MCID: LYM017
MIFTS: 68

Lyme Disease

Categories: Rare diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Lyme Disease

MalaCards integrated aliases for Lyme Disease:

Name: Lyme Disease 12 72 49 55 51 40 3 41 14 69
Lyme Neuroborreliosis 12 51 41 69
Lyme Borreliosis 12 49 55
Neuroborreliosis 12 69
Borreliosis 49 51
Neurological Lyme Disease 12
Bannworth's Syndrome 12
Borrelia Infections 69
Bannwarth Syndrome 12
Lym 72

Characteristics:

Orphanet epidemiological data:

55
lyme disease
Inheritance: Not applicable; Prevalence: >1/1000 (Europe),1-5/10000 (France); Age of onset: All ages;

Classifications:



Summaries for Lyme Disease

MedlinePlus : 40 Lyme disease is a bacterial infection you get from the bite of an infected tick. The first symptom is usually a red rash, which may look like a bull's eye. But not all people with Lyme disease have a rash. As the infection spreads to other parts of the body, you may have A fever A headache Body aches A stiff neck Fatigue Lyme disease can be hard to diagnose because many of its symptoms are like those of the flu and other diseases. And you may not have noticed a tick bite. Your health care provider will look at your symptoms and medical history to figure out whether you have Lyme disease. Lab tests may not always give a clear answer until you have been infected for at least a few weeks. Antibiotics can cure most cases of Lyme disease. The sooner treatment begins, the quicker and more complete the recovery. After treatment, some patients may still have muscle or joint aches and nervous system symptoms. This is called post-treatment Lyme disease syndrome (PTLDS). Long-term antibiotics have not been shown to help with PTLDS. However, there are ways to help with the symptoms of PTLDS, and most patients do get better with time. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Lyme Disease, also known as lyme neuroborreliosis, is related to relapsing fever and choroiditis, and has symptoms including fever, headache and fatigue. An important gene associated with Lyme Disease is YBX3 (Y-Box Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ceftriaxone and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and testes, and related phenotypes are hematopoietic system and endocrine/exocrine gland

NIH Rare Diseases : 49 Lyme disease is the most common tickborne infectious disease in the United States. Early signs and symptoms of the condition include fever, chills, muscle pain, headache, and joint pain. As the condition progresses, affected people may experience heart problems, Bell's palsy, arthritis, abnormal muscle movement, speech problems and cognitive (thinking) abnormalities. Please visit the Center for Disease Control and Prevention's Web site for a more comprehensive list of symptoms. Lyme disease is caused by the bacterium Borrelia burgdorferi, which is transmitted to humans through the bite of infected blacklegged ticks. Certain features of the condition, including whether or not an affected person will develop medication-resistant chronic arthritis, is thought to be influenced by genetic factors (certain human leukocyte antigen genes). Treatment generally includes antibiotics to address the bacterial infection and other medications (i.e. pain medications) to relieve symptoms. Last updated: 10/6/2015

CDC : 3 Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected blacklegged ticks. Typical symptoms include fever, headache, fatigue, and a characteristic skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. Lyme disease is diagnosed based on symptoms, physical findings (e.g., rash), and the possibility of exposure to infected ticks.  Laboratory testing is helpful if used correctly and performed with validated methods. Most cases of Lyme disease can be treated successfully with a few weeks of antibiotics. Steps to prevent Lyme disease include using insect repellent, removing ticks promptly, applying pesticides, and reducing tick habitat. The ticks that transmit Lyme disease can occasionally transmit other tickborne diseases as well.

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection, has material basis in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has symptom fever, has symptom headache, has symptom fatigue, and has symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.

Wikipedia : 72 Lyme disease, also known as Lyme borreliosis, is an infectious disease caused by bacteria of the... more...

Related Diseases for Lyme Disease

Diseases related to Lyme Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 377)
# Related Disease Score Top Affiliating Genes
1 relapsing fever 30.5 CFH CRP TNF
2 choroiditis 30.2 CFH TNF
3 cat-scratch disease 30.0 CD40LG HSPD1
4 multifocal choroiditis 29.9 CFH TNF
5 mononeuritis multiplex 29.7 CD40LG CRP
6 glomerulonephritis 29.5 C3 CD40LG CFH IL1B
7 transverse myelitis 29.5 IL17A IL6 TNF
8 myelitis 29.5 IL17A IL6 TNF
9 chronic fatigue syndrome 29.5 IL1B IL6 TNF
10 keratitis, hereditary 29.2 IL17A IL1B TLR2
11 arthritis 29.2 IL17A IL1B IL6 TNF
12 panuveitis 29.0 CD40LG IL17A TNF
13 toxoplasmosis 29.0 CD40LG IL1B IL6 TNF
14 stromal keratitis 29.0 IL17A IL6 TNF
15 spondyloarthropathy 28.9 IL17A IL6 TNF
16 q fever 28.8 CD40LG IL1B TLR1 TLR2 TNF
17 pericarditis 28.8 CRP IL1B IL6 TNF
18 mycobacterium tuberculosis 1 28.8 HSPD1 IL17A TLR1 TLR2 TNF
19 otitis media 28.7 CD40LG IL1B IL6 TLR2 TNF
20 myocarditis 28.7 CD40LG IL17A IL6 TNF
21 neurosyphilis 28.6 IL17A TLR1 TLR2 TLR6
22 scrub typhus 28.5 CD40LG CRP IL1B TLR2 TNF
23 peritonitis 28.5 CRP IL1B IL6 TLR2 TNF
24 meningitis 28.3 CD40LG CRP IL1B IL6 TLR2 TNF
25 psoriatic arthritis 28.3 CRP IL17A IL1B TNF
26 multiple sclerosis 28.3 CLDN11 HSPD1 IL17A IL1B IL6 TNF
27 rheumatoid arthritis 27.2 CD40LG CRP IL17A IL1B IL6 TLR2
28 systemic lupus erythematosus 27.0 C3 CD40LG CRP IL17A IL1B IL6
29 lyme disease - neurological complications 12.4
30 human granulocytic anaplasmosis 11.2
31 babesiosis 11.2
32 powassan encephalitis 11.2
33 tick infestation 11.2
34 pars planitis 10.8
35 atrophoderma of pierini and pasini 10.8
36 autoimmune inner ear disease 10.8
37 idiopathic hypertrophic pachymeningitis 10.8
38 lymphocytic infiltrate of jessner 10.8
39 pseudopelade of brocq 10.8
40 complement factor h deficiency 10.4 CFH CFHR1
41 dense deposit disease 10.4 C3 CFH
42 fallopian tube disease 10.4 CD40LG HSPD1
43 c3 glomerulopathy 10.3 C3 CFHR1
44 scorpion envenomation 10.3 IL6 TNF
45 prosthetic joint infection 10.3 IL1B TLR2
46 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
47 critical limb ischemia 10.3 IL6 TNF
48 encephalitozoonosis 10.3 CD40LG TNF
49 salpingitis 10.3 CD40LG HSPD1
50 bacteriuria 10.3 CD40LG IL6 TLR1

Graphical network of the top 20 diseases related to Lyme Disease:



Diseases related to Lyme Disease

Symptoms & Phenotypes for Lyme Disease

Symptoms:

12
  • fever
  • headache
  • fatigue
  • skin rash called erythema migrans

Human phenotypes related to Lyme Disease:

55 31 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 uveitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0000554
2 photophobia 55 31 occasional (7.5%) Occasional (29-5%) HP:0000613
3 meningitis 55 31 frequent (33%) Frequent (79-30%) HP:0001287
4 muscle weakness 55 31 occasional (7.5%) Occasional (29-5%) HP:0001324
5 arthritis 55 31 frequent (33%) Frequent (79-30%) HP:0001369
6 joint swelling 55 31 frequent (33%) Frequent (79-30%) HP:0001386
7 atrioventricular block 55 31 occasional (7.5%) Occasional (29-5%) HP:0001678
8 fever 55 31 occasional (7.5%) Occasional (29-5%) HP:0001945
9 nausea and vomiting 55 31 occasional (7.5%) Occasional (29-5%) HP:0002017
10 headache 55 31 occasional (7.5%) Occasional (29-5%) HP:0002315
11 memory impairment 55 31 occasional (7.5%) Occasional (29-5%) HP:0002354
12 encephalitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0002383
13 arthralgia 55 31 occasional (7.5%) Occasional (29-5%) HP:0002829
14 myalgia 55 31 occasional (7.5%) Occasional (29-5%) HP:0003326
15 paresthesia 55 31 occasional (7.5%) Occasional (29-5%) HP:0003401
16 dermal atrophy 55 31 occasional (7.5%) Occasional (29-5%) HP:0004334
17 cranial nerve paralysis 55 31 frequent (33%) Frequent (79-30%) HP:0006824
18 arrhythmia 55 31 occasional (7.5%) Occasional (29-5%) HP:0011675
19 fatigue 55 31 occasional (7.5%) Occasional (29-5%) HP:0012378
20 amaurosis fugax 55 31 occasional (7.5%) Occasional (29-5%) HP:0100576
21 insomnia 55 31 occasional (7.5%) Occasional (29-5%) HP:0100785
22 skin nodule 55 31 occasional (7.5%) Occasional (29-5%) HP:0200036
23 behavioral abnormality 55 Occasional (29-5%)
24 peripheral neuropathy 55 Occasional (29-5%)

UMLS symptoms related to Lyme Disease:


pruritus, fever

MGI Mouse Phenotypes related to Lyme Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 IL6 C3 TLR1 TLR2 CD40LG TLR6
2 endocrine/exocrine gland MP:0005379 9.92 IL6 C3 TLR2 CD40LG TNF CLDN11
3 immune system MP:0005387 9.9 C3 TLR1 TLR2 CD40LG TLR6 CFH
4 nervous system MP:0003631 9.65 IL6 C3 TLR2 CD40LG CFH TNF
5 reproductive system MP:0005389 9.23 IL6 C3 CD40LG TLR6 TNF CLDN11

Drugs & Therapeutics for Lyme Disease

Drugs for Lyme Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftriaxone Approved Phase 4,Phase 3,Phase 1,Phase 2 73384-59-5 5479530 5361919
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
3
Clarithromycin Approved Phase 4 81103-11-9 84029
4
Hydroxychloroquine Approved Phase 4 118-42-3 3652
5
Cefuroxime Approved Phase 4 55268-75-2 5479529 5361202
6
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
7
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
8
Azithromycin Approved Phase 4,Phase 1,Phase 2 83905-01-5 53477736 447043 55185
9
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
10 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Antimalarials Phase 4,Phase 3,Phase 2
13 Antiparasitic Agents Phase 4,Phase 3,Phase 2
14 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
15 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
16 Antirheumatic Agents Phase 4
17 Antitubercular Agents Phase 4,Phase 2
18 Cytochrome P-450 CYP3A Inhibitors Phase 4
19 Cytochrome P-450 Enzyme Inhibitors Phase 4
20 cefuroxime axetil Phase 4
21 penicillins Phase 4
22 Erythromycin Estolate Phase 4
23 Erythromycin Ethylsuccinate Phase 4
24 Erythromycin stearate Phase 4
25
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
26
Permethrin Approved, Investigational Phase 3 52645-53-1 40326
27 PENTA Phase 3
28 Vaccines Phase 1, Phase 2
29
Carbon monoxide Approved, Investigational Phase 1 630-08-0 281
30
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
31
Aluminum sulfate Approved Phase 1 10043-01-3
32 Adjuvants, Immunologic Phase 1
33 Antacids Phase 1
34 Anti-Ulcer Agents Phase 1
35 Gastrointestinal Agents Phase 1
36
Didanosine Approved 69655-05-6 50599
37
Lamivudine Approved, Investigational 134678-17-4 60825
38
Lopinavir Approved 192725-17-0 92727
39
Ritonavir Approved, Investigational 155213-67-5 392622
40
Stavudine Approved, Investigational 3056-17-5 18283
41
Zidovudine Approved 30516-87-1 35370
42
Ethanol Approved 64-17-5 702
43
Hydroxocobalamin Approved 13422-51-0 5460373 44475014 11953898
44
Granisetron Approved, Investigational 109889-09-0 3510
45
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
46
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical 13422-55-4
47 Anti-HIV Agents
48 Antimetabolites
49 Anti-Retroviral Agents
50 Antiviral Agents

Interventional clinical trials:

(show top 50) (show all 56)

# Name Status NCT ID Phase Drugs
1 Study of Lyme Neuroborreliosis Unknown status NCT01635530 Phase 4 Doxycycline;Ceftriaxone
2 Persistent Lyme Empiric Antibiotic Study Europe Completed NCT01207739 Phase 4 Doxycycline;Clarithromycin and hydroxychloroquine;Placebo
3 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed NCT01518192 Phase 4 doxycycline;cefuroxime axetil
4 Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice Completed NCT01368341 Phase 4 Doxycycline;Phenoxymethylpenicillin;Amoxicillin
5 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
6 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3 minocycline
7 Study and Treatment of Post Lyme Disease (STOP-LD) Completed NCT00000937 Phase 3 Antibiotics
8 A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seropositive Chronic Lyme Disease Completed NCT00001101 Phase 3 ceftriaxone;doxycycline
9 A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seronegative Chronic Lyme Disease Completed NCT00000938 Phase 3 ceftriaxone;doxycycline
10 Lyme Disease Prevention Program Completed NCT00000432 Phase 3
11 Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever Completed NCT00237016 Phase 2, Phase 3 doxycycline treatment
12 Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis Completed NCT00138801 Phase 3 Ceftriaxone;Doxycycline
13 Six Versus Two Weeks Treatment With Doxycycline in Lyme Neuroborreliosis Enrolling by invitation NCT02553473 Phase 3 Doxycycline;Placebo
14 Passive Prophylaxis of Lyme Disease Using Permethrin Treated Clothes Terminated NCT00958139 Phase 3
15 A Placebo-controlled Efficacy Study of IV Ceftriaxone for Refractory Psychosis Unknown status NCT00591318 Phase 1, Phase 2 ceftriaxone;Normal Saline
16 Brain Imaging and Retreatment Study of Persistent Lyme Disease Completed NCT00037479 Phase 2 ceftriaxone
17 Safety, Skin and Plasma Concentration of Azithromycin Dermal Formulation Completed NCT01243008 Phase 1, Phase 2 Application of SHB001
18 Antibiotic Treatment Trial for the PANDAS/PANS Phenotype Completed NCT01617083 Phase 2 Azithromycin;Placebo
19 Phase 1/2 Lyme Vaccine Study Completed NCT01504347 Phase 1, Phase 2
20 Xenodiagnosis After Antibiotic Treatment for Lyme Disease Recruiting NCT02446626 Phase 1, Phase 2
21 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
22 Study Assessing the Safety, Immunogenicity and Dose Response of VLA15, A New Vaccine Candidate Against Lyme Borreliosis Active, not recruiting NCT03010228 Phase 1
23 Meditation and Stretching for Post Treatment Lyme Disease Syndrome Unknown status NCT02344537
24 A School-Based Intervention to Reduce Lyme Disease Unknown status NCT00594997
25 Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis Unknown status NCT00942006 doxycycline;ceftriaxone
26 Searching for Persistence of Infection in Lyme Disease Completed NCT01143558 Early Phase 1
27 Culture Media for Borrelia Burgdorferi Sensu Lato Completed NCT02145754
28 CD8 Reactivity to Microorganisms in Blood and Breast Milk Completed NCT03084614
29 Microbiologic Findings of Acute Facial Palsy in Children Completed NCT01537952
30 Doxycycline in Therapy of Erythema Migrans Completed NCT01475708 Doxycycline
31 Study of Anti-HIV Therapy Intensification Completed NCT00034086 Lopinavir/Ritonavir;Lamivudine/Zidovudine;Tenofovir disoproxil fumarate;Lamivudine;Stavudine;Zidovudine;Didanosine
32 Duration of Antibiotic Treatment of Erythema Migrans Completed NCT00910715 doxycycline;doxycycline;placebo
33 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830
34 Evaluation, Treatment, and Follow-up of Patients With Lyme Disease Recruiting NCT00028080
35 Evaluation of Lyme Disease: Clinical, Microbiological and Immunological Characteristics Recruiting NCT00001539
36 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082
37 Lyme Test Indication Combinations (LyTIC) Study Recruiting NCT03201042
38 Analysis of Lyme Disease Lesions Recruiting NCT00132327
39 Lyme Borreliosis and Early Cutaneous Diagnostic Recruiting NCT02414789
40 Sofia 2 Lyme FIA Whole Blood Clinical Study Recruiting NCT03238274
41 Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health Recruiting NCT02669212
42 Screening for the Transthyretin-Related Familial Amyloidotic Small Fiber Polyneuropathy Recruiting NCT01705626
43 Tick-borne Encephalitis and Positive Borrelial Antibodies Recruiting NCT02463942 Doxycycline;Symptomatic therapy
44 Duration of Doxycycline Treatment in MEM Patients Recruiting NCT03337932 Doxycycline 100 milligram Oral Tablet bid, 7 days;Doxycycline 100 milligram Oral Tablet bid, 14 days;Controls without a history of lyme disease.
45 Duration of Doxycycline Treatment in EM Patients Recruiting NCT03153267 Doxycycline 100 MG Oral Tablet bid, 7 days;Doxycycline 100 MG Oral Tablet bid, 14 days;Controls without a history of lyme disease.
46 Laboratory Characteristics in Chronic Atrophic Acrodermatitis Recruiting NCT02147262 doxycycline orally, 100 mg, bid, 14 days;doxycycline orally, 100 mg, bid, 28 days
47 Central Nervous System Infections in Denmark Recruiting NCT03418441
48 Screening for Hereditary Transthyretin Related Amyloidosis-an Nationales, Multicentre, Epidemiological Protocol Recruiting NCT03237494
49 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
50 Cytokines and Chemokines in Erythema Migrans Recruiting NCT02147249 antibiotic treatment

Search NIH Clinical Center for Lyme Disease

Cochrane evidence based reviews: lyme disease

Genetic Tests for Lyme Disease

Anatomical Context for Lyme Disease

MalaCards organs/tissues related to Lyme Disease:

38
Heart, Skin, Testes, Eye, Brain, Whole Blood, Lung

Publications for Lyme Disease

Articles related to Lyme Disease:

(show top 50) (show all 831)
# Title Authors Year
1
Exploring an alternative approach to Lyme disease surveillance in Maryland. ( 29411541 )
2018
2
The Financial Implications of a Well-Hidden and Ignored Chronic Lyme Disease Pandemic. ( 29438352 )
2018
3
Development and Validation of a Serologic Test Panel for Detection of Powassan Virus Infection in U.S. Patients Residing in Regions Where Lyme Disease Is Endemic. ( 29359181 )
2018
4
An Unusual Cluster of Neuroinvasive Lyme Disease Cases Presenting With Bannwarth Syndrome in the Midwest United States. ( 29383323 )
2018
5
Obsessive-compulsive symptoms in adults with Lyme disease. ( 29408088 )
2018
6
Correction to: Development of a sensitive PCR-dot blot assay to supplement serological tests for diagnosing Lyme disease. ( 29404837 )
2018
7
Exacerbation of chronic pain after dental extractions in a patient with post-treatment Lyme disease syndrome. ( 29416466 )
2018
8
Lack of Evidence for Transovarial Transmission of the Lyme Disease Spirochete Borrelia mayonii by Infected Female Ixodes scapularis (Acari: Ixodidae) Ticks. ( 29365151 )
2018
9
Multiflora rose invasion amplifies prevalence of Lyme disease pathogen, but not necessarily Lyme disease risk. ( 29361971 )
2018
10
Relative Risk for Ehrlichiosis and Lyme Disease Where Vectors for Both Are Sympatric, Southeastern United States. ( 29350157 )
2018
11
Sleep Quality in Well-defined Lyme Disease: A Clinical Cohort Study in Maryland. ( 29452400 )
2018
12
Amblyomma americanum (Acari: Ixodidae) Ticks Are Not Vectors of the Lyme Disease Agent, Borrelia burgdorferi (Spirocheatales: Spirochaetaceae): A Review of the Evidence. ( 29394366 )
2018
13
Lyme Disease Testing in a High-Incidence State: Clinician Knowledge and Patterns. ( 29425271 )
2018
14
Lyme disease surveillance in the United States: Looking for ways to cut the Gordian knot. ( 29431297 )
2018
15
Tick borne illness-Lyme disease. ( 29402399 )
2018
16
Humanizing the digital revolution, the secret life of yeast and Lyme disease through a climate lens: Books in brief. ( 29446403 )
2018
17
Borrelia burgdorferi in small mammal reservoirs in Kentucky, a traditionally non-endemic state for Lyme disease. ( 29417273 )
2018
18
Ticks transmitting Lyme disease are found in a third of Britain, mainly the south. ( 29440061 )
2018
19
Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR. ( 29443061 )
2018
20
A Bayesian spatio-temporal model for forecasting the prevalence of antibodies to Borrelia burgdorferi, causative agent of Lyme disease, in domestic dogs within the contiguous United States. ( 28472096 )
2017
21
A critical appraisal of the mild axonal peripheral neuropathy of late neurologic Lyme disease. ( 27914746 )
2017
22
Practices of Lyme disease diagnosis and treatment by general practitioners in Quebec, 2008-2015. ( 28532428 )
2017
23
Environmental Factors Affecting Survival of Immature Ixodes scapularis and Implications for Geographical Distribution of Lyme Disease: The Climate/Behavior Hypothesis. ( 28076359 )
2017
24
Metabolic differentiation of early Lyme disease from southern tick-associated rash illness (STARI). ( 28814545 )
2017
25
Clinical association: Lyme disease and Guillain-Barre syndrome. ( 28711274 )
2017
26
Division of the genus Borrelia into two genera (corresponding to Lyme disease and relapsing fever groups) reflects their genetic and phenotypic distinctiveness and will lead to a better understanding of these two groups of microbes (Margos et al. (2016) There is inadequate evidence to support the division of the genus Borrelia. Int. J. Syst. Evol. Microbiol. doi: 10.1099/ijsem.0.001717). ( 28141502 )
2017
27
Effects of intravenous ketamine in a patient with post-treatment Lyme disease syndrome. ( 28860873 )
2017
28
A Case of Early Disseminated Neurological Lyme Disease Followed by Atypical Cutaneous Manifestations. ( 28512589 )
2017
29
Call for more Lyme disease research. ( 28947551 )
2017
30
Gene Sequencing and Cases of Chronic Lyme Disease-Reply. ( 28460104 )
2017
31
Celebrity over science? An analysis of Lyme disease video content on YouTube. ( 28898716 )
2017
32
Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control. ( 28438910 )
2017
33
A systematic review and meta-analysis for the adverse effects, immunogenicity and efficacy of Lyme disease vaccines: Guiding novel vaccine development. ( 28425901 )
2017
34
Lyme Disease and YouTubeTM: A Cross-Sectional Study of Video Contents. ( 28904853 )
2017
35
Identification of Tp0751 (Pallilysin) as a Treponema pallidum Vascular Adhesin by Heterologous Expression in the Lyme disease Spirochete. ( 28484210 )
2017
36
Lyme Disease: A Case Report with Typical and Atypical Lesions. ( 28405553 )
2017
37
Comparison of Vector Efficiency of Ixodes scapularis (Acari: Ixodidae) From the Northeast and Upper Midwest of the United States for the Lyme Disease Spirochete Borrelia mayonii. ( 28082653 )
2017
38
Concurrent babesiosis and serological evidence of Lyme disease in a young patient. ( 28634526 )
2017
39
Chronic Lyme Disease: An Unresolved Controversy. ( 28838739 )
2017
40
Succinyl-I^-cyclodextrin modified gold biochip improved seroimmunological detection sensitivity for Lyme disease. ( 28010742 )
2017
41
Suicidal and homicidal tendencies after Lyme disease: an ignored problem. ( 28814875 )
2017
42
Transmission of the Lyme Disease Spirochete Borrelia mayonii in Relation to Duration of Attachment by Nymphal Ixodes scapularis (Acari: Ixodidae). ( 28874016 )
2017
43
Brave New Worlds: The Expanding Universe of Lyme Disease. ( 28727515 )
2017
44
Relative Risk for Ehrlichiosis and Lyme Disease in an Area Where Vectors for Both Are Sympatric, New Jersey, USA. ( 28518034 )
2017
45
TH17 Cytokine Responses in Lyme Disease Correlate with Borreliaburgdorferi Antibodies During Early Infection in Patients with Erythema Migrans and with Autoantibodies Late in the Illness in Patients with Antibiotic-Refractory Lyme Arthritis. ( 28077518 )
2017
46
Application of Bayesian decision-making to laboratory testing for Lyme disease and comparison with testing for HIV. ( 28435311 )
2017
47
Neuroretinitis as presenting and the only presentation of Lyme disease: Diagnosis and management. ( 28440258 )
2017
48
Gene Sequencing and Cases of Chronic Lyme Disease. ( 28460095 )
2017
49
Treatment-Related Complications in Children Hospitalized With Disseminated Lyme Disease. ( 28903521 )
2017
50
Identification of a defined linear epitope in the OspA protein of the Lyme disease spirochetes that elicits bactericidal antibody responses: Implications for vaccine development. ( 28479174 )
2017

Variations for Lyme Disease

Expression for Lyme Disease

Search GEO for disease gene expression data for Lyme Disease.

Pathways for Lyme Disease

Pathways related to Lyme Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 C3 CD40LG CFH CRP IL17A IL1B
2
Show member pathways
13.38 CD40LG IL17A IL1B IL6 TLR1 TLR2
3
Show member pathways
12.97 IL1B IL6 TLR1 TLR2 TLR6 TNF
4
Show member pathways
12.79 C3 IL1B IL6 TLR2 TNF
5
Show member pathways
12.79 C3 CD40LG HSPD1 IL17A IL1B IL6
6
Show member pathways
12.64 CD40LG IL1B IL6 TLR1 TLR2 TLR6
7
Show member pathways
12.61 CD40LG IL1B TLR1 TLR2 TLR6 TNF
8
Show member pathways
12.6 IL17A IL1B IL6 TLR2 TNF
9
Show member pathways
12.55 IL17A IL1B IL6 TNF
10
Show member pathways
12.54 C3 IL6 TLR2 TNF
11 12.49 CD40LG IL17A IL1B TLR1 TLR2 TLR6
12
Show member pathways
12.43 CD40LG IL17A IL1B IL6 TNF
13
Show member pathways
12.4 C3 IL1B IL6 TLR1 TLR2 TLR6
14
Show member pathways
12.33 CRP IL1B IL6 TNF
15
Show member pathways
12.32 IL17A IL1B IL6 TLR2 TNF
16
Show member pathways
12.25 IL6 TLR1 TLR2 TLR6 TNF
17
Show member pathways
12.24 C3 CD40LG IL1B TLR2 TNF
18 12.19 HSPD1 IL1B IL6 TNF
19
Show member pathways
12.17 IL17A IL1B IL6 TNF
20 12.14 IL6 TLR1 TLR2 TLR6 TNF
21
Show member pathways
12.1 IL1B IL6 TLR1 TLR2 TLR6 TNF
22
Show member pathways
12.04 IL1B TLR1 TLR2 TLR6
23 12 IL17A IL1B IL6 TNF
24 11.98 IL1B IL6 TNF
25 11.92 IL1B IL6 TNF
26 11.9 IL1B IL6 TLR2 TNF
27 11.88 IL1B IL6 TNF
28 11.87 IL1B IL6 TNF
29 11.86 CD40LG IL1B TNF
30 11.84 C3 TLR1 TLR2 TLR6
31 11.81 IL17A IL1B IL6 TLR2 TNF
32 11.78 IL17A IL1B TNF
33 11.77 C3 IL1B IL6 TNF
34 11.74 IL1B IL6 TNF
35
Show member pathways
11.69 IL17A IL1B IL6 TLR1 TLR2 TLR6
36 11.67 IL1B IL6 TNF
37 11.67 CD40LG IL6 TLR2 TNF
38
Show member pathways
11.64 CD40LG IL1B IL6 TNF
40 11.55 IL1B IL6 TNF
41 11.54 IL1B TLR2 TNF
42
Show member pathways
11.52 IL17A IL1B IL6 TLR1 TLR2 TLR6
43 11.51 IL1B IL6 TNF
44 11.48 C3 HSPD1 IL1B IL6 TLR1 TLR2
45 11.41 CD40LG IL1B IL6 TLR2 TNF
46 11.38 IL1B IL6 TNF
47 11.38 IL1B IL6 TNF
48 11.37 C3 HSPD1 IL1B IL6 TLR2 TNF
49 11.32 IL1B IL6 TNF
50 11.3 IL1B IL6 TNF

GO Terms for Lyme Disease

Cellular components related to Lyme Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 C3 CD40LG CFH CFHR1 CRP IL17A
2 membrane raft GO:0045121 9.56 TLR1 TLR2 TLR6 TNF
3 phagocytic vesicle membrane GO:0030670 9.5 TLR1 TLR2 TLR6
4 extracellular space GO:0005615 9.32 C3 CD40LG CFH CFHR1 CRP HSPD1
5 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.96 TLR1 TLR2

Biological processes related to Lyme Disease according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 CRP IL1B IL6 TLR2 TLR6 TNF
2 regulation of complement activation GO:0030449 9.87 C3 CFH CFHR1
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.87 IL1B IL6 TNF
4 complement activation GO:0006956 9.86 C3 CFH CFHR1
5 positive regulation of T cell proliferation GO:0042102 9.84 CD40LG IL1B IL6
6 toll-like receptor signaling pathway GO:0002224 9.81 TLR1 TLR2 TLR6
7 positive regulation of interferon-gamma production GO:0032729 9.81 HSPD1 IL1B TNF
8 defense response to Gram-positive bacterium GO:0050830 9.81 CRP IL6 TLR2 TNF
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 IL1B TLR6 TNF
10 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 IL1B TLR2 TNF
11 positive regulation of phagocytosis GO:0050766 9.77 C3 IL1B TNF
12 positive regulation of interleukin-8 production GO:0032757 9.73 IL1B TLR2 TNF
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 CD40LG IL1B IL6 TLR2 TLR6 TNF
14 positive regulation of interleukin-12 production GO:0032735 9.72 CD40LG HSPD1 TLR2
15 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
17 positive regulation of interleukin-10 production GO:0032733 9.71 CD40LG HSPD1 TLR2
18 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.7 IL17A TLR6
19 positive regulation of macrophage activation GO:0043032 9.7 HSPD1 TLR6
20 positive regulation of NF-kappaB import into nucleus GO:0042346 9.7 IL1B TLR2 TNF
21 microglial cell activation GO:0001774 9.69 TLR2 TLR6
22 positive regulation of interleukin-8 secretion GO:2000484 9.69 TLR1 TLR2
23 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.69 IL1B TNF
24 complement activation, alternative pathway GO:0006957 9.68 C3 CFH
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL1B TNF
26 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B TNF
27 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
28 positive regulation of chemokine production GO:0032722 9.67 IL6 TLR2 TNF
29 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
30 regulation of immunoglobulin secretion GO:0051023 9.65 CD40LG TNF
31 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
32 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.65 TLR2 TLR6
33 cell activation GO:0001775 9.65 TLR1 TLR2 TLR6
34 cellular response to diacyl bacterial lipopeptide GO:0071726 9.64 TLR2 TLR6
35 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IL1B TNF
36 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.62 TLR1 TLR2
37 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.62 HSPD1 TLR1 TLR2 TLR6
38 cellular response to triacyl bacterial lipopeptide GO:0071727 9.61 TLR1 TLR2
39 nitric oxide metabolic process GO:0046209 9.61 TLR2 TLR6
40 regulation of cytokine secretion GO:0050707 9.61 TLR1 TLR2 TLR6
41 immune response GO:0006955 9.61 C3 CD40LG IL17A IL1B IL6 TLR1
42 detection of triacyl bacterial lipopeptide GO:0042495 9.58 TLR1 TLR2
43 detection of diacyl bacterial lipopeptide GO:0042496 9.58 TLR2 TLR6
44 negative regulation of lipid storage GO:0010888 9.58 CRP IL6 TNF
45 response to bacterial lipoprotein GO:0032493 9.57 TLR2 TLR6
46 positive regulation of interleukin-6 production GO:0032755 9.55 HSPD1 IL1B IL6 TLR2 TNF
47 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.54 IL1B TLR1 TLR6
48 inflammatory response GO:0006954 9.32 C3 CD40LG CRP IL17A IL1B IL6
49 innate immune response GO:0045087 10.07 C3 CFH TLR1 TLR2 TLR6
50 regulation of receptor activity GO:0010469 10.06 CD40LG IL17A IL1B IL6 TNF

Molecular functions related to Lyme Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 CD40LG IL17A IL1B IL6 TNF
2 Toll-like receptor 2 binding GO:0035663 9.26 TLR1 TLR6
3 lipopeptide binding GO:0071723 8.8 TLR1 TLR2 TLR6
4 protein binding GO:0005515 10.03 C3 CD40LG CFH CFHR1 CLDN11 CRP

Sources for Lyme Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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