MCID: LYM035
MIFTS: 31

Lymphangiectasis

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Lymphangiectasis

MalaCards integrated aliases for Lymphangiectasis:

Name: Lymphangiectasis 49 69
Lymphangiectasia 49

Classifications:



External Ids:

UMLS 69 C0024214

Summaries for Lymphangiectasis

MalaCards based summary : Lymphangiectasis, also known as lymphangiectasia, is related to mullerian derivatives, persistence of, with lymphangiectasia and postaxial polydactyly and lymphangiectasia, pulmonary, congenital. An important gene associated with Lymphangiectasis is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Striated Muscle Contraction. The drugs Miconazole and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and endothelial.

Wikipedia : 72 Lymphangiectasia is a pathologic dilation of lymph vessels. When it occurs in the intestines of dogs,... more...

Related Diseases for Lymphangiectasis

Diseases related to Lymphangiectasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 mullerian derivatives, persistence of, with lymphangiectasia and postaxial polydactyly 11.2
2 lymphangiectasia, pulmonary, congenital 11.0
3 hennekam syndrome 10.9
4 lymphangiectasia, intestinal 10.9
5 hennekam lymphangiectasia-lymphedema syndrome 1 10.9
6 primary intestinal lymphangiectasia 10.9
7 lymphangioma 10.0
8 glomangiomyoma 9.9 ACTC1 VIM
9 angiolipoma 9.9 ACTC1 VIM
10 intravascular papillary endothelial hyperplasia 9.9 ACTC1 VIM
11 cutaneous leiomyosarcoma 9.9 ACTC1 VIM
12 spindle cell lipoma 9.9 ACTC1 VIM
13 parachordoma 9.9 ACTC1 VIM
14 ossifying fibromyxoid tumor 9.9 ACTC1 VIM
15 epithelioid leiomyosarcoma 9.9 ACTC1 VIM
16 syringocystadenoma papilliferum 9.9 ACTC1 VIM
17 benign metastasizing leiomyoma 9.9 ACTC1 VIM
18 adenofibroma 9.9 ACTC1 VIM
19 congenital fibrosarcoma 9.9 ACTC1 VIM
20 angiocentric glioma 9.9 ACTC1 VIM
21 pleomorphic liposarcoma 9.9 ACTC1 VIM
22 perivascular epithelioid cell tumor 9.9 ACTC1 VIM
23 cutaneous fibrous histiocytoma 9.9 ACTC1 VIM
24 reticulum cell sarcoma 9.9 ACTC1 VIM
25 spindle cell sarcoma 9.9 ACTC1 VIM
26 spiradenoma 9.9 ACTC1 VIM
27 pseudosarcomatous fibromatosis 9.9 ACTC1 VIM
28 glomus tumor 9.9 ACTC1 VIM
29 dendritic cell tumor 9.9 ACTC1 VIM
30 granulosa cell tumor of the ovary 9.9 ACTC1 VIM
31 infantile myofibromatosis 9.8 ACTC1 VIM
32 smooth muscle tumor 9.8 ACTC1 VIM
33 hemangiopericytoma, malignant 9.8 ACTC1 VIM
34 peritonitis 9.8
35 noonan syndrome 1 9.8
36 osteomalacia 9.8
37 protein-losing enteropathy 9.8
38 constrictive pericarditis 9.8
39 pseudo-turner syndrome 9.8
40 pericarditis 9.8
41 polymorphous low-grade adenocarcinoma 9.8 ACTC1 VIM
42 malignant fibroxanthoma 9.8 ACTC1 VIM
43 chondromyxoid fibroma 9.8 ACTC1 VIM
44 fasciitis 9.8 ACTC1 VIM
45 fibromatosis 9.8 ACTC1 VIM
46 glomangioma 9.8 ACTC1 VIM
47 myoepithelioma 9.8 ACTC1 VIM
48 spindle cell carcinoma 9.8 ACTC1 VIM
49 rhabdoid cancer 9.8 ACTC1 VIM
50 desmoplastic small round cell tumor 9.8 ACTC1 VIM

Graphical network of the top 20 diseases related to Lymphangiectasis:



Diseases related to Lymphangiectasis

Symptoms & Phenotypes for Lymphangiectasis

Drugs & Therapeutics for Lymphangiectasis

Drugs for Lymphangiectasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
4 Anti-Bacterial Agents Phase 2
5 Anti-Infective Agents Phase 2
6 Antifungal Agents Phase 2
7 Immunosuppressive Agents Phase 2
8 Antibiotics, Antitubercular Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2 sirolimus
2 Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders Recruiting NCT02156115
3 International Lymphatic Disease and Lymphedema Registry Recruiting NCT01336790

Search NIH Clinical Center for Lymphangiectasis

Genetic Tests for Lymphangiectasis

Anatomical Context for Lymphangiectasis

MalaCards organs/tissues related to Lymphangiectasis:

38
Breast, Lung, Endothelial, Testes, Kidney, Spleen, Heart

Publications for Lymphangiectasis

Articles related to Lymphangiectasis:

(show top 50) (show all 119)
# Title Authors Year
1
Acquired lymphangiectasis following surgery and radiotherapy of breast cancer. ( 25657438 )
2015
2
Reply to scurry et Al.: vulvar lymphangiectasis, an indicator of lymph stasis, is an authentic sign of abnormal histopathology in labiaplasty specimens. ( 25811280 )
2015
3
Severe primary pulmonary lymphangiectasis in a premature infant: management and follow up to early childhood. ( 25711257 )
2015
4
Mildly progressive pulmonary lymphangiectasis diagnosed in a young adult. ( 24684358 )
2014
5
Congenital pulmonary lymphangiectasis. ( 24997116 )
2014
6
A case of transient lymphangiectasis of the penis. ( 24846179 )
2014
7
Removal of lymphangiectasis using high-frequency radio wave electrosurgery. ( 22968357 )
2013
8
Osteomalacia and osteoporosis associated with primary intestinal lymphangiectasis. ( 22800909 )
2012
9
Firm cord-like band over the penile shaft. Benign transient lymphangiectasis of the penis. ( 22182374 )
2012
10
Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage. ( 22328411 )
2012
11
Conjunctival Lymphangiectasis. ( 20429497 )
2010
12
Congenital pulmonary lymphangiectasis: report of an autopsy case masquerading as pulmonary interstitial emphysema. ( 20399027 )
2010
13
Combination technique of radiofrequency ablation with sclerotherapy in acquired lymphangiectasis of the vulva. ( 20300370 )
2009
14
Congenital pulmonary lymphangiectasis. ( 19172338 )
2009
15
Lymphangiectasis of lower limb. ( 20368869 )
2009
16
Lymphangiectasis of lower limb: A rare challenging case. ( 20368868 )
2009
17
Outcome of children with pulmonary lymphangiectasis. ( 19330773 )
2009
18
In-transit metastasis from melanoma presenting as lymphangiectasis: a case report. ( 19842575 )
2009
19
The Multi-Detector CT findings of giant abdominal lymphangiectasis mimicking a mesenteric cystic mass in a patient with midgut volvulus. ( 25610038 )
2008
20
Osteomalacia in a patient with primary intestinal lymphangiectasis (Waldmann's disease). ( 17900962 )
2008
21
An adult with a cord round the neck: benign transient lymphangiectasis of the penis. ( 17921623 )
2007
22
Clinico-pathological characteristics of congenital pulmonary lymphangiectasis: report of two cases. ( 17728521 )
2007
23
Congenital pulmonary lymphangiectasis sequence: a rare, heterogeneous, and lethal etiology for prenatal pleural effusion. ( 16941717 )
2006
24
Pulmonary lymphangiectasis in an asymptomatic adult. ( 16179818 )
2006
25
Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis. ( 16772393 )
2006
26
Unilobar congenital pulmonary lymphangiectasis mimicking congenital lobar emphysema: an underestimated presentation? ( 15136998 )
2004
27
Autopsy case of congenital pulmonary lymphangiectasis. ( 15189509 )
2004
28
Acquired lymphangiectasis after breast conservation treatment for breast cancer: report of a case. ( 15347491 )
2004
29
Primary pulmonary lymphangiectasis in a premature infant: resolution following intensive care. ( 12687599 )
2003
30
Surgical management of conjunctival lymphangiectasis by conjunctival resection. ( 14516817 )
2003
31
Congenital pulmonary lymphangiectasis. ( 14686556 )
2003
32
Thoracic lymphangiectasis presenting with chyloptysis and bronchial cast expectoration. ( 12522631 )
2002
33
Chylous reflux into localized pulmonary lymphangiectasis. ( 12173851 )
2002
34
A case of cutaneous lymphangiectasis secondary to breast cancer treatment. ( 11903671 )
2001
35
Lymphangiectasis with iniencephaly. ( 11844186 )
2001
36
Persistence of MA1llerian derivatives and intestinal lymphangiectasis in two newborn brothers: confirmation of the Urioste syndrome. ( 11746031 )
2001
37
Thoracic lymphangiomas, lymphangiectasis, lymphangiomatosis, and lymphatic dysplasia syndrome. ( 10712360 )
2000
38
Lymphangioma and congenital pulmonary lymphangiectasis: a histologic, immunohistochemical, and clinicopathologic comparison. ( 10392631 )
1999
39
Acquired lymphangiectasis. ( 9932832 )
1999
40
Treatment of acquired cutaneous lymphangiectasis of the thigh and vulva with a carbon dioxide laser. ( 10430005 )
1999
41
Congenital unilobar pulmonary lymphangiectasis. ( 10230931 )
1999
42
Cutaneous lymphangiectasis: treatment with sclerotherapy. ( 9462778 )
1998
43
Benign transient lymphangiectasis. ( 8854157 )
1996
44
Acquired lymphangiectasis following mastectomy and radiation therapy--report of a case and review of the literature. ( 8894426 )
1996
45
Unilateral lymphangiectasis of the kidney: an unusual cause of renal enlargement in an infant. ( 7815616 )
1995
46
Progressive lymphangiectasis and recurrent chylothorax in a dog after thoracic duct ligation. ( 7559046 )
1995
47
Congenital pulmonary lymphangiectasis presenting as a unilateral hyperlucent lung. ( 8181508 )
1994
48
Pancreatic lymphangiectasis. ( 7942757 )
1994
49
Persistence of mA1llerian derivatives, lymphangiectasis, hepatic failure, postaxial polydactyly, renal and craniofacial anomalies. ( 8256813 )
1993
50
Epididymal lymphangiectasis. ( 8371406 )
1993

Variations for Lymphangiectasis

Expression for Lymphangiectasis

Search GEO for disease gene expression data for Lymphangiectasis.

Pathways for Lymphangiectasis

Pathways related to Lymphangiectasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 ACTC1 VIM
2 10.48 ACTC1 VIM

GO Terms for Lymphangiectasis

Cellular components related to Lymphangiectasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 8.62 ACTC1 VIM

Biological processes related to Lymphangiectasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 8.96 ACTC1 VIM
2 muscle filament sliding GO:0030049 8.62 ACTC1 VIM

Sources for Lymphangiectasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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