MCID: LYM021
MIFTS: 50

Lymphadenitis malady

Skin category

Summaries for Lymphadenitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Lymphadenopathy refers to lymph nodes which are abnormal in size, number or consistency and is often... more...

MalaCards: Lymphadenitis, also known as chronic lymphadenitis, is related to pharyngitis and suppurative lymphadenitis. An important gene associated with Lymphadenitis is HSF4 (heat shock transcription factor 4), and among its related pathways are Regulation of IFNG signaling and LDL Oxidation in Atherogenesis. The compounds estrogen and dimethyl fumarate have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and cardiovascular system.

Aliases & Classifications for Lymphadenitis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

lymphadenitis 8 10 61
chronic lymphadenitis 8 61
acute lymphadenitis 8 61
chronic lymphadenitis any lymph node, except mesenteric 8
inflammation of lymph node 8
lymphadenitis nos 8
chronic adenitis 8
acute adenitis 8
adenitis 8


Related Diseases for Lymphadenitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lymphadenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 272)
idRelated DiseaseScoreTop Affiliating Genes
1pharyngitis31.0HSF4
2suppurative lymphadenitis31.0HSF4, WEE1, FRG1
3tuberculosis30.9CXCR3, CD79A, CRP, CXCL9, IFNB1
4systemic lupus erythematosus30.3PDCD1, CD79A, ICAM1, CXCR3, IFNB1, CRP
5vasculitis30.3ICAM1, CD79A, CRP
6parotitis30.1HSF4
7thyroiditis30.1FASLG, CD79A
8tonsillitis30.0CRP, CD79A, HSF4
9proliferative glomerulonephritis29.8CD79A, CXCR3, CXCL9
10acute leukemia29.7SHC1
11ulcerative colitis29.7CRP
12melioidosis29.7CXCL9
13kawasaki disease29.7CRP
14erythema multiforme29.7ICAM1
15adult-onset still's disease29.7CRP
16adenoma29.7SHC1, EBAG9
17nephritis29.7CD79A, CXCR3
18thrombocytopenia29.7CD79A
19b-cell chronic lymphocytic leukemia29.7ICAM1, FASLG, CXCR3
20mesenteric lymphadenitis10.8
21stomatitis10.7
22aphthous stomatitis10.7
23kikuchi disease10.6
24appendicitis10.4
25tularemia10.4
26periodic fever, aphthous stomatitis, pharyngitis and adenitis10.3
27adult syndrome10.2
28chronic granulomatous disease10.1
29n syndrome10.1
30postauricular lymphadenitis10.1
31obstructive jaundice10.1
32papillary carcinoma10.1
33mixed connective tissue disease10.1
34aseptic meningitis10.1
35anthracosis10.1
36infectious mononucleosis10.1
37ecthyma10.1
38lymphogranuloma venereum10.1
39mycobacterium fortuitum10.1
40mycobacterium kansasii10.1
41mycobacterium malmoense10.1
42dysphagia10.1
43young syndrome10.0
44antiphospholipid syndrome10.0
45pulmonary tuberculosis10.0
46submandibular adenitis10.0
47hemophagocytic lymphohistiocytosis10.0
48cutaneous lupus erythematosus10.0
49cellulitis10.0
50o'nyong'nyong fever10.0

Graphical network of the top 20 diseases related to Lymphadenitis:



Diseases related to lymphadenitis

Clinical Features for Lymphadenitis

Drugs & Therapeutics for Lymphadenitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Lymphadenitis

Drug clinical trials:

Search ClinicalTrials for Lymphadenitis

Search NIH Clinical Center for Lymphadenitis

Search CenterWatch for Lymphadenitis

Genetic Tests for Lymphadenitis

Anatomical Context for Lymphadenitis

Animal Models for Lymphadenitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Lymphadenitis

Sources:
51PubMed
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Articles related to Lymphadenitis:

(show top 50)    (show all 653)
idTitleAuthorsYear
1
Comparison of Mycobacterium lentiflavum and Mycobacterium avium-intracellulare Complex Lymphadenitis. (24064561)
2014
2
Management of cervicofacial nontuberculous lymphadenitis in children. (24152916)
2013
3
Differential diagnosis of cervical lymphadenitis mimicking malignancy due to tularemia: our experiences. (24152503)
2013
4
Treatment assessment based on computerized lymph node volume and ratio of necrotic area in tuberculous cervical lymphadenitis. (21872412)
2012
5
Management of lymphadenitis due to non-tuberculous mycobacterial infection in children. (22438045)
2012
6
Evaluation of real-time polymerase chain reaction for detection of the 16S ribosomal RNA gene of Mycobacterium tuberculosis and the diagnosis of cervical tuberculous lymphadenitis in a country with a high tuberculosis incidence. (22523265)
2012
7
Disseminated cryptococcal lymphadenitis with negative latex agglutination test. (22882869)
2012
8
Petroleum jelly-induced penile paraffinoma with inguinal lymphadenitis mimicking incarcerated inguinal hernia. (23093564)
2012
9
Atlantoaxial rotatory fixation in a case of tubercular lymphadenitis. (23441501)
2012
10
Isolated porta hepatis lymphadenitis as a presenting feature of tuberculosis. (21841597)
2011
11
Tuberculous lymphadenitis and Horner's syndrome. (21920070)
2011
12
Breast carcinoma with co-existent microfilariasis and filarial lymphadenitis diagnosed on cytology. (21129098)
2011
13
Light-chain-restricted monocytoid B-cell cluster in reactive lymphadenitis associated with SjAPgren syndrome. (21417825)
2011
14
Nontuberculous mycobacterial cervicofacial lymphadenitis--a review and proposed classification system. (22014500)
2011
15
Immune hemolytic anemia in a patient with tuberculous lymphadenitis. (21572616)
2011
16
Kikuchi's lymphadenitis. (19526580)
2010
17
Mycobacterium avium complex cervical lymphadenitis in an immunocompetent adult. (20668140)
2010
18
Primary tuberculous lymphadenitis: A case report. (23662079)
2010
19
Mediastinal tuberculous lymphadenitis with intractable fistula to the neck. (20333580)
2010
20
Necrotizing lymphadenitis: Kikuchi--Fujimoto disease alias lupus lymphadenitis? (19933723)
2010
21
Mycobacterium bovis BCG-itis and cervical lymphadenitis due to Salmonella enteritidis in a patient with complete interleukin-12/-23 receptor beta1 deficiency. (20213287)
2010
22
Cervical tuberculous lymphadenitis in the elderly: comparative diagnostic findings. (19958562)
2009
23
Fine needle aspiration cytology in childhood TB lymphadenitis. (19936644)
2009
24
Suppurative iliac lymphadenitis masquerading as appendicitis in an HIV-infected patient. (19451334)
2009
25
Necrotizing lymphadenitis of the neck. (19456001)
2009
26
Appendicitis, mesenteric lymphadenitis, and subsequent risk of ulcerative colitis: cohort studies in Sweden and Denmark. (19273506)
2009
27
Polymerase chain reaction for pathogen identification in persistent pediatric cervical lymphadenitis. (19289701)
2009
28
Complication after subacute cervical lymphadenitis]. (19618128)
2009
29
Localized leishmanial lymphadenitis: an unusual manifestation of the disease in an immunocompetent patient. (19614777)
2009
30
Light-chain-restricted germinal centres in reactive lymphadenitis: report of eight cases. (18315596)
2008
31
Diagnosis of tuberculous lymphadenitis: combining cytomorphology, microbiology and molecular techniques - a study from Sri Lanka. (18603679)
2008
32
Deep venous thrombosis associated with antiphospholipid antibodies following tuberculosis lymphadenitis in a predisposed patient. (18600102)
2008
33
Detection of Mycobacterium tuberculosis by polymerase chain reaction with DNA eluted from aspirate smears of tuberculous lymphadenitis. (18382361)
2008
34
The need to reassess the value of fine needle aspiration in the diagnosis of tuberculous cervical lymphadenitis in Iran. (17654360)
2007
35
Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of peripancreatic tuberculous lymphadenitis. (17322998)
2007
36
Cryptococcal lymphadenitis diagnosed by fine-needle aspiration biopsy. (17230573)
2007
37
A case of dermatopathic lymphadenitis diagnosed by fine needle aspiration. (17008294)
2006
38
Corynebacterium pseudotuberculosis necrotizing lymphadenitis in a twelve-year-old patient. (16940849)
2006
39
Fine-needle aspiration cytology in tuberculous lymphadenitis of patients with and without HIV infection. (15452909)
2004
40
Kikuchi-Fujimoto's necrotizing lymphadenitis in association with discoid lupus erthematosus: a case report. (15988552)
2004
41
Extensive inguinal lymphadenitis. Ecthyma with inguinal lymphadenitis. (8678580)
1996
42
Vulval elephantiasis : A sequel to tubercular lymphadenitis. (20953000)
1995
43
Demonstration of Chlamydia trachomatis in inguinal lymphadenitis of lymphogranuloma venereum: a light microscopy, electron microscopy and polymerase chain reaction study. (8751333)
1995
44
Mesenteric lymphadenitis or appendicitis? (7618596)
1995
45
Pasteurella multocida infection complicating nontuberculous mycobacterial lymphadenitis. (7746704)
1995
46
Generalized suppurative lymphadenitis with typhoidal salmonellosis. (3211632)
1988
47
Tuberculous mesenteric lymphadenitis clinically presenting as abdominal mass: CT and sonographic findings. (3932482)
1985
48
Brucella suis: an unusual cause of suppurative lymphadenitis in an outpatient. (7130371)
1982
49
Suppurative mesenteric lymphadenitis in children. Case reports. (6457399)
1981
50
Suppurative lymphadenitis in childhood. (4191446)
1970

Genetic Variations for Lymphadenitis

Expression for genes affiliated with Lymphadenitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphadenitis

Search GEO for disease gene expression data for Lymphadenitis.

Pathways for genes affiliated with Lymphadenitis

Sources:
54Reactome, 52QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Lymphadenitis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2SOCS1, SOCS3
210.1CD68, ICAM1
3
Development Thrombopoetin signaling via JAK-STAT pathway
Hide members
10.1CRP, SOCS3, SOCS1
410.1SOCS1, SOCS3, SHC1
5
Hide members
10.1SOCS1, SOCS3, SHC1
6
Immune response IL-2 activation and signaling pathway
Hide members
10.1SHC1, SOCS3, SOCS1
7
Development EPO-induced Jak-STAT pathway
Hide members
10.1SHC1, SOCS3, SOCS1
810.1SHC1, SOCS3, SOCS1
9
Immune response IFN alpha/beta signaling pathway
Hide members
10.0IFNB1, SOCS1, SOCS3
1010.0SHC1, ICAM1, SOCS1
1110.0ICAM1, FASLG, SHC1
12
Hide members
9.9FASLG, ICAM1, SOCS3, IFNB1
13
Hide members
9.7IFNB1, SOCS1, SOCS3, ICAM1, SHC1
149.7CXCL9, ICAM1, SOCS3, SOCS1, IFNB1
15
Hide members
9.6IFNB1, SOCS1, SOCS3, FASLG, CXCR3, CXCL9
16
Hide members
9.5IFNB1, SOCS1, ICAM1, FASLG, SHC1, CD79A
17
Hide members
9.4IFNB1, SOCS1, SOCS3, ICAM1, PDCD1, SHC1

Compounds for genes affiliated with Lymphadenitis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB
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Compounds related to Lymphadenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7CD79A
2dimethyl fumarate4510.6ICAM1, CXCR3
3ribavirin45 50 1112.6CXCR3, SOCS3
4cdp5714510.5ICAM1, CRP
5endotoxin4510.5ICAM1, FASLG, CXCR3
6edss4510.5IFNB1, CXCR3
7gamma globulin4510.5CRP
8bucillamine4510.5CD79A, CRP
9okt34510.4ICAM1, CRP, CD79A
10sulfasalazine45 29 50 1113.4CD79A, CRP, ICAM1
11groalpha4510.4ICAM1, CXCR3, CXCL9
12lactulose4510.4CRP, CD79A
13cycloheximide4510.4IFNB1, FASLG
14gadolinium4510.4CXCR3, IFNB1
15methacholine45 1111.4CD79A, CRP, ICAM1
16sodium cromoglycate4510.4ICAM1, CD79A
17dithranol4510.4ICAM1, FASLG
18allergens4510.3PDCD1, CD79A, CXCR3
19rituximab45 50 1112.3CD79A, CRP, FASLG
20il 104510.3IFNB1, CXCR3, CXCL9
21rantes4510.3IFNB1, ICAM1, FASLG, CXCR3
22ccl445 2911.3CXCL9, CXCR3, IFNB1
23ivig4510.3CD79A, CRP, FASLG, IFNB1
245-aza-2deoxycytidine4510.3IFNB1, SOCS1, SOCS3, FASLG
25neopterin4510.3CD79A, CRP, ICAM1, IFNB1
26tarc4510.2IFNB1, ICAM1, CXCR3, CXCL9
27ccl345 2911.2IFNB1, ICAM1, CXCR3, CXCL9
28bromodeoxyuridine4510.2IFNB1, SOCS3, FASLG, SHC1
29simvastatin45 50 60 29 11 2415.2IFNB1, ICAM1, FASLG, CRP
30cyclophosphamide45 50 1112.2CXCL9, CRP, FASLG, IFNB1
31dexamethasone45 50 29 1113.2CXCL9, CD79A, FASLG, IFNB1
32methotrexate45 50 1112.2IFNB1, FASLG, CRP, CD79A
33ascorbic acid45 2411.2ICAM1, FASLG, CRP, CD79A, LEPREL1
34n acetylcysteine4510.1ICAM1, FASLG, CRP, SHC1, CD79A
35pd 98,0594510.1IFNB1, ICAM1, FASLG, SHC1, CXCR3
36actinomycin d4510.1IFNB1, SOCS1, ICAM1, FASLG, SHC1
37heparin45 29 11 2413.1IFNB1, FASLG, CD79A, RIPK4, CXCR3
38ifn-alpha4510.0CXCL9, CXCR3, FASLG, SOCS3, SOCS1, IFNB1
39creatinine4510.0IFNB1, CRP, CD79A, CXCR3, CXCL9
40ly2940024510.0IFNB1, ICAM1, FASLG, CRP, SHC1, CXCR3
41sb 20358045 6011.0IFNB1, ICAM1, FASLG, CRP
42polyethylene glycol459.9ICAM1, CRP, CD79A
43glucose459.9SHC1, FASLG, SOCS3, SOCS1
44phosphatidylinositol459.9SOCS1, SOCS3, ICAM1, FASLG, SHC1, CXCR3
45nitric oxide45 11 2411.9SOCS1, SOCS3, ICAM1, FASLG, SHC1, CXCR3
46polysaccharide459.8CD79A, FASLG, ICAM1, IFNB1
47vegf459.6IFNB1, ICAM1, FASLG, CRP, SHC1, CD79A
48retinoic acid45 2410.6IFNB1, SOCS1, ICAM1, FASLG, SHC1, CD79A
49tyrosine459.4IFNB1, SOCS1, SOCS3, ICAM1, PDCD1, FASLG
50h2o2459.4IFNB1, ICAM1, FASLG, SHC1, CD79A

GO Terms for genes affiliated with Lymphadenitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Lymphadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.6CXCL9, CXCR3, CD79A, FASLG, PDCD1, ICAM1

Biological processes related to Lymphadenitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of interferon-gamma-mediated signaling pathwayGO:06033410.2SOCS3, SOCS1
2regulation of type I interferon-mediated signaling pathwayGO:06033810.2IFNB1, SOCS1, SOCS3
3regulation of growthGO:04000810.2SHC1, SOCS3, SOCS1
4interferon-gamma-mediated signaling pathwayGO:06033310.1SOCS3, ICAM1, SOCS1
5cytokine-mediated signaling pathwayGO:0192219.9ICAM1, SOCS3, IFNB1, SOCS1
6type I interferon-mediated signaling pathwayGO:0603379.9IFNB1, SOCS3, SOCS1
7B cell proliferationGO:0421009.8CD79A, IFNB1

Molecular functions related to Lymphadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.2SHC1, SOCS1

Products for genes affiliated with Lymphadenitis

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  • Lysates
  • Antibodies

Sources for Lymphadenitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet