MCID: LYM021
MIFTS: 58

Lymphadenitis malady

Categories: Skin diseases, Immune diseases

Aliases & Classifications for Lymphadenitis

Summaries for Lymphadenitis

MalaCards based summary : Lymphadenitis, also known as chronic lymphadenitis, is related to tuberculosis and tularemia, and has symptoms including abdominal pain, adenitis and fever of unknown origin. An important gene associated with Lymphadenitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, breast and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Related Diseases for Lymphadenitis

Diseases related to Lymphadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 397)
id Related Disease Score Top Affiliating Genes
1 tuberculosis 30.8 IL10 IL1B TNF
2 tularemia 30.3 IFNG IL10 TNF
3 hepatitis 29.5 IFNG IL10 TNF
4 histiocytosis 29.4 CXCL8 IL1B TLR4 TNF
5 pulmonary tuberculosis 29.4 CXCL8 IFNG IL10 TLR4 TNF
6 microcephaly 29.1 ICAM1 IFNG IFNGR1 IL10 IL12RB1 TNF
7 periodic fever, aphthous stomatitis, pharyngitis and adenitis 12.2
8 mesenteric lymphadenitis 12.1
9 kikuchi disease 12.0
10 suppurative lymphadenitis 12.0
11 postauricular lymphadenitis 11.8
12 mycobacterium malmoense 11.1
13 lymphogranuloma venereum 11.1
14 kawasaki disease 11.1
15 submandibular adenitis 10.9
16 cervical adenitis 10.9
17 pestis minor 10.8
18 o'nyong'nyong fever 10.8
19 filarial elephantiasis 10.8
20 axillary adenitis 10.8
21 cervicitis 10.4
22 intussusception 10.4 IL1B TNF
23 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
24 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.3 IFNG IL10 TNF
25 psoriatic arthritis 10.3 IL18 NOD2 TNF
26 stocco dos santos syndrome 10.3 IFNG IL1B TNF
27 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 TNF
28 hemangioma of intra-abdominal structure 10.3 FASLG IFNG
29 intravascular papillary endothelial hyperplasia 10.3 IFNG IFNGR1
30 tau syndrome 10.3 IL18 IL1B TNF
31 pancreatic signet ring cell adenocarcinoma 10.3 IFNG IL10 TNF
32 pseudo-meigs syndrome 10.3 FASLG IL10 TNF
33 meier-gorlin syndrome 3 10.3 IL1B NOD2 TNF
34 pulpitis 10.3 IFNG IL10 TNF
35 female reproductive system disease 10.3 IL12RB1 NOD2 TNF
36 rosacea 10.3 IFNG IL10 IL1B
37 leptospirosis 10.3 IL12RB1 NOD2 TNF
38 steroid dehydrogenase deficiency dental anomalies 10.3 IL18 IL1B TNF
39 red cell phospholipid defect with hemolysis 10.3 IFNG IL18 TNF
40 giant cell glioblastoma 10.3 IFNG IFNGR1 IL1B
41 plummer's disease 10.3 IFNG IL10 TNF
42 benign neonatal seizures 10.3 IL18 IL1B TNF
43 orbital osteomyelitis 10.3 IFNG IL10 TNF
44 gonococcal endophthalmia 10.3 IL10 IL1B TNF
45 disease of mental health 10.3 IFNG IL10 TNF
46 follicular adenoma 10.3 IFNG IL10 TNF
47 hypotrichosis 4 10.3 ICAM1 IFNG TNF
48 bladder signet ring cell adenocarcinoma 10.3 IL10 IL1B TNF
49 esophagus lymphoma 10.2 CXCL8 IFNG TNF
50 central nervous system lymphoma 10.2 IL10 IL1B TNF

Comorbidity relations with Lymphadenitis via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Lymphadenitis:



Diseases related to Lymphadenitis

Symptoms & Phenotypes for Lymphadenitis

UMLS symptoms related to Lymphadenitis:


abdominal pain, adenitis, fever of unknown origin, (non-specific) malaise and fatigue, nausea and vomiting, syncope, signs and symptoms of ill-defined conditions

GenomeRNAi Phenotypes related to Lymphadenitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 IL1B CASP3 NOD2 CXCL8 TNF ICAM1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 IL1B CASP3 NOD2 CXCL8 TNF FASLG

MGI Mouse Phenotypes related to Lymphadenitis:

44 (show all 17)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.43 TLR4 TNF CASP3 CCR7 CXCR3 FASLG
2 immune system MP:0005387 10.4 CASP3 CCR7 CXCR3 FASLG ICAM1 IFNG
3 homeostasis/metabolism MP:0005376 10.39 IFNG IFNGR1 IL10 IL12RB1 IL18 IL1B
4 cellular MP:0005384 10.37 NOD2 STAT3 TLR4 TNF CASP3 CCR7
5 digestive/alimentary MP:0005381 10.36 CASP3 CCR7 FASLG ICAM1 IFNG IFNGR1
6 cardiovascular system MP:0005385 10.35 CASP3 CXCR3 FASLG ICAM1 IFNG IFNGR1
7 mortality/aging MP:0010768 10.31 IFNGR1 IL10 IL18 IL1B NOD2 SLC11A1
8 integument MP:0010771 10.22 CASP3 FASLG ICAM1 IFNG IFNGR1 IL10
9 endocrine/exocrine gland MP:0005379 10.19 CASP3 CCR7 FASLG ICAM1 IFNG IFNGR1
10 neoplasm MP:0002006 10.11 TNF CXCR3 FASLG ICAM1 IFNG IFNGR1
11 nervous system MP:0003631 10.1 CASP3 CCR7 FASLG ICAM1 IFNG IFNGR1
12 muscle MP:0005369 10.01 CASP3 ICAM1 IFNG IL10 IL18 STAT3
13 liver/biliary system MP:0005370 10 TNF FASLG IFNG IFNGR1 IL10 STAT3
14 renal/urinary system MP:0005367 9.8 CASP3 CXCR3 FASLG IFNG IFNGR1 STAT3
15 respiratory system MP:0005388 9.76 IFNG IL10 STAT3 TLR4 TNF CASP3
16 skeleton MP:0005390 9.65 CASP3 FASLG IFNG IFNGR1 IL10 IL1B
17 vision/eye MP:0005391 9.32 CASP3 CCR7 FASLG ICAM1 IFNG IL10

Drugs & Therapeutics for Lymphadenitis

Drugs for Lymphadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 53477736 447043
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3 Anti-Inflammatory Agents Phase 4,Phase 3
4 Antineoplastic Agents, Hormonal Phase 4,Phase 3
5 glucocorticoids Phase 4,Phase 3
6 Hormone Antagonists Phase 4,Phase 3
7 Hormones Phase 4,Phase 3
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
9
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
10
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
12
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
13 Amoxicillin-Potassium Clavulanate Combination Phase 3
14 Anti-Bacterial Agents Phase 3
15 Anti-Infective Agents Phase 3
16 beta-Lactamase Inhibitors Phase 3
17 Clavulanic Acid Phase 3
18 Antibiotics, Antitubercular Phase 3
19 Antiemetics Phase 3
20 Autonomic Agents Phase 3
21 Gastrointestinal Agents Phase 3
22 Methylprednisolone acetate Phase 3
23 Methylprednisolone Hemisuccinate Phase 3
24 Neuroprotective Agents Phase 3
25 Peripheral Nervous System Agents Phase 3
26 Prednisolone acetate Phase 3
27 Prednisolone hemisuccinate Phase 3
28 Prednisolone phosphate Phase 3
29 Protective Agents Phase 3
30 Gentamicins Phase 3
31 Antimalarials Phase 3
32 Antiparasitic Agents Phase 3
33 Antiprotozoal Agents Phase 3
34 Acidophilus Nutraceutical Phase 2
35 Bifidobacterium Nutraceutical Phase 2
36 Antibodies Phase 1
37 Antibodies, Monoclonal Phase 1
38 Immunoglobulins Phase 1
39
Ethanol Approved 64-17-5 702
40
Formaldehyde Approved, Vet_approved 50-00-0 712
41 Disinfectants

Interventional clinical trials:

(show all 15)
id Name Status NCT ID Phase
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4
2 Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone Recruiting NCT02281929 Phase 3
3 Intra-nodal Injection of Gentamicin for the Treatment of Suppurated Cat Scratch Disease's Lymphadenitis Not yet recruiting NCT03132116 Phase 3
4 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Not yet recruiting NCT02929134 Phase 3
5 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3
6 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Not yet recruiting NCT02927496 Phase 3
7 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3
8 Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Not yet recruiting NCT02535962 Phase 2
9 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Not yet recruiting NCT02775994 Phase 1
10 Linear Endosonography for the Assessment of Sarcoidosis Stage O Unknown status NCT01383226
11 Ultrasonographic Differentiation Between Kikuchi's Disease and Lymphoma in Patients With Cervical Lymphadenopathy Unknown status NCT01310933
12 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275
13 Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion Completed NCT01560078
14 Diagnostic Accuracy of Polymerase Chain Reaction for Mycobacterium Tuberculosis Using EBUS-TBNA Samples Recruiting NCT02497079
15 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445

Search NIH Clinical Center for Lymphadenitis

Cochrane evidence based reviews: lymphadenitis

Genetic Tests for Lymphadenitis

Anatomical Context for Lymphadenitis

MalaCards organs/tissues related to Lymphadenitis:

39
Lymph Node, Breast, Testes, T Cells, Skin, Thyroid, B Cells

Publications for Lymphadenitis

Articles related to Lymphadenitis:

(show top 50) (show all 788)
id Title Authors Year
1
Performance of nested multiplex PCR assay targeting MTP40 and IS6110 gene sequences for the diagnosis of tubercular lymphadenitis. ( 28035600 )
2017
2
Characteristics of mesenteric lymphadenitis in comparison with those of acute appendicitis in children. ( 27987102 )
2017
3
Concentration of fine needle aspirates similar to molecular method improves sensitivity of the diagnosis of tuberculous lymphadenitis in Addis Ababa, Ethiopia. ( 28088186 )
2017
4
Cervical Tuberculous Lymphadenitis: Clinico-demographic Profiles of Patients in a Secondary Level Hospital of Bangladesh. ( 27375699 )
2016
5
Fine needle aspiration cytology of dermatopathic lymphadenitis in an asymptomatic female: A case report. ( 27011445 )
2016
6
Diagnostic challenges in cervical tuberculous lymphadenitis: A review. ( 28058405 )
2016
7
Systemic Kikuchi-Fujimoto disease bordering lupus lymphadenitis: A fresh look? ( 27904829 )
2016
8
Immune Reconstitution Inflammatory Syndrome Presenting as Mycobacterium Avium Complex Lymphadenitis. ( 28000104 )
2016
9
Herpesvirus-Associated Lymphadenitis Distorts Fibroblastic Reticular Cell Microarchitecture and Attenuates CD8 T Cell Responses to Neurotropic Infection in Mice Lacking the STING-IFNI+/I^ Defense Pathways. ( 27511736 )
2016
10
Tuberculous Lymphadenitis and Parotitis. ( 28084205 )
2016
11
Utility of endobronchial ultrasound-guided transbronchial needle aspiration in diagnosing non-specific inflammatory intrathorcacic lymphadenitis. ( 27882677 )
2016
12
Paradoxical reaction (PR) in tuberculous lymphadenitis among HIV-negative patients: retrospective cohort study. ( 27638382 )
2016
13
Suggested Protocol for Managing Acute Suppurative Cervical Lymphadenitis in Children to Reduce Unnecessary Surgical Interventions. ( 27553593 )
2016
14
Tuberculous lymphadenitis of the head and neck in Canadian children: Experience from a low-burden region. ( 27863623 )
2016
15
Is mesenteric lymphadenitis a cause of ovarian reserve reduction? - Case Report. ( 27203306 )
2016
16
Tuberculous lymphadenitis: Comparison of cytomorphology, Ziehl-Neelsen staining, and rapid mycobacterial culture at a pediatric superspecialty hospital. ( 27563340 )
2016
17
The genome anatomy of Corynebacterium pseudotuberculosis VD57 a highly virulent strain causing Caseous lymphadenitis. ( 27066196 )
2016
18
Usefulness of Microvascular Ultrasonography in Differentiating Metastatic Lymphadenopathy from Tuberculous Lymphadenitis. ( 27353493 )
2016
19
Similar presentation of cervical lymphadenitis of different etiology in two siblings. ( 27422429 )
2016
20
Cervical US and CT findings of Kawasaki disease: comparison with lymphadenitis. ( 27097838 )
2016
21
Tuberculous Lymphadenitis in South-Eastern Nigeria; A 15 Years Histopathologic Review (2000-2014). ( 27144076 )
2016
22
CT Findings of Axillary Tuberculosis Lymphadenitis: A Case Detected by Breast Cancer Screening Examination. ( 27379192 )
2016
23
Retrospective characterisation and outcome of canine idiopathic mesenteric purulent lymphadenitis and lymph node abscesses at a teaching hospital from 2005 to 2015. ( 27627549 )
2016
24
Disseminated Mycobacterium abscessus Complex Infection Manifesting as Multiple Areas of Lymphadenitis and Skin Abscess in the Preclinical Stage of Acute Lymphocytic Leukemia. ( 27374685 )
2016
25
Coccidioides immitis Cervical Lymphadenitis Complicated by Esophageal Fistula. ( 27313922 )
2016
26
Vaccination against Corynebacterium pseudotuberculosis infections controlling caseous lymphadenitis (CLA) and oedematousskin disease. ( 27872567 )
2016
27
Reduced systemic and mycobacterial antigen-stimulated concentrations of IL-1I^ and IL-18 in tuberculous lymphadenitis. ( 27794266 )
2016
28
Nontuberculous Mycobacteria Lymphadenitis: A Case Report. ( 27909634 )
2016
29
Localized Leishmania Lymphadenitis Etiologic Agent Identified as Leishmania tropica Using Gene Sequencing. ( 27499784 )
2016
30
Tuberculous lymphadenitis in a patient with Good syndrome. ( 27487062 )
2016
31
Histiocytic necrotising lymphadenitis in mediastinum mimicking thymoma or lymphoma - case presentation and literature review of Kikuchi Fujimoto disease. ( 27179280 )
2016
32
Human Immunodeficiency Virus Lymphadenitis Patterns on Fine-Needle Aspiration Cytology. ( 27997883 )
2016
33
Mediastinal Tuberculous Lymphadenitis Diagnosed by Endosonographic Fine Needle Aspiration. ( 28025474 )
2016
34
Establishment of Elevated Serum Levels of IL-10, IL-8 and TNF-I^ as Potential Peripheral Blood Biomarkers in Tubercular Lymphadenitis: A Prospective Observational Cohort Study. ( 26784906 )
2016
35
Patterns of granulomatous responses in TB lymphadenitis and their correlation with treatment outcomes. ( 27865239 )
2016
36
Management of nontuberculous mycobacterial lymphadenitis in a tertiary care children's hospital: A 20year experience. ( 27614809 )
2016
37
Multidrug-Resistant Tuberculous Mediastinal Lymphadenitis, with an Esophagomediastinal Fistula, Mimicking an Esophageal Submucosal Tumor. ( 27087646 )
2016
38
Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma. ( 27051539 )
2016
39
Loop-mediated isothermal amplification (LAMP) assay for speedy diagnosis of tubercular lymphadenitis: The multi-targeted 60-minute approach. ( 27553418 )
2016
40
Clinical Characteristics of Severe Histiocytic Necrotizing Lymphadenitis (Kikuchi-Fujimoto Disease) in Children. ( 26852178 )
2016
41
Peripancreatic Tuberculous Lymphadenitis with Biliary Obstruction Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration Biopsy. ( 27086805 )
2016
42
Novel insights into the early histopathogenesis of immunodeficiency-associated Burkitt lymphoma: A case report of Burkitt microlymphoma arising within HIV lymphadenitis. ( 26953628 )
2016
43
Human herpesvirus 6 (HHV-6B) lymphadenitis in DRESS syndrome: a lymphoma mimic. ( 28008656 )
2016
44
Syphilitic lymphadenitis clinically and histologically mimicking lymphogranuloma venereum. ( 27138664 )
2016
45
A personalised approach is needed for the management of non-tuberculous mycobacterial cervicofacial lymphadenitis. ( 27506394 )
2016
46
Suppurative Cervical Tuberculous Lymphadenitis Mimicking a Metastatic Neck Mass. ( 27428919 )
2016
47
Simultaneous occurrence of Hodgkin's disease and tubercular lymphadenitis in the same cervical lymph node: a rare presentation. ( 26740271 )
2016
48
A case of abdominal tuberculosis lymphadenitis extending into the gallbladder and duodenum in a human T-cell lymphotropic virus type 1 carrier. ( 27264431 )
2016
49
A clinical review of 38 cases of cervical tuberculous lymphadenitis in Japan - The role of neck dissection. ( 26856305 )
2016
50
Hoarse voice: a rare presentation of tuberculosis lymphadenitis. ( 27797813 )
2016

Variations for Lymphadenitis

Expression for Lymphadenitis

Search GEO for disease gene expression data for Lymphadenitis.

Pathways for Lymphadenitis

Pathways related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 88)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.1 CASP3 CCL22 CD209 CXCL8 FASLG ICAM1
2
Show member pathways
13.98 CASP3 CCL22 CCR7 CXCL8 CXCR3 FASLG
3
Show member pathways
13.71 CASP3 CCL22 CCR7 CXCL8 CXCR3 FASLG
4
Show member pathways
13.68 CCL22 CXCL8 ICAM1 IFNG IFNGR1 IL10
5
Show member pathways
13.51 CASP3 CCL22 CCR7 CXCL8 CXCR3 FASLG
6
Show member pathways
13.44 CASP3 CCL22 CCR7 CXCL8 CXCR3 FASLG
7
Show member pathways
13.39 CASP3 CCL22 CXCL8 FASLG ICAM1 IFNG
8
Show member pathways
13.11 CD209 CXCL8 IL18 IL1B NOD2 TLR4
9
Show member pathways
13.06 CASP3 CXCL8 FASLG IFNG IFNGR1 IL10
10
Show member pathways
13 CASP3 CXCL8 FASLG ICAM1 IFNG IL10
11
Show member pathways
12.97 CCL22 CCR7 CXCL8 CXCR3 FASLG STAT3
12
Show member pathways
12.84 CASP3 CD209 CXCL8 FASLG ICAM1 IFNG
13
Show member pathways
12.82 CASP3 FASLG IFNG IFNGR1 IL1B STAT3
14
Show member pathways
12.8 CXCL8 IFNG IL18 IL1B TNF
15
Show member pathways
12.77 IFNG IFNGR1 IL10 IL12RB1 IL18 TNF
16
Show member pathways
12.76 IFNG IL10 IL12RB1 IL18 IL1B STAT3
17
Show member pathways
12.69 CASP3 FASLG IL1B TLR4 TNF
18 12.69 FASLG IFNG IL10 IL1B STAT3 TNF
19
Show member pathways
12.69 IFNG IFNGR1 IL10 IL12RB1 IL18 IL1B
20
Show member pathways
12.67 CASP3 FASLG ICAM1 IFNG IFNGR1 TNF
21
Show member pathways
12.51 CASP3 CXCL8 IFNG IL1B STAT3 TNF
22
Show member pathways
12.48 IFNG IL10 IL1B TNF
23 12.44 CASP3 FASLG STAT3 TLR4 TNF
24
Show member pathways
12.44 CXCL8 IFNG IFNGR1 IL1B TLR4 TNF
25
Show member pathways
12.41 CASP3 IFNG IFNGR1 IL10 IL1B STAT3
26
Show member pathways
12.4 ICAM1 IFNG IL1B TNF
27 12.37 ICAM1 IFNG IL10 STAT3
28
Show member pathways
12.36 IFNG IFNGR1 IL10 IL12RB1 STAT3
29
Show member pathways
12.36 CXCL8 FASLG IFNG IFNGR1 IL1B TLR4
30 12.35 CASP3 IFNG IFNGR1 STAT3 TLR4 TNF
31 12.33 CASP3 CXCL8 IL10 IL1B TNF
32
Show member pathways
12.33 CXCL8 IFNG IL10 IL18 IL1B TNF
33 12.27 CASP3 CD209 IFNG IFNGR1 IL10 IL18
34 12.19 ICAM1 IFNG IL1B TNF
35 12.19 CASP3 CXCL8 ICAM1 IFNG IL1B TLR4
36 12.18 CCR7 CD209 IFNG IL10 TNF
37
Show member pathways
12.17 FASLG IFNG IL12RB1 IL18 IL1B STAT3
38 12.15 IFNG IFNGR1 IL1B TNF
39
Show member pathways
12.13 CCL22 CCR7 CXCL8 CXCR3
40 12.13 CASP3 ICAM1 IL1B NOD2 TNF
41
Show member pathways
12.11 CCR7 IFNG IL12RB1 IL1B STAT3 TLR4
42 12.1 CASP3 CXCL8 ICAM1 IL1B STAT3 TNF
43 12.07 CXCL8 ICAM1 IL1B TLR4 TNF
44
Show member pathways
12.05 CXCL8 ICAM1 IL12RB1 STAT3 TLR4
45 12.05 CASP3 CXCL8 IFNG IL10 IL1B TLR4
46 12.04 IFNG IFNGR1 STAT3 TLR4
47
Show member pathways
12.02 IFNG IFNGR1 IL1B STAT3
48 12.02 CXCL8 IFNG IFNGR1 IL18 IL1B TLR4
49 12.01 CASP3 CXCL8 IL18 TLR4
50 12.01 CXCL8 ICAM1 IFNG IL18 IL1B TLR4

GO Terms for Lymphadenitis

Cellular components related to Lymphadenitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 CCL22 CXCL8 FASLG ICAM1 IFNG IL10
2 membrane raft GO:0045121 9.62 CASP3 FASLG ICAM1 TNF
3 cell surface GO:0009986 9.56 CCR7 CD209 CXCR3 FASLG ICAM1 NOD2
4 external side of plasma membrane GO:0009897 9.28 CCR7 CD209 CXCR3 FASLG ICAM1 IFNG
5 plasma membrane GO:0005886 10.07 CASP3 CCR7 CD209 CXCR3 FASLG ICAM1
6 extracellular region GO:0005576 10.02 CCL22 CD209 CXCL8 FASLG IFNG IL10

Biological processes related to Lymphadenitis according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.99 ICAM1 IL1B NOD2 TLR4 TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.99 CCL22 CCR7 ICAM1 NOD2 TLR4 TNF
3 response to virus GO:0009615 9.98 CCL22 IFNG IFNGR1 TNF
4 activation of MAPK activity GO:0000187 9.97 IL1B NOD2 TLR4 TNF
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 CCR7 FASLG IL1B NOD2 TLR4 TNF
6 response to organic substance GO:0010033 9.95 CASP3 IL10 STAT3 TNF
7 movement of cell or subcellular component GO:0006928 9.94 CXCL8 CXCR3 IFNG STAT3
8 apoptotic signaling pathway GO:0097190 9.94 CASP3 FASLG TLR4 TNF
9 chemokine-mediated signaling pathway GO:0070098 9.93 CCL22 CCR7 CXCL8 CXCR3
10 positive regulation of protein kinase B signaling GO:0051897 9.92 CCR7 IL18 TNF
11 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.92 CASP3 FASLG TNF
12 cellular response to interleukin-1 GO:0071347 9.92 CCL22 CXCL8 ICAM1
13 response to glucocorticoid GO:0051384 9.91 CASP3 IL10 TNF
14 interferon-gamma-mediated signaling pathway GO:0060333 9.91 ICAM1 IFNG IFNGR1
15 regulation of insulin secretion GO:0050796 9.91 IFNG IL1B TNF
16 neutrophil chemotaxis GO:0030593 9.91 CCL22 CXCL8 IFNG IL1B
17 cellular response to interferon-gamma GO:0071346 9.9 CCL22 ICAM1 IL12RB1
18 positive regulation of cell adhesion GO:0045785 9.89 CCR7 IFNG TNF
19 positive regulation of tumor necrosis factor production GO:0032760 9.88 IFNG NOD2 TLR4
20 regulation of cell adhesion GO:0030155 9.88 CXCL8 ICAM1 IL18
21 positive regulation of interleukin-6 production GO:0032755 9.88 IL1B NOD2 TLR4 TNF
22 cellular response to lipopolysaccharide GO:0071222 9.88 CXCL8 ICAM1 IFNG IL10 TLR4 TNF
23 extrinsic apoptotic signaling pathway GO:0097191 9.87 FASLG IFNG TNF
24 cellular response to organic substance GO:0071310 9.86 CASP3 ICAM1 IL1B
25 response to lipopolysaccharide GO:0032496 9.86 CASP3 CCR7 FASLG ICAM1 IL10 IL1B
26 positive regulation of phagocytosis GO:0050766 9.85 IL1B SLC11A1 TNF
27 positive regulation of JNK cascade GO:0046330 9.85 CCR7 IL1B NOD2 TLR4 TNF
28 negative regulation of interleukin-6 production GO:0032715 9.84 IL10 TLR4 TNF
29 lipopolysaccharide-mediated signaling pathway GO:0031663 9.84 IL18 IL1B TLR4 TNF
30 positive regulation of interleukin-12 production GO:0032735 9.83 CCR7 IFNG TLR4
31 positive regulation of interleukin-8 production GO:0032757 9.83 IL1B NOD2 TLR4 TNF
32 defense response to protozoan GO:0042832 9.82 IFNG IL10 SLC11A1
33 negative regulation of growth of symbiont in host GO:0044130 9.8 IFNG IL10 TNF
34 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.8 IFNG IL1B TNF
35 cellular response to organic cyclic compound GO:0071407 9.8 CASP3 IL18 IL1B NOD2 STAT3 TNF
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.78 IL10 IL1B TNF
37 positive regulation of NF-kappaB import into nucleus GO:0042346 9.78 IL18 IL1B TLR4 TNF
38 positive regulation of chemokine biosynthetic process GO:0045080 9.77 IFNG IL1B TNF
39 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 ICAM1 IFNG IL1B TLR4 TNF
40 positive regulation of MHC class II biosynthetic process GO:0045348 9.75 IFNG IL10 TLR4
41 T-helper 1 type immune response GO:0042088 9.74 IL18 TLR4
42 negative regulation of interleukin-17 production GO:0032700 9.74 IFNG TLR4
43 macrophage activation GO:0042116 9.74 SLC11A1 TLR4
44 positive regulation of T-helper 1 type immune response GO:0002827 9.74 IL12RB1 SLC11A1
45 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.74 IL18 IL1B
46 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.73 IFNG IL1B
47 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.73 TLR4 TNF
48 endothelial cell apoptotic process GO:0072577 9.73 IL10 TNF
49 regulation of defense response to virus by host GO:0050691 9.73 IFNG IL1B
50 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.73 CCR7 NOD2 SLC11A1

Molecular functions related to Lymphadenitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL22 CXCL8 FASLG IFNG IL10 IL18

Sources for Lymphadenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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