MCID: LPS007
MIFTS: 53

Lupus Nephritis malady

Rare diseases category
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Summaries for Lupus Nephritis

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NIH Rare Diseases:42 Lupus nephritis is a kidney disorder that is a complication of systemic lupus erythematous (sle), commonly known as lupus. the symptoms of lupus nephritis include blood in the urine, a foamy appearance to the urine, high blood pressure, and swelling in any part of the body. this condition typically occurs in people aged 20 to 40 years. treatment may involve medications to suppress the immune system, dialysis, or a kidney transplant. visit our web page on lupus for more information and resources. last updated: 11/24/2010

MalaCards based summary: Lupus Nephritis is related to nephritis and systemic lupus erythematosus. An important gene associated with Lupus Nephritis is FCGR2A (Fc fragment of IgG, low affinity IIa, receptor (CD32)), and among its related pathways are African trypanosomiasis and A-beta Uptake and Degradation. The drug cyclophosphamide and the compounds dotap and natalizumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and monocytes, and related mouse phenotypes are cellular and renal/urinary system.

Wikipedia:65 Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE), a disease... more...

Aliases & Classifications for Lupus Nephritis

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Sources:
42NIH Rare Diseases, 46OMIM, 44Novoseek, 62UMLS
See all sources

Lupus Nephritis, Aliases & Descriptions:

Name: Lupus Nephritis 42 46 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Lupus Nephritis

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Diseases related to Lupus Nephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1nephritis31.7CCL2, CXCR3, FCGR3A, FCGR2A, CFB, IL18
2systemic lupus erythematosus31.6PDCD1, FCGR2A
3lupus erythematosus31.5APOH, DNASE1, TLR9, IL18
4proteinuria31.2CCL2, CD274, APOH
5proliferative glomerulonephritis31.0CXCR3, CCL2
6vasculitis30.9APOH, CCL2, CTSG
7glomerulonephritis30.8TLR9, CTSG, CCL2, FCGR2A
8thrombocytopenia30.6APOH, FCGR2A, FCGR3A
9connective tissue disease30.4TLR9, APOH, CCL2, CD40, DNASE1
10rheumatic disease30.3CXCR3, APOH, FCGR2A, IL18
11non-hodgkin lymphoma30.2CD40, FCGR2A, FCGR3A
12arthritis30.1CTSG, IL18, CCL2, CXCR3, FCGR3A, FCGR2A
13tuberculosis29.9IL18, CXCR3, TLR9, CTSG, DNASE1
14atherosclerosis29.5APOH, CD40, CXCR3, FCGR2A, IL18, CCL2
15rheumatoid arthritis27.9CTSG, FCGR2A, FCGR3A, CXCR3, CCL2, IL18
16kidney disease10.5
17periodontitis10.5FCGR2A
18endotheliitis10.4
19hypertension10.4
20primary immunodeficiency disease10.4CD40
21malaria10.4FCGR2A, TLR9
22membranoproliferative glomerulonephritis10.4
23pleural tuberculosis10.3CCL2, IL18
24relapsing-remitting multiple sclerosis10.3CXCR3, IL18
25periapical granuloma10.3CXCR3, CCL2
26nephrotic syndrome10.3
27purpura10.3
28bullous systemic lupus erythematosus10.3
29plasmodium falciparum malaria10.3FCGR2A, IL18
30hepatitis b10.2CFB, DNASE1
31pulmonary sarcoidosis10.2CCL2, IL18, CXCR3
32idiopathic pulmonary fibrosis10.2CXCR3, CCL2, IL18
33hairy cell leukemia10.2CXCR3, CD40
34atopy10.2TLR9, IL18, CXCR3
35sarcoidosis10.2IL18, CCL2, CXCR3
36focal segmental glomerulosclerosis10.2
37graft versus host disease10.2
38renal tubular acidosis10.2
39antiphospholipid syndrome10.2
40takayasu's arteritis10.2
41crescentic glomerulonephritis10.2
42renal fibrosis10.2
43thrombotic thrombocytopenic purpura10.2
44central nervous system lymphoma10.2
45glomerulosclerosis10.2
46hypothyroidism10.2
47intracranial hypertension10.2
48malignant hypertension10.2
49chronic graft versus host disease10.2
50virus associated hemophagocytic syndrome10.2

Graphical network of the top 20 diseases related to Lupus Nephritis:



Diseases related to lupus nephritis

Symptoms for Lupus Nephritis

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Drugs & Therapeutics for Lupus Nephritis

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Drug clinical trials:

Search ClinicalTrials for Lupus Nephritis

Search NIH Clinical Center for Lupus Nephritis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Lupus Nephritis

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Anatomical Context for Lupus Nephritis

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MalaCards organs/tissues related to Lupus Nephritis:

32
Kidney, Skin, Monocytes, T cells, B cells, Neutrophil, Endothelial, Whole blood, Heart, Liver, Testes

Animal Models for Lupus Nephritis or affiliated genes

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MGI Mouse Phenotypes related to Lupus Nephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.6CXCR3, CCL2, IL18, DNASE1, PDCD1, CD274
2MP:00053677.4TLR9, CFB, CXCR3, DNASE1, PDCD1, CD40
3MP:00053906.8CFB, FCGR2A, FCGR3A, CCL2, C3AR1, PDCD1
4MP:00053766.5TLR9, CFB, APOH, FCGR3A, CXCR3, CCL2
5MP:00107686.2CXCR3, FCGR2A, APOH, TLR9, CCL2, IL18
6MP:00053975.7CCL2, CXCR3, FCGR3A, FCGR2A, TLR9, IL18
7MP:00053875.2CTSG, TLR9, CFB, FCGR2A, FCGR3A, CXCR3

Publications for Lupus Nephritis

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Articles related to Lupus Nephritis:

(show top 50)    (show all 788)
idTitleAuthorsYear
1
Glomerular Autoimmune Multicomponents of Human Lupus Nephritis In Vivo (2): Planted Antigens. (25398787)
2014
2
Prednisone in lupus nephritis: how much is enough? (24189280)
2014
3
Proliferative lupus nephritis and leukocytoclastic vasculitis during treatment with etanercept. (25362726)
2014
4
Pathogenic autoantibodies from patients with lupus nephritis cause reduced tyrosine phosphorylation of podocyte proteins, including tubulin. (25396061)
2014
5
Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis with poor kidney function: a subgroup analysis of the Aspreva Lupus Management Study. (23375819)
2013
6
Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. (23896866)
2013
7
Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis. (23301082)
2013
8
Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming. (24300027)
2013
9
Low risk of renal flares and negative outcomes in women with lupus nephritis conceiving after switching from mycophenolate mofetil to azathioprine. (23382355)
2013
10
Kidney disease in lupus is not always 'lupus nephritis' (23448342)
2013
11
Current management of lupus nephritis. (24238689)
2013
12
Antiphospholipid syndrome nephropathy (APSN) in patients with lupus nephritis: a retrospective clinical and renal pathology study. (24232504)
2013
13
Predictive risk factors for failure to induction therapy of lupus nephritis in a cohort of Colombian patients. (24269070)
2013
14
Survival analysis and causes of mortality in patients with lupus nephritis. (22523116)
2012
15
The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis. (22900150)
2012
16
Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis. (22128082)
2012
17
Long-term outcome of lupus nephritis in Asian Indians. (22232126)
2012
18
Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis. (22348591)
2012
19
From the Large Scale Expression Analysis of Lupus Nephritis to Targeted Molecular Medicine. (23626922)
2012
20
Anti-C1q autoantibodies specific against the globular domain of the C1qB-chain from patient with lupus nephritis inhibit C1q binding to IgG and CRP. (22209113)
2012
21
A meta-analysis of randomized controlled trials comparing tacrolimus with intravenous cyclophosphamide in the induction treatment for lupus nephritis. (22820853)
2012
22
Major infections including tuberculosis as a primary risk factor for poor outcome of lupus nephritis in Asian Indians: comment on the article by Dhir et al. (22833501)
2012
23
Altered expression of TNFSF4 and TRAF2 mRNAs in peripheral blood mononuclear cells in patients with systemic lupus erythematosus: association with atherosclerotic symptoms and lupus nephritis. (22847298)
2012
24
Tumor necrosis factor-like weak inducer of apoptosis and its potential roles in lupus nephritis. (22297307)
2012
25
Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus. (21163672)
2011
26
The role of cytokines as biomarkers in systemic lupus erythematosus and lupus nephritis. (21372259)
2011
27
Predictive value of remission status after 6A months induction therapy in patients with proliferative lupus nephritis: a retrospective analysis. (21594768)
2011
28
Connective tissue diseases: Lupus nephritis-winning a few battles but not the war. (21691329)
2011
29
Complement factor H deficiency accelerates development of lupus nephritis. (21148254)
2011
30
The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans. (20523037)
2010
31
Intracranial hypertension: A rare presentation of lupus nephritis. (21559160)
2010
32
Increased urinary levels of the leukocyte adhesion molecules ICAM-1 and VCAM-1 in human lupus nephritis with advanced renal histological changes: preliminary findings. (20714774)
2010
33
Expression and significance of CD80/CD86 in renal tissue of lupus nephritis]. (20979791)
2010
34
Estimation of monocyte-chemoattractantprotein-1 (Mcp-1) level in patients with lupus nephritis. (20374368)
2009
35
An acquired inhibitor to the GPVI platelet collagen receptor in a patient with lupus nephritis. (19583823)
2009
36
Biomarkers of lupus nephritis determined by serial urine proteomics. (18596723)
2008
37
Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis. (17530720)
2007
38
Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis. (17239933)
2007
39
Ethnic, clinical and immunological factors in systemic lupus erythematosus and the development of lupus nephritis: results from a multi-ethnic New Zealand cohort. (17895308)
2007
40
Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis. (16461436)
2006
41
C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist. (16052609)
2005
42
The interplay of chemokines and dendritic cells in the pathogenesis of lupus nephritis. (16126984)
2005
43
Mesangial cell Fas ligand: upregulation in human lupus nephritis and NF-kappaB-mediated expression in cultured human mesangial cells. (15480896)
2004
44
Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis. (15119544)
2004
45
Antiphospholipid antibodies in patients with lupus nephritis. (14575283)
2003
46
Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. (12115187)
2002
47
Association of anticardiolipin antibodies with intraglomerular thrombi and renal dysfunction in lupus nephritis. (9709458)
1998
48
Highly cationic anti-DNA antibodies in patients with lupus nephritis analyzed by two-dimensional electrophoresis and immunoblotting. (9694304)
1998
49
Expression of intercellular adhesion molecule-1 and vascular adhesion molecule-1 in kidney of patients with lupus nephritis and membranoproliferative glomerulonephritis]. (7544695)
1995
50
Anti-cardiolipin antibody and renal microthrombi in lupus nephritis]. (1767341)
1991

Variations for Lupus Nephritis

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Expression for genes affiliated with Lupus Nephritis

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Expression patterns in normal tissues for genes affiliated with Lupus Nephritis

Search GEO for disease gene expression data for Lupus Nephritis.

Pathways for genes affiliated with Lupus Nephritis

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Pathways related to Lupus Nephritis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TLR9, IL18
29.4C3AR1, CCL2, CD40
3
Show member pathways
9.3CFB, FCGR2A, FCGR3A
4
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.2CD40, TLR9, CCL2
5
Show member pathways
9.2CD274, PDCD1
6
Show member pathways
9.1IL18, CCL2, TLR9, CXCR3
79.1FCGR2A, FCGR3A, TLR9, IL18
89.0CFB, FCGR3A, FCGR2A, C3AR1
9
Show member pathways
9.0CD40, IL18, CCL2, CXCR3
10
Show member pathways
9.0CD40, IL18, FCGR2A, FCGR3A
11
Show member pathways
9.0CXCR3, CCL2, C3AR1, CTSG
128.9CCL2, TLR9, IL18, CD40
13
Show member pathways
8.7CTSG, CD40, FCGR2A, FCGR3A
148.7CD40, CD274, PDCD1
15
Show member pathways
8.3CD274, PDCD1, FCGR3A, CD40

Compounds for genes affiliated with Lupus Nephritis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 50PharmGKB, 24HMDB
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Compounds related to Lupus Nephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1dotap4410.2TLR9, DNASE1
2natalizumab44 1110.9IL18, FCGR3A, FCGR2A
3groalpha449.8IL18, CCL2, CXCR3
4flagellin44 2810.8IL18, CXCR3, TLR9
5cetuximab44 50 1111.8TLR9, FCGR2A, FCGR3A
6infliximab44 50 1111.7APOH, FCGR2A, CXCR3, IL18
7tarc449.7IL18, CCL2, CXCR3
8abciximab44 1110.7FCGR2A, FCGR3A, CD40
9lipoteichoic acid449.6IL18, CCL2, APOH, TLR9
10ccl344 2810.5TLR9, IL18, CXCR3, CCL2
11lfa70344 1110.5IL18, CD40
12polyinosinic-polycytidylic acid449.5IL18, CD40, TLR9
13prednisolone44 28 1111.5CD40, APOH, FCGR2A, IL18
14mevalonate449.4CCL2, IL18, CD40
15ivig449.4FCGR2A, FCGR3A, CD40, APOH
16rituximab44 50 1111.4APOH, CD40, FCGR2A, FCGR3A
17il 10449.4CCL2, IL18, CD40, CXCR3
18etanercept44 50 1111.4IL18, FCGR2A, CXCR3, FCGR3A, APOH
19mannose449.4FCGR2A, FCGR3A, CD40, APOH
20fluvastatin44 50 28 1112.4CCL2, CD40, IL18
21pge1449.3APOH, CD40, IL18
22cyclophosphamide44 50 1111.3CD40, IL18, CCL2, APOH
23prostacyclin449.3CTSG, CCL2, FCGR2A, APOH
24methotrexate50 44 1111.2APOH, IL18, FCGR3A, CD40
25n acetylcysteine449.1IL18, DNASE1, CD40, CCL2
26ly294002449.1CD40, IL18, CCL2, CXCR3, FCGR2A
27polysaccharide449.1CTSG, DNASE1, IL18, CCL2, FCGR2A
28heparin44 28 24 1112.0DNASE1, CTSG, APOH, CXCR3, FCGR2A
29rantes449.0CD40, IL18, CCL2, CXCR3, TLR9
30pdtc449.0CD40, IL18, CCL2
31allergens448.9CXCR3, IL18, PDCD1, CD40
32fibrinogen448.8CTSG, APOH, CCL2, IL18, CD40
33fmlp448.7C3AR1, CXCR3, CCL2, FCGR3A, FCGR2A, CTSG
34thymidine44 249.7CTSG, DNASE1, IL18, CXCR3, CD40
35phosphatidylinositol448.7APOH, CXCR3, FCGR2A, FCGR3A, CCL2, CD40
36superoxide44 249.7APOH, CXCR3, CTSG, CD40, CCL2
37h2o2448.7FCGR2A, IL18, DNASE1, CD40, CTSG
38dexamethasone44 50 28 1111.6CXCR3, IL18, DNASE1, CD274, CCL2, CD40
39cholesterol44 28 24 1111.5CCL2, CD40, CXCR3, FCGR2A, APOH, FCGR3A
40oxygen44 249.5IL18, APOH, FCGR2A, CD40, FCGR3A, CXCR3
41arginine448.4IL18, APOH, FCGR2A, FCGR3A, CXCR3, CCL2
42histamine44 28 2410.3CCL2, IL18, CXCR3, C3AR1, FCGR2A, CD40
43creatinine448.3CD40, IL18, DNASE1, CTSG, APOH, CXCR3
44endotoxin448.2APOH, TLR9, CXCR3, CCL2, IL18, CD40
45lipid448.1CD40, CCL2, IL18, APOH, FCGR2A, CTSG
46glucose448.1CD40, CTSG, IL18, APOH, CFB, CCL2
47nitric oxide44 24 119.7IL18, CD274, CCL2, CD40, CXCR3, APOH
48tyrosine447.6CD40, C3AR1, CXCR3, FCGR2A, TLR9, FCGR3A
49calcium44 50 24 1110.3CTSG, DNASE1, APOH, FCGR2A, FCGR3A, CXCR3
50serine447.1CTSG, CFB, FCGR2A, CXCR3, CCL2, IL18

GO Terms for genes affiliated with Lupus Nephritis

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Cellular components related to Lupus Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.4CTSG, CD40, IL18, CCL2, APOH
2external side of plasma membraneGO:0098978.0FCGR3A, CXCR3, PDCD1, CD274, CD40
3extracellular regionGO:0055767.3DNASE1, IL18, CCL2, FCGR3A, CFB, TLR9
4plasma membraneGO:0058865.9PDCD1, C3AR1, CXCR3, FCGR3A, FCGR2A, CFB

Biological processes related to Lupus Nephritis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage chemotaxisGO:01075910.1CCL2, C3AR1
2positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.0CCL2, TLR9
3negative regulation of endothelial cell proliferationGO:00193710.0APOH, CXCR3
4positive regulation of NF-kappaB import into nucleusGO:0423469.9TLR9, IL18
5negative regulation of angiogenesisGO:0165259.8CXCR3, APOH, CCL2
6lipopolysaccharide-mediated signaling pathwayGO:0316639.8IL18, CCL2
7cellular response to organic cyclic compoundGO:0714079.8IL18, CCL2
8chemotaxisGO:0069359.8CXCR3, CCL2, C3AR1
9positive regulation of interleukin-12 productionGO:0327359.7CD40, TLR9
10cell surface receptor signaling pathwayGO:0071669.6CCL2, CD274, CXCR3
11angiogenesisGO:0015259.4IL18, CXCR3, CCL2
12immune responseGO:0069558.9CTSG, IL18, FCGR3A, CD274
13inflammatory responseGO:0069548.6IL18, CD40, CCL2, CXCR3, TLR9, C3AR1
14innate immune responseGO:0450878.6FCGR3A, FCGR2A, CFB, TLR9

Molecular functions related to Lupus Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:0198649.5FCGR3A, FCGR2A
2heparin bindingGO:0082019.2CTSG, CCL2, APOH

Products for genes affiliated with Lupus Nephritis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Lupus Nephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet