Aliases & Classifications for Lymph Node Disease

MalaCards integrated aliases for Lymph Node Disease:

Name: Lymph Node Disease 12 14
Disorder of Lymph Node 69


External Ids:

Disease Ontology 12 DOID:9942
NCIt 47 C35346
SNOMED-CT 64 76616003
UMLS 69 C0272394

Summaries for Lymph Node Disease

MalaCards based summary : Lymph Node Disease, also known as disorder of lymph node, is related to supranuclear ocular palsy and kleptomania, and has symptoms including axillary lymph node pain, inguinal lymph node pain and inguinal lymph node tenderness. An important gene associated with Lymph Node Disease is MMP3 (Matrix Metallopeptidase 3), and among its related pathways/superpathways are T cell receptor signaling pathway and IL-17 Family Signaling Pathways. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, breast and prostate, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Wikipedia : 72 A lymph node or lymph gland is an ovoid or kidney-shaped organ of the lymphatic system, and of the... more...

Related Diseases for Lymph Node Disease

Diseases related to Lymph Node Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 283)
id Related Disease Score Top Affiliating Genes
1 supranuclear ocular palsy 11.0 MMP1 MMP3
2 kleptomania 10.8 MMP1 MMP3
3 persistent generalized lymphadenopathy 10.8
4 carcinoid tumors, intestinal 10.7 SDHB SDHC SDHD
5 paraganglioma and gastric stromal sarcoma 10.7 SDHB SDHC SDHD
6 serous surface papilloma 10.7 SDHB SDHC SDHD
7 primary oculocerebral lymphoma 10.6 SDHB SDHC SDHD
8 brown's tendon sheath syndrome 10.6 CD40LG SDHD
9 erythrocytosis, familial, 2 10.5 SDHB SDHC SDHD
10 hypolipoproteinemia 10.5 CD40LG CRP MMP3
11 viral encephalitis 10.5 SDHB SDHC SDHD
12 benign shuddering attacks 10.5 SDHB SDHC SDHD
13 balkan hemorrhagic fever 10.5 CD40LG IL10
14 lung disease 10.4 CD40LG MMP3 TNF
15 pure autonomic failure 10.4 IL10 TNF
16 intra-abdominal lymph node mast cell malignancy 10.4 CRP MMP1 TNF
17 acute ackee fruit intoxication 10.4 IL10 TNF
18 collagenopathy type 2 alpha 1 10.4 CRP IL6
19 rete ovarii cystadenoma 10.3 SDHAF2 SDHB SDHC SDHD
20 uterine corpus endometrial carcinoma 10.3 SDHAF2 SDHB SDHC SDHD
21 nervous system cancer 10.3 IL6 MMP1 MMP3
22 acquired polycythemia 10.3 CD40LG CRP
23 mercaptolactate-cysteine disulfiduria 10.3 SDHA SDHB SDHC SDHD
24 smarca4-deficient sarcoma of thorax 10.3 IL6 TNF
25 functional gastric disease 10.3 CD40LG CRP TNF
26 leprosy 4 10.3 CRP MMP1 MMP3 TNF
27 benign mammary dysplasia 10.2 CD40LG CRP TNF
28 gastrointestinal stromal tumor 10.2 SDHA SDHB SDHC SDHD
29 crystal arthropathies 10.2 CRP IL6
30 alcoholic neuropathy 10.2 CD40LG CD79A
31 calloso-genital dysplasia 10.2 CD40LG CD79A
32 aortic arch interruption 10.2 IL6 TNF
33 multiple familial trichoepithelioma 10.2 IL10 TNF
34 variola major 10.2 CD40LG CD79A
35 mu chain disease 10.2 CD40LG CD79A
36 rabies 10.2 CD40LG CD79A
37 familial retinoblastoma 10.2 CD40LG CD79A
38 anti-basement membrane glomerulonephritis 10.2 CD40LG CD79A
39 microinvasive cervical squamous cell carcinoma 10.1 CD40LG CD79A
40 fetal erythroblastosis 10.1 CD40LG CD79A
41 keloids 10.1 IL6 MMP3 TNF
42 spinal canal and spinal cord meningioma 10.1 CD40LG CD79A
43 acquired thrombocytopenia 10.1 IL6 MMP1 TNF
44 trichostrongyloidiasis 10.1 CD40LG CD79A
45 basidiobolomycosis 10.1 IL10 TNF
46 rheumatic myocarditis 10.1 IL6 MMP1 TNF
47 leukodystrophy 10.1 CD40LG CD79A
48 retinal microaneurysm 10.1 CD40LG CD79A
49 heart septal defect 10.1 CD40LG CD79A
50 cutaneous leishmaniasis 10.1 IL6 TNF

Graphical network of the top 20 diseases related to Lymph Node Disease:

Diseases related to Lymph Node Disease

Symptoms & Phenotypes for Lymph Node Disease

UMLS symptoms related to Lymph Node Disease:

axillary lymph node pain, inguinal lymph node pain, inguinal lymph node tenderness

MGI Mouse Phenotypes related to Lymph Node Disease:

id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 IL10 IL6 MMP1 MMP14 MMP3 SDHA
2 endocrine/exocrine gland MP:0005379 10.02 IL6 ITPKC MMP14 SDHB SDHD TNF
3 hematopoietic system MP:0005397 10.02 CD40LG CD79A EPCAM IL10 IL6 ITGAE
4 immune system MP:0005387 9.93 CD40LG CD79A CRP EPCAM IL10 IL6
5 neoplasm MP:0002006 9.5 CD79A IL10 IL6 MMP1 SDHB SDHD
6 no phenotypic analysis MP:0003012 9.17 CD79A EPCAM IL10 MMP14 SDHB TMEM127

Drugs & Therapeutics for Lymph Node Disease

Drugs for Lymph Node Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 515)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 1 53-03-2 5865
Menthol Approved Phase 4,Phase 3,Phase 2 2216-51-5 16666
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
Epirubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 56420-45-2 41867
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33069-62-4 36314
Vinorelbine Approved, Investigational Phase 4,Phase 3,Phase 2 71486-22-1 60780 44424639
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
Vancomycin Approved Phase 4 1404-90-6 441141 14969
Somatostatin Approved Phase 4 38916-34-6, 51110-01-1 53481605
Irinotecan Approved, Investigational Phase 4,Phase 2 97682-44-5, 100286-90-6 60838
Levoleucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1 68538-85-2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
Edetic Acid Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 60-00-4, 62-33-9 6049
Vinblastine Approved Phase 4,Phase 3,Phase 2 865-21-4 13342 241903
Ganciclovir Approved, Investigational Phase 4,Phase 2 82410-32-0 3454
Valganciclovir Approved, Investigational Phase 4,Phase 2 175865-60-8 64147
Ledipasvir Approved Phase 4 1256388-51-8 67505836
Ribavirin Approved Phase 4 36791-04-5 37542
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 59-30-3 6037
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 143 6006
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
Methylene blue Investigational Phase 4,Phase 3,Phase 2 61-73-4
Docetaxel Approved May 1996, Investigational Phase 4,Phase 3,Phase 2,Phase 1 114977-28-5 148124 9877265
Camptothecin Experimental Phase 4,Phase 2 7689-03-4
31 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
33 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
34 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
35 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
37 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
38 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
39 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
40 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
41 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
42 Antipyretics Phase 4,Phase 3,Phase 2
43 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
45 Fibrinolytic Agents Phase 4,Phase 2,Phase 3,Phase 1
46 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
47 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Platelet Aggregation Inhibitors Phase 4,Phase 2
49 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1321)

id Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Unknown status NCT00313066 Phase 4
3 Endoesophageal Cryotherapy For Ablating Barrett's Esophagus and Early Stage Esophageal Cancer Unknown status NCT00628784 Phase 4
4 MR-Lymphography and Lymph Node Staging in Prostate Cancer Unknown status NCT00185029 Phase 4
5 Study of Combined Therapy of Aspirin and "IVIG-SN" in Kawasaki Disease Completed NCT01524939 Phase 4 immunoglobulin G
6 Conventional Versus Ultrasound-guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymphadenopathies Completed NCT01658280 Phase 4
7 RCT: Difference in Diagnostic Yield Between EUSFNA Needles With and Without a Side Port in Pancreatic Masses Completed NCT02092519 Phase 4
8 Clinical and Economic Outcomes of Ceftaroline Fosamil for ABSSSI Documented or at Risk of MRSA Completed NCT02582203 Phase 4 Ceftaroline;Vancomycin
9 Post-Operative Drainage Following Lymph Node Dissection Completed NCT00324272 Phase 4 Fibrin Sealant (Tisseel) used in the Experimental Arm.
10 Sentinel Lymph Node Mapping Post-Injection Site Pain Completed NCT02065232 Phase 4 Tilmanocept;Sulfur Colloid
11 A Study for Lymphocele and Lymphorrhea Control Following Inguinal and Axillary Radical Lymph Node Dissection Completed NCT02476357 Phase 4
12 Application of Somatostatin for Advanced Gastric Cancer After D2 Lymph Node Dissection Completed NCT01914692 Phase 4 Somatostatin
13 Effect of TachoSil® on Incidence of Symptomatic and Radiographic Lymphoceles After Extended Pelvic Lymph Node Dissection in Prostate and Bladder Cancer. Completed NCT02001857 Phase 4 1 TachoSil hemostatic sponge (9,5 cm x 4,8 cm) placed on each side on the external iliac artery.
14 Study the Use of Magseed and Sentimag to Localize Axillary Lymph Nodes Recruiting NCT03038152 Phase 4
15 A Multi-center, Randomized to Compare the Efficacy of IVIG Alone and IVIG Plus High-dose Aspirin in Kawasaki Disease Recruiting NCT02951234 Phase 4
16 Laparoscopic Versus Open Resection of Cancer Stomach Recruiting NCT02789826 Phase 4
17 Genetic Analysis-Guided Irinotecan Hydrochloride Dosing of mFOLFIRINOX in Treating Patients With Locally Advanced Gastroesophageal or Stomach Cancer Recruiting NCT02366819 Phase 4 Oxaliplatin;Leucovorin Calcium;Irinotecan Hydrochloride;Fluorouracil
18 Surgery Alone, Surgery With Cyclophosphamide, Vinblastine, and Prednisolone (CVP), or CVP Alone in Treating Young Patients With Stage IA or Stage IIA Nodular Lymphocyte-Predominant Hodgkin Lymphoma Recruiting NCT01088750 Phase 4 cyclophosphamide;prednisolone;vinblastine sulfate
19 The Optimal Neck Treatments Strategy of Early Oral Cancer Based on Adverse Pathological Factor Recruiting NCT03017053 Phase 4
20 Selective Lymph Node Dissection Using Fluorescent Dye in Node-positive Breast Cancer Recruiting NCT02781259 Phase 4 Indocyanine green
21 Methylene Blue Intradermal Injection for Sentinel Lymph Node Biopsy for Breast Cancer Patients Recruiting NCT02982148 Phase 4
22 Tilmanocept vs Sulfur Colloid in Sentinel Lymph Node Biopsy Recruiting NCT03199560 Phase 4 Tc 99m tilmanocept;Tc 99m filtered sulfur colloid
23 Epirubicin Versus Docetaxel Plus Cyclophosphamide in Lymph Node Negative, ER-positive, Her2-negative Breast Cancer Recruiting NCT02549677 Phase 4 Epirubicin;Docetaxel;cyclophosphamide
24 Oral Hepatitis C Treatment for Indolent Lymphoma (OPTImaL) Study Active, not recruiting NCT02717949 Phase 4 sofosbuvir/ledipasvir;sofosbuvir;Ribavirin
25 Sentinel Lymph Node Biopsy Findings in Patients With Breast Cancer Active, not recruiting NCT02287675 Phase 4 Lymphoseek;Sulfur Colloid
26 Research of Intensive Treatment in Hormone Receptor<10% and Human Epidermal Growth Factor Receptor-2 Negative Breast Cancer Patients With Positive Lymph Node Residual Disease After Neoadjuvant Chemotherapy Not yet recruiting NCT03270007 Phase 4 Vinorelbine
27 Sienna+® Injection Time Study 4 Arms Not yet recruiting NCT02612870 Phase 4
28 GeneSearch Breast Lymph Node (BLN) Assay Timing Study Terminated NCT00595023 Phase 4
29 Valganciclovir to Treat HHV-8 Associated Multicentric Castleman's Disease Withdrawn NCT00361933 Phase 4 Valganciclovir
30 Magnetic Resonance Imaging for Lymph Node Staging in Ovarian Cancer Withdrawn NCT02243059 Phase 4 Gadofosveset trisodium (Ablavar™ )
31 Study of Exemestane After Anastrozole or Letrozole Treatment of Postmenopausal Women With Hormone Responsive Breast Cancer Unknown status NCT00902954 Phase 3 anastrozole;letrozole;exemestane
32 Usefulness of FDG-PET for Advanced Cervical Cancer Unknown status NCT00146458 Phase 3
33 Docetaxel Based Anthracycline Free Adjuvant Treatment Evaluation, as Well as Life Style Intervention Unknown status NCT00847444 Phase 3 Drug-based intervention
34 PET/CT Scan-Guided Watchful Waiting or Neck Dissection of Locally Advanced Lymph Node Metastases in Treating Patients Undergoing Chemotherapy and Radiation Therapy for Primary Head And Neck Cancer Unknown status NCT00720070 Phase 3
35 Nimotuzumab in Combination With Chemoradiation for Nasopharyngeal Cancer Unknown status NCT01074021 Phase 3 Nimotuzumab;placebo plus chemoradiotherapy
36 A Study Comparing Adjuvant Chemotherapy Versus Observation for Patients With Rectal Adenocarcinoma After Neoadjuvant Chemo-Radiotherapy Treatment. Unknown status NCT01941979 Phase 3 5-FU, Capecitabine, Oxaliplatin, Leucovorin.
37 Digital Mammography, Ultrasound, MRI, and PET Scans in Women With Newly Diagnosed Breast Cancer Unknown status NCT00194337 Phase 2, Phase 3
38 A Multicenter Clinical Trial on Laparoscopic Gastric Cancer Surgery Compared With Open Surgery Unknown status NCT02302794 Phase 3
39 Study of Micrometastases in Patients With Stage I or Stage II Localized Colon Cancer That Can Be Removed by Surgery Unknown status NCT01097265 Phase 2, Phase 3 capecitabine;oxaliplatin
40 Three Field Radical Esophagectomy Versus Two Field Esophagectomy - a Prospective Trial Unknown status NCT00193817 Phase 3
41 Epirubicin and Tamoxifen With or Without Docetaxel in Treating Postmenopausal Women With Breast Cancer Unknown status NCT00010140 Phase 3 docetaxel;epirubicin hydrochloride;tamoxifen citrate
42 Sentinel Lymph Node Biopsy With Superparamagnetic Iron Oxide for Breast Cancer Patients After Neoadjuvant Treatment. Unknown status NCT02249208 Phase 3
43 Computed Tomography (CT) Based Lymphatic Mapping and Localization of Sentinel Lymph Node in Breast Cancer Patients Unknown status NCT00952679 Phase 3
44 Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Nonmetastatic Breast Cancer Unknown status NCT01093235 Phase 3 cyclophosphamide;docetaxel;epirubicin hydrochloride;fluorouracil
45 Premenopausal Patient With Hormone Responsive, HER2 Negative, Lymph Node Positive Breast Cancer Unknown status NCT01622361 Phase 3 Adriamycin+Cyclophosphamide>Docetaxel;GnRHa with Tamoxifen
46 Lymph Node Radiation Therapy in Patients With Stage I, Stage II, or Stage III Breast Cancer That Has Been Surgically Removed Unknown status NCT00002851 Phase 3
47 Clinical Study on the Harvesting Lymph Nodes With Carbon Nanoparticles for Advanced Gastric Cancer Unknown status NCT02123407 Phase 3 Carbon Nanoparticles
48 Chemoradiation With or Without Nimotuzumab in Treating Esophageal Cancer Patients Who Suffer With Recurrence in Regional Lymph Nodes After Esophagectomy Unknown status NCT01402180 Phase 2, Phase 3 chemotherapy;chemotherapy
49 Immediate Radiotherapy or Observation After Surgery for Melanoma Involving Lymph Nodes Completed NCT00287196 Phase 3
50 Study of Docetaxel in Breast Cancer Patients Completed NCT00174707 Phase 3 epidoxorubicine, ciclophosphamide, methotrexate, fluorouracile;epidoxorubicine, docetaxel, ciclophosphamide, methotrexate, fluorouracile;epidoxorubicine, docetaxel, cyclophosphamide

Search NIH Clinical Center for Lymph Node Disease

Genetic Tests for Lymph Node Disease

Anatomical Context for Lymph Node Disease

MalaCards organs/tissues related to Lymph Node Disease:

Lymph Node, Breast, Prostate, Lung, Thyroid, Colon, T Cells

Publications for Lymph Node Disease

Articles related to Lymph Node Disease:

(show all 24)
id Title Authors Year
Management of Para-aortic Lymph Node Disease in Patients With Cervical Cancer: What Is the Best Approach? ( 28107261 )
Letter to the Editor on "Management of Para-aortic Lymph Node Disease in Patients With Cervical Cancer": What is the Best Approach? Int J Gynecol Cancer. 2017 Mar; 27(3): 543549. ( 28708789 )
Axillary Ultrasound Accurately Excludes Clinically Significant Lymph Node Disease in Patients With Early Stage Breast Cancer. ( 26779976 )
Unexpected lymph node disease in resections for pulmonary metastases. ( 25440271 )
Is Minimal Residual Lymph Node Disease in Papillary Thyroid Cancer of Prognostic Impact? An Analysis of The Epithelial Cell Adhesion Molecule EpCAM in Lymph Nodes of 40 pN0 Patients. ( 23918549 )
Critical analysis of the 2010 TNM classification in patients with lymph node-positive bladder cancer: influence of lymph node disease burden. ( 25027685 )
Clinical feasibility and diagnostic accuracy of detecting micrometastatic lymph node disease in sentinel and non-sentinel lyph nodes in cervical cancer: outcomes and implications. ( 24505957 )
The prognosis of N2b and N2c lymph node disease in oral squamous cell carcinoma is determined by the number of metastatic lymph nodes rather than laterality: evidence to support a revision of the American Joint Committee on Cancer staging system. ( 24691658 )
Imaging response and residual metastatic axillary lymph node disease after neoadjuvant chemotherapy for primary breast cancer. ( 23846781 )
Subcutaneous emphysema as the first relevant clinical sign of complicated tubercular lymph node disease in a child. ( 24094042 )
Survival of patients with non-small cell lung cancer according to lymph node disease: single pN1 vs multiple pN1 vs single unsuspected pN2. ( 23378017 )
Residual lymph node disease after neoadjuvant chemotherapy predicts an increased risk of lymphedema in node-positive breast cancer patients. ( 23689935 )
The impact of lymph node disease in extremity soft-tissue sarcomas: a population-based analysis. ( 23806824 )
Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer. ( 22120175 )
Is Warthin's tumour of the parotid gland a lymph node disease? ( 21771031 )
Prognostic significance and tumor biology of regional lymph node disease in patients with rhabdomyosarcoma: a report from the Children's Oncology Group. ( 21357792 )
Micrometastatic sentinel lymph node disease: do patients benefit or suffer harm from axillary lymph node dissection? ( 19937389 )
Minimal disease in the sentinel lymph node: how to best measure sentinel node micrometastases to predict risk of additional non-sentinel lymph node disease. ( 20532987 )
Epithelial ovarian cancer relapsing as isolated lymph node disease: natural history and clinical outcome. ( 19077269 )
Lymph node disease after radical prostatectomy. ( 17431370 )
Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature. ( 17916603 )
Prospective comparative study of integrated positron emission tomography-computed tomography scan compared with remediastinoscopy in the assessment of residual mediastinal lymph node disease after induction chemotherapy for mediastinoscopy-proven stage IIIA-N2 Non-small-cell lung cancer: a Leuven Lung Cancer Group Study. ( 16849747 )
High-risk cutaneous squamous cell carcinoma of the head and neck: results from 266 treated patients with metastatic lymph node disease. ( 16649220 )
Metaanalysis of the significance of matrix metalloproteinases for lymph node disease in patients with head and neck squamous cell carcinoma. ( 15912516 )

Variations for Lymph Node Disease

Expression for Lymph Node Disease

Search GEO for disease gene expression data for Lymph Node Disease.

Pathways for Lymph Node Disease

Pathways related to Lymph Node Disease according to GeneCards Suite gene sharing:

(show all 24)
id Super pathways Score Top Affiliating Genes
Show member pathways
12.33 CD40LG IL10 IL6 TNF
Show member pathways
12.23 IL6 MMP1 MMP3 TNF
Show member pathways
4 12.09 IL6 MMP1 MMP14 TNF
Show member pathways
6 11.88 CD79A IL10 IL6 TNF
7 11.81 IL6 MMP14 MMP3 TNF
Show member pathways
Show member pathways
11.73 MMP1 MMP14 MMP3 TNF
10 11.71 IL10 IL6 MMP1 MMP3 TNF
11 11.69 IL10 ITGAE TNF
12 11.66 IL10 IL6 TNF
13 11.66 IL6 MMP1 MMP3 TNF
14 11.55 MMP1 MMP14 MMP3
16 11.42 IL10 IL6 TNF
17 11.31 CD40LG IL10 IL6 TNF
18 11.26 IL10 IL6 TNF
19 11.24 IL10 IL6 TNF
20 11.2 CD40LG IL10 IL6 ITGAE TNF
21 11.15 IL10 IL6 TNF
22 11.11 CD40LG IL10 IL6 TNF
23 10.82 CRP IL6 TNF
Show member pathways
10.82 CD40LG IL6 MMP1 MMP3 TNF

GO Terms for Lymph Node Disease

Cellular components related to Lymph Node Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.55 CD40LG CD79A IL6 ITGAE TNF
2 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHA SDHB SDHC SDHD

Biological processes related to Lymph Node Disease according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.85 CD40LG CRP IL10 IL6 TNF
2 extracellular matrix disassembly GO:0022617 9.72 MMP1 MMP14 MMP3
3 response to glucocorticoid GO:0051384 9.7 IL10 IL6 TNF
4 B cell differentiation GO:0030183 9.69 CD40LG CD79A IL10
5 collagen catabolic process GO:0030574 9.67 MMP1 MMP14 MMP3
6 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL10 TNF
7 succinate metabolic process GO:0006105 9.54 SDHA SDHB
8 B cell proliferation GO:0042100 9.5 CD40LG CD79A IL10
9 endothelial cell apoptotic process GO:0072577 9.48 IL10 TNF
10 negative regulation of cytokine secretion involved in immune response GO:0002740 9.43 IL10 TNF
11 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.4 IL6 TNF
12 regulation of immunoglobulin secretion GO:0051023 9.37 CD40LG TNF
13 tricarboxylic acid cycle GO:0006099 9.35 SDHA SDHAF2 SDHB SDHC SDHD
14 negative regulation of lipid storage GO:0010888 9.33 CRP IL6 TNF
15 receptor biosynthetic process GO:0032800 9.26 IL10 TNF
16 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.8 SDHA SDHAF2 SDHD

Molecular functions related to Lymph Node Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.62 CD40LG IL10 IL6 TNF
2 electron carrier activity GO:0009055 9.46 SDHA SDHB SDHC SDHD
3 ubiquinone binding GO:0048039 9.26 SDHB SDHD
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.13 SDHA SDHB SDHD
5 succinate dehydrogenase activity GO:0000104 8.8 SDHA SDHC SDHD

Sources for Lymph Node Disease

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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