MCID: LYM017
MIFTS: 56

Lyme Disease malady

Infectious diseases, Neuronal diseases, Rare diseases categories

Aliases & Classifications for Lyme Disease

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 32MedlinePlus, 3CDC, 60UMLS, 33MeSH, 27ICD9CM, 55SNOMED-CT, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Lyme Disease, Aliases & Descriptions:

Name: Lyme Disease 9 11 43 47 32 3 60
Lyme Neuroborreliosis 9 43 60
Neuroborreliosis 9 60
Lyme Borreliosis 9 47
 
Neurological Lyme Disease 9
Bannworth's Syndrome 9
Bannwarth Syndrome 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
lyme disease:
Inheritance: Not applicable; Prevalence: >1/1000 (Europe),1-5/10000 (France); Age of onset: All ages


External Ids:

Disease Ontology9 DOID:11729
MeSH33 D008193
ICD9CM27 088.81
NCIt38 C45161
Orphanet47 91546
MESH via Orphanet34 D008193
ICD10 via Orphanet26 A69.2
UMLS via Orphanet61 C0024198
ICD1025 A69.2

Summaries for Lyme Disease

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MedlinePlus:32 Lyme disease is a bacterial infection you get from the bite of an infected tick. the first symptom is usually a rash, which may look like a bull's eye. as the infection spreads, you may have a fever a headache muscle and joint aches a stiff neck fatigue lyme disease can be hard to diagnose because you may not have noticed a tick bite. also, many of its symptoms are like those of the flu and other diseases. in the early stages, your health care provider will look at your symptoms and medical history, to figure out whether you have lyme disease. lab tests may help at this stage, but may not always give a clear answer. in the later stages of the disease, a different lab test can confirm whether you have it. antibiotics can cure most cases of lyme disease. the sooner treatment begins, the quicker and more complete the recovery. after treatment, some patients may still have muscle or joint aches and nervous system symptoms. this is called post-lyme disease syndrome (plds). long-term antibiotics have not been shown to help with plds. however, there are ways to help with the symptoms of plds, and most patients do get better with time. nih: national institute of allergy and infectious diseases

MalaCards based summary: Lyme Disease, also known as lyme neuroborreliosis, is related to thrombocytopenia and scrub typhus, and has symptoms including hypermelanotic macule, meningitis and arthritis. An important gene associated with Lyme Disease is CD40LG (CD40 ligand), and among its related pathways are Malaria and Th17 Differentiation. The compounds pneumococcal and silicone have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and testes, and related mouse phenotypes are other and immune system.

Disease Ontology:9 A primary bacterial infectious disease that results in infection, has material basis in borrelia burgdorferi, which is transmitted by blacklegged tick (ixodes scapularis) or transmitted by western blacklegged tick (ixodes pacificus). the infection has symptom fever, has symptom headache, has symptom fatigue, and has symptom skin rash called erythema migrans. if left untreated, infection can spread to joints, the heart, and the nervous system.

CDC:3 To receive email updates about this page, enter your email address:

Wikipedia:63 Lyme disease, also known as Lyme borreliosis, is an infectious disease caused by bacteria of the... more...

Related Diseases for Lyme Disease

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Graphical network of the top 20 diseases related to Lyme Disease:



Diseases related to lyme disease

Symptoms for Lyme Disease

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Symptoms:

 47 9 (show all 32)
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • follicular/erythematous/edematous papules/milium
  • cranial nerves palsy
  • meningitis/meningeal syndrome
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • transient amaurosis/acute visual trouble
  • photophobia
  • skin hypoplasia/aplasia/atrophy
  • cutaneous rash
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • cardiac rhythm disorder/arrhythmia
  • cardiac conduction defect/sinoauricular/heart/auriculoventricular/branch block
  • peripheral neuropathy
  • facial pain/cephalalgia/migraine
  • encephalitis
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • insomnia
  • troubles of memory/amnesia/hypermnesia
  • psychic/behavioural troubles
  • muscle weakness/flaccidity
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • fever/chilling
  • asthenia/fatigue/weakness
  • fever
  • headache
  • fatigue
  • skin rash called erythema migrans

HPO human phenotypes related to Lyme Disease:

(show all 21)
id Description Frequency HPO Source Accession
1 hypermelanotic macule hallmark (90%) HP:0001034
2 meningitis typical (50%) HP:0001287
3 arthritis typical (50%) HP:0001369
4 joint swelling typical (50%) HP:0001386
5 cranial nerve paralysis typical (50%) HP:0006824
6 photophobia occasional (7.5%) HP:0000613
7 skin rash occasional (7.5%) HP:0000988
8 muscle weakness occasional (7.5%) HP:0001324
9 nausea and vomiting occasional (7.5%) HP:0002017
10 migraine occasional (7.5%) HP:0002076
11 memory impairment occasional (7.5%) HP:0002354
12 encephalitis occasional (7.5%) HP:0002383
13 arthralgia occasional (7.5%) HP:0002829
14 myalgia occasional (7.5%) HP:0003326
15 paresthesia occasional (7.5%) HP:0003401
16 abnormality of temperature regulation occasional (7.5%) HP:0004370
17 aplasia/hypoplasia of the skin occasional (7.5%) HP:0008065
18 arrhythmia occasional (7.5%) HP:0011675
19 inflammatory abnormality of the eye occasional (7.5%) HP:0100533
20 amaurosis fugax occasional (7.5%) HP:0100576
21 insomnia occasional (7.5%) HP:0100785

Drugs & Therapeutics for Lyme Disease

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Drug clinical trials:

Search ClinicalTrials for Lyme Disease

Search NIH Clinical Center for Lyme Disease

Genetic Tests for Lyme Disease

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Anatomical Context for Lyme Disease

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MalaCards organs/tissues related to Lyme Disease:

31
Heart, Skin, Testes, Eye, Brain, T cells, Endothelial, B cells, Whole blood, Retina, Spinal cord, Kidney, Liver, Salivary gland, Breast

Animal Models for Lyme Disease or affiliated genes

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MGI Mouse Phenotypes related to Lyme Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.9CD40LG, CFH, TLR2
2MP:00053877.7CD40LG, CIITA, CFH, TLR1, TLR2
3MP:00053977.4TLR2, TLR1, CFH, CIITA, CD40LG

Publications for Lyme Disease

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Articles related to Lyme Disease:

(show top 50)    (show all 670)
idTitleAuthorsYear
1
Popliteal cyst with positive antinuclear antibodies as the presentation of lyme disease. (25876095)
2015
2
Anti-neural antibody response in patients with post-treatment Lyme disease symptoms versus those with myalgic encephalomyelitis/chronic fatigue syndrome. (25866194)
2015
3
Integrated assessment of behavioral and environmental risk factors for lyme disease infection on block island, rhode island. (24416278)
2014
4
Provider Knowledge, Attitudes, and Practices Regarding Lyme Disease in Arkansas. (25187225)
2014
5
Post-infectious glomerulonephritis presenting as acute renal failure in a patient with Lyme disease. (25340158)
2014
6
Increased IFNI+ activity and differential antibody response in patients with a history of Lyme disease and persistent cognitive deficits. (23141748)
2013
7
Distribution of cp32 prophages among Lyme disease-causing spirochetes and natural diversity of their lipoprotein-encoding erp loci. (23624478)
2013
8
Potential role of deer tick virus in Powassan encephalitis cases in Lyme disease-endemic areas of New York, U.S.A. (24274334)
2013
9
Multi-criteria decision analysis as an innovative approach to managing zoonoses: results from a study on Lyme disease in Canada. (24079303)
2013
10
The Lyme disease debate: host biodiversity and human disease risk. (23548684)
2013
11
Experience of Lyme disease and preferences for precautions: a cross-sectional survey of UK patients. (23679931)
2013
12
Reductions in human Lyme disease risk due to the effects of oral vaccination on tick-to-mouse and mouse-to-tick transmission. (23428088)
2013
13
Bull's eye! Lyme disease awareness. (24137697)
2013
14
Lyme disease--unusual medical encounter for an urologist. (23700896)
2012
15
What do we need to know about disease ecology to prevent Lyme disease in the northeastern United States? (22308766)
2012
16
A single-domain FlgJ contributes to flagellar hook and filament formation in the Lyme disease spirochete Borrelia burgdorferi. (22155773)
2012
17
Lyme disease: knowledge, beliefs, and practices of physicians in a low-endemic area. (22734172)
2012
18
Neurogenic bladder in lyme disease. (23346488)
2012
19
Lyme disease. (22608120)
2012
20
Lyme disease presenting as ptosis, conjunctivitis, and photophobia. (21224251)
2012
21
Diagnosis and management of Lyme disease. (22962880)
2012
22
Advice for patients. Lyme disease in children and adolescents. (21199990)
2011
23
Canine serology as adjunct to human Lyme disease surveillance. (21888800)
2011
24
Lyme disease enolpyruvyl-UDP-GlcNAc synthase: fosfomycin-resistant MurA from Borrelia burgdorferi, a fosfomycin-sensitive mutant, and the catalytic role of the active site Asp. (21294548)
2011
25
Pervasive recombination and sympatric genome diversification driven by frequency-dependent selection in Borrelia burgdorferi, the Lyme disease bacterium. (21890743)
2011
26
The pain of chronic Lyme disease: moving the discourse backward? (22131364)
2011
27
Trial of a minimal-risk botanical compound to control the vector tick of Lyme disease. (20695287)
2010
28
Invasion of the lyme disease vector Ixodes scapularis: implications for Borrelia burgdorferi endemicity. (20229127)
2010
29
Recent discovery of widespread Ixodes affinis (Acari: Ixodidae) distribution in North Carolina with implications for Lyme disease studies. (20618664)
2010
30
The utility of "Google Trends" for epidemiological research: Lyme disease as an example. (20503183)
2010
31
The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete. (19906179)
2009
32
Hosts as ecological traps for the vector of Lyme disease. (19692412)
2009
33
Successful desensitisation to ceftriaxone in a patient with doxycicline resistant Lyme disease. (19445868)
2009
34
NerveCenter: Guideline-making gets tougher: action by state attorney general over Lyme disease guidelines stirs debate. (19334071)
2009
35
Complement split products c3a and c4a in chronic lyme disease. (19140878)
2009
36
Community-based prevention of Lyme disease and other tick-borne diseases through topical application of acaricide to white-tailed deer: background and rationale. (19650729)
2009
37
A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi. (19218460)
2009
38
Significantly improved accuracy of diagnosis of early Lyme disease by peptide enzyme-linked immunosorbent assay based on the borreliacidal antibody epitope of Borrelia burgdorferi OspC. (18417666)
2008
39
IgE anti-Borrelia burgdorferi components (p18, p31, p34, p41, p45, p60) and increased blood CD8+CD60+ T cells in children with Lyme disease. (17386029)
2007
40
Differential binding of host complement inhibitor factor H by Borrelia burgdorferi Erp surface proteins: a possible mechanism underlying the expansive host range of Lyme disease spirochetes. (11796574)
2002
41
Atypical erythema multiforme occurring at the early phase of Lyme disease? (10954224)
2000
42
Carbamazepine in the treatment of Lyme disease-induced hyperacusis. (9990563)
1999
43
Recurrent human granulocytic ehrlichiosis and Lyme disease. (10383360)
1999
44
Lyme disease and human granulocytic ehrlichiosis. (9322603)
1997
45
A monoclonal antibody to Borrelia burgdorferi flagellin modifies neuroblastoma cell neuritogenesis in vitro: a possible role for autoimmunity in the neuropathy of Lyme disease. (9125553)
1997
46
Uptake and killing of Lyme disease and relapsing fever borreliae in the perfused rat liver and by isolated Kupffer cells. (8613404)
1996
47
Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. (8551229)
1996
48
Establishment of enzyme-linked immunosorbent assay using purified recombinant 83-kilodalton antigen of Borrelia burgdorferi sensu stricto and Borrelia afzelii for serodiagnosis of Lyme disease. (8567889)
1995
49
Immune recognition of human Hsp60 by Lyme disease patient sera. (8100982)
1993
50
Iritis and papillitis as a primary presentation of Lyme disease. (2310116)
1990

Variations for Lyme Disease

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Expression for genes affiliated with Lyme Disease

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Search GEO for disease gene expression data for Lyme Disease.

Pathways for genes affiliated with Lyme Disease

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Pathways related to Lyme Disease according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TLR2, CD40LG
2
Show member pathways
9.4TLR2, TLR1
39.4TLR1, TLR2
4
Show member pathways
9.4TLR1, TLR2
59.4TLR1, TLR2
6
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.4TLR2, TLR1
7
Show member pathways
IL27-mediated signaling events36
9.4TLR2, TLR1
8
Show member pathways
9.4TLR1, TLR2
99.3TLR2, HSPA8
109.3CD40LG, CIITA
11
Show member pathways
9.0CD40LG, TLR1, TLR2
12
Show member pathways
8.8CD40LG, HSPA8, CIITA
138.6CIITA, TLR1, TLR2
14
Show member pathways
8.5CIITA, HSPA8, TLR2
15
Show member pathways
8.1CIITA, TLR2, HSPA8, CD40LG

Compounds for genes affiliated with Lyme Disease

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Compounds related to Lyme Disease according to GeneCards Suite gene sharing:

(show all 45)
idCompoundScoreTop Affiliating Genes
1pneumococcal4310.0CFH, CD40LG
2silicone439.9HSPA8, CD40LG
3glucuronoxylomannan439.9CD40LG, TLR2
4cardiolipin43 1210.9CFH, CD40LG
5mannan439.8TLR2, CD40LG
6pam3csk4599.8TLR1, TLR2
7poly(i:c)599.8TLR2, TLR1
8pam2csk4599.8TLR2, TLR1
9resiquimod43 5910.8TLR2, TLR1
10flagellin43 2810.8TLR1, TLR2
11imiquimod43 59 28 1212.8TLR1, TLR2
12lipoteichoic acid439.7TLR2, TLR1
13anti-fungal439.7TLR2, CD40LG
14theophylline43 28 24 1212.7CD40LG, HSPA8
15mannitol43 1210.5CD40LG, HSPA8
16dextran sulfate439.5CD40LG, CIITA
17enterotoxin439.4TLR2, CIITA
18ganglioside439.3CIITA, CD40LG
19deoxyribonucleic acid439.3CIITA, HSPA8
20polyinosinic-polycytidylic acid439.3CIITA, TLR2
21polysaccharide439.3CD40LG, TLR2, CFH
22fibrinogen439.3CD40LG, CFH, TLR2
23cisplatin43 49 59 1212.2CD40LG, HSPA8, CFH
24allergens439.2HSPA8, CIITA, CD40LG
25heparin43 28 24 1212.1CD40LG, HSPA8, CFHR1, CFH
26dopamine43 28 24 1212.0CIITA, CD40LG, HSPA8
27actinomycin d439.0CIITA, TLR2, CD40LG
28simvastatin43 49 59 28 24 1213.9HSPA8, CIITA, TLR2
29ribonucleic acid438.9TLR2, HSPA8, CIITA
30hydrogen43 249.8TLR2, HSPA8, CIITA
31vegf438.7CD40LG, TLR2, HSPA8
32zinc43 249.6CIITA, HSPA8, CFH
33endotoxin438.6HSPA8, CD40LG, CIITA, TLR2
34rantes438.6TLR2, CIITA, CD40LG, HSPA8
35pge2438.6CIITA, TLR2, HSPA8, CD40LG
36dexamethasone43 49 28 1211.5CD40LG, TLR2, CFH, CIITA
37peptidoglycan43 289.5HSPA8, CIITA, TLR1, TLR2
38cholesterol43 28 24 1211.4CFH, HSPA8, CIITA, TLR2
39glucose438.3TLR2, CIITA, HSPA8, CFH
40lipid438.3CIITA, HSPA8, TLR2, TLR1
41cyclosporin a43 28 5910.1TLR2, CFH, HSPA8, CIITA, CD40LG
42alanine438.0TLR2, CFH, HSPA8, CIITA, CD40LG
43cysteine438.0TLR2, CFH, HSPA8, CIITA, CD40LG
44serine438.0HSPA8, CIITA, TLR2, CD40LG, CFH
45tyrosine438.0HSPA8, TLR2, CIITA, CFH

GO Terms for genes affiliated with Lyme Disease

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Cellular components related to Lyme Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:00353549.1TLR1, TLR2
2blood microparticleGO:00725629.0HSPA8, CFHR1, CFH

Biological processes related to Lyme Disease according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cellular response to triacyl bacterial lipopeptideGO:00717279.6TLR2, TLR1
2detection of triacyl bacterial lipopeptideGO:00424959.5TLR2, TLR1
3positive regulation of interleukin-12 productionGO:00327359.5TLR2, CD40LG
4positive regulation of tumor necrosis factor biosynthetic processGO:00425359.5TLR2, TLR1
5complement activationGO:00069569.4CFH, CFHR1
6toll-like receptor signaling pathwayGO:00022249.4TLR2, TLR1
7innate immune responseGO:00450878.6TLR2, TLR1, CFH
8immune responseGO:00069558.6TLR2, TLR1, CIITA
9inflammatory responseGO:00069548.4TLR2, TLR1, CIITA, CD40LG

Molecular functions related to Lyme Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00048889.4TLR1, TLR2

Products for genes affiliated with Lyme Disease

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  • Antibodies
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  • Antibodies
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Sources for Lyme Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet