MCID: LPS007
MIFTS: 43

Lupus Nephritis malady

Summaries for Lupus Nephritis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Lupus nephritis is a kidney disorder that is a complication of systemic lupus erythematous (sle), commonly known as lupus. the symptoms of lupus nephritis include blood in the urine, a foamy appearance to the urine, high blood pressure, and swelling in any part of the body. this condition typically occurs in people aged 20 to 40 years. treatment may involve medications to suppress the immune system, dialysis, or a kidney transplant. visit our web page on lupus for more information and resources. last updated: 11/24/2010

MalaCards: Lupus Nephritis is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Lupus Nephritis is FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)), and among its related pathways are Signaling by GPCR and Akt Signaling. The drug cyclophosphamide and the compounds calcium and lipid have been mentioned in the context of this disorder. Affiliated tissues include kidney and skin, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:63 Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE), a disease... more...

Aliases & Classifications for Lupus Nephritis

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42NIH Rare Diseases, 46OMIM, 44Novoseek, 60UMLS
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Aliases & Descriptions:

lupus nephritis 42 46 44 60


Related Diseases for Lupus Nephritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lupus Nephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 213)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus31.3TLR9, APOH, DNASE1, IL18, THBD
2systemic lupus erythematosus31.2FCGR2A
3proteinuria30.9CCL5, CCL2, APOH, RBP4, CD274, NAGLU
4glomerulonephritis30.8VCAM1, FCGR2A, NAGLU, RBP4, CTSG, TLR9
5vasculitis30.6CCL2, APOH, CTSG, THBD, VCAM1
6arthritis30.5CCL5, CCL2, CSF1, CTSG, CXCR3, FCGR3A
7connective tissue disease30.5CCL2, TLR9, APOH, DNASE1, CD40, THBD
8hypertension30.4VCAM1, CCL2
9nephrotic syndrome30.4RBP4, NAGLU
10antiphospholipid syndrome30.4VCAM1, THBD, APOH
11rheumatoid arthritis30.2CCR4, CCL5, CCL2, TLR9, CSF1, APOH
12thrombocytopenia30.2CSF1, APOH, FCGR2A, FCGR3A, THBD
13atherosclerosis30.0CCL5, CCL2, TLR9, VCAM1, THBD, FCGR2A
14tuberculosis30.0CCR4, TLR9, CTSG, DNASE1, CXCR3, IL18
15leukemia30.0CSF1, CTSG, RBP4, DNASE1, CD40, CXCR3
16diabetes mellitus30.0CCL2, RBP4, NAGLU, THBD, VCAM1
17pre-eclampsia30.0VCAM1, THBD, IL18, NAGLU, APOH
18hepatitis c30.0IL18, CXCR3, RBP4
19peritonitis30.0CTSG, CCL2
20hepatitis30.0IL18
21eclampsia30.0THBD
22vascular disease30.0CCL2, APOH, THBD, VCAM1
23sickle cell disease30.0VCAM1
24kidney disease10.5
25interstitial nephritis10.4
26membranous glomerulonephritis10.3
27membranoproliferative glomerulonephritis10.3
28purpura10.2
29graft versus host disease10.2
30crescentic glomerulonephritis10.2
31focal segmental glomerulosclerosis10.2
32central nervous system lymphoma10.2
33proliferative glomerulonephritis10.2
34thrombotic thrombocytopenic purpura10.2
35takayasu's arteritis10.2
36renal tubular acidosis10.2
37focal glomerulosclerosis10.2
38hypothyroidism10.2
39intracranial hypertension10.2
40malignant hypertension10.2
41hellp syndrome10.0
42crohn's disease10.0
43cardiac tamponade10.0
44non-hodgkin lymphoma10.0
45periarthritis10.0
46myelitis10.0
47lemierre's syndrome10.0
48coccidioidomycosis10.0
49cerebritis10.0
50juvenile myelomonocytic leukemia10.0

Graphical network of the top 20 diseases related to Lupus Nephritis:



Diseases related to lupus nephritis

Clinical Features for Lupus Nephritis

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Drugs & Therapeutics for Lupus Nephritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lupus Nephritis

Drug clinical trials:

Search ClinicalTrials for Lupus Nephritis

Search NIH Clinical Center for Lupus Nephritis

Search CenterWatch for Lupus Nephritis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Lupus Nephritis

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Anatomical Context for Lupus Nephritis

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32MalaCards
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MalaCards organs/tissues related to Lupus Nephritis:

32
Kidney, Skin

Animal Models for Lupus Nephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lupus Nephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.6CCR4, C3AR1, VCAM1, THBD, FCGR3A, FCGR2A
2MP:000539711.5VCAM1, CD40, FCGR2A, IL18, NAGLU, THBD
3MP:000538411.4CCL5, CCL2, TLR9, CSF1, GATA3, THBD
4MP:000537611.3RBP4, APOH, CSF1, TLR9, CCL2, DNASE1
5MP:001076811.3C3AR1, VCAM1, THBD, FCGR2A, IL18, CXCR3
6MP:000538510.8VCAM1, THBD, IL18, CXCR3, NAGLU, RBP4
7MP:000537010.8NAGLU, CTSG, CSF1, CCL2, C3AR1, THBD
8MP:000539010.7GATA3, C3AR1, NAGLU, CD40, CSF1
9MP:000536710.3NAGLU, DNASE1

Publications for Lupus Nephritis

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Genetic Variations for Lupus Nephritis

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Expression for genes affiliated with Lupus Nephritis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lupus Nephritis

Search GEO for disease gene expression data for Lupus Nephritis.

Pathways for genes affiliated with Lupus Nephritis

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Sources:
53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems
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Pathways related to Lupus Nephritis according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9CCL2, CXCR3, VCAM1, RBP4, TLR9, CCL5
2
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10.8CSF1, CXCR3, CCL2, CCL5, CCR4, TLR9
3
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10.8CXCR3, CTSG, CCL2, CCL5, CCR4, C3AR1
4
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10.8CCL2, CCL5, IL18, CXCR3, CCR4, CSF1
5
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10.7IL18, FCGR2A, FCGR3A, CD40, GATA3
6
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10.7CCL5, VCAM1, CXCR3, CCR4, CCL2
710.7FCGR2A, IL18, TLR9, FCGR3A
8
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10.7FCGR2A, FCGR3A, CD40, CTSG
9
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10.7VCAM1, FCGR2A, CD40, FCGR3A
10
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10.7TLR9, CCL5, CCL2, CD40
11
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10.7CCR4, CCL5, CCL2, CXCR3
1210.7CCL5, CCR4, CXCR3, CCL2
1310.7VCAM1, CSF1, CCL2, CCL5
14
Hide members
10.7CCR4, CSF1, CD40, CXCR3
1510.6C3AR1, FCGR2A, FCGR3A
1610.6C3AR1, CD40, CCL2
1710.6TLR9, CD40, IL18
1810.6VCAM1, IL18, TLR9
19
Hide members
10.6CCL5, CCL2, IL18
2010.6IL18, CSF1, CCL2
21
Hide members
10.6GATA3, IL18, TLR9
2210.6VCAM1, CSF1, CCL2
2310.5IL18

Compounds for genes affiliated with Lupus Nephritis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Lupus Nephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.7CCR4, C3AR1, FCGR3A, FCGR2A, IL18, CCL5
2lipid4411.5CCL5, CCL2, RBP4, CD40, NAGLU, IL18
3creatinine4411.5CXCR3, CCL5, CCL2, CSF1, APOH, CTSG
4cholesterol44 28 11 2414.5RBP4, CCL2, CCL5, FCGR3A, APOH, THBD
5nitric oxide44 11 2413.5CTSG, CXCR3, CD274, CD40, NAGLU, THBD
6tyrosine4411.5TLR9, CSF1, GATA3, CD40, CXCR3, IL18
7histamine44 28 2413.5C3AR1, CCL5, CCL2, CD40, VCAM1, THBD
8retinoic acid44 2412.4VCAM1, THBD, IL18, CD40, CCR4, CCL5
9lactate4411.4VCAM1, CCL5, RBP4, THBD, CTSG, APOH
10serine4411.4CCL5, RBP4, CCL2, CSF1, CXCR3, IL18
11arginine4411.4CXCR3, CTSG, APOH, CSF1, CCL2, FCGR3A
12simvastatin44 49 59 28 11 2416.3CCR4, CCL5, CCL2, RBP4, CD40, IL18
13heparin44 28 11 2414.3CCL5, CSF1, APOH, CTSG, NAGLU, CXCR3
14fmlp4411.3VCAM1, FCGR2A, C3AR1, CXCR3, CTSG, CSF1
15n acetylcysteine4411.3CD40, DNASE1, CCL5, CCL2, NAGLU, IL18
16ly2940024411.2IL18, CD40, FCGR2A, VCAM1, CSF1, CCL2
17homocysteine44 2412.2CCL2, APOH, NAGLU, VCAM1, CCL5, THBD
18prednisolone44 28 1113.2THBD, CCR4, CD40, FCGR2A, CSF1, APOH
19paraffin4411.2CCL2, CSF1, CTSG, DNASE1, CD40, THBD
20etanercept44 49 1113.2FCGR3A, FCGR2A, IL18, APOH, CSF1, CXCR3
21prostacyclin4411.2CSF1, APOH, CTSG, FCGR2A, THBD, CCL2
22ionomycin4411.2CCL5, CSF1, IL18, CD40, CD274, GATA3
23vegf4411.2CXCR3, IL18, THBD, CSF1, VCAM1, CD40
24il 104411.2CCL5, IL18, CXCR3, CD40, CSF1, CCL2
25h2o24411.2THBD, CTSG, DNASE1, CD40, NAGLU, IL18
26endotoxin4411.2APOH, CTSG, CXCR3, THBD, VCAM1
27ccl344 2812.2CCR4, CCL5, CCL2, TLR9, CXCR3, IL18
28aspartate4411.2VCAM1, NAGLU, DNASE1, RBP4, CTSG, CCL2
29zinc44 2412.1APOH, CD40, DNASE1, RBP4, NAGLU, GATA3
30dexamethasone44 49 28 1114.1RBP4, GATA3, CCL5, DNASE1
31polysaccharide4411.1DNASE1, CCL2, THBD, CTSG, VCAM1, IL18
32cyclophosphamide44 49 1113.1THBD, NAGLU, CD40, APOH
33groalpha4411.1CCL2, CXCR3, CCL5, IL18, VCAM1
34glucose4411.1THBD, APOH, RBP4, CCL5, CD40, NAGLU
35rantes4411.1CSF1, CD40, CXCR3
36polyinosinic-polycytidylic acid4411.1VCAM1, IL18, TLR9, CD40, CSF1
37oxygen44 2412.0CD40, CCL2, RBP4, NAGLU, FCGR3A
38alanine4411.0DNASE1, THBD, CSF1, CCL5, IL18, CTSG
39fibrinogen4411.0CTSG, APOH, CCL2, THBD, VCAM1, IL18
40superoxide44 2412.0VCAM1, APOH, CXCR3, CD40, CCL2
41tarc4411.0CCL2, CCL5, CCR4, IL18, CXCR3
42ivig4411.0APOH, FCGR3A, FCGR2A, CD40, CSF1
43fluvastatin44 49 28 1113.9CD40, IL18, THBD, CCL2, VCAM1
44estrogen4410.8APOH
45wortmannin4410.8CCL5, CCL2, VCAM1, CD40, CXCR3, FCGR2A
46pd 98,0594410.8CSF1, VCAM1, IL18, CD40, CCL5, CCL2
47larc4410.8CCL5, CCR4, CXCR3, CCL2
48neopterin4410.8IL18, THBD, CD40, CSF1, NAGLU
49rituximab44 49 1112.6APOH, CSF1, CD40, FCGR2A, FCGR3A
50folate4410.5CCL5, VCAM1, IL18, APOH, RBP4, THBD

GO Terms for genes affiliated with Lupus Nephritis

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16Gene Ontology
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Cellular components related to Lupus Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.1CCR4, TLR9, CSF1, CTSG, CD274, CD40
2extracellular spaceGO:00561510.8APOH, CTSG, RBP4, IL18, VCAM1, CCL2
3external side of plasma membraneGO:00989710.8CCR4, VCAM1, FCGR3A, CXCR3, CD40, CD274
4extracellular regionGO:00557610.6FCGR3A, CCL5, CTSG, RBP4, DNASE1, CD40

Biological processes related to Lupus Nephritis according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.3TLR9, CSF1, CD40, CXCR3, IL18, C3AR1
2chemotaxisGO:00693511.1CXCR3, CCR4, CCL5, C3AR1, CCL2
3cellular response to tumor necrosis factorGO:07135611.0IL18, GATA3, CCL2, CCL5
4immune responseGO:00695511.0FCGR3A, IL18, CD274, CTSG, CCR4
5positive regulation of macrophage chemotaxisGO:01075911.0C3AR1, CCL2, CCL5
6cellular response to interferon-gammaGO:07134610.9CCL2, IL18, CCL5
7chemokine-mediated signaling pathwayGO:07009810.9CCL2, CCL5, CCR4
8lipopolysaccharide-mediated signaling pathwayGO:03166310.9CCL5, CCL2, IL18
9cellular response to organic cyclic compoundGO:07140710.9IL18, CCL2, CCL5
10positive regulation of T cell proliferationGO:04210210.9CCL5, CD274, VCAM1
11MAPK cascadeGO:00016510.9CCL5, CCL2, IL18
12maintenance of gastrointestinal epitheliumGO:03027710.8TLR9, RBP4
13cellular calcium ion homeostasisGO:00687410.8CCL5, CCL2, CD40
14uterus developmentGO:06006510.8GATA3, RBP4
15response to ethanolGO:04547110.8GATA3, RBP4, CCL2
16negative regulation of fibrinolysisGO:05191810.7APOH, THBD
17positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.6CCL2, TLR9
18elevation of cytosolic calcium ion concentrationGO:00720410.6CCR4, C3AR1, CXCR3
19regulation of immune responseGO:05077610.6CD40, FCGR3A, VCAM1
20negative regulation of blood coagulationGO:03019510.5APOH, THBD
21macrophage chemotaxisGO:04824610.3CCL5, CCL2

Molecular functions related to Lupus Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.6FCGR3A, FCGR2A

Products for genes affiliated with Lupus Nephritis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Lupus Nephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet