MCID: LYM035
MIFTS: 28

Lymphangiectasis malady

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Lymphangiectasis

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Aliases & Descriptions for Lymphangiectasis:

Name: Lymphangiectasis 48 68
 
Lymphangiectasia 48

Classifications:



Summaries for Lymphangiectasis

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Wikipedia:71 Lymphangiectasia is a pathologic dilation of lymph vessels. When it occurs in the intestines of dogs,... more...

MalaCards based summary: Lymphangiectasis, also known as lymphangiectasia, is related to hennekam lymphangiectasia-lymphedema syndrome 2 and hennekam lymphangiectasia-lymphedema syndrome 1. An important gene associated with Lymphangiectasis is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways are Cytoskeletal Signaling and Striated Muscle Contraction. Affiliated tissues include breast, lung and endothelial.

Related Diseases for Lymphangiectasis

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Diseases related to Lymphangiectasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1hennekam lymphangiectasia-lymphedema syndrome 212.2
2hennekam lymphangiectasia-lymphedema syndrome 110.7
3lymphangiectasia, pulmonary, congenital10.7
4mullerian derivatives, persistence of, with lymphangiectasia and postaxial polydactyly10.7
5lymphangiectasia, intestinal10.7
6hennekam syndrome10.7
7primary intestinal lymphangiectasia10.7
813q12.3 microdeletion syndrome10.0ACTC1, VIM
9lymphomatoid papulosis10.0ACTC1, VIM
10chest wall parachordoma10.0ACTC1, VIM
11isolated anterior cervical hypertrichosis10.0ACTC1, VIM
12osteomyelitis10.0ACTC1, VIM
13myoma10.0ACTC1, VIM
14congenital myasthenic syndrome10.0ACTC1, VIM
15spleen angiosarcoma10.0ACTC1, VIM
16malignant dermis tumor10.0ACTC1, VIM
17urethral cancer10.0ACTC1, VIM
18conjunctival cancer10.0ACTC1, VIM
19biemond syndrome10.0ACTC1, VIM
20intestinal obstruction10.0ACTC1, VIM
21testicular granulosa cell tumor10.0ACTC1, VIM
22male urethral cancer10.0ACTC1, VIM
23lymphangiosarcoma10.0ACTC1, VIM
24hypogonadotropic hypogonadism-retinitis pigmentosa syndrome10.0ACTC1, VIM
25mediastinum liposarcoma10.0ACTC1, VIM
26coronary stenosis10.0ACTC1, VIM
27dyslexia10.0ACTC1, VIM
28sebaceous adenoma10.0ACTC1, VIM
29cauda equina intradural extramedullary astrocytoma10.0ACTC1, VIM
30glomangioma10.0ACTC1, VIM
31omodysplasia 210.0ACTC1, VIM
32t-cell childhood lymphoblastic lymphoma10.0ACTC1, VIM
33growth retardation hydrocephaly lung hypoplasia10.0ACTC1, VIM
34pilar sheath acanthoma10.0ACTC1, VIM
35lung benign neoplasm10.0ACTC1, VIM
36fitz-hugh-curtis syndrome10.0ACTC1, VIM
37diarrhea, chronic, with villous atrophy10.0ACTC1, VIM
38desmoid tumor10.0ACTC1, VIM
39orthostatic proteinuria10.0ACTC1, VIM
40popliteal pterygium syndrome, bartsocas-papas type10.0ACTC1, VIM
41scirrhous adenocarcinoma10.0ACTC1, VIM
42lymphangioma9.9
43hyperpituitarism9.9ACTC1, VIM
44caroli disease9.9ACTC1, VIM
45juvenile xanthogranuloma9.9ACTC1, VIM
46diabetes persistent mullerian ducts9.9ACTC1, VIM
47neutrophil immunodeficiency syndrome9.9ACTC1, VIM
48preretinal fibrosis9.9ACTC1, VIM
49mediastinum angiosarcoma9.9ACTC1, VIM
50cecum adenoma9.9ACTC1, VIM

Graphical network of the top 20 diseases related to Lymphangiectasis:



Diseases related to lymphangiectasis

Symptoms & Phenotypes for Lymphangiectasis

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Drugs & Therapeutics for Lymphangiectasis

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Drugs for Lymphangiectasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Miconazoleapproved, investigational, vet_approvedPhase 2370622916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
2
Sirolimusapproved, investigationalPhase 2194053123-88-95284616, 6436030, 46835353
Synonyms:
(-)-Rapamycin
(-)-rapamycin
1fkb
1pbk
23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine
23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29
3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
53123-88-9
A422989, NSC226080
AC-722
AC1L1JH9
AC1L7MJ9
AC1L9ZMV
AY 22989
AY-22989
AY22989
Ambotz53123-88-9
Antibiotic AY 22989
BIDD:PXR0165
Bio1_000293
Bio1_000782
Bio1_001271
Bio2_000375
Bio2_000855
BiomolKI2_000084
C07909
C51H79NO13
CBiol_002007
CCRIS 9024
CHEBI:100923
CHEBI:9168
CHEMBL413
CID10213190
CID10795871
CID11949238
CID11959112
CID313006
CID478951
CID5040
CID5284616
CID5358081
CID5374464
CID5460439
CID5497196
CID5924240
CID6436030
CID6610270
CID6610346
CID6711160
CID6713081
CID9833581
CID9854379
CID9854380
CID9962926
CID9962928
D00753
DB00877
DE-109
DivK1c_006936
 
FT-0082351
HMS2089A21
HSDB 7284
KBio1_001880
KBio2_000410
KBio2_002978
KBio2_005546
KBio3_000779
KBio3_000780
KBioGR_000410
KBioSS_000410
LCP-Siro
LMPK06000003
LS-143290
MLS000028373
MS-R001
MolMap_000043
MolPort-003-959-433
NCGC00021305-05
NCI60_001851
NCIMech_000355
NSC 226080
NSC226080
Perceiva
QTL1_000069
R0395_SIAL
R0395_SIGMA
RAP
RAPA
RPM
Rapammune
Rapamune
Rapamune (TN)
Rapamycin
Rapamycin (TN)
Rapamycin C-7, analog 4
Rapamycin Immunosuppressant Drug
Rapamycin from Streptomyces hygroscopicus
S1039_Selleck
SIIA 9268A
SILA 9268A
SILA9268A
SMP1_000255
SMR000058564
Sirolimus
Sirolimus (RAPAMUNE)
Sirolimus (USAN/INN)
Sirolimus [USAN:BAN:INN]
Sirolimus, Rapamune,Rapamycin
SpecPlus_000840
UNII-W36ZG6FT64
UNM-0000358684
WY-090217
Wy 090217
heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy
nchembio.100-comp4
nchembio.2007.42-comp2
nchembio.79-comp1
nchembio762-comp1
nchembio883-comp3
rapamycin
sirolimus
3
EverolimusapprovedPhase 21940159351-69-66442177
Synonyms:
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
(1R,9S,12S,15R,16E,23S,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriacont
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34as)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethy
07741_FLUKA
159351-69-6
40-O-(2-hydroxyethyl)-rapamycin
42-O-(2-Hydroxyethyl)rapamycin
Afinitor
CERTICAN(R)
CHEMBL1201755
Certican
D02714
DB01590
 
Everolimus
Everolimus (JAN/USAN/INN)
Everolimus [USAN]
LS-143292
MolPort-003-847-342
MolPort-003-925-588
NCGC00167512-01
NVP-RAD-001
RAD 001
RAD-001
RAD-001C
RAD001
RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus
S1120_Selleck
SDZ-RAD
UNII-9HW64Q8G6G
Zortress
everolimus
4Immunosuppressive AgentsPhase 213086
5Anti-Infective AgentsPhase 222062
6Antibiotics, AntitubercularPhase 27180
7Antifungal AgentsPhase 23696
8Anti-Bacterial AgentsPhase 211226

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety and Efficacy Study of Sirolimus in Complicated Vascular AnomaliesActive, not recruitingNCT00975819Phase 2
2Characterization of the Pathogenesis of Primary and Secondary Lymphatic DisordersRecruitingNCT02156115
3International Lymphatic Disease and Lymphedema RegistryRecruitingNCT01336790

Search NIH Clinical Center for Lymphangiectasis

Genetic Tests for Lymphangiectasis

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Anatomical Context for Lymphangiectasis

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MalaCards organs/tissues related to Lymphangiectasis:

36
Breast, Lung, Endothelial, Testes, Kidney, Spleen, Heart

Publications for Lymphangiectasis

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Articles related to Lymphangiectasis:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
Acquired lymphangiectasis following surgery and radiotherapy of breast cancer. (25657438)
2015
2
Severe primary pulmonary lymphangiectasis in a premature infant: management and follow up to early childhood. (25711257)
2015
3
Reply to scurry et Al.: vulvar lymphangiectasis, an indicator of lymph stasis, is an authentic sign of abnormal histopathology in labiaplasty specimens. (25811280)
2015
4
Congenital pulmonary lymphangiectasis. (24997116)
2014
5
A case of transient lymphangiectasis of the penis. (24846179)
2014
6
Mildly progressive pulmonary lymphangiectasis diagnosed in a young adult. (24684358)
2014
7
Removal of lymphangiectasis using high-frequency radio wave electrosurgery. (22968357)
2013
8
Firm cord-like band over the penile shaft. Benign transient lymphangiectasis of the penis. (22182374)
2012
9
Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage. (22328411)
2012
10
Osteomalacia and osteoporosis associated with primary intestinal lymphangiectasis. (22800909)
2012
11
Conjunctival Lymphangiectasis. (20429497)
2010
12
Congenital pulmonary lymphangiectasis: report of an autopsy case masquerading as pulmonary interstitial emphysema. (20399027)
2010
13
Lymphangiectasis of lower limb: A rare challenging case. (20368868)
2009
14
Combination technique of radiofrequency ablation with sclerotherapy in acquired lymphangiectasis of the vulva. (20300370)
2009
15
Outcome of children with pulmonary lymphangiectasis. (19330773)
2009
16
In-transit metastasis from melanoma presenting as lymphangiectasis: a case report. (19842575)
2009
17
Congenital pulmonary lymphangiectasis. (19172338)
2009
18
Lymphangiectasis of lower limb. (20368869)
2009
19
The Multi-Detector CT findings of giant abdominal lymphangiectasis mimicking a mesenteric cystic mass in a patient with midgut volvulus. (25610038)
2008
20
Osteomalacia in a patient with primary intestinal lymphangiectasis (Waldmann's disease). (17900962)
2008
21
Clinico-pathological characteristics of congenital pulmonary lymphangiectasis: report of two cases. (17728521)
2007
22
An adult with a cord round the neck: benign transient lymphangiectasis of the penis. (17921623)
2007
23
Pulmonary lymphangiectasis in an asymptomatic adult. (16179818)
2006
24
Congenital pulmonary lymphangiectasis sequence: a rare, heterogeneous, and lethal etiology for prenatal pleural effusion. (16941717)
2006
25
Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis. (16772393)
2006
26
Unilobar congenital pulmonary lymphangiectasis mimicking congenital lobar emphysema: an underestimated presentation? (15136998)
2004
27
Acquired lymphangiectasis after breast conservation treatment for breast cancer: report of a case. (15347491)
2004
28
Autopsy case of congenital pulmonary lymphangiectasis. (15189509)
2004
29
Surgical management of conjunctival lymphangiectasis by conjunctival resection. (14516817)
2003
30
Primary pulmonary lymphangiectasis in a premature infant: resolution following intensive care. (12687599)
2003
31
Congenital pulmonary lymphangiectasis. (14686556)
2003
32
Thoracic lymphangiectasis presenting with chyloptysis and bronchial cast expectoration. (12522631)
2002
33
Chylous reflux into localized pulmonary lymphangiectasis. (12173851)
2002
34
Persistence of MA1llerian derivatives and intestinal lymphangiectasis in two newborn brothers: confirmation of the Urioste syndrome. (11746031)
2001
35
A case of cutaneous lymphangiectasis secondary to breast cancer treatment. (11903671)
2001
36
Lymphangiectasis with iniencephaly. (11844186)
2001
37
Thoracic lymphangiomas, lymphangiectasis, lymphangiomatosis, and lymphatic dysplasia syndrome. (10712360)
2000
38
Congenital unilobar pulmonary lymphangiectasis. (10230931)
1999
39
Acquired lymphangiectasis. (9932832)
1999
40
Treatment of acquired cutaneous lymphangiectasis of the thigh and vulva with a carbon dioxide laser. (10430005)
1999
41
Lymphangioma and congenital pulmonary lymphangiectasis: a histologic, immunohistochemical, and clinicopathologic comparison. (10392631)
1999
42
Cutaneous lymphangiectasis: treatment with sclerotherapy. (9462778)
1998
43
Acquired lymphangiectasis following mastectomy and radiation therapy--report of a case and review of the literature. (8894426)
1996
44
Benign transient lymphangiectasis. (8854157)
1996
45
Progressive lymphangiectasis and recurrent chylothorax in a dog after thoracic duct ligation. (7559046)
1995
46
Unilateral lymphangiectasis of the kidney: an unusual cause of renal enlargement in an infant. (7815616)
1995
47
Congenital pulmonary lymphangiectasis presenting as a unilateral hyperlucent lung. (8181508)
1994
48
Pancreatic lymphangiectasis. (7942757)
1994
49
Persistence of mA1llerian derivatives, lymphangiectasis, hepatic failure, postaxial polydactyly, renal and craniofacial anomalies. (8256813)
1993
50
Congenital pulmonary lymphangiectasis with chylothorax: a heterogeneous lymphatic vessel abnormality. (8368253)
1993

Variations for Lymphangiectasis

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Expression for genes affiliated with Lymphangiectasis

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Search GEO for disease gene expression data for Lymphangiectasis.

Pathways for genes affiliated with Lymphangiectasis

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Pathways related to Lymphangiectasis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.1ACTC1, VIM
29.1ACTC1, VIM

GO Terms for genes affiliated with Lymphangiectasis

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Cellular components related to Lymphangiectasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1focal adhesionGO:00059259.1ACTC1, VIM

Biological processes related to Lymphangiectasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.8ACTC1, VIM
2positive regulation of gene expressionGO:00106289.1ACTC1, VIM

Sources for Lymphangiectasis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet