MCID: LTM002
MIFTS: 29

Luteoma malady

Category: Reproductive diseases

Aliases & Classifications for Luteoma

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Aliases & Descriptions for Luteoma:

Name: Luteoma 11 50 13 68
Leuteoma of Pregnancy 11
 
Luteoma of Pregnancy 11

Classifications:



External Ids:

Disease Ontology11 DOID:7880
NCIt45 C40445

Summaries for Luteoma

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Wikipedia:71 A luteoma is a tumor that occurs in the ovaries during pregnancy. It is associated with an increase of... more...

MalaCards based summary: Luteoma, also known as leuteoma of pregnancy, is related to dfna2 nonsyndromic hearing loss and vasculogenic impotence. An important gene associated with Luteoma is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways are Corticotropin-releasing hormone and Central carbon metabolism in cancer. Affiliated tissues include ovary and uterus, and related mouse phenotype reproductive system.

Related Diseases for Luteoma

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Diseases related to Luteoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1dfna2 nonsyndromic hearing loss10.3CYP21A2, FGFR2
2vasculogenic impotence10.2CYP21A2, STAR
3flnb-related disorders10.2FGFR2, FGFR3
4plasmalogens synthesis deficiency isolated10.2FGFR2, FGFR3
5benign shuddering attacks10.2CYP21A2, STAR
6trigonocephaly 110.2FGFR2, FGFR3
7bladder cancer, somatic10.2FGFR2, FGFR3
8apert syndrome10.2FGFR2, FGFR3
9hypogonadotropic hypogonadism 2 with or without anosmia10.2FGFR2, FGFR3
10central nervous system leukemia10.2FGFR2, FGFR3
11accommodative esotropia10.2FGFR2, FGFR3
12crouzon syndrome with acanthosis nigricans10.2FGFR2, FGFR3
13thanatophoric dysplasia, type i10.2FGFR2, FGFR3
14glaucomatocyclitic crisis10.2FGFR2, FGFR3
15antley-bixler syndrome without genital anomalies or disordered steroidogenesis10.2FGFR2, FGFR3
16scleredema adultorum10.1FGFR2, FGFR3
17first-degree atrioventricular block10.1CYP21A2, STAR
18beare-stevenson cutis gyrata syndrome10.1FGFR2, FGFR3
19thanatophoric dysplasia, type ii10.1FGFR2, FGFR3
20ischemic bone disease10.1FGFR2, FGFR3
21hypochondroplasia10.1FGFR2, FGFR3
22adrenal cortex disease10.0CYP21A2, STAR
23epilepsy, idiopathic generalized 1110.0CYP19A1, CYP21A2
24craniosynostosis, type 110.0FGFR2, FGFR3
25jackson-weiss syndrome9.9FGFR2, FGFR3
26y-linked disease9.9FGFR2, FGFR3
27klinefelter's syndrome9.8CYP19A1, STAR
28serous conjunctivitis except viral9.8FGFR2, FGFR3
29adrenal cortical carcinoma9.8
30ovarian disease9.8
31acanthosis nigricans9.8
32pseudohermaphroditism9.8
33progesterone-receptor positive breast cancer9.8CYP19A1, FGFR2
34pleural empyema9.7CGA, CYP19A1
35hypospadias 1, x-linked9.7CGA, CYP19A1
36ovarian hyperstimulation syndrome9.6CGA, CYP19A1
37crohn's disease9.6FGFR2, FGFR3
38toxic encephalopathy9.5CGA, CYP19A1
39mite infestation8.7CYP19A1, CYP21A2, FGFR2, FGFR3, STAR

Graphical network of the top 20 diseases related to Luteoma:



Diseases related to luteoma

Symptoms & Phenotypes for Luteoma

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MGI Mouse Phenotypes related to Luteoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.5CGA, CYP19A1, FGFR2, FGFR3, STAR

Drugs & Therapeutics for Luteoma

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Interventional clinical trials:

Genetic Tests for Luteoma

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Anatomical Context for Luteoma

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MalaCards organs/tissues related to Luteoma:

36
Ovary, Uterus

Publications for Luteoma

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Articles related to Luteoma:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Luteoma of Pregnancy. (28081022)
2017
2
A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling. (27355981)
2016
3
A Metastatic Ovarian Tumor Mimicking Pregnancy Luteoma Found during Puerperium. (26726013)
2016
4
Luteoma of Pregnancy Presenting with Severe Maternal Virilisation: A Case Report. (27660728)
2016
5
Pregnancy luteoma: A rare case report. (27857898)
2016
6
Pregnancy luteoma followed with massive ascites and elevated CA125 after ovulation induction therapy: a case report and review of literatures. (25785161)
2015
7
Pregnancy Luteoma: A Study of 20 Cases on the Occasion of the 50th Anniversary of its Description by Dr William H. Sternberg, With an Emphasis on the Common Presence of Follicle-like Spaces and Their Diagnostic Implications. (24335664)
2014
8
Bilateral pregnancy luteoma: a case report. (25337317)
2014
9
Stromal luteoma of the ovary: A rare ovarian pathology. (25140903)
2014
10
Luteoma of Pregnancy Associated with Near Complete Virilization of Genetically Female Twins. (24126228)
2013
11
Stromal luteoma and nodular hyperthecosis of the bilateral ovaries associated with atypical endometrial hyperplasia of the uterus. (19883437)
2009
12
Unilateral luteoma of pregnancy mimicking a malignant ovarian mass on magnetic resonance and ultrasound. (19243065)
2009
13
Luteoma-induced fetal virilization. (20149054)
2009
14
Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development. (19110243)
2009
15
Maternal virilization due to luteoma associated with delayed lactation. (18635167)
2008
16
Pregnancy luteoma presenting as ovarian torsion with rupture and intra-abdominal bleeding. (18362993)
2008
17
Ovarian stromal luteoma in a patient with endometrial carcinoma. (18412799)
2008
18
Stromal luteoma: report of a rare case. (17883070)
2007
19
Krukenberg tumor mimicking pregnancy luteoma. (17852427)
2007
20
Maternal luteoma of pregnancy presenting with virilization of the female infant. (17915067)
2007
21
Luteoma of pregnancy. (17000514)
2006
22
MR imaging of pregnancy luteoma: a case report and correlation with the clinical features. (15782020)
2005
23
Granulosa theca cell tumor with luteoma in the ovary of a bonnet monkey (Macaca radiata). (16053501)
2005
24
Magnetic resonance imaging of pregnancy luteoma. (12703004)
2003
25
Prenatal diagnosis of female pseudohermaphroditism associated with bilateral luteoma of pregnancy: case report. (11870143)
2002
26
Features of Antley-Bixler syndrome in an infant born to a mother with pregnancy luteoma. (10664233)
2000
27
Congenital adrenal hyperplasia associated with maternal pregnancy luteoma and the Antley-Bixler syndrome. (10726707)
2000
28
Luteoma of pregnancy: sonographic findings in two cases. (11127014)
2000
29
Luteoma of pregnancy presenting with massive ascites and markedly elevated CA 125. (10546765)
1999
30
Pregnancy luteoma with granulosa cell proliferation: an unusual hyperplastic lesion arising in pregnancy and mimicking an ovarian neoplasia. (10631723)
1999
31
Ovarian steroid cell tumor resembling luteoma associated with hyperadrenocorticism (Cushing's disease) in a dog. (9150550)
1997
32
GnRH receptors and GnRH endocrine effects on luteoma cells. (9225131)
1997
33
A gonadotrophin dependent stromal luteoma: a rare cause of post-menopausal virilization. (8548951)
1995
34
Luteoma of pregnancy: masculinisation of a female fetus prevented by placental aromatisation. (1335753)
1992
35
Luteoma of pregnancy. (2157147)
1990
36
Malignant luteoma in a sow. (2551110)
1989
37
Stromal luteoma of the ovary: a clinicopathological analysis of 25 cases. (2826353)
1987
38
High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma. (6094939)
1984
39
Luteoma of pregnancy. (6330914)
1984
40
In vivo steroid studies in luteoma of pregnancy. (6283444)
1982
41
A case of virilizing luteoma. (6244616)
1980
42
Incidental pregnancy luteoma associated with ectopic tubo-ovarian pregnancy: evidence in favor of origin from theca interna of an atretic follicle. (233743)
1978
43
Differential maternal-fetal response to androgenizing luteoma or hyperreactio luteinalis. (205819)
1978
44
Properties of human gonadotrophins eluted from human corpus luteum and mouse luteoma LH-HCG receptors. (188284)
1977
45
Virilization of mother and fetus associated with luteoma of pregnancy: a case report with endocrinologic studies. (197851)
1977
46
Luteoma of pregnancy: ultrastructural features. (177351)
1976
47
Letter: Luteoma of pregnancy. (170823)
1975
48
Luteoma of pregnancy: report of a case and review of the literature. (163309)
1975
49
Luteoma of pregnancy: case report. (163588)
1975
50
Remission of acanthosis nigricans associated with polycystic ovarian disease and a stromal luteoma. (4360917)
1974

Variations for Luteoma

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Expression for genes affiliated with Luteoma

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Search GEO for disease gene expression data for Luteoma.

Pathways for genes affiliated with Luteoma

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Pathways related to Luteoma according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathwaysScoreTop Affiliating Genes
19.5CYP21A2, STAR
29.5FGFR2, FGFR3
3
Show member pathways
9.5FGFR2, FGFR3
49.5FGFR2, FGFR3
59.5FGFR2, FGFR3
6
Show member pathways
9.2CYP19A1, CYP21A2
79.0CGA, CYP19A1
89.0CGA, CYP19A1
9
Show member pathways
8.9CGA, CYP21A2, STAR
108.5CGA, CYP19A1, STAR
11
Show member pathways
8.4CGA, FGFR2, FGFR3, STAR
12
Show member pathways
8.1CGA, CYP19A1, CYP21A2, STAR

GO Terms for genes affiliated with Luteoma

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Biological processes related to Luteoma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1bone mineralizationGO:003028210.2FGFR2, FGFR3
2bone morphogenesisGO:006034910.2FGFR2, FGFR3
3fibroblast growth factor receptor signaling pathwayGO:000854310.2FGFR2, FGFR3
4phosphatidylinositol phosphorylationGO:004685410.2FGFR2, FGFR3
5phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.2FGFR2, FGFR3
6positive regulation of MAPK cascadeGO:004341010.1FGFR2, FGFR3
7positive regulation of phospholipase activityGO:001051810.1FGFR2, FGFR3
8regulation of phosphatidylinositol 3-kinase signalingGO:001406610.0FGFR2, FGFR3
9estrogen biosynthetic processGO:00067039.8CYP19A1, STAR
10cell-cell signalingGO:00072679.6CGA, FGFR2, FGFR3
11positive regulation of cell proliferationGO:00082849.5CGA, FGFR2, FGFR3
12sterol metabolic processGO:00161259.2CYP19A1, CYP21A2
13steroid biosynthetic processGO:00066949.1CYP19A1, CYP21A2, STAR

Molecular functions related to Luteoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
11-phosphatidylinositol-3-kinase activityGO:001630310.0FGFR2, FGFR3
2fibroblast growth factor bindingGO:001713410.0FGFR2, FGFR3
3fibroblast growth factor-activated receptor activityGO:000500710.0FGFR2, FGFR3
4phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.9FGFR2, FGFR3
5steroid hydroxylase activityGO:00083959.2CYP19A1, CYP21A2

Sources for Luteoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet