MCID: LTM002
MIFTS: 30

Luteoma malady

Categories: Reproductive diseases

Aliases & Classifications for Luteoma

Aliases & Descriptions for Luteoma:

Name: Luteoma 12 52 14 69
Leuteoma of Pregnancy 12
Luteoma of Pregnancy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7880
NCIt 47 C40445
UMLS 69 C1517842

Summaries for Luteoma

MalaCards based summary : Luteoma, also known as leuteoma of pregnancy, is related to dyt1 early-onset isolated dystonia and epithelial predominant pulmonary blastoma. An important gene associated with Luteoma is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Insulin secretion and Angiogenesis (CST). Affiliated tissues include ovary and uterus, and related phenotype is reproductive system.

Wikipedia : 71 A luteoma is a tumor that occurs in the ovaries during pregnancy. It is associated with an increase of... more...

Related Diseases for Luteoma

Diseases related to Luteoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 dyt1 early-onset isolated dystonia 10.2 CYP21A2 FGFR2
2 epithelial predominant pulmonary blastoma 10.2 CYP21A2 STAR
3 familial porphyria cutanea tarda 10.1 FGFR2 FGFR3
4 clear cell acanthoma 10.1 CYP21A2 STAR
5 hartsfield syndrome 10.1 FGFR2 FGFR3
6 microphthalmia, syndromic 9 10.1 CYP21A2 STAR
7 pointer syndrome 10.1 FGFR2 FGFR3
8 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 10.1 FGFR2 FGFR3
9 osteoglophonic dysplasia 10.1 FGFR2 FGFR3
10 jackson-weiss syndrome 10.1 CYP21A2 STAR
11 aica-ribosiduria due to atic deficiency 10.1 FGFR2 FGFR3
12 crouzon syndrome with acanthosis nigricans 10.1 FGFR2 FGFR3
13 muenke syndrome 10.1 FGFR2 FGFR3
14 deafness, autosomal recessive 61 10.1 CYP21A2 FGFR3
15 lingual-facial-buccal dyskinesia 10.1 FGFR2 FGFR3
16 sp7-related osteogenesis imperfecta 10.1 FGFR2 FGFR3
17 leg dermatosis 10.1 FGFR2 FGFR3
18 scaphocephaly, maxillary retrusion, and mental retardation 10.1 FGFR2 FGFR3
19 apert syndrome 10.1 FGFR2 FGFR3
20 cervical cancer, somatic 10.1 FGFR2 FGFR3
21 second-degree atrioventricular block 10.1 CYP21A2 STAR
22 thanatophoric dysplasia, type i 10.1 FGFR2 FGFR3
23 saddan 10.1 FGFR2 FGFR3
24 loeffler endocarditis 10.1 CYP21A2 STAR
25 hypermobility syndrome 10.0 CYP21A2 STAR
26 borderline personality disorder 10.0 CYP19A1 CYP21A2
27 leukoencephalopathy with ataxia 10.0 CYP19A1 CYP21A2
28 robinow-sorauf syndrome 10.0 FGFR2 FGFR3
29 sphingolipidosis 10.0 CYP19A1 CYP21A2
30 bone structure disease 10.0 FGFR2 FGFR3
31 hypoparathyroidism 10.0 FGFR2 FGFR3
32 autosomal genetic disease 10.0 FGFR2 FGFR3
33 pelvic muscle wasting 10.0 CYP19A1 CYP21A2
34 bardet-biedl syndrome 1 10.0 CGA CYP19A1
35 progesterone-receptor negative breast cancer 9.9 CYP19A1 FGFR2
36 atrophy of testis 9.9 FGFR2 FGFR3
37 congenital articular rigidity 9.9 CGA CYP19A1
38 hypospadias 1, x-linked 9.9 CGA CYP19A1
39 capillary disease 9.9 CGA CYP19A1
40 epidural spinal canal meningioma 9.9 CGA CYP19A1
41 spinocerebellar ataxia 25 9.9 CGA CYP19A1
42 antley-bixler syndrome 9.9
43 bent bone dysplasia syndrome 9.9 CYP19A1 CYP21A2 FGFR2
44 epidemic typhus 9.9 CYP19A1 CYP21A2 FGFR2
45 hypogonadotropic hypogonadism 2 with or without anosmia 9.9 FGFR2 FGFR3
46 liver sarcoma 9.8 CYP19A1 CYP21A2 STAR
47 glioma susceptibility 1 9.8 CYP19A1 CYP21A2 STAR
48 adrenal cortical carcinoma 9.7
49 congenital adrenal hyperplasia 9.7
50 ovarian disease 9.7

Graphical network of the top 20 diseases related to Luteoma:



Diseases related to Luteoma

Symptoms & Phenotypes for Luteoma

MGI Mouse Phenotypes related to Luteoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.02 CGA CYP19A1 FGFR2 FGFR3 STAR

Drugs & Therapeutics for Luteoma

Search Clinical Trials , NIH Clinical Center for Luteoma

Genetic Tests for Luteoma

Anatomical Context for Luteoma

MalaCards organs/tissues related to Luteoma:

39
Ovary, Uterus

Publications for Luteoma

Articles related to Luteoma:

(show top 50) (show all 76)
id Title Authors Year
1
Luteoma of Pregnancy. ( 28081022 )
2017
2
A Metastatic Ovarian Tumor Mimicking Pregnancy Luteoma Found during Puerperium. ( 26726013 )
2016
3
Pregnancy luteoma: A rare case report. ( 27857898 )
2016
4
A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling. ( 27355981 )
2016
5
Luteoma of Pregnancy Presenting with Severe Maternal Virilisation: A Case Report. ( 27660728 )
2016
6
Pregnancy luteoma followed with massive ascites and elevated CA125 after ovulation induction therapy: a case report and review of literatures. ( 25785161 )
2015
7
Bilateral pregnancy luteoma: a case report. ( 25337317 )
2014
8
Pregnancy Luteoma: A Study of 20 Cases on the Occasion of the 50th Anniversary of its Description by Dr William H. Sternberg, With an Emphasis on the Common Presence of Follicle-like Spaces and Their Diagnostic Implications. ( 24335664 )
2014
9
Stromal luteoma of the ovary: A rare ovarian pathology. ( 25140903 )
2014
10
Luteoma of Pregnancy Associated with Near Complete Virilization of Genetically Female Twins. ( 24126228 )
2013
11
Stromal luteoma and nodular hyperthecosis of the bilateral ovaries associated with atypical endometrial hyperplasia of the uterus. ( 19883437 )
2009
12
Unilateral luteoma of pregnancy mimicking a malignant ovarian mass on magnetic resonance and ultrasound. ( 19243065 )
2009
13
Luteoma-induced fetal virilization. ( 20149054 )
2009
14
Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development. ( 19110243 )
2009
15
Maternal virilization due to luteoma associated with delayed lactation. ( 18635167 )
2008
16
Pregnancy luteoma presenting as ovarian torsion with rupture and intra-abdominal bleeding. ( 18362993 )
2008
17
Ovarian stromal luteoma in a patient with endometrial carcinoma. ( 18412799 )
2008
18
Stromal luteoma: report of a rare case. ( 17883070 )
2007
19
Krukenberg tumor mimicking pregnancy luteoma. ( 17852427 )
2007
20
Maternal luteoma of pregnancy presenting with virilization of the female infant. ( 17915067 )
2007
21
Luteoma of pregnancy. ( 17000514 )
2006
22
MR imaging of pregnancy luteoma: a case report and correlation with the clinical features. ( 15782020 )
2005
23
Granulosa theca cell tumor with luteoma in the ovary of a bonnet monkey (Macaca radiata). ( 16053501 )
2005
24
Magnetic resonance imaging of pregnancy luteoma. ( 12703004 )
2003
25
Prenatal diagnosis of female pseudohermaphroditism associated with bilateral luteoma of pregnancy: case report. ( 11870143 )
2002
26
Congenital adrenal hyperplasia associated with maternal pregnancy luteoma and the Antley-Bixler syndrome. ( 10726707 )
2000
27
Features of Antley-Bixler syndrome in an infant born to a mother with pregnancy luteoma. ( 10664233 )
2000
28
Luteoma of pregnancy: sonographic findings in two cases. ( 11127014 )
2000
29
Pregnancy luteoma with granulosa cell proliferation: an unusual hyperplastic lesion arising in pregnancy and mimicking an ovarian neoplasia. ( 10631723 )
1999
30
Luteoma of pregnancy presenting with massive ascites and markedly elevated CA 125. ( 10546765 )
1999
31
GnRH receptors and GnRH endocrine effects on luteoma cells. ( 9225131 )
1997
32
Ovarian steroid cell tumor resembling luteoma associated with hyperadrenocorticism (Cushing's disease) in a dog. ( 9150550 )
1997
33
A gonadotrophin dependent stromal luteoma: a rare cause of post-menopausal virilization. ( 8548951 )
1995
34
Luteoma of pregnancy: masculinisation of a female fetus prevented by placental aromatisation. ( 1335753 )
1992
35
Luteoma of pregnancy. ( 2157147 )
1990
36
Malignant luteoma in a sow. ( 2551110 )
1989
37
Stromal luteoma of the ovary: a clinicopathological analysis of 25 cases. ( 2826353 )
1987
38
Luteoma of pregnancy. ( 6330914 )
1984
39
High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma. ( 6094939 )
1984
40
In vivo steroid studies in luteoma of pregnancy. ( 6283444 )
1982
41
A case of virilizing luteoma. ( 6244616 )
1980
42
Differential maternal-fetal response to androgenizing luteoma or hyperreactio luteinalis. ( 205819 )
1978
43
Incidental pregnancy luteoma associated with ectopic tubo-ovarian pregnancy: evidence in favor of origin from theca interna of an atretic follicle. ( 233743 )
1978
44
Virilization of mother and fetus associated with luteoma of pregnancy: a case report with endocrinologic studies. ( 197851 )
1977
45
Properties of human gonadotrophins eluted from human corpus luteum and mouse luteoma LH-HCG receptors. ( 188284 )
1977
46
Luteoma of pregnancy: ultrastructural features. ( 177351 )
1976
47
Luteoma of pregnancy: report of a case and review of the literature. ( 163309 )
1975
48
Letter: Luteoma of pregnancy. ( 170823 )
1975
49
Luteoma of pregnancy: case report. ( 163588 )
1975
50
Remission of acanthosis nigricans associated with polycystic ovarian disease and a stromal luteoma. ( 4360917 )
1974

Variations for Luteoma

Expression for Luteoma

Search GEO for disease gene expression data for Luteoma.

Pathways for Luteoma

GO Terms for Luteoma

Biological processes related to Luteoma according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 CGA FGFR2 FGFR3
2 cell-cell signaling GO:0007267 9.63 CGA FGFR2 FGFR3
3 positive regulation of MAPK cascade GO:0043410 9.55 FGFR2 FGFR3
4 fibroblast growth factor receptor signaling pathway GO:0008543 9.52 FGFR2 FGFR3
5 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.51 FGFR2 FGFR3
6 cellular response to transforming growth factor beta stimulus GO:0071560 9.49 FGFR2 STAR
7 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.48 FGFR2 FGFR3
8 bone mineralization GO:0030282 9.43 FGFR2 FGFR3
9 bone morphogenesis GO:0060349 9.4 FGFR2 FGFR3
10 sterol metabolic process GO:0016125 9.37 CYP19A1 CYP21A2
11 estrogen biosynthetic process GO:0006703 9.32 CYP19A1 STAR
12 positive regulation of phospholipase activity GO:0010518 9.26 FGFR2 FGFR3
13 endochondral bone growth GO:0003416 9.16 FGFR2 FGFR3
14 testosterone biosynthetic process GO:0061370 8.96 CYP19A1 STAR
15 steroid biosynthetic process GO:0006694 8.8 CYP19A1 CYP21A2 STAR

Molecular functions related to Luteoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.4 CYP19A1 CYP21A2
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.37 FGFR2 FGFR3
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.32 FGFR2 FGFR3
4 1-phosphatidylinositol-3-kinase activity GO:0016303 9.26 FGFR2 FGFR3
5 fibroblast growth factor binding GO:0017134 9.16 FGFR2 FGFR3
6 steroid hydroxylase activity GO:0008395 8.96 CYP19A1 CYP21A2
7 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR2 FGFR3

Sources for Luteoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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