MCID: LTM002
MIFTS: 28

Luteoma malady

Summaries for Luteoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 A luteoma is a tumor that occurs in the ovaries during pregnancy. It is associated with an increases of... more...

MalaCards: Luteoma, also known as leuteoma of pregnancy, is related to congenital adrenal hyperplasia and antley-bixler syndrome. An important gene associated with Luteoma is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2). The compounds nafarelin and 17-hydroxypregnenolone have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and uterus corpus.

Aliases & Classifications for Luteoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt
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Aliases & Descriptions:

luteoma 8 10 45 61
leuteoma of pregnancy 8
luteoma of pregnancy 8


External Ids:

Disease Ontology8 DOID:7880
NCIt40 C40445

Related Diseases for Luteoma

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Luteoma:



Diseases related to luteoma

Clinical Features for Luteoma

Drugs & Therapeutics for Luteoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Luteoma

Anatomical Context for Luteoma

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33MalaCards
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MalaCards organs/tissues related to Luteoma:

33
Ovary, Uterus, Uterus corpus

Animal Models for Luteoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Luteoma

Sources:
51PubMed
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Articles related to Luteoma:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
Pregnancy Luteoma: A Study of 20 Cases on the Occasion of the 50th Anniversary of its Description by Dr William H. Sternberg, With an Emphasis on the Common Presence of Follicle-like Spaces and Their Diagnostic Implications. (24335664)
2014
2
Luteoma of Pregnancy Associated with Near Complete Virilization of Genetically Female Twins. (24126228)
2013
3
Unilateral luteoma of pregnancy mimicking a malignant ovarian mass on magnetic resonance and ultrasound. (19243065)
2009
4
Luteoma-induced fetal virilization. (20149054)
2009
5
Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development. (19110243)
2009
6
Stromal luteoma and nodular hyperthecosis of the bilateral ovaries associated with atypical endometrial hyperplasia of the uterus. (19883437)
2009
7
Maternal virilization due to luteoma associated with delayed lactation. (18635167)
2008
8
Pregnancy luteoma presenting as ovarian torsion with rupture and intra-abdominal bleeding. (18362993)
2008
9
Stromal luteoma: report of a rare case. (17883070)
2007
10
Krukenberg tumor mimicking pregnancy luteoma. (17852427)
2007
11
Maternal luteoma of pregnancy presenting with virilization of the female infant. (17915067)
2007
12
Luteoma of pregnancy. (17000514)
2006
13
Granulosa theca cell tumor with luteoma in the ovary of a bonnet monkey (Macaca radiata). (16053501)
2005
14
Prenatal diagnosis of female pseudohermaphroditism associated with bilateral luteoma of pregnancy: case report. (11870143)
2002
15
Features of Antley-Bixler syndrome in an infant born to a mother with pregnancy luteoma. (10664233)
2000
16
Congenital adrenal hyperplasia associated with maternal pregnancy luteoma and the Antley-Bixler syndrome. (10726707)
2000
17
Luteoma of pregnancy presenting with massive ascites and markedly elevated CA 125. (10546765)
1999
18
Pregnancy luteoma with granulosa cell proliferation: an unusual hyperplastic lesion arising in pregnancy and mimicking an ovarian neoplasia. (10631723)
1999
19
GnRH receptors and GnRH endocrine effects on luteoma cells. (9225131)
1997
20
Ovarian steroid cell tumor resembling luteoma associated with hyperadrenocorticism (Cushing's disease) in a dog. (9150550)
1997
21
Luteoma of pregnancy. (2157147)
1990
22
Malignant luteoma in a sow. (2551110)
1989
23
High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma. (6094939)
1984
24
In vivo steroid studies in luteoma of pregnancy. (6283444)
1982
25
Incidental pregnancy luteoma associated with ectopic tubo-ovarian pregnancy: evidence in favor of origin from theca interna of an atretic follicle. (233743)
1978
26
Properties of human gonadotrophins eluted from human corpus luteum and mouse luteoma LH-HCG receptors. (188284)
1977
27
Virilization of mother and fetus associated with luteoma of pregnancy: a case report with endocrinologic studies. (197851)
1977
28
Luteoma of pregnancy: ultrastructural features. (177351)
1976
29
Luteoma of pregnancy: case report. (163588)
1975
30
Remission of acanthosis nigricans associated with polycystic ovarian disease and a stromal luteoma. (4360917)
1974
31
Virilizing luteoma of pregnancy. Report of a case with measurements of testosterone and testosterone binding in plasma. (4346682)
1973
32
Gonadotropin receptor of a mouse luteoma: interactions with luteinizing hormone (LH) and its and subunits. (4351508)
1973
33
Luteoma in pregnancy. (4375468)
1973
34
Luteoma of pregnancy. (4335590)
1972
35
Luteoma of pregnancy: steroidogenic and morphologic considerations. (4307340)
1969
36
In vivo and in vitro studies of steroid production by a luteoma and an adrenal cortical carcinoma in mice. (4304996)
1969
37
Ambiguous genitals in a female infant associated with luteoma of pregnancy. Report of a case. (4298215)
1968
38
Steroid content and synthesis in a virilizing luteoma. (4290318)
1967
39
Nodular theca-lutein hyperplasia of pregnancy (so-called "pregnancy luteoma"). A clinical and pathologic study of 15 cases. (4290238)
1967
40
Luteoma of pregnancy. A pseudotumor. (4193143)
1967
41
STROMAL LUTEOMA OF THE OVARY. A DISTINCTIVE TYPE OF LIPOID-CELL TUMOR. (14176990)
1964
42
PSEUDOPRECOCITY IN AN INFANT DUE TO A LUTEOMA OF THE OVARY. (14065997)
1963
43
Sexual precocity due to estrogen- and progesterone-producing organoid luteoma of the ovary. (13300437)
1955
44
Neutral steroids in the urine of a patient with a luteoma of the ovary. (13069593)
1953
45
Evolution of luteoma in intrasplenic ovarian grafts in the guinea-pig. (13081901)
1953
46
Feminizing luteoma of the ovary. (13138065)
1953
47
Luteoma of the ovary. (14918776)
1952
48
The ovarian theca cell. III. An unusual ovarian tumour: presentation of a tumour with patterns reminiscent of arrhenoblastoma, adrenal tumour and luteoma and a discussion of the probable histogenesis of these neoplasms. (14779197)
1950
49
Transplantability of induced granulosa cell tumors and of luteoma in mice; secondary effects of these growths. (21024146)
1946
50
The origin of adrenal-like tumor of the ovary (hypernephroma of ovary, adrenal tumor of ovary, masculinovoblastoma, luteoma, luteinoma). (20992590)
1946

Genetic Variations for Luteoma

Expression for genes affiliated with Luteoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Luteoma

Search GEO for disease gene expression data for Luteoma.

Pathways for genes affiliated with Luteoma

Compounds for genes affiliated with Luteoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
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Compounds related to Luteoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1nafarelin45 60 29 1112.7CYP21A2, CGA
217-hydroxypregnenolone459.7CGA, CYP21A2
311 deoxycortisol459.7CYP21A2, CGA
4leuprolide acetate459.7CYP21A2, CGA
5clomiphene citrate459.7CGA, CYP21A2
617-hydroxyprogesterone45 2410.6CYP21A2, CGA
73beta-hydroxysteroid459.6CGA, CYP21A2
8dehydroepiandrosterone sulfate459.6CYP21A2, CGA
917beta-hydroxysteroid459.6CYP21A2, CGA
10phenytoin45 50 29 1112.6CGA, CYP21A2
11androstenedione45 2410.5CYP21A2, CGA
12thyroxine45 2410.4CYP21A2, CGA
13deoxyribonucleic acid459.4SRY, CYP21A2
14carbon459.3CGA, CYP21A2
15ribonucleic acid459.3CYP21A2, CGA
16biotin45 11 2411.3CYP21A2, SRY
17agarose459.2SRY, CYP21A2
18gnrh459.2CYP21A2, CGA
19epinephrine45 11 2411.0CYP21A2, CGA
20dihydrotestosterone45 29 11 2411.9SRY, CYP21A2, CGA
21estradiol45 11 2410.8SRY, CYP21A2, CGA
22testosterone45 60 11 2411.7SRY, CYP21A2, CGA
23steroid458.7CGA, CYP21A2, SRY

GO Terms for genes affiliated with Luteoma

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Sources for Luteoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet