Lupus Erythematosus malady

MedlinePlus: If you have lupus, your immune system attacks healthy cells and tissues by mistake. this can damage your joints, skin, blood vessels and organs. there are many kinds of lupus. the most common type, systemic lupus erythematosus, affects many parts of the body. discoid lupus causes a rash that doesn't go away. subacute cutaneous lupus causes sores after being out in the sun. another type can be caused by medication. neonatal lupus, which is rare, affects newborns. anyone can get lupus, but women are most at risk. lupus is also more common in african american, hispanic, asian and native american women. the cause of lupus is not known. lupus has many symptoms. some common ones are joint pain or swelling muscle pain fever with no known cause red rashes, often on the face (also called the "butterfly rash") there is no one test to diagnose lupus, and it may take months or years to make the diagnosis. there is no cure for lupus, but medicines and lifestyle changes can help control it. nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Lupus Erythematosus, also known as lupus, is related to leukemia and pancreatitis. An important gene associated with Lupus Erythematosus is TLR5 (toll-like receptor 5), and among its related pathways are Systemic lupus erythematosus and Cytokine-cytokine receptor interaction. The compounds calcium and atp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and thymus, and related mouse phenotypes are cellular and homeostasis/metabolism.

CDC: Systemic Lupus Erythematosus is an autoimmune disease in which the immune system produces antibodies to cells within the body leading to widespread inflammation and tissue damage. The causes of SLE are unknown but are believed to be linked to genetic, environmental, and hormonal factors. SLE may be characterized by periods of illness and remissions. SLE has a variety of clinical manifestations and can affect joints, skin, brain, lungs, kidneys, and blood vessels. People with SLE may experience fatigue, pain or swelling in joints, skin rashes, and fevers. A team approach in treating lupus is often warranted due to the number of organ systems involved.²

Wikipedia: Lupus erythematosus is a name given to a collection of autoimmune diseases, in which the human immune...⁴⁴ more...

Aliases & Descriptions:

lupus erythematosus 6 8 32 43 lupus 6 23 lupus erythematosus nos (disorder) 6

lupus erythematosus (disorder) 6

Disease types for lupus erythematosus family:

lupus erythematosus (2) 6

Diseases related to lupus erythematosus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 997)

id	Related Disease	Score	Top Affiliating Genes
1	leukemia	140.2	PIK3CD, PIK3C2A, PIK3CG, SH2B3, COG2, NCF2
2	pancreatitis	101.2	PIK3CD, PIK3C2A, PIK3CG, LRP2, RGL2, NCF2
3	neuronitis	100.6	ZNF423, PIK3CD, PIK3C2A, PIK3CG, LRP2, NCF2
4	thyroiditis	97.4	PIGF, PIK3C2A, PIK3CG, LRP2, COG2, RECK
5	adenocarcinoma	90.1	PIK3C2A, PIK3CG, NCL, RECK, VWF, VTN
6	carcinoma	87.1	PIK3CD, PIGF, PIK3C2A, PIK3CG, LRP2, NCF2
7	atherosclerosis	85.1	PIK3C2A, PIK3CG, WDFY4, LRRC18, LRP2, COG2
8	fibrosis	84.2	PIK3CG, NCF2, RECK, RETN, VWF, VTN
9	diabetes mellitus	83.4	PIK3CD, PIK3C2A, PIK3CG, SH2B3, COG2, PDCD1
10	lymphocytic leukemia	82.8	PIK3CD, PIK3CG, NCL, PDCD1LG2, RECK, REL
11	anemia	77.9	PDCD1, VWF, PCNA, NBN, SELE, SELL
12	cerebritis	76.3	PIGF, PIK3C2A, PIK3CG, LRP2, COG2, CNTF
13	cholesterol	76.1	PIK3CD, PIK3C2A, PIK3CG, LRP2, COG2, NCF2
14	psoriasis	76.0	RETN, KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1, KIR2DL3
15	nephropathy	75.4	LRP2, COG2, PDCD1, RETN, VWF, VTN
16	pneumonia	73.4	PIK3C2A, COG2, VTN, RDBP, SFTPD, RBP4
17	hypertension	72.4	PIK3C2A, PIK3CG, SH2B3, COG2, REEP2, RETN
18	myocardial infarction	71.2	PIK3C2A, PIK3CG, SH2B3, COG2, PDCD1, RECK
19	nephritis	69.5	LRP2, PDCD1, VWF, VTN, PCNA, RBP4
20	sjogren's syndrome	67.3	PIK3C2A, PDCD1, RETN, KIR2DS3, KIR2DS5, KIR2DL1
21	retinitis	66.3	PIGF, PIK3C2A, PIK3CG, LRP2, CNBP, CNTF
22	immunodeficiency	65.6	PIK3CD, PDCD1, KIR3DL1, SELL, VIP, LMOD1
23	vasculitis	65.2	SH2B3, PDCD1, VWF, SELE, SELL, SELP
24	prostatitis	64.8	PIK3CD, PIK3C2A, PIK3CG, LRP2, NCL, PDCD1
25	sarcoidosis	64.5	PIK3C2A, KIR2DL3, VTN, SFTPD, BTNL2, SELE
26	purpura	63.9	RECK, VWF, SELE, SELP, SERPINC1, SERPINE1
27	pulmonary disease	63.5	PIK3CG, NCF2, RETN, VWF, SFTPD, PCNA
28	hypoxia	62.8	PIK3CD, PIGF, PIK3C2A, PIK3CG, RECK, VWF
29	osteoarthritis	62.1	PIK3CG, RETN, VTN, BTNL2, SERPINB2, SERPINE1
30	cystic fibrosis	61.7	PIK3CG, RECK, VWF, SFTPD, PCNA, RBP4
31	graves' disease	61.4	LRP2, PDCD1, PDCD1LG2, RETN, KIR2DS3, KIR2DS5
32	thrombosis	60.9	PIK3C2A, PIK3CG, COG2, RECK, RETN, VWF
33	glomerulonephritis	60.9	LRP2, VWF, VTN, PCNA, RBP4, SELP
34	gonococcal synovitis	59.4	PIK3CG, PDCD1, RECK, REL, RETN, CNBP
35	lupus nephritis	59.3	PDCD1, VWF, VTN, PCNA, RBP4, SELE
36	noonan syndrome	59.0	PIK3C2A, PIK3CG, RETN, VWF, PCNA, SELP
37	melanoma	58.9	PIK3CD, PIK3C2A, PIK3CG, NCL, PDCD1, PDCD1LG2
38	celiac disease	58.8	SH2B3, REL, KIR3DL1, KIR2DL5A, SELE, SELL
39	insulin resistance	58.3	PIK3CG, COG2, RETN, CNBP, CNTF, VWF
40	myopathy	55.2	PIK3C2A, CNBP, SELE, SEPN1, BRD2, VCAM1
41	blindness	55.1	PIK3C2A, PIK3CG, COG2, CNBP, CNTF, VWF
42	hepatocellular carcinoma	55.0	PIK3CD, PIK3CG, NCL, NCR3, PDCD1, PDCD1LG2
43	sepsis	54.9	RECK, RETN, VTN, SFTPD, RBP4, SELE
44	thrombocytopenia	54.7	PIK3C2A, RECK, VWF, SELE, SELL, SELP
45	spondylitis	54.5	PDCD1, PDCD1LG2, KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1
46	coronary heart disease	54.4	PIK3C2A, COG2, RETN, VWF, SELE, SELL
47	acute myocardial infarction	54.2	PIK3C2A, PIK3CG, COG2, RETN, CNTF, VWF
48	inflammatory bowel disease	53.7	RETN, SELE, SELL, SELP, SERPINA3, VIP
49	leishmaniasis	53.6	PIK3C2A, NCF2, LPA, MYD88, BMP6, CIITA
50	eclampsia	53.2	PIGF, KIR2DL4, KIR3DL1, VWF, SELE, SELL

Approved drugs:

Drug clinical trials:

Cell-based therapeutics:

MalaCards organs/tissues related to lupus erythematosus:

²²

MGI Mouse Phenotypes related to lupus erythematosus:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	58.0	ZNF423, PIK3CD, PIK3CG, LRP2, SH2B3, PDCD1
2	homeostasis/metabolism phenotype	MP:0005376	51.9	ZNF423, PIK3CD, PIK3C2A, PIK3CG, LRP2, PDCD1LG2
3	mortality/aging	MP:0010768	47.5	ZNF423, PIK3C2A, PDCD1, PDCD1LG2, RECK, REL
4	hematopoietic system phenotype	MP:0005397	39.9	SH2B3, PDCD1, PDCD1LG2, CNTF, RC3H1, PCNA
5	immune system phenotype	MP:0005387	38.3	PIK3CD, REL, CNTF, VWF, RC3H1, BTLA
6	growth/size phenotype	MP:0005378	36.0	ZNF423, PIK3C2A, PIK3CG, LRP2, RECK, REL
7	cardiovascular system phenotype	MP:0005385	33.6	PIK3CD, PIK3CG, PDCD1, RECK, REL, VWF
8	nervous system phenotype	MP:0003631	28.7	ZNF423, PDCD1, RECK, REL, CNBP, CNTF
9	normal phenotype	MP:0002873	28.0	ZNF423, VTN, RBP4, SELE, SEZ6L2, SERPING1
10	behavior/neurological phenotype	MP:0005386	27.3	ZNF423, LRP2, CNTF, RDX, NBN, SELE
11	tumorigenesis	MP:0002006	25.7	PDCD1LG2, NBN, SELL, SERPINE1, MYC, MYD88
12	integument phenotype	MP:0010771	25.0	PIK3CG, RECK, REL, SELP, LMNB1, MYC
13	digestive/alimentary phenotype	MP:0005381	24.1	LRP2, REL, VWF, VEGFA, VDR, VAV1
14	reproductive system phenotype	MP:0005389	22.0	RBP4, NBN, VIP, NAT1, VEGFA, VDR
15	vision/eye phenotype	MP:0005391	21.4	LRP2, PDCD1, CNBP, RBP4, SELE, SELP
16	liver/biliary system phenotype	MP:0005370	21.3	RECK, REL, RETN, RDX, RC3H1, SERPINC1
17	skeleton phenotype	MP:0005390	20.9	PIK3CD, PIK3CG, LRP2, RECK, REL, CNBP
18	muscle phenotype	MP:0005369	20.7	PIK3CG, PDCD1, CNTF, RBP4, SERPIND1, SERPINB2
19	renal/urinary system phenotype	MP:0005367	20.1	LRP2, PDCD1, RC3H1, SELP, SERPIND1, NAGLU
20	no phenotypic analysis	MP:0003012	20.1	PIK3CD, LRP2, PDCD1LG2, PCNA, VEGFA, VCAM1
21	embryogenesis phenotype	MP:0005380	18.6	RECK, REL, CNBP, NBN, SERPINC1, NAT1
22	respiratory system phenotype	MP:0005388	17.2	ZNF423, LRP2, REL, SFTPD, RC3H1, SELL
23	adipose tissue phenotype	MP:0005375	16.8	PIK3C2A, RETN, SERPINE1, BRD2, LPAR1, LPL
24	craniofacial phenotype	MP:0005382	15.6	ZNF423, LRP2, CNBP, NBN, NAGLU, LPAR1
25	endocrine/exocrine gland phenotype	MP:0005379	15.6	LRP2, NBN, SELL, BRD2, PATZ1, ZEB1
26	hearing/vestibular/ear phenotype	MP:0005377	15.2	LRP2, RDX, NAGLU, VDR, MYC, MYD88
27	limbs/digits/tail phenotype	MP:0005371	14.3	RECK, RC3H1, VEGFA, VDR, ZEB1, LEP
28	other phenotype	MP:0005395	13.1	SH2B3, RECK, SERPINH1, CLU, ZFP57, KDR

Articles related to lupus erythematosus:

(show top 50)    (show all 2205)

id	Title	Authors	Year	Affiliating Genes
1	ITGAM Arg77His Is Associated with Disease Susceptibil ity, Arthritis, and Renal Symptoms in Systemic Lupus Erythematosus Patients fro m a Sample of the Polish Population. (20666624)	WarchoA8 T.... JagodziA8ski P.P.	2010	ITGAM
2	Promoter insertion/deletion in the IRF5 gene is highl y associated with susceptibility to systemic lupus erythematosus in distinct po pulations, but exerts a modest effect on gene expression in peripheral blood mo nonuclear cells. (20080916)	LAPfgren S.E.... Kozyrev S.V.	2010	IRF5
3	Lack of association of FcgammaRIIIb polymorphisms wit h systemic lupus erythematosus: a meta-analysis. (20300756)	Yuan H.... Ye D.Q.	2010	FCGR3B
4	Association of estrogen and aromatase gene polymorphi sms with systemic lupus erythematosus. (20305046)	Wang J.... McAlindon T.E.	2010	ESR1, ESR2, CYP19A1
5	Functional monocyte chemoattractant protein-1 promote r -2518 polymorphism and systemic lupus erythematosus: a meta-analysis. (19941075)	Lee Y.H.... Song G.G.	2010	CCL2
6	Identification of MAMDC1 as a candidate susceptibilit y gene for systemic lupus erythematosus (SLE). (19997561)	Hellquist A.... Kere J.	2009	MDGA2
7	HLA in Portuguese systemic lupus erythematosus patien ts and their relation to clinical features. (19758202)	Vasconcelos C.... Martins B.	2009	HLA-DRB1
8	The informative value of determination of serum IL-1beta, IL-6, IFN-gamma in systemic lupus erythematosus (19338090)	Sozina A.V.... Shemerovskaia T.G.	2009	IL6, IFNG
9	Longitudinal expression of type I interferon responsi ve genes in systemic lupus erythematosus. (19762399)	Petri M.... Baechler E.	2009	IFNA1
10	Infectious antibodies in systemic lupus erythematosus patients. (19880558)	Berkun Y.... Shoenfeld Y.	2009	CD40LG
11	Association of three systemic lupus erythematosus susceptibility factors, PD-1.3A, C4AQ0, and low levels of mannan-binding lectin, with autoimmune manifestations in Icelandic multicase systemic lupus erythematosus families. (19035512)	Kristjansdottir H.... Steinsson K.	2008	MBL2, PDCD1, C4A
12	HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus. (18380776)	Rizzo R.... Baricordi O.R.	2008	HLA-G
13	Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (18174230)	Miyagawa H.... Horiuchi T.	2008	PTPRC, TGFBR2, FYN
14	Sequence analysis of TNFRSF13b, encoding TACI, in patients with systemic lupus erythematosus. (17464555)	Salzer U.... Grimbacher B.	2007	TNF, TNFSF13B, TNFRSF13B
15	Selected acute phase proteins and interleukin-6 in systemic lupus erythematosus patients treated with low doses of quinagolide. (17453721)	Hrycek A.... Scieszka J.	2007	IL6, PRL
16	Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosus. (16868980)	Brunner H.I.... Devarajan P.	2006	LCN2
17	Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus. (16729301)	Tripi L.M.... Kamboh M.I.	2006	PON1
18	Identification and characterization of an Xp22.33;Yp11.2 translocation causing a triplication of several genes of the pseudoautosomal region 1 in an XX male patient with severe systemic lupus erythematosus. (16575839)	Chagnon P.... Busque L.	2006	IL3RA
19	Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus. (16423064)	Lee J.H.... Chiang B.L.	2006	TNFRSF18
20	Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. (15657875)	Sigurdsson S.... Syvanen A.C.	2005	PTK2, TYK2, IRF5
21	Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease. (16052563)	Wu H.... Tsao B.P.	2005	PTPN22
22	Cartilage oligomeric matrix protein in serum in systemic lupus erythematosus and knee osteoarthritis. Preliminary communication. (15739097)	Wisl/owska M.... Jabl/onska B.	2005	COMP
23	Relationship of serum levels of HGF and MMP-9 with disease activity of patients with systemic lupus erythematosus (15269987)	Liu Y.... Zhang B.	2004	MMP9
24	Cyclophosphamide boluses induce micronuclei expression in buccal mucosa cells of patients with systemic lupus erythematosus independent of cytochrome P450 2D6 status. (15229952)	Aceves Avila F.J.... Ramos-Remus C.	2004	CYP2D6
25	Neuroendocrine dopaminergic regulation of prolactin release in systemic lupus erythematosus: a possible role of lymphocyte-derived prolactin. (14870917)	Mendez I.... Larrea F.	2004	PRL
26	Association of a programmed death 1 gene polymorphism with the development of rheumatoid arthritis, but not systemic lupus erythematosus. (15022318)	Lin S.C.... Chen C.J.	2004	PDCD1
27	Increased serum matrix metalloproteinase 9 levels in systemic lupus erythematosus patients with neuropsychiatric manifestations and brain magnetic resonance imaging abnormalities. (15022328)	Ainiala H.... Nikkari S.T.	2004	MMP9
28	Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans. (12508391)	Oates J.C.... Gilkeson G.S.	2003	NOS2
29	Cytokines in systemic lupus erythematosus, London, UK. (12823845)	Rahman A.	2003	TNF, IL10
30	Antibodies directed to protein S in patients with systemic lupus erythematosus: prevalence and clinical significance. (14515184)	Bertolaccini M.L.... Hughes G.R.	2003	PROS1
31	Contribution of the initial features of systemic lupus erythematosus to the clinical evolution and survival of a cohort of Mediterranean patients. (12922959)	BujA!n S.... Vilardell M.	2003	APOH
32	Stroke in systemic lupus erythematosus. (19810870)	Wierzbicki A.S.	2002	APOH
33	Aberrant expression of Fas ligand on anti-DNA autoantibody secreting B lymphocytes in patients with systemic lupus erythematosus: 'immune privilege'-like state of the autoreactive B cells. (12412192)	Nagafuchi H.... Suzuki N.	2002	FAS, FASLG
34	Brachial endothelial function is impaired in patients with systemic lupus erythematosus. (11842823)	Lima D.S.... Hatta F.H.	2002	APOH
35	Inherited complete factor I deficiency associated wit h systemic lupus erythematosus, higher susceptibility to infection and low leve ls of factor H. (11422911)	Amadei N.... Isaac L.	2001	CFI
36	Pyrexia and normal C-reactive protein (CRP) in patien ts with systemic lupus erythematosus: always consider the possibility of infect ion in febrile patients with systemic lupus erythematosus regardless of CRP lev els. (11285392)	Roy S.... Tan K.T.	2001	CRP
37	The lupus erythematosus cell phenomenon: comparative analysis of antichromatin antibody specificity in lupus erythematosus cell-positive and -negative sera. (10693884)	Schett G.... Smolen J.	2000	HIST2H2BE
38	Reduced in vitro production of interferon-gamma, interleukin-4 and interleukin-12 and increased production of interleukin-6, interleukin-10 and tumour necrosis factor-alpha in systemic lupus erythematosus. Weak correlations of cytokine production with disease activity. (10680750)	Jones B.M.... Wong R.W.	1999	TNF, IL6, IL4
39	MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera. (9538511)	McCurdy D.K.... Gatti R.A.	1998	MAGEB2
40	Polymorphisms of DMA and DMB genes in Japanese systemic lupus erythematosus. (9487257)	Takeuchi F.... Ito K.	1998	HLA-DMA, HLA-DMB
41	Hormone replacement therapy in postmenopausal women with systemic lupus erythematosus. (9458619)	Buyon J.P.	1998	SERPINE1
42	In situ expression of B7 and CD28 receptor families in skin lesions of patients with lupus erythematosus. (9153541)	Denfeld R.W.... Simon J.C.	1997	CD86, CD80
43	Recombinant human granulocyte colony stimulating fact or in patients with systemic lupus erythematosus associated neutropenia and ref ractory infections. (9375876)	Euler H.H.... Schwab U.M.	1997	CSF3
44	Major histocompatibility complex class II and C4 alleles in Mexican Americans with systemic lupus erythematosus. (7792766)	Reveille J.D.... Arnett F.C.	1995	CIITA
45	Upregulated expression and function of integrin adhesive receptors in systemic lupus erythematosus patients with vasculitis. (8254055)	Takeuchi T.... Abe T.	1993	ITGB2, ITGA4
46	Effect of total-body cold exposure on plasma concentrations of von Willebrand factor, endothelin-1 and thrombomodulin in systemic lupus erythematosus patients with or without Raynaud's phenomenon. (1337960)	Matsuda J.... Kazama M.	1992	VWF, EDN1, THBD
47	Peripheral catabolism of CR1 (the C3b receptor, CD35) on erythrocytes from healthy individuals and patients with systemic lupus erythematosus (SLE). (1531948)	Cohen J.H.... Kazatchkine M.D.	1992	CR1
48	Release of platelet-activating factor in systemic lupus erythematosus. (2354868)	Tetta C.... Camussi G.	1990	PLA2G7
49	Specificity and sensitivity of diluted aPTT and anticardiolipin antibodies towards thrombosis and miscarriages in patients with systemic lupus erythematosus. (2122546)	Ferro D.... Violi F.	1990	APOH
50	Analysis of autoantibodies to recombinant La (SS-B) peptides in systemic lupus erythematosus and primary Sjogren's syndrome. (1688881)	Bini P.... Elkon K.	1990	SSB

Genes related to lupus erythematosus according to GeneCards:

(show top 50)    (show all 1156)

id	Symbol	Description	Score	GeneCards Section Context
1	TLR5	toll-like receptor 5	11.1	Publications, Summaries
2	C4A	complement component 4A (Rodgers blood group)	11.1	Publications, Pathways & Interactions, Summaries
3	FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	11.1	Publications, Pathways & Interactions, Summaries
4	FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	11.1	Publications, Pathways & Interactions, Summaries
5	CR2	complement component (3d/Epstein Barr virus) receptor 2	11.1	Publications, Summaries
6	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.1	Publications, Summaries
7	TRIM21	tripartite motif containing 21	11.1	Publications, Pathways & Interactions, Summaries
8	CALR	calreticulin	11.1	Publications, Summaries
9	DNASE1	deoxyribonuclease I	11.1	Publications, Summaries
10	FASLG	Fas ligand (TNF superfamily, member 6)	11.1	Publications, Summaries
11	SLEB12	Systemic lupus erythematosus, susceptibility to, 12	11.1	Aliases & Descriptions
12	SLEB13	Systemic lupus erythematosus, susceptibility to, 13	11.1	Aliases & Descriptions
13	SLEB14	Systemic lupus erythematosus, susceptiblity to, 14	11.1	Aliases & Descriptions
14	SLEB5	Systemic lupus erythematosus, susceptibility to, 5	11.1	Aliases & Descriptions
15	SLEB7	Systemic lupus erythematosus, susceptibility to, 7	11.1	Aliases & Descriptions
16	SLEB8	Systemic lupus erythematosus, susceptibility to, 8	11.1	Aliases & Descriptions
17	SSB	Sjogren syndrome antigen B (autoantigen La)	11.1	Publications, Pathways & Interactions, Summaries
18	SLEB4	systemic lupus erythematosus, susceptibility to, 4	11.1	Publications, Aliases & Descriptions
19	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.1	Publications, Functions, Summaries
20	BANK1	B-cell scaffold protein with ankyrin repeats 1	11.1	Publications, Summaries
21	C3	complement component 3	11.1	Publications, Pathways & Interactions, Summaries
22	SLEB3	systemic lupus erythematosus susceptibility 3	11.1	Publications, Aliases & Descriptions
23	SLEN1	systemic lupus erythematosus with nephritis 1	11.1	Aliases & Descriptions, Publications
24	SLEN2	systemic lupus erythematosus with nephritis 2	11.1	Publications, Aliases & Descriptions
25	SLEN3	systemic lupus erythematosus with nephritis 3	11.1	Aliases & Descriptions, Publications
26	SLEB2	systemic lupus erythematosus susceptibility 2	11.1	Publications, Aliases & Descriptions
27	SLEB1	systemic lupus erythematosus susceptibility 1	11.1	Publications, Aliases & Descriptions
28	C1QA	complement component 1, q subcomponent, A chain	11.1	Publications, Pathways & Interactions, Summaries
29	C4B	complement component 4B (Chido blood group)	11.1	Publications, Pathways & Interactions, Summaries
30	FCRL3	Fc receptor-like 3	11.1	Publications, Summaries
31	STAT4	signal transducer and activator of transcription 4	11.1	Publications, Summaries
32	TNFRSF13C	tumor necrosis factor receptor superfamily, member 13C	11.1	Publications, Summaries
33	RPL7	ribosomal protein L7	11.1	Publications, Summaries
34	C5AR1	complement component 5a receptor 1	11.1	Publications, Summaries
35	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.1	Publications, Summaries
36	SLEH1	systemic lupus erythematosus with hemolytic anemia 1	11.1	Publications, Aliases & Descriptions
37	LOC100293534	complement C4-B-like	11.1	Publications, Summaries
38	GIMAP5	GTPase, IMAP family member 5	11.1	Publications, Summaries
39	C1QB	complement component 1, q subcomponent, B chain	11.1	Publications, Pathways & Interactions, Summaries
40	C1QC	complement component 1, q subcomponent, C chain	11.1	Publications, Pathways & Interactions, Summaries
41	FOXJ1	forkhead box J1	11.1	Publications, Summaries
42	DNASE1L3	deoxyribonuclease I-like 3	11.1	Publications, Summaries
43	FCN3	ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)	11.1	Publications, Summaries
44	SNRPB	small nuclear ribonucleoprotein polypeptides B and B1	11.1	Publications, Pathways & Interactions, Summaries
45	TNIP1	TNFAIP3 interacting protein 1	11.1	Publications, Summaries
46	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	11.1	Publications, Summaries
47	MAN2A1	mannosidase, alpha, class 2A, member 1	11.1	Publications, Summaries
48	XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	11.1	Orthologs, Summaries
49	CAT	catalase	11.1	Publications, Summaries
50	SLEV1	systemic lupus erythematosus, vitiligo-related 1	11.1	Aliases & Descriptions, Publications

Pathways related to lupus erythematosus according to GeneDecks:

(show top 50)    (show all 212)

id	Pathway	Score	Top Affiliating Genes
1	Systemic lupus erythematosus20	29.5	CD28, CD86, CD40LG, CD80, CD40, GRIN2A
2	Cytokine-cytokine receptor interaction20	25.2	CNTF, VEGFA, LIF, KDR, LEP, MPL
3	Tec Kinases Signaling36	25.1	VAV1, MYD88, BMP6, BDNF, BCL2, LCP2
4	Antioxidant Action of Vitamin-C36	24.8	NCF2, BMP6, LIF, BDNF, KDR, BCL2
5	ERK Signaling36	21.7	MYC, BMP6, RAF1, CHUK, ZAP70, LAMB1
6	JAK-STAT Pathway36	20.7	MYC, BMP6, RAF1, BDNF, KDR, BCL2
7	Akt Signaling36	20.6	PIK3CG, RAF1, LIF, CHUK, AXL, CD28
8	MAPK Family Pathway36	20.6	BMP6, RAF1, BDNF, KDR, BCL2, CHUK
9	Tuberculosis20	20.1	VDR, MYD88, RAF1, BCL2, CIITA, BAX
10	Glucocorticoid Receptor Signaling36	18.6	BMP6, BCL2, BAX, CEBPB, JUN, CDKN1A
11	TGF-Beta Pathway36	18.5	BMP6, BDNF, KDR, BCL2, BAX, JUN
12	Natural killer cell mediated cytotoxicity20	17.8	PIK3CD, PIK3CG, NCR3, KIR2DS3, KIR2DS5, KIR2DL1
13	NFAT in Immune Response36	17.8	BMP6, BDNF, KDR, CHUK, ZAP70, LCK
14	all-trans-Retinoic Acid Signaling in Brain36	17.6	BMP6, LIF, BCL2, BAX, CD2, CD80
15	Staphylococcus aureus infection20	17.4	SELP, CFB, CFH, CFI, ITGAL, ITGAM
16	Transendothelial Migration of Leukocytes36	17.3	NCF2, RDX, VCAM1, VAV1, SDC1, LAMB1
17	Jak-STAT signaling pathway20	17.2	PIK3CD, PIK3CG, CNTF, MYC, LEP, CISH
18	Lymphocyte Signaling3	16.8	NCF2, MYD88, RAG1, BLK, PAX5, CIITA
19	Toll-like receptor signaling pathway20	16.7	PIK3CD, PIK3CG, MYD88, CHUK, JUN, CD86
20	NF-KappaB Family Pathway36	16.7	REL, VAV1, MYD88, BMP6, BLK, BDNF
21	PGC1Alpha Pathway36	16.5	BMP6, BCL2, BAX, CD2, CD4, CD80
22	Immune response NFAT in immune response10	16.4	PIK3CD, REL, VAV1, CHUK, ZAP70, LCK
23	Endothelin-1 Signaling Pathway36	16.4	MYC, BMP6, RAF1, AXL, CD2, CD80
24	Allograft rejection20	16.3	CD28, CD86, CD40LG, CD80, CD40, GZMB
25	Signal transduction Activin A signaling regulation10	16.3	FOXG1, H2AFX, H2AFZ, H2BFS, H3F3A, H3F3B
26	NF-KappaB (p50-p65) Pathway36	16.3	MYD88, BMP6, BDNF, KDR, CHUK, UBD
27	Immune response Classic complement pathway10	16.1	SERPING1, CLU, CFI, CD59, CD93, CD55
28	Type I diabetes mellitus20	16.1	CD28, CD86, CD80, GZMB, INS, IL12A
29	IL-6 Pathway36	16.1	BMP6, RAF1, BAX, CD2, CD80, IL10
30	SOCS Pathway36	16.1	BMP6, BCL2, CISH, BAX, CD2, CD4
31	TRAF Pathway36	15.9	MYD88, CHUK, UBD, UBC, JUN, FOS
32	THC Differentiation Pathway36	15.8	CD28, CD86, IL10, IL10RA, IL10RB, IL12A
33	Pertussis20	15.8	SERPING1, MYD88, JUN, CD14, ITGAM, ITGB1
34	Nuclear Receptor Activation by Vitamin-A36	15.7	BMP6, BDNF, KDR, FLT1, GTF2H4, IL2
35	Immune response ICOS pathway in T-helper cell10	15.7	PIK3CD, PIK3CG, REL, VAV1, ZAP70, LCK
36	Viral myocarditis20	15.6	FYN, CD28, CD86, CD40LG, CD80, CD40
37	Immune response_T cell receptor signaling pathway41	15.2	REL, VAV1, RASGRP1, RAF1, CHUK, ZAP70
38	Malaria20	14.9	SELE, SELP, VCAM1, MYD88, SDC1, CD36
39	Immune response Lectin Induced complement pathway10	14.8	SERPING1, CLU, CFI, CD93, CD55, CD46
40	T cell receptor signaling pathway20	14.7	PIK3CD, PIK3CG, PDCD1, VAV1, RASGRP1, RAF1
41	TNF Superfamily Pathway36	14.7	CHUK, JUN, FOS, FADD, MAPK8, CASP3
42	14-3-3 Induced Apoptosis36	14.4	MYD88, BCL2, CHUK, YWHAB, JUN, FOS
43	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway41	14.0	REL, BCL2, BCL2A1, CHUK, CD40LG, CD40
44	Cytosolic DNA-sensing pathway20	13.9	CHUK, IRF3, IRF7, IL18, IL1B, IL33
45	CTL Mediated Apoptosis36	13.9	GZMB, FADD, CASP3, HLA-A, HLA-B, HLA-C
46	Asthma20	13.9	MS4A2, CD40LG, CD40, IL10, IL13, IL3
47	Immune response Role of DAP12 receptors in NK cells10	13.4	KIR2DL1, KIR2DL4, KIR2DS2, KIR2DL5A, KIR2DS1, KIR2DL2
48	Development NOTCH1-mediated pathway for NF-KB activity modulation10	13.2	REL, CHUK, IRAK1, IL1A, IL1R1, NFKB1
49	Immune response_Bacterial infections in normal airways41	13.1	REL, MYD88, CHUK, CD14, IRAK1, IRAK4
50	Bacterial infections in CF airways41	12.0	REL, SFTPD, MYD88, CHUK, IRAK1, IRAK4

Compounds related to lupus erythematosus according to GeneDecks:

(show top 50)    (show all 467)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	48.5	PIK3CD, PIK3C2A, COG2, NCF2, NCL, RECK
2	atp32	30.8	PIK3C2A, NCF2, NCL, RECK, CNBP, KIR3DL1
3	cholesterol32 9 18 9	32.5	PIK3C2A, LRP2, COG2, RECK, RETN, CNBP
4	creatinine32	27.4	RETN, VWF, PCNA, RBP4, SELE, SELL
5	superoxide32 18	27.3	PIK3C2A, NCF2, CNTF, SELL, SERPINB2, SERPINA3
6	lactate32	24.8	PIK3C2A, RECK, VWF, VTN, SFTPD, PCNA
7	paraffin32	20.8	VWF, PCNA, SELL, SERPINB2, SERPINA3, VEGFA
8	indomethacin32 9 9	22.0	PCNA, SELL, VIP, LPL, MYC, BMP6
9	methotrexate32 34 42 9 9	23.6	PIK3C2A, PCNA, SELE, SERPINE1, SERPINA3, NAGLU
10	herbimycin a32 42	19.6	PIK3CG, VTN, SELE, SELL, VCAM1, VAV1
11	ribonucleic acid32	18.2	RBP4, SERPINB2, MYC, BMP6, LIF, BLZF1
12	matrigel32	18.0	PIGF, PIK3CG, VWF, VTN, SELE, SERPINB2
13	methionine32	17.5	RECK, CNTF, VWF, SERPINH1, SERPINB2, SERPINA3
14	agarose32	17.4	CNBP, VWF, SFTPD, LPA, MYC, LIF
15	folate32	17.3	LRP2, RECK, VWF, RBP4, SELE, SERPINC1
16	estradiol32 9 18 9	20.1	PCNA, SERPINE1, SERPINA3, BOK, LIF, PAPPA
17	nacl32	17.0	SERPINA3, LIF, BLZF1, BDNF, CHKB, CHUK
18	allergens32	16.8	LRP2, PDCD1, SFTPD, BLZF1, LGALS3, CIITA
19	glucose32	16.5	CNTF, NAGA, LMAN1, RARRES2, CLEC12A, CISH
20	calcitriol32 42 9 18 9	20.2	LRP2, VDR, MYC, BMP6, LIF, CLU
21	etanercept32 9 9	18.2	LEP, MMP1, MMP3, FCGR1A, FCGR2A, FCGR2B
22	dopamine32 9 18 9	18.9	CNTF, RBP4, SELE, SERPINA3, VIP, NAGLU
23	retinoid32	15.6	RBP4, SELL, VDR, MYC, BMP6, RARRES2
24	n acetylcysteine32	15.5	VWF, PCNA, SELE, SELP, SERPINC1, NAGLU
25	chloroquine32 34 9 9	18.2	VTN, SERPINC1, BMP6, RAF1, CIITA, LDLR
26	tarc32	15.1	CD4, ITGA4, IL10, IL13, IL18, IL1A
27	sulfasalazine32 9 9	16.2	SELE, NAT2, CHUK, MTHFR, MPO, CD79A
28	urea32 9 18 9	17.1	PIK3C2A, RETN, VTN, SERPINA3, NAGLU, LPA
29	betacarotene32	13.8	VWF, PCNA, RBP4, SERPINA3, NAT2, LPL
30	natalizumab32 9 9	15.7	ITGA4, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A
31	corticosterone32 18	14.7	VIP, LIF, BGLAP, BDNF, BCL2A1, CGB5
32	warfarin32 34 9 18 9	17.7	PIK3C2A, VWF, SELP, SERPINC1, NAT2, LPA
33	mannitol32 9 9	15.6	SELP, NAGLU, VCAM1, CHKB, S100B, XDH
34	ibuprofen32 9 18 9	16.6	VCAM1, BMP6, BDNF, LEP, CHUK, CGB5
35	citrate32	13.5	PIK3C2A, SELP, NAGLU, VDR, BLZF1, CHGA
36	4-hydroxynonenal32 18	14.4	MYC, PARP1, CHUK, BAX, XDH, MPO
37	mg 13232 42	14.2	PIK3CG, PCNA, VDR, MYC, BLZF1, PARP1
38	mifepristone32 42 9 9	16.1	LIF, BCL2A1, LCK, BAX, LBR, CGA
39	biotin32 9 18 9	16.0	VWF, PCNA, SELL, LPL, LIAS, B2M
40	fluorescein32 9 9	14.9	SERPINC1, VEGFA, BGLAP, MPO, CD40LG, ITGAM
41	lactacystin32	12.6	PIK3CG, SELE, VDR, MYC, RAF1, PARP1
42	nadph32 18	13.3	MYD88, XRCC1, ASS1, GRIN2A, FCGR3B, HSD17B8
43	hirudin32	12.2	SELL, SERPINC1, FGA, GP1BA, F5, F2RL1
44	docetaxel32 34 9 9	14.8	VEGFA, VDR, MYC, RAF1, CLU, PARP1
45	c2ceramide32	11.7	PIK3CG, PARP1, CHUK, BAX, CGB5, JUN
46	nicotine32 34 9 9	14.7	SELL, IVL, FLG, CCR7, PTHLH, PTPN6
47	geldanamycin32 9 9	13.4	PIK3CG, VEGFA, RAF1, PARP1, KDR, LCK
48	agar32	11.1	CD40LG
49	ceramide32	11.0	RAF1, ANXA5, TNF, CREB1, SYK
50	budesonide32 42 9 9	14.0	SFTPD, BGLAP, CD36, IGHE, F2RL1, NR3C1

Cellular components related to lupus erythematosus according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	46.5	PIK3CD, PIK3C2A, PIK3CG, LRP2, PDCD1, PDCD1LG2
2	extracellular region	GO:005576	35.1	PDCD1LG2, RETN, KIR3DP1, VWA7, VWF, VTN
3	cytoplasm	GO:005737	34.2	PIK3C2A, PIK3CG, LRRC18, NCF2, PCNA, SELP
4	extracellular space	GO:005615	31.6	LRP2, CNTF, VTN, SFTPD, RBP4, SELE
5	cytosol	GO:005829	29.4	PIK3CD, PIK3C2A, PIK3CG, SH2B3, NCF2, REL
6	integral to plasma membrane	GO:005887	27.1	NCR3, KIR2DS3, KIR2DS5, KIR2DL1, KIR2DL3, KIR2DL4
7	external side of plasma membrane	GO:009897	22.4	VWF, BTLA, SELL, SELP, VCAM1, LILRB1
8	nucleoplasm	GO:005654	18.7	REL, RDBP, PCNA, RBMX, NBN, VDR
9	cell surface	GO:009986	17.8	VEGFA, LPAR1, LPL, VCAM1, LDLR, AXL
10	nucleosome	GO:000786	17.1	CENPA, H2AFJ, H2AFV, H2AFX, H2AFY, H2AFY2
11	membrane raft	GO:045121	14.5	SELE, LCK, LAT, P2RX7, MS4A2, CD79A
12	endosome membrane	GO:010008	13.7	VPS52, MYD88, LDLR, UBC, LAMP1, CD14
13	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	13.6	CALR, HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1
14	ER to Golgi transport vesicle membrane	GO:012507	13.4	LMAN1, B2M, HLA-A, HLA-B, HLA-C, HLA-DPA1
15	MHC class II protein complex	GO:042613	13.0	HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1
16	platelet alpha granule lumen	GO:031093	12.5	VWF, SERPINE1, SERPING1, VEGFA, CLU, FGA
17	clathrin-coated endocytic vesicle membrane	GO:030669	12.2	LDLR, FCGR1A, APOB, HLA-DPA1, HLA-DPB1, HLA-DQA1
18	nucleus	GO:005634	INF	ZNF311, ZNF423, PIK3C2A, NCL, CNBP, CNTF

Biological processes related to lupus erythematosus according to GeneDecks:

(show top 50)    (show all 67)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	25.6	PIK3CD, PDCD1, CNTF, KIR2DL4, LPXN, VDR
2	inflammatory response	GO:006954	22.9	PIK3CD, PIK3CG, NCR3, SELE, SELP, SERPINA3
3	cytokine-mediated signaling pathway	GO:019221	20.1	VCAM1, MYD88, CIITA, MX1, UBC, B2M
4	positive regulation of transcription from RNA polymerase II promoter	GO:045944	19.8	CNBP, RBMX, SERPINE1, VEGFA, VDR, MYC
5	apoptotic process	GO:006915	19.7	PDCD1, NBN, BOK, LMNB1, VAV1, RAF1
6	blood coagulation	GO:007596	19.3	PIK3CG, SH2B3, KIFC1, VWF, SELL, SELP
7	nucleosome assembly	GO:006334	17.7	BRD2, CENPA, H2AFB1, H2AFB2, H2AFJ, H2AFV
8	cell-cell signaling	GO:007267	17.1	S100A9, CGA, CGB, CD70, CD86, CD80
9	virus-host interaction	GO:019048	16.9	VCAM1, KDR, LDLR, LCK, BAX, CFLAR
10	cell surface receptor signaling pathway	GO:007166	16.6	MYD88, P2RX7, MPL, CD28, CD2, CD27
11	response to virus	GO:009615	16.5	MYD88, LILRB1, CLU, CHUK, MX1, FOXP3
12	regulation of immune response	GO:050776	16.2	KIR2DL1, KIR2DL3, KIR2DL4, KIR3DL1, KIR2DS2, KIR2DS1
13	interferon-gamma-mediated signaling pathway	GO:060333	16.0	VCAM1, CIITA, B2M, CD44, IRF1, IRF3
14	positive regulation of cell proliferation	GO:008284	16.0	CNBP, CNTF, NBN, VIP, VEGFA, MYC
15	T cell costimulation	GO:031295	15.9	PDCD1, PDCD1LG2, BTLA, VAV1, LCK, FYN
16	platelet activation	GO:030168	15.8	PIK3CG, VWF, SELP, SERPINE1, SERPING1, VEGFA
17	anti-apoptosis	GO:006916	15.7	SERPINB2, MYD88, BDNF, BCL2, BCL2A1, UBC
18	complement activation, classical pathway	GO:006958	15.3	SERPING1, CLU, CFI, CD55, CD46, MBL2
19	response to lipopolysaccharide	GO:032496	15.2	NCF2, SELE, SELP, LIAS, S100A8, S100A9
20	response to drug	GO:042493	15.2	LRP2, NCF2, NBN, LPL, MYC, BGLAP
21	induction of apoptosis	GO:006917	14.9	BOK, MX1, LCK, BAX, CEBPB, CD2
22	response to hypoxia	GO:001666	14.8	VEGFA, VCAM1, RAF1, BCL2, LEP, XRCC1
23	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	14.6	REL, LPAR1, MYD88, LGALS9, CHUK, UBD
24	leukocyte migration	GO:050900	14.6	SELL, SELP, LCK, MSN, FYN, CD2
25	type I interferon-mediated signaling pathway	GO:060337	14.5	MX1, ISG15, ISG20, IRF1, IRF3, IRF4
26	positive regulation of inflammatory response	GO:050729	14.4	SERPINE1, IL12B, IL15, IL18, IL1RL1, IL2
27	positive regulation of NF-kappaB transcription factor activity	GO:051092	14.4	MYD88, CLU, CHUK, UBC, CD40, IRAK1
28	T cell receptor signaling pathway	GO:050852	14.3	PIK3CD, CHUK, ZAP70, UBC, LCK, LCP2
29	complement activation	GO:006956	14.3	CLU, CFB, CFH, CFHR1, CFP, MBL2
30	positive regulation of apoptotic process	GO:043065	14.3	LPAR1, LILRB1, CLU, UBD, BAX, P2RX7
31	defense response to bacterium	GO:042742	14.3	CFP, IRF8, MICA, IL10, MAVS, IFNB1
32	negative regulation of apoptotic process	GO:043066	14.1	PIK3CG, SERPINE1, VEGFA, MYC, RAF1, CLU
33	cellular response to lipopolysaccharide	GO:071222	13.7	SERPINE1, LILRB1, AXL, CD36, CD14, ASS1
34	positive regulation of T cell proliferation	GO:042102	13.7	PDCD1LG2, VCAM1, CD28, ITGAL, IL12A, IL12B
35	positive regulation of interferon-gamma production	GO:032729	13.5	CD40LG, IRF8, IL12A, IL12B, IL12RB1, IL18
36	aging	GO:007568	13.5	LRP2, NCF2, VDR, VCAM1, JUN, ASS1
37	positive regulation of interleukin-12 production	GO:032735	13.3	CD36, CD40LG, CD40, IRF8, IL12B, IL23A
38	platelet degranulation	GO:002576	13.2	VWF, SELP, SERPINE1, SERPING1, VEGFA, CLU
39	positive regulation of tumor necrosis factor production	GO:032760	13.1	MYD88, CD36, CD14, IL12B, IL18, IL23A
40	response to ethanol	GO:045471	13.0	RBP4, BGLAP, BCL2, S100A8, S100A9, FYN
41	humoral immune response	GO:006959	13.0	PDCD1, PAX5, BCL2, MS4A2, CD28, CD83
42	negative regulation of interferon-gamma production	GO:032689	12.7	LILRB1, SCGB1A1, AXL, FOXP3, IL10, IL1RL1
43	leukocyte cell-cell adhesion	GO:007159	12.7	SELE, SELP, VCAM1, MSN, CD40LG, ITGA4
44	positive regulation of interleukin-8 production	GO:032757	12.5	SERPINE1, IL18, IL1B, FADD, MAVS, CALCA
45	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	12.4	VTN, VEGFA, LIF, CD36, CD4, CD80
46	cytolysis	GO:019835	12.3	P2RX7, GZMA, GZMB, MICB, MICA, HPRT1
47	positive regulation of nitric oxide biosynthetic process	GO:045429	12.1	INS, INSR, IL1B, IFNG, ICAM1, HSP90AA1
48	defense response to virus	GO:051607	INF	LILRB1, BCL2, , CD86, CD40, ITGAX
49	innate immune response	GO:045087	INF	PIK3CD, PIK3CG, NCF2, SFTPD, SERPING1, MYD88
50	immune response	GO:006955	INF	NCR3, PDCD1LG2, KIR2DS5, KIR2DL1, KIR2DL3, KIR3DS1

Molecular functions related to lupus erythematosus according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	54.8	ZNF423, PIK3CD, PIK3CG, LRP2, COG2, NCF2
2	DNA binding	GO:003677	25.4	ZNF311, ZNF423, REL, CNBP, SERPINA3, VDR
3	cytokine activity	GO:005125	17.5	CNTF, VEGFA, BMP6, LIF, CD70, CD40LG
4	protein homodimerization activity	GO:042803	16.8	VWF, NAGA, VEGFA, RAG1, LILRB1, BCL2
5	receptor binding	GO:005102	16.4	SERPINE1, LPL, RARRES2, LIF, P2RX7, MSN
6	receptor activity	GO:004872	16.2	KIR2DL1, KIR2DL3, BTLA, LILRA2, CD2, CD86
7	transmembrane signaling receptor activity	GO:004888	14.8	KIR2DL4, KIR2DS2, KIR2DS1, SELE, MPL, CD79A
8	enzyme binding	GO:019899	13.5	BLZF1, BCHE, YWHAB, UBE2L3, LAMB1, MSH2
9	heparin binding	GO:008201	13.4	VTN, SELL, SELP, SERPINC1, SERPIND1, VEGFA
10	growth factor activity	GO:008083	13.2	CNTF, VEGFA, BMP6, LIF, BDNF, LEP
11	chemokine activity	GO:008009	12.9	IL8, CCL8, CCL4, CCL27, CCL2, CCL17
12	tumor necrosis factor receptor binding	GO:005164	12.7	CD70, CD40LG, FASLG, FADD, TRAF2, TNF
13	integrin binding	GO:005178	12.6	VWF, VTN, VCAM1, KDR, LAMB1, CD226
14	protease binding	GO:002020	12.4	SELL, SERPINC1, SERPINE1, BCL2, UBC, CD28
15	MHC class II receptor activity	GO:032395	11.9	HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1