SLE
MCID: LPS004
MIFTS: 75

Lupus Erythematosus (SLE) malady

Genetic diseases, Rare diseases, Skin diseases, Immune diseases, Bone diseases categories

Summaries for Lupus Erythematosus

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MedlinePlus:33 If you have lupus, your immune system attacks healthy cells and tissues by mistake. this can damage your joints, skin, blood vessels and organs. there are many kinds of lupus. the most common type, systemic lupus erythematosus, affects many parts of the body. discoid lupus causes a rash that doesn't go away. subacute cutaneous lupus causes sores after being out in the sun. another type can be caused by medication. neonatal lupus, which is rare, affects newborns. anyone can get lupus, but women are most at risk. lupus is also more common in african american, hispanic, asian and native american women. the cause of lupus is not known. lupus has many symptoms. some common ones are joint pain or swelling muscle pain fever with no known cause fatigue red rashes, often on the face (also called the "butterfly rash") there is no one test to diagnose lupus, and it may take months or years to make the diagnosis. there is no cure for lupus, but medicines and lifestyle changes can help control it. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Lupus Erythematosus, also known as lupus, is related to systemic lupus erythematosus and subacute cutaneous lupus erythematosus. An important gene associated with Lupus Erythematosus is TLR5 (toll-like receptor 5), and among its related pathways are CD28 co-stimulation and B Cell Receptor Signaling Pathway. The drugs chloroquine and thalidomide and the compounds tositumomab and ibritumomab have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and b cells, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

NIH Rare Diseases:42 Lupus is an autoimmune disease. it can affect almost every organ in the body. symptoms of lupus can be very mild to life threatening. there are three types of lupus; systemic lupus erythematosus, discoid lupus, and drug-induced lupus. treatment of lupus depends on the severity of the condition and what parts of the body are affected. treatment may include acetaminophen, ibuprofen, antimalarial drugs, anti-inflammatory steroids, and/or immunosuppressive drugs. last updated: 3/11/2010

CDC:4 Systemic Lupus Erythematosus is an autoimmune disease in which the immune system produces antibodies to cells within the body leading to widespread inflammation and tissue damage. The causes of SLE are unknown but are believed to be linked to genetic, environmental, and hormonal factors. SLE may be characterized by periods of illness and remissions. SLE has a variety of clinical manifestations and can affect joints, skin, brain, lungs, kidneys, and blood vessels. People with SLE may experience fatigue, pain or swelling in joints, skin rashes, and fevers. A team approach in treating lupus is often warranted due to the number of organ systems involved.

Wikipedia:64 Lupus erythematosus is a name given to a collection of autoimmune diseases in which the human immune... more...

Aliases & Classifications for Lupus Erythematosus

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Lupus Erythematosus, Aliases & Descriptions:

Name: Lupus Erythematosus 9 42 11 44 61
Lupus 9 42 33
Disseminated Lupus Erythematosus 42 61
Subacute Cutaneous Lupus 42 61
Lupus Erythematosus, Systemic 61
Systemic Lupus Erythematosus 42
 
Lupus Erythematosus, Discoid 61
Lupus Erythematosus Nos 9
Discoid Lupus 42
Sle Nos 61
Sle 42


Classifications:



External Ids:

Disease Ontology9 DOID:8857
ICD9CM28 695.4
NCIt39 C27153
ICD1026 L93, L93.0

Related Diseases for Lupus Erythematosus

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Diseases in the Systemic Lupus Erythematosus family:

lupus erythematosus Dnase1-Related Susceptibility to Systemic Lupus Erythematosus
Cr2-Related Susceptibility to Systemic Lupus Erythematosus Systemic Lupus Erythematosus 14
Systemic Lupus Erythematosus 9 Systemic Lupus Erythematosus 1
Systemic Lupus Erythematosus 2 Systemic Lupus Erythematosus 16
Systemic Lupus Erythematosus 3 Systemic Lupus Erythematosus 13
Systemic Lupus Erythematosus 10 Systemic Lupus Erythematosus 12
Systemic Lupus Erythematosus 4 Systemic Lupus Erythematosus 5
Systemic Lupus Erythematosus 7 Systemic Lupus Erythematosus 8

Diseases related to Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 958)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus33.5DNASE1, FCGR2B
2subacute cutaneous lupus erythematosus32.7CALR, TRIM21
3arthritis32.2CTLA4, C3, PTPN22, FCGR3A, FCGR2B
4nephritis32.1C4A, C3, FCGR3A
5vasculitis32.0TRIM21, C3, CTLA4
6lupus nephritis31.9FCGR3A, DNASE1, PDCD1
7connective tissue disease31.7TRIM21, CTLA4, PTPN22, FCGR2B, DNASE1, C3
8congenital heart block31.7CALR, SSB, TRIM21
9rheumatic disease31.6TRIM21
10thyroiditis31.6PTPN22, CTLA4
11rheumatoid arthritis31.6FCGR2B, TRIM21, FCRL3, FCGR3A, STAT4, CALR
12complement deficiency31.5C4A, C3
13vitiligo31.5CTLA4, C4B, PTPN22
14sjogren's syndrome31.5CALR, SSB, TRIM21
15common variable immunodeficiency31.3TNFRSF13C
16systemic scleroderma31.3CTLA4, PTPN22, SSB
17diabetes mellitus31.3C3, CTLA4, PTPN22, CALR
18multiple sclerosis31.2C4B, TNFRSF13C, PTPN22, STAT4, CTLA4, PDCD1
19psoriasis31.2PTPN22, CTLA4, FCGR3A, TLR5
20primary biliary cirrhosis31.1CTLA4, PDCD1, CALR
21celiac disease31.1CALR, PTPN22, CTLA4
22b-cell lymphomas31.1FCGR2B, TNFRSF13C, CR2
23influenza31.0CALR, TLR5, DNASE1
24sepsis30.9FCGR3A, C4A, C3, TLR5
25type 1 diabetes mellitus30.9C3, PTPN22, C4A, CTLA4, PDCD1
26graves' disease30.8CTLA4, FCRL3, PTPN22
27inflammatory bowel disease30.6STAT4, PTPN22, TLR5, CTLA4
28burkitt's lymphoma30.3FCGR2B, PDCD1, STAT4, DNASE1, CTLA4, CR2
29ulcerative colitis30.3TLR5, STAT4, CTLA4
30chronic lymphocytic leukemia30.1CTLA4, CR2, TNFRSF13C
31non-hodgkin lymphoma29.9CR2, FCGR3A, TNFRSF13C
32cutaneous lupus erythematosus11.4
33discoid lupus erythematosus11.4
34pediatric systemic lupus erythematosus11.0
35antiphospholipid syndrome11.0
36bullous systemic lupus erythematosus10.9
37panniculitis10.9
38systemic lupus erythematosus, association with10.9
39endotheliitis10.9
40myelitis10.9
41lupus erythematosus panniculitis10.9
42neonatal lupus erythematosus10.9
43drug-induced lupus erythematosus10.8
44lupus erythematosus tumidus10.8
45scleroderma10.8
46atherosclerosis10.8
47protein-losing enteropathy10.8
48mixed connective tissue disease10.8
49purpura10.8
50transverse myelitis10.8

Graphical network of the top 20 diseases related to Lupus Erythematosus:



Diseases related to lupus erythematosus

Symptoms for Lupus Erythematosus

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Drugs & Therapeutics for Lupus Erythematosus

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Genetic Tests for Lupus Erythematosus

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Anatomical Context for Lupus Erythematosus

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MalaCards organs/tissues related to Lupus Erythematosus:

32
T cells, Skin, B cells, Heart, Lung, Kidney, Endothelial, Testes, Brain, Neutrophil, Monocytes, Bone, Thyroid, Liver, Bone marrow, Breast, Pituitary, Myeloid, Whole blood, Spleen, Nk cells, Spinal cord, Salivary gland, Placenta, Prostate, Smooth muscle, Skeletal muscle, Eye, Thymus, Colon, Uterus, Temporal lobe, Pineal

Animal Models for Lupus Erythematosus or affiliated genes

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Publications for Lupus Erythematosus

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Articles related to Lupus Erythematosus:

(show top 50)    (show all 5866)
idTitleAuthorsYear
1
Beneficial effect of hydroxychloroquine on cutaneous lupus erythematosus in a Japanese girl. (24617496)
2014
2
Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation. (25385499)
2014
3
T lymphocyte apoptosis in systemic lupus erythematosus patients. (24106599)
2013
4
Vitamin d deficiency and systemic lupus erythematosus: cause or consequence? (23904929)
2013
5
Association of RANTES and MBL gene polymorphisms with systemic lupus erythematosus: a meta-analysis. (23065234)
2013
6
Factors that determine body composition of female systemic lupus erythematosus (SLE) patients in Sri Lanka: a comparative study using dual-energy x-ray absorptiometry. (23861026)
2013
7
Diffuse dystrophic calcinosis cutis of the scalp in a patient with scalp discoid lupus erythematosus and systemic lupus erythematosus. (23426499)
2013
8
Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus. (24379124)
2013
9
Irritable bowel syndrome-type symptoms in female patients with mild systemic lupus erythematosus: frequency, related factors and quality of life. (24112121)
2013
10
Infliximab-induced discoid lupus erythematosus. (23554040)
2013
11
Polimorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus. (22235789)
2012
12
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
13
Severe symmetrical facial lipoatrophy in a patient with discoid lupus erythematosus. (22976708)
2012
14
Neonatal lupus erythematosus and its clinical variability. (22606966)
2012
15
Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus. (21383913)
2011
16
Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus. (21163672)
2011
17
Squamous cell carcinoma arising in discoid lupus erythematosus lesions of the ears infected with human papillomavirus. (21140928)
2010
18
Histopathologic characteristics of neonatal cutaneous lupus erythematosus: description of five cases and literature review. (19515045)
2009
19
Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression. (18625638)
2008
20
HLA-DRB1 alleles in juvenile-onset systemic lupus erythematosus: renal histologic class correlations. (17401504)
2007
21
Preliminary clinical measurement of the expression of B-cell activating factor in Chinese systemic lupus erythematosus patients. (17506477)
2007
22
Circulating proangiogenic molecules PIGF, SDF-1 and sVCAM-1 in patients with systemic lupus erythematosus. (17964973)
2007
23
Squamous cell carcinoma in black patients with discoid lupus erythematosus. (17330632)
2006
24
Subacute cutaneous lupus erythematosus: 25-year evolution of a prototypic subset (subphenotype) of lupus erythematosus defined by characteristic cutaneous, pathological, immunological, and genetic findings. (15990071)
2005
25
Expression of p53 and apoptosis in discoid lupus erythematosus. (16100773)
2005
26
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
27
The A/T mutation in exon 2 of the DNASE1 gene is not present in Tunisian patients with systemic lupus erythematosus or in healthy subjects. (14613299)
2003
28
Lupus erythematosus tumidus in childhood. Report of 3 patients. (12920372)
2003
29
Drug-induced lupus erythematosus by amiodarone. (11926860)
2002
30
Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. (12145745)
2002
31
Subacute cutaneous lupus erythematosus associated with hepatocellular carcinoma. (11309033)
2001
32
Coronary artery disease in systemic lupus erythematosus: A review of the literature. (11404827)
2001
33
Serum levels of angiogenic cytokines in systemic lupus erythematosus and their correlation with disease activity. (11566625)
2001
34
Hypercalcaemia in systemic lupus erythematosus. (11346230)
2001
35
Nocardiosis in patients with systemic lupus erythematosus. The Singapore Lupus Study Group. (10813308)
2000
36
Chronic intestinal pseudo-obstruction in systemic lupus erythematosus due to intestinal smooth muscle myopathy. (10981652)
2000
37
Questions answered and a $1 million question raised concerning lupus erythematosus tumidus: is routine laboratory surveillance testing during treatment with hydroxychloroquine for skin disease really necessary. (10926741)
2000
38
The cutaneous pathology associated with seropositivity for antibodies to SSA (Ro): a clinicopathologic study of 23 adult patients without subacute cutaneous lupus erythematosus. (10218672)
1999
39
Echocardiography in systemic lupus erythematosus. (9863896)
1998
40
Animal models of cutaneous lupus erythematosus and lupus erythematosus photosensitivity. (9061668)
1997
41
Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease. (9202064)
1997
42
Human parvovirus infection: rheumatic manifestations, angioedema, C1 esterase inhibitor deficiency, ANA positivity, and possible onset of systemic lupus erythematosus. (8823689)
1996
43
Elevated soluble CD27 levels in serum of patients with systemic lupus erythematosus. (8938100)
1996
44
Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus. (7706484)
1995
45
Childhood discoid lupus erythematosus. (8170860)
1994
46
Activation markers on peripheral blood T cells from patients with active or inactive systemic lupus erythematosus. Correlation with proliferative responses and production of IL-2. (1812897)
1991
47
Systemic lupus erythematosus and miliary tuberculosis in a prepubertal girl--a case report. (2152059)
1990
48
Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. (3861745)
1985
49
Oral discoid lupus erythematosus. I. The validity of previous histopathologic diagnostic criteria. (6582433)
1984
50
Concurrent localized scleroderma and discoid lupus erythematosus. Cutaneous 'mixed' or 'overlap' syndrome. (718182)
1978

Variations for Lupus Erythematosus

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Expression for genes affiliated with Lupus Erythematosus

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Expression patterns in normal tissues for genes affiliated with Lupus Erythematosus

Search GEO for disease gene expression data for Lupus Erythematosus.

Pathways for genes affiliated with Lupus Erythematosus

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Pathways related to Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1PDCD1, PTPN22, CTLA4
210.0FCGR2B, BANK1, CR2
310.0FCGR3A, C3, FCGR2B
410.0C3, FCGR3A, FCGR2B
5
Show member pathways
10.0FCGR2B, CR2, STAT4, TLR5
6
Show member pathways
9.9C4A, CALR, TNFRSF13C, CTLA4
7
Show member pathways
9.9FCGR3A, STAT4, TLR5, C3
89.9C4A, C1QA, C4B, C3
9
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.9CTLA4, CR2, PDCD1, FCGR2B
10
Show member pathways
9.9C4A, C3, FCGR3A, C1QA
119.9CALR, FCGR2B, FCGR3A, C3
12
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.8TLR5, C3, STAT4, C1QA, CALR
13
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.8C4A, CR2, C1QA, C4B, C3
14
Show member pathways
Immune response Alternative complement pathway59
Immune response Lectin Induced complement pathway59
Immune response Classic complement pathway59
9.8C4B, C1QA, C3, CR2, C4A
159.6FCGR2B, C1QA, FCGR3A, C3, C4A, C4B
16
Show member pathways
9.5C3, FCGR2B, FCGR3A, CALR, TRIM21, CTLA4
17
Show member pathways
9.4C1QA, FCGR3A, SSB, C3, C4A, C4B

Compounds for genes affiliated with Lupus Erythematosus

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Sources:
50PharmGKB, 12DrugBank, 44Novoseek, 29IUPHAR, 25HMDB
See all sources

Compounds related to Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1tositumomab50 1211.4FCGR3A, FCGR2B, C1QA
2ibritumomab50 1211.4FCGR3A, FCGR2B, C1QA
3alefacept44 1211.4C1QA, FCGR2B, FCGR3A
4bevacizumab50 1211.3FCGR3A, C1QA, FCGR2B
5efalizumab44 1211.3C1QA, FCGR2B, FCGR3A
6daclizumab44 1211.3FCGR3A, FCGR2B, C1QA
7basiliximab44 1211.3FCGR3A, FCGR2B, C1QA
8natalizumab44 1211.3FCGR2B, FCGR3A, C1QA
9alemtuzumab44 1211.3FCGR3A, FCGR2B, C1QA
10gemtuzumab ozogamicin50 44 1212.3FCGR2B, C1QA, FCGR3A
11adalimumab44 50 1212.3FCGR2B, C1QA, FCGR3A
12abciximab44 1211.3FCGR2B, C1QA, FCGR3A
13allergens4410.3STAT4, CTLA4, PDCD1
14aurintricarboxylic acid4410.3DNASE1, DNASE1L3
15cetuximab44 50 1212.2FCGR3A, FCGR2B, C1QA
16etanercept44 50 1212.2FCGR2B, C1QA, FCGR3A
17rituximab44 50 1212.2FCGR3A, CTLA4, C1QA, FCGR2B
18trastuzumab44 50 1212.2FCGR3A, C1QA, FCGR2B
19agarose4410.2DNASE1, C3, C4A, C4B
20steroid4410.0C4A, CTLA4, CALR, C3, C4B
21dexamethasone44 50 29 1213.0C3, STAT4, DNASE1, CALR, CTLA4
22zinc44 2510.9DNASE1, C4B, TRIM21, CALR, CR2
23heparin44 29 25 1212.9C3, DNASE1, C4B, CALR
24mannose449.9CALR, FCGR3A, C3
25phosphatidylinositol449.9STAT4, FCGR3A, CR2, TLR5, CTLA4, FCGR2B
26threonine449.8C4B, CTLA4, C4A, CALR, CR2
27serine449.7CTLA4, FCGR2B, STAT4, DNASE1, C3, CALR
28tyrosine449.6CR2, PTPN22, CTLA4, PDCD1, CALR, STAT4
29estrogen449.5C3, FCGR2B, DNASE1, CR2, CTLA4
30calcium44 50 25 1212.4FCGR2B, FCGR3A, C4B, CTLA4, CR2, DNASE1

GO Terms for genes affiliated with Lupus Erythematosus

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Cellular components related to Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:07256210.1C4B, C4A, C3
2external side of plasma membraneGO:0098979.6CTLA4, TNFRSF13C, FCGR3A, CALR, PDCD1, CR2
3extracellular regionGO:0055769.2C1QA, FCGR3A, DNASE1, C3, CALR, C4A
4plasma membraneGO:0058868.9TLR5, FCGR2B, FCRL3, FCGR3A, C3, PDCD1

Biological processes related to Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell cycleGO:04578710.2TRIM21, CALR
2regulation of complement activationGO:03044910.2C3, C4A, C4B
3complement activationGO:00695610.1C4A, C3, C1QA, C4B
4T cell costimulationGO:03129510.1CTLA4, PDCD1, TNFRSF13C
5complement activation, classical pathwayGO:00695810.0C4A, CR2, C3, C1QA, C4B
6inflammatory responseGO:00695410.0C4B, TLR5, C3, C4A
7positive regulation of phagocytosisGO:0507669.9CALR, C3
8regulation of immune responseGO:0507769.9FCGR3A, C3, FCGR2B
9immune responseGO:0069559.9CR2, C3, FCGR3A, FCGR2B, CTLA4
10innate immune responseGO:0450879.6C3, TRIM21, C4B, C4A, CR2, C1QA

Molecular functions related to Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00486610.0C4B, C4A, C3
2IgG bindingGO:0198649.8FCGR3A, FCGR2B
3protein bindingGO:0055159.0PDCD1, TRIM21, C1QA, PTPN22, FCGR2B, SSB

Products for genes affiliated with Lupus Erythematosus

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Sources for Lupus Erythematosus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet