MCID: LYM021
MIFTS: 58

Lymphadenitis malady

Skin diseases, Immune diseases categories

Summaries for Lymphadenitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Lymphadenopathy refers to lymph nodes which are abnormal in size, number or consistency and is often... more...

MalaCards: Lymphadenitis, also known as chronic lymphadenitis, is related to pharyngitis and suppurative lymphadenitis. An important gene associated with Lymphadenitis is HSF4 (heat shock transcription factor 4), and among its related pathways are Regulation of IFNG signaling and LDL Oxidation in Atherogenesis. The compounds estrogen and dimethyl fumarate have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and breast, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Aliases & Classifications for Lymphadenitis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Immune diseases


Aliases & Descriptions:

lymphadenitis 8 10 60
chronic lymphadenitis 8 60
acute lymphadenitis 8 60
chronic lymphadenitis any lymph node, except mesenteric 8
inflammation of lymph node 8
lymphadenitis nos 8
chronic adenitis 8
acute adenitis 8
adenitis 8


Related Diseases for Lymphadenitis

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17GeneCards, 18GeneDecks
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Diseases related to Lymphadenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 285)
idRelated DiseaseScoreTop Affiliating Genes
1pharyngitis31.0HSF4
2suppurative lymphadenitis31.0HSF4, WEE1, FRG1
3tuberculosis30.9CXCL9, CXCR3, CD79A, CRP, IFNB1
4mediastinitis30.7CRP
5lupus erythematosus30.4CD79A
6thyroiditis30.3CD79A, FASLG
7systemic lupus erythematosus30.3IFNB1, ICAM1, PDCD1, FASLG, CRP, CD79A
8meningitis30.2CRP, CD79A
9vasculitis30.2CD79A, CRP, ICAM1
10leukemia30.2IFNB1, SOCS1, SOCS3, ICAM1, FASLG, SHC1
11herpes simplex30.1IFNB1, SOCS3, CD79A
12parotitis30.0HSF4
13pancreatitis30.0CRP, ICAM1
14tonsillitis30.0CD79A, CRP, HSF4
15connective tissue disease30.0ICAM1, CD79A
16breast cancer30.0IFNB1, SOCS1, SOCS3, SHC1, EBAG9, CXCR3
17glomerulonephritis30.0CXCL9, CD79A, ICAM1
18peritonitis29.9CRP
19dermatitis29.9ICAM1, CD79A, CXCR3, CXCL9
20pneumonia29.9HSF4, ICAM1, CRP, CD79A
21lung cancer29.9IFNB1, SOCS1, SOCS3, WEE1, EBAG9, CXCR3
22malaria29.8ICAM1, CXCL9
23proliferative glomerulonephritis29.8CD79A, CXCR3, CXCL9
24acute leukemia29.7SHC1
25ulcerative colitis29.7CRP
26melioidosis29.7CXCL9
27kawasaki disease29.7CRP
28erythema multiforme29.7ICAM1
29otitis media29.7CD79A
30prostatitis29.7CD79A
31adult-onset still's disease29.7CRP
32adenoma29.7EBAG9, SHC1
33encephalitis29.7CXCL9, CD68
34myeloid leukemia29.7SOCS1, SOCS3
35hepatitis29.7FASLG, IFNB1
36thrombocytopenia29.7CD79A
37obesity29.7CRP, SOCS3, SOCS1
38melanoma29.7IFNB1, SOCS1, SOCS3, ICAM1, PDCD1, FASLG
39cervicitis10.8
40mesenteric lymphadenitis10.8
41stomatitis10.7
42aphthous stomatitis10.7
43cat-scratch disease10.4
44appendicitis10.3
45tularemia10.3
46kikuchi disease10.3
47periodic fever, aphthous stomatitis, pharyngitis and adenitis10.3
48acute cervicitis10.2
49adult syndrome10.2
50chronic granulomatous disease10.1

Graphical network of the top 20 diseases related to Lymphadenitis:



Diseases related to lymphadenitis

Clinical Features for Lymphadenitis

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Drugs & Therapeutics for Lymphadenitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Lymphadenitis

Genetic Tests for Lymphadenitis

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Anatomical Context for Lymphadenitis

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32MalaCards
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MalaCards organs/tissues related to Lymphadenitis:

32
Lymph node, Testes, Breast, Skin, Thyroid, B cells, T cells, Lung, Tonsil, Eye, Whole blood, Liver, Spleen, Salivary gland, Prostate, Myeloid

Animal Models for Lymphadenitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lymphadenitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.4IFNB1, SOCS1, ICAM1, PDCD1, FASLG, SHC1
2MP:00053859.4SOCS3, ICAM1, PDCD1, FASLG, CRP, SHC1
3MP:00053848.9IFNB1, SOCS1, SOCS3, ICAM1, PDCD1, FASLG
4MP:00053978.9IFNB1, SOCS1, SOCS3, ICAM1, PDCD1, FASLG
5MP:00053768.7ICAM1, SOCS3, SOCS1, IFNB1, FASLG, CRP
6MP:00053878.5CXCL9, IFNB1, SOCS1, SOCS3, ICAM1, PDCD1

Publications for Lymphadenitis

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50PubMed
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Articles related to Lymphadenitis:

(show top 50)    (show all 653)
idTitleAuthorsYear
1
Granulomatous typhlocolitis, lymphangitis, and lymphadenitis in a horse infected with Listeria monocytogenes, Salmonella Typhimurium, and cyathostomes. (22688587)
2013
2
FDG PET/CT showing erythema nodosum associated with tuberculous lymphadenitis. (24152619)
2013
3
Rare association of cutaneous vasculitis, IgA nephropathy and antiphospholipid antibody syndrome with tuberculous lymphadenitis. (23917677)
2013
4
Diagnostic challenge in papillary thyroid carcinoma with cervical lymphadenopathy, metastasis, or tuberculous lymphadenitis. (24220443)
2013
5
IgG4-related autoimmune pancreatitis overlapping with Mikulicz's disease and lymphadenitis: A case report. (24409081)
2013
6
Cervical Lymphadenitis Caused by Group D Non-typhoidal Salmonella Associated with Concomitant Lymphoma. (24265973)
2013
7
Tuberculous cervical lymphadenitis masquerding as metastatis from papillary thyroid carcinoma. (23843822)
2012
8
Rapid culture diagnosis of tuberculous lymphadenitis from a tertiary care centre in an endemic nation: potential and pitfalls. (22885203)
2012
9
Epidemiological, bacteriological and molecular studies on caseous lymphadenitis in Sirohi goats of Rajasthan, India. (22371102)
2012
10
Extra-pulmonary primary multidrug-resistant tubercular lymphadenitis in an HIV negative patient. (22605844)
2012
11
Acute paradoxical reaction of cervical tuberculous lymphadenitis prompted by a misuse of etimicin sulphate. (22605866)
2012
12
Nerve dysfunction following surgical treatment of cervical non-tuberculous mycobacterial lymphadenitis in children. (20874782)
2011
13
A study of tubercular lymphadenitis: a comparison of various laboratory diagnostic modalities with a special reference to tubercular polymerase chain reaction. (22120800)
2011
14
Nodular sclerosing classical Hodgkin lymphoma masquerading as acute suppurative-necrotizing lymphadenitis. (21965120)
2011
15
Kikuchi-Fujimoto disease. Histiocytic necrotizing lymphadenitis. (22057597)
2011
16
Bacillus Calmette-Guerins vaccination at birth causing tuberculous granulomatous lymphadenitis. (22159392)
2011
17
Lymphadenitis as a Rare Side Effect of H1N1 Vaccine in a Child. (21209734)
2010
18
Severe thrombocytopenia secondary to tubercular lymphadenitis. (20522304)
2010
19
Deepgoing study on intrathoracic tuberculous lymphadenitis in adults using multidetector CT. (20529582)
2010
20
Infectious mononucleosis lymphoadenitis showing histologic findings indistinguishable from toxoplasma lymphadenitis. A report of three cases. (20181439)
2010
21
Identification and genotyping of the etiological agent of tuberculous lymphadenitis in Ethiopia. (19762953)
2009
22
Kikuchi-Fugimoto disease (Cervical Subacute Necrotising Lymphadenitis): an important benign disease often masquerading as lymphoma. (19568451)
2009
23
Tuberculous lymphadenitis. (20209720)
2009
24
Lymphadenitis in children is caused by Mycobacterium avium hominissuis and not related to 'bird tuberculosis'. (18320245)
2008
25
SOCS in situ expression in tuberculous lymphadenitis in an endemic area. (18538318)
2008
26
Species-specific immunocytochemical localization of Mycobacterium tuberculosis complex in fine needle aspirates of tuberculous lymphadenitis using antibody to 38 kDa immunodominant protein antigen. (18702359)
2008
27
A clinical study of histiocytic necrotizing lymphadenitis (Kikuchi's disease) in children. (18789543)
2008
28
Protracted cervical lymphadenitis with Mycobacterium avium and Methylobacterium mesophilicum. (17901817)
2007
29
Asteroid bodies in silicone lymphadenitis on fine-needle aspiration. (17924410)
2007
30
Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis): report of a case with other autoimmune manifestations. (17431451)
2007
31
Infiltrating ductal carcinoma of the breast, metastatic to axillary lymph nodes harboring primary tuberculous lymphadenitis. (16998601)
2006
32
Tuberculin skin testing is useful in the screening for nontuberculous mycobacterial cervicofacial lymphadenitis in children. (17109286)
2006
33
Immunohistochemical analysis of cytokines and apoptosis in tuberculous lymphadenitis. (16556259)
2006
34
Bacillus Calmette-Guerin (BCG) lymphadenitis-changing trends and management. (16599027)
2005
35
Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis). Case study and a literature review]. (15633936)
2004
36
A murine model of granulomatous colitis with mesenteric lymphadenitis induced by mycobacterial cord factor. (12596066)
2003
37
Cat scratch disease. A cause of regional lymphadenitis. (11681146)
2001
38
Hodgkin's disease mimicking suppurative lymphadenitis: a fine-needle aspiration report of five cases. (10319233)
1999
39
Cat scratch disease diagnosed by polymerase chain reaction in a patient with suspected tuberculous lymphadenitis. (10078182)
1999
40
Bacteremia and suppurative lymphadenitis due to Yersinia enterocolitica in a neutropenic patient who prepared chitterlings. (7578750)
1995
41
Chronic contagious ecthyma and caseous lymphadenitis in two Boer goats. (1287954)
1992
42
Pathologic quiz case 1. Granulomatous and suppurative lymphadenitis consistent with cat-scratch disease. (2297423)
1990
43
Granuloma inguinale of cervical lymph nodes simulating tuberculous lymphadenitis: two case reports and review of published reports. (3060425)
1988
44
Granulocytopenia in histiocytic necrotizing lymphadenitis without granulocytic infiltration: decreased CFU-C and an inhibitory effect of the serum. (4060977)
1985
45
Suppurative lymphadenitis with Yersinia enterocolitica. (4092702)
1985
46
Tuberculous mesenteric lymphadenitis in children. (6866788)
1983
47
Thyroid papillary adenoma in a guinea pig with signs of cervical lymphadenitis. (521385)
1979
48
Acute intussuception complicated by mesenteric lymphadenitis, suppurative otitis media, and subacute appendicitis; a case report. (14367994)
1955
49
Acute non-specific mesenteric lymphadenitis; incidence and prognosis in children. (14874429)
1951
50
Acute non-specific mesenteric lymphadenitis. (18117315)
1949

Genetic Variations for Lymphadenitis

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Expression for genes affiliated with Lymphadenitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphadenitis

Search GEO for disease gene expression data for Lymphadenitis.

Pathways for genes affiliated with Lymphadenitis

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53Reactome, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Lymphadenitis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2SOCS1, SOCS3
210.1CD68, ICAM1
3
Development Thrombopoetin signaling via JAK-STAT pathway
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10.1CRP, SOCS3, SOCS1
410.1SOCS1, SOCS3, SHC1
5
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10.1SOCS1, SOCS3, SHC1
6
Immune response IL-2 activation and signaling pathway
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10.1SHC1, SOCS3, SOCS1
7
Development EPO-induced Jak-STAT pathway
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10.1SHC1, SOCS3, SOCS1
810.1SHC1, SOCS3, SOCS1
9
Immune response IFN alpha/beta signaling pathway
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10.0IFNB1, SOCS1, SOCS3
1010.0SHC1, ICAM1, SOCS1
1110.0ICAM1, FASLG, SHC1
12
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9.9FASLG, ICAM1, SOCS3, IFNB1
13
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9.7IFNB1, SOCS1, SOCS3, ICAM1, SHC1
149.7CXCL9, ICAM1, SOCS3, SOCS1, IFNB1
15
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9.6IFNB1, SOCS1, SOCS3, FASLG, CXCR3, CXCL9
16
Hide members
9.5IFNB1, SOCS1, ICAM1, FASLG, SHC1, CD79A
17
Hide members
9.4IFNB1, SOCS1, SOCS3, ICAM1, PDCD1, SHC1

Compounds for genes affiliated with Lymphadenitis

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Lymphadenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CD79A
2dimethyl fumarate4410.6ICAM1, CXCR3
3ribavirin44 49 1112.6CXCR3, SOCS3
4cdp5714410.5ICAM1, CRP
5endotoxin4410.5ICAM1, FASLG, CXCR3
6edss4410.5IFNB1, CXCR3
7gamma globulin4410.5CRP
8bucillamine4410.5CD79A, CRP
9okt34410.4ICAM1, CRP, CD79A
10sulfasalazine44 28 49 1113.4CD79A, CRP, ICAM1
11groalpha4410.4ICAM1, CXCR3, CXCL9
12lactulose4410.4CRP, CD79A
13cycloheximide4410.4IFNB1, FASLG
14gadolinium4410.4CXCR3, IFNB1
15methacholine44 1111.4CD79A, CRP, ICAM1
16sodium cromoglycate4410.4ICAM1, CD79A
17dithranol4410.4ICAM1, FASLG
18allergens4410.3PDCD1, CD79A, CXCR3
19rituximab44 49 1112.3CD79A, CRP, FASLG
20il 104410.3IFNB1, CXCR3, CXCL9
21rantes4410.3IFNB1, ICAM1, FASLG, CXCR3
22ccl444 2811.3CXCL9, CXCR3, IFNB1
23ivig4410.3CD79A, CRP, FASLG, IFNB1
245-aza-2deoxycytidine4410.3IFNB1, SOCS1, SOCS3, FASLG
25neopterin4410.3CD79A, CRP, ICAM1, IFNB1
26tarc4410.2IFNB1, ICAM1, CXCR3, CXCL9
27ccl344 2811.2IFNB1, ICAM1, CXCR3, CXCL9
28bromodeoxyuridine4410.2IFNB1, SOCS3, FASLG, SHC1
29simvastatin44 49 59 28 11 2415.2IFNB1, ICAM1, FASLG, CRP
30cyclophosphamide44 49 1112.2CXCL9, CRP, FASLG, IFNB1
31dexamethasone44 49 28 1113.2CXCL9, CD79A, FASLG, IFNB1
32methotrexate44 49 1112.2IFNB1, FASLG, CRP, CD79A
33ascorbic acid44 2411.2ICAM1, FASLG, CRP, CD79A, LEPREL1
34n acetylcysteine4410.1ICAM1, FASLG, CRP, SHC1, CD79A
35pd 98,0594410.1IFNB1, ICAM1, FASLG, SHC1, CXCR3
36actinomycin d4410.1IFNB1, SOCS1, ICAM1, FASLG, SHC1
37heparin44 28 11 2413.1IFNB1, FASLG, CD79A, RIPK4, CXCR3
38ifn-alpha4410.0CXCL9, CXCR3, FASLG, SOCS3, SOCS1, IFNB1
39creatinine4410.0IFNB1, CRP, CD79A, CXCR3, CXCL9
40ly2940024410.0IFNB1, ICAM1, FASLG, CRP, SHC1, CXCR3
41sb 20358044 5911.0IFNB1, ICAM1, FASLG, CRP
42polyethylene glycol449.9ICAM1, CRP, CD79A
43glucose449.9SHC1, FASLG, SOCS3, SOCS1
44phosphatidylinositol449.9SOCS1, SOCS3, ICAM1, FASLG, SHC1, CXCR3
45nitric oxide44 11 2411.9SOCS1, SOCS3, ICAM1, FASLG, SHC1, CXCR3
46polysaccharide449.8CD79A, FASLG, ICAM1, IFNB1
47vegf449.6IFNB1, ICAM1, FASLG, CRP, SHC1, CD79A
48retinoic acid44 2410.6IFNB1, SOCS1, ICAM1, FASLG, SHC1, CD79A
49tyrosine449.4IFNB1, SOCS1, SOCS3, ICAM1, PDCD1, FASLG
50h2o2449.4IFNB1, ICAM1, FASLG, SHC1, CD79A

GO Terms for genes affiliated with Lymphadenitis

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16Gene Ontology
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Cellular components related to Lymphadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.6CXCL9, CXCR3, CD79A, FASLG, PDCD1, ICAM1

Biological processes related to Lymphadenitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of interferon-gamma-mediated signaling pathwayGO:06033410.2SOCS3, SOCS1
2regulation of type I interferon-mediated signaling pathwayGO:06033810.2SOCS3, SOCS1, IFNB1
3regulation of growthGO:04000810.2SHC1, SOCS3, SOCS1
4type I interferon-mediated signaling pathwayGO:06033710.0IFNB1, SOCS1, SOCS3
5interferon-gamma-mediated signaling pathwayGO:06033310.0SOCS1, SOCS3, ICAM1
6cytokine-mediated signaling pathwayGO:0192219.9IFNB1, SOCS1, SOCS3, ICAM1
7B cell proliferationGO:0421009.8CD79A, IFNB1

Molecular functions related to Lymphadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.2SHC1, SOCS1

Products for genes affiliated with Lymphadenitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphadenitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet