Aliases & Classifications for Lymph Node Disease

MalaCards integrated aliases for Lymph Node Disease:

Name: Lymph Node Disease 12 14
Disorder of Lymph Node 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9942
NCIt 46 C35346
SNOMED-CT 64 76616003
UMLS 69 C0272394

Summaries for Lymph Node Disease

MalaCards based summary : Lymph Node Disease, also known as disorder of lymph node, is related to persistent generalized lymphadenopathy and superior limbic keratoconjunctivitis, and has symptoms including inguinal lymph node tenderness, inguinal lymph node pain and axillary lymph node pain. An important gene associated with Lymph Node Disease is MMP3 (Matrix Metallopeptidase 3), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Carbon metabolism. The drugs Cisplatin and Progesterone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, breast and thyroid, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Lymph Node Disease

Diseases related to Lymph Node Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 230)
# Related Disease Score Top Affiliating Genes
1 persistent generalized lymphadenopathy 29.8 CD40LG CD79A SDHA SDHAF2 SDHB SDHC
2 superior limbic keratoconjunctivitis 10.7 MMP1 MMP3
3 spastic entropion 10.6 MMP1 MMP3
4 paragangliomas 1 10.4 SDHB SDHC SDHD
5 paraganglioma and gastric stromal sarcoma 10.4 SDHB SDHC SDHD
6 chondroma 10.4 SDHB SDHC SDHD
7 sporadic pheochromocytoma 10.4 SDHB SDHC SDHD
8 borderline leprosy 10.4 CD40LG SDHD
9 von hippel-lindau syndrome 10.4 SDHB SDHC SDHD
10 cowden disease 10.3 SDHB SDHC SDHD
11 endocrine gland cancer 10.3 SDHB SDHC SDHD
12 multiple cranial nerve palsy 10.3 CD40LG CRP MMP3
13 selective igg deficiency disease 10.3 CD40LG CD79A
14 c1q nephropathy 10.3 CD40LG CD79A
15 acalculous cholecystitis 10.3 CD40LG CRP
16 neurofibromatosis, type iv, of riccardi 10.3 SDHB SDHC SDHD
17 meningovascular neurosyphilis 10.3 CD40LG CD79A
18 alpha chain disease 10.3 CD40LG CD79A
19 brill-zinsser disease 10.3 CD40LG CD79A
20 exudative glomerulonephritis 10.3 CD40LG CD79A
21 cork-handlers' disease 10.3 CD40LG CD79A
22 salpingo-oophoritis 10.3 CD40LG CD79A
23 kashin-beck disease 10.3 MMP1 TNF
24 early yaws 10.3 CD40LG CD79A
25 ventilation pneumonitis 10.3 CD40LG CD79A
26 chronic interstitial cystitis 10.3 CD40LG CD79A
27 axillary adenitis 10.3 CD40LG CD79A
28 cryofibrinogenemia 10.3 CD40LG CD79A
29 rheumatoid lung disease 10.2 CD40LG MMP3 TNF
30 trichostrongyloidiasis 10.2 CD40LG CD79A
31 subacute bacterial endocarditis 10.2 CD40LG CD79A
32 heterophyiasis 10.2 CD40LG CD79A
33 immunoglobulin g deficiency 10.2 CD40LG CD79A
34 carotid stenosis 10.2 CRP MMP1 TNF
35 sarcoidosis 1 10.2
36 squamous cell carcinoma of the hypopharynx 10.2 MMP1 MMP3
37 orbital granuloma 10.2 CD40LG CD79A
38 transient hypogammaglobulinemia of infancy 10.2 CD40LG CD79A
39 intestinal tuberculosis 10.2 CD79A CRP
40 fibrosarcoma 10.2 MMP1 MMP14 MMP3 TNF
41 adrenal medulla cancer 10.2 SDHAF2 SDHB SDHC SDHD
42 hyperglobulinemic purpura 10.2 CD40LG CD79A
43 extra-adrenal pheochromocytoma 10.2 SDHAF2 SDHB SDHC SDHD
44 gastroduodenitis 10.2 CD40LG CD79A
45 bacterial conjunctivitis 10.2 CD40LG CD79A
46 heavy chain disease 10.2 CD40LG CD79A
47 mononeuritis multiplex 10.2 CD40LG CRP
48 ophthalmia neonatorum 10.1 CD40LG CD79A
49 streptococcal meningitis 10.1 CD40LG CRP TNF
50 carney triad 10.1 SDHA SDHB SDHC SDHD

Graphical network of the top 20 diseases related to Lymph Node Disease:



Diseases related to Lymph Node Disease

Symptoms & Phenotypes for Lymph Node Disease

UMLS symptoms related to Lymph Node Disease:


inguinal lymph node tenderness, inguinal lymph node pain, axillary lymph node pain

MGI Mouse Phenotypes related to Lymph Node Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 IL6 ITGAE ITPKC MMP14 MMP3 SDHB
2 homeostasis/metabolism MP:0005376 9.8 IL6 MMP1 MMP14 MMP3 SDHA SDHB
3 immune system MP:0005387 9.4 IL6 ITGAE ITPKC MMP1 MMP14 MMP3

Drugs & Therapeutics for Lymph Node Disease

Drugs for Lymph Node Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
2
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
3
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
4
Docetaxel Approved May 1996, Investigational Phase 3 114977-28-5 148124 9877265
5 Estrogens Phase 3
6 Antimetabolites Phase 3
7 Antimetabolites, Antineoplastic Phase 3
8 Antimitotic Agents Phase 3
9
Inosine pranobex Approved 36703-88-5
10 Adjuvants, Immunologic
11 Anti-Infective Agents
12 Antiviral Agents
13 interferons
14 Interferon-alpha

Interventional clinical trials:

(show all 16)

# Name Status NCT ID Phase Drugs
1 Immediate Radiotherapy or Observation After Surgery for Melanoma Involving Lymph Nodes Completed NCT00287196 Phase 3
2 Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy Recruiting NCT01901094 Phase 3
3 Definitive Chemo-Radiotherapy for Regionally Advanced Head and Neck Cancer With or Without Up-front Neck Dissection Recruiting NCT02918955 Phase 3 Chemotherapy (Cisplatin)
4 Genetic Testing or Clinical Assessment in Determining the Need for Chemotherapy in Women With Breast Cancer That Involves No More Than 3 Lymph Nodes Active, not recruiting NCT00433589 Phase 3 anthracycline-based;docetaxel and capecitabine
5 Fluorescence Targeted Pelvic Lymph Node Mapping Enrolling by invitation NCT03204994 Phase 1, Phase 2 Indocyanine Green
6 Bronchoscopic Sampling Techniques in Sarcoidosis Unknown status NCT01836822
7 A Study of Isoprinosine in Patients With Lymph Node Disease Completed NCT00002297 Inosine pranobex
8 The Safety and Effectiveness of Isoprinosine in Patients With Weakened Immune Systems and Lymph Node Disease Completed NCT00002296 Inosine pranobex
9 CT Detection of Metastatic Lymphadenopathy in Papillary Thyroid Cancer Completed NCT03359668
10 LYMPHA: Eliminating the Burden of Lymphedema in Patients Requiring Nodal Dissection Recruiting NCT03073096
11 Radiotherapy of Pelvic Lymph Nodes in High Risk Prostate Cancer - A Retrospective Analysis Recruiting NCT02998619
12 MR-guided RAdiotherapy to Breast With Dose Escalation to regionaL Lymph NodEs Recruiting NCT03405519
13 Unlock the Cell: Castleman's Disease Flow Cytometry Study Recruiting NCT02853968
14 Recombinant Interferon Alfa-2b in Treating Patients With Melanoma Active, not recruiting NCT01460875
15 Evolution of Indications for Transbronchial Ganglionic Ultrasound in the Picardie Region Over the Period 2008 - 2013 Not yet recruiting NCT03132883
16 Dynamic Contrast Enhanced Computed Tomography (CT) for Head and Neck Cancer Terminated NCT01549379

Search NIH Clinical Center for Lymph Node Disease

Genetic Tests for Lymph Node Disease

Anatomical Context for Lymph Node Disease

MalaCards organs/tissues related to Lymph Node Disease:

38
Lymph Node, Breast, Thyroid, Testes, Prostate, Lung

Publications for Lymph Node Disease

Articles related to Lymph Node Disease:

(show all 24)
# Title Authors Year
1
Letter to the Editor on "Management of Para-aortic Lymph Node Disease in Patients With Cervical Cancer": What is the Best Approach? Int J Gynecol Cancer. 2017 Mar; 27(3): 543549. ( 28708789 )
2017
2
Management of Para-aortic Lymph Node Disease in Patients With Cervical Cancer: What Is the Best Approach? ( 28107261 )
2017
3
Axillary Ultrasound Accurately Excludes Clinically Significant Lymph Node Disease in Patients With Early Stage Breast Cancer. ( 26779976 )
2016
4
Unexpected lymph node disease in resections for pulmonary metastases. ( 25440271 )
2015
5
Is Minimal Residual Lymph Node Disease in Papillary Thyroid Cancer of Prognostic Impact? An Analysis of The Epithelial Cell Adhesion Molecule EpCAM in Lymph Nodes of 40 pN0 Patients. ( 23918549 )
2014
6
Critical analysis of the 2010 TNM classification in patients with lymph node-positive bladder cancer: influence of lymph node disease burden. ( 25027685 )
2014
7
The prognosis of N2b and N2c lymph node disease in oral squamous cell carcinoma is determined by the number of metastatic lymph nodes rather than laterality: evidence to support a revision of the American Joint Committee on Cancer staging system. ( 24691658 )
2014
8
Clinical feasibility and diagnostic accuracy of detecting micrometastatic lymph node disease in sentinel and non-sentinel lyph nodes in cervical cancer: outcomes and implications. ( 24505957 )
2014
9
Residual lymph node disease after neoadjuvant chemotherapy predicts an increased risk of lymphedema in node-positive breast cancer patients. ( 23689935 )
2013
10
Subcutaneous emphysema as the first relevant clinical sign of complicated tubercular lymph node disease in a child. ( 24094042 )
2013
11
Survival of patients with non-small cell lung cancer according to lymph node disease: single pN1 vs multiple pN1 vs single unsuspected pN2. ( 23378017 )
2013
12
Imaging response and residual metastatic axillary lymph node disease after neoadjuvant chemotherapy for primary breast cancer. ( 23846781 )
2013
13
The impact of lymph node disease in extremity soft-tissue sarcomas: a population-based analysis. ( 23806824 )
2013
14
Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer. ( 22120175 )
2012
15
Is Warthin's tumour of the parotid gland a lymph node disease? ( 21771031 )
2011
16
Prognostic significance and tumor biology of regional lymph node disease in patients with rhabdomyosarcoma: a report from the Children's Oncology Group. ( 21357792 )
2011
17
Minimal disease in the sentinel lymph node: how to best measure sentinel node micrometastases to predict risk of additional non-sentinel lymph node disease. ( 20532987 )
2010
18
Micrometastatic sentinel lymph node disease: do patients benefit or suffer harm from axillary lymph node dissection? ( 19937389 )
2010
19
Epithelial ovarian cancer relapsing as isolated lymph node disease: natural history and clinical outcome. ( 19077269 )
2008
20
Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature. ( 17916603 )
2007
21
Lymph node disease after radical prostatectomy. ( 17431370 )
2007
22
High-risk cutaneous squamous cell carcinoma of the head and neck: results from 266 treated patients with metastatic lymph node disease. ( 16649220 )
2006
23
Prospective comparative study of integrated positron emission tomography-computed tomography scan compared with remediastinoscopy in the assessment of residual mediastinal lymph node disease after induction chemotherapy for mediastinoscopy-proven stage IIIA-N2 Non-small-cell lung cancer: a Leuven Lung Cancer Group Study. ( 16849747 )
2006
24
Metaanalysis of the significance of matrix metalloproteinases for lymph node disease in patients with head and neck squamous cell carcinoma. ( 15912516 )
2005

Variations for Lymph Node Disease

Expression for Lymph Node Disease

Search GEO for disease gene expression data for Lymph Node Disease.

Pathways for Lymph Node Disease

Pathways related to Lymph Node Disease according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.18 IL6 MMP1 MMP3 TNF
2
Show member pathways
12.04 PGLS SDHA SDHB SDHC SDHD
3 12.03 IL6 MMP1 MMP14 TNF
4
Show member pathways
11.91 SDHA SDHB SDHC SDHD
5 11.84 IL6 MMP1 MMP3 TNF
6 11.79 IL6 MMP14 MMP3 TNF
7
Show member pathways
11.75 SDHA SDHB SDHC SDHD
8
Show member pathways
11.7 MMP1 MMP14 MMP3 TNF
9 11.62 IL6 MMP1 MMP3 TNF
10 11.5 MMP1 MMP14 MMP3
11 11.39 CD40LG IL6 TNF
12 11.33 EPCAM IL6 ITGAE TNF
13 11.08 CD40LG IL6 ITGAE TNF
14
Show member pathways
10.82 CD40LG IL6 MMP1 MMP3 TNF
15 10.71 CRP IL6 TNF

GO Terms for Lymph Node Disease

Cellular components related to Lymph Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 CD40LG CD79A ITGAE TNF
2 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHA SDHB SDHC SDHD

Biological processes related to Lymph Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.63 CRP IL6 TNF
2 electron transport chain GO:0022900 9.61 SDHA SDHB SDHC
3 extracellular matrix disassembly GO:0022617 9.58 MMP1 MMP14 MMP3
4 collagen catabolic process GO:0030574 9.5 MMP1 MMP14 MMP3
5 succinate metabolic process GO:0006105 9.37 SDHA SDHB
6 tricarboxylic acid cycle GO:0006099 9.35 SDHA SDHAF2 SDHB SDHC SDHD
7 negative regulation of lipid storage GO:0010888 9.33 CRP IL6 TNF
8 regulation of immunoglobulin secretion GO:0051023 9.26 CD40LG TNF
9 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.92 SDHA SDHAF2 SDHC SDHD

Molecular functions related to Lymph Node Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.46 SDHA SDHB SDHC SDHD
2 ubiquinone binding GO:0048039 9.26 SDHB SDHD
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.13 SDHA SDHB SDHD
4 succinate dehydrogenase activity GO:0000104 8.8 SDHA SDHC SDHD

Sources for Lymph Node Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....