MCID: LYM017
MIFTS: 62

Lyme Disease malady

Infectious, Neuronal categories

Summaries for Lyme Disease

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Lyme disease is a bacterial infection you get from the bite of an infected tick. the first symptom is usually a rash, which may look like a bull's eye. as the infection spreads, you may have a fever a headache muscle and joint aches a stiff neck fatigue lyme disease can be hard to diagnose because you may not have noticed a tick bite. also, many of its symptoms are like those of the flu and other diseases. in the early stages, your health care provider will look at your symptoms and medical history, to figure out whether you have lyme disease. lab tests may help at this stage, but may not always give a clear answer. in the later stages of the disease, a different lab test can confirm whether you have it. antibiotics can cure most cases of lyme disease. the sooner treatment begins, the quicker and more complete the recovery. after treatment, some patients may still have muscle or joint aches and nervous system symptoms. this is called post-lyme disease syndrome (plds). long-term antibiotics have not been shown to help with plds. however, there are ways to help with the symptoms of plds, and most patients do get better with time. nih: national institute of allergy and infectious diseases

MalaCards: Lyme Disease, also known as lyme neuroborreliosis, is related to arthritis and thrombocytopenia, and has symptoms including nausea/vomiting/regurgitation/merycism/hyperemesis, encephalitis and muscle weakness/flaccidity. An important gene associated with Lyme Disease is CD40LG (CD40 ligand), and among its related pathways are Th17 Differentiation and NF-kappaB Signaling. The compounds cycloheximide and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A primary bacterial infectious disease that results in infection, has material basis in borrelia burgdorferi, which is transmitted by blacklegged tick (ixodes scapularis) or transmitted by western blacklegged tick (ixodes pacificus). the infection has symptom fever, has symptom headache, has symptom fatigue, and has symptom skin rash called erythema migrans. if left untreated, infection can spread to joints, the heart, and the nervous system.

CDC:3 Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected blacklegged ticks. Typical symptoms include fever, headache, fatigue, and a characteristic skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. Lyme disease is diagnosed based on symptoms, physical findings (e.g., rash), and the possibility of exposure to infected ticks; laboratory testing is helpful if used correctly and performed with validated methods. Most cases of Lyme disease can be treated successfully with a few weeks of antibiotics. Steps to prevent Lyme disease include using insect repellent, removing ticks promptly, applying pesticides, and reducing tick habitat. The ticks that transmit Lyme disease can occasionally transmit other tickborne diseases as well.

Wikipedia:64 Lyme disease (Lyme borreliosis) is an infectious disease caused by at least three species of bacteria... more...

Aliases & Classifications for Lyme Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
lyme disease:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

lyme disease 8 10 45 49 34 61
lyme neuroborreliosis 8 45 61
neuroborreliosis 8 61
lyme borreliosis 8 49
neurological lyme disease 8
bannworth's syndrome 8
bannwarth syndrome 8


External Ids:

Disease Ontology8 DOID:11729
NCIt40 C45161
ICD9CM27 088.81
MeSH35 D008193
MESH via Orphanet36 D008193
ICD10 via Orphanet26 A69.2
SNOMED-CT via Orphanet58 23502006
UMLS via Orphanet62 C0024198
ICD1025 A69.2

Related Diseases for Lyme Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Lyme Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.6HSPA8, CCL4, CCL3, TLR2, CIITA, CLDN11
2thrombocytopenia30.6NFE2, CD40LG, CFH
3amyotrophic lateral sclerosis30.2GPR162
4tuberculosis30.2HSPA8, CCL4, CCL3, TLR2, TLR1, MBP
5vasculitis30.1CD40LG
6toxoplasmosis29.9CD40LG
7uveitis29.9CCL4
8systemic lupus erythematosus29.9CCL4, CCL3, TLR2, TLR7, CIITA, CD40LG
9tropical spastic paraparesis29.9CCL3, MBP
10spirochetes disease10.7
11babesiosis10.6
12leukopenia10.4
13spotted fever10.4
14human granulocytic anaplasmosis10.4
15rocky mountain spotted fever10.4
16lyme disease - neurological complications10.4
17retinal vasculitis10.3
18myelitis10.3
19pseudotumor cerebri10.3
20sensorineural hearing loss10.3
21syphilis10.3
22transverse myelitis10.3
23acrodermatitis10.3
24ataxia10.3
25lip disease10.3
26neuroretinitis10.2
27n syndrome10.2
28brain disease10.2
29chronic pain10.2
30bacteremia10.2
31rheumatic disease10.2
32acute transverse myelitis10.2
33nephropathia epidemica10.2
34nonparalytic poliomyelitis10.2
35botulism10.2
36turner syndrome10.2
37parsonage turner syndrome10.2
38primary effusion lymphoma10.2
39birdshot chorioretinopathy10.2
40cogan's syndrome10.2
41complement component deficiency10.2
42coronary artery aneurysm10.2
43juvenile scleroderma10.2
44splenomegaly10.2
45idiopathic facial palsy10.2
46lateral sclerosis10.1
47erythema multiforme10.1
48choroiditis10.1
49pars planitis10.1
50granulomatous hepatitis10.1

Graphical network of the top 20 diseases related to Lyme Disease:



Diseases related to lyme disease

Clinical Features for Lyme Disease

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 32)
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • encephalitis
  • muscle weakness/flaccidity
  • psychic/behavioural troubles
  • arthritis/synovitis/synovial proliferation
  • photophobia
  • asthenia/fatigue/weakness
  • cranial nerves palsy
  • fever/chilling
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • cardiac rhythm disorder/arrhythmia
  • cardiac conduction defect/sinoauricular/heart/auriculoventricular/branch block
  • cutaneous rash
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • follicular/erythematous/edematous papules/milium
  • peripheral neuropathy
  • myalgia/muscular pain
  • troubles of memory/amnesia/hypermnesia
  • facial pain/cephalalgia/migraine
  • transient amaurosis/acute visual trouble
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • skin hypoplasia/aplasia/atrophy
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • meningitis/meningeal syndrome
  • insomnia
  • fever
  • headache
  • fatigue
  • skin rash called erythema migrans

Drugs & Therapeutics for Lyme Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lyme Disease

Drug clinical trials:

Search ClinicalTrials for Lyme Disease

Search NIH Clinical Center for Lyme Disease

Search CenterWatch for Lyme Disease

Genetic Tests for Lyme Disease

Anatomical Context for Lyme Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Lyme Disease:

33
Skin, Liver, Spinal cord, Brain, Kidney, Whole blood, Retina, Heart, Salivary gland, Breast, T cells, B cells, Endothelial

Animal Models for Lyme Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Lyme Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.9TLR2, TLR7, MBP, CIITA, NFE2, MAFK
2MP:00053879.5CFH, CCL3, TLR2, TLR7, TLR1, MBP

Publications for Lyme Disease

Sources:
51PubMed
See all sources

Articles related to Lyme Disease:

(show top 50)    (show all 640)
idTitleAuthorsYear
1
Effects of Landscape Fragmentation and Climate on Lyme Disease Incidence in the Northeastern United States. (24419663)
2014
2
Distribution of cp32 prophages among Lyme disease-causing spirochetes and natural diversity of their lipoprotein-encoding erp loci. (23624478)
2013
3
Potential role of deer tick virus in Powassan encephalitis cases in Lyme disease-endemic areas of New York, U.S.A. (24274334)
2013
4
Suggested role for G4 DNA in recombinational switching at the antigenic variation locus of the Lyme disease spirochete. (23469068)
2013
5
Rapid progressive bilateral hearing loss due to granulomatous otitis media in Lyme disease. (23313123)
2013
6
White-tailed deer (Odocoileus virginianus) as a potential sentinel for human Lyme disease in Indiana. (22776734)
2013
7
Reinfection versus relapse in Lyme disease. (23495391)
2013
8
Feeding of ticks on animals for transmission and xenodiagnosis in Lyme disease research. (24022694)
2013
9
Bpur, the Lyme disease spirochete's PUR domain protein: identification as a transcriptional modulator and characterization of nucleic acid interactions. (23846702)
2013
10
Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease. (23062467)
2013
11
A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease. (23044924)
2013
12
Lyme disease: knowledge, beliefs, and practices of physicians in a low-endemic area. (22734172)
2012
13
Lyme disease presenting as ptosis, conjunctivitis, and photophobia. (21224251)
2012
14
Consequences of landscape fragmentation on Lyme disease risk: a cellular automata approach. (22761842)
2012
15
BpaB and EbfC DNA-binding proteins regulate production of the Lyme disease spirochete's infection-associated Erp surface proteins. (22155777)
2012
16
Direct molecular detection and genotyping of Borrelia burgdorferi from whole blood of patients with early Lyme disease. (22590620)
2012
17
SPECT brain imaging in chronic Lyme disease. (22889796)
2012
18
Seroprevalence of Lyme disease and genospecies of Borrelia burgdorferi sensu lato in patients diagnosed with borreliosis in the Province of Warmia-Masuria in north-eastern Poland. (22742788)
2012
19
A possible role for inflammation in mediating apoptosis of oligodendrocytes as induced by the Lyme disease spirochete Borrelia burgdorferi. (22524232)
2012
20
Diastolic heart murmur, nocturnal back pain, and lumbar rigidity in a 7-year girl: an unusual manifestation of lyme disease in childhood. (23056982)
2012
21
Cure unwanted? Exploring the chronic Lyme disease controversy and why conflicts of interest in practice guidelines may be guiding us down the wrong path. (22497097)
2012
22
Tick saliva represses innate immunity and cutaneous inflammation in a murine model of Lyme disease. (21612525)
2011
23
Lyme disease and the heart in the UK. (22083002)
2011
24
Multiplex immunoassay for Lyme disease using VlsE1-IgG and pepC10-IgM antibodies: improving test performance through bioinformatics. (21367982)
2011
25
Lyme disease: Part I. Advances and perspectives. (21414493)
2011
26
A case revealing the natural history of untreated Lyme disease. (21173795)
2011
27
Lyme disease and climate change. (20486310)
2010
28
Tracking the deer tick: emerging lyme disease threat in Canada. (20601318)
2010
29
Detection of Lyme disease spirochete, Borrelia burgdorferi sensu lato, including three novel genotypes in ticks (Acari: Ixodidae) collected from songbirds (Passeriformes) across Canada. (20618658)
2010
30
2-tiered antibody testing for early and late Lyme disease using only an immunoglobulin G blot with the addition of a VlsE band as the second-tier test. (19947857)
2010
31
Elimination of lyme disease spirochetes from ticks feeding on domestic ruminants. (20870789)
2010
32
Final report of the Lyme disease review panel of the infectious diseases society of america: a pyrrhic victory? (20925511)
2010
33
Identification and function of the RNA chaperone Hfq in the Lyme disease spirochete Borrelia burgdorferi. (20815822)
2010
34
Levels of sVCAM-1 and sICAM-1 in patients with lyme disease. (19413177)
2009
35
Five cases of paralytic strabismus as a rare feature of lyme disease. (19193112)
2009
36
Small fiber neuropathy following vaccination for rabies, varicella or Lyme disease. (19808027)
2009
37
High-throughput screening identifies three inhibitor classes of the telomere resolvase from the lyme disease spirochete. (19596868)
2009
38
Acaricidal treatment of white-tailed deer to control Ixodes scapularis (Acari: Ixodidae) in a New York Lyme disease-endemic community. (19650732)
2009
39
Re: A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy. Prolonged Lyme disease treatment: enough is enough. (19180683)
2009
40
The relapsing fever spirochete Borrelia hermsii contains multiple, antigen-encoding circular plasmids that are homologous to the cp32 plasmids of Lyme disease spirochetes. (10858201)
2000
41
Carbamazepine in the treatment of Lyme disease-induced hyperacusis. (9990563)
1999
42
Coinfection of blacklegged ticks (Acari: Ixodidae) in Dutchess County, New York, with the agents of Lyme disease and human granulocytic ehrlichiosis. (9775627)
1998
43
Deer ticks (Ixodes scapularis) and the agents of Lyme disease and human granulocytic ehrlichiosis in a New York City park. (9284380)
1997
44
Detection of Borrelia burgdorferi DNA and complement membrane attack complex deposits in the sural nerve of a patient with chronic polyneuropathy and tertiary Lyme disease. (9236787)
1997
45
Rocky Mountain spotted fever versus Lyme disease. (7839177)
1995
46
Lyme disease, Rocky Mountain spotted fever, ehrlichiosis: emerging and established challenges for the clinician. (8030801)
1994
47
The risk of acquiring Lyme disease or babesiosis from a blood transfusion. (8014507)
1994
48
Monolateral chorioretinitis with multiple foci in one case of Lyme disease. (8363293)
1993
49
Iritis and papillitis as a primary presentation of Lyme disease. (2310116)
1990
50
Late cutaneous Lyme disease: acrodermatitis chronica atrophicans. (2729343)
1989

Genetic Variations for Lyme Disease

Expression for genes affiliated with Lyme Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lyme Disease

Search GEO for disease gene expression data for Lyme Disease.

Pathways for genes affiliated with Lyme Disease

Sources:
53R&D Systems, 4Cell Signaling Technology, 54Reactome, 60Tocris Bioscience, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 56SinoBiological, 30KEGG
See all sources

Pathways related to Lyme Disease according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4TLR1, TLR7
210.3TLR1, TLR7, TLR2
3
Hide members
10.3TLR1, TLR7, TLR2
410.3TLR1, TLR7, TLR2
510.3TLR2, TLR7, TLR1
610.3TLR2, TLR7, TLR1
7
Hide members
10.3TLR2, TLR7, TLR1
8
Hide members
10.3TLR2, TLR7, TLR1, CD40LG
9
Hide members
10.3CD40LG, CIITA, TLR2, HSPA8
10
Hide members
10.2CIITA, TLR7, TLR2, HSPA8
11
Hide members
10.2TLR1, TLR7, TLR2, CCL3, CCL4
12
Hide members
10.2CCL4, CCL3, TLR2, TLR7, TLR1

Compounds for genes affiliated with Lyme Disease

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Lyme Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.8TLR2
2endotoxin4510.8CIITA, HSPA8
3pam2csk46010.7TLR2, TLR7, TLR1
4pam3csk46010.7TLR2, TLR7, TLR1
5poly(i:c)6010.7TLR2, TLR7, TLR1
6resiquimod45 6011.7TLR1, TLR7, TLR2
7loxoribine45 2911.7TLR7, TLR2
8imiquimod45 29 60 1113.7TLR1, TLR7, TLR2
9glucuronoxylomannan4510.7TLR2, CD40LG
10toxin-14510.7CCL4, CCL3, CIITA
11mdms4510.7CCL4, CCL3, CIITA
12lipoteichoic acid4510.7CCL3, TLR2, TLR7, TLR1
13indomethacin45 60 29 1113.7MBP
14polyinosinic-polycytidylic acid4510.7CCL3, TLR2, TLR7, CIITA
15poly(i-c)4510.7CCL3, TLR2, TLR7
16allergens4510.7CD40LG, CIITA, CCL4, HSPA8
17tacrolimus45 50 1112.6TLR2, CCL3, CCL4
18il 104510.6CCL4, CCL3, TLR2
19ivig4510.6CCL4, MBP, CD40LG
20cefotaxime45 1111.6LACTB, TLR2
21dexamethasone45 50 29 1113.6CFH, CD40LG, CIITA, TLR2
22ccl345 2911.6TLR2, CCL3, CCL4
23ionomycin4510.6CCL4, CCL3, TLR2, CD40LG
24heparin45 29 11 2413.6HSPA8, CCL4, CCL3, CD40LG, CFHR1
25ccl445 2911.6TLR2, CCL3, CCL4
26vancomycin45 1111.6LACTB, CD40LG
27ganglioside4510.6CD40LG, CIITA, MBP
28simvastatin45 50 60 29 11 2415.6HSPA8, CCL4, CCL3, TLR2, CIITA
29pneumococcal4510.6CD40LG, CFH
30polysaccharide4510.6CCL4, CCL3, TLR2, CD40LG, CFH
31isopentenyl diphosphate45 2911.6CCL4, CCL3
32rantes4510.6HSPA8, CCL4, CCL3, TLR2, CIITA, CD40LG
33actinomycin d4510.5CCL3, TLR2, CIITA, NFE2, CD40LG
34hydroxychloroquine45 1111.5CD40LG, TLR7
35ribonucleic acid4510.5HSPA8, CCL3, TLR2, CIITA
36peptidoglycan45 2911.5CIITA, HSPA8, CCL4, CCL3, TLR2, TLR7
37serine4510.5HSPA8, CCL4, CCL3, TLR2, CIITA, LACTB
38cholesterol45 29 11 2413.5HSPA8, CCL4, CCL3, TLR2, CIITA, CFH
39teck4510.5CCL3, CCL4
40leucine4510.4CCL3, TLR2, CIITA, NFE2, MAFK
41cyclosporin a45 29 6012.4HSPA8, CCL4, CCL3, TLR2, MBP, CIITA
42alanine4510.4HSPA8, CCL4, CCL3, TLR2, MBP, CIITA
43mcp 14510.4CCL4, CCL3
44cysteine4510.4HSPA8, CCL4, CCL3, TLR2, MBP, CIITA
45retinoic acid45 2411.4CFH, CCL4, CCL3, TLR2, MBP, CD40LG
46histamine45 29 2412.3CCL4, CCL3, TLR2, CD40LG
472,3-cyclic nucleotide4510.3MBP, CLDN11
48amoxicillin45 50 1112.3CD40LG, LACTB
49steroid4510.1CCL4, CCL3, CIITA, NFE2, HSPA8
50mip 1alpha4510.0CCL3, CCL4

GO Terms for genes affiliated with Lyme Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Lyme Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.4TLR1, TLR2

Biological processes related to Lyme Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cellular response to triacyl bacterial lipopeptideGO:07172710.6TLR2, TLR1
2detection of triacyl bacterial lipopeptideGO:04249510.6TLR2, TLR1
3detection of diacyl bacterial lipopeptideGO:04249610.6TLR1, TLR2
4positive regulation of natural killer cell chemotaxisGO:200050310.5CCL3, CCL4
5positive regulation of inflammatory responseGO:05072910.5CCL3, TLR2, TLR7
6axon ensheathmentGO:00836610.5CLDN11, MBP
7positive regulation of tumor necrosis factor biosynthetic processGO:04253510.4TLR2, TLR1
8inflammatory responseGO:00695410.4CD40LG, TLR1, TLR7, TLR2, CCL3, CCL4
9response to toxic substanceGO:00963610.4MBP, CCL3, CCL4
10I-kappaB phosphorylationGO:00725210.4TLR7, TLR2
11positive regulation of chemokine productionGO:03272210.4TLR7, TLR2
12immune responseGO:00695510.4CCL4, TLR2, TLR1, MBP, CIITA, SP2
13negative regulation by host of viral transcriptionGO:04392210.2CCL3, CCL4
14negative regulation of bone mineralizationGO:03050210.0NFE2, CCL3

Molecular functions related to Lyme Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR1 chemokine receptor bindingGO:03172610.3CCL3, CCL4
2CCR5 chemokine receptor bindingGO:03173010.0CCL3, CCL4

Products for genes affiliated with Lyme Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lyme Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet