MCID: LTM002
MIFTS: 30

Luteoma malady

Category: Reproductive diseases

Aliases & Classifications for Luteoma

About this section

Aliases & Descriptions for Luteoma:

Name: Luteoma 11 50 13 68
Leuteoma of Pregnancy 11
 
Luteoma of Pregnancy 11

Classifications:



External Ids:

Disease Ontology11 DOID:7880
NCIt45 C40445

Summaries for Luteoma

About this section
Wikipedia:71 A luteoma is a tumor that occurs in the ovaries during pregnancy. It is associated with an increase of... more...

MalaCards based summary: Luteoma, also known as leuteoma of pregnancy, is related to dyt1 early-onset isolated dystonia and epithelial predominant pulmonary blastoma. An important gene associated with Luteoma is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways are Angiogenesis (CST) and Central carbon metabolism in cancer. Affiliated tissues include ovary and uterus, and related mouse phenotype reproductive system.

Related Diseases for Luteoma

About this section

Diseases related to Luteoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1dyt1 early-onset isolated dystonia10.2CYP21A2, FGFR2
2epithelial predominant pulmonary blastoma10.2CYP21A2, STAR
3familial porphyria cutanea tarda10.1FGFR2, FGFR3
4clear cell acanthoma10.1CYP21A2, STAR
5hartsfield syndrome10.1FGFR2, FGFR3
6microphthalmia, syndromic 910.1CYP21A2, STAR
7pointer syndrome10.1FGFR2, FGFR3
8antley-bixler syndrome without genital anomalies or disordered steroidogenesis10.1FGFR2, FGFR3
9osteoglophonic dysplasia10.1FGFR2, FGFR3
10jackson-weiss syndrome10.1CYP21A2, STAR
11aica-ribosiduria due to atic deficiency10.1FGFR2, FGFR3
12crouzon syndrome with acanthosis nigricans10.1FGFR2, FGFR3
13muenke syndrome10.1FGFR2, FGFR3
14deafness, autosomal recessive 6110.1CYP21A2, FGFR3
15lingual-facial-buccal dyskinesia10.1FGFR2, FGFR3
16sp7-related osteogenesis imperfecta10.1FGFR2, FGFR3
17leg dermatosis10.1FGFR2, FGFR3
18scaphocephaly, maxillary retrusion, and mental retardation10.1FGFR2, FGFR3
19apert syndrome10.1FGFR2, FGFR3
20cervical cancer, somatic10.1FGFR2, FGFR3
21second-degree atrioventricular block10.1CYP21A2, STAR
22thanatophoric dysplasia, type i10.1FGFR2, FGFR3
23saddan10.1FGFR2, FGFR3
24loeffler endocarditis10.1CYP21A2, STAR
25hypermobility syndrome10.0CYP21A2, STAR
26borderline personality disorder10.0CYP19A1, CYP21A2
27leukoencephalopathy with ataxia10.0CYP19A1, CYP21A2
28robinow-sorauf syndrome10.0FGFR2, FGFR3
29sphingolipidosis10.0CYP19A1, CYP21A2
30bone structure disease10.0FGFR2, FGFR3
31hypoparathyroidism10.0FGFR2, FGFR3
32autosomal genetic disease10.0FGFR2, FGFR3
33pelvic muscle wasting10.0CYP19A1, CYP21A2
34bardet-biedl syndrome 110.0CGA, CYP19A1
35progesterone-receptor negative breast cancer9.9CYP19A1, FGFR2
36atrophy of testis9.9FGFR2, FGFR3
37congenital articular rigidity9.9CGA, CYP19A1
38hypospadias 1, x-linked9.9CGA, CYP19A1
39capillary disease9.9CGA, CYP19A1
40epidural spinal canal meningioma9.9CGA, CYP19A1
41spinocerebellar ataxia 259.9CGA, CYP19A1
42antley-bixler syndrome9.9
43bent bone dysplasia syndrome9.9CYP19A1, CYP21A2, FGFR2
44epidemic typhus9.9CYP19A1, CYP21A2, FGFR2
45hypogonadotropic hypogonadism 2 with or without anosmia9.9FGFR2, FGFR3
46liver sarcoma9.8CYP19A1, CYP21A2, STAR
47glioma susceptibility 19.8CYP19A1, CYP21A2, STAR
48adrenal cortical carcinoma9.7
49congenital adrenal hyperplasia9.7
50ovarian disease9.7

Graphical network of the top 20 diseases related to Luteoma:



Diseases related to luteoma

Symptoms & Phenotypes for Luteoma

About this section

MGI Mouse Phenotypes related to Luteoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.5CGA, CYP19A1, FGFR2, FGFR3, STAR

Drugs & Therapeutics for Luteoma

About this section

Interventional clinical trials:

Genetic Tests for Luteoma

About this section

Anatomical Context for Luteoma

About this section

MalaCards organs/tissues related to Luteoma:

36
Ovary, Uterus

Publications for Luteoma

About this section

Articles related to Luteoma:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Luteoma of Pregnancy. (28081022)
2017
2
A Metastatic Ovarian Tumor Mimicking Pregnancy Luteoma Found during Puerperium. (26726013)
2016
3
Pregnancy luteoma: A rare case report. (27857898)
2016
4
A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling. (27355981)
2016
5
Luteoma of Pregnancy Presenting with Severe Maternal Virilisation: A Case Report. (27660728)
2016
6
Pregnancy luteoma followed with massive ascites and elevated CA125 after ovulation induction therapy: a case report and review of literatures. (25785161)
2015
7
Bilateral pregnancy luteoma: a case report. (25337317)
2014
8
Pregnancy Luteoma: A Study of 20 Cases on the Occasion of the 50th Anniversary of its Description by Dr William H. Sternberg, With an Emphasis on the Common Presence of Follicle-like Spaces and Their Diagnostic Implications. (24335664)
2014
9
Stromal luteoma of the ovary: A rare ovarian pathology. (25140903)
2014
10
Luteoma of Pregnancy Associated with Near Complete Virilization of Genetically Female Twins. (24126228)
2013
11
Stromal luteoma and nodular hyperthecosis of the bilateral ovaries associated with atypical endometrial hyperplasia of the uterus. (19883437)
2009
12
Unilateral luteoma of pregnancy mimicking a malignant ovarian mass on magnetic resonance and ultrasound. (19243065)
2009
13
Luteoma-induced fetal virilization. (20149054)
2009
14
Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development. (19110243)
2009
15
Maternal virilization due to luteoma associated with delayed lactation. (18635167)
2008
16
Pregnancy luteoma presenting as ovarian torsion with rupture and intra-abdominal bleeding. (18362993)
2008
17
Ovarian stromal luteoma in a patient with endometrial carcinoma. (18412799)
2008
18
Stromal luteoma: report of a rare case. (17883070)
2007
19
Krukenberg tumor mimicking pregnancy luteoma. (17852427)
2007
20
Maternal luteoma of pregnancy presenting with virilization of the female infant. (17915067)
2007
21
Luteoma of pregnancy. (17000514)
2006
22
MR imaging of pregnancy luteoma: a case report and correlation with the clinical features. (15782020)
2005
23
Granulosa theca cell tumor with luteoma in the ovary of a bonnet monkey (Macaca radiata). (16053501)
2005
24
Magnetic resonance imaging of pregnancy luteoma. (12703004)
2003
25
Prenatal diagnosis of female pseudohermaphroditism associated with bilateral luteoma of pregnancy: case report. (11870143)
2002
26
Congenital adrenal hyperplasia associated with maternal pregnancy luteoma and the Antley-Bixler syndrome. (10726707)
2000
27
Features of Antley-Bixler syndrome in an infant born to a mother with pregnancy luteoma. (10664233)
2000
28
Luteoma of pregnancy: sonographic findings in two cases. (11127014)
2000
29
Pregnancy luteoma with granulosa cell proliferation: an unusual hyperplastic lesion arising in pregnancy and mimicking an ovarian neoplasia. (10631723)
1999
30
Luteoma of pregnancy presenting with massive ascites and markedly elevated CA 125. (10546765)
1999
31
GnRH receptors and GnRH endocrine effects on luteoma cells. (9225131)
1997
32
Ovarian steroid cell tumor resembling luteoma associated with hyperadrenocorticism (Cushing's disease) in a dog. (9150550)
1997
33
A gonadotrophin dependent stromal luteoma: a rare cause of post-menopausal virilization. (8548951)
1995
34
Luteoma of pregnancy: masculinisation of a female fetus prevented by placental aromatisation. (1335753)
1992
35
Luteoma of pregnancy. (2157147)
1990
36
Malignant luteoma in a sow. (2551110)
1989
37
Stromal luteoma of the ovary: a clinicopathological analysis of 25 cases. (2826353)
1987
38
Luteoma of pregnancy. (6330914)
1984
39
High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma. (6094939)
1984
40
In vivo steroid studies in luteoma of pregnancy. (6283444)
1982
41
A case of virilizing luteoma. (6244616)
1980
42
Differential maternal-fetal response to androgenizing luteoma or hyperreactio luteinalis. (205819)
1978
43
Incidental pregnancy luteoma associated with ectopic tubo-ovarian pregnancy: evidence in favor of origin from theca interna of an atretic follicle. (233743)
1978
44
Virilization of mother and fetus associated with luteoma of pregnancy: a case report with endocrinologic studies. (197851)
1977
45
Properties of human gonadotrophins eluted from human corpus luteum and mouse luteoma LH-HCG receptors. (188284)
1977
46
Luteoma of pregnancy: ultrastructural features. (177351)
1976
47
Luteoma of pregnancy: report of a case and review of the literature. (163309)
1975
48
Letter: Luteoma of pregnancy. (170823)
1975
49
Luteoma of pregnancy: case report. (163588)
1975
50
Remission of acanthosis nigricans associated with polycystic ovarian disease and a stromal luteoma. (4360917)
1974

Variations for Luteoma

About this section

Expression for genes affiliated with Luteoma

About this section
Search GEO for disease gene expression data for Luteoma.

GO Terms for genes affiliated with Luteoma

About this section

Biological processes related to Luteoma according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1bone mineralizationGO:003028210.2FGFR2, FGFR3
2bone morphogenesisGO:006034910.2FGFR2, FGFR3
3endochondral bone growthGO:000341610.2FGFR2, FGFR3
4cellular response to transforming growth factor beta stimulusGO:007156010.2FGFR2, STAR
5fibroblast growth factor receptor signaling pathwayGO:000854310.2FGFR2, FGFR3
6phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.2FGFR2, FGFR3
7positive regulation of MAPK cascadeGO:004341010.1FGFR2, FGFR3
8positive regulation of phospholipase activityGO:001051810.1FGFR2, FGFR3
9regulation of phosphatidylinositol 3-kinase signalingGO:001406610.0FGFR2, FGFR3
10estrogen biosynthetic processGO:00067039.8CYP19A1, STAR
11cell-cell signalingGO:00072679.6CGA, FGFR2, FGFR3
12positive regulation of cell proliferationGO:00082849.5CGA, FGFR2, FGFR3
13sterol metabolic processGO:00161259.4CYP19A1, CYP21A2
14testosterone biosynthetic processGO:00613709.1CYP19A1, STAR
15steroid biosynthetic processGO:00066949.1CYP19A1, CYP21A2, STAR

Molecular functions related to Luteoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
11-phosphatidylinositol-3-kinase activityGO:001630310.1FGFR2, FGFR3
2fibroblast growth factor bindingGO:001713410.1FGFR2, FGFR3
3fibroblast growth factor-activated receptor activityGO:000500710.1FGFR2, FGFR3
4phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:004693410.0FGFR2, FGFR3
5oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenGO:00167059.8CYP19A1, CYP21A2
6steroid hydroxylase activityGO:00083959.7CYP19A1, CYP21A2
7transmembrane receptor protein tyrosine kinase activityGO:00047149.5FGFR2, FGFR3

Sources for Luteoma

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet