LAM
MCID: LYM007
MIFTS: 74

Lymphangioleiomyomatosis (LAM) malady

Respiratory diseases, Immune diseases categories

Summaries for Lymphangioleiomyomatosis

About this section
Sources:
21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Lymphangioleiomyomatosis (lim-fan-je-o-li-o-mi-o-ma-to-sis), or lam, is a rare lung disease that mostly affects women in their mid-forties. in lam, an unusual type of cell begins to grow out of control throughout the body, including in the lungs, lymph nodes and vessels, and kidneys. over time, these lam cells form cysts and clusters of cells, which grow throughout the lungs and slowly block the airways. they also destroy the normal lung tissue and replace it with cysts. as a result, air cannot move freely in and out of the lungs, and the lungs cannot supply enough oxygen to the body’s other organs.more than 1 out of every 3 people with lam also develops growths called angiomyolipomas, or amls, in their kidneys. people with lam also may develop:growths in other organs, including the liver and brain large tumors on their lymph nodesthere are two forms of lam:sporadic lam, which occurs for unknown reasons lam that occurs in people with a rare inherited disease called tuberous sclerosis complex. this is often a milder form. last updated: 7/16/2013

MalaCards: Lymphangioleiomyomatosis, also known as lymphangiomyomatosis, is related to tuberous sclerosis and angiomyolipoma, and has symptoms including abnormal colour of the urine/cholic/dark urines, polycystic kidneys and lymphedema. An important gene associated with Lymphangioleiomyomatosis is TSC1 (tuberous sclerosis 1), and among its related pathways are p70S6K Signaling and Inhibition of TSC complex formation by PKB. The compounds matrigel and alendronate have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and smooth muscle, and related mouse phenotypes are muscle and tumorigenesis.

Genetics Home Reference:21 Lymphangioleiomyomatosis (LAM) is a condition that affects the lungs, the kidneys, and the lymphatic system. The lymphatic system consists of a network of vessels that transport lymph fluid and immune cells throughout the body.

Wikipedia:63 Lymphangioleiomyomatosis (LAM) is a rare lung disease that results in a proliferation of disorderly... more...

Description from OMIM:46 606690

Aliases & Classifications for Lymphangioleiomyomatosis

About this section
Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 22GTR, 34MeSH, 39NCIt, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
lymphangioleiomyomatosis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Adulthood


Aliases & Descriptions:

lymphangioleiomyomatosis 8 9 42 21 46 10 44 48 60
lymphangiomyomatosis 8 21 44
lam 42 21 48
pulmonary lymphangioleiomyomatosis 8 60
lymphangio-myomatosis 42 22
lung lymphangioleiomyomatosis 8


External Ids:

Disease Ontology8 DOID:3319
MeSH34 D018192
NCIt39 C38153
OMIM46 606690
SNOMED-CT56 277844007
MESH via Orphanet35 D018192
ICD10 via Orphanet26 J98.4
SNOMED-CT via Orphanet57 73017001
UMLS via Orphanet61 C0751674

Related Diseases for Lymphangioleiomyomatosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Lymphangioleiomyomatosis family:

Tsc1-Related Lymphangioleiomyomatosis

Diseases related to Lymphangioleiomyomatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1tuberous sclerosis31.1TSC2, TSC1, RHOD, MTOR, CCL26
2angiomyolipoma31.0TSC2, TSC1, ESR1, ACTC1, PGR, DES
3pneumothorax30.7TSC1
4leiomyoma30.3TSC2, ESR1, ACTC1, PGR, DES, S100A1
5meningioma30.3PGR, ESR1
6perivascular epithelioid cell tumor30.2TSC2, MLANA
7pulmonary fibrosis30.1MMP2, MMP1
8idiopathic pulmonary fibrosis30.1S100A1, MMP1, ACTC1
9hemangioma30.0ACTC1
10endometrial stromal sarcoma30.0DES, PGR, ACTC1, ESR1
11smooth muscle tumor30.0S100A1, DES, PGR, ACTC1, ESR1
12papillary carcinoma30.0S100A1, VEGFC, PGR, ACTC1, ESR1
13sarcoma30.0S100A1, MLANA, MTOR, DES, IGF1R, ACTC1
14leiomyomatosis29.8ESR1, PGR
15angiosarcoma29.8ACTC1, VEGFC
16kidney angiomyolipoma29.8MTOR, TSC1, TSC2
17epithelioid leiomyosarcoma29.8DES, ACTC1
18polycystic kidney disease29.8MTOR, TSC1, TSC2
19vascular disease29.8ESR1, MMP2
20leiomyosarcoma29.8S100A1, MLANA, DES, PGR, ACTC1
21papillary thyroid carcinoma29.8FIGF, VEGFC, S100A1
22ovarian cancer29.8MLANA, MTOR, RHOD, VEGFC, IGF1R, PGR
23melanoma29.7DES, RHOD, MTOR, MLANA, S100A1, PMEL
24amenorrhea10.4
25endosalpingiosis10.2
26perivascular tumor10.2
27opiate dependence10.1
28hepatitis10.1
29histiocytosis10.1
30mediastinitis10.1
31hepatic angiomyolipoma10.0
32hepatitis a10.0
33langerhans-cell histiocytosis10.0
34lymphedema10.0
35peritonitis10.0
36respiratory failure10.0
37sarcoidosis10.0
38tsc1-related lymphangioleiomyomatosis10.0
39lymphangioleiomyomatosis, somatic10.0
40kidney rhabdoid cancer10.0TSC2
41thyroid cancer10.0VEGFC
42kidney cancer10.0MTOR
43esophagitis10.0CCL26
44sertoli-leydig cell tumor10.0PGR
45cystadenoma10.0VEGFC
46syringoma10.0S100A1
47tuberous sclerosis complex10.0TSC2, TSC1
48glaucoma10.0MMP1
49fasciitis10.0ACTC1
50bladder carcinoma10.0TSC1

Graphical network of the top 20 diseases related to Lymphangioleiomyomatosis:



Diseases related to lymphangioleiomyomatosis

Clinical Features for Lymphangioleiomyomatosis

About this section
Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

606690

Symptoms:

48 (show all 36)
  • abnormal colour of the urine/cholic/dark urines
  • polycystic kidneys
  • lymphedema
  • cutaneous neurofibromas/facial angiofibromas/koenen tumors
  • hydrocephaly
  • seizures/epilepsy/absences/spasms/status epilepticus
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • kidney/renal neoplasm/tumor/carcinoma/cancer
  • fever/chilling
  • asthenia/fatigue/weakness
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • repeat respiratory infections
  • lymphadenopathy/polyadenopathies
  • atelectasia/pulmonary collapse
  • emphysema
  • acute abdominal pain/colic
  • ungual/paraungual fibromas (fingernails)
  • anomalies of the lymphatic system
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • cough
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • thoracic/chest pain
  • multicystic kidney/renal dysplasia
  • hematuria/microhematuria
  • uterine/uterus/fallopian tubes anomalies
  • hemoptysis
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • ascitis
  • abnormal pigmentary skin changes/skin pigmentation anomalies
  • macules
  • shagreen patch
  • anomalies of eyelids, eyelashes and lacrimal system
  • optic nerve anomaly/optic atrophy/anomaly of the papilla
  • retinal hamartoma
  • lung/pulmonary infiltrates

Drugs & Therapeutics for Lymphangioleiomyomatosis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lymphangioleiomyomatosis

Drug clinical trials:

Search ClinicalTrials for Lymphangioleiomyomatosis

Search NIH Clinical Center for Lymphangioleiomyomatosis

Search CenterWatch for Lymphangioleiomyomatosis

Genetic Tests for Lymphangioleiomyomatosis

About this section
Sources:
22GTR
See all sources

Genetic tests related to Lymphangioleiomyomatosis:

id Genetic test Affiliating Genes
1 Lymphangiomyomatosis22

Anatomical Context for Lymphangioleiomyomatosis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Lymphangioleiomyomatosis:

32
Lung, Kidney, Smooth muscle, Lymph node, Liver, Brain, Skin, Uterus, Endothelial, Testes, T cells, Heart, Bone, Colon, Thyroid

Animal Models for Lymphangioleiomyomatosis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Lymphangioleiomyomatosis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.3IGF1R, MMP2, ACTC1, SRF, ESR1, TSC1
2MP:000200610.1IGF1R, FIGF, PGR, MMP2, ESR1, TSC1
3MP:000539010.0MTOR, IGF1R, PGR, SRF, TSC1
4MP:000538010.0TSC2, TSC1, ESR1, SRF, PGR, IGF1R
5MP:000537610.0PMEL, MTOR, DES, IGF1R, PGR, ACTC1
6MP:00028739.9S100A1, MTOR, RHEBL1, FIGF, PGR, MMP2
7MP:00030129.9PMEL, MLANA, MTOR, RHEBL1, PGR, SRF
8MP:00107719.9PMEL, IGF1R, TSC1, TSC2
9MP:00053859.9TSC2, S100A1, DES, VEGFC, IGF1R, FIGF
10MP:00053869.8S100A1, MTOR, DES, IGF1R, FIGF, PGR
11MP:00107689.7FIGF, IGF1R, VEGFC, DES, RHEBL1, MTOR

Publications for Lymphangioleiomyomatosis

About this section
Sources:
50PubMed
See all sources

Articles related to Lymphangioleiomyomatosis:

(show top 50)    (show all 509)
idTitleAuthorsYear
1
Doxycycline use in patients with lymphangioleiomyomatosis: biomarkers and pulmonary function response. (23503480)
2013
2
Pulmonary Lymphangioleiomyomatosis: A Rare Case. (24101355)
2013
3
Serum VEGF-D concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial. (24159565)
2013
4
Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis. (23526212)
2013
5
Distinguishing between lymphangioleiomyomatosis and carcinomatous peritonitis in a patient with ovarian cancer. (23752115)
2013
6
Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis. (23224417)
2012
7
Pulmonary lymphangioleiomyomatosis associated with retroperitoneal lymphangioleiomyomas. (22665867)
2012
8
Efficacy and safety of sirolimus in lymphangioleiomyomatosis. (21410393)
2011
9
Prevalence of uterine leiomyomas in lymphangioleiomyomatosis. (21880281)
2011
10
Pulmonary arterial involvement leading to alveolar hemorrhage in lymphangioleiomyomatosis. (21876992)
2011
11
Lymphangioleiomyomatosis: what do we know and what are we looking for? (21357890)
2011
12
Chordoid meningioma in a patient with lymphangioleiomyomatosis. (21643986)
2011
13
Phenotypic characterization of disseminated cells with TSC2 loss of heterozygosity in patients with lymphangioleiomyomatosis. (20639436)
2010
14
Molecular pathology of lymphangioleiomyomatosis and other perivascular epithelioid cell tumors. (20073603)
2010
15
The natural history of lymphangioleiomyomatosis: markers of severity, rate of progression and prognosis. (20235883)
2010
16
mTOR signaling in lymphangioleiomyomatosis. (20235885)
2010
17
Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases. (20382711)
2010
18
Lymphangioleiomyomatosis: cause of a malignant chylous pleural effusion. (19901112)
2010
19
Involvement of lymphatics in lymphangioleiomyomatosis. (20143921)
2009
20
Successful factor XIII administration for persistent chylothorax after lung transplantation for lymphangioleiomyomatosis. (19699944)
2009
21
Malignant epithelioid angiomyolipoma in the kidney and liver of a patient with pulmonary lymphangioleiomyomatosis: lack of response to sirolimus. (19834275)
2009
22
Tuberous sclerosis with pulmonary lymphangioleiomyomatosis and renal angiomyolipomas. Computed tomographic findings: a case report. (20062701)
2009
23
Melanoma-associated antigen expression in lymphangioleiomyomatosis renders tumor cells susceptible to cytotoxic T cells. (19893037)
2009
24
Urinary bladder leiomyoma associated with pulmonary lymphangioleiomyomatosis. (18313110)
2008
25
Lymphangioleiomyomatosis-related spontaneous pneumothorax in a young woman. (19186570)
2008
26
Air travel in women with lymphangioleiomyomatosis. (17040934)
2007
27
Genetic and morphologic determinants of pneumothorax in lymphangioleiomyomatosis. (17616646)
2007
28
A case of lymphangioleiomyomatosis affecting the supraclavicular lymph nodes. (16628048)
2006
29
Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas. (16575396)
2006
30
Lymphangiogenesis-mediated shedding of LAM cell clusters as a mechanism for dissemination in lymphangioleiomyomatosis. (16160479)
2005
31
Abdominal lymphangioleiomyomatosis in a man with Klinefelter syndrome: the first reported case. (15806517)
2005
32
Lymphangioleiomyomatosis: a case report and review of the literature. (15656345)
2004
33
Transforming growth factor-beta 1 and extracellular matrix-associated fibronectin expression in pulmonary lymphangioleiomyomatosis. (15006970)
2004
34
Acute respiratory failure with gross hemoptysis in a patient with lymphangioleiomyomatosis as part of tuberous sclerosis complex. (15468981)
2004
35
A case of pulmonary lymphangioleiomyomatosis. (14649111)
2003
36
Lymphangioleiomyomatosis: pulmonary and abdominal findings with pathologic correlation. (12376610)
2002
37
Distribution and mRNA expression of insulin-like growth factor system in pulmonary lymphangioleiomyomatosis. (11523698)
2001
38
Mutational analysis of the tuberous sclerosis gene TSC2 in patients with pulmonary lymphangioleiomyomatosis. (10633137)
2000
39
Lymphangioleiomyomatosis (LAM): a review of clinical and morphological features. (11031360)
2000
40
Renal and pulmonary lymphangioleiomyomatosis: a case report. (11091010)
2000
41
Markers of cell proliferation and expression of melanosomal antigen in lymphangioleiomyomatosis. (10460750)
1999
42
Rare diseases. 1. Lymphangioleiomyomatosis: clinical features, management and basic mechanisms. (10325903)
1999
43
Pulmonary lymphangioleiomyomatosis. A study of 69 patients. Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P). (10499073)
1999
44
Retroperitoneal lymphangioleiomyomatosis: CT appearance. (9510588)
1998
45
Lymphangioleiomyomatosis: new insights. (9279258)
1997
46
Pregnancy exacerbating unsuspected mediastinal lymphangioleiomyomatosis and chylothorax. (8775689)
1996
47
Extrapulmonary lymphangioleiomyomatosis and lymphangiomatous cysts in tuberous sclerosis complex. (7791386)
1995
48
Pulmonary lymphangioleiomyomatosis in postmenopausal women: report of two cases and review of the literature. (8050534)
1994
49
Intrathoracic lymphangiomatosis mimicking lymphangioleiomyomatosis in a young woman. (2593716)
1989
50
Efficacy of oophorectomy in lymphangioleiomyomatosis and benign metastasizing leiomyoma. (7242600)
1981

Genetic Variations for Lymphangioleiomyomatosis

About this section
Sources:
62UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Lymphangioleiomyomatosis:

62
id Symbol AA change Variation ID SNP ID
1TSC2p.Arg611GlnVAR_005650

Expression for genes affiliated with Lymphangioleiomyomatosis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphangioleiomyomatosis

Search GEO for disease gene expression data for Lymphangioleiomyomatosis.

Pathways for genes affiliated with Lymphangioleiomyomatosis

About this section
Sources:
51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 52R&D Systems
See all sources

Pathways related to Lymphangioleiomyomatosis according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4IGF1R
210.4TSC2, TSC1
3
Hide members
10.3FIGF, VEGFC
410.3MTOR, TSC1, TSC2
5
Hide members
10.3TSC2, TSC1, MTOR
610.3TSC2, TSC1, MTOR
710.3TSC2, TSC1, IGF1R
8
Cell adhesion ECM remodeling
Hide members
10.3MMP1, MMP2, IGF1R
910.3IGF1R, MMP2, ESR1
10
Hide members
10.2TSC2, TSC1, MMP1, MTOR
1110.2MTOR, ESR1, TSC1, TSC2
12
Translation Insulin regulation of translation
Hide members
10.2MTOR, IGF1R, TSC1, TSC2
13
Hide members
10.2TSC2, TSC1, IGF1R, MTOR
14
Hide members
10.2MTOR, IGF1R, TSC1, TSC2
15
Hide members
10.2TSC2, TSC1, IGF1R, MTOR
1610.2MTOR, IGF1R, TSC1, TSC2
17
Hide members
10.2MTOR, PGR, ESR1, TSC2
18
Development Endothelin-1/EDNRA signaling
Hide members
10.2TSC2, ESR1, MMP2, MTOR
19
Transcription Androgen Receptor nuclear signaling
Hide members
10.2MTOR, IGF1R, MMP2, TSC2
20
Hide members
10.2TSC2, TSC1, FIGF, VEGFC
2110.2MTOR, IGF1R, MMP2, ESR1
2210.2MTOR, MMP1, ESR1, TSC1, TSC2
2310.1MTOR, IGF1R, SRF, TSC1, TSC2
2410.1MTOR, VEGFC, IGF1R, FIGF, TSC1, TSC2
25
Hide members
10.1CCL26, VEGFC, IGF1R, FIGF, TSC1, TSC2
2610.1MTOR, VEGFC, IGF1R, FIGF, MMP2, MMP1
27
Hide members
10.0VEGFC, IGF1R, FIGF, MMP2, MMP1, SRF
28
Hide members
9.9MTOR, RHOD, VEGFC, IGF1R, FIGF, PGR
29
Hide members
9.9CCL26, DES, VEGFC, IGF1R, FIGF, SRF

Compounds for genes affiliated with Lymphangioleiomyomatosis

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Lymphangioleiomyomatosis according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1matrigel4410.6RHOD, MTOR, ACTC1, MMP1
2alendronate44 49 1112.6ESR1, MMP1, MMP2, RHOD
3trastuzumab44 49 1112.6PGR, ESR1, VEGFC, IGF1R
4glycogen44 2411.6IGF1R, MTOR, TSC1, TSC2, ACTC1
5progestin4410.6DES, PGR, ESR1, MMP1, IGF1R
6mucicarmine4410.5S100A1, DES, ACTC1
7actomyosin4410.5S100A1, ACTC1, SRF, RHOD
8vitamin a44 11 2412.5MMP1, MMP2, SRF, IGF1R
9lapatinib44 49 1112.5IGF1R, PGR, ESR1
10resveratrol44 59 11 2413.5ESR1, PGR, MTOR, IGF1R, MMP2
11dexamethasone44 49 28 1113.5SRF, IGF1R, MTOR, VEGFC
12dihydrotestosterone44 28 11 2413.5SRF, ESR1, DES, IGF1R, PGR
13pge24410.5IGF1R, VEGFC, RHOD, MMP2
14hematoxylin4410.5MMP1, ACTC1, MLANA, S100A1, DES
15creatinine4410.5ACTC1, MMP2, IGF1R, MMP1, SRF
16clomiphene citrate4410.5ESR1, PGR, IGF1R
17gefitinib44 49 1112.5MTOR, IGF1R, MMP2, ESR1
185fluorouracil4410.5SRF, MMP2, MTOR, IGF1R, PGR, ESR1
19ribonucleic acid4410.5ACTC1, MMP1, VEGFC, MMP2, PGR, IGF1R
20tibolone4410.5PGR, MMP1, ESR1
21methotrexate44 49 1112.5ESR1, SRF, MMP1, MMP2, PGR
22daidzein4410.5IGF1R, ESR1, SRF
23steroid4410.4ACTC1, TSC2, MLANA, MTOR, DES, ESR1
24doxorubicin44 49 1112.4MMP1, IGF1R, DES, MTOR, PGR, ESR1
25rapamycin4410.4MTOR, IGF1R, TSC2, TSC1, MMP1, CCL26
26pd 98,0594410.4TSC1, MTOR, RHOD, VEGFC, IGF1R, MMP2
27phxa 854410.4MMP1, MMP2
28ly2940024410.4MTOR, RHOD, VEGFC, IGF1R, MMP2, TSC2
29glucose4410.4TSC1, SRF, ACTC1, IGF1R, VEGFC, TSC2
30estradiol44 11 2412.4SRF, MTOR, DES, VEGFC, IGF1R, PGR
31Ethynodiol Diacetate1110.3ESR1, PGR
32genistein44 28 59 2 11 2415.3SRF, PGR, IGF1R, ESR1, MMP1, MMP2
33lactate4410.3IGF1R, MMP2, MMP1, MLANA, DES, SRF
34phosphatidylinositol4410.3TSC2, TSC1, SRF, MMP2, IGF1R, VEGFC
3512-o-tetradecanoylphorbol 13-acetate4410.3DES, MMP2, MTOR, MMP1, SRF
36levonorgestrel44 59 28 1113.3PGR, MMP1, ESR1
37serine4410.3MMP1, MMP2, DES, TSC2, SRF, TSC1
38cysteine4410.2CCL26, S100A1, IGF1R, PGR, RHOD, MMP1
39ici 1643844410.2PGR, ESR1
40threonine4410.2MTOR, RHOD, DES, TSC2, TSC1, SRF
41tamoxifen44 49 28 1113.2IGF1R, ESR1, MTOR, FIGF, PGR
42testosterone44 59 11 2413.2MTOR, DES, MMP2, ACTC1, IGF1R, SRF
43oxygen44 2411.2RHOD, TSC2, SRF, ACTC1, VEGFC, DES
44retinoic acid44 2411.1ESR1, SRF, MTOR, DES, VEGFC, IGF1R
45progesterone44 59 28 11 2414.1S100A1, DES, ESR1, SRF, ACTC1, MMP1
46paraffin4410.1IGF1R, ESR1, TSC2, TSC1, MMP1, MMP2
47tyrosine4410.0S100A1, MTOR, RHOD, DES, IGF1R, FIGF
48calcium44 49 11 2413.0IGF1R, MMP1, VEGFC, ACTC1, DES, RHOD
49taxane4410.0PGR, MTOR, ESR1
50vegf4410.0FIGF, IGF1R, VEGFC, DES, RHOD, MTOR

GO Terms for genes affiliated with Lymphangioleiomyomatosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Lymphangioleiomyomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TSC1-TSC2 complexGO:03359610.4TSC2, TSC1
2membraneGO:0160209.7TSC2, TSC1, ESR1, FIGF, IGF1R, VEGFC

Biological processes related to Lymphangioleiomyomatosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell sizeGO:04579210.5TSC2, TSC1, MTOR
2positive chemotaxisGO:05091810.4TSC2, FIGF, VEGFC
3positive regulation of mast cell chemotaxisGO:06075410.4FIGF, VEGFC
4insulin receptor signaling pathwayGO:00828610.4MTOR, IGF1R, TSC1, TSC2
5protein heterooligomerizationGO:05129110.4IGF1R, TSC1, TSC2
6insulin-like growth factor receptor signaling pathwayGO:04800910.3TSC2, IGF1R
7cardiac myofibril assemblyGO:05500310.2SRF, ACTC1
8signal transductionGO:00716510.1CCL26, MTOR, VEGFC, IGF1R, PGR, ESR1
9TOR signaling cascadeGO:03192910.0RHEBL1, MTOR

Molecular functions related to Lymphangioleiomyomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor receptor 3 bindingGO:04318510.0FIGF, VEGFC
2protein bindingGO:0055159.5S100A1, MLANA, MTOR, DES, VEGFC, IGF1R

Products for genes affiliated with Lymphangioleiomyomatosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphangioleiomyomatosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet