MCID: LYM017
MIFTS: 65

Lyme Disease malady

Infectious diseases, Neuronal diseases, Rare diseases categories

Summaries for Lyme Disease

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MedlinePlus:33 Lyme disease is a bacterial infection you get from the bite of an infected tick. the first symptom is usually a rash, which may look like a bull's eye. as the infection spreads, you may have a fever a headache muscle and joint aches a stiff neck fatigue lyme disease can be hard to diagnose because you may not have noticed a tick bite. also, many of its symptoms are like those of the flu and other diseases. in the early stages, your health care provider will look at your symptoms and medical history, to figure out whether you have lyme disease. lab tests may help at this stage, but may not always give a clear answer. in the later stages of the disease, a different lab test can confirm whether you have it. antibiotics can cure most cases of lyme disease. the sooner treatment begins, the quicker and more complete the recovery. after treatment, some patients may still have muscle or joint aches and nervous system symptoms. this is called post-lyme disease syndrome (plds). long-term antibiotics have not been shown to help with plds. however, there are ways to help with the symptoms of plds, and most patients do get better with time. nih: national institute of allergy and infectious diseases

MalaCards based summary: Lyme Disease, also known as lyme neuroborreliosis, is related to thrombocytopenia and scrub typhus, and has symptoms including hypermelanotic macule, meningitis and arthritis. An important gene associated with Lyme Disease is CD40LG (CD40 ligand), and among its related pathways are Malaria and Th17 Differentiation. The compounds pneumococcal and silicone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and skin, and related mouse phenotypes are other and immune system.

Disease Ontology:9 A primary bacterial infectious disease that results in infection, has material basis in borrelia burgdorferi, which is transmitted by blacklegged tick (ixodes scapularis) or transmitted by western blacklegged tick (ixodes pacificus). the infection has symptom fever, has symptom headache, has symptom fatigue, and has symptom skin rash called erythema migrans. if left untreated, infection can spread to joints, the heart, and the nervous system.

CDC:4 Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected blacklegged ticks. Typical symptoms include fever, headache, fatigue, and a characteristic skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. Lyme disease is diagnosed based on symptoms, physical findings (e.g., rash), and the possibility of exposure to infected ticks; laboratory testing is helpful if used correctly and performed with validated methods. Most cases of Lyme disease can be treated successfully with a few weeks of antibiotics. Steps to prevent Lyme disease include using insect repellent, removing ticks promptly, applying pesticides, and reducing tick habitat. The ticks that transmit Lyme disease can occasionally transmit other tickborne diseases as well.

Wikipedia:64 Lyme disease (Lyme borreliosis) is an infectious disease caused by at least three species of bacteria... more...

Aliases & Classifications for Lyme Disease

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Sources:
9Disease Ontology, 11DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 61UMLS, 56SNOMED-CT, 39NCIt, 28ICD9CM, 34MeSH, 35MESH via Orphanet, 27ICD10 via Orphanet, 62UMLS via Orphanet, 26ICD10
See all sources

Lyme Disease, Aliases & Descriptions:

Name: Lyme Disease 9 11 44 48 33 61
Lyme Neuroborreliosis 9 44 61
Lyme Borreliosis 9 48 61
Neurological Lyme Disease 9 61
 
Neuroborreliosis 9 61
Bannworth's Syndrome 9
Bannwarth Syndrome 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
lyme disease:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

Disease Ontology9 DOID:11729
NCIt39 C45161
ICD9CM28 088.81
MeSH34 D008193
MESH via Orphanet35 D008193
ICD10 via Orphanet27 A69.2
UMLS via Orphanet62 C0024198
ICD1026 A69.2

Related Diseases for Lyme Disease

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Diseases related to Lyme Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia30.7CD40LG, CFH
2scrub typhus30.6CD40LG
3toxoplasmosis30.6CD40LG
4encephalitis30.4TLR2, CIITA
5glomerulonephritis30.2CD40LG, CFH
6arthritis30.1TLR2, HSPA8, CIITA
7tuberculosis29.5TLR2, TLR1, CIITA, HSPA8
8systemic lupus erythematosus29.3CD40LG, CIITA, CFH, TLR2
9ehrlichiosis10.6
10babesiosis10.5
11relapsing fever10.5
12primary immunodeficiency disease10.5CD40LG
13poliomyelitis10.4
14leukopenia10.4
15complement factor h deficiency10.4CFH
16atypical hemolytic-uremic syndrome10.4CFH
17spotted fever10.4
18retinal vasculitis10.4
19vasculitis10.4
20leprosy10.3TLR2
21human granulocytic anaplasmosis10.3
22rocky mountain spotted fever10.3
23lyme disease - neurological complications10.3
24viral hepatitis10.3TLR2
25myelitis10.3
26sensorineural hearing loss10.3
27pseudotumor cerebri10.3
28neuropathy10.3
29syphilis10.3
30transverse myelitis10.3
31acrodermatitis10.2
32ataxia10.2
33hemolytic-uremic syndrome10.2CFH, CFHR1
34ankylosing spondylitis10.2HSPA8, CD40LG
35hydrocephalus10.2
36normal pressure hydrocephalus10.2
37alexithymia10.2
38dementia10.2
39propriospinal myoclonus10.2
40syndrome of inappropriate antidiuretic hormone10.2
41myoclonus10.2
42antiphospholipid syndrome10.2CD40LG, CFH
43nephropathia epidemica10.2
44nonparalytic poliomyelitis10.2
45c3 deficiency10.2
46botulism10.2
47brucellosis10.2
48legionellosis10.2
49pertussis10.2
50turner syndrome10.2

Graphical network of the top 20 diseases related to Lyme Disease:



Diseases related to lyme disease

Symptoms for Lyme Disease

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Symptoms:

 48 9 (show all 32)
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • follicular/erythematous/edematous papules/milium
  • cranial nerves palsy
  • meningitis/meningeal syndrome
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • transient amaurosis/acute visual trouble
  • photophobia
  • skin hypoplasia/aplasia/atrophy
  • cutaneous rash
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • cardiac rhythm disorder/arrhythmia
  • cardiac conduction defect/sinoauricular/heart/auriculoventricular/branch block
  • peripheral neuropathy
  • facial pain/cephalalgia/migraine
  • encephalitis
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • insomnia
  • troubles of memory/amnesia/hypermnesia
  • psychic/behavioural troubles
  • muscle weakness/flaccidity
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • fever/chilling
  • asthenia/fatigue/weakness
  • fever
  • headache
  • fatigue
  • skin rash called erythema migrans

HPO human phenotypes related to Lyme Disease:

(show all 21)
id Description Frequency HPO Source Accession
1 hypermelanotic macule hallmark (90%) HP:0001034
2 meningitis typical (50%) HP:0001287
3 arthritis typical (50%) HP:0001369
4 joint swelling typical (50%) HP:0001386
5 cranial nerve paralysis typical (50%) HP:0006824
6 photophobia occasional (7.5%) HP:0000613
7 skin rash occasional (7.5%) HP:0000988
8 muscle weakness occasional (7.5%) HP:0001324
9 nausea and vomiting occasional (7.5%) HP:0002017
10 migraine occasional (7.5%) HP:0002076
11 memory impairment occasional (7.5%) HP:0002354
12 encephalitis occasional (7.5%) HP:0002383
13 arthralgia occasional (7.5%) HP:0002829
14 myalgia occasional (7.5%) HP:0003326
15 paresthesia occasional (7.5%) HP:0003401
16 abnormality of temperature regulation occasional (7.5%) HP:0004370
17 aplasia/hypoplasia of the skin occasional (7.5%) HP:0008065
18 arrhythmia occasional (7.5%) HP:0011675
19 inflammatory abnormality of the eye occasional (7.5%) HP:0100533
20 amaurosis fugax occasional (7.5%) HP:0100576
21 insomnia occasional (7.5%) HP:0100785

Drugs & Therapeutics for Lyme Disease

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Drug clinical trials:

Search ClinicalTrials for Lyme Disease

Search NIH Clinical Center for Lyme Disease

Genetic Tests for Lyme Disease

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Anatomical Context for Lyme Disease

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MalaCards organs/tissues related to Lyme Disease:

32
Heart, Testes, Skin, Eye, Brain, T cells, Endothelial, B cells, Retina, Spinal cord, Kidney, Liver, Salivary gland, Breast

Animal Models for Lyme Disease or affiliated genes

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MGI Mouse Phenotypes related to Lyme Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.9CD40LG, CFH, TLR2
2MP:00053877.7CD40LG, CIITA, CFH, TLR1, TLR2
3MP:00053977.4TLR2, TLR1, CFH, CIITA, CD40LG

Publications for Lyme Disease

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Articles related to Lyme Disease:

(show top 50)    (show all 650)
idTitleAuthorsYear
1
Integrated assessment of behavioral and environmental risk factors for lyme disease infection on block island, rhode island. (24416278)
2014
2
Provider Knowledge, Attitudes, and Practices Regarding Lyme Disease in Arkansas. (25187225)
2014
3
Post-infectious glomerulonephritis presenting as acute renal failure in a patient with Lyme disease. (25340158)
2014
4
Increased IFNI+ activity and differential antibody response in patients with a history of Lyme disease and persistent cognitive deficits. (23141748)
2013
5
Distribution of cp32 prophages among Lyme disease-causing spirochetes and natural diversity of their lipoprotein-encoding erp loci. (23624478)
2013
6
Potential role of deer tick virus in Powassan encephalitis cases in Lyme disease-endemic areas of New York, U.S.A. (24274334)
2013
7
Multi-criteria decision analysis as an innovative approach to managing zoonoses: results from a study on Lyme disease in Canada. (24079303)
2013
8
The Lyme disease debate: host biodiversity and human disease risk. (23548684)
2013
9
Experience of Lyme disease and preferences for precautions: a cross-sectional survey of UK patients. (23679931)
2013
10
Reductions in human Lyme disease risk due to the effects of oral vaccination on tick-to-mouse and mouse-to-tick transmission. (23428088)
2013
11
Bull's eye! Lyme disease awareness. (24137697)
2013
12
Does high biodiversity reduce the risk of Lyme disease invasion? (23816142)
2013
13
Lyme disease--unusual medical encounter for an urologist. (23700896)
2012
14
What do we need to know about disease ecology to prevent Lyme disease in the northeastern United States? (22308766)
2012
15
A single-domain FlgJ contributes to flagellar hook and filament formation in the Lyme disease spirochete Borrelia burgdorferi. (22155773)
2012
16
Lyme disease: knowledge, beliefs, and practices of physicians in a low-endemic area. (22734172)
2012
17
Neurogenic bladder in lyme disease. (23346488)
2012
18
Lyme disease. (22608120)
2012
19
Lyme disease presenting as ptosis, conjunctivitis, and photophobia. (21224251)
2012
20
Diagnosis and management of Lyme disease. (22962880)
2012
21
Probable late lyme disease: a variant manifestation of untreated Borrelia burgdorferi infection. (22853630)
2012
22
Advice for patients. Lyme disease in children and adolescents. (21199990)
2011
23
Canine serology as adjunct to human Lyme disease surveillance. (21888800)
2011
24
Lyme disease enolpyruvyl-UDP-GlcNAc synthase: fosfomycin-resistant MurA from Borrelia burgdorferi, a fosfomycin-sensitive mutant, and the catalytic role of the active site Asp. (21294548)
2011
25
Pervasive recombination and sympatric genome diversification driven by frequency-dependent selection in Borrelia burgdorferi, the Lyme disease bacterium. (21890743)
2011
26
The pain of chronic Lyme disease: moving the discourse backward? (22131364)
2011
27
Trial of a minimal-risk botanical compound to control the vector tick of Lyme disease. (20695287)
2010
28
Invasion of the lyme disease vector Ixodes scapularis: implications for Borrelia burgdorferi endemicity. (20229127)
2010
29
Recent discovery of widespread Ixodes affinis (Acari: Ixodidae) distribution in North Carolina with implications for Lyme disease studies. (20618664)
2010
30
The utility of "Google Trends" for epidemiological research: Lyme disease as an example. (20503183)
2010
31
The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete. (19906179)
2009
32
Hosts as ecological traps for the vector of Lyme disease. (19692412)
2009
33
Successful desensitisation to ceftriaxone in a patient with doxycicline resistant Lyme disease. (19445868)
2009
34
NerveCenter: Guideline-making gets tougher: action by state attorney general over Lyme disease guidelines stirs debate. (19334071)
2009
35
Complement split products c3a and c4a in chronic lyme disease. (19140878)
2009
36
Community-based prevention of Lyme disease and other tick-borne diseases through topical application of acaricide to white-tailed deer: background and rationale. (19650729)
2009
37
A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi. (19218460)
2009
38
Significantly improved accuracy of diagnosis of early Lyme disease by peptide enzyme-linked immunosorbent assay based on the borreliacidal antibody epitope of Borrelia burgdorferi OspC. (18417666)
2008
39
IgE anti-Borrelia burgdorferi components (p18, p31, p34, p41, p45, p60) and increased blood CD8+CD60+ T cells in children with Lyme disease. (17386029)
2007
40
Differential binding of host complement inhibitor factor H by Borrelia burgdorferi Erp surface proteins: a possible mechanism underlying the expansive host range of Lyme disease spirochetes. (11796574)
2002
41
Atypical erythema multiforme occurring at the early phase of Lyme disease? (10954224)
2000
42
Carbamazepine in the treatment of Lyme disease-induced hyperacusis. (9990563)
1999
43
Recurrent human granulocytic ehrlichiosis and Lyme disease. (10383360)
1999
44
Lyme disease and human granulocytic ehrlichiosis. (9322603)
1997
45
A monoclonal antibody to Borrelia burgdorferi flagellin modifies neuroblastoma cell neuritogenesis in vitro: a possible role for autoimmunity in the neuropathy of Lyme disease. (9125553)
1997
46
Uptake and killing of Lyme disease and relapsing fever borreliae in the perfused rat liver and by isolated Kupffer cells. (8613404)
1996
47
Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. (8551229)
1996
48
Establishment of enzyme-linked immunosorbent assay using purified recombinant 83-kilodalton antigen of Borrelia burgdorferi sensu stricto and Borrelia afzelii for serodiagnosis of Lyme disease. (8567889)
1995
49
Immune recognition of human Hsp60 by Lyme disease patient sera. (8100982)
1993
50
Iritis and papillitis as a primary presentation of Lyme disease. (2310116)
1990

Variations for Lyme Disease

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Expression for genes affiliated with Lyme Disease

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Expression patterns in normal tissues for genes affiliated with Lyme Disease

Search GEO for disease gene expression data for Lyme Disease.

Pathways for genes affiliated with Lyme Disease

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Pathways related to Lyme Disease according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TLR2, CD40LG
2
Show member pathways
9.4TLR2, TLR1
39.4TLR1, TLR2
4
Show member pathways
9.4TLR1, TLR2
59.4TLR1, TLR2
6
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.4TLR1, TLR2
7
Show member pathways
IL27-mediated signaling events37
9.4TLR1, TLR2
8
Show member pathways
9.4TLR1, TLR2
99.3HSPA8, TLR2
109.3CD40LG, CIITA
11
Show member pathways
9.0CD40LG, TLR1, TLR2
12
Show member pathways
8.8CD40LG, CIITA, HSPA8
138.6TLR2, TLR1, CIITA
14
Show member pathways
8.5TLR2, HSPA8, CIITA
15
Show member pathways
8.1CD40LG, CIITA, HSPA8, TLR2

Compounds for genes affiliated with Lyme Disease

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Compounds related to Lyme Disease according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1pneumococcal4410.0CD40LG, CFH
2silicone449.9CD40LG, HSPA8
3glucuronoxylomannan449.9TLR2, CD40LG
4cardiolipin44 1210.9CD40LG, CFH
5mannan449.8CD40LG, TLR2
6pam2csk4609.8TLR2, TLR1
7pam3csk4609.8TLR2, TLR1
8poly(i:c)609.8TLR2, TLR1
9resiquimod44 6010.8TLR1, TLR2
10flagellin44 2910.8TLR2, TLR1
11imiquimod44 60 29 1212.8TLR2, TLR1
12lipoteichoic acid449.7TLR1, TLR2
13anti-fungal449.7CD40LG, TLR2
14theophylline44 29 25 1212.7CD40LG, HSPA8
15mannitol44 1210.5CD40LG, HSPA8
16dextran sulfate449.5CD40LG, CIITA
17enterotoxin449.4TLR2, CIITA
18ganglioside449.3CD40LG, CIITA
19deoxyribonucleic acid449.3CIITA, HSPA8
20polyinosinic-polycytidylic acid449.3CIITA, TLR2
21polysaccharide449.3CD40LG, CFH, TLR2
22fibrinogen449.3CD40LG, CFH, TLR2
23cisplatin44 50 60 1212.2CFH, HSPA8, CD40LG
24allergens449.2CD40LG, CIITA, HSPA8
25heparin44 29 25 1212.1CFH, CFHR1, HSPA8, CD40LG
26dopamine44 29 25 1212.0HSPA8, CIITA, CD40LG
27actinomycin d449.0TLR2, CIITA, CD40LG
28simvastatin44 50 60 29 25 1213.9TLR2, HSPA8, CIITA
29ribonucleic acid448.9CIITA, HSPA8, TLR2
30hydrogen44 259.8CIITA, HSPA8, TLR2
31vegf448.7TLR2, HSPA8, CD40LG
32zinc44 259.6CIITA, HSPA8, CFH
33endotoxin448.6CD40LG, CIITA, HSPA8, TLR2
34rantes448.6TLR2, HSPA8, CIITA, CD40LG
35pge2448.6TLR2, HSPA8, CIITA, CD40LG
36dexamethasone44 50 29 1211.5CD40LG, CIITA, CFH, TLR2
37peptidoglycan44 299.5CIITA, HSPA8, TLR1, TLR2
38cholesterol44 29 25 1211.4TLR2, CFH, HSPA8, CIITA
39glucose448.3TLR2, CFH, HSPA8, CIITA
40lipid448.3TLR2, TLR1, HSPA8, CIITA
41cyclosporin a44 29 6010.1TLR2, CFH, HSPA8, CIITA, CD40LG
42alanine448.0CD40LG, CIITA, HSPA8, CFH, TLR2
43cysteine448.0TLR2, CFH, HSPA8, CIITA, CD40LG
44serine448.0CD40LG, CIITA, HSPA8, CFH, TLR2
45tyrosine448.0TLR2, CFH, HSPA8, CIITA

GO Terms for genes affiliated with Lyme Disease

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Cellular components related to Lyme Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:0353549.1TLR1, TLR2
2blood microparticleGO:0725629.0HSPA8, CFHR1, CFH

Biological processes related to Lyme Disease according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cellular response to triacyl bacterial lipopeptideGO:0717279.6TLR1, TLR2
2detection of triacyl bacterial lipopeptideGO:0424959.5TLR1, TLR2
3positive regulation of interleukin-12 productionGO:0327359.5TLR2, CD40LG
4positive regulation of tumor necrosis factor biosynthetic processGO:0425359.5TLR1, TLR2
5complement activationGO:0069569.4CFH, CFHR1
6toll-like receptor signaling pathwayGO:0022249.4TLR1, TLR2
7innate immune responseGO:0450878.6CFH, TLR1, TLR2
8immune responseGO:0069558.6CIITA, TLR1, TLR2
9inflammatory responseGO:0069548.4TLR2, TLR1, CIITA, CD40LG

Molecular functions related to Lyme Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.4TLR1, TLR2

Products for genes affiliated with Lyme Disease

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  • Antibodies
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  • Lysates
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  • Kits and Assays

Sources for Lyme Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet