MCID: LYM017
MIFTS: 64

Lyme Disease malady

Infectious diseases, Neuronal diseases, Rare diseases categories

Summaries for Lyme Disease

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Sources:
9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Lyme disease is a bacterial infection you get from the bite of an infected tick. the first symptom is usually a rash, which may look like a bull's eye. as the infection spreads, you may have a fever a headache muscle and joint aches a stiff neck fatigue lyme disease can be hard to diagnose because you may not have noticed a tick bite. also, many of its symptoms are like those of the flu and other diseases. in the early stages, your health care provider will look at your symptoms and medical history, to figure out whether you have lyme disease. lab tests may help at this stage, but may not always give a clear answer. in the later stages of the disease, a different lab test can confirm whether you have it. antibiotics can cure most cases of lyme disease. the sooner treatment begins, the quicker and more complete the recovery. after treatment, some patients may still have muscle or joint aches and nervous system symptoms. this is called post-lyme disease syndrome (plds). long-term antibiotics have not been shown to help with plds. however, there are ways to help with the symptoms of plds, and most patients do get better with time. nih: national institute of allergy and infectious diseases

MalaCards: Lyme Disease, also known as lyme neuroborreliosis, is related to thrombocytopenia and arthritis, and has symptoms including chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis, meningitis/meningeal syndrome and insomnia. An important gene associated with Lyme Disease is CD40LG (CD40 ligand), and among its related pathways are Malaria and Th17 Differentiation. The compounds pneumococcal and silicone have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and testes, and related mouse phenotypes are other and immune system.

Disease Ontology:9 A primary bacterial infectious disease that results in infection, has material basis in borrelia burgdorferi, which is transmitted by blacklegged tick (ixodes scapularis) or transmitted by western blacklegged tick (ixodes pacificus). the infection has symptom fever, has symptom headache, has symptom fatigue, and has symptom skin rash called erythema migrans. if left untreated, infection can spread to joints, the heart, and the nervous system.

CDC:4 Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected blacklegged ticks. Typical symptoms include fever, headache, fatigue, and a characteristic skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. Lyme disease is diagnosed based on symptoms, physical findings (e.g., rash), and the possibility of exposure to infected ticks; laboratory testing is helpful if used correctly and performed with validated methods. Most cases of Lyme disease can be treated successfully with a few weeks of antibiotics. Steps to prevent Lyme disease include using insect repellent, removing ticks promptly, applying pesticides, and reducing tick habitat. The ticks that transmit Lyme disease can occasionally transmit other tickborne diseases as well.

Wikipedia:66 Lyme disease (Lyme borreliosis) is an infectious disease caused by at least three species of bacteria... more...

Aliases & Classifications for Lyme Disease

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 50Orphanet, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 41NCIt, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
lyme disease:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

lyme disease 9 11 46 50 35 63
lyme neuroborreliosis 9 46 63
neuroborreliosis 9 63
lyme borreliosis 9 50
neurological lyme disease 9
bannworth's syndrome 9
bannwarth syndrome 9


External Ids:

Disease Ontology9 DOID:11729
MeSH36 D008193
ICD9CM28 088.81
NCIt41 C45161
MESH via Orphanet37 D008193
ICD10 via Orphanet27 A69.2
SNOMED-CT via Orphanet60 23502006
UMLS via Orphanet64 C0024198
ICD1026 A69.2

Related Diseases for Lyme Disease

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Lyme Disease:



Diseases related to lyme disease

Symptoms for Lyme Disease

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50Orphanet
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Symptoms:

50 (show all 32)
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • meningitis/meningeal syndrome
  • insomnia
  • fever
  • headache
  • fatigue
  • skin rash called erythema migrans
  • photophobia
  • skin hypoplasia/aplasia/atrophy
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • hydrarthrosis/articular/joint effusion
  • articular/joint pain/arthralgia
  • fever/chilling
  • cranial nerves palsy
  • asthenia/fatigue/weakness
  • arthritis/synovitis/synovial proliferation
  • psychic/behavioural troubles
  • muscle weakness/flaccidity
  • encephalitis
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • cardiac rhythm disorder/arrhythmia
  • cardiac conduction defect/sinoauricular/heart/auriculoventricular/branch block
  • transient amaurosis/acute visual trouble
  • facial pain/cephalalgia/migraine
  • troubles of memory/amnesia/hypermnesia
  • myalgia/muscular pain
  • peripheral neuropathy
  • follicular/erythematous/edematous papules/milium
  • macules
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • cutaneous rash
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Lyme Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Lyme Disease

Drug clinical trials:

Search ClinicalTrials for Lyme Disease

Search NIH Clinical Center for Lyme Disease

Search CenterWatch for Lyme Disease

Genetic Tests for Lyme Disease

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Anatomical Context for Lyme Disease

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34MalaCards
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MalaCards organs/tissues related to Lyme Disease:

34
Heart, Skin, Testes, Eye, Brain, Endothelial, B cells, T cells, Spinal cord, Liver, Salivary gland, Kidney, Whole blood, Breast, Retina

Animal Models for Lyme Disease or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Lyme Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.9CD40LG, CFH, TLR2
2MP:00053877.7CD40LG, CIITA, CFH, TLR1, TLR2
3MP:00053977.4TLR2, TLR1, CFH, CIITA, CD40LG

Publications for Lyme Disease

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Sources:
53PubMed
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Articles related to Lyme Disease:

(show top 50)    (show all 623)
idTitleAuthorsYear
1
Integrated assessment of behavioral and environmental risk factors for lyme disease infection on block island, rhode island. (24416278)
2014
2
Increased IFNI+ activity and differential antibody response in patients with a history of Lyme disease and persistent cognitive deficits. (23141748)
2013
3
Distribution of cp32 prophages among Lyme disease-causing spirochetes and natural diversity of their lipoprotein-encoding erp loci. (23624478)
2013
4
Potential role of deer tick virus in Powassan encephalitis cases in Lyme disease-endemic areas of New York, U.S.A. (24274334)
2013
5
Multi-criteria decision analysis as an innovative approach to managing zoonoses: results from a study on Lyme disease in Canada. (24079303)
2013
6
The Lyme disease debate: host biodiversity and human disease risk. (23548684)
2013
7
Reductions in human Lyme disease risk due to the effects of oral vaccination on tick-to-mouse and mouse-to-tick transmission. (23428088)
2013
8
Bull's eye! Lyme disease awareness. (24137697)
2013
9
Does high biodiversity reduce the risk of Lyme disease invasion? (23816142)
2013
10
Lyme disease--unusual medical encounter for an urologist. (23700896)
2012
11
What do we need to know about disease ecology to prevent Lyme disease in the northeastern United States? (22308766)
2012
12
A single-domain FlgJ contributes to flagellar hook and filament formation in the Lyme disease spirochete Borrelia burgdorferi. (22155773)
2012
13
Lyme disease: knowledge, beliefs, and practices of physicians in a low-endemic area. (22734172)
2012
14
Neurogenic bladder in lyme disease. (23346488)
2012
15
Lyme disease. (22608120)
2012
16
Lyme disease presenting as ptosis, conjunctivitis, and photophobia. (21224251)
2012
17
Diagnosis and management of Lyme disease. (22962880)
2012
18
Probable late lyme disease: a variant manifestation of untreated Borrelia burgdorferi infection. (22853630)
2012
19
Canine serology as adjunct to human Lyme disease surveillance. (21888800)
2011
20
Lyme disease enolpyruvyl-UDP-GlcNAc synthase: fosfomycin-resistant MurA from Borrelia burgdorferi, a fosfomycin-sensitive mutant, and the catalytic role of the active site Asp. (21294548)
2011
21
Pervasive recombination and sympatric genome diversification driven by frequency-dependent selection in Borrelia burgdorferi, the Lyme disease bacterium. (21890743)
2011
22
The pain of chronic Lyme disease: moving the discourse backward? (22131364)
2011
23
Tick saliva represses innate immunity and cutaneous inflammation in a murine model of Lyme disease. (21612525)
2011
24
Sympathetic neural hyperalgesia edema syndrome, a frequent cause of pelvic pain in women, mistaken for Lyme disease with chronic fatigue. (22268288)
2011
25
Borrelia burgdorferi RST1 (OspC type A) genotype is associated with greater inflammation and more severe Lyme disease. (21641395)
2011
26
Differential risk for Lyme disease along hiking trail, Germany. (21888798)
2011
27
Trial of a minimal-risk botanical compound to control the vector tick of Lyme disease. (20695287)
2010
28
Invasion of the lyme disease vector Ixodes scapularis: implications for Borrelia burgdorferi endemicity. (20229127)
2010
29
The utility of "Google Trends" for epidemiological research: Lyme disease as an example. (20503183)
2010
30
The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete. (19906179)
2009
31
Hosts as ecological traps for the vector of Lyme disease. (19692412)
2009
32
Successful desensitisation to ceftriaxone in a patient with doxycicline resistant Lyme disease. (19445868)
2009
33
NerveCenter: Guideline-making gets tougher: action by state attorney general over Lyme disease guidelines stirs debate. (19334071)
2009
34
Complement split products c3a and c4a in chronic lyme disease. (19140878)
2009
35
Community-based prevention of Lyme disease and other tick-borne diseases through topical application of acaricide to white-tailed deer: background and rationale. (19650729)
2009
36
A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi. (19218460)
2009
37
Levels of sVCAM-1 and sICAM-1 in patients with lyme disease. (19413177)
2009
38
Neuroretinitis secondary to concurrent infection with cat scratch disease and lyme disease. (18791545)
2009
39
Significantly improved accuracy of diagnosis of early Lyme disease by peptide enzyme-linked immunosorbent assay based on the borreliacidal antibody epitope of Borrelia burgdorferi OspC. (18417666)
2008
40
Differential binding of host complement inhibitor factor H by Borrelia burgdorferi Erp surface proteins: a possible mechanism underlying the expansive host range of Lyme disease spirochetes. (11796574)
2002
41
Atypical erythema multiforme occurring at the early phase of Lyme disease? (10954224)
2000
42
Carbamazepine in the treatment of Lyme disease-induced hyperacusis. (9990563)
1999
43
Recurrent human granulocytic ehrlichiosis and Lyme disease. (10383360)
1999
44
Lyme disease and human granulocytic ehrlichiosis. (9322603)
1997
45
A monoclonal antibody to Borrelia burgdorferi flagellin modifies neuroblastoma cell neuritogenesis in vitro: a possible role for autoimmunity in the neuropathy of Lyme disease. (9125553)
1997
46
Uptake and killing of Lyme disease and relapsing fever borreliae in the perfused rat liver and by isolated Kupffer cells. (8613404)
1996
47
Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. (8551229)
1996
48
Establishment of enzyme-linked immunosorbent assay using purified recombinant 83-kilodalton antigen of Borrelia burgdorferi sensu stricto and Borrelia afzelii for serodiagnosis of Lyme disease. (8567889)
1995
49
Immune recognition of human Hsp60 by Lyme disease patient sera. (8100982)
1993
50
Iritis and papillitis as a primary presentation of Lyme disease. (2310116)
1990

Variations for Lyme Disease

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Expression for genes affiliated with Lyme Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lyme Disease

Search GEO for disease gene expression data for Lyme Disease.

Pathways for genes affiliated with Lyme Disease

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Sources:
51PathCards, 31KEGG, 55R&D Systems, 54QIAGEN, 62Tocris Bioscience, 5Cell Signaling Technology, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 58SinoBiological
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Pathways related to Lyme Disease according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TLR2, CD40LG
2
Show member pathways
9.4TLR2, TLR1
39.4TLR1, TLR2
4
Show member pathways
9.4TLR1, TLR2
59.4TLR1, TLR2
6
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.4TLR1, TLR2
7
Show member pathways
IL27-mediated signaling events39
9.4TLR1, TLR2
8
Show member pathways
9.4TLR1, TLR2
99.3HSPA8, TLR2
109.3CD40LG, CIITA
11
Show member pathways
9.0CD40LG, TLR1, TLR2
12
Show member pathways
8.8CD40LG, CIITA, HSPA8
138.6TLR2, TLR1, CIITA
14
Show member pathways
8.5TLR2, HSPA8, CIITA
15
Show member pathways
8.1CD40LG, CIITA, HSPA8, TLR2

Compounds for genes affiliated with Lyme Disease

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 52PharmGKB
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Compounds related to Lyme Disease according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1pneumococcal4610.0CD40LG, CFH
2silicone469.9CD40LG, HSPA8
3glucuronoxylomannan469.9TLR2, CD40LG
4cardiolipin46 1210.9CD40LG, CFH
5mannan469.8CD40LG, TLR2
6pam2csk4629.8TLR2, TLR1
7pam3csk4629.8TLR2, TLR1
8poly(i:c)629.8TLR2, TLR1
9resiquimod46 6210.8TLR1, TLR2
10flagellin46 3010.8TLR2, TLR1
11imiquimod46 62 30 1212.8TLR2, TLR1
12lipoteichoic acid469.7TLR1, TLR2
13anti-fungal469.7CD40LG, TLR2
14theophylline46 30 25 1212.7CD40LG, HSPA8
15mannitol46 1210.5CD40LG, HSPA8
16dextran sulfate469.5CD40LG, CIITA
17enterotoxin469.4TLR2, CIITA
18ganglioside469.3CD40LG, CIITA
19deoxyribonucleic acid469.3CIITA, HSPA8
20polyinosinic-polycytidylic acid469.3CIITA, TLR2
21polysaccharide469.3CD40LG, CFH, TLR2
22fibrinogen469.3CD40LG, CFH, TLR2
23cisplatin46 52 62 1212.2CFH, HSPA8, CD40LG
24allergens469.2CD40LG, CIITA, HSPA8
25heparin46 30 25 1212.1CFH, CFHR1, HSPA8, CD40LG
26dopamine46 30 25 1212.0HSPA8, CIITA, CD40LG
27actinomycin d469.0TLR2, CIITA, CD40LG
28simvastatin46 52 62 30 25 1213.9TLR2, HSPA8, CIITA
29ribonucleic acid468.9CIITA, HSPA8, TLR2
30hydrogen46 259.8CIITA, HSPA8, TLR2
31vegf468.7TLR2, HSPA8, CD40LG
32zinc46 259.6CIITA, HSPA8, CFH
33endotoxin468.6CD40LG, CIITA, HSPA8, TLR2
34rantes468.6TLR2, HSPA8, CIITA, CD40LG
35pge2468.6TLR2, HSPA8, CIITA, CD40LG
36dexamethasone46 52 30 1211.5CD40LG, CIITA, CFH, TLR2
37peptidoglycan46 309.5CIITA, HSPA8, TLR1, TLR2
38cholesterol46 30 25 1211.4TLR2, CFH, HSPA8, CIITA
39glucose468.3TLR2, CFH, HSPA8, CIITA
40lipid468.3TLR2, TLR1, HSPA8, CIITA
41cyclosporin a46 30 6210.1TLR2, CFH, HSPA8, CIITA, CD40LG
42alanine468.0CD40LG, CIITA, HSPA8, CFH, TLR2
43cysteine468.0TLR2, CFH, HSPA8, CIITA, CD40LG
44serine468.0CD40LG, CIITA, HSPA8, CFH, TLR2
45tyrosine468.0TLR2, CFH, HSPA8, CIITA

GO Terms for genes affiliated with Lyme Disease

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17Gene Ontology
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Cellular components related to Lyme Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:0353549.1TLR1, TLR2
2blood microparticleGO:0725629.0HSPA8, CFHR1, CFH

Biological processes related to Lyme Disease according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cellular response to triacyl bacterial lipopeptideGO:0717279.6TLR1, TLR2
2detection of triacyl bacterial lipopeptideGO:0424959.5TLR1, TLR2
3positive regulation of interleukin-12 productionGO:0327359.5TLR2, CD40LG
4positive regulation of tumor necrosis factor biosynthetic processGO:0425359.5TLR1, TLR2
5complement activationGO:0069569.4CFH, CFHR1
6toll-like receptor signaling pathwayGO:0022249.4TLR1, TLR2
7innate immune responseGO:0450878.6CFH, TLR1, TLR2
8immune responseGO:0069558.6CIITA, TLR1, TLR2
9inflammatory responseGO:0069548.4TLR2, TLR1, CIITA, CD40LG

Molecular functions related to Lyme Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.4TLR1, TLR2

Products for genes affiliated with Lyme Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lyme Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet