MCID: LYM017
MIFTS: 63

Lyme Disease malady

Categories: Rare diseases, Infectious diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Lyme Disease

Aliases & Descriptions for Lyme Disease:

Name: Lyme Disease 12 50 56 52 41 3 42 14 69
Lyme Neuroborreliosis 12 52 42 69
Lyme Borreliosis 12 50 56 14
Neuroborreliosis 12 69
Borreliosis 50 52
Neurological Lyme Disease 12
Bannworth's Syndrome 12
Borrelia Infections 69
Bannwarth Syndrome 12

Characteristics:

Orphanet epidemiological data:

56
lyme disease
Inheritance: Not applicable; Prevalence: >1/1000 (Europe),1-5/10000 (France); Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:11729
ICD10 33 A69.2 A69.20
ICD9CM 35 088.81
NCIt 47 C45161
Orphanet 56 ORPHA91546
MESH via Orphanet 43 D008193
UMLS via Orphanet 70 C0024198
ICD10 via Orphanet 34 A69.2

Summaries for Lyme Disease

MedlinePlus : 41 lyme disease is a bacterial infection you get from the bite of an infected tick. the first symptom is usually a red rash, which may look like a bull's eye. but not all people with lyme disease have a rash. as the infection spreads to other parts of the body, you may have a fever a headache body aches a stiff neck fatigue lyme disease can be hard to diagnose because many of its symptoms are like those of the flu and other diseases. and you may not have noticed a tick bite. your health care provider will look at your symptoms and medical history to figure out whether you have lyme disease. lab tests may not always give a clear answer until you have been infected for at least a few weeks. antibiotics can cure most cases of lyme disease. the sooner treatment begins, the quicker and more complete the recovery. after treatment, some patients may still have muscle or joint aches and nervous system symptoms. this is called post-treatment lyme disease syndrome (ptlds). long-term antibiotics have not been shown to help with ptlds. however, there are ways to help with the symptoms of ptlds, and most patients do get better with time. nih: national institute of allergy and infectious diseases

MalaCards based summary : Lyme Disease, also known as lyme neuroborreliosis, is related to spotted fever and neuropathy, and has symptoms including fever, headache and fatigue. An important gene associated with Lyme Disease is YBX3 (Y-Box Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ceftriaxone and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and skin, and related phenotypes are hematopoietic system and immune system

NIH Rare Diseases : 50 lyme disease is the most common tickborne infectious disease in the united states. early signs and symptoms of the condition include fever, chills, muscle pain, headache, and joint pain. as the condition progresses, affected people may experience heart problems, bell's palsy, arthritis, abnormal muscle movement, speech problems and cognitive (thinking) abnormalities. please visit the center for disease control and prevention's web site for a more comprehensive list of symptoms. lyme disease is caused by the bacterium borrelia burgdorferi, which is transmitted to humans through the bite of infected blacklegged ticks. certain features of the condition, including whether or not an affected person will develop medication-resistant chronic arthritis, is thought to be influenced by genetic factors (certain human leukocyte antigen genes). treatment generally includes antibiotics to address the bacterial infection and other medications (i.e. pain medications) to relieve symptoms. last updated: 10/6/2015

CDC : 3 Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected blacklegged ticks. Typical symptoms include fever, headache, fatigue, and a characteristic skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. Lyme disease is diagnosed based on symptoms, physical findings (e.g., rash), and the possibility of exposure to infected ticks.  Laboratory testing is helpful if used correctly and performed with validated methods. Most cases of Lyme disease can be treated successfully with a few weeks of antibiotics. Steps to prevent Lyme disease include using insect repellent, removing ticks promptly, applying pesticides, and reducing tick habitat. The ticks that transmit Lyme disease can occasionally transmit other tickborne diseases as well.

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection, has material basis in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has symptom fever, has symptom headache, has symptom fatigue, and has symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.

Wikipedia : 71 Lyme disease, also known as Lyme borreliosis, is an infectious disease caused by bacteria of the... more...

Related Diseases for Lyme Disease

Diseases related to Lyme Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 313)
id Related Disease Score Top Affiliating Genes
1 spotted fever 30.1 CD40LG TLR2 TNF
2 neuropathy 29.9 IL1B IL6 TNF
3 choroiditis 29.6 IL1B IL6 TNF
4 oculomotor nerve paralysis 29.5 IL1B IL6
5 central nervous system lymphoma 29.3 IL1B IL6 TNF
6 tuberculosis 28.9 CD40LG IL17A IL1B IL6 TNF
7 rheumatoid arthritis 28.3 CD40LG HSPD1 IL17A IL1B IL6 TLR2
8 lyme disease - neurological complications 12.2
9 babesiosis 11.1
10 human granulocytic anaplasmosis 11.1
11 tick infestation 11.1
12 powassan encephalitis 11.1
13 intermediate uveitis 10.7
14 atrophoderma of pierini and pasini 10.7
15 autoimmune inner ear disease 10.7
16 idiopathic hypertrophic pachymeningitis 10.7
17 lymphocytic infiltrate of jessner 10.7
18 pseudopelade of brocq 10.7
19 pars planitis 10.7
20 monosomy 9q22.3 10.2 C3 MMP9
21 macular degeneration, age-related, 4 10.2 CFH CFHR1
22 premature menopause 10.2 HSPD1 IL6 TLR2
23 lateral cystocele 10.2 CD40LG IL6 TLR1
24 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
25 usher syndrome, type 2a 10.2 IL6 TLR1 TLR2
26 intussusception 10.2 IL1B TNF
27 immune-complex glomerulonephritis 10.2 C3 CFH IL6
28 relapsing fever 10.2
29 ehrlichiosis 10.2
30 common peroneal nerve lesion 10.1 IL1B IL6
31 mycoplasmal pneumonia 10.1 TLR1 TLR2 TNF
32 congenital hypothyroidism 10.1 CD40LG TLR2 TNF
33 gastric leiomyoma 10.1 CD40LG IL1B IL6
34 toxic optic neuropathy 10.1 IL1B MMP9
35 endogenous depression 10.1 CD40LG TLR2 TNF
36 basilar artery occlusion 10.1 CD40LG HSPD1 TLR6
37 dyslexia 5 10.1 IL6 TNF
38 dentin caries 10.1 CD40LG TLR2 TNF
39 tau syndrome 10.1 IL1B TNF
40 early yaws 10.1 CD40LG IL1B IL6
41 cardioskeletal syndrome, kuwaiti type 10.1 TLR1 TLR2 TLR6
42 conduct disorder 10.1 CD40LG IL6 TNF
43 childhood pleomorphic rhabdomyosarcoma 10.1 CD40LG IL6 TNF
44 fibrosis of extraocular muscles, congenital, 1 10.1 TLR1 TLR2 TLR6
45 hereditary alpha tryptasemia syndrome 10.1 CD40LG IL6 TNF
46 cicatricial lagophthalmos 10.1 CFHR1 IL6 TNF
47 ectothrix infectious disease 10.1 TLR1 TLR2 TLR6
48 dermatomycosis 10.1 C3 CD40LG TNF
49 plummer's disease 10.1 CD40LG IL6 TNF
50 multiple vertebral anomalies unusual facies 10.1 CFH TNF

Graphical network of the top 20 diseases related to Lyme Disease:



Diseases related to Lyme Disease

Symptoms & Phenotypes for Lyme Disease

Symptoms:

12
  • fever
  • headache
  • fatigue
  • skin rash called erythema migrans

Human phenotypes related to Lyme Disease:

56 32 (show all 24)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 56 32 Occasional (29-5%) HP:0002829
2 fatigue 56 32 Occasional (29-5%) HP:0012378
3 myalgia 56 32 Occasional (29-5%) HP:0003326
4 fever 56 32 Occasional (29-5%) HP:0001945
5 headache 56 32 Occasional (29-5%) HP:0002315
6 photophobia 56 32 Occasional (29-5%) HP:0000613
7 joint swelling 56 32 Frequent (79-30%) HP:0001386
8 nausea and vomiting 56 32 Occasional (29-5%) HP:0002017
9 muscle weakness 56 32 Occasional (29-5%) HP:0001324
10 amaurosis fugax 56 32 Occasional (29-5%) HP:0100576
11 encephalitis 56 32 Occasional (29-5%) HP:0002383
12 arthritis 56 32 Frequent (79-30%) HP:0001369
13 cranial nerve paralysis 56 32 Frequent (79-30%) HP:0006824
14 atrioventricular block 56 32 Occasional (29-5%) HP:0001678
15 memory impairment 56 32 Occasional (29-5%) HP:0002354
16 paresthesia 56 32 Occasional (29-5%) HP:0003401
17 meningitis 56 32 Frequent (79-30%) HP:0001287
18 insomnia 56 32 Occasional (29-5%) HP:0100785
19 uveitis 56 32 Occasional (29-5%) HP:0000554
20 skin nodule 56 32 Occasional (29-5%) HP:0200036
21 dermal atrophy 56 32 Occasional (29-5%) HP:0004334
22 behavioral abnormality 56 Occasional (29-5%)
23 arrhythmia 56 Occasional (29-5%)
24 peripheral neuropathy 56 Occasional (29-5%)

UMLS symptoms related to Lyme Disease:


fever, pruritus

MGI Mouse Phenotypes related to Lyme Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.14 TLR2 TLR6 TNF C3 CD40LG CFH
2 immune system MP:0005387 10.11 C3 CD40LG CFH IL17A IL1B IL6
3 cardiovascular system MP:0005385 10.06 C3 CD40LG CFH IL1B IL6 MMP9
4 mortality/aging MP:0010768 10.06 C3 CD40LG CFH HSPD1 IL17A IL1B
5 endocrine/exocrine gland MP:0005379 10.03 C3 CD40LG CLDN11 IL17A IL6 TLR2
6 nervous system MP:0003631 10 C3 CD40LG CFH CLDN11 HSPD1 IL1B
7 renal/urinary system MP:0005367 9.7 C3 CD40LG CFH IL17A IL6 MMP9
8 reproductive system MP:0005389 9.61 IL6 MMP9 TLR6 TNF YBX3 C3
9 skeleton MP:0005390 9.23 C3 CD40LG IL17A IL1B IL6 MMP9

Drugs & Therapeutics for Lyme Disease

Drugs for Lyme Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftriaxone Approved Phase 4,Phase 3,Phase 1,Phase 2 73384-59-5 5479530 5361919
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
3
Clarithromycin Approved Phase 4 81103-11-9 84029
4
Hydroxychloroquine Approved Phase 4 118-42-3 3652
5
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
6
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
7
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
8
Azithromycin Approved Phase 4,Phase 1,Phase 2 83905-01-5 55185 53477736 447043
9
Erythromycin Approved, Vet_approved Phase 4 114-07-8 12560
10
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
12 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Antimalarials Phase 4,Phase 3,Phase 2
15 Antiparasitic Agents Phase 4,Phase 3,Phase 2
16 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
17 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
18 Antirheumatic Agents Phase 4
19 Antitubercular Agents Phase 4,Phase 2
20 Cytochrome P-450 CYP3A Inhibitors Phase 4
21 Cytochrome P-450 Enzyme Inhibitors Phase 4
22 penicillins Phase 4
23 cefuroxime axetil Phase 4
24 Erythromycin Estolate Phase 4
25 Erythromycin Ethylsuccinate Phase 4
26 Erythromycin stearate Phase 4
27 Antiemetics Phase 4
28 Autonomic Agents Phase 4
29 Gastrointestinal Agents Phase 4,Phase 1
30 Peripheral Nervous System Agents Phase 4
31 Anti-Inflammatory Agents Phase 4
32 Antineoplastic Agents, Hormonal Phase 4
33 glucocorticoids Phase 4
34 Hormone Antagonists Phase 4
35 Hormones Phase 4
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
37 Methylprednisolone acetate Phase 4
38 Methylprednisolone Hemisuccinate Phase 4
39 Neuroprotective Agents Phase 4
40 Prednisolone acetate Phase 4
41 Prednisolone hemisuccinate Phase 4
42 Prednisolone phosphate Phase 4
43 Protective Agents Phase 4
44
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
45
Osimertinib Approved Phase 3 1421373-65-0 71496458
46
Permethrin Approved, Investigational Phase 3 52645-53-1 40326
47 Vaccines Phase 3,Phase 1,Phase 2
48 Mitogens Phase 3
49 Protein Kinase Inhibitors Phase 3
50 PENTA Phase 3

Interventional clinical trials:

(show top 50) (show all 62)
id Name Status NCT ID Phase
1 Study of Lyme Neuroborreliosis Unknown status NCT01635530 Phase 4
2 Persistent Lyme Empiric Antibiotic Study Europe Completed NCT01207739 Phase 4
3 Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice Completed NCT01368341 Phase 4
4 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed NCT01518192 Phase 4
5 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4
6 The Study to Treat Superficial Femoral Artery Occlusions. Completed NCT00232843 Phase 4
7 Injection Versus Splinting in Carpal Tunnel Syndrome Active, not recruiting NCT02038452 Phase 4
8 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3
9 A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seropositive Chronic Lyme Disease Completed NCT00001101 Phase 3
10 A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seronegative Chronic Lyme Disease Completed NCT00000938 Phase 3
11 Study and Treatment of Post Lyme Disease (STOP-LD) Completed NCT00000937 Phase 3
12 Lyme Disease Prevention Program Completed NCT00000432 Phase 3
13 Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever Completed NCT00237016 Phase 2, Phase 3
14 Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis Completed NCT00138801 Phase 3
15 Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects Completed NCT00698568 Phase 3
16 Real World Treatment Study of AZD9291 for Advanced/Metastatic EGFR T790M Mutation NSCLC Recruiting NCT02474355 Phase 3
17 Benralizumab Efficacy in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With Exacerbation History Active, not recruiting NCT02138916 Phase 3
18 Six Versus Two Weeks Treatment With Doxycycline in Lyme Neuroborreliosis Enrolling by invitation NCT02553473 Phase 3
19 Passive Prophylaxis of Lyme Disease Using Permethrin Treated Clothes Terminated NCT00958139 Phase 3
20 A Placebo-controlled Efficacy Study of IV Ceftriaxone for Refractory Psychosis Unknown status NCT00591318 Phase 1, Phase 2
21 Phase 1/2 Lyme Vaccine Study Completed NCT01504347 Phase 1, Phase 2
22 Safety, Skin and Plasma Concentration of Azithromycin Dermal Formulation Completed NCT01243008 Phase 1, Phase 2
23 Brain Imaging and Retreatment Study of Persistent Lyme Disease Completed NCT00037479 Phase 2
24 Antibiotic Treatment Trial for the PANDAS/PANS Phenotype Completed NCT01617083 Phase 2
25 Efficacy of 1072nm Infrared Stimulation on Executive Functioning in Dementia Completed NCT01059877 Phase 1, Phase 2
26 Xenodiagnosis After Antibiotic Treatment for Lyme Disease Recruiting NCT02446626 Phase 1, Phase 2
27 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
28 Study Assessing the Safety, Immunogenicity and Dose Response of VLA15, A New Vaccine Candidate Against Lyme Borreliosis Recruiting NCT03010228 Phase 1
29 Lyme Borreliosis and Early Cutaneous Diagnostic Unknown status NCT02414789
30 Human Anaplasmosis in Eastern France Unknown status NCT01013636
31 Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis Unknown status NCT00942006
32 Meditation and Stretching for Post Treatment Lyme Disease Syndrome Unknown status NCT02344537
33 300 Antibody Diagnostic Test Kit Unknown status NCT01646411
34 Doxycycline in Therapy of Erythema Migrans Completed NCT01475708
35 Duration of Antibiotic Treatment of Erythema Migrans Completed NCT00910715
36 The Phenomenon of "Chronic Lyme"; an Observational Study Completed NCT01151150
37 Microbiologic Findings of Acute Facial Palsy in Children Completed NCT01537952
38 Culture Media for Borrelia Burgdorferi Sensu Lato Completed NCT02145754
39 Searching for Persistence of Infection in Lyme Disease Completed NCT01143558 Early Phase 1
40 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830
41 Study of Anti-HIV Therapy Intensification Completed NCT00034086
42 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082
43 Study on Early Lyme Neuroborreliosis Recruiting NCT00910533
44 Tick-borne Encephalitis and Positive Borrelial Antibodies Recruiting NCT02463942
45 Cytokines and Chemokines in Erythema Migrans Recruiting NCT02147249
46 Antibiotic Treatment of Multiple Erythema Migrans Recruiting NCT01163994
47 Laboratory Characteristics in Chronic Atrophic Acrodermatitis Recruiting NCT02147262
48 Evaluation of Lyme Disease: Clinical, Microbiological and Immunological Characteristics Recruiting NCT00001539
49 Evaluation, Treatment, and Follow-up of Patients With Lyme Disease Recruiting NCT00028080
50 A Multicenter Study to Evaluate a Borrelia Diagnostic Test in Subjects With Early Stage or Late Stage Lyme Disease Recruiting NCT02741609

Search NIH Clinical Center for Lyme Disease

Cochrane evidence based reviews: lyme disease

Genetic Tests for Lyme Disease

Anatomical Context for Lyme Disease

MalaCards organs/tissues related to Lyme Disease:

39
Heart, Testes, Skin, Eye, Brain, T Cells, Endothelial

Publications for Lyme Disease

Articles related to Lyme Disease:

(show top 50) (show all 785)
id Title Authors Year
1
A critical appraisal of the mild axonal peripheral neuropathy of late neurologic Lyme disease. ( 27914746 )
2017
2
Tick bite and Lyme disease-related emergency department encounters in New Hampshire, 2010-2014. ( 28432738 )
2017
3
Relative Risk for Ehrlichiosis and Lyme Disease in an Area Where Vectors for Both Are Sympatric, New Jersey, USA. ( 28518034 )
2017
4
Lyme Disease: A Case Report with Typical and Atypical Lesions. ( 28405553 )
2017
5
Isolation of the Lyme Disease Spirochete Borrelia mayonii From Naturally Infected Rodents in Minnesota. ( 28444198 )
2017
6
Use of a tick-borne disease manual increases accuracy of tick identification among primary care providers in Lyme disease endemic areas. ( 27916581 )
2017
7
A Bayesian spatio-temporal model for forecasting the prevalence of antibodies to Borrelia burgdorferi, causative agent of Lyme disease, in domestic dogs within the contiguous United States. ( 28472096 )
2017
8
Temperature-dependent sRNA transcriptome of the Lyme disease spirochete. ( 28056764 )
2017
9
Identification of Tp0751 (Pallilysin) as a Treponema pallidum Vascular Adhesin by Heterologous Expression in the Lyme disease Spirochete. ( 28484210 )
2017
10
Dealing with Lyme Disease Treatment. ( 28431674 )
2017
11
Comparison of Vector Efficiency of Ixodes scapularis (Acari: Ixodidae) From the Northeast and Upper Midwest of the United States for the Lyme Disease Spirochete Borrelia mayonii. ( 28082653 )
2017
12
Lyme disease risk in southern California: abiotic and environmental drivers of Ixodes pacificus (Acari: Ixodidae) density and infection prevalence with Borrelia burgdorferi. ( 28057067 )
2017
13
Gene Sequencing and Cases of Chronic Lyme Disease-Reply. ( 28460104 )
2017
14
Environmental Factors Affecting Survival of Immature Ixodes scapularis and Implications for Geographical Distribution of Lyme Disease: The Climate/Behavior Hypothesis. ( 28076359 )
2017
15
Gene Sequencing and Cases of Chronic Lyme Disease. ( 28460095 )
2017
16
A Case of Early Disseminated Neurological Lyme Disease Followed by Atypical Cutaneous Manifestations. ( 28512589 )
2017
17
Geographic Expansion of Lyme Disease in Michigan, 2000-2014. ( 28480261 )
2017
18
Application of Bayesian decision-making to laboratory testing for Lyme disease and comparison with testing for HIV. ( 28435311 )
2017
19
A systematic review and meta-analysis for the adverse effects, immunogenicity and efficacy of Lyme disease vaccines: Guiding novel vaccine development. ( 28425901 )
2017
20
Neuroretinitis as presenting and the only presentation of Lyme disease: Diagnosis and management. ( 28440258 )
2017
21
TH17 Cytokine Responses in Lyme Disease Correlate with Borreliaburgdorferi Antibodies During Early Infection in Patients with Erythema Migrans and with Autoantibodies Late in the Illness in Patients with Antibiotic-Refractory Lyme Arthritis. ( 28077518 )
2017
22
Identification of a defined linear epitope in the OspA protein of the Lyme disease spirochetes that elicits bactericidal antibody responses: Implications for vaccine development. ( 28479174 )
2017
23
Borrelia burgdorferi-specific IgA in Lyme Disease. ( 28457619 )
2017
24
Evaluation of the SELECT Tick Control System (TCS), a Host-Targeted Bait Box, to Reduce Exposure to Ixodes scapularis (Acari: Ixodidae) in a Lyme Disease Endemic Area of New Jersey. ( 28399280 )
2017
25
Practices of Lyme disease diagnosis and treatment by general practitioners in Quebec, 2008-2015. ( 28532428 )
2017
26
Succinyl-I^-cyclodextrin modified gold biochip improved seroimmunological detection sensitivity for Lyme disease. ( 28010742 )
2017
27
Pleomorphism and Viability of the Lyme Disease Pathogen Borrelia burgdorferi Exposed to Physiological Stress Conditions: A Correlative Cryo-Fluorescence and Cryo-Scanning Electron Microscopy Study. ( 28443079 )
2017
28
Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control. ( 28438910 )
2017
29
Lyme Disease Serology. ( 27115380 )
2016
30
Lyme Disease. ( 27136224 )
2016
31
The latest evidence on Lyme disease. ( 27498520 )
2016
32
Not All Erythema Migrans Lesions are Lyme Disease. ( 27612442 )
2016
33
Longer-Term Therapy for Symptoms Attributed to Lyme Disease. ( 27602675 )
2016
34
Lyme disease. ( 27650153 )
2016
35
Yamamoto New Scalp Acupuncture, Applied Kinesiology, and Breathing Exercises for Facial Paralysis in a Young Boy Caused by Lyme Disease-A Case Report. ( 27102135 )
2016
36
False Positive Lyme Disease IgM Immunoblots in Children. ( 27157898 )
2016
37
Long-term Follow-up of Patients With Lyme Disease: Longitudinal Analysis of Clinical and Quality-of-life Measures. ( 27025825 )
2016
38
Palisaded neutrophilic and granulomatous dermatitis - cutaneous manifestation of Lyme disease or connected with CTD? Case report. ( 27294654 )
2016
39
A Case of Lyme Disease Accompanied by Uveitis and White Dot Syndrome. ( 28058168 )
2016
40
Time for a Different Approach to Lyme Disease and Long-Term Symptoms. ( 27028918 )
2016
41
Expression of C-Reactive Protein and Serum Amyloid A in Early to Late Manifestations of Lyme Disease. ( 27585799 )
2016
42
Longer-Term Therapy for Symptoms Attributed to Lyme Disease. ( 27602673 )
2016
43
Lyme Disease in West Virginia: An Assessment of Distribution and Clinicians' Knowledge of Disease and Surveillance. ( 27491103 )
2016
44
Steroid use in Lyme disease-associated facial palsy is associated with worse long-term outcomes. ( 27598389 )
2016
45
Susceptibility, likelihood to be diagnosed, worry and fear for contracting Lyme disease. ( 27026135 )
2016
46
Lyme disease caused by Borrelia burgdorferi with two homeologous 16S rRNA genes: a case report. ( 27186082 )
2016
47
When in Doubt, Examine the Patient: Commentary on an article by Keith D. Baldwin, MD, MSPT, MPH, et al.: "Predictive Factors for Differentiating Between Septic Arthritis and Lyme Disease of the Knee in Children". ( 27147695 )
2016
48
Evidence of rapid changes in Lyme disease awareness in Canada. ( 27665265 )
2016
49
Human Granulocytic Anaplasmosis and Lyme Disease. ( 27380349 )
2016
50
The Lyme disease pathogen Borrelia burgdorferi infects murine bone and induces trabecular bone loss. ( 27956598 )
2016

Variations for Lyme Disease

Expression for Lyme Disease

Search GEO for disease gene expression data for Lyme Disease.

Pathways for Lyme Disease

Pathways related to Lyme Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 C3 CD40LG CFH IL17A IL1B IL6
2
Show member pathways
13.39 CD40LG IL17A IL1B IL6 TLR1 TLR2
3
Show member pathways
12.99 IL1B IL6 TLR1 TLR2 TLR6 TNF
4
Show member pathways
12.86 C3 IL1B IL6 MMP9 TLR1 TLR2
5
Show member pathways
12.85 C3 CD40LG HSPD1 IL17A IL1B IL6
6
Show member pathways
12.79 C3 IL1B IL6 TLR2 TNF
7
Show member pathways
12.7 CD40LG IL1B IL6 TLR1 TLR2 TLR6
8
Show member pathways
12.62 CD40LG IL1B TLR1 TLR2 TLR6 TNF
9
Show member pathways
12.61 IL17A IL1B IL6 TLR2 TNF
10
Show member pathways
12.55 IL17A IL1B IL6 TNF
11
Show member pathways
12.44 CD40LG IL17A IL1B IL6 TNF
12 12.44 CD40LG IL17A IL1B TLR1 TLR2 TLR6
13
Show member pathways
12.33 IL17A IL1B IL6 MMP9 TLR2 TNF
14
Show member pathways
12.28 IL6 TLR1 TLR2 TLR6 TNF
15
Show member pathways
12.26 C3 CD40LG IL1B TLR2 TNF
16 12.2 HSPD1 IL1B IL6 TNF
17
Show member pathways
12.17 IL17A IL1B IL6 TNF
18
Show member pathways
12.15 IL1B IL6 TLR1 TLR2 TLR6 TNF
19 12.13 IL6 MMP9 TLR1 TLR2 TLR6 TNF
20
Show member pathways
12.05 IL1B TLR1 TLR2 TLR6
21 12.03 IL1B IL6 MMP9 TNF
22 12.01 IL17A IL1B IL6 MMP9 TNF
23 11.97 IL1B IL6 MMP9 TNF
24 11.91 IL1B IL6 TLR2 TNF
25 11.88 IL1B IL6 TNF
26 11.87 IL1B IL6 TNF
27 11.86 CD40LG IL1B TNF
28 11.86 IL17A IL1B IL6 TLR2 TNF
29 11.85 C3 TLR1 TLR2 TLR6
30 11.79 C3 IL1B IL6 TNF
31 11.78 IL17A IL1B TNF
32 11.76 IL1B IL6 TNF
33 11.75 CD40LG IL6 TLR2 TNF
34
Show member pathways
11.74 IL17A IL1B IL6 TLR1 TLR2 TLR6
35 11.68 IL1B IL6 MMP9 TNF
37
Show member pathways
11.57 CD40LG IL1B IL6 MMP9 TNF
38 11.56 IL1B IL6 TNF
39 11.55 IL6 MMP9 TNF
40 11.54 IL1B TLR2 TNF
41
Show member pathways
11.53 IL17A IL1B IL6 TLR1 TLR2 TLR6
42 11.51 IL1B IL6 TNF
43 11.48 C3 HSPD1 IL1B IL6 TLR1 TLR2
44 11.41 CD40LG IL1B IL6 TLR2 TNF
45 11.39 IL1B IL6 TNF
46 11.39 IL1B IL6 TNF
47 11.37 C3 HSPD1 IL1B IL6 TLR2 TNF
48 11.35 IL17A IL1B IL6 TNF
49 11.33 IL1B IL6 TNF
50 11.3 IL1B IL6 TNF

GO Terms for Lyme Disease

Cellular components related to Lyme Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 C3 CD40LG CFH CFHR1 IL17A IL1B
2 external side of plasma membrane GO:0009897 9.67 CD40LG IL17A IL6 TNF
3 phagocytic vesicle membrane GO:0030670 9.5 TLR1 TLR2 TLR6
4 membrane raft GO:0045121 9.35 HSPD1 TLR1 TLR2 TLR6 TNF
5 extracellular space GO:0005615 9.32 C3 CD40LG CFH CFHR1 HSPD1 IL17A
6 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.16 TLR1 TLR2

Biological processes related to Lyme Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.96 HSPD1 IL1B IL6 TLR2
2 positive regulation of protein phosphorylation GO:0001934 9.92 C3 IL1B MMP9 TNF
3 regulation of complement activation GO:0030449 9.88 C3 CFH CFHR1
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.88 IL1B IL6 TNF
5 complement activation GO:0006956 9.87 C3 CFH CFHR1
6 response to glucocorticoid GO:0051384 9.86 HSPD1 IL6 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.86 IL6 TLR2 TNF
8 positive regulation of T cell proliferation GO:0042102 9.85 CD40LG IL1B IL6
9 toll-like receptor signaling pathway GO:0002224 9.83 TLR1 TLR2 TLR6
10 positive regulation of interferon-gamma production GO:0032729 9.82 HSPD1 IL1B TNF
11 response to cold GO:0009409 9.8 HSPD1 IL6 YBX3
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 IL1B IL6 TNF
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 CD40LG IL1B IL6 TLR2 TNF
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 IL1B TLR2 TNF
15 positive regulation of phagocytosis GO:0050766 9.75 C3 IL1B TNF
16 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
17 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.71 MMP9 TNF
18 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
19 positive regulation of interleukin-8 production GO:0032757 9.71 IL1B TLR2 TNF
20 microglial cell activation GO:0001774 9.7 TLR2 TLR6
21 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
22 complement activation, alternative pathway GO:0006957 9.7 C3 CFH
23 positive regulation of interleukin-12 production GO:0032735 9.7 CD40LG HSPD1 TLR2
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL1B TNF
25 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
26 negative regulation of lipid storage GO:0010888 9.69 IL6 TNF
27 positive regulation of interleukin-10 production GO:0032733 9.69 CD40LG HSPD1 TLR2
28 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
29 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.67 IL6 TNF
30 positive regulation of NF-kappaB import into nucleus GO:0042346 9.67 IL1B TLR2 TNF
31 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
32 regulation of immunoglobulin secretion GO:0051023 9.65 CD40LG TNF
33 positive regulation of interleukin-6 secretion GO:2000778 9.65 HSPD1 IL17A IL1B
34 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
35 cellular response to diacyl bacterial lipopeptide GO:0071726 9.64 TLR2 TLR6
36 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.63 TLR2 TLR6
37 positive regulation of chemokine production GO:0032722 9.63 IL6 TLR2 TNF
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF
39 cellular response to triacyl bacterial lipopeptide GO:0071727 9.61 TLR1 TLR2
40 cell activation GO:0001775 9.61 TLR1 TLR2 TLR6
41 immune response GO:0006955 9.61 C3 CD40LG IL17A IL1B IL6 TLR1
42 nitric oxide metabolic process GO:0046209 9.6 TLR2 TLR6
43 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.59 TLR1 TLR2
44 regulation of cytokine secretion GO:0050707 9.58 TLR1 TLR2 TLR6
45 detection of diacyl bacterial lipopeptide GO:0042496 9.57 TLR2 TLR6
46 detection of triacyl bacterial lipopeptide GO:0042495 9.56 TLR1 TLR2
47 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.56 HSPD1 TLR1 TLR2 TLR6
48 response to bacterial lipoprotein GO:0032493 9.55 TLR2 TLR6
49 positive regulation of interleukin-6 production GO:0032755 9.55 HSPD1 IL1B IL6 TLR2 TNF
50 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.5 IL1B TLR1 TLR6

Molecular functions related to Lyme Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 CD40LG IL17A IL1B IL6 TNF
2 Toll-like receptor 2 binding GO:0035663 9.16 TLR1 TLR6
3 lipopeptide binding GO:0071723 8.8 TLR1 TLR2 TLR6

Sources for Lyme Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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