MCID: LTM002
MIFTS: 32

Luteoma malady

Reproductive diseases category

Summaries for Luteoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 A luteoma is a tumor that occurs in the ovaries during pregnancy. It is associated with an increases of... more...

MalaCards: Luteoma, also known as leuteoma of pregnancy, is related to congenital adrenal hyperplasia and antley-bixler syndrome. An important gene associated with Luteoma is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways is Metabolism of steroid hormones and vitamin D. The compounds deoxyribonucleic acid and biotin have been mentioned in the context of this disorder. Affiliated tissues include ovary and uterus.

Aliases & Classifications for Luteoma

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

luteoma 9 11 46 63
leuteoma of pregnancy 9
luteoma of pregnancy 9


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Disease Ontology9 DOID:7880
NCIt41 C40445

Related Diseases for Luteoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Luteoma:



Diseases related to luteoma

Symptoms for Luteoma

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Drugs & Therapeutics for Luteoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Luteoma

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Anatomical Context for Luteoma

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34MalaCards
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MalaCards organs/tissues related to Luteoma:

34
Ovary, Uterus

Animal Models for Luteoma or affiliated genes

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Publications for Luteoma

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53PubMed
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Articles related to Luteoma:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Pregnancy Luteoma: A Study of 20 Cases on the Occasion of the 50th Anniversary of its Description by Dr William H. Sternberg, With an Emphasis on the Common Presence of Follicle-like Spaces and Their Diagnostic Implications. (24335664)
2014
2
Unilateral luteoma of pregnancy mimicking a malignant ovarian mass on magnetic resonance and ultrasound. (19243065)
2009
3
Luteoma-induced fetal virilization. (20149054)
2009
4
Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development. (19110243)
2009
5
Maternal virilization due to luteoma associated with delayed lactation. (18635167)
2008
6
Pregnancy luteoma presenting as ovarian torsion with rupture and intra-abdominal bleeding. (18362993)
2008
7
Ovarian stromal luteoma in a patient with endometrial carcinoma. (18412799)
2008
8
Stromal luteoma: report of a rare case. (17883070)
2007
9
Krukenberg tumor mimicking pregnancy luteoma. (17852427)
2007
10
Maternal luteoma of pregnancy presenting with virilization of the female infant. (17915067)
2007
11
Granulosa theca cell tumor with luteoma in the ovary of a bonnet monkey (Macaca radiata). (16053501)
2005
12
MR imaging of pregnancy luteoma: a case report and correlation with the clinical features. (15782020)
2005
13
Magnetic resonance imaging of pregnancy luteoma. (12703004)
2003
14
Prenatal diagnosis of female pseudohermaphroditism associated with bilateral luteoma of pregnancy: case report. (11870143)
2002
15
Features of Antley-Bixler syndrome in an infant born to a mother with pregnancy luteoma. (10664233)
2000
16
Congenital adrenal hyperplasia associated with maternal pregnancy luteoma and the Antley-Bixler syndrome. (10726707)
2000
17
Luteoma of pregnancy presenting with massive ascites and markedly elevated CA 125. (10546765)
1999
18
Pregnancy luteoma with granulosa cell proliferation: an unusual hyperplastic lesion arising in pregnancy and mimicking an ovarian neoplasia. (10631723)
1999
19
GnRH receptors and GnRH endocrine effects on luteoma cells. (9225131)
1997
20
Luteoma of pregnancy: masculinisation of a female fetus prevented by placental aromatisation. (1335753)
1992
21
High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma. (6094939)
1984
22
Luteoma of pregnancy. (6330914)
1984
23
In vivo steroid studies in luteoma of pregnancy. (6283444)
1982
24
A case of virilizing luteoma. (6244616)
1980
25
Incidental pregnancy luteoma associated with ectopic tubo-ovarian pregnancy: evidence in favor of origin from theca interna of an atretic follicle. (233743)
1978
26
Differential maternal-fetal response to androgenizing luteoma or hyperreactio luteinalis. (205819)
1978
27
Properties of human gonadotrophins eluted from human corpus luteum and mouse luteoma LH-HCG receptors. (188284)
1977
28
Virilization of mother and fetus associated with luteoma of pregnancy: a case report with endocrinologic studies. (197851)
1977
29
Luteoma of pregnancy: ultrastructural features. (177351)
1976
30
Letter: Luteoma of pregnancy. (170823)
1975
31
Luteoma of pregnancy: report of a case and review of the literature. (163309)
1975
32
Remission of acanthosis nigricans associated with polycystic ovarian disease and a stromal luteoma. (4360917)
1974
33
Virilizing luteoma of pregnancy. Report of a case with measurements of testosterone and testosterone binding in plasma. (4346682)
1973
34
Gonadotropin receptor of a mouse luteoma: interactions with luteinizing hormone (LH) and its and subunits. (4351508)
1973
35
Luteoma in pregnancy. (4375468)
1973
36
Luteoma of pregnancy. (4335590)
1972
37
Transplantable luteoma of the mouse. An ultrastructural and biochemical study. (4338338)
1972
38
Luteoma of pregnancy. (4319381)
1970
39
Luteoma of pregnancy: recurrent or persistent? (5366428)
1969
40
Luteoma of pregnancy: steroidogenic and morphologic considerations. (4307340)
1969
41
Luteoma of pregnancy. Report of a case. (4317074)
1968
42
Ambiguous genitals in a female infant associated with luteoma of pregnancy. Report of a case. (4298215)
1968
43
Steroid content and synthesis in a virilizing luteoma. (4290318)
1967
44
Luteoma of pregnancy. A pseudotumor. (4193143)
1967
45
STROMAL LUTEOMA OF THE OVARY. A DISTINCTIVE TYPE OF LIPOID-CELL TUMOR. (14176990)
1964
46
PSEUDOPRECOCITY IN AN INFANT DUE TO A LUTEOMA OF THE OVARY. (14065997)
1963
47
Neutral steroids in the urine of a patient with a luteoma of the ovary. (13069593)
1953
48
Luteoma of the ovary. (14918776)
1952
49
Luteoma of the ovary; a case showing decidualization of the endometrium and a high pregnanediol excretion rate. (20984666)
1946
50
Transplantability of induced granulosa cell tumors and of luteoma in mice; secondary effects of these growths. (21024146)
1946

Variations for Luteoma

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Expression for genes affiliated with Luteoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Luteoma

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Pathways for genes affiliated with Luteoma

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51PathCards, 56Reactome, 39NCBI BioSystems Database
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Pathways related to Luteoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0CGA, CYP21A2

Compounds for genes affiliated with Luteoma

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46Novoseek, 25HMDB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB
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Compounds related to Luteoma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1deoxyribonucleic acid469.6SRY, CYP21A2
2biotin46 25 1211.6SRY, CYP21A2
3agarose469.6CYP21A2, SRY
4nafarelin46 62 30 1212.4CGA, CYP21A2
517-hydroxypregnenolone469.4CGA, CYP21A2
611 deoxycortisol469.4CYP21A2, CGA
7leuprolide acetate469.4CGA, CYP21A2
8clomiphene citrate469.4CYP21A2, CGA
917-hydroxyprogesterone46 2510.4CGA, CYP21A2
103beta-hydroxysteroid469.4CGA, CYP21A2
1117beta-hydroxysteroid469.4CGA, CYP21A2
12dehydroepiandrosterone sulfate469.3CGA, CYP21A2
13phenytoin46 52 30 1212.3CYP21A2, CGA
14androstenedione46 2510.3CGA, CYP21A2
15thyroxine46 2510.3CGA, CYP21A2
16carbon469.3CGA, CYP21A2
17leucine469.2SRY, CYP21A2
18gnrh469.2CYP21A2, CGA
19epinephrine46 25 1211.2CGA, CYP21A2
20ribonucleic acid469.1CGA, CYP21A2
21norepinephrine46 25 1211.1CGA, CYP21A2
22forskolin46 52 1211.0CYP21A2, CGA
23progesterone46 30 62 25 1213.0CGA, CYP21A2
24dihydrotestosterone46 30 25 1211.9CGA, SRY, CYP21A2
25estradiol46 25 1210.9CGA, SRY, CYP21A2
26testosterone46 62 25 1211.9CGA, SRY, CYP21A2
27steroid468.8CYP21A2, SRY, CGA
28cycloheximide468.7CGA, CYP21A2
29serine468.7CGA, SRY, CYP21A2

GO Terms for genes affiliated with Luteoma

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Products for genes affiliated with Luteoma

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  • Antibodies
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  • Lysates
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Sources for Luteoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet