Aliases & Classifications for Luteoma

MalaCards integrated aliases for Luteoma:

Name: Luteoma 12 51 14 69
Leuteoma of Pregnancy 12
Luteoma of Pregnancy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7880
NCIt 46 C40445

Summaries for Luteoma

MalaCards based summary : Luteoma, also known as leuteoma of pregnancy, is related to acanthosis nigricans and lipoid congenital adrenal hyperplasia. An important gene associated with Luteoma is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Corticotropin-releasing hormone signaling pathway. Affiliated tissues include ovary and uterus, and related phenotype is reproductive system.

Wikipedia : 72 A luteoma is a tumor that occurs in the ovaries during pregnancy. It is associated with an increase of... more...

Related Diseases for Luteoma

Diseases related to Luteoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 acanthosis nigricans 30.0 FGFR2 FGFR3
2 lipoid congenital adrenal hyperplasia 29.9 CYP21A2 STAR
3 sex differentiation disease 29.7 CYP19A1 CYP21A2
4 antley-bixler syndrome 29.5 CYP19A1 CYP21A2 FGFR2
5 ovarian disease 29.0 CGA CYP19A1
6 testicular leydig cell tumor 10.2 CYP21A2 STAR
7 steroid inherited metabolic disorder 10.2 CYP21A2 STAR
8 plagiocephaly 10.2 FGFR2 FGFR3
9 osteoglophonic dysplasia 10.2 FGFR2 FGFR3
10 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 10.2 CYP21A2 STAR
11 beare-stevenson cutis gyrata syndrome 10.2 FGFR2 FGFR3
12 hypoadrenocorticism, familial 10.2 CYP21A2 STAR
13 jackson-weiss syndrome 10.2 FGFR2 FGFR3
14 thanatophoric dysplasia, type i 10.2 FGFR2 FGFR3
15 hypertropia 10.2 FGFR2 FGFR3
16 osteogenesis imperfecta, type ii 10.2 CYP21A2 FGFR3
17 hypochondroplasia 10.2 FGFR2 FGFR3
18 apert syndrome 10.1 FGFR2 FGFR3
19 crouzon syndrome 10.1 FGFR2 FGFR3
20 lacrimoauriculodentodigital syndrome 10.1 FGFR2 FGFR3
21 achondroplasia 10.1 FGFR2 FGFR3
22 muenke syndrome 10.1 FGFR2 FGFR3
23 bone development disease 10.1 FGFR2 FGFR3
24 adrenal carcinoma 10.1 CYP21A2 STAR
25 chromosome 2q35 duplication syndrome 10.1 FGFR2 FGFR3
26 saethre-chotzen syndrome 10.0 FGFR2 FGFR3
27 porokeratosis 10.0 FGFR2 FGFR3
28 pfeiffer syndrome 10.0 FGFR2 FGFR3
29 synostosis 10.0 FGFR2 FGFR3
30 transsexualism 10.0 CYP19A1 CYP21A2
31 alopecia, androgenetic, 1 10.0 CYP19A1 CYP21A2
32 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 10.0
33 precocious puberty 10.0 CYP19A1 CYP21A2
34 autosomal dominant disease 9.9 FGFR2 FGFR3
35 hyperandrogenism 9.9 CYP19A1 CYP21A2
36 estrogen-receptor positive breast cancer 9.9 CYP19A1 FGFR2
37 oocyte maturation defect 1 9.8 CGA CYP19A1
38 ectopic pregnancy 9.8
39 endometriosis 9.8
40 pseudohermaphroditism 9.8
41 complete androgen insensitivity syndrome 9.8 CGA CYP19A1
42 strabismus 9.8 FGFR2 FGFR3
43 anovulation 9.8 CGA CYP19A1
44 gynecomastia 9.8 CGA CYP19A1
45 ovarian hyperstimulation syndrome 9.7 CGA CYP19A1
46 premature ovarian failure 1 9.7 CYP19A1 STAR
47 leydig cell tumor 9.6 CYP19A1 CYP21A2 STAR
48 adrenocortical carcinoma, hereditary 9.6 CYP19A1 CYP21A2 STAR
49 polycystic ovary syndrome 9.6 CYP19A1 CYP21A2 STAR
50 cryptorchidism, unilateral or bilateral 9.6 CGA CYP19A1

Graphical network of the top 20 diseases related to Luteoma:



Diseases related to Luteoma

Symptoms & Phenotypes for Luteoma

MGI Mouse Phenotypes related to Luteoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.02 CGA CYP19A1 FGFR2 FGFR3 STAR

Drugs & Therapeutics for Luteoma

Search Clinical Trials , NIH Clinical Center for Luteoma

Genetic Tests for Luteoma

Anatomical Context for Luteoma

MalaCards organs/tissues related to Luteoma:

38
Ovary, Uterus

Publications for Luteoma

Articles related to Luteoma:

(show top 50) (show all 80)
# Title Authors Year
1
Pregnancy Luteoma in Ectopic Pregnancy: A Case Report. ( 29062798 )
2017
2
Unilateral luteoma of the ovary in a pregnant Risso's dolphin (Grampus griseus). ( 28845023 )
2017
3
Sclerosing Stromal Tumor Mimicking a Pregnancy Luteoma: Case Report of a Diagnostically Challenging Entity Further Complicated by the Presence of Metastatic Signet Ring Cell Carcinoma From the Stomach. ( 28633616 )
2017
4
Luteoma of Pregnancy. ( 28081022 )
2017
5
A puzzling ovarian tumour: pregnancy luteoma with diffuse endometriosis. ( 28195267 )
2016
6
A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling. ( 27355981 )
2016
7
Luteoma of Pregnancy Presenting with Severe Maternal Virilisation: A Case Report. ( 27660728 )
2016
8
Pregnancy luteoma: A rare case report. ( 27857898 )
2016
9
A Metastatic Ovarian Tumor Mimicking Pregnancy Luteoma Found during Puerperium. ( 26726013 )
2016
10
Pregnancy luteoma followed with massive ascites and elevated CA125 after ovulation induction therapy: a case report and review of literatures. ( 25785161 )
2015
11
Bilateral pregnancy luteoma: a case report. ( 25337317 )
2014
12
Stromal luteoma of the ovary: A rare ovarian pathology. ( 25140903 )
2014
13
Pregnancy Luteoma: A Study of 20 Cases on the Occasion of the 50th Anniversary of its Description by Dr William H. Sternberg, With an Emphasis on the Common Presence of Follicle-like Spaces and Their Diagnostic Implications. ( 24335664 )
2014
14
Luteoma of Pregnancy Associated with Near Complete Virilization of Genetically Female Twins. ( 24126228 )
2013
15
Unilateral luteoma of pregnancy mimicking a malignant ovarian mass on magnetic resonance and ultrasound. ( 19243065 )
2009
16
Luteoma-induced fetal virilization. ( 20149054 )
2009
17
Stromal luteoma and nodular hyperthecosis of the bilateral ovaries associated with atypical endometrial hyperplasia of the uterus. ( 19883437 )
2009
18
Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development. ( 19110243 )
2009
19
Ovarian stromal luteoma in a patient with endometrial carcinoma. ( 18412799 )
2008
20
Pregnancy luteoma presenting as ovarian torsion with rupture and intra-abdominal bleeding. ( 18362993 )
2008
21
Maternal virilization due to luteoma associated with delayed lactation. ( 18635167 )
2008
22
Stromal luteoma: report of a rare case. ( 17883070 )
2007
23
Krukenberg tumor mimicking pregnancy luteoma. ( 17852427 )
2007
24
Maternal luteoma of pregnancy presenting with virilization of the female infant. ( 17915067 )
2007
25
Luteoma of pregnancy. ( 17000514 )
2006
26
MR imaging of pregnancy luteoma: a case report and correlation with the clinical features. ( 15782020 )
2005
27
Granulosa theca cell tumor with luteoma in the ovary of a bonnet monkey (Macaca radiata). ( 16053501 )
2005
28
Magnetic resonance imaging of pregnancy luteoma. ( 12703004 )
2003
29
Prenatal diagnosis of female pseudohermaphroditism associated with bilateral luteoma of pregnancy: case report. ( 11870143 )
2002
30
Luteoma of pregnancy: sonographic findings in two cases. ( 11127014 )
2000
31
Features of Antley-Bixler syndrome in an infant born to a mother with pregnancy luteoma. ( 10664233 )
2000
32
Congenital adrenal hyperplasia associated with maternal pregnancy luteoma and the Antley-Bixler syndrome. ( 10726707 )
2000
33
Pregnancy luteoma with granulosa cell proliferation: an unusual hyperplastic lesion arising in pregnancy and mimicking an ovarian neoplasia. ( 10631723 )
1999
34
Luteoma of pregnancy presenting with massive ascites and markedly elevated CA 125. ( 10546765 )
1999
35
Ovarian steroid cell tumor resembling luteoma associated with hyperadrenocorticism (Cushing's disease) in a dog. ( 9150550 )
1997
36
GnRH receptors and GnRH endocrine effects on luteoma cells. ( 9225131 )
1997
37
A gonadotrophin dependent stromal luteoma: a rare cause of post-menopausal virilization. ( 8548951 )
1995
38
Luteoma of pregnancy: masculinisation of a female fetus prevented by placental aromatisation. ( 1335753 )
1992
39
Luteoma of pregnancy. ( 2157147 )
1990
40
Malignant luteoma in a sow. ( 2551110 )
1989
41
Stromal luteoma of the ovary: a clinicopathological analysis of 25 cases. ( 2826353 )
1987
42
High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma. ( 6094939 )
1984
43
Luteoma of pregnancy. ( 6330914 )
1984
44
In vivo steroid studies in luteoma of pregnancy. ( 6283444 )
1982
45
A case of virilizing luteoma. ( 6244616 )
1980
46
Incidental pregnancy luteoma associated with ectopic tubo-ovarian pregnancy: evidence in favor of origin from theca interna of an atretic follicle. ( 233743 )
1978
47
Differential maternal-fetal response to androgenizing luteoma or hyperreactio luteinalis. ( 205819 )
1978
48
Virilization of mother and fetus associated with luteoma of pregnancy: a case report with endocrinologic studies. ( 197851 )
1977
49
Properties of human gonadotrophins eluted from human corpus luteum and mouse luteoma LH-HCG receptors. ( 188284 )
1977
50
Luteoma of pregnancy: ultrastructural features. ( 177351 )
1976

Variations for Luteoma

Expression for Luteoma

Search GEO for disease gene expression data for Luteoma.

Pathways for Luteoma

GO Terms for Luteoma

Biological processes related to Luteoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 CGA FGFR2 FGFR3
2 cell-cell signaling GO:0007267 9.65 CGA FGFR2 FGFR3
3 fibroblast growth factor receptor signaling pathway GO:0008543 9.52 FGFR2 FGFR3
4 cellular response to transforming growth factor beta stimulus GO:0071560 9.51 FGFR2 STAR
5 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.49 FGFR2 FGFR3
6 bone mineralization GO:0030282 9.46 FGFR2 FGFR3
7 cellular response to fibroblast growth factor stimulus GO:0044344 9.43 FGFR2 STAR
8 bone morphogenesis GO:0060349 9.4 FGFR2 FGFR3
9 sterol metabolic process GO:0016125 9.37 CYP19A1 CYP21A2
10 estrogen biosynthetic process GO:0006703 9.32 CYP19A1 STAR
11 positive regulation of phospholipase activity GO:0010518 9.26 FGFR2 FGFR3
12 endochondral bone growth GO:0003416 9.16 FGFR2 FGFR3
13 testosterone biosynthetic process GO:0061370 8.96 CYP19A1 STAR
14 steroid biosynthetic process GO:0006694 8.8 CYP19A1 CYP21A2 STAR

Molecular functions related to Luteoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.4 CYP19A1 CYP21A2
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.37 FGFR2 FGFR3
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.32 FGFR2 FGFR3
4 1-phosphatidylinositol-3-kinase activity GO:0016303 9.26 FGFR2 FGFR3
5 steroid hydroxylase activity GO:0008395 9.16 CYP19A1 CYP21A2
6 fibroblast growth factor binding GO:0017134 8.96 FGFR2 FGFR3
7 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR2 FGFR3

Sources for Luteoma

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