Lupus Nephritis malady

NIH Rare Diseases: Lupus nephritis is a kidney disorder that is a complication of systemic lupus erythematous (SLE), commonly known as lupus. The symptoms of lupus nephritis include blood in the urine, a foamy appearance to the urine, high blood pressure, and swelling in any part of the body. This condition typically occurs in people aged 20 to 40 years. Treatment may involve medications to suppress the immune system, dialysis, or a kidney transplant. Visit our Web page on lupus for more information and resources.³⁰

MalaCards: Lupus Nephritis is related to systemic lupus erythematosus and glomerulopathy. An important gene associated with Lupus Nephritis is FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)), and among its related pathways are Staphylococcus aureus infection and RAR-Gamma-RXR-Alpha Degradation. The drug cyclophosphamide and the compounds cyclophosphamide and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, kidney and skin, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia: Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE), a disease...⁴⁴ more...

lupus nephritis 30 33 32 43

Diseases related to lupus nephritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 958)

id	Related Disease	Score	Top Affiliating Genes
1	systemic lupus erythematosus	35.4	PDCD1, IRF5, FCGR2B, FASLG, C4A, DNASE1
2	glomerulopathy	29.6	VWF, SELE, NAGLU, BMP6, CD79A, CD40LG
3	rheumatoid arthritis	29.4	IL1RN, HLA-DRB1, CRP, LTA
4	arthritis	29.3	MMP3, IL17A, IL6, TNF, CTSG
5	malignant hypertension	29.3	VWF, APOH, EDN1, ACE, AGT, AGTR1
6	hypertension	29.3	NOS2, NOS3, ACE, AGT, AGTR1
7	systemic lupus erythematosus, association with	28.7	PDCD1, SERPINE1, CD40LG, CD274, IRF5, FCGR2A
8	retinol binding protein	28.6	RBP4, NAGLU, LCN2, B2M, MKI67, CCL2
9	graft versus host disease	28.3	IL10, IL11, IL13, IL18, IL1RAPL2, IL2RA
10	fabry disease	28.1	VWF, SELE, VCAM1, LCN2, IL10, IL6
11	proteinuria	27.6	VWF, RBP4, SERPINE1, NAGLU, VEGFA, VCAM1
12	crohn's disease	26.8	LCN2, CD80, IL10, IL11, IL13, IL17A
13	antiphospholipid syndrome	26.6	VWF, SELE, SERPINE1, VEGFA, VCAM1, CD79A
14	nephritis	26.2	PDCD1, PDCD5, VWF, PCNA, RBP4, SELE
15	vasculitis	25.7	PDCD1, VWF, SELE, VEGFA, VCAM1, BMP6
16	nephrotic syndrome	23.9	VWF, PCNA, RBP4, SELE, SERPINE1, NAGLU
17	glomerulonephritis	23.2	VWF, PCNA, RBP4, SERPINE1, NAGLU, VEGFA
18	purpura	21.8	VWF, SELE, SERPINE1, VEGFA, VCAM1, BMP6
19	lupus erythematosus	21.8	PDCD1, VWF, PCNA, RBP4, SELE, SERPINE1
20	fibrosis	17.5	VWF, PCNA, RBP4, SELE, SERPINE1, NAGLU
21	nephropathy	17.4	PDCD1, VWF, PCNA, RBP4, SELE, SERPINE1
22	membranous glomerulonephritis	14.2	CD79A, CCL2, CCR5, ALB, CR1, NPHS1
23	intermediate uveitis	14.2	IL2RA, CCR4, CCR5, CXCR3
24	immune-complex glomerulonephritis	14.2	VCAM1, CD40LG, CCR5, ICAM1, ALB
25	hypersensitivity reaction type iii disease	14.2	ALB, CR1, C4A, C4B, C5AR1
26	complement deficiency	14.1	APOH, CR1, C4A, C4B, C5, C5AR1
27	selective iga deficiency disease	14.1	CD79A, CD40LG, IL10, LTA
28	primary biliary cirrhosis	14.1	PDCD1, CIITA, CD79A, CD40LG, ALB, HLA-DRB1
29	smallpox	14.1	CD4, IL18, IL18BP, IL18R1, CCR5, CR1
30	immune defect due to absence of thymus	14.1	CD79A, CD40LG, CD40, IL10, IL13, IL18R1
31	primary immunodeficiency disease	14.1	CIITA, CD4, CD40LG, CD40, FCGR3A, FCGR3B
32	lipoid nephrosis	14.1	NAGLU, CD79A, IL13, CCL2, ALB, SPP1
33	heparin-induced thrombocytopenia	14.1	SELE, SERPINE1, CD79A, CD40LG, FCGR2A, FCGR3A
34	hiv-1, resistance to	14.0	CD4, CD40, IL10, CCR2, CCL2, CCR5
35	primary hyperoxaluria	14.0	RBP4, NAGLU, B2M, ALB
36	agammaglobulinemia	14.0	CD79A, CD40LG, CD40, LTA
37	henoch-schoenlein purpura	14.0	VCAM1, MX1, CD79A, ICAM1
38	calciphylaxis	14.0	CD79A, CD40LG, ALB, SPP1
39	extrinsic allergic alveolitis	14.0	B2M, IL2RA, CCL2, CCL3, CCL5, CTSG
40	oral lichen planus	14.0	VCAM1, CCR5, CCL5, ICAM1, CASP3, CXCR3
41	vernal keratoconjunctivitis	14.0	VCAM1, IL13, CCL5, ICAM1, CXCR3
42	steroid-resistant nephrotic syndrome	14.0	NAGLU, B2M, CCL2, ALB, ACE, NPHS1
43	htlv-1 associated myelopathy/tropical spastic paraparesis	14.0	PDCD1, CD274, IL2RA, FASLG, RPS27A
44	severe congenital neutropenia	14.0	ITGB2, FCGR2A, FCGR3A, FCGR3B, IL18R1, HLA-DQB1
45	epidermolysis bullosa acquisita	13.9	CD79A, FCGRT, IL2RA, HLA-DRB1, TGFB1
46	follicular lymphoma	13.9	CD80, CD40, FCGR2B, FCGR3A, TNFSF10, CR1
47	allergic contact dermatitis of eyelid	13.9	SELE, IL17A, CCR4, ICAM1, CXCL10, CXCR3
48	inclusion body myositis	13.9	VCAM1, CD80, ICAM1, RPS27A, COX5A
49	chronic pyelonephritis	13.9	NAGLU, B2M, CD79A, ALB
50	diffuse infiltrative lymphocytosis syndrome	13.9	B2M, FCGR3B, IL2RA, FASLG, CCL5

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cyclophosphamide

MalaCards organs/tissues related to lupus nephritis:

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MGI Mouse Phenotypes related to lupus nephritis:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	FCGR2B, MT1A, MT2A, CMKLR1, CCR2, CCR4
2	endocrine/exocrine gland phenotype	MP:0005379	10.4	PATZ1, CD40LG, FASLG, IFNG, LTA, CXCL16
3	hematopoietic system phenotype	MP:0005397	9.6	PDCD1, PCNA, CMKLR1, PATZ1, LCN2, MT2A
4	liver/biliary system phenotype	MP:0005370	9.2	VEGFA, MT2A, ADM, C3AR1, AGT, PHYH
5	integument phenotype	MP:0010771	9.1	ITGB2, NR3C1, IL13, FASLG, FAS, IFNG
6	other phenotype	MP:0005395	8.8	CSF1, CXCR3, TGIF1, NOS3, NOS2, NOS1
7	renal/urinary system phenotype	MP:0005367	8.8	MYH9, GATA3, ADM, NPHS2, NPHS1, SYNPO
8	nervous system phenotype	MP:0003631	8.4	CD4, CXCL10, SYNPO, TGIF1, TGFB2, THBD
9	no phenotypic analysis	MP:0003012	8.0	PCNA, ESR1, TRADD, TNFAIP3, TNFRSF10B, TNFRSF4
10	immune system phenotype	MP:0005387	8.0	VWF, NAGLU, PATZ1, CIITA, LCN2, MT2A
11	normal phenotype	MP:0002873	7.6	FCGR2B, IL10, FASLG, IFNG, ALB, HLA-DQB1
12	reproductive system phenotype	MP:0005389	7.4	IFNG, CASP3, TNF, CCR5, PTGS2, SPP1
13	growth/size phenotype	MP:0005378	7.2	SELE, SERPINE1, NAGLU, VCAM1, BMP6, PATZ1
14	behavior/neurological phenotype	MP:0005386	7.2	IL6, NOS3, NAGLU, SELE, SPP1, SYNPO
15	adipose tissue phenotype	MP:0005375	7.0	IL18, TGFB1, C3AR1, GATA3, SERPINE1, PHYH
16	tumorigenesis	MP:0002006	7.0	CXCL16, CXCR3, CCR5, ICAM1, IFNG, ESR1
17	digestive/alimentary phenotype	MP:0005381	6.8	VWF, VEGFA, NOS1, NOS2, NOS3, EDN1
18	vision/eye phenotype	MP:0005391	6.8	CCR2, IL18, SELE, GATA3, CSF1, TGFB2
19	skeleton phenotype	MP:0005390	6.6	CASP3, FAS, IL6, IL17A, ISG15, MMP3
20	mortality/aging	MP:0010768	6.4	LCN2, IFNG, HTR1A, GLMN, HLA-DQB1, TRAF2
21	muscle phenotype	MP:0005369	6.0	TGFB1, TGFB2, SLC6A4, ADM, FADD, AGT
22	homeostasis/metabolism phenotype	MP:0005376	4.3	DDX58, STAT4, CXCL16, CXCR3, CSF1, NPHS1
23	cellular phenotype	MP:0005384	3.5	FAS, TNFRSF10B, TNFRSF11B, TNFRSF4, TNFSF10, TNFSF12
24	cardiovascular system phenotype	MP:0005385	3.5	NOS1, ADM, HGF, GATA3, MYH9, SLC6A4

Articles related to lupus nephritis:

(show top 50)    (show all 217)

id	Title	Authors	Year	Affiliating Genes
1	The possible role of ChemR23/Chemerin axis in the rec ruitment of dendritic cells in lupus nephritis. (21346723)	De Palma G.... Schena F.P.	2011	CMKLR1, RARRES2
2	Impairment of neutrophil extracellular trap degradati on is associated with lupus nephritis. (20439745)	Hakkim A.... Zychlinsky A.	2010	DNASE1
3	Role of the Fcgamma receptor IIIA-V/F158 polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta- analysis. (20059375)	Li L.H.... Ye D.Q.	2010	FCGR3A
4	Cardiac tamponade in a patient with dengue fever and lupus nephritis: a case report. (20089524)	Kumar S.... Jean R.	2010	CD40LG
5	The single nucleotide polymorphisms gene but not the copy number variation of Fcgr3B is associated with lupus nephritis in Chinese p eople. (20133350)	Yang H.... Chen J.	2010	FCGR3B
6	Expression and significance of CD80/CD86 in renal ti ssue of lupus nephritis]. (20979791)	Sui M.S.... Xie R.J.	2010	CD86, CD80
7	Expressions of IL-18 and its binding protein in perip heral blood leukocytes and kidney tissues of lupus nephritis patients. (20140691)	Hu D.... Bao C.	2010	IL18, IL18BP
8	Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations. (19387456)	Bates J.S.... Gaffney P.M.	2009	TNFAIP3
9	Decreased renal expression of vascular endothelial gr owth factor in lupus nephritis is associated with worse prognosis. (19295501)	Avihingsanon Y.... Hirankarn N.	2009	VEGFA
10	Urine osteoprotegerin and monocyte chemoattractant pr otein-1 in lupus nephritis. (19648301)	Kiani A.N.... Petri M.	2009	CCL2, TNFRSF11B
11	Current therapies for lupus nephritis in an ethnicall y heterogeneous cohort. (19040310)	Rivera T.L.... Askanase A.D.	2009	ALB
12	An acquired inhibitor to the GPVI platelet collagen r eceptor in a patient with lupus nephritis. (19583823)	Nurden P.... Nurden A.T.	2009	GP6
13	Molecular analysis of HLA-DRB1 allelic associations w ith systemic lupus erythematous and lupus nephritis in Taiwan. (19502265)	Pan C.F.... Lee Y.J.	2009	HLA-DRB1
14	Pharmacokinetics of mycophenolic acid in patients with lupus nephritis. (19113793)	Joy M.S.... Smith P.C.	2009	ALB
15	Widespread expression of inducible NOS and citrulline in lupus nephritis tissues. (19184355)	Bollain-y-Goytia J.J.... Herrera-Esparza R.	2009	NOS3, NOS2
16	Correlation of clinical and pathological findings in patients with lupus nephritis: a five-year experience in Iran. (18087120)	Nezhad S.T.... Sepaskhah R.	2008	ALB
17	The renal metallothionein expression profile is altered in human lupus nephritis. (18601746)	Faurschou M.... Jacobsen S.	2008	MT2A, MT1A
18	Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis. (18383384)	Savarese E.... Krug A.	2008	LSM2
19	Sdudy on effect of tripterygium on plasma IL-18 content in patients with lupus nephritis (18652362)	Jin C.Y.... Wang D.L.	2008	IL18
20	The novel role of neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 as a biomarker for lupus nephritis. (18190883)	Rubinstein T.... Putterman C.	2008	LCN2
21	Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis. (18980674)	Reddy P.S.... O'Toole M.	2008	MTOR
22	Association of a polymorphism in the monocyte chemoat tractant protein-1/CCL2 gene and lupus nephritis in systemic lupus erythematosu s patients. (19032843)	Hoshi D.... Kamatani N.	2008	CCL2
23	Ethnic, clinical and immunological factors in systemic lupus erythematosus and the development of lupus nephritis: results from a multi-ethnic New Zealand cohort. (17895308)	Burling F.... Gow P.	2007	CRP
24	Safety and efficacy of infliximab in a patient with active WHO class IV lupus nephritis. (16565897)	Hayat S.J.... Al-Oun M.	2007	TNF
25	Association of osteopontin gene polymorphism with lupus nephritis in Chinese Han population (17884775)	Xu A.P.... Wang Z.	2007	SPP1
26	Critical comparative analyses of anti-alpha-actinin and glomerulus-bound antibodies in human and murine lupus nephritis. (16508974)	Kalaaji M.... Rekvig O.P.	2006	DNASE1
27	Transforming growth factor beta 1 in children with systemic lupus erythematosus: a possible relation with clinical presentation of lupus nephritis. (17080918)	Hammad A.M.... El-Arman M.M.	2006	TGFB1
28	Hepatocyte growth factor prevents lupus nephritis in a murine lupus model of chronic graft-versus-host disease. (16859527)	Kuroiwa T.... Sano H.	2006	HGF
29	Evaluation of the relationship between IL-18 levels in urine and parameters of renal pathological changes in patients with lupus nephritis (17077020)	Liu H.F.... Chen X.W.	2006	IL18
30	Variations within OLF1/EBF-associated zinc finger protein gene confer susceptibility to lupus nephritis in Chinese population (16061000)	Liang D.... Qian J.	2005	OAZ1, PATZ1
31	Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis. (16034139)	Bao L.... Quigg R.J.	2005	C3AR1
32	Th1 cytokines in the pathogenesis of lupus nephritis: the role of IL-18. (16214093)	Calvani N.... Silvestris F.	2005	IL18
33	Up-regulation of IL-18 and predominance of a Th1 immune response is a hallmark of lupus nephritis. (15373921)	Calvani N.... Silvestris F.	2004	IL18
34	Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis. (15188361)	Tucci M.... Richards H.B.	2004	CCL2
35	The systemic lupus erythematosus-associated PDCD1 polymorphism PD1.3A in lupus nephritis. (14730631)	Prokunina L.... Alarcon-Riquelme M.E.	2004	PDCD1
36	Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with the development of lupus nephritis. (15119548)	Lee Y.H.... Song G.G.	2004	NOS3, NOS1
37	The Fc gamma RIIIA-F158 allele is a risk factor for the development of lupus nephritis: a meta-analysis. (12631364)	Karassa F.B.... Ioannidis J.P.	2003	FCGR3A
38	IL-17 induces autoantibody overproduction and peripheral blood mononuclear cell overexpression of IL-6 in lupus nephritis patients. (12875719)	Dong G.... Yu X.	2003	IL17A
39	Microalbuminuria and renal morphology in the evaluation of subclinical lupus nephritis. (10543324)	Valente de Almeida R.... Nisihara R.	1999	ALB
40	Highly cationic anti-DNA antibodies in patients with lupus nephritis analyzed by two-dimensional electrophoresis and immunoblotting. (9694304)	Kohro-Kawata J.... Nakamura K.	1998	DNASE1
41	Long-term treatment of lupus nephritis with cyclosporin A. (9893761)	Tam L.S.... Lui S.F.	1998	ALB
42	Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans. (8636449)	Salmon J.E.... Kimberly R.P.	1996	FCGR2A
43	Immunopathogenesis of lupus nephritis: new insights from experimental models. (8583696)	Izui S.	1995	CIITA
44	Assessment of lupus nephritis activity using urinary retinol-binding protein. (8084448)	Sesso R.... Pereira A.B.	1994	RBP4
45	Intermittent intravenous treatment of lupus nephritis with cyclophosphamide: a four-year experience with twenty-four patients. (8087706)	Chu S.J.... Chang M.L.	1994	ALB
46	Pivotal role of colony stimulating factor-1 in lupus nephritis. (8158905)	Rubin Kelley V.... Price D.	1994	CSF1
47	The change of T lymphocyte subpopulations, interleukin-2 receptor and HLA-DR antigen in lupus nephritis patients (8230356)	Yu L.... Zhang J.L.	1993	IL2RA
48	Refractory nephrotic syndrome in lupus nephritis: favorable response to indomethacin therapy. (8485564)	Espinoza L.R.... Seleznick M.	1993	ALB
49	Glucocorticoid receptor in patients with lupus nephritis: relationship between receptor levels in mononuclear leukocytes and effect of glucocorticoid therapy. (1404124)	Tanaka H.... Homma M.	1992	NR3C1
50	A case of Fabry's disease associated with lupus nephritis (1338214)	Majima K.... Kinoshita E.	1992	GLA

Genes related to lupus nephritis according to GeneCards:

(show top 50)    (show all 157)

id	Symbol	Description	Score	GeneCards Section Context
1	FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	11.0	Publications
2	C3AR1	complement component 3a receptor 1	11.0	Publications
3	CFB	complement factor B	11.0	Publications
4	CCR4	chemokine (C-C motif) receptor 4	11.0	Publications
5	FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	11.0	Publications
6	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
7	DNASE1	deoxyribonuclease I	11.0	Publications
8	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
9	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
10	C5AR1	complement component 5a receptor 1	11.0	Publications
11	CD274	CD274 molecule	11.0	Publications
12	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
13	CTSG	cathepsin G	11.0	Publications
14	DNTT	deoxynucleotidyltransferase, terminal	11.0	Publications
15	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
16	PDCD1	programmed cell death 1	11.0	Publications
17	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif, 13	11.0	Publications
18	GATA3	GATA binding protein 3	11.0	Publications
19	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0	Publications
20	CSF1	colony stimulating factor 1 (macrophage)	11.0	Publications
21	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
22	TLR9	toll-like receptor 9	11.0	Publications
23	RBP4	retinol binding protein 4, plasma	11.0	Publications
24	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
25	IL18R1	interleukin 18 receptor 1	11.0	Publications
26	CIITA	class II, major histocompatibility complex, transactivator	11.0	Publications
27	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
28	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	11.0	Publications
29	SPP1	secreted phosphoprotein 1	11.0	Publications
30	ICAM1	intercellular adhesion molecule 1	11.0	Publications
31	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
32	THBD	thrombomodulin	11.0	Publications
33	CD40LG	CD40 ligand	11.0	Publications
34	ALB	albumin	11.0	Publications
35	IL10	interleukin 10	11.0	Publications
36	TGFB1	transforming growth factor, beta 1	11.0	Publications
37	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.0	Publications
38	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
39	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
40	IL17B	interleukin 17B	11.0	Publications
41	TNFSF12	tumor necrosis factor (ligand) superfamily, member 12	11.0	Publications
42	PDCD5	programmed cell death 5	11.0	Publications
43	HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	11.0	Publications
44	TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	11.0	Publications
45	OAZ1	ornithine decarboxylase antizyme 1	11.0	Publications
46	MT1A	metallothionein 1A	11.0	Publications
47	IL20	interleukin 20	11.0	Publications
48	RARRES2	retinoic acid receptor responder (tazarotene induced) 2	11.0	Publications
49	PATZ1	POZ (BTB) and AT hook containing zinc finger 1	11.0	Publications
50	IL18BP	interleukin 18 binding protein	11.0	Publications

Pathways related to lupus nephritis according to GeneDecks:

(show top 50)    (show all 126)

id	Pathway	Score	Top Affiliating Genes
1	Staphylococcus aureus infection20	10.7	FCGR3A, FCGR2B, FCGR2A, ITGB2, CFB, FCGR3B
2	RAR-Gamma-RXR-Alpha Degradation36	10.7	CSF1, CXCL16, CXCL13, LTA, TNFSF13B, TNFSF13
3	Immune System38	10.5	CD274, CD79A, MT2A, MX1, CIITA, VCAM1
4	Cell adhesion molecules (CAMs)20	10.5	ITGB2, CD40, CD80, CD4, CD86, HLA-DPB1
5	Graft-versus-host disease20	10.2	HLA-DPB1, FASLG, CD86, HLA-DQA1, CD80
6	Intestinal immune network for IgA production20	10.0	HLA-DQA1, HLA-DPB1, ICOSLG, IL6, IL10, CD40
7	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway41	10.0	TRAF2, TNFRSF12A, TRADD, TNF, TNFSF12, TNFSF4
8	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway10	9.9	TRAF2, CD40LG, TNFSF12, TNFRSF12A, TNFSF4, TNFSF13
9	Th1 Differentiation37	9.9	CD86, STAT4, TLR9, IFNG, TNF, IL18R1
10	IL-6 Pathway36	9.9	CD80, BMP6, CXCL13, IL10, CXCL10, TNFSF4
11	Rho Family GTPases36	9.8	HGF, CSF1, CXCL13, CXCL10, IL18, IL13
12	Akt Signaling36	9.8	TNFSF13B, HGF, CSF1, CXCR3, CXCL16, CXCL10
13	Systemic lupus erythematosus20	9.8	C4A, CTSG, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1
14	TNF Superfamily Pathway36	9.7	LTA, TNFSF4, TNFSF13B, TNFSF13, TNFSF12, TNFSF10
15	Malaria20	9.7	TGFB1, TLR9, CR1, TNF, ICAM1, IFNG
16	PGC1Alpha Pathway36	9.7	TNFSF13B, TNFSF10, TNFRSF10B, TNFRSF10A, CCL5, CCL3
17	THC Differentiation Pathway36	9.6	IL18R1, IFNG, HLA-DQB1, HLA-DQA1, HLA-DRB1, IL2RA
18	NFAT Signaling and Lymphocyte Interactions36	9.6	IL13, TNFSF13B, BMP6, CD4, CD80, IL11
19	Autoimmune thyroid disease20	9.5	HLA-DRB1, HLA-DQB1, HLA-DPB1, CD86, CD40LG, CD80
20	Allograft rejection20	9.4	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, IFNG, FAS
21	TGF-Beta Pathway36	9.3	IL13, IL11, IL10RA, IL10, CD80, CD4
22	African trypanosomiasis20	9.3	ICAM1, SELE, IL18, IL6, VCAM1, FASLG
23	Apoptosis and survival Apoptotic TNF-family pathways10	9.2	TNFSF10, TNFSF12, TNFRSF10B, TNFRSF10A, TNF, TRADD
24	Apoptosis and survival_Apoptotic TNF-family pathways41	9.2	TNF, TRAF2, CASP3, FAS, FADD, FASLG
25	JNK Pathway36	9.2	BMP6, CD4, CD80, IL18R1, IL2RA, IL6
26	Apoptosis Signaling Pathways37	9.2	TNFRSF12A, TNFRSF10A, TNFSF12, TNFSF10, TNFRSF10B, TNF
27	Toxoplasmosis20	9.1	CASP3, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF
28	Glucocorticoid Receptor Signaling36	9.0	TGFB1, IL13, IL11, IL10RA, IL10, FKBP4
29	PEDF Induced Signaling36	9.0	IL10, IL11, IL13, IL18, IL20, IL6
30	MAPK Family Pathway36	9.0	HGF, TGFB2, TGFB1, LTA, TNFSF13B, TNFSF10
31	Tec Kinases Signaling36	8.9	TNFSF12, TNFSF10, TNFRSF4, TNFRSF12A, TNFRSF10B, TNFRSF10A
32	Chagas disease (American trypanosomiasis)20	8.9	TGFB2, TGFB1, TLR9, ACE, NOS2, TNF
33	ERK Signaling36	8.9	ESR1, CCL5, CCL3, IL6, IL20, IL18
34	Endothelin-1 Signaling Pathway36	8.8	BMP6, CASP3, CCL5, CCL3, IL6, IL20
35	Measles20	8.8	MX1, FCGR2B, TLR9, IL13, IL2RA, TNFSF10
36	Antioxidant Action of Vitamin-C36	8.8	TNFSF13, TNFSF12, TNFSF10, TNFRSF4, TNFRSF12A, TNFRSF10B
37	STAT3 Pathway36	8.8	TNFRSF12A, IL18, IL13, IL11, IL10RA, IL10
38	Leishmaniasis20	8.7	PTGS2, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1
39	Molecular Mechanisms of Cancer36	8.7	TNFSF13B, TNFSF12, TNFSF10, TNFRSF4, TNFRSF10B, TNFRSF10A
40	Influenza A20	8.7	TNFRSF10A, IL18, MX1, CIITA, IL6, FASLG
41	Type I diabetes mellitus20	8.6	CD86, TNF, CD80, LTA, HLA-DQB1, HLA-DQA1
42	PAK Pathway36	8.6	CCL2, MYH9, CASP3, CCL5, CCL3, CSF1
43	Rheumatoid arthritis20	8.6	CD86, VEGFA, CD80, HLA-DPB1, ICAM1, IFNG
44	Tuberculosis20	8.6	CIITA, ITGB2, CASP3, IFNG, IFNA1, FADD
45	p38 Signaling36	8.5	CASP3, IL18R1, IL18, CCL5, CCL3, CCR5
46	all-trans-Retinoic Acid Signaling in Brain36	8.3	HGF, CSF1, CXCL16, CXCL13, CXCL10, LTA
47	MIF Regulation of Innate Immune Cells36	8.2	CXCL13, CXCL10, LTA, PTGS2, TNFSF4, CXCL16
48	JAK-STAT Pathway36	8.2	STAT4, TGFB2, TGFB1, AGTR1, AGT, TNFSF13B
49	MIF Mediated Glucocorticoid Regulation36	8.0	CSF1, CCL3, CCL2, IL6, IL20, IL18
50	Cytokine-cytokine receptor interaction20	7.9	TGFB1, LTA, TNFSF4, TNFSF13B, TNFSF13, TNFSF12

Compounds related to lupus nephritis according to GeneDecks:

(show top 50)    (show all 504)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	14.0	ITGB2, APOH, NPHS2
2	ionomycin32	10.9	CD274, CD40, CCL3, TNFRSF4, GATA3
3	threonine32	10.5	CD4, IL1RAPL2, GLA, CTSG, LTA, C3AR1
4	endotoxin32	10.3	CIITA, CD86, CD40, ITGB2, IL18, IL18BP
5	groalpha32	9.9	SELE, VCAM1, IL10, IL13, IL17A, IL18
6	ascorbic acid32 18	10.9	PCNA, RBP4, CD40LG, IL2RA, FASLG, FAS
7	cytochalasin d32 42	10.8	VWF, SELE, VCAM1, ITGB2, MMP3, FCGR2A
8	pmma32	9.7	BMP6, B2M, CD40LG, CCL3, CCL5, TNFRSF11B
9	l-nmma32	9.7	VCAM1, IL1RN, NOS1, NOS2, COX5A, EDN1
10	rapamycin32 42	10.6	VEGFA, MTOR, CD86, CD80, FKBP4, IL18R1
11	pravastatin32 34 9 18 9	13.6	SELE, SERPINE1, IL18, IL6, CCL2, CYP2B6
12	zidovudine32 9 9	11.6	B2M, CD4, IL10, CCL2, CCR5, CCL3
13	homocysteine32 18	10.5	VWF, SELE, SERPINE1, NAGLU, VCAM1, IL18
14	tarc32	9.5	CD4, IL10, IL13, IL18, CCL2, CCR4
15	leukotriene b432 42 18	11.3	LCN2, ITGB2, FCGR3B, IL11, IL13, IL1RAPL2
16	sulfasalazine32 9 9	11.3	SELE, CD79A, CD40LG, MMP3, IL1RAPL2, IL1RN
17	progesterone32 42 9 18 9	13.3	PCNA, RBP4, CDKN1A, ISG15, FKBP4, ANXA2
18	nifedipine32 9 9	11.1	SELE, SERPINE1, NAGLU, BMP6, B2M, CD40
19	fluvastatin32 34 9 9	12.1	VWF, SERPINE1, VCAM1, CD40, IL6, CCL2
20	cysteine32	9.0	PCNA, RBP4, NAGLU, RARRES2, MT2A, CD79A
21	pentoxifylline32 9 9	10.9	NAGLU, VCAM1, BMP6, ITGB2, IL10, IL13
22	ccl332	8.9	IL10, IL11, IL13, IL18, IL6, CCL2
23	8-isoprostane32	8.9	SELE, SERPINE1, VCAM1, IL10, IL6, APOH
24	perindopril32 34 9 9	11.9	VWF, SERPINE1, NAGLU, VEGFA, ALB, CRP
25	superoxide32 18	9.7	NAGLU, VCAM1, LCN2, MT2A, CD40, ITGB2
26	il 1032	8.5	BMP6, CD40, IL10, IL10RA, IL13, IL18
27	txb232	8.5	VWF, NAGLU, B2M, IL11, IL1RAPL2, IL1RN
28	rosiglitazone32 9 18 9	11.5	RBP4, SELE, SERPINE1, VCAM1, LCN2, CDKN1A
29	etanercept32 9 9	10.5	MMP3, FCGR2A, FCGR2B, FCGR3A, FCGR3B, IL10
30	testosterone32 9 18 9	11.2	PCNA, SELE, VCAM1, MTOR, B2M, CD79A
31	pdtc32	7.9	SELE, VCAM1, CDKN1A, CD40, IL18, IL6
32	infliximab32 9 9	9.8	SELE, VEGFA, MMP3, IL10, IL11, IL17A
33	vitamin d32	7.7	SERPINE1, NAGLU, BMP6, B2M, CD79A, CDKN1A
34	phosphatidylinositol32	7.7	VCAM1, BMP6, CIITA, MTOR, CD4, CD80
35	ly29400232	7.7	SELE, VEGFA, ITGB2, FCGR2A, IL10, IL13
36	curcumin32	7.7	VEGFA, VCAM1, CDKN1A, MMP3, IL17A, IL18
37	celecoxib32 42 34 9 18 9	12.6	PCNA, VEGFA, CDKN1A, MMP3, MKI67, CCL3
38	norepinephrine32 9 18 9	10.5	VWF, SELE, VCAM1, BMP6, CD79A, CD40LG
39	creatinine32	7.5	VWF, PCNA, RBP4, SELE, NAGLU, BMP6
40	troglitazone32 42 9 9	10.4	SELE, SERPINE1, VCAM1, BMP6, CDKN1A, MMP3
41	arachidonic acid32 9 18 9	10.4	VWF, MTOR, CD4, FCGR2A, IL11, IL13
42	atorvastatin32 34 9 18 9	11.2	VWF, SELE, SERPINE1, VEGFA, VCAM1, BMP6
43	methotrexate32 34 42 9 9	10.9	PCNA, SELE, SERPINE1, NAGLU, BMP6, MT2A
44	pd 98,05932	6.9	SERPINE1, VCAM1, BMP6, MTOR, CDKN1A, CD40
45	15-deoxy-delta-12,14-prostaglandin j232	6.8	SERPINE1, VEGFA, VCAM1, BMP6, CDKN1A, IL10
46	thymidine32 18	7.7	PCNA, NAGLU, BMP6, CIITA, B2M, CDKN1A
47	simvastatin32 34 42 9 18 9	11.4	VWF, RBP4, SELE, SERPINE1, VEGFA, VCAM1
48	tamoxifen32 34 9 9	9.0	PCNA, SELE, VEGFA, VCAM1, BMP6, MTOR
49	vegf32	5.8	VWF, PCNA, SELE, SERPINE1, VCAM1, MTOR
50	tyrosine32	5.5	PDCD1, VWF, VEGFA, VCAM1, BMP6, CIITA

Cellular components related to lupus nephritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endocytic vesicle membrane	GO:030666	9.8	RPS27A, HLA-DPB1, HLA-DQA1, HLA-DQB1, NOS3, HLA-DRB1
2	cell surface	GO:009986	9.6	TGFB1, ADAMTS13, TGFB2, THBD, VEGFA, VCAM1
3	integral to plasma membrane	GO:005887	9.4	CD40LG, CMKLR1, NPHS2, CD40, FASLG, CCR2
4	platelet alpha granule lumen	GO:031093	9.2	HGF, VWF, SERPINE1, VEGFA, FGB, TGFB1
5	membrane raft	GO:045121	9.0	CD4, CD79A, FAS, SLC6A4, SELE, TRAF2
6	external side of plasma membrane	GO:009897	8.5	FAS, FASLG, IL17A, IL13, FCGR3A, FGB
7	plasma membrane	GO:005886	7.2	TLR9, AGTR1, ACE, C4B, C4A, RPS27A
8	extracellular region	GO:005576	7.1	VWF, IL6, FASLG, FAS, CCL2, CCL3
9	extracellular space	GO:005615	6.6	IL1RN, TNFSF4, SPP1, CTSG, CRP, LTA

Biological processes related to lupus nephritis according to GeneDecks:

(show top 50)    (show all 89)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine-mediated signaling pathway	GO:070098	11.0	CCR2, CMKLR1, CCL2, CCR4, CCR5, CCL5
2	positive regulation of macrophage chemotaxis	GO:010759	10.9	CCL5, CMKLR1, RARRES2, CCL2, C3AR1
3	chemotaxis	GO:006935	10.9	CCL2, CMKLR1, C5AR1, C3AR1, C5, CXCL16
4	cellular response to tumor necrosis factor	GO:071356	10.7	EDN1, IL18BP, ANKRD1, CCL2, CCL3, CCL5
5	cellular calcium ion homeostasis	GO:006874	10.7	CCL5, TGFB1, HERPUD1, C5, CCR2, CCL3
6	leukocyte cell-cell adhesion	GO:007159	10.6	ICAM1, ITGB2, SELE, VCAM1, CD40LG, CCL5
7	cellular response to interleukin-1	GO:071347	10.5	EDN1, IL17A, ANKRD1, CCL2, CCL3, CCL5
8	elevation of cytosolic calcium ion concentration	GO:007204	10.4	CCR2, ADM, C3AR1, C5AR1, EDN1, CXCL13
9	positive regulation of inflammatory response	GO:050729	10.4	AGT, AGTR1, TNFSF4, CCL3, CCR2, SERPINE1
10	positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	10.4	TNFSF10, TNFRSF12A, TRAF2, FADD, TNFSF12
11	cellular response to mechanical stimulus	GO:071260	10.3	CD40, FAS, IL13, TNFRSF10A, TNFRSF10B, ANKRD1
12	lipopolysaccharide-mediated signaling pathway	GO:031663	10.3	NOS3, IL18, CCL2, CCL3, TNF, TGFB1
13	cellular response to lipopolysaccharide	GO:071222	10.2	ICAM1, TNFSF4, NOS2, IL10, TNFAIP3, SERPINE1
14	innate immune response	GO:045087	10.2	LCN2, MX1, IL1RAPL2, CCR2, FADD, IL18R1
15	neutrophil chemotaxis	GO:030593	10.2	IFNG, ITGB2, CCL2, CCL3, SPP1, EDN1
16	T cell costimulation	GO:031295	10.2	HLA-DRB1, HLA-DQB1, HLA-DQA1, ICOSLG, MTOR, CD86
17	regulation of immunoglobulin secretion	GO:051023	10.2	TNF, TRAF2, CD40, CD40LG
18	activation of pro-apoptotic gene products	GO:008633	10.2	TRADD, FAS, FADD, FASLG, TRAF2, TNFRSF10B
19	aging	GO:007568	10.1	FAS, TGFB2, CCL2, ADM, TGFB1, AGT
20	interferon-gamma-mediated signaling pathway	GO:060333	10.1	HLA-DQB1, MT2A, IFNG, HLA-DPB1, HLA-DQA1, HLA-DRB1
21	organ regeneration	GO:031100	10.0	CDKN1A, MKI67, APOH, CCL2, TGFB1, ADM
22	defense response to virus	GO:051607	10.0	DDX41, CXCL10, OAS1, IFNG, FADD, IL6
23	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.9	TRAF2, TNF, AGT, TLR9, TRAF1, ICAM1
24	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.9	TRAF1, TNFSF10, CD40, FADD, TLR9, TRADD
25	cell-cell signaling	GO:007267	9.9	IL13, IL11, IL10, ISG15, ITGB2, CD80
26	positive regulation of interferon-gamma production	GO:032729	9.8	IL18, CCR2, TNF, TNFSF4, LTA, CD40LG
27	humoral immune response	GO:006959	9.8	IL6, PDCD1, CCL2, IFNG, LTA, TNF
28	angiogenesis	GO:001525	9.8	VEGFA, IL18, NOS3, ANXA2, CCL2, TNFRSF12A
29	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.7	TNF, TRADD, TRAF2, FAS, FADD, TNFRSF10A
30	induction of apoptosis via death domain receptors	GO:008625	9.7	FASLG, FADD, FAS, TNF, CASP3, TNFRSF10B
31	positive regulation of neuron apoptotic process	GO:043525	9.7	NR3C1, TNF, CASP3, CCL3, FASLG, IL18
32	calcium-mediated signaling	GO:019722	9.7	TNF, EDN1, CCR5, CXCR3, AGTR1, SELE
33	positive regulation of angiogenesis	GO:045766	9.6	SERPINE1, VEGFA, CCL5, TNFSF12, NOS3, C5
34	cytokine-mediated signaling pathway	GO:019221	9.6	ICAM1, CCL2, HLA-DQA1, VCAM1, CIITA, MT2A
35	induction of apoptosis	GO:006917	9.5	TNFSF10, PDCD5, MX1, FASLG, FAS, C5
36	induction of apoptosis by extracellular signals	GO:008624	9.5	RPS27A, TNFSF12, TNFSF10, FASLG, TNF, TRADD
37	immune response	GO:006955	9.5	CCR2, CCR4, CCR5, HLA-DQA1, HLA-DQB1, HLA-DRB1
38	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.3	IL6, VEGFA, MTOR, CD4, CD80, AGT
39	platelet activation	GO:030168	9.2	IL11, HGF, FGB, TGFB2, TGFB1, ALB
40	positive regulation of cell proliferation	GO:008284	9.2	HTR1A, CSF1, CXCL10, VEGFA, CD86, IL11
41	platelet degranulation	GO:002576	9.2	TGFB2, TGFB1, ALB, FGB, VEGFA, SERPINE1
42	response to lipopolysaccharide	GO:032496	9.1	CTSG, IL13, IL18BP, FASLG, PTGS2, FAS
43	response to glucocorticoid stimulus	GO:051384	8.9	PTGS2, TNF, CCL5, FAS, IL6, IL10
44	signal transduction	GO:007165	8.9	MTOR, CD4, PDCD1, MX1, NR3C1, TNFRSF10A
45	response to hypoxia	GO:001666	8.5	EDN1, IL18, VCAM1, VEGFA, ADM, SLC6A4
46	inflammatory response	GO:006954	8.4	CCL2, CCR4, CCR5, CCL3, CCL5, TNF
47	positive regulation of nitric oxide biosynthetic process	GO:045429	8.3	ESR1, IFNG, ICAM1, EDN1, PTGS2, TNF
48	response to drug	GO:042493	8.0	TNFRSF11B, CCL5, PTGS2, ICAM1, NOS3, TNF
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.7	IL17A, FADD, ANKRD1, IFNG, TNF, NOS1
50	apoptotic process	GO:006915	INF	IFNG, TRAF2, TRAF1, LCN2, ITGB2, IL17A

Molecular functions related to lupus nephritis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	IgG binding	GO:019864	10.7	FCGR2A, FCGR2B, FCGR3A, FCGR3B, FCGRT
2	chemokine receptor activity	GO:004950	10.5	CCR2, CXCR3, CCR5, CCR4, CMKLR1
3	chemokine activity	GO:008009	10.4	C5, CXCL16, CXCL13, CXCL10, CCL5, CCL3
4	receptor activity	GO:004872	10.1	FAS, IL18R1, IL10RA, FCGRT, ITGB2, CD40
5	tumor necrosis factor receptor binding	GO:005164	10.0	FASLG, TRAF2, FADD, TNF, TNFSF10, TNFSF12
6	receptor binding	GO:005102	9.8	SERPINE1, TNFSF12, TNFSF10, GLA, ICOSLG, CCL2
7	tetrahydrobiopterin binding	GO:034617	9.8	NOS2, NOS1, NOS3
8	nitric-oxide synthase activity	GO:004517	9.6	NOS1, NOS2, NOS3
9	growth factor activity	GO:008083	9.0	AGT, IL6, TGFB2, IL10, BMP6, VEGFA
10	heme binding	GO:020037	8.7	PTGS2, NOS3, NOS2, NOS1, CYP2C9, CYP3A5
11	cytokine activity	GO:005125	7.9	IL17B, IL17A, IL13, IL11, CD40LG, BMP6
12	protein binding	GO:005515	4.1	IRF5, GP6, MKI67, FCGR2B, IL10RA, FKBP4