MCID: LPS007
MIFTS: 55

Lupus Nephritis malady

Summaries for Lupus Nephritis

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Lupus nephritis is a kidney disorder that is a complication of systemic lupus erythematous (sle), commonly known as lupus. the symptoms of lupus nephritis include blood in the urine, a foamy appearance to the urine, high blood pressure, and swelling in any part of the body. this condition typically occurs in people aged 20 to 40 years. treatment may involve medications to suppress the immune system, dialysis, or a kidney transplant. visit our web page on lupus for more information and resources. last updated: 11/24/2010

MalaCards: Lupus Nephritis is related to nephritis and systemic lupus erythematosus. An important gene associated with Lupus Nephritis is FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)), and among its related pathways are Signaling by GPCR and Akt Signaling. The drug cyclophosphamide and the compounds calcium and lipid have been mentioned in the context of this disorder. Affiliated tissues include whole blood, heart and kidney, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:64 Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE), a disease... more...

Aliases & Classifications for Lupus Nephritis

Sources:
43NIH Rare Diseases, 47OMIM, 45Novoseek, 61UMLS
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Aliases & Descriptions:

lupus nephritis 43 47 45 61


Related Diseases for Lupus Nephritis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lupus Nephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 211)
idRelated DiseaseScoreTop Affiliating Genes
1nephritis32.2APOH, FCGR3A, CXCR3, RBP4, GATA3, CCL2
2systemic lupus erythematosus31.3CCR4, APOH, CTSG, GATA3, RBP4, DNASE1
3vasculitis30.6CCL2, CTSG, VCAM1, THBD, APOH
4arthritis30.5FCGR2A, CCL5, CCL2, CSF1, CTSG, CXCR3
5antiphospholipid syndrome30.4VCAM1, THBD, APOH
6thrombocytopenia30.3CSF1, THBD, FCGR3A, FCGR2A, APOH
7atherosclerosis30.0CD40, CCL5, CCL2, TLR9, CSF1, RBP4
8tuberculosis30.0TLR9, IL18, DNASE1, CCR4, CTSG, CXCR3
9hepatitis c30.0RBP4, CXCR3, IL18
10rheumatic disease30.0CXCR3, IL18, FCGR2A, APOH
11eclampsia30.0THBD
12vascular disease30.0CCL2, APOH, THBD, VCAM1
13sickle cell disease30.0VCAM1
14n syndrome10.6
15membranous glomerulonephritis10.3
16membranoproliferative glomerulonephritis10.3
17lip disease10.3
18bullous systemic lupus erythematosus10.3
19graft versus host disease10.2
20crescentic glomerulonephritis10.2
21focal segmental glomerulosclerosis10.2
22central nervous system lymphoma10.2
23proliferative glomerulonephritis10.2
24thrombotic thrombocytopenic purpura10.2
25renal tubular acidosis10.2
26focal glomerulosclerosis10.2
27chronic graft versus host disease10.2
28systemic lupus erythematosus 210.2
29diffuse alveolar hemorrhage10.2
30hellp syndrome10.0
31cardiac tamponade10.0
32periarthritis10.0
33myelitis10.0
34lemierre's syndrome10.0
35hepatitis e10.0
36coccidioidomycosis10.0
37juvenile myelomonocytic leukemia10.0
38cavernous sinus thrombosis10.0
39rapidly progressive glomerulonephritis10.0
40calciphylaxis10.0
41oculocutaneous albinism10.0
42refsum disease10.0
43nocardiosis10.0
44cystinosis10.0
45ovarian hyperstimulation syndrome10.0
46protein-losing enteropathy10.0
47autoimmune hemolytic anemia10.0
48multicentric reticulohistiocytosis10.0
49septic arthritis10.0
50fabry disease10.0

Graphical network of the top 20 diseases related to Lupus Nephritis:



Diseases related to lupus nephritis

Clinical Features for Lupus Nephritis

Drugs & Therapeutics for Lupus Nephritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lupus Nephritis

Drug clinical trials:

Search ClinicalTrials for Lupus Nephritis

Search NIH Clinical Center for Lupus Nephritis

Search CenterWatch for Lupus Nephritis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Lupus Nephritis

Anatomical Context for Lupus Nephritis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Lupus Nephritis:

33
Whole blood, Heart, Kidney, Liver, Skin, Monocytes, T cells, B cells, Endothelial, Fetal liver

Animal Models for Lupus Nephritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Lupus Nephritis

Sources:
51PubMed
See all sources

Articles related to Lupus Nephritis:

(show top 50)    (show all 819)
idTitleAuthorsYear
1
Urinary CD4 T cells identify SLE patients with proliferative lupus nephritis and can be used to monitor treatment response. (23475982)
2014
2
ABIN1 dysfunction as a genetic basis for lupus nephritis. (23970121)
2013
3
Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among US adults with Medicaid coverage, 2000-2004. (23203603)
2013
4
Tubulointerstitial nephritis in systemic lupus erythematosus innocent bystander or ominous presage. (24288339)
2013
5
Efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients. (23944610)
2013
6
Pathogenesis and significance of glomerular C4d deposition in lupus nephritis: activation of classical and lectin pathways. (24133594)
2013
7
Nucleosomes contribute to increase mesangial cell chemokine expression during the development of lupus nephritis. (23561928)
2013
8
FcI^RIIIa SNPs and haplotypes affect human IgG binding and association with lupus nephritis in African Americans. (24375423)
2013
9
Immunological aspects of biopsy-proven lupus nephritis in Bahraini patients with systemic lupus erythematosus. (24231503)
2013
10
Renoprotective strategies in lupus nephritis: beyond immunosuppression. (24097999)
2013
11
Mycophenolate mofetil versus azathioprine as maintenance therapy for lupus nephritis: a meta-analysis. (23113811)
2013
12
Efficacy of weekly mizoribine pulse therapy in refractory lupus nephritis. (22526831)
2013
13
Late onset lupus nephritis: analysis of clinical manifestations and renal pathological features in Siriraj Hospital. (22574552)
2012
14
Diffuse proliferative crescentic lupus nephritis with normal renal function. (22382232)
2012
15
Maternal deaths in women with lupus nephritis: a review of published evidence. (22311940)
2012
16
Repeat kidney biopsies fail to detect differences between azathioprine and mycophenolate mofetil maintenance therapy for lupus nephritis: data from the MAINTAIN Nephritis Trial. (22110048)
2012
17
Impact of recurrent lupus nephritis on lupus kidney transplantation: a 20-year single center experience. (22215121)
2012
18
A girl with difficult lupus nephritis: lupus vasculopathy. (23135867)
2012
19
Combination of anti-C1q and anti-dsDNA antibodies is associated with higher renal disease activity and predicts renal prognosis of patients with lupus nephritis. (22700716)
2012
20
Biochemical analysis of the epitope specificities of anti-C1q autoantibodies accompanying human lupus nephritis reveals them as a dynamic population in the course of the disease. (22981967)
2012
21
HMGB1: a smoking gun in lupus nephritis? (22423653)
2012
22
Predictors of survival in Chinese patients with lupus nephritis. (22513365)
2012
23
Population pharmacokinetics of mycophenolate mofetil in Thai lupus nephritis patients. (22456298)
2012
24
Renal vein thrombosis with pulmonary embolism: first manifestation of lupus nephritis. (21599786)
2011
25
Molecular evaluation of renal biopsies: a search for predictive and prognostic markers in lupus nephritis. (21745010)
2011
26
Epidemiology and management of refractory lupus nephritis. (21565286)
2011
27
Variation in initial kidney replacement therapy for end-stage renal disease due to lupus nephritis in the United States. (22058067)
2011
28
The involvement of immune semaphorins and neuropilin-1 in lupus nephritis. (21951945)
2011
29
Correlations of urinary biomarkers, TNF-like weak inducer of apoptosis (TWEAK), osteoprotegerin (OPG), monocyte chemoattractant protein-1 (MCP-1), and IL-8 with lupus nephritis. (21691937)
2011
30
Effect of artemisinin combined with glucocorticoid on the expressions of glucocorticoid receptor I+ mRNA, glucocorticoid receptor I^ mRNA and P300/CBP protein in lupus nephritis mice. (21509671)
2011
31
Interleukin-10 receptor expression and signalling were down-regulated in CD4a8_ T cells of lupus nephritis patients. (21635228)
2011
32
Acquired loss of renal nuclease activity is restricted to DNaseI and is an organ-selective feature in murine lupus nephritis. (21723244)
2011
33
Connective tissue diseases: Therapeutic targeting of chromatin in lupus nephritis? (21491651)
2011
34
Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis. (22031763)
2011
35
Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. (20439745)
2010
36
Association between anti-beta2 glycoprotein I antibodies and renal glomerular C4d deposition in lupus nephritis patients with glomerular microthrombosis: a prospective study of 155 cases. (20504833)
2010
37
Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis. (20003354)
2009
38
ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai. (19286673)
2009
39
Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis. (17785315)
2007
40
C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist. (16052609)
2005
41
Expression of monocyte chemoattractant protein-1 and lupus nephritis]. (16178446)
2005
42
Antiphospholipid antibodies in patients with lupus nephritis. (14575283)
2003
43
Transverse myelitis in a patient with severe lupus nephritis: a case report. (17660673)
2002
44
Antigens of antineutrophil cytoplasmic autoantibodies in recognizing a novel neutrophil granule antigen in lupus nephritis and its association with photosensitivity and oral ulceration]. (12485525)
2002
45
Tubular lesions and tubular cell adhesion molecules for the prognosis of lupus nephritis. (11737595)
2001
46
Preservation of intercalated cell H(+)-ATPase in two patients with lupus nephritis and hyperkalemic distal renal tubular acidosis. (9219160)
1997
47
Intravenous immune globulin therapy of lupus nephritis: use of pathogenic anti-DNA-reactive IgG. (8625551)
1996
48
Expression of intercellular adhesion molecule-1 and vascular adhesion molecule-1 in kidney of patients with lupus nephritis and membranoproliferative glomerulonephritis]. (7544695)
1995
49
Anti-5S RNA/protein (RNP) antibody levels correlate with disease activity in a patient with systemic lupus erythematosus (SLE) nephritis. (8137536)
1994
50
Antiproteinuric effect of captopril in a patient with lupus nephritis and intractable nephrotic syndrome. (2241292)
1990

Genetic Variations for Lupus Nephritis

Expression for genes affiliated with Lupus Nephritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lupus Nephritis

Search GEO for disease gene expression data for Lupus Nephritis.

Pathways for genes affiliated with Lupus Nephritis

Sources:
54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 53R&D Systems
See all sources

Pathways related to Lupus Nephritis according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9CCR4, CCL5, CCL2, TLR9, RBP4, CXCR3
2
Hide members
10.8CCR4, CCL5, CCL2, TLR9, CSF1, CXCR3
3
Hide members
10.8CCR4, CCL5, CCL2, CTSG, CXCR3, C3AR1
4
Hide members
10.8CCR4, CCL5, CCL2, CSF1, CXCR3, IL18
5
Hide members
10.7GATA3, CD40, IL18, FCGR2A, FCGR3A
6
Hide members
10.7CCR4, CCL5, CCL2, CXCR3, VCAM1
710.7FCGR3A, FCGR2A, IL18, TLR9
8
Hide members
10.7CTSG, CD40, FCGR2A, FCGR3A
9
Hide members
10.7VCAM1, FCGR3A, FCGR2A, CD40
10
Hide members
10.7CCL5, CCL2, TLR9, CD40
1110.7CCR4, CCL5, CCL2, CXCR3
12
Hide members
10.7CXCR3, CCL2, CCL5, CCR4
1310.7VCAM1, CSF1, CCL2, CCL5
14
Hide members
10.7CCR4, CSF1, CD40, CXCR3
1510.6C3AR1, FCGR3A, FCGR2A
1610.6CCL2, CD40, C3AR1
1710.6IL18, CD40, TLR9
1810.6VCAM1, IL18, TLR9
19
Hide members
10.6IL18, CCL2, CCL5
2010.6CCL2, CSF1, IL18
21
Hide members
10.6TLR9, GATA3, IL18
2210.6VCAM1, CSF1, CCL2
2310.5IL18

Compounds for genes affiliated with Lupus Nephritis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Lupus Nephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2414.7CCR4, C3AR1, FCGR3A, FCGR2A, IL18, CCL5
2lipid4511.5CCL5, CCL2, RBP4, CD40, NAGLU, IL18
3creatinine4511.5CXCR3, CCL5, CCL2, CSF1, APOH, CTSG
4cholesterol45 29 11 2414.5RBP4, CCL2, CCL5, FCGR3A, APOH, THBD
5nitric oxide45 11 2413.5CTSG, CXCR3, CD274, CD40, NAGLU, THBD
6tyrosine4511.5TLR9, CSF1, GATA3, CD40, CXCR3, IL18
7histamine45 29 2413.5C3AR1, CCL5, CCL2, CD40, VCAM1, THBD
8retinoic acid45 2412.4VCAM1, THBD, IL18, CD40, CCR4, CCL5
9lactate4511.4VCAM1, CCL5, RBP4, THBD, CTSG, APOH
10serine4511.4CCL5, RBP4, CCL2, CSF1, CXCR3, IL18
11arginine4511.4CXCR3, CTSG, APOH, CSF1, CCL2, FCGR3A
12simvastatin45 50 60 29 11 2416.3CCR4, CCL5, CCL2, RBP4, CD40, IL18
13heparin45 29 11 2414.3CCL5, CSF1, APOH, CTSG, NAGLU, CXCR3
14fmlp4511.3VCAM1, FCGR2A, C3AR1, CXCR3, CTSG, CSF1
15n acetylcysteine4511.3CD40, DNASE1, CCL5, CCL2, NAGLU, IL18
16ly2940024511.2IL18, CD40, FCGR2A, VCAM1, CSF1, CCL2
17homocysteine45 2412.2CCL2, APOH, NAGLU, VCAM1, CCL5, THBD
18prednisolone45 29 1113.2THBD, CCR4, CD40, FCGR2A, CSF1, APOH
19paraffin4511.2CCL2, CSF1, CTSG, DNASE1, CD40, THBD
20etanercept45 50 1113.2FCGR3A, FCGR2A, IL18, APOH, CSF1, CXCR3
21prostacyclin4511.2CSF1, APOH, CTSG, FCGR2A, THBD, CCL2
22ionomycin4511.2CCL5, CSF1, IL18, CD40, CD274, GATA3
23vegf4511.2CXCR3, IL18, THBD, CSF1, VCAM1, CD40
24il 104511.2CCL5, IL18, CXCR3, CD40, CSF1, CCL2
25h2o24511.2THBD, CTSG, DNASE1, CD40, NAGLU, IL18
26endotoxin4511.2APOH, CTSG, CXCR3, THBD, VCAM1
27ccl345 2912.2CCR4, CCL5, CCL2, TLR9, CXCR3, IL18
28aspartate4511.2VCAM1, NAGLU, DNASE1, RBP4, CTSG, CCL2
29zinc45 2412.1APOH, CD40, DNASE1, RBP4, NAGLU, GATA3
30dexamethasone45 50 29 1114.1RBP4, GATA3, CCL5, DNASE1
31polysaccharide4511.1DNASE1, CCL2, THBD, CTSG, VCAM1, IL18
32cyclophosphamide45 50 1113.1THBD, NAGLU, CD40, APOH
33groalpha4511.1CCL2, CXCR3, CCL5, IL18, VCAM1
34glucose4511.1THBD, APOH, RBP4, CCL5, CD40, NAGLU
35rantes4511.1CSF1, CD40, CXCR3
36polyinosinic-polycytidylic acid4511.1VCAM1, IL18, TLR9, CD40, CSF1
37oxygen45 2412.0CD40, CCL2, RBP4, NAGLU, FCGR3A
38alanine4511.0DNASE1, THBD, CSF1, CCL5, IL18, CTSG
39fibrinogen4511.0CTSG, APOH, CCL2, THBD, VCAM1, IL18
40superoxide45 2412.0VCAM1, APOH, CXCR3, CD40, CCL2
41tarc4511.0CCL2, CCL5, CCR4, IL18, CXCR3
42ivig4511.0APOH, FCGR3A, FCGR2A, CD40, CSF1
43fluvastatin45 50 29 1113.9CD40, IL18, THBD, CCL2, VCAM1
44estrogen4510.8APOH
45wortmannin4510.8CCL5, CCL2, VCAM1, CD40, CXCR3, FCGR2A
46pd 98,0594510.8CSF1, VCAM1, IL18, CD40, CCL5, CCL2
47larc4510.8CCL5, CCR4, CXCR3, CCL2
48neopterin4510.8IL18, THBD, CD40, CSF1, NAGLU
49rituximab45 50 1112.6APOH, CSF1, CD40, FCGR2A, FCGR3A
50folate4510.5CCL5, VCAM1, IL18, APOH, RBP4, THBD

GO Terms for genes affiliated with Lupus Nephritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Lupus Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.1TLR9, CSF1, CTSG, CD274, CD40, CXCR3
2extracellular spaceGO:00561510.8CCL5, CCL2, CSF1, APOH, CTSG, RBP4
3external side of plasma membraneGO:00989710.8VCAM1, CCR4, CD274, CD40, CXCR3, FCGR3A
4extracellular regionGO:00557610.6CCL5, CCL2, TLR9, CTSG, RBP4, DNASE1

Biological processes related to Lupus Nephritis according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.3C3AR1, CCR4, CCL5, CCL2, TLR9, CSF1
2chemotaxisGO:00693511.1CCR4, CCL5, CCL2, CXCR3, C3AR1
3cellular response to tumor necrosis factorGO:07135611.0CCL5, CCL2, GATA3, IL18
4immune responseGO:00695511.0CCR4, CTSG, CD274, IL18, FCGR3A
5positive regulation of macrophage chemotaxisGO:01075911.0C3AR1, CCL2, CCL5
6chemokine-mediated signaling pathwayGO:07009810.9CCL2, CCL5, CCR4
7cellular response to interferon-gammaGO:07134610.9IL18, CCL2, CCL5
8lipopolysaccharide-mediated signaling pathwayGO:03166310.9CCL5, CCL2, IL18
9cellular response to organic cyclic compoundGO:07140710.9IL18, CCL2, CCL5
10positive regulation of T cell proliferationGO:04210210.9VCAM1, CD274, CCL5
11MAPK cascadeGO:00016510.9CCL5, CCL2, IL18
12maintenance of gastrointestinal epitheliumGO:03027710.8RBP4, TLR9
13cellular calcium ion homeostasisGO:00687410.8CD40, CCL2, CCL5
14uterus developmentGO:06006510.8RBP4, GATA3
15response to ethanolGO:04547110.8CCL2, GATA3, RBP4
16negative regulation of fibrinolysisGO:05191810.7THBD, APOH
17positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.6TLR9, CCL2
18elevation of cytosolic calcium ion concentrationGO:00720410.6C3AR1, CXCR3, CCR4
19regulation of immune responseGO:05077610.6CD40, FCGR3A, VCAM1
20negative regulation of blood coagulationGO:03019510.5THBD, APOH
21macrophage chemotaxisGO:04824610.3CCL2, CCL5

Molecular functions related to Lupus Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.6FCGR3A, FCGR2A

Products for genes affiliated with Lupus Nephritis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lupus Nephritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet