MCID: LYM035
MIFTS: 27

Lymphangiectasis

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Lymphangiectasis

MalaCards integrated aliases for Lymphangiectasis:

Name: Lymphangiectasis 50 69
Lymphangiectasia 50

Classifications:



Summaries for Lymphangiectasis

MalaCards based summary : Lymphangiectasis, also known as lymphangiectasia, is related to hennekam lymphangiectasia-lymphedema syndrome 2 and hennekam lymphangiectasia-lymphedema syndrome 1. An important gene associated with Lymphangiectasis is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Striated Muscle Contraction. The drugs Everolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and endothelial.

Wikipedia : 72 Lymphangiectasia is a pathologic dilation of lymph vessels. When it occurs in the intestines of dogs,... more...

Related Diseases for Lymphangiectasis

Diseases related to Lymphangiectasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
id Related Disease Score Top Affiliating Genes
1 hennekam lymphangiectasia-lymphedema syndrome 2 12.2
2 hennekam lymphangiectasia-lymphedema syndrome 1 10.8
3 lymphangiectasia, pulmonary, congenital 10.8
4 mullerian derivatives, persistence of, with lymphangiectasia and postaxial polydactyly 10.8
5 hennekam syndrome 10.8
6 primary intestinal lymphangiectasia 10.8
7 lymphocytic hypophysitis 10.0 ACTC1 VIM
8 gastric signet ring cell adenocarcinoma 10.0 ACTC1 VIM
9 aortic aneurysm 10.0 ACTC1 VIM
10 iridogoniodysgenesis and skeletal anomalies 10.0 ACTC1 VIM
11 esophagus leiomyosarcoma 10.0 ACTC1 VIM
12 spleen angiosarcoma 10.0 ACTC1 VIM
13 lymphangioma 10.0
14 myoma 9.9 ACTC1 VIM
15 skin lipoma 9.9 ACTC1 VIM
16 laryngeal neuroendocrine tumor 9.9 ACTC1 VIM
17 uniparental disomy of chromosome 11 9.9 ACTC1 VIM
18 myxoid leiomyosarcoma 9.9 ACTC1 VIM
19 berk-tabatznik syndrome 9.9 ACTC1 VIM
20 lymphangiosarcoma 9.9 ACTC1 VIM
21 follicular infundibulum tumor 9.9 ACTC1 VIM
22 fallopian tube germ cell cancer 9.9 ACTC1 VIM
23 papillary glioneuronal tumor 9.9 ACTC1 VIM
24 spindle cell liposarcoma 9.9 ACTC1 VIM
25 sebaceous adenoma 9.9 ACTC1 VIM
26 juvenile xanthogranuloma 9.9 ACTC1 VIM
27 subependymal glioma 9.9 ACTC1 VIM
28 short-rib thoracic dysplasia 12 9.9 ACTC1 VIM
29 coronary restenosis 9.9 ACTC1 VIM
30 pulmonary venoocclusive disease 9.9 ACTC1 VIM
31 nephrogenic adenoma of urinary bladder 9.9 ACTC1 VIM
32 group b strep disease in newborns 9.9 ACTC1 VIM
33 glomangioma 9.9 ACTC1 VIM
34 large cell acanthoma 9.9 ACTC1 VIM
35 dense deposit disease 9.9 ACTC1 VIM
36 multiple mitochondrial dysfunctions syndrome 2 9.9 ACTC1 VIM
37 patent ductus arteriosus and bicuspid aortic valve with hand anomalies 9.9 ACTC1 VIM
38 benign familial neonatal epilepsy 9.8 ACTC1 VIM
39 breast cancer 9.8
40 polyosteolysis/hyperostosis syndrome 9.8 ACTC1 VIM
41 angelman syndrome due to imprinting defect in 15q11-q13 9.8 ACTC1 VIM
42 esophagus leiomyoma 9.8 ACTC1 VIM
43 fibula aplasia complex brachydactyly 9.8 ACTC1 VIM
44 hyperpituitarism 9.8 ACTC1 VIM
45 linitis plastica 9.8 ACTC1 VIM
46 small cell neuroendocrine carcinoma 9.8 ACTC1 VIM
47 cerebrum cancer 9.8 ACTC1 VIM
48 osteomalacia 9.8
49 protein-losing enteropathy 9.8
50 constrictive pericarditis 9.8

Graphical network of the top 20 diseases related to Lymphangiectasis:



Diseases related to Lymphangiectasis

Symptoms & Phenotypes for Lymphangiectasis

Drugs & Therapeutics for Lymphangiectasis

Drugs for Lymphangiectasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 2 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
4 Anti-Bacterial Agents Phase 2
5 Antibiotics, Antitubercular Phase 2
6 Antifungal Agents Phase 2
7 Anti-Infective Agents Phase 2
8 Immunosuppressive Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2 sirolimus
2 Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders Recruiting NCT02156115
3 International Lymphatic Disease and Lymphedema Registry Recruiting NCT01336790

Search NIH Clinical Center for Lymphangiectasis

Genetic Tests for Lymphangiectasis

Anatomical Context for Lymphangiectasis

MalaCards organs/tissues related to Lymphangiectasis:

39
Breast, Lung, Endothelial, Testes, Kidney, Spleen, Heart

Publications for Lymphangiectasis

Articles related to Lymphangiectasis:

(show top 50) (show all 119)
id Title Authors Year
1
Acquired lymphangiectasis following surgery and radiotherapy of breast cancer. ( 25657438 )
2015
2
Severe primary pulmonary lymphangiectasis in a premature infant: management and follow up to early childhood. ( 25711257 )
2015
3
Reply to scurry et Al.: vulvar lymphangiectasis, an indicator of lymph stasis, is an authentic sign of abnormal histopathology in labiaplasty specimens. ( 25811280 )
2015
4
Congenital pulmonary lymphangiectasis. ( 24997116 )
2014
5
Mildly progressive pulmonary lymphangiectasis diagnosed in a young adult. ( 24684358 )
2014
6
A case of transient lymphangiectasis of the penis. ( 24846179 )
2014
7
Removal of lymphangiectasis using high-frequency radio wave electrosurgery. ( 22968357 )
2013
8
Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage. ( 22328411 )
2012
9
Firm cord-like band over the penile shaft. Benign transient lymphangiectasis of the penis. ( 22182374 )
2012
10
Osteomalacia and osteoporosis associated with primary intestinal lymphangiectasis. ( 22800909 )
2012
11
Congenital pulmonary lymphangiectasis: report of an autopsy case masquerading as pulmonary interstitial emphysema. ( 20399027 )
2010
12
Conjunctival Lymphangiectasis. ( 20429497 )
2010
13
In-transit metastasis from melanoma presenting as lymphangiectasis: a case report. ( 19842575 )
2009
14
Lymphangiectasis of lower limb. ( 20368869 )
2009
15
Lymphangiectasis of lower limb: A rare challenging case. ( 20368868 )
2009
16
Outcome of children with pulmonary lymphangiectasis. ( 19330773 )
2009
17
Combination technique of radiofrequency ablation with sclerotherapy in acquired lymphangiectasis of the vulva. ( 20300370 )
2009
18
Congenital pulmonary lymphangiectasis. ( 19172338 )
2009
19
The Multi-Detector CT findings of giant abdominal lymphangiectasis mimicking a mesenteric cystic mass in a patient with midgut volvulus. ( 25610038 )
2008
20
Osteomalacia in a patient with primary intestinal lymphangiectasis (Waldmann's disease). ( 17900962 )
2008
21
An adult with a cord round the neck: benign transient lymphangiectasis of the penis. ( 17921623 )
2007
22
Clinico-pathological characteristics of congenital pulmonary lymphangiectasis: report of two cases. ( 17728521 )
2007
23
Pulmonary lymphangiectasis in an asymptomatic adult. ( 16179818 )
2006
24
Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis. ( 16772393 )
2006
25
Congenital pulmonary lymphangiectasis sequence: a rare, heterogeneous, and lethal etiology for prenatal pleural effusion. ( 16941717 )
2006
26
Autopsy case of congenital pulmonary lymphangiectasis. ( 15189509 )
2004
27
Acquired lymphangiectasis after breast conservation treatment for breast cancer: report of a case. ( 15347491 )
2004
28
Unilobar congenital pulmonary lymphangiectasis mimicking congenital lobar emphysema: an underestimated presentation? ( 15136998 )
2004
29
Congenital pulmonary lymphangiectasis. ( 14686556 )
2003
30
Primary pulmonary lymphangiectasis in a premature infant: resolution following intensive care. ( 12687599 )
2003
31
Surgical management of conjunctival lymphangiectasis by conjunctival resection. ( 14516817 )
2003
32
Thoracic lymphangiectasis presenting with chyloptysis and bronchial cast expectoration. ( 12522631 )
2002
33
Chylous reflux into localized pulmonary lymphangiectasis. ( 12173851 )
2002
34
A case of cutaneous lymphangiectasis secondary to breast cancer treatment. ( 11903671 )
2001
35
Lymphangiectasis with iniencephaly. ( 11844186 )
2001
36
Persistence of MA1llerian derivatives and intestinal lymphangiectasis in two newborn brothers: confirmation of the Urioste syndrome. ( 11746031 )
2001
37
Thoracic lymphangiomas, lymphangiectasis, lymphangiomatosis, and lymphatic dysplasia syndrome. ( 10712360 )
2000
38
Treatment of acquired cutaneous lymphangiectasis of the thigh and vulva with a carbon dioxide laser. ( 10430005 )
1999
39
Congenital unilobar pulmonary lymphangiectasis. ( 10230931 )
1999
40
Lymphangioma and congenital pulmonary lymphangiectasis: a histologic, immunohistochemical, and clinicopathologic comparison. ( 10392631 )
1999
41
Acquired lymphangiectasis. ( 9932832 )
1999
42
Cutaneous lymphangiectasis: treatment with sclerotherapy. ( 9462778 )
1998
43
Benign transient lymphangiectasis. ( 8854157 )
1996
44
Acquired lymphangiectasis following mastectomy and radiation therapy--report of a case and review of the literature. ( 8894426 )
1996
45
Unilateral lymphangiectasis of the kidney: an unusual cause of renal enlargement in an infant. ( 7815616 )
1995
46
Progressive lymphangiectasis and recurrent chylothorax in a dog after thoracic duct ligation. ( 7559046 )
1995
47
Pancreatic lymphangiectasis. ( 7942757 )
1994
48
Congenital pulmonary lymphangiectasis presenting as a unilateral hyperlucent lung. ( 8181508 )
1994
49
Congenital pulmonary lymphangiectasis with chylothorax: a heterogeneous lymphatic vessel abnormality. ( 8368253 )
1993
50
Persistence of mA1llerian derivatives, lymphangiectasis, hepatic failure, postaxial polydactyly, renal and craniofacial anomalies. ( 8256813 )
1993

Variations for Lymphangiectasis

Expression for Lymphangiectasis

Search GEO for disease gene expression data for Lymphangiectasis.

Pathways for Lymphangiectasis

Pathways related to Lymphangiectasis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.44 ACTC1 VIM
2 10.48 ACTC1 VIM

GO Terms for Lymphangiectasis

Cellular components related to Lymphangiectasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 8.62 ACTC1 VIM

Biological processes related to Lymphangiectasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 8.96 ACTC1 VIM
2 muscle filament sliding GO:0030049 8.62 ACTC1 VIM

Sources for Lymphangiectasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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