MCID: LYM035
MIFTS: 28

Lymphangiectasis malady

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Lymphangiectasis

Aliases & Descriptions for Lymphangiectasis:

Name: Lymphangiectasis 50 69
Lymphangiectasia 50

Classifications:



Summaries for Lymphangiectasis

MalaCards based summary : Lymphangiectasis, also known as lymphangiectasia, is related to hennekam lymphangiectasia-lymphedema syndrome 2 and hennekam lymphangiectasia-lymphedema syndrome 1. An important gene associated with Lymphangiectasis is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Striated Muscle Contraction. The drugs Miconazole and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and testes.

Wikipedia : 71 Lymphangiectasia is a pathologic dilation of lymph vessels. When it occurs in the intestines of dogs,... more...

Related Diseases for Lymphangiectasis

Diseases related to Lymphangiectasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
id Related Disease Score Top Affiliating Genes
1 hennekam lymphangiectasia-lymphedema syndrome 2 12.2
2 hennekam lymphangiectasia-lymphedema syndrome 1 10.7
3 lymphangiectasia, pulmonary, congenital 10.7
4 mullerian derivatives, persistence of, with lymphangiectasia and postaxial polydactyly 10.7
5 lymphangiectasia, intestinal 10.7
6 hennekam syndrome 10.7
7 primary intestinal lymphangiectasia 10.7
8 13q12.3 microdeletion syndrome 10.0 ACTC1 VIM
9 lymphomatoid papulosis 10.0 ACTC1 VIM
10 chest wall parachordoma 10.0 ACTC1 VIM
11 isolated anterior cervical hypertrichosis 10.0 ACTC1 VIM
12 osteomyelitis 10.0 ACTC1 VIM
13 myoma 10.0 ACTC1 VIM
14 congenital myasthenic syndrome 10.0 ACTC1 VIM
15 spleen angiosarcoma 10.0 ACTC1 VIM
16 malignant dermis tumor 10.0 ACTC1 VIM
17 urethral cancer 10.0 ACTC1 VIM
18 conjunctival cancer 10.0 ACTC1 VIM
19 biemond syndrome 10.0 ACTC1 VIM
20 intestinal obstruction 10.0 ACTC1 VIM
21 testicular granulosa cell tumor 10.0 ACTC1 VIM
22 male urethral cancer 10.0 ACTC1 VIM
23 lymphangiosarcoma 10.0 ACTC1 VIM
24 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.0 ACTC1 VIM
25 mediastinum liposarcoma 10.0 ACTC1 VIM
26 coronary stenosis 10.0 ACTC1 VIM
27 dyslexia 10.0 ACTC1 VIM
28 sebaceous adenoma 10.0 ACTC1 VIM
29 cauda equina intradural extramedullary astrocytoma 10.0 ACTC1 VIM
30 glomangioma 10.0 ACTC1 VIM
31 omodysplasia 2 10.0 ACTC1 VIM
32 t-cell childhood lymphoblastic lymphoma 10.0 ACTC1 VIM
33 growth retardation hydrocephaly lung hypoplasia 10.0 ACTC1 VIM
34 pilar sheath acanthoma 10.0 ACTC1 VIM
35 lung benign neoplasm 10.0 ACTC1 VIM
36 fitz-hugh-curtis syndrome 10.0 ACTC1 VIM
37 diarrhea, chronic, with villous atrophy 10.0 ACTC1 VIM
38 desmoid tumor 10.0 ACTC1 VIM
39 orthostatic proteinuria 10.0 ACTC1 VIM
40 popliteal pterygium syndrome, bartsocas-papas type 10.0 ACTC1 VIM
41 scirrhous adenocarcinoma 10.0 ACTC1 VIM
42 lymphangioma 9.9
43 hyperpituitarism 9.9 ACTC1 VIM
44 caroli disease 9.9 ACTC1 VIM
45 juvenile xanthogranuloma 9.9 ACTC1 VIM
46 diabetes persistent mullerian ducts 9.9 ACTC1 VIM
47 neutrophil immunodeficiency syndrome 9.9 ACTC1 VIM
48 preretinal fibrosis 9.9 ACTC1 VIM
49 mediastinum angiosarcoma 9.9 ACTC1 VIM
50 cecum adenoma 9.9 ACTC1 VIM

Graphical network of the top 20 diseases related to Lymphangiectasis:



Diseases related to Lymphangiectasis

Symptoms & Phenotypes for Lymphangiectasis

Drugs & Therapeutics for Lymphangiectasis

Drugs for Lymphangiectasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
4 Anti-Bacterial Agents Phase 2
5 Anti-Infective Agents Phase 2
6 Immunosuppressive Agents Phase 2
7 Antifungal Agents Phase 2
8 Antibiotics, Antitubercular Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2
2 Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders Recruiting NCT02156115
3 International Lymphatic Disease and Lymphedema Registry Recruiting NCT01336790

Search NIH Clinical Center for Lymphangiectasis

Genetic Tests for Lymphangiectasis

Anatomical Context for Lymphangiectasis

MalaCards organs/tissues related to Lymphangiectasis:

39
Breast, Lung, Testes, Heart, Endothelial, Kidney, Spleen

Publications for Lymphangiectasis

Articles related to Lymphangiectasis:

(show top 50) (show all 119)
id Title Authors Year
1
Acquired lymphangiectasis following surgery and radiotherapy of breast cancer. ( 25657438 )
2015
2
Severe primary pulmonary lymphangiectasis in a premature infant: management and follow up to early childhood. ( 25711257 )
2015
3
Reply to scurry et Al.: vulvar lymphangiectasis, an indicator of lymph stasis, is an authentic sign of abnormal histopathology in labiaplasty specimens. ( 25811280 )
2015
4
Congenital pulmonary lymphangiectasis. ( 24997116 )
2014
5
A case of transient lymphangiectasis of the penis. ( 24846179 )
2014
6
Mildly progressive pulmonary lymphangiectasis diagnosed in a young adult. ( 24684358 )
2014
7
Removal of lymphangiectasis using high-frequency radio wave electrosurgery. ( 22968357 )
2013
8
Firm cord-like band over the penile shaft. Benign transient lymphangiectasis of the penis. ( 22182374 )
2012
9
Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage. ( 22328411 )
2012
10
Osteomalacia and osteoporosis associated with primary intestinal lymphangiectasis. ( 22800909 )
2012
11
Conjunctival Lymphangiectasis. ( 20429497 )
2010
12
Congenital pulmonary lymphangiectasis: report of an autopsy case masquerading as pulmonary interstitial emphysema. ( 20399027 )
2010
13
Lymphangiectasis of lower limb: A rare challenging case. ( 20368868 )
2009
14
Combination technique of radiofrequency ablation with sclerotherapy in acquired lymphangiectasis of the vulva. ( 20300370 )
2009
15
Outcome of children with pulmonary lymphangiectasis. ( 19330773 )
2009
16
In-transit metastasis from melanoma presenting as lymphangiectasis: a case report. ( 19842575 )
2009
17
Congenital pulmonary lymphangiectasis. ( 19172338 )
2009
18
Lymphangiectasis of lower limb. ( 20368869 )
2009
19
The Multi-Detector CT findings of giant abdominal lymphangiectasis mimicking a mesenteric cystic mass in a patient with midgut volvulus. ( 25610038 )
2008
20
Osteomalacia in a patient with primary intestinal lymphangiectasis (Waldmann's disease). ( 17900962 )
2008
21
Clinico-pathological characteristics of congenital pulmonary lymphangiectasis: report of two cases. ( 17728521 )
2007
22
An adult with a cord round the neck: benign transient lymphangiectasis of the penis. ( 17921623 )
2007
23
Pulmonary lymphangiectasis in an asymptomatic adult. ( 16179818 )
2006
24
Congenital pulmonary lymphangiectasis sequence: a rare, heterogeneous, and lethal etiology for prenatal pleural effusion. ( 16941717 )
2006
25
Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis. ( 16772393 )
2006
26
Unilobar congenital pulmonary lymphangiectasis mimicking congenital lobar emphysema: an underestimated presentation? ( 15136998 )
2004
27
Acquired lymphangiectasis after breast conservation treatment for breast cancer: report of a case. ( 15347491 )
2004
28
Autopsy case of congenital pulmonary lymphangiectasis. ( 15189509 )
2004
29
Surgical management of conjunctival lymphangiectasis by conjunctival resection. ( 14516817 )
2003
30
Primary pulmonary lymphangiectasis in a premature infant: resolution following intensive care. ( 12687599 )
2003
31
Congenital pulmonary lymphangiectasis. ( 14686556 )
2003
32
Thoracic lymphangiectasis presenting with chyloptysis and bronchial cast expectoration. ( 12522631 )
2002
33
Chylous reflux into localized pulmonary lymphangiectasis. ( 12173851 )
2002
34
Persistence of MA1llerian derivatives and intestinal lymphangiectasis in two newborn brothers: confirmation of the Urioste syndrome. ( 11746031 )
2001
35
A case of cutaneous lymphangiectasis secondary to breast cancer treatment. ( 11903671 )
2001
36
Lymphangiectasis with iniencephaly. ( 11844186 )
2001
37
Thoracic lymphangiomas, lymphangiectasis, lymphangiomatosis, and lymphatic dysplasia syndrome. ( 10712360 )
2000
38
Congenital unilobar pulmonary lymphangiectasis. ( 10230931 )
1999
39
Acquired lymphangiectasis. ( 9932832 )
1999
40
Treatment of acquired cutaneous lymphangiectasis of the thigh and vulva with a carbon dioxide laser. ( 10430005 )
1999
41
Lymphangioma and congenital pulmonary lymphangiectasis: a histologic, immunohistochemical, and clinicopathologic comparison. ( 10392631 )
1999
42
Cutaneous lymphangiectasis: treatment with sclerotherapy. ( 9462778 )
1998
43
Acquired lymphangiectasis following mastectomy and radiation therapy--report of a case and review of the literature. ( 8894426 )
1996
44
Benign transient lymphangiectasis. ( 8854157 )
1996
45
Progressive lymphangiectasis and recurrent chylothorax in a dog after thoracic duct ligation. ( 7559046 )
1995
46
Unilateral lymphangiectasis of the kidney: an unusual cause of renal enlargement in an infant. ( 7815616 )
1995
47
Congenital pulmonary lymphangiectasis presenting as a unilateral hyperlucent lung. ( 8181508 )
1994
48
Pancreatic lymphangiectasis. ( 7942757 )
1994
49
Persistence of mA1llerian derivatives, lymphangiectasis, hepatic failure, postaxial polydactyly, renal and craniofacial anomalies. ( 8256813 )
1993
50
Congenital pulmonary lymphangiectasis with chylothorax: a heterogeneous lymphatic vessel abnormality. ( 8368253 )
1993

Variations for Lymphangiectasis

Expression for Lymphangiectasis

Search GEO for disease gene expression data for Lymphangiectasis.

Pathways for Lymphangiectasis

Pathways related to Lymphangiectasis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.44 ACTC1 VIM
2 10.48 ACTC1 VIM

GO Terms for Lymphangiectasis

Cellular components related to Lymphangiectasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 8.62 ACTC1 VIM

Biological processes related to Lymphangiectasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 8.96 ACTC1 VIM
2 muscle filament sliding GO:0030049 8.62 ACTC1 VIM

Sources for Lymphangiectasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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