Aliases & Classifications for Lymphadenitis

Summaries for Lymphadenitis

MalaCards based summary : Lymphadenitis, also known as chronic lymphadenitis, is related to appendicitis and mycobacterium fortuitum, and has symptoms including signs and symptoms of ill-defined conditions, syncope and nausea and vomiting. An important gene associated with Lymphadenitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Lymphadenitis

Diseases related to Lymphadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 415)
# Related Disease Score Top Affiliating Genes
1 appendicitis 30.4 CXCL8 IL10 IL1B TNF
2 mycobacterium fortuitum 30.2 CXCL8 IL12RB1
3 mixed connective tissue disease 30.2 IFNG IL10 TNF
4 adult-onset still's disease 30.0 IL18 IL1B TNF
5 chronic granulomatous disease 30.0 IFNG IL1B TNF
6 acquired immunodeficiency syndrome 29.9 IFNG IL10 IL1B TNF
7 tonsillitis 29.9 CXCL8 IFNG IL1B TNF
8 meningitis 29.9 CXCL8 IFNG IL10 IL1B TNF
9 cysticercosis 29.9 IL18 IL1B TLR4
10 hemophagocytic lymphohistiocytosis 29.8 CXCL8 IFNG IL10 IL18 TNF
11 aseptic meningitis 29.7 CXCL8 IFNG IL10 IL1B TNF
12 duodenal ulcer 29.7 CXCL8 IL1B TNF
13 endocarditis 29.7 CXCL8 IL10 TNF
14 myasthenia gravis 29.7 IFNG IL10 TNF
15 schistosomiasis 29.7 IFNG IFNGR1 IL10 TNF
16 melioidosis 29.6 IFNG IL10 IL18 TLR4 TNF
17 prostatitis 29.6 CXCL8 IL10 IL1B TNF
18 toxoplasmosis 29.6 IFNG IL10 IL1B TLR4 TNF
19 cutaneous lupus erythematosus 29.6 CXCR3 ICAM1 IL18 TNF
20 pneumonia 29.6 CXCL8 IL10 IL1B TLR4 TNF
21 ileitis 29.5 NOD2 TLR4 TNF
22 pleurisy 29.5 CXCL8 ICAM1 IFNG TNF
23 osteomyelitis 29.4 CXCL8 IFNG IFNGR1 IL10 IL1B TNF
24 human immunodeficiency virus type 1 29.2 CCR7 CD209 IFNG IL10 TNF
25 otitis media 29.2 CXCL8 IL10 IL1B TLR4 TNF
26 peritonitis 29.2 CXCL8 ICAM1 IFNG IL10 IL1B TNF
27 erythema multiforme 29.1 CXCR3 FASLG ICAM1 IFNG TNF
28 chlamydia 29.0 CXCL8 IFNG IL10 IL1B TLR4 TNF
29 pulmonary tuberculosis 28.9 IFNG IFNGR1 IL10 IL12RB1 IL18 SLC11A1
30 salmonellosis 28.8 IFNG IFNGR1 IL12RB1 IL18 IL1B SLC11A1
31 systemic lupus erythematosus 28.6 CXCR3 FASLG ICAM1 IFNG IL10 IL18
32 leprosy 3 28.5 CD209 IFNG IL10 NOD2 SLC11A1 TNF
33 mycobacterium tuberculosis 1 28.4 CCR7 CD209 CXCR3 IFNG IFNGR1 IL10
34 colitis 28.3 CXCL8 IFNG IL10 IL1B NOD2 TLR4
35 arthritis 28.2 CXCL8 IFNG IL10 IL18 IL1B NOD2
36 ulcerative colitis 28.0 CXCL8 IFNG IL10 IL1B NOD2 TLR4
37 periodic fever, aphthous stomatitis, pharyngitis and adenitis 12.3
38 mesenteric lymphadenitis 12.3
39 kikuchi disease 12.2
40 suppurative lymphadenitis 12.1
41 postauricular lymphadenitis 11.9
42 kawasaki disease 11.2
43 lymphogranuloma venereum 11.2
44 mycobacterium malmoense 11.2
45 submandibular adenitis 11.0
46 cervical adenitis 11.0
47 o'nyong'nyong fever 10.9
48 filarial elephantiasis 10.9
49 axillary adenitis 10.9
50 punctate inner choroidopathy 10.6 IL10 TNF

Comorbidity relations with Lymphadenitis via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Lymphadenitis:



Diseases related to Lymphadenitis

Symptoms & Phenotypes for Lymphadenitis

UMLS symptoms related to Lymphadenitis:


signs and symptoms of ill-defined conditions, syncope, nausea and vomiting, (non-specific) malaise and fatigue, fever of unknown origin, adenitis, abdominal pain

GenomeRNAi Phenotypes related to Lymphadenitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 NOD2 TNF CASP3 CXCL8 ICAM1 IL10
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 NOD2 TNF CASP3 CXCL8 ICAM1 IL10

MGI Mouse Phenotypes related to Lymphadenitis:

43 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.43 NOD2 SLC11A1 SOCS1 TLR4 TNF CASP3
2 immune system MP:0005387 10.42 SLC11A1 SOCS1 TLR4 TNF CASP3 CCL22
3 homeostasis/metabolism MP:0005376 10.39 CASP3 CCR7 CXCR3 FASLG ICAM1 IFNG
4 digestive/alimentary MP:0005381 10.36 CASP3 CCR7 FASLG ICAM1 IFNG IFNGR1
5 cardiovascular system MP:0005385 10.35 CASP3 CXCR3 FASLG ICAM1 IFNG IFNGR1
6 cellular MP:0005384 10.34 IFNG IFNGR1 IL10 IL18 NOD2 TLR4
7 mortality/aging MP:0010768 10.31 TLR4 TNF CASP3 CCL22 CXCR3 FASLG
8 integument MP:0010771 10.22 CASP3 FASLG ICAM1 IFNG IFNGR1 IL10
9 endocrine/exocrine gland MP:0005379 10.19 CASP3 CCR7 FASLG ICAM1 IFNG IFNGR1
10 neoplasm MP:0002006 10.11 TNF CXCR3 FASLG ICAM1 IFNG IFNGR1
11 nervous system MP:0003631 10.06 IFNGR1 IL10 IL18 IL1B TLR4 TNF
12 muscle MP:0005369 10.01 CASP3 ICAM1 IFNG IL10 IL18 SOCS1
13 liver/biliary system MP:0005370 10 FASLG IFNG IFNGR1 IL10 SOCS1 TLR4
14 renal/urinary system MP:0005367 9.8 IFNGR1 SOCS1 TLR4 CASP3 CXCR3 FASLG
15 respiratory system MP:0005388 9.76 CASP3 CXCR3 FASLG IFNG IL10 SOCS1
16 skeleton MP:0005390 9.61 CASP3 FASLG IFNG IFNGR1 IL10 IL1B
17 vision/eye MP:0005391 9.32 CASP3 CCR7 FASLG ICAM1 IFNG IL10

Drugs & Therapeutics for Lymphadenitis

Drugs for Lymphadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 53477736 447043 55185
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3 Anti-Inflammatory Agents Phase 4,Phase 3
4 Antineoplastic Agents, Hormonal Phase 4,Phase 3
5 glucocorticoids Phase 4,Phase 3
6 Hormone Antagonists Phase 4,Phase 3
7 Hormones Phase 4,Phase 3
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
9
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
10
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
11
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
12
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
13 Anti-Bacterial Agents Phase 3
14 Anti-Infective Agents Phase 3
15 Amoxicillin-Potassium Clavulanate Combination Phase 3
16 beta-Lactamase Inhibitors Phase 3
17 Clavulanic Acid Phase 3
18 Gentamicins Phase 3
19 Antimalarials Phase 3
20 Antiparasitic Agents Phase 3
21 Antiprotozoal Agents Phase 3
22 Antibiotics, Antitubercular Phase 3
23 Antiemetics Phase 3
24 Autonomic Agents Phase 3
25 Gastrointestinal Agents Phase 3
26 Methylprednisolone acetate Phase 3
27 Methylprednisolone Hemisuccinate Phase 3
28 Neuroprotective Agents Phase 3
29 Peripheral Nervous System Agents Phase 3
30 Prednisolone acetate Phase 3
31 Prednisolone hemisuccinate Phase 3
32 Prednisolone phosphate Phase 3
33 Protective Agents Phase 3
34 Antibodies Phase 1
35 Antibodies, Monoclonal Phase 1
36 Immunoglobulins Phase 1
37
Ethanol Approved 64-17-5 702
38
Formaldehyde Approved, Vet_approved 50-00-0 712
39 Disinfectants

Interventional clinical trials:

(show all 17)

# Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Recruiting NCT03132116 Phase 3 gentamicin;placebo
3 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Recruiting NCT02929134 Phase 3 Doxycycline;Placebo
4 Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone Recruiting NCT02281929 Phase 3 Amoxicillin;Placebo;Prednisolone
5 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3 Doxycycline;Placebo
6 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Not yet recruiting NCT02927496 Phase 3 Doxycycline;Placebo
7 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3 Methylprednisoline
8 Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Withdrawn NCT02535962 Phase 2
9 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Not yet recruiting NCT02775994 Phase 1 Canakinumab
10 Linear Endosonography for the Assessment of Sarcoidosis Stage O Unknown status NCT01383226
11 Ultrasonographic Differentiation Between Kikuchi's Disease and Lymphoma in Patients With Cervical Lymphadenopathy Unknown status NCT01310933
12 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275 Amoxicillin and clavulanate
13 Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion Completed NCT01560078
14 Tonsillotomy or Follow-up in PFAPA Syndrome Recruiting NCT03331497
15 Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies Recruiting NCT03349814
16 Diagnostic Accuracy of Polymerase Chain Reaction for Mycobacterium Tuberculosis Using EBUS-TBNA Samples Recruiting NCT02497079
17 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445

Search NIH Clinical Center for Lymphadenitis

Cochrane evidence based reviews: lymphadenitis

Genetic Tests for Lymphadenitis

Anatomical Context for Lymphadenitis

MalaCards organs/tissues related to Lymphadenitis:

38
Lymph Node, Testes, Skin, T Cells, Thyroid, B Cells, Myeloid

Publications for Lymphadenitis

Articles related to Lymphadenitis:

(show top 50) (show all 832)
# Title Authors Year
1
Lymphadenitis associated with cat-scratch disease simulating a neoplasm: Imaging findings with histopathological associations. ( 29399138 )
2018
2
Evaluation of loop mediated isothermal amplification (LAMP) assay in the diagnosis of tubercular lymphadenitis: A pilot study. ( 29332654 )
2018
3
Cervicofacial lymphadenitis due to<i>Mycobacterium mantenii:</i>rapid and reliable identification by MALDI-TOF MS. ( 29348923 )
2018
4
Lymphadenitis and Lymphadenopathy. ( 29131085 )
2018
5
Epitrochlear lymphadenitis mimicking subcutaneous abscess. ( 29444798 )
2018
6
Syphilitic lymphadenitis with abscess formation involving cervical lymph nodes. ( 29438971 )
2018
7
Association of Corynebacterium pseudotuberculosis recombinant proteins rCP09720 or rCP01850 with rPLD as immunogens in caseous lymphadenitis immunoprophylaxis. ( 29174312 )
2018
8
Severe Disseminated Necrotizing and Granulomatous Lymphadenitis and Encephalitis in a Dog Due to Sporotrichum pruinosum (Teleomorph: Phanerochaete chrysosporium). ( 29191132 )
2018
9
Conservative treatment for cutaneous fistula resulted from abscess formation in patients with tuberculous cervical lymphadenitis. ( 29402607 )
2018
10
Mycobacterium lentiflavum as the main cause of lymphadenitis in pediatric population. ( 29395439 )
2018
11
Atypical Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis simulating lymphadenitis on<sup>18</sup>F-FDG PET/CT and its differential diagnosis. ( 29177266 )
2017
12
Superior Vena Cava Syndrome Due to Mediastinal Tuberculous Lymphadenitis. ( 28572894 )
2017
13
Differences in clinical manifestations of odontogenic and non-odontogenic lymphadenitis. ( 29203744 )
2017
14
Mycobacterium kansasii Pneumonia with Mediastinal Lymphadenitis in a Patient with Acute Myeloid Leukemia: Successful Treatment to Stem Cell Transplantation. ( 28271647 )
2017
15
Fine-needle aspiration cytology of leishmanial lymphadenitis in a HIV reactive patient. ( 28937392 )
2017
16
Case Report of Ipilimumab-Induced Diffuse, Nonnecrotizing Granulomatous Lymphadenitis and Granulomatous Vasculitis. ( 29279030 )
2017
17
Report of a rare case of histiocytic necrotizing lymphadenitis with bilateral pleural effusion diagnosed via cervical lymph node biopsy. ( 28767989 )
2017
18
Nine patients with chronic granulomatous disease having selective neck dissection for severe cervical lymphadenitis. ( 28727298 )
2017
19
Course of acute nonspecific mesenteric lymphadenitis: single-center experience. ( 28913615 )
2017
20
Hodgkin's lymphoma masquerading as suppurative lymphadenitis. ( 28701837 )
2017
21
Bronchoesophageal fistula due to metastatic mediastinal lymphadenitis. ( 28922703 )
2017
22
Children with lymphadenitis associated with Bacillus Calmette-GuAcrin (BCG) vaccination do not experience more infections when compared with BCG-vaccinated children without lymphadenitis: a three years paired-cohort in Mexico. ( 29201375 )
2017
23
Mycobacterium orygis Lymphadenitis in New York, USA. ( 28930016 )
2017
24
A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum. ( 28822097 )
2017
25
Performance of nested multiplex PCR assay targeting MTP40 and IS6110 gene sequences for the diagnosis of tubercular lymphadenitis. ( 28035600 )
2017
26
Acute Nonspecific Mesenteric Lymphadenitis: More Than "No Need for Surgery". ( 28261620 )
2017
27
The predominance of Ethiopian specific Mycobacterium tuberculosis families and minimal contribution of Mycobacterium bovis in tuberculous lymphadenitis patients in Southwest Ethiopia. ( 28919549 )
2017
28
BCG vaccination-induced suppurative lymphadenitis: four signs to pay attention to. ( 28425207 )
2017
29
Dermatopathic Lymphadenitis Mimicking Breast Cancer with Lymphatic Metastasis: A Case Report and Discussion. ( 29238033 )
2017
30
Facial and limb angioedema with parotitis and Kikuchi-like necrotizing lymphadenitis preceding neuropsychiatric systemic lupus erythematosus in a young African American male. ( 28849689 )
2017
31
An HIV-positive Case of Obstructive Jaundice Caused by Immune Reconstitution Inflammatory Syndrome of Tuberculous Lymphadenitis Successfully Treated with Corticosteroids. ( 28883243 )
2017
32
Comparison of Conventional Ziehl-Neelsen Method of Acid Fast Bacilli with Modified Bleach Method in Tuberculous Lymphadenitis. ( 29118472 )
2017
33
Mesenteric lymphadenitis as a presenting feature of Whipple's disease. ( 28660130 )
2017
34
Clinicopathological features of cryptococcal lymphadenitis and a review of literature. ( 28592745 )
2017
35
Characteristics of mesenteric lymphadenitis in comparison with those of acute appendicitis in children. ( 27987102 )
2017
36
Concentration of fine needle aspirates similar to molecular method improves sensitivity of the diagnosis of tuberculous lymphadenitis in Addis Ababa, Ethiopia. ( 28088186 )
2017
37
Cytomorphological patterns of tubercular lymphadenitis and its comparison with Ziehl-Neelsen staining and culture in eastern up. (Gorakhpur region): Cytological study of 400 cases. ( 28701826 )
2017
38
Histiocytic necrotizing lymphadenitis (Kikuchi's disease) with vasculitis. ( 29178301 )
2017
39
The diagnostic activity on wild animals through the description of a model case report (caseous lymphadenitis by<i>Corynebacterium pseudotuberculosis</i>associated with<i>Pasteurella</i>spp and parasites infection in an alpine ibex -<i>Capra ibex</i>). ( 29392118 )
2017
40
Clinical and cytological features in diagnosis of peripheral tubercular lymphadenitis - A hospital-based study from central India. ( 28941854 )
2017
41
Infantile incomplete Kawasaki disease mimicking cervical purulent lymphadenitis with coronary artery aneurysm. ( 28786205 )
2017
42
Villada G, Vega F. Clusters of paracortical plasmacytoid dendritic cells in lupus lymphadenitis. Blood. 2017;129(13):1884. ( 28596440 )
2017
43
Mandibular Osteomyelitis and Cervical Lymphadenitis Due to Mycobacterium abscessus: Surgical Management of a Pediatric Cohort With a Shared Epidemiologic Exposure. ( 28938329 )
2017
44
Shifting trend of tubercular lymphadenitis over aA decade - A study from eastern region of India. ( 29179883 )
2017
45
The diagnostic accuracy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in mediastinal tuberculous lymphadenitis ( 29306252 )
2017
46
Prevalence of tuberculous lymphadenitis in slaughtered cattle in Eastern Cape, South Africa. ( 28552545 )
2017
47
Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma. ( 27051539 )
2016
48
Reduced systemic and mycobacterial antigen-stimulated concentrations of IL-1I^ and IL-18 in tuberculous lymphadenitis. ( 27794266 )
2016
49
A clinical review of 38 cases of cervical tuberculous lymphadenitis in Japan - The role of neck dissection. ( 26856305 )
2016
50
Diagnostic challenges in cervical tuberculous lymphadenitis: A review. ( 28058405 )
2016

Variations for Lymphadenitis

Expression for Lymphadenitis

Search GEO for disease gene expression data for Lymphadenitis.

Pathways for Lymphadenitis

Pathways related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 CASP3 CCL22 CD209 CXCL8 FASLG ICAM1
2
Show member pathways
13.94 CASP3 CCL22 CCR7 CXCL8 CXCR3 FASLG
3
Show member pathways
13.67 CCL22 CXCL8 ICAM1 IFNG IFNGR1 IL10
4
Show member pathways
13.67 CASP3 CCL22 CCR7 CXCL8 CXCR3 FASLG
5
Show member pathways
13.54 CASP3 CCL22 CCR7 CXCL8 CXCR3 FASLG
6
Show member pathways
13.43 CASP3 CCL22 CCR7 CXCL8 CXCR3 FASLG
7
Show member pathways
13.36 CASP3 CCL22 CXCL8 FASLG ICAM1 IFNG
8
Show member pathways
13.1 CD209 CXCL8 IL18 IL1B NOD2 TLR4
9
Show member pathways
12.99 CASP3 CXCL8 FASLG ICAM1 IFNG IL10
10 12.94 CASP3 CXCL8 FASLG IFNG IFNGR1 IL12RB1
11
Show member pathways
12.87 CASP3 CD209 CXCL8 FASLG ICAM1 IFNG
12
Show member pathways
12.8 CASP3 FASLG IFNG IFNGR1 IL1B TNF
13
Show member pathways
12.79 CXCL8 IFNG IL18 IL1B TNF
14
Show member pathways
12.77 IFNG IFNGR1 IL10 IL12RB1 IL18 TNF
15
Show member pathways
12.73 IFNG IL10 IL12RB1 IL18 IL1B TNF
16
Show member pathways
12.73 CASP3 CXCL8 FASLG ICAM1 IFNGR1 TLR4
17
Show member pathways
12.73 IFNG IFNGR1 IL10 IL12RB1 IL18 IL1B
18 12.71 FASLG IFNG IL10 IL1B SOCS1 TNF
19
Show member pathways
12.69 CASP3 FASLG IL1B TLR4 TNF
20
Show member pathways
12.69 CXCL8 FASLG IFNG IFNGR1 IL10 IL1B
21
Show member pathways
12.67 CASP3 FASLG ICAM1 IFNG IFNGR1 TNF
22
Show member pathways
12.5 IFNG IFNGR1 IL10 IL12RB1 SOCS1
23
Show member pathways
12.48 IFNG IL10 IL1B TNF
24
Show member pathways
12.47 CASP3 CXCL8 IFNG IL1B TNF
25
Show member pathways
12.42 CXCL8 IFNG IFNGR1 IL1B TLR4 TNF
26
Show member pathways
12.4 ICAM1 IFNG IL1B TNF
27
Show member pathways
12.4 CASP3 IFNG IFNGR1 IL10 IL1B SOCS1
28
Show member pathways
12.38 FASLG IFNG IFNGR1 IL1B TLR4 TNF
29 12.37 CASP3 FASLG TLR4 TNF
30
Show member pathways
12.35 CXCL8 FASLG IFNG IFNGR1 IL1B TLR4
31 12.34 CASP3 IFNG IFNGR1 TLR4 TNF
32 12.33 CASP3 CXCL8 IL10 IL1B TNF
33
Show member pathways
12.33 CXCL8 IFNG IL10 IL18 IL1B SOCS1
34
Show member pathways
12.26 CCL22 CCR7 CXCL8 CXCR3 ICAM1
35 12.21 IFNG IFNGR1 IL1B SOCS1 TNF
36 12.19 ICAM1 IFNG IL1B TNF
37 12.17 CASP3 CXCL8 ICAM1 IFNG IL1B TLR4
38 12.16 CCR7 CD209 IFNG IL10 TNF
39
Show member pathways
12.16 FASLG IFNG IL12RB1 IL18 IL1B SOCS1
40 12.13 CASP3 ICAM1 IL1B NOD2 TNF
41
Show member pathways
12.11 CCL22 CCR7 CXCL8 CXCR3
42 12.08 CASP3 CXCL8 ICAM1 IL1B TNF
43 12.05 CXCL8 ICAM1 IL1B TLR4 TNF
44 12.04 CASP3 CXCL8 IFNG IL10 IL1B TLR4
45
Show member pathways
12.03 CCR7 IFNG IL12RB1 IL1B TLR4
46 12.02 IFNG IFNGR1 IL10 IL12RB1 SOCS1
47 12.02 CXCL8 IFNG IFNGR1 IL18 IL1B TLR4
48 12.01 CASP3 CXCL8 IL18 TLR4
49
Show member pathways
12.01 CXCL8 ICAM1 IL12RB1 TLR4
50
Show member pathways
12.01 IFNG IFNGR1 IL1B SOCS1

GO Terms for Lymphadenitis

Cellular components related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 CCL22 CD209 CXCL8 FASLG IFNG IL10
2 extracellular space GO:0005615 9.81 CCL22 CXCL8 FASLG ICAM1 IFNG IL10
3 membrane raft GO:0045121 9.56 CASP3 FASLG ICAM1 TNF
4 cell surface GO:0009986 9.56 CCR7 CD209 CXCR3 FASLG ICAM1 NOD2
5 external side of plasma membrane GO:0009897 9.17 CCR7 CD209 CXCR3 FASLG ICAM1 TLR4

Biological processes related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.98 CCL22 CCR7 CXCL8 CXCR3
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 ICAM1 IL1B NOD2 TLR4 TNF
3 regulation of receptor activity GO:0010469 9.97 CCL22 CXCL8 FASLG IFNG IL10 IL18
4 cellular response to lipopolysaccharide GO:0071222 9.96 CXCL8 ICAM1 IL10 TLR4 TNF
5 activation of MAPK activity GO:0000187 9.95 IL1B NOD2 TLR4 TNF
6 response to virus GO:0009615 9.94 CCL22 IFNG IFNGR1 TNF
7 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.93 CCR7 FASLG IL1B NOD2 TLR4 TNF
8 cellular response to interferon-gamma GO:0071346 9.92 CCL22 ICAM1 IL12RB1
9 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.92 CASP3 FASLG TNF
10 movement of cell or subcellular component GO:0006928 9.91 CXCL8 CXCR3 IFNG
11 chemokine-mediated signaling pathway GO:0070098 9.91 CCL22 CCR7 CXCL8 CXCR3
12 apoptotic signaling pathway GO:0097190 9.91 CASP3 FASLG TLR4 TNF
13 cellular response to interleukin-1 GO:0071347 9.9 CCL22 CXCL8 ICAM1
14 regulation of inflammatory response GO:0050727 9.9 NOD2 TLR4 TNF
15 interferon-gamma-mediated signaling pathway GO:0060333 9.9 ICAM1 IFNG IFNGR1
16 regulation of insulin secretion GO:0050796 9.89 IFNG IL1B TNF
17 neutrophil chemotaxis GO:0030593 9.89 CCL22 CXCL8 IL1B
18 response to glucocorticoid GO:0051384 9.88 CASP3 IL10 TNF
19 cellular response to organic cyclic compound GO:0071407 9.88 CASP3 IL18 IL1B NOD2 TNF
20 interleukin-12-mediated signaling pathway GO:0035722 9.87 IFNG IL10 IL12RB1
21 positive regulation of interleukin-6 production GO:0032755 9.87 IL1B NOD2 TLR4 TNF
22 response to lipopolysaccharide GO:0032496 9.86 CASP3 CCR7 FASLG ICAM1 IL10 IL1B
23 regulation of cell adhesion GO:0030155 9.85 CXCL8 ICAM1 IL18
24 extrinsic apoptotic signaling pathway GO:0097191 9.85 FASLG IFNG TNF
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.84 IL18 IL1B TLR4 TNF
26 cellular response to organic substance GO:0071310 9.83 CASP3 ICAM1 IL1B
27 positive regulation of phagocytosis GO:0050766 9.83 IL1B SLC11A1 TNF
28 positive regulation of JNK cascade GO:0046330 9.83 CCR7 IL1B NOD2 TLR4 TNF
29 negative regulation of interleukin-6 production GO:0032715 9.81 IL10 TLR4 TNF
30 positive regulation of interleukin-8 production GO:0032757 9.81 IL1B NOD2 TLR4 TNF
31 positive regulation of interleukin-12 production GO:0032735 9.8 CCR7 IFNG TLR4
32 positive regulation of NF-kappaB import into nucleus GO:0042346 9.8 IL18 IL1B TLR4 TNF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.77 IFNG IL1B TNF
34 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.77 IFNG IFNGR1 SOCS1
35 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.76 IL10 IL1B TNF
36 positive regulation of interleukin-17 production GO:0032740 9.75 IL18 NOD2
37 response to molecule of bacterial origin GO:0002237 9.74 CXCL8 IL10
38 regulation of cytokine secretion GO:0050707 9.74 SOCS1 TLR4
39 T-helper 1 type immune response GO:0042088 9.74 IL18 TLR4
40 interferon-gamma production GO:0032609 9.74 IL18 TLR4
41 neutrophil activation GO:0042119 9.74 CXCL8 IL18
42 negative regulation of interleukin-17 production GO:0032700 9.73 IFNG TLR4
43 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.73 IL18 IL1B
44 macrophage activation GO:0042116 9.73 SLC11A1 TLR4
45 positive regulation of T-helper 1 type immune response GO:0002827 9.72 IL12RB1 SLC11A1
46 positive regulation of chemokine biosynthetic process GO:0045080 9.72 IL1B TNF
47 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.72 CCR7 NOD2 SLC11A1
48 positive regulation of nitric oxide biosynthetic process GO:0045429 9.72 ICAM1 IFNG IL1B TLR4 TNF
49 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TLR4 TNF
50 endothelial cell apoptotic process GO:0072577 9.71 IL10 TNF

Molecular functions related to Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL22 CXCL8 FASLG IFNG IL10 IL18

Sources for Lymphadenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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