LAM
MCID: LYM007
MIFTS: 67

Lymphangioleiomyomatosis (LAM) malady

Respiratory, Immune categories

Summaries for Lymphangioleiomyomatosis

Sources:
21Genetics Home Reference, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Lymphangioleiomyomatosis (lim-fan-je-o-li-o-mi-o-ma-to-sis), or lam, is a rare lung disease that mostly affects women in their mid-forties. in lam, an unusual type of cell begins to grow out of control throughout the body, including in the lungs, lymph nodes and vessels, and kidneys. over time, these lam cells form cysts and clusters of cells, which grow throughout the lungs and slowly block the airways. they also destroy the normal lung tissue and replace it with cysts. as a result, air cannot move freely in and out of the lungs, and the lungs cannot supply enough oxygen to the body’s other organs.more than 1 out of every 3 people with lam also develops growths called angiomyolipomas, or amls, in their kidneys. people with lam also may develop:growths in other organs, including the liver and brain large tumors on their lymph nodesthere are two forms of lam:sporadic lam, which occurs for unknown reasons lam that occurs in people with a rare inherited disease called tuberous sclerosis complex. this is often a milder form. last updated: 7/16/2013

MalaCards: Lymphangioleiomyomatosis, also known as lymphangiomyomatosis, is related to tuberous sclerosis and angiomyolipoma, and has symptoms including lung/pulmonary infiltrates, thoracic/chest pain and respiratory distress/dyspnea/respiratory failure/lung volume reduction. An important gene associated with Lymphangioleiomyomatosis is TSC1 (tuberous sclerosis 1), and among its related pathways are p70S6K Signaling and Inhibition of TSC complex formation by PKB. The compounds matrigel and alendronate have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and heart, and related mouse phenotypes are muscle and tumorigenesis.

Genetics Home Reference:21 Lymphangioleiomyomatosis (LAM) is a condition that affects the lungs, the kidneys, and the lymphatic system. The lymphatic system consists of a network of vessels that transport lymph fluid and immune cells throughout the body.

Wikipedia:64 Lymphangioleiomyomatosis (LAM) is a rare lung disease that results in a proliferation of disorderly... more...

Description from OMIM:47 606690

Aliases & Classifications for Lymphangioleiomyomatosis

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 22GTR, 35MeSH, 40NCIt, 57SNOMED-CT, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory, Immune


Characteristics (Orphanet epidemiological data):

49
lymphangioleiomyomatosis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Adulthood


Aliases & Descriptions:

lymphangioleiomyomatosis 8 9 43 21 47 10 45 49 61
lymphangiomyomatosis 8 21 45
lam 43 21 49
pulmonary lymphangioleiomyomatosis 8 61
lymphangio-myomatosis 43 22
lung lymphangioleiomyomatosis 8


External Ids:

Disease Ontology8 DOID:3319
MeSH35 D018192
NCIt40 C38153
OMIM47 606690
SNOMED-CT57 277844007
MESH via Orphanet36 D018192
ICD10 via Orphanet26 J98.4
SNOMED-CT via Orphanet58 73017001
UMLS via Orphanet62 C0751674

Related Diseases for Lymphangioleiomyomatosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Lymphangioleiomyomatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1tuberous sclerosis31.2TSC2, TSC1, RHOD, MTOR, CCL26
2angiomyolipoma31.0TSC2, TSC1, ESR1, ACTC1, PGR, DES
3tuberous sclerosis complex30.9TSC2, TSC1
4perivascular epithelioid cell tumor30.3TSC2, MLANA
5idiopathic pulmonary fibrosis30.2S100A1, MMP1, ACTC1
6endometrial stromal sarcoma30.0DES, PGR, ACTC1, ESR1
7smooth muscle tumor30.0S100A1, DES, PGR, ACTC1, ESR1
8papillary carcinoma30.0S100A1, VEGFC, PGR, ACTC1, ESR1
9angiosarcoma29.8ACTC1, VEGFC
10epithelioid leiomyosarcoma29.8DES, ACTC1
11polycystic kidney disease29.8MTOR, TSC1, TSC2
12vascular disease29.8ESR1, MMP2
13adenoma29.8S100A1, IGF1R, FIGF, ACTC1, TSC1
14amenorrhea10.4
15spontaneous pneumothorax10.4
16endosalpingiosis10.2
17chylous ascites10.2
18pulmonary function10.2
19benign metastasizing leiomyoma10.1
20hepatic angiomyolipoma10.0
21birt–hogg–dubé syndrome10.0
22tsc1-related lymphangioleiomyomatosis10.0
23birt-hogg-dub� syndrome10.0
24lymphangioleiomyomatosis, somatic10.0
25tuberculosis10.0
26hypercholesterolemia10.0
27pneumothorax10.0TSC1
28kidney rhabdoid cancer10.0TSC2
29thyroid cancer10.0VEGFC
30kidney cancer10.0MTOR
31esophagitis10.0CCL26
32sertoli-leydig cell tumor10.0PGR
33cystadenoma10.0VEGFC
34hemangioma10.0ACTC1
35syringoma10.0S100A1
36glaucoma10.0MMP1
37fasciitis10.0ACTC1
38bladder carcinoma10.0TSC1
39leiomyomatosis10.0ESR1, PGR
40leukemia10.0MTOR, SRF
41papilloma10.0ACTC1
42obesity10.0MTOR
43chordoma10.0DES, S100A1
44laryngeal carcinoma10.0MMP2, VEGFC
45desmoid tumor10.0ACTC1, DES
46malignant mesothelioma10.0DES, S100A1
47infantile myofibromatosis10.0DES
48paraganglioma10.0S100A1
49polycystic ovary syndrome10.0IGF1R
50kidney angiomyolipoma10.0MTOR, TSC1, TSC2

Graphical network of the top 20 diseases related to Lymphangioleiomyomatosis:



Diseases related to lymphangioleiomyomatosis

Clinical Features for Lymphangioleiomyomatosis

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

606690

Symptoms:

49 (show all 36)
  • lung/pulmonary infiltrates
  • thoracic/chest pain
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • anomalies of the lymphatic system
  • cutaneous neurofibromas/facial angiofibromas/koenen tumors
  • ungual/paraungual fibromas (fingernails)
  • acute abdominal pain/colic
  • emphysema
  • atelectasia/pulmonary collapse
  • lymphadenopathy/polyadenopathies
  • multicystic kidney/renal dysplasia
  • hematuria/microhematuria
  • uterine/uterus/fallopian tubes anomalies
  • retinal hamartoma
  • optic nerve anomaly/optic atrophy/anomaly of the papilla
  • anomalies of eyelids, eyelashes and lacrimal system
  • shagreen patch
  • macules
  • abnormal pigmentary skin changes/skin pigmentation anomalies
  • ascitis
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • hemoptysis
  • repeat respiratory infections
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • lymphedema
  • polycystic kidneys
  • abnormal colour of the urine/cholic/dark urines
  • hydrocephaly
  • seizures/epilepsy/absences/spasms/status epilepticus
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • kidney/renal neoplasm/tumor/carcinoma/cancer
  • fever/chilling
  • asthenia/fatigue/weakness

Drugs & Therapeutics for Lymphangioleiomyomatosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lymphangioleiomyomatosis

Drug clinical trials:

Search ClinicalTrials for Lymphangioleiomyomatosis

Search NIH Clinical Center for Lymphangioleiomyomatosis

Search CenterWatch for Lymphangioleiomyomatosis

Genetic Tests for Lymphangioleiomyomatosis

Sources:
22GTR
See all sources

Genetic tests related to Lymphangioleiomyomatosis:

id Genetic test Affiliating Genes
1 Lymphangiomyomatosis22

Anatomical Context for Lymphangioleiomyomatosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Lymphangioleiomyomatosis:

33
Lymph node, Brain, Heart, Smooth muscle, Colon, Kidney, Liver, Lung, Thyroid, Uterus, T cells, Endothelial

Animal Models for Lymphangioleiomyomatosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Lymphangioleiomyomatosis

Sources:
51PubMed
See all sources

Articles related to Lymphangioleiomyomatosis:

(show top 50)    (show all 510)
idTitleAuthorsYear
1
Sirolimus decreases circulating lymphangioleiomyomatosis cells in patients with lymphangioleiomyomatosis. (24051985)
2014
2
Tuberous sclerosis presenting with spontaneous pneumothorax secondary to lymphangioleiomyomatosis; previously mistaken for asthma. (23729718)
2013
3
A biomarker for lymphangioleiomyomatosis. (24429226)
2013
4
Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial. (23312829)
2013
5
Peritoneovenous shunt for chylous ascites after lung transplantation for lymphangioleiomyomatosis. (22664021)
2012
6
Development of a lymphangioleiomyomatosis model by endonasal administration of human TSC2-/- smooth muscle cells in mice. (22770663)
2012
7
Chyloperitoneum, chylothorax and lower extremity lymphedema in woman with sporadic lymphangioleiomyomatosis successfully treated with sirolimus: a case report. (23057149)
2012
8
Differentiation between Birt-Hogg-DubAc syndrome and lymphangioleiomyomatosis: quantitative analysis of pulmonary cysts on computed tomography of the chest in 66 females. (21550193)
2012
9
Bilateral pneumothorax in pregnancy unmasking lymphangioleiomyomatosis. (21076889)
2011
10
Successful pregnancy complicated by persistent pneumothorax in a patient with lymphangioleiomyomatosis (LAM) on sirolimus. (22117507)
2011
11
Bilateral spontaneous tension pneumothorax secondary to lymphangioleiomyomatosis. (21610418)
2011
12
Lymphangioleiomyomatosis (LAM): molecular insights lead to targeted therapies. (20630348)
2010
13
Lymphangioleiomyomatosis and TSC2-/- cells. (20235888)
2010
14
Atypical presentation of lymphangioleiomyomatosis as jugular vein thrombosis. (20335435)
2010
15
CT of sclerotic bone lesions: imaging features differentiating tuberous sclerosis complex with lymphangioleiomyomatosis from sporadic lymphangioleiomymatosis. (20177097)
2010
16
Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene. (19155472)
2009
17
Reversible airflow obstruction in lymphangioleiomyomatosis. (19447921)
2009
18
Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis. (19596836)
2009
19
Pulmonary lymphangioleiomyomatosis: unusual manifestations of multiple large pulmonary nodules with retroperitoneal lymph node involvement mimicking metastatic malignancy. (21904573)
2009
20
Lymphangioleiomyomatosis: a case report. (19361321)
2009
21
Pulmonary edema as a complication of transcatheter embolization of renal angiomyolipoma in a patient with pulmonary lymphangioleiomyomatosis due to tuberous sclerosis complex. (19465308)
2009
22
Pregnancy experiences among women with lymphangioleiomyomatosis. (19117742)
2009
23
Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation. (18094073)
2008
24
Extrapulmonary lymphangioleiomyomatosis: an unusual cause of biliary tract obstruction. (18219066)
2008
25
Chylous vaginal discharge in a patient with lymphangioleiomyomatosis. (18501322)
2008
26
Effect of a gonadotrophin-releasing hormone analogue on lung function in lymphangioleiomyomatosis. (18071009)
2008
27
Regression of pulmonary lymphangioleiomyomatosis (PLAM)-associated retroperitoneal angiomyolipoma post-lung transplantation with rapamycin treatment. (18374885)
2008
28
Efficacy of hormonal manipulation in lymphangioleiomyomatosis. A 20-year-experience in 36 patients. (18069418)
2007
29
Multiple cysts in the kidney and lungs in a patient with polycystic kidney disease and lymphangioleiomyomatosis. (17334601)
2007
30
Lymphangioleiomyomatosis. (17075565)
2006
31
Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2. (16424383)
2006
32
Clinical and molecular insights into lymphangioleiomyomatosis. (16457017)
2005
33
Lymphangioleiomyomatosis: clinical, pathologic, and radiologic manifestations. (15818208)
2005
34
Lymphangioleiomyomatosis. (15331193)
2004
35
Low initial KCO predicts rapid FEV1 decline in pulmonary lymphangioleiomyomatosis. (15191039)
2004
36
Molecular and genetic analysis of disseminated neoplastic cells in lymphangioleiomyomatosis. (15583138)
2004
37
Pulmonary cysts consistent with lymphangioleiomyomatosis are common in women with tuberous sclerosis: genetic and radiographic analysis. (11893688)
2002
38
Basic fibroblast growth factor and its receptors in idiopathic pulmonary fibrosis and lymphangioleiomyomatosis. (12204879)
2002
39
Exacerbation of pulmonary lymphangioleiomyomatosis by exogenous oestrogen used for infertility treatment. (12454306)
2002
40
Nephron-sparing nephrectomy for giant renal angiomyolipoma associated with lymphangioleiomyomatosis. (11796307)
2002
41
Meningiomas in lymphangioleiomyomatosis. (11597290)
2001
42
Pulmonary lymphangioleiomyomatosis. Morphologic and immunohistochemical findings]. (11402850)
2001
43
Oestrogen metabolism in lymphangioleiomyomatosis: catechol-O-methyltransferase pathway is not involved. (10856317)
2000
44
Retroperitoneal lymphangioleiomyomatosis. (9880962)
1998
45
Lymphangioleiomyomatosis of the uterus simulating high-stage endometrial stromal sarcoma. (8946880)
1996
46
Pulmonary lymphangioleiomyomatosis and tuberous sclerosis. (8730336)
1996
47
Chyloptyses found in a patient with lymphangioleiomyomatosis. (7497815)
1995
48
Response to treatment with progesterone in a patient with pulmonary lymphangioleiomyomatosis. (8533401)
1995
49
Pulmonary lymphangioleiomyomatosis. (8090585)
1994
50
Comparison of the use of antibodies to alpha smooth muscle actin and desmin in pulmonary lymphangioleiomyomatosis. (8320334)
1993

Genetic Variations for Lymphangioleiomyomatosis

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Lymphangioleiomyomatosis:

63
id Symbol AA change Variation SNP ID
1TSC2p.Arg611GlnVAR_005650

Expression for genes affiliated with Lymphangioleiomyomatosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphangioleiomyomatosis

Search GEO for disease gene expression data for Lymphangioleiomyomatosis.

Pathways for genes affiliated with Lymphangioleiomyomatosis

Sources:
52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 53R&D Systems
See all sources

Pathways related to Lymphangioleiomyomatosis according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4IGF1R
210.4TSC2, TSC1
3
Hide members
10.3FIGF, VEGFC
410.3MTOR, TSC1, TSC2
5
Hide members
10.3TSC2, TSC1, MTOR
610.3TSC2, TSC1, MTOR
710.3TSC2, TSC1, IGF1R
8
Cell adhesion ECM remodeling
Hide members
10.3MMP1, MMP2, IGF1R
910.3IGF1R, MMP2, ESR1
10
Hide members
10.2TSC2, TSC1, MMP1, MTOR
1110.2MTOR, ESR1, TSC1, TSC2
12
Translation Insulin regulation of translation
Hide members
10.2MTOR, IGF1R, TSC1, TSC2
13
Hide members
10.2TSC2, TSC1, IGF1R, MTOR
14
Hide members
10.2MTOR, IGF1R, TSC1, TSC2
15
Hide members
10.2TSC2, TSC1, IGF1R, MTOR
1610.2MTOR, IGF1R, TSC1, TSC2
17
Hide members
10.2MTOR, PGR, ESR1, TSC2
18
Development Endothelin-1/EDNRA signaling
Hide members
10.2TSC2, ESR1, MMP2, MTOR
19
Transcription Androgen Receptor nuclear signaling
Hide members
10.2MTOR, IGF1R, MMP2, TSC2
20
Hide members
10.2TSC2, TSC1, FIGF, VEGFC
2110.2MTOR, IGF1R, MMP2, ESR1
2210.2MTOR, MMP1, ESR1, TSC1, TSC2
2310.1MTOR, IGF1R, SRF, TSC1, TSC2
2410.1MTOR, VEGFC, IGF1R, FIGF, TSC1, TSC2
25
Hide members
10.1CCL26, VEGFC, IGF1R, FIGF, TSC1, TSC2
2610.1MTOR, VEGFC, IGF1R, FIGF, MMP2, MMP1
27
Hide members
10.0VEGFC, IGF1R, FIGF, MMP2, MMP1, SRF
28
Hide members
9.9MTOR, RHOD, VEGFC, IGF1R, FIGF, PGR
29
Hide members
9.9CCL26, DES, VEGFC, IGF1R, FIGF, SRF

Compounds for genes affiliated with Lymphangioleiomyomatosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Lymphangioleiomyomatosis according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1matrigel4510.6MTOR, RHOD, MMP1, ACTC1
2alendronate45 50 1112.6RHOD, MMP2, MMP1, ESR1
3trastuzumab45 50 1112.6VEGFC, IGF1R, PGR, ESR1
4glycogen45 2411.6MTOR, IGF1R, ACTC1, TSC1, TSC2
5progestin4510.6DES, IGF1R, PGR, MMP1, ESR1
6mucicarmine4510.5ACTC1, DES, S100A1
7actomyosin4510.5S100A1, RHOD, ACTC1, SRF
8vitamin a45 11 2412.5SRF, MMP1, MMP2, IGF1R
9lapatinib45 50 1112.5ESR1, PGR, IGF1R
10resveratrol45 60 11 2413.5ESR1, MMP2, PGR, IGF1R, MTOR
11dexamethasone45 50 29 1113.5MTOR, VEGFC, IGF1R, SRF
12dihydrotestosterone45 29 11 2413.5DES, IGF1R, PGR, SRF, ESR1
13pge24510.5RHOD, VEGFC, IGF1R, MMP2
14hematoxylin4510.5S100A1, MLANA, DES, MMP1, ACTC1
15creatinine4510.5IGF1R, MMP2, MMP1, ACTC1, SRF
16clomiphene citrate4510.5IGF1R, PGR, ESR1
17gefitinib45 50 1112.5ESR1, MMP2, IGF1R, MTOR
185fluorouracil4510.5MTOR, IGF1R, PGR, MMP2, SRF, ESR1
19ribonucleic acid4510.5VEGFC, IGF1R, PGR, MMP2, MMP1, ACTC1
20tibolone4510.5PGR, MMP1, ESR1
21methotrexate45 50 1112.5ESR1, SRF, MMP1, MMP2, PGR
22daidzein4510.5IGF1R, SRF, ESR1
23steroid4510.4MLANA, MTOR, DES, ACTC1, ESR1, TSC2
24doxorubicin45 50 1112.4MTOR, DES, IGF1R, PGR, MMP1, ESR1
25rapamycin4510.4CCL26, MTOR, RHOD, IGF1R, MMP1, TSC1
26pd 98,0594510.4MTOR, RHOD, VEGFC, IGF1R, MMP2, MMP1
27ly2940024510.4MTOR, RHOD, VEGFC, IGF1R, MMP2, ESR1
28Ethynodiol Diacetate1110.4PGR, ESR1
29glucose4510.4VEGFC, IGF1R, ACTC1, SRF, TSC1, TSC2
30estradiol45 11 2412.4MTOR, DES, VEGFC, IGF1R, PGR, MMP1
31phxa 854510.3MMP2, MMP1
32genistein45 29 60 2 11 2415.3MTOR, RHOD, IGF1R, PGR, MMP2, MMP1
33phosphatidylinositol4510.3MTOR, RHOD, VEGFC, IGF1R, MMP2, SRF
34lactate4510.3MLANA, DES, IGF1R, MMP2, MMP1, SRF
3512-o-tetradecanoylphorbol 13-acetate4510.3SRF, MMP1, MMP2, DES, MTOR
36levonorgestrel45 60 29 1113.3ESR1, MMP1, PGR
37serine4510.3RHOD, DES, MMP2, MMP1, SRF, TSC1
38cysteine4510.2CCL26, S100A1, RHOD, DES, IGF1R, PGR
39ici 1643844510.2PGR, ESR1
40threonine4510.2MTOR, RHOD, DES, IGF1R, SRF, TSC1
41tamoxifen45 50 29 1113.2MTOR, IGF1R, FIGF, PGR, ESR1
42testosterone45 60 11 2413.2IGF1R, VEGFC, DES, MTOR, PGR, MMP2
43oxygen45 2411.2CCL26, MTOR, RHOD, DES, VEGFC, IGF1R
44retinoic acid45 2411.1S100A1, MTOR, DES, VEGFC, IGF1R, PGR
45progesterone45 60 29 11 2414.1S100A1, DES, VEGFC, IGF1R, FIGF, PGR
46paraffin4510.1S100A1, TSC2, TSC1, ESR1, ACTC1, MMP1
47tyrosine4510.0VEGFC, DES, RHOD, MTOR, S100A1, IGF1R
48calcium45 50 11 2413.0CCL26, S100A1, MTOR, RHOD, DES, VEGFC
49taxane4510.0ESR1, PGR, MTOR
50vegf4510.0MTOR, RHOD, TSC2, TSC1, ESR1, SRF

GO Terms for genes affiliated with Lymphangioleiomyomatosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Lymphangioleiomyomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TSC1-TSC2 complexGO:03359610.4TSC2, TSC1
2membraneGO:0160209.7TSC2, TSC1, ESR1, FIGF, IGF1R, VEGFC

Biological processes related to Lymphangioleiomyomatosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell sizeGO:04579210.5TSC2, TSC1, MTOR
2positive chemotaxisGO:05091810.4TSC2, FIGF, VEGFC
3positive regulation of mast cell chemotaxisGO:06075410.4FIGF, VEGFC
4insulin receptor signaling pathwayGO:00828610.4MTOR, IGF1R, TSC1, TSC2
5protein heterooligomerizationGO:05129110.4IGF1R, TSC1, TSC2
6insulin-like growth factor receptor signaling pathwayGO:04800910.3TSC2, IGF1R
7cardiac myofibril assemblyGO:05500310.2SRF, ACTC1
8signal transductionGO:00716510.1CCL26, MTOR, VEGFC, IGF1R, PGR, ESR1
9TOR signaling cascadeGO:03192910.0RHEBL1, MTOR

Molecular functions related to Lymphangioleiomyomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor receptor 3 bindingGO:04318510.0FIGF, VEGFC
2protein bindingGO:0055159.5S100A1, MLANA, MTOR, DES, VEGFC, IGF1R

Products for genes affiliated with Lymphangioleiomyomatosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphangioleiomyomatosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet