.0BANK1, CR2, FCGR2B
310.0C3, FCGR3A, FCGR2B
410.0C3, FCGR3A, FCGR2B
5
Show member pathways
10.0TLR5, FCGR2B, STAT4, CR2
6
Show member pathways
9.9TNFRSF13C, CALR, CTLA4, C4A
7
Show member pathways
9.9TLR5, FCGR3A, STAT4, C3
89.9C4B, C4A, C3, C1QA
9
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.9CTLA4, CR2, PDCD1, FCGR2B
10
Show member pathways
9.9C4A, C3, FCGR3A, C1QA
119.9FCGR2B, FCGR3A, C3, CALR
12
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.8C1QA, TLR5, STAT4, C3, CALR
13
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.8C1QA, C3, CR2, C4A, C4B
14
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.8C1QA, C3, CR2, C4A, C4B
159.6C4B, C4A, C3, FCGR3A, FCGR2B, C1QA
16
Show member pathways
9.5FCGR2B, FCGR3A, C3, CALR, PDCD1, CTLA4
17
Show member pathways
9.4C1QA, FCGR3A, SSB, C3, C4A, C4B

Compounds for genes affiliated with Lupus Erythematosus

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Sources:
49PharmGKB, 12DrugBank, 43Novoseek, 28IUPHAR, 24HMDB
See all sources

Compounds related to Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 30)
idCompoundScoreTop Affiliating Genes
1tositumomab49 1211.4C1QA, FCGR2B, FCGR3A
2ibritumomab49 1211.4FCGR3A, FCGR2B, C1QA
3alefacept43 1211.4C1QA, FCGR2B, FCGR3A
4bevacizumab49 1211.3FCGR3A, FCGR2B, C1QA
5efalizumab43 1211.3FCGR3A, FCGR2B, C1QA
6daclizumab43 1211.3C1QA, FCGR2B, FCGR3A
7basiliximab43 1211.3FCGR3A, FCGR2B, C1QA
8natalizumab43 1211.3C1QA, FCGR2B, FCGR3A
9alemtuzumab43 1211.3C1QA, FCGR2B, FCGR3A
10gemtuzumab ozogamicin49 43 1212.3FCGR3A, FCGR2B, C1QA
11adalimumab43 49 1212.3C1QA, FCGR2B, FCGR3A
12abciximab43 1211.3FCGR3A, FCGR2B, C1QA
13allergens4310.3CTLA4, PDCD1, STAT4
14aurintricarboxylic acid4310.3DNASE1L3, DNASE1
15cetuximab43 49 1212.2FCGR3A, FCGR2B, C1QA
16etanercept43 49 1212.2FCGR3A, FCGR2B, C1QA
17rituximab43 49 1212.2C1QA, FCGR2B, FCGR3A, CTLA4
18trastuzumab43 49 1212.2C1QA, FCGR2B, FCGR3A
19agarose4310.2DNASE1, C3, C4A, C4B
20steroid4310.0C3, CALR, CTLA4, C4A, C4B
21dexamethasone43 49 28 1213.0CTLA4, CALR, C3, DNASE1, STAT4
22zinc43 2410.9DNASE1, CALR, CR2, C4B, TRIM21
23heparin43 28 24 1212.9C4B, CALR, C3, DNASE1
24mannose439.9CALR, C3, FCGR3A
25phosphatidylinositol439.9TLR5, FCGR2B, FCGR3A, STAT4, C3, CR2
26threonine439.8CALR, CR2, CTLA4, C4A, C4B
27serine439.7C4B, FCGR2B, STAT4, DNASE1, C3, CALR
28tyrosine439.6TLR5, PTPN22, FCGR2B, FCGR3A, STAT4, CALR
29estrogen439.5FCGR2B, DNASE1, C3, CR2, CTLA4
30calcium43 49 24 1212.4C1QA, TNFRSF13C, FCGR2B, FCGR3A, DNASE1, DNASE1L3

GO Terms for genes affiliated with Lupus Erythematosus

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Cellular components related to Lupus Erythematosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:007256210.1C4B, C4A, C3
2external side of plasma membraneGO:00098979.6CTLA4, TNFRSF13C, FCGR3A, CALR, PDCD1, CR2
3extracellular regionGO:00055769.2C1QA, FCGR3A, DNASE1, C3, CALR, C4A
4plasma membraneGO:00058868.9TLR5, FCGR2B, FCRL3, FCGR3A, C3, PDCD1

Biological processes related to Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell cycleGO:004578710.2TRIM21, CALR
2regulation of complement activationGO:003044910.2C3, C4A, C4B
3complement activationGO:000695610.1C4B, C4A, C3, C1QA
4T cell costimulationGO:003129510.1CTLA4, PDCD1, TNFRSF13C
5complement activation, classical pathwayGO:000695810.0C4B, C4A, CR2, C3, C1QA
6inflammatory responseGO:000695410.0TLR5, C3, C4A, C4B
7positive regulation of phagocytosisGO:00507669.9CALR, C3
8regulation of immune responseGO:00507769.9C3, FCGR3A, FCGR2B
9immune responseGO:00069559.9FCGR2B, FCGR3A, C3, CR2, CTLA4
10innate immune responseGO:00450879.6C1QA, TLR5, FCGR3A, C3, CR2, C4A

Molecular functions related to Lupus Erythematosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:000486610.0C4B, C4A, C3
2IgG bindingGO:00198649.8FCGR3A, FCGR2B
3protein bindingGO:00055159.0PTPN22, FCGR2B, SSB, DNASE1, C3, CALR

Products for genes affiliated with Lupus Erythematosus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Lupus Erythematosus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet