MCID: LPS007
MIFTS: 52

Lupus Nephritis malady

Rare diseases category
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Summaries for Lupus Nephritis

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Lupus nephritis is a kidney disorder that is a complication of systemic lupus erythematous (sle), commonly known as lupus. the symptoms of lupus nephritis include blood in the urine, a foamy appearance to the urine, high blood pressure, and swelling in any part of the body. this condition typically occurs in people aged 20 to 40 years. treatment may involve medications to suppress the immune system, dialysis, or a kidney transplant. visit our web page on lupus for more information and resources. last updated: 11/24/2010

MalaCards: Lupus Nephritis is related to nephritis and systemic lupus erythematosus. An important gene associated with Lupus Nephritis is FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)), and among its related pathways are African trypanosomiasis and A-beta Uptake and Degradation. The drug cyclophosphamide and the compounds dotap and natalizumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and monocytes, and related mouse phenotypes are cellular and renal/urinary system.

Wikipedia:65 Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE), a disease... more...

Aliases & Classifications for Lupus Nephritis

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43NIH Rare Diseases, 47OMIM, 45Novoseek, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

lupus nephritis 43 47 45 62


Related Diseases for Lupus Nephritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lupus Nephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1nephritis32.1CCL2, CXCR3, FCGR3A, FCGR2A, CFB, IL18
2systemic lupus erythematosus31.4PDCD1, FCGR2A
3lupus erythematosus31.4APOH, DNASE1, TLR9, IL18
4proteinuria31.1CCL2, CD274, APOH
5glomerulonephritis30.8TLR9, CTSG, CCL2, FCGR2A
6vasculitis30.7APOH, CCL2, CTSG
7connective tissue disease30.5TLR9, APOH, CCL2, CD40, DNASE1
8proliferative glomerulonephritis30.4CXCR3, CCL2
9arthritis30.4CTSG, IL18, CCL2, CXCR3, FCGR3A, FCGR2A
10thrombocytopenia30.4APOH, FCGR2A, FCGR3A
11rheumatic disease30.1CXCR3, APOH, FCGR2A, IL18
12non-hodgkin lymphoma30.1CD40, FCGR2A, FCGR3A
13tuberculosis30.0IL18, CXCR3, TLR9, CTSG, DNASE1
14atherosclerosis29.9APOH, CD40, CXCR3, FCGR2A, IL18, CCL2
15rheumatoid arthritis29.7CTSG, FCGR2A, FCGR3A, CXCR3, CCL2, IL18
16kidney disease10.5
17endotheliitis10.5
18membranoproliferative glomerulonephritis10.3
19hypertension10.3
20nephrotic syndrome10.3
21purpura10.3
22bullous systemic lupus erythematosus10.3
23graft versus host disease10.2
24antiphospholipid syndrome10.2
25focal segmental glomerulosclerosis10.2
26renal fibrosis10.2
27thrombotic thrombocytopenic purpura10.2
28takayasu's arteritis10.2
29central nervous system lymphoma10.2
30renal tubular acidosis10.2
31crescentic glomerulonephritis10.2
32glomerulosclerosis10.2
33hypothyroidism10.2
34intracranial hypertension10.2
35malignant hypertension10.2
36chronic graft versus host disease10.2
37virus associated hemophagocytic syndrome10.2
38diffuse alveolar hemorrhage10.2
39periodontitis10.1FCGR2A
40primary immunodeficiency disease10.1CD40
41malaria10.1FCGR2A, TLR9
42pleural tuberculosis10.1CCL2, IL18
43relapsing-remitting multiple sclerosis10.1CXCR3, IL18
44periapical granuloma10.1CXCR3, CCL2
45plasmodium falciparum malaria10.1FCGR2A, IL18
46hepatitis b10.1CFB, DNASE1
47pulmonary sarcoidosis10.1CCL2, IL18, CXCR3
48idiopathic pulmonary fibrosis10.0CXCR3, CCL2, IL18
49hairy cell leukemia10.0CXCR3, CD40
50atopy10.0TLR9, IL18, CXCR3

Graphical network of the top 20 diseases related to Lupus Nephritis:



Diseases related to lupus nephritis

Symptoms for Lupus Nephritis

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Drugs & Therapeutics for Lupus Nephritis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Lupus Nephritis

Search NIH Clinical Center for Lupus Nephritis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Lupus Nephritis

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Anatomical Context for Lupus Nephritis

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33MalaCards
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MalaCards organs/tissues related to Lupus Nephritis:

33
Kidney, Skin, Monocytes, T cells, B cells, Endothelial, Testes, Liver, Heart, Whole blood

Animal Models for Lupus Nephritis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Lupus Nephritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.6CXCR3, CCL2, IL18, DNASE1, PDCD1, CD274
2MP:00053677.4TLR9, CFB, CXCR3, DNASE1, PDCD1, CD40
3MP:00053906.8CFB, FCGR2A, FCGR3A, CCL2, C3AR1, PDCD1
4MP:00053766.5TLR9, CFB, APOH, FCGR3A, CXCR3, CCL2
5MP:00107686.2CXCR3, FCGR2A, APOH, TLR9, CCL2, IL18
6MP:00053975.7CCL2, CXCR3, FCGR3A, FCGR2A, TLR9, IL18
7MP:00053875.2CTSG, TLR9, CFB, FCGR2A, FCGR3A, CXCR3

Publications for Lupus Nephritis

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Sources:
52PubMed
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Articles related to Lupus Nephritis:

(show top 50)    (show all 764)
idTitleAuthorsYear
1
Prednisone in lupus nephritis: how much is enough? (24189280)
2014
2
Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis with poor kidney function: a subgroup analysis of the Aspreva Lupus Management Study. (23375819)
2013
3
Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. (23896866)
2013
4
Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis. (23301082)
2013
5
Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming. (24300027)
2013
6
Low risk of renal flares and negative outcomes in women with lupus nephritis conceiving after switching from mycophenolate mofetil to azathioprine. (23382355)
2013
7
Kidney disease in lupus is not always 'lupus nephritis' (23448342)
2013
8
Current management of lupus nephritis. (24238689)
2013
9
Antiphospholipid syndrome nephropathy (APSN) in patients with lupus nephritis: a retrospective clinical and renal pathology study. (24232504)
2013
10
Predictive risk factors for failure to induction therapy of lupus nephritis in a cohort of Colombian patients. (24269070)
2013
11
Survival analysis and causes of mortality in patients with lupus nephritis. (22523116)
2012
12
The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis. (22900150)
2012
13
Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis. (22128082)
2012
14
Long-term outcome of lupus nephritis in Asian Indians. (22232126)
2012
15
Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis. (22348591)
2012
16
From the Large Scale Expression Analysis of Lupus Nephritis to Targeted Molecular Medicine. (23626922)
2012
17
Anti-C1q autoantibodies specific against the globular domain of the C1qB-chain from patient with lupus nephritis inhibit C1q binding to IgG and CRP. (22209113)
2012
18
Efficacy of rituximab in 164 patients with biopsy-proven lupus nephritis: pooled data from European cohorts. (22032879)
2012
19
A meta-analysis of randomized controlled trials comparing tacrolimus with intravenous cyclophosphamide in the induction treatment for lupus nephritis. (22820853)
2012
20
Major infections including tuberculosis as a primary risk factor for poor outcome of lupus nephritis in Asian Indians: comment on the article by Dhir et al. (22833501)
2012
21
Altered expression of TNFSF4 and TRAF2 mRNAs in peripheral blood mononuclear cells in patients with systemic lupus erythematosus: association with atherosclerotic symptoms and lupus nephritis. (22847298)
2012
22
Tumor necrosis factor-like weak inducer of apoptosis and its potential roles in lupus nephritis. (22297307)
2012
23
Recent advances in the treatment of lupus nephritis. (22057583)
2012
24
Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus. (21163672)
2011
25
The role of cytokines as biomarkers in systemic lupus erythematosus and lupus nephritis. (21372259)
2011
26
Predictive value of remission status after 6A months induction therapy in patients with proliferative lupus nephritis: a retrospective analysis. (21594768)
2011
27
Connective tissue diseases: Lupus nephritis-winning a few battles but not the war. (21691329)
2011
28
Complement factor H deficiency accelerates development of lupus nephritis. (21148254)
2011
29
The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans. (20523037)
2010
30
Intracranial hypertension: A rare presentation of lupus nephritis. (21559160)
2010
31
Increased urinary levels of the leukocyte adhesion molecules ICAM-1 and VCAM-1 in human lupus nephritis with advanced renal histological changes: preliminary findings. (20714774)
2010
32
Expression and significance of CD80/CD86 in renal tissue of lupus nephritis]. (20979791)
2010
33
Estimation of monocyte-chemoattractantprotein-1 (Mcp-1) level in patients with lupus nephritis. (20374368)
2009
34
An acquired inhibitor to the GPVI platelet collagen receptor in a patient with lupus nephritis. (19583823)
2009
35
Biomarkers of lupus nephritis determined by serial urine proteomics. (18596723)
2008
36
Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis. (17530720)
2007
37
Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis. (17239933)
2007
38
Ethnic, clinical and immunological factors in systemic lupus erythematosus and the development of lupus nephritis: results from a multi-ethnic New Zealand cohort. (17895308)
2007
39
Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis. (16461436)
2006
40
C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist. (16052609)
2005
41
The interplay of chemokines and dendritic cells in the pathogenesis of lupus nephritis. (16126984)
2005
42
Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis. (16335585)
2005
43
Mesangial cell Fas ligand: upregulation in human lupus nephritis and NF-kappaB-mediated expression in cultured human mesangial cells. (15480896)
2004
44
Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis. (15119544)
2004
45
Antiphospholipid antibodies in patients with lupus nephritis. (14575283)
2003
46
Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. (12115187)
2002
47
Association of anticardiolipin antibodies with intraglomerular thrombi and renal dysfunction in lupus nephritis. (9709458)
1998
48
Highly cationic anti-DNA antibodies in patients with lupus nephritis analyzed by two-dimensional electrophoresis and immunoblotting. (9694304)
1998
49
Expression of intercellular adhesion molecule-1 and vascular adhesion molecule-1 in kidney of patients with lupus nephritis and membranoproliferative glomerulonephritis]. (7544695)
1995
50
Anti-cardiolipin antibody and renal microthrombi in lupus nephritis]. (1767341)
1991

Variations for Lupus Nephritis

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Expression for genes affiliated with Lupus Nephritis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lupus Nephritis

Search GEO for disease gene expression data for Lupus Nephritis.

Pathways for genes affiliated with Lupus Nephritis

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Sources:
50PathCards, 30KEGG, 54R&D Systems, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN
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Pathways related to Lupus Nephritis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL18, TLR9
29.4CD40, C3AR1, CCL2
3
Show member pathways
9.3CFB, FCGR2A, FCGR3A
4
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.2CD40, CCL2, TLR9
5
Show member pathways
9.2CD274, PDCD1
6
Show member pathways
9.1IL18, CCL2, CXCR3, TLR9
79.1IL18, FCGR3A, FCGR2A, TLR9
89.0CFB, FCGR2A, FCGR3A, C3AR1
9
Show member pathways
9.0CXCR3, CCL2, IL18, CD40
10
Show member pathways
9.0FCGR2A, FCGR3A, IL18, CD40
11
Show member pathways
9.0CXCR3, CCL2, C3AR1, CTSG
128.9CD40, IL18, CCL2, TLR9
13
Show member pathways
8.7FCGR2A, FCGR3A, CD40, CTSG
148.7CD40, CD274, PDCD1
15
Show member pathways
8.3FCGR3A, PDCD1, CD274, CD40

Compounds for genes affiliated with Lupus Nephritis

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 24HMDB
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Compounds related to Lupus Nephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1dotap4510.2TLR9, DNASE1
2natalizumab45 1110.9IL18, FCGR3A, FCGR2A
3groalpha459.8IL18, CCL2, CXCR3
4flagellin45 2910.8IL18, CXCR3, TLR9
5cetuximab45 51 1111.8TLR9, FCGR2A, FCGR3A
6infliximab45 51 1111.7APOH, FCGR2A, CXCR3, IL18
7tarc459.7IL18, CCL2, CXCR3
8abciximab45 1110.7FCGR2A, FCGR3A, CD40
9lipoteichoic acid459.6IL18, CCL2, APOH, TLR9
10ccl345 2910.5TLR9, IL18, CXCR3, CCL2
11lfa70345 1110.5IL18, CD40
12polyinosinic-polycytidylic acid459.5IL18, CD40, TLR9
13prednisolone45 29 1111.5CD40, APOH, FCGR2A, IL18
14mevalonate459.4CCL2, IL18, CD40
15ivig459.4FCGR2A, FCGR3A, CD40, APOH
16rituximab45 51 1111.4APOH, CD40, FCGR2A, FCGR3A
17il 10459.4CCL2, IL18, CD40, CXCR3
18etanercept45 51 1111.4IL18, FCGR2A, CXCR3, FCGR3A, APOH
19mannose459.4FCGR2A, FCGR3A, CD40, APOH
20fluvastatin45 51 29 1112.4CCL2, CD40, IL18
21pge1459.3APOH, CD40, IL18
22cyclophosphamide45 51 1111.3CD40, IL18, CCL2, APOH
23prostacyclin459.3CTSG, CCL2, FCGR2A, APOH
24methotrexate51 45 1111.2APOH, IL18, FCGR3A, CD40
25n acetylcysteine459.1IL18, DNASE1, CD40, CCL2
26ly294002459.1CD40, IL18, CCL2, CXCR3, FCGR2A
27polysaccharide459.1CTSG, DNASE1, IL18, CCL2, FCGR2A
28heparin45 29 24 1112.0DNASE1, CTSG, APOH, CXCR3, FCGR2A
29rantes459.0CD40, IL18, CCL2, CXCR3, TLR9
30pdtc459.0CD40, IL18, CCL2
31allergens458.9CXCR3, IL18, PDCD1, CD40
32fibrinogen458.8CTSG, APOH, CCL2, IL18, CD40
33fmlp458.7C3AR1, CXCR3, CCL2, FCGR3A, FCGR2A, CTSG
34thymidine45 249.7CTSG, DNASE1, IL18, CXCR3, CD40
35phosphatidylinositol458.7APOH, CXCR3, FCGR2A, FCGR3A, CCL2, CD40
36superoxide45 249.7APOH, CXCR3, CTSG, CD40, CCL2
37h2o2458.7FCGR2A, IL18, DNASE1, CD40, CTSG
38dexamethasone45 51 29 1111.6CXCR3, IL18, DNASE1, CD274, CCL2, CD40
39cholesterol45 29 24 1111.5CCL2, CD40, CXCR3, FCGR2A, APOH, FCGR3A
40oxygen45 249.5IL18, APOH, FCGR2A, CD40, FCGR3A, CXCR3
41arginine458.4IL18, APOH, FCGR2A, FCGR3A, CXCR3, CCL2
42histamine45 29 2410.3CCL2, IL18, CXCR3, C3AR1, FCGR2A, CD40
43creatinine458.3CD40, IL18, DNASE1, CTSG, APOH, CXCR3
44endotoxin458.2APOH, TLR9, CXCR3, CCL2, IL18, CD40
45lipid458.1CD40, CCL2, IL18, APOH, FCGR2A, CTSG
46glucose458.1CD40, CTSG, IL18, APOH, CFB, CCL2
47nitric oxide45 24 119.7IL18, CD274, CCL2, CD40, CXCR3, APOH
48tyrosine457.6CD40, C3AR1, CXCR3, FCGR2A, TLR9, FCGR3A
49calcium45 51 24 1110.3CTSG, DNASE1, APOH, FCGR2A, FCGR3A, CXCR3
50serine457.1CTSG, CFB, FCGR2A, CXCR3, CCL2, IL18

GO Terms for genes affiliated with Lupus Nephritis

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16Gene Ontology
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Cellular components related to Lupus Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.4CTSG, CD40, IL18, CCL2, APOH
2external side of plasma membraneGO:0098978.0CD40, CD274, PDCD1, CXCR3, FCGR3A
3extracellular regionGO:0055767.3TLR9, CFB, FCGR3A, CCL2, IL18, DNASE1
4plasma membraneGO:0058865.9FCGR3A, FCGR2A, CFB, TLR9, CXCR3, C3AR1

Biological processes related to Lupus Nephritis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage chemotaxisGO:01075910.1CCL2, C3AR1
2positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.0TLR9, CCL2
3negative regulation of endothelial cell proliferationGO:00193710.0APOH, CXCR3
4positive regulation of NF-kappaB import into nucleusGO:0423469.9IL18, TLR9
5negative regulation of angiogenesisGO:0165259.8CCL2, CXCR3, APOH
6lipopolysaccharide-mediated signaling pathwayGO:0316639.8IL18, CCL2
7cellular response to organic cyclic compoundGO:0714079.8IL18, CCL2
8chemotaxisGO:0069359.8C3AR1, CCL2, CXCR3
9positive regulation of interleukin-12 productionGO:0327359.7CD40, TLR9
10cell surface receptor signaling pathwayGO:0071669.6CXCR3, CCL2, CD274
11angiogenesisGO:0015259.4CXCR3, CCL2, IL18
12immune responseGO:0069558.9CTSG, CD274, IL18, FCGR3A
13inflammatory responseGO:0069548.6CD40, TLR9, CXCR3, CCL2, IL18, C3AR1
14innate immune responseGO:0450878.6FCGR3A, FCGR2A, CFB, TLR9

Molecular functions related to Lupus Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:0198649.5FCGR3A, FCGR2A
2heparin bindingGO:0082019.2CTSG, CCL2, APOH

Products for genes affiliated with Lupus Nephritis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Lupus Nephritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet