MCID: LYM017
MIFTS: 67

Lyme Disease malady

Infectious diseases, Neuronal diseases categories

Summaries for Lyme Disease

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Lyme disease is a bacterial infection you get from the bite of an infected tick. the first symptom is usually a rash, which may look like a bull's eye. as the infection spreads, you may have a fever a headache muscle and joint aches a stiff neck fatigue lyme disease can be hard to diagnose because you may not have noticed a tick bite. also, many of its symptoms are like those of the flu and other diseases. in the early stages, your health care provider will look at your symptoms and medical history, to figure out whether you have lyme disease. lab tests may help at this stage, but may not always give a clear answer. in the later stages of the disease, a different lab test can confirm whether you have it. antibiotics can cure most cases of lyme disease. the sooner treatment begins, the quicker and more complete the recovery. after treatment, some patients may still have muscle or joint aches and nervous system symptoms. this is called post-lyme disease syndrome (plds). long-term antibiotics have not been shown to help with plds. however, there are ways to help with the symptoms of plds, and most patients do get better with time. nih: national institute of allergy and infectious diseases

MalaCards: Lyme Disease, also known as lyme neuroborreliosis, is related to thrombocytopenia and arthritis, and has symptoms including articular/joint pain/arthralgia, fever/chilling and asthenia/fatigue/weakness. An important gene associated with Lyme Disease is CD40LG (CD40 ligand), and among its related pathways are Th17 Differentiation and NF-kappaB Signaling. The compounds cycloheximide and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and heart, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A primary bacterial infectious disease that results in infection, has material basis in borrelia burgdorferi, which is transmitted by blacklegged tick (ixodes scapularis) or transmitted by western blacklegged tick (ixodes pacificus). the infection has symptom fever, has symptom headache, has symptom fatigue, and has symptom skin rash called erythema migrans. if left untreated, infection can spread to joints, the heart, and the nervous system.

CDC:3 Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected blacklegged ticks. Typical symptoms include fever, headache, fatigue, and a characteristic skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. Lyme disease is diagnosed based on symptoms, physical findings (e.g., rash), and the possibility of exposure to infected ticks; laboratory testing is helpful if used correctly and performed with validated methods. Most cases of Lyme disease can be treated successfully with a few weeks of antibiotics. Steps to prevent Lyme disease include using insect repellent, removing ticks promptly, applying pesticides, and reducing tick habitat. The ticks that transmit Lyme disease can occasionally transmit other tickborne diseases as well.

Wikipedia:63 Lyme disease (Lyme borreliosis) is an infectious disease caused by at least three species of bacteria... more...

Aliases & Classifications for Lyme Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
lyme disease:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

lyme disease 8 10 44 48 33 60
lyme neuroborreliosis 8 44 60
neuroborreliosis 8 60
lyme borreliosis 8 48
neurological lyme disease 8
bannworth's syndrome 8
bannwarth syndrome 8


External Ids:

Disease Ontology8 DOID:11729
NCIt39 C45161
ICD9CM27 088.81
MeSH34 D008193
MESH via Orphanet35 D008193
ICD10 via Orphanet26 A69.2
SNOMED-CT via Orphanet57 23502006
UMLS via Orphanet61 C0024198
ICD1025 A69.2

Related Diseases for Lyme Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lyme Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia30.5CFH, NFE2, CD40LG
2arthritis30.5HSPA8, CCL3, TLR2, CLDN11, LACTB, CIITA
3encephalitis30.3TLR2, CCL3, CCL4, MBP, TPPP3, CIITA
4hepatitis30.1TLR2, CD40LG
5optic neuritis30.1MBP
6neuritis30.1CCL4, MBP, CIITA
7meningitis30.1CCL4, LACTB, TLR2
8amyotrophic lateral sclerosis30.1GPR162
9multiple sclerosis30.1TPPP3, CLDN11, MBP, CIITA, CCL3, HSPA8
10tuberculosis30.1HSPA8, CCL4, MBP, CIITA, LACTB, CCL3
11vasculitis30.1CD40LG
12toxoplasmosis29.9CD40LG
13uveitis29.9CCL4
14lupus erythematosus29.9TLR7, CD40LG
15otitis media29.9TLR2, LACTB
16glomerulonephritis29.9CFH, CCL4, CD40LG
17systemic lupus erythematosus29.9CFH, CD40LG, CCL4, CIITA, TLR7, TLR2
18tropical spastic paraparesis29.9MBP, CCL3
19dementia29.8TPPP3
20encephalomyelitis29.8CLDN11, MBP, CCL3, CIITA, CCL4
21rheumatoid arthritis29.8HSPA8, CCL4, CIITA, CCL3, TLR2, CD40LG
22ehrlichiosis10.6
23babesiosis10.5
24relapsing fever10.5
25nervous system disease10.4
26spotted fever10.4
27human granulocytic anaplasmosis10.3
28rocky mountain spotted fever10.3
29lyme disease - neurological complications10.3
30retinal vasculitis10.3
31myelitis10.3
32pseudotumor cerebri10.3
33sensorineural hearing loss10.3
34neuropathy10.3
35syphilis10.3
36neurologic diseases10.3
37acrodermatitis10.2
38skin disease10.2
39neuroretinitis10.2
40choroiditis10.2
41brain disease10.2
42central nervous system disease10.2
43cerebellar ataxia10.2
44cerebellar disease10.2
45choroid disease10.2
46eye disease10.2
47orbital disease10.2
48nephropathia epidemica10.1
49nonparalytic poliomyelitis10.1
50c3 deficiency10.1

Graphical network of the top 20 diseases related to Lyme Disease:



Diseases related to lyme disease

Clinical Features for Lyme Disease

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48Orphanet
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Symptoms:

48 (show all 32)
  • articular/joint pain/arthralgia
  • fever/chilling
  • asthenia/fatigue/weakness
  • fever
  • headache
  • fatigue
  • skin rash called erythema migrans
  • hydrarthrosis/articular/joint effusion
  • myalgia/muscular pain
  • muscle weakness/flaccidity
  • skin hypoplasia/aplasia/atrophy
  • photophobia
  • transient amaurosis/acute visual trouble
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • arthritis/synovitis/synovial proliferation
  • meningitis/meningeal syndrome
  • cranial nerves palsy
  • follicular/erythematous/edematous papules/milium
  • macules
  • cutaneous rash
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • psychic/behavioural troubles
  • troubles of memory/amnesia/hypermnesia
  • insomnia
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • encephalitis
  • facial pain/cephalalgia/migraine
  • peripheral neuropathy
  • cardiac conduction defect/sinoauricular/heart/auriculoventricular/branch block
  • cardiac rhythm disorder/arrhythmia
  • erythema/erythematous lesions/erythroderma/polymorphous erythema

Drugs & Therapeutics for Lyme Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lyme Disease

Drug clinical trials:

Search ClinicalTrials for Lyme Disease

Search NIH Clinical Center for Lyme Disease

Search CenterWatch for Lyme Disease

Genetic Tests for Lyme Disease

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Anatomical Context for Lyme Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Lyme Disease:

32
Skin, Testes, Heart, Eye, Brain, T cells, Endothelial, B cells, Whole blood, Retina, Spinal cord, Kidney, Liver, Salivary gland, Breast

Animal Models for Lyme Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Lyme Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.9TLR2, TLR7, MBP, CIITA, NFE2, MAFK
2MP:00053879.5CFH, CCL3, TLR2, TLR7, TLR1, MBP

Publications for Lyme Disease

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Sources:
50PubMed
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Articles related to Lyme Disease:

(show top 50)    (show all 637)
idTitleAuthorsYear
1
Elevated Levels of IL-23 in a Subset of Patients With Post-Lyme Disease Symptoms Following Erythema Migrans. (24218102)
2014
2
Lyme Disease -Induced Polyradiculopathy Mimicking Amyotrophic Lateral Sclerosis. (24397499)
2014
3
Lyme disease vaccination: safety first - Author's reply. (24355030)
2014
4
Experience of Lyme disease and preferences for precautions: a cross-sectional survey of UK patients. (23679931)
2013
5
Evaluation of RevA, a fibronectin-binding protein of Borrelia burgdorferi, as a potential vaccine candidate for lyme disease. (23595502)
2013
6
Borrelia burgdorferi infection and Lyme disease in children. (23141587)
2013
7
Neuropsychiatric presentation of Lyme disease in Australia. (23015751)
2013
8
Reinfection versus relapse in Lyme disease. (23484838)
2013
9
Post-treatment Lyme disease syndrome symptomatology and the impact on life functioning: is there something here? (22294245)
2013
10
Using risk group profiles as a lightweight qualitative approach for intervention development: an example of prevention of tick bites and lyme disease. (24172875)
2013
11
Epidemiological and clinical features of three clustered cases co-infected with lyme disease and rickettsioses. (23280084)
2013
12
Assessment of New Culture Method to Detect Borrelia species in Serum of Lyme Disease Patients. (23946519)
2013
13
Lyme disease. (22608120)
2012
14
Diagnosis and management of Lyme disease. (22962880)
2012
15
Evaluation of skin thickness lesions in patients with Lyme disease measured by modified Rodnan total skin score. (21960047)
2012
16
Long term antibiotic therapy may be an effective treatment for children co-morbid with Lyme disease and autism spectrum disorder. (22361005)
2012
17
DipA, a pore-forming protein in the outer membrane of Lyme disease spirochetes exhibits specificity for the permeation of dicarboxylates. (22590556)
2012
18
Lyme disease-like illnesses in the south. (22712174)
2012
19
The rise and fall of the lyme disease vaccines: a cautionary tale for risk interventions in American medicine and public health. (22709388)
2012
20
Bilateral sensorineural hearing loss and cerebellar ataxia in the case of late stage Lyme disease. (23306581)
2012
21
Cerebrospinal fluid proteome of patients with acute Lyme disease. (22900834)
2012
22
Advice for patients. Lyme disease in children and adolescents. (21199990)
2011
23
Treatment for a 14-year-old girl with Lyme disease using therapeutic exercise and gait training. (21737523)
2011
24
Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation. (21947773)
2011
25
Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticks. (21738477)
2011
26
Molecular and pharmacological characterization of two D(1)-like dopamine receptors in the Lyme disease vector, Ixodes scapularis. (21457782)
2011
27
Long-term Lyme disease antibiotic therapy beliefs among New England residents. (21417921)
2011
28
Erythema migrans in Lyme disease. (21624904)
2011
29
Post-Lyme disease symptoms. (20670705)
2010
30
Long-term outcomes in patients with early lyme disease: more false hope? (20482263)
2010
31
Chemoenzymatic synthesis of a glycolipid library and elucidation of the antigenic epitope for construction of a vaccine against Lyme disease. (20143357)
2010
32
The borrelial fibronectin-binding protein RevA is an early antigen of human Lyme disease. (20032216)
2010
33
Community ecology and disease risk: lizards, squirrels, and the Lyme disease spirochete in California, USA. (20380218)
2010
34
NerveCenter: Guideline-making gets tougher: action by state attorney general over Lyme disease guidelines stirs debate. (19334071)
2009
35
A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi. (19218460)
2009
36
Pruritus in latent Lyme disease. (19708331)
2009
37
Biodiversity and Lyme disease: dilution or amplification? (21352766)
2009
38
The antibiotics doxycycline and minocycline inhibit the inflammatory responses to the Lyme disease spirochete Borrelia burgdorferi. (19301981)
2009
39
Lyme disease serology in amyotrophic lateral sclerosis. (19697382)
2009
40
Coronary aneurysm in Lyme Disease: treatment by covered stent. (17692941)
2008
41
Bilateral retrobulbar optic neuritis as first signs of Lyme disease. (18669236)
2008
42
Dacryoadenitis and orbital myositis associated with lyme disease. (18695120)
2008
43
C-terminal region of outer surface protein C binds borreliacidal antibodies in sera from patients with Lyme disease. (12853388)
2003
44
Holmes-Adie syndrome and Lyme disease. (11254002)
2001
45
Gamma interferon is not required for arthritis resistance in the murine Lyme disease model. (11349038)
2001
46
Enzyme-linked immunosorbent assay using recombinant OspC and the internal 14-kDa flagellin fragment for serodiagnosis of early Lyme disease. (9542898)
1998
47
Distribution of Ixodes pacificus and Ixodes scapularis re concurrent babesiosis and Lyme disease. (9704540)
1998
48
Simultaneous expression of Borrelia OspA and OspC and IgM response in cerebrospinal fluid in early neurologic Lyme disease. (9259573)
1997
49
False-positive Lyme disease serology in human granulocytic ehrlichiosis. (8598802)
1996
50
Selected tickborne infections. A review of Lyme disease, Rocky Mountain spotted fever, and babesiosis. (2662061)
1989

Genetic Variations for Lyme Disease

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Expression for genes affiliated with Lyme Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lyme Disease

Search GEO for disease gene expression data for Lyme Disease.

Pathways for genes affiliated with Lyme Disease

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Sources:
52R&D Systems, 4Cell Signaling Technology, 53Reactome, 59Tocris Bioscience, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 55SinoBiological, 29KEGG
See all sources

Pathways related to Lyme Disease according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4TLR1, TLR7
210.3TLR1, TLR7, TLR2
3
Hide members
10.3TLR1, TLR7, TLR2
410.3TLR1, TLR7, TLR2
510.3TLR2, TLR7, TLR1
610.3TLR2, TLR7, TLR1
7
Hide members
10.3TLR2, TLR7, TLR1
8
Hide members
10.3TLR2, TLR7, TLR1, CD40LG
9
Hide members
10.3CD40LG, CIITA, TLR2, HSPA8
10
Hide members
10.2CIITA, TLR7, TLR2, HSPA8
11
Hide members
10.2TLR1, TLR7, TLR2, CCL3, CCL4
12
Hide members
10.2CCL4, CCL3, TLR2, TLR7, TLR1

Compounds for genes affiliated with Lyme Disease

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
See all sources

Compounds related to Lyme Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.8TLR2
2endotoxin4410.8CIITA, HSPA8
3pam2csk45910.7TLR2, TLR7, TLR1
4pam3csk45910.7TLR2, TLR7, TLR1
5poly(i:c)5910.7TLR2, TLR7, TLR1
6resiquimod44 5911.7TLR1, TLR7, TLR2
7loxoribine44 2811.7TLR7, TLR2
8imiquimod44 28 59 1113.7TLR1, TLR7, TLR2
9glucuronoxylomannan4410.7TLR2, CD40LG
10toxin-14410.7CCL4, CCL3, CIITA
11mdms4410.7CCL4, CCL3, CIITA
12lipoteichoic acid4410.7CCL3, TLR2, TLR7, TLR1
13indomethacin44 59 28 1113.7MBP
14polyinosinic-polycytidylic acid4410.7CCL3, TLR2, TLR7, CIITA
15poly(i-c)4410.7CCL3, TLR2, TLR7
16allergens4410.7CD40LG, CIITA, CCL4, HSPA8
17tacrolimus44 49 1112.6TLR2, CCL3, CCL4
18il 104410.6CCL4, CCL3, TLR2
19ivig4410.6CCL4, MBP, CD40LG
20cefotaxime44 1111.6LACTB, TLR2
21dexamethasone44 49 28 1113.6CFH, CD40LG, CIITA, TLR2
22ccl344 2811.6TLR2, CCL3, CCL4
23ionomycin4410.6CCL4, CCL3, TLR2, CD40LG
24heparin44 28 11 2413.6HSPA8, CCL4, CCL3, CD40LG, CFHR1
25ccl444 2811.6TLR2, CCL3, CCL4
26vancomycin44 1111.6LACTB, CD40LG
27ganglioside4410.6CD40LG, CIITA, MBP
28simvastatin44 49 59 28 11 2415.6HSPA8, CCL4, CCL3, TLR2, CIITA
29pneumococcal4410.6CD40LG, CFH
30polysaccharide4410.6CCL4, CCL3, TLR2, CD40LG, CFH
31isopentenyl diphosphate44 2811.6CCL4, CCL3
32rantes4410.6HSPA8, CCL4, CCL3, TLR2, CIITA, CD40LG
33actinomycin d4410.5CCL3, TLR2, CIITA, NFE2, CD40LG
34hydroxychloroquine44 1111.5CD40LG, TLR7
35ribonucleic acid4410.5HSPA8, CCL3, TLR2, CIITA
36peptidoglycan44 2811.5CIITA, HSPA8, CCL4, CCL3, TLR2, TLR7
37serine4410.5HSPA8, CCL4, CCL3, TLR2, CIITA, LACTB
38cholesterol44 28 11 2413.5HSPA8, CCL4, CCL3, TLR2, CIITA, CFH
39teck4410.5CCL3, CCL4
40leucine4410.4CCL3, TLR2, CIITA, NFE2, MAFK
41cyclosporin a44 28 5912.4HSPA8, CCL4, CCL3, TLR2, MBP, CIITA
42alanine4410.4HSPA8, CCL4, CCL3, TLR2, MBP, CIITA
43mcp 14410.4CCL4, CCL3
44cysteine4410.4HSPA8, CCL4, CCL3, TLR2, MBP, CIITA
45retinoic acid44 2411.4CFH, CCL4, CCL3, TLR2, MBP, CD40LG
46histamine44 28 2412.3CCL4, CCL3, TLR2, CD40LG
472,3-cyclic nucleotide4410.3MBP, CLDN11
48amoxicillin44 49 1112.3CD40LG, LACTB
49steroid4410.1CCL4, CCL3, CIITA, NFE2, HSPA8
50mip 1alpha4410.0CCL3, CCL4

GO Terms for genes affiliated with Lyme Disease

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Sources:
16Gene Ontology
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Cellular components related to Lyme Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.4TLR1, TLR2

Biological processes related to Lyme Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cellular response to triacyl bacterial lipopeptideGO:07172710.6TLR2, TLR1
2detection of triacyl bacterial lipopeptideGO:04249510.6TLR2, TLR1
3detection of diacyl bacterial lipopeptideGO:04249610.6TLR1, TLR2
4positive regulation of natural killer cell chemotaxisGO:200050310.5CCL3, CCL4
5positive regulation of inflammatory responseGO:05072910.5CCL3, TLR2, TLR7
6axon ensheathmentGO:00836610.5CLDN11, MBP
7positive regulation of tumor necrosis factor biosynthetic processGO:04253510.4TLR2, TLR1
8inflammatory responseGO:00695410.4CD40LG, TLR1, TLR7, TLR2, CCL3, CCL4
9response to toxic substanceGO:00963610.4MBP, CCL3, CCL4
10I-kappaB phosphorylationGO:00725210.4TLR7, TLR2
11positive regulation of chemokine productionGO:03272210.4TLR7, TLR2
12immune responseGO:00695510.4CCL4, TLR2, TLR1, MBP, CIITA, SP2
13negative regulation by host of viral transcriptionGO:04392210.2CCL3, CCL4
14negative regulation of bone mineralizationGO:03050210.0NFE2, CCL3

Molecular functions related to Lyme Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR1 chemokine receptor bindingGO:03172610.3CCL3, CCL4
2CCR5 chemokine receptor bindingGO:03173010.0CCL3, CCL4

Products for genes affiliated with Lyme Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lyme Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet