MCID: LTM002
MIFTS: 29

Luteoma malady

Category: Reproductive diseases

Aliases & Classifications for Luteoma

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Aliases & Descriptions for Luteoma:

Name: Luteoma 11 49 13 67
Leuteoma of Pregnancy 11
 
Luteoma of Pregnancy 11

Classifications:



External Ids:

Disease Ontology11 DOID:7880
NCIt44 C40445

Summaries for Luteoma

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Wikipedia:70 A luteoma is a tumor that occurs in the ovaries during pregnancy. It is associated with an increase of... more...

MalaCards based summary: Luteoma, also known as leuteoma of pregnancy, is related to dfna2 nonsyndromic hearing loss and vasculogenic impotence. An important gene associated with Luteoma is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways are Corticotropin-releasing hormone and Central carbon metabolism in cancer. Affiliated tissues include ovary and uterus, and related mouse phenotype reproductive system.

Related Diseases for Luteoma

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Diseases related to Luteoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1dfna2 nonsyndromic hearing loss10.3CYP21A2, FGFR2
2vasculogenic impotence10.2CYP21A2, STAR
3flnb-related disorders10.2FGFR2, FGFR3
4plasmalogens synthesis deficiency isolated10.2FGFR2, FGFR3
5benign shuddering attacks10.2CYP21A2, STAR
6trigonocephaly 110.2FGFR2, FGFR3
7bladder cancer, somatic10.2FGFR2, FGFR3
8apert syndrome10.2FGFR2, FGFR3
9hypogonadotropic hypogonadism 2 with or without anosmia10.2FGFR2, FGFR3
10central nervous system leukemia10.2FGFR2, FGFR3
11accommodative esotropia10.2FGFR2, FGFR3
12crouzon syndrome with acanthosis nigricans10.2FGFR2, FGFR3
13thanatophoric dysplasia, type i10.2FGFR2, FGFR3
14glaucomatocyclitic crisis10.2FGFR2, FGFR3
15antley-bixler syndrome without genital anomalies or disordered steroidogenesis10.2FGFR2, FGFR3
16scleredema adultorum10.1FGFR2, FGFR3
17first-degree atrioventricular block10.1CYP21A2, STAR
18beare-stevenson cutis gyrata syndrome10.1FGFR2, FGFR3
19thanatophoric dysplasia, type ii10.1FGFR2, FGFR3
20ischemic bone disease10.1FGFR2, FGFR3
21hypochondroplasia10.1FGFR2, FGFR3
22adrenal cortex disease10.0CYP21A2, STAR
23epilepsy, idiopathic generalized 1110.0CYP19A1, CYP21A2
24craniosynostosis, type 110.0FGFR2, FGFR3
25jackson-weiss syndrome9.9FGFR2, FGFR3
26y-linked disease9.9FGFR2, FGFR3
27klinefelter's syndrome9.8CYP19A1, STAR
28serous conjunctivitis except viral9.8FGFR2, FGFR3
29adrenal cortical carcinoma9.8
30ovarian disease9.8
31acanthosis nigricans9.8
32pseudohermaphroditism9.8
33progesterone-receptor positive breast cancer9.8CYP19A1, FGFR2
34pleural empyema9.7CGA, CYP19A1
35hypospadias 1, x-linked9.7CGA, CYP19A1
36ovarian hyperstimulation syndrome9.6CGA, CYP19A1
37crohn's disease9.6FGFR2, FGFR3
38toxic encephalopathy9.5CGA, CYP19A1
39mite infestation8.7CYP19A1, CYP21A2, FGFR2, FGFR3, STAR

Graphical network of the top 20 diseases related to Luteoma:



Diseases related to luteoma

Symptoms for Luteoma

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Drugs & Therapeutics for Luteoma

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Interventional clinical trials:

Genetic Tests for Luteoma

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Anatomical Context for Luteoma

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MalaCards organs/tissues related to Luteoma:

35
Ovary, Uterus

Animal Models for Luteoma or affiliated genes

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MGI Mouse Phenotypes related to Luteoma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.5CGA, CYP19A1, FGFR2, FGFR3, STAR

Publications for Luteoma

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Articles related to Luteoma:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Luteoma of Pregnancy. (28081022)
2017
2
A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling. (27355981)
2016
3
A Metastatic Ovarian Tumor Mimicking Pregnancy Luteoma Found during Puerperium. (26726013)
2016
4
Pregnancy Luteoma: A Study of 20 Cases on the Occasion of the 50th Anniversary of its Description by Dr William H. Sternberg, With an Emphasis on the Common Presence of Follicle-like Spaces and Their Diagnostic Implications. (24335664)
2014
5
Luteoma of Pregnancy Associated with Near Complete Virilization of Genetically Female Twins. (24126228)
2013
6
Stromal luteoma and nodular hyperthecosis of the bilateral ovaries associated with atypical endometrial hyperplasia of the uterus. (19883437)
2009
7
Unilateral luteoma of pregnancy mimicking a malignant ovarian mass on magnetic resonance and ultrasound. (19243065)
2009
8
Maternal virilization due to luteoma associated with delayed lactation. (18635167)
2008
9
Pregnancy luteoma presenting as ovarian torsion with rupture and intra-abdominal bleeding. (18362993)
2008
10
Stromal luteoma: report of a rare case. (17883070)
2007
11
Luteoma of pregnancy. (17000514)
2006
12
MR imaging of pregnancy luteoma: a case report and correlation with the clinical features. (15782020)
2005
13
Granulosa theca cell tumor with luteoma in the ovary of a bonnet monkey (Macaca radiata). (16053501)
2005
14
Magnetic resonance imaging of pregnancy luteoma. (12703004)
2003
15
Prenatal diagnosis of female pseudohermaphroditism associated with bilateral luteoma of pregnancy: case report. (11870143)
2002
16
Features of Antley-Bixler syndrome in an infant born to a mother with pregnancy luteoma. (10664233)
2000
17
Congenital adrenal hyperplasia associated with maternal pregnancy luteoma and the Antley-Bixler syndrome. (10726707)
2000
18
Luteoma of pregnancy presenting with massive ascites and markedly elevated CA 125. (10546765)
1999
19
Pregnancy luteoma with granulosa cell proliferation: an unusual hyperplastic lesion arising in pregnancy and mimicking an ovarian neoplasia. (10631723)
1999
20
Ovarian steroid cell tumor resembling luteoma associated with hyperadrenocorticism (Cushing's disease) in a dog. (9150550)
1997
21
A gonadotrophin dependent stromal luteoma: a rare cause of post-menopausal virilization. (8548951)
1995
22
Luteoma of pregnancy: masculinisation of a female fetus prevented by placental aromatisation. (1335753)
1992
23
Luteoma of pregnancy. (2157147)
1990
24
High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma. (6094939)
1984
25
In vivo steroid studies in luteoma of pregnancy. (6283444)
1982
26
A case of virilizing luteoma. (6244616)
1980
27
Incidental pregnancy luteoma associated with ectopic tubo-ovarian pregnancy: evidence in favor of origin from theca interna of an atretic follicle. (233743)
1978
28
Differential maternal-fetal response to androgenizing luteoma or hyperreactio luteinalis. (205819)
1978
29
Properties of human gonadotrophins eluted from human corpus luteum and mouse luteoma LH-HCG receptors. (188284)
1977
30
Virilization of mother and fetus associated with luteoma of pregnancy: a case report with endocrinologic studies. (197851)
1977
31
Luteoma of pregnancy: ultrastructural features. (177351)
1976
32
Letter: Luteoma of pregnancy. (170823)
1975
33
Luteoma of pregnancy: report of a case and review of the literature. (163309)
1975
34
Remission of acanthosis nigricans associated with polycystic ovarian disease and a stromal luteoma. (4360917)
1974
35
Gonadotropin receptor of a mouse luteoma: interactions with luteinizing hormone (LH) and its and subunits. (4351508)
1973
36
Virilizing luteoma of pregnancy. Report of a case with measurements of testosterone and testosterone binding in plasma. (4346682)
1973
37
Luteoma of pregnancy. (4335590)
1972
38
Luteoma of pregnancy. (4319381)
1970
39
Luteoma of pregnancy: recurrent or persistent? (5366428)
1969
40
Luteoma of pregnancy. Report of a case. (4317074)
1968
41
Steroid content and synthesis in a virilizing luteoma. (4290318)
1967
42
STROMAL LUTEOMA OF THE OVARY. A DISTINCTIVE TYPE OF LIPOID-CELL TUMOR. (14176990)
1964
43
PSEUDOPRECOCITY IN AN INFANT DUE TO A LUTEOMA OF THE OVARY. (14065997)
1963
44
Neutral steroids in the urine of a patient with a luteoma of the ovary. (13069593)
1953
45
Feminizing luteoma of the ovary. (13138065)
1953
46
Luteoma of the ovary. (14918776)
1952
47
The ovarian theca cell. III. An unusual ovarian tumour: presentation of a tumour with patterns reminiscent of arrhenoblastoma, adrenal tumour and luteoma and a discussion of the probable histogenesis of these neoplasms. (14779197)
1950
48
Transplantability of induced granulosa cell tumors and of luteoma in mice; secondary effects of these growths. (21024146)
1946
49
The origin of adrenal-like tumor of the ovary (hypernephroma of ovary, adrenal tumor of ovary, masculinovoblastoma, luteoma, luteinoma). (20992590)
1946
50
Luteoma of the ovary; a case showing decidualization of the endometrium and a high pregnanediol excretion rate. (20984666)
1946

Variations for Luteoma

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Expression for genes affiliated with Luteoma

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Search GEO for disease gene expression data for Luteoma.

Pathways for genes affiliated with Luteoma

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Pathways related to Luteoma according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathwaysScoreTop Affiliating Genes
19.5CYP21A2, STAR
29.5FGFR2, FGFR3
3
Show member pathways
9.5FGFR2, FGFR3
49.5FGFR2, FGFR3
59.5FGFR2, FGFR3
6
Show member pathways
9.2CYP19A1, CYP21A2
79.0CGA, CYP19A1
89.0CGA, CYP19A1
9
Show member pathways
8.9CGA, CYP21A2, STAR
108.5CGA, CYP19A1, STAR
11
Show member pathways
8.4CGA, FGFR2, FGFR3, STAR
12
Show member pathways
8.1CGA, CYP19A1, CYP21A2, STAR

GO Terms for genes affiliated with Luteoma

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Biological processes related to Luteoma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.1FGFR2, FGFR3
2phosphatidylinositol phosphorylationGO:004685410.0FGFR2, FGFR3
3regulation of phosphatidylinositol 3-kinase signalingGO:001406610.0FGFR2, FGFR3
4fibroblast growth factor receptor signaling pathwayGO:000854310.0FGFR2, FGFR3
5bone mineralizationGO:00302829.9FGFR2, FGFR3
6positive regulation of phospholipase activityGO:00105189.9FGFR2, FGFR3
7bone morphogenesisGO:00603499.7FGFR2, FGFR3
8positive regulation of MAPK cascadeGO:00434109.6FGFR2, FGFR3
9estrogen biosynthetic processGO:00067039.5CYP19A1, STAR
10sterol metabolic processGO:00161259.5CYP19A1, CYP21A2
11cell-cell signalingGO:00072679.0CGA, FGFR2, FGFR3
12steroid biosynthetic processGO:00066949.0CYP19A1, CYP21A2, STAR
13positive regulation of cell proliferationGO:00082848.9CGA, FGFR2, FGFR3

Molecular functions related to Luteoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:000500710.0FGFR2, FGFR3
21-phosphatidylinositol-3-kinase activityGO:00163039.9FGFR2, FGFR3
3phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.9FGFR2, FGFR3
4fibroblast growth factor bindingGO:00171349.7FGFR2, FGFR3
5steroid hydroxylase activityGO:00083959.2CYP19A1, CYP21A2

Sources for Luteoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet