MCID: LYM022
MIFTS: 57

Lymphangioma malady

Cancer diseases, Immune diseases categories

Summaries for Lymphangioma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Lymphangiomas are malformations of the lymphatic system, which is the network of vessels responsible for... more...

MalaCards: Lymphangioma, also known as lymphangioma of unspecified site, is related to cystic lymphangioma and hemangioma. An important gene associated with Lymphangioma is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are Signaling by VEGF and Presynaptic nicotinic acetylcholine receptors. The compounds galantamine and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include pancreas, tongue and spleen, and related mouse phenotypes are respiratory system and muscle.

Aliases & Classifications for Lymphangioma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

lymphangioma 8 42 10 44 60
lymphangioma of unspecified site 8
lymphangioma, no icd-o subtype 8
congenital lymphangioma 8
lymphangioma, any site 8
benign lymphangioma 8
lymphangioma nos 8
lymphangiomas 42


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Disease Ontology8 DOID:1475
MeSH34 D008202
NCIt39 C8965
ICD9CM27 228.1
ICD1025 D18.1

Related Diseases for Lymphangioma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lymphangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1cystic lymphangioma31.6AFP, CHRNG, CHRND, MAST4, HIRA, EIF3M
2hemangioma30.3PDPN, FLT4, PROX1, CD34, ACTC1, PECAM1
3sarcoma30.2PECAM1, ACTC1, CD34, FLT4
4kaposi's sarcoma30.1CD34
5lymphangiosarcoma29.9PROX1
6melanoma29.9PDPN, FLT4, VEGFC, CD34, ACTC1, PTCH1
7peritonitis29.7PECAM1
8capillary hemangioma29.7CD34
9hydrocele29.7FLT4
10epithelioid hemangioendothelioma29.7FLT4, CD34
11seminoma29.7PDPN, FLT4, AFP, VEGFC
12glioblastoma multiforme29.7PECAM1, PTCH1, VEGFC, FLT4, PDPN
13breast cancer29.7LYVE1, PECAM1, PTCH1, ACTC1, VEGFC, FLT4
14squamous cell carcinoma29.7PDPN, FLT4, VEGFC, CD34, ACTC1, PTCH1
15mediastinitis10.5
16colonic lymphangioma10.5
17pancreatitis10.5
18cervicitis10.4
19abdominal cystic lymphangioma10.3
20hepatitis10.3
21microcystic lymphatic malformation10.2
22macrocystic lymphatic malformation10.2
23capillary lymphangioma10.2
24hepatitis a10.2
25diffuse lymphatic malformation10.2
26klippel-trenaunay syndrome10.1
27intussusception10.1
28appendicitis10.1
29adenomatoid tumor10.1
30cavernous lymphangioma10.1
31lymphatic malformation10.1
32tonsillitis10.1
33esophagitis10.1
34laryngitis10.1
35thyroiditis10.1
36hygroma cervical10.1
37orbital lymphangioma10.1
38circumscribed lymphatic malformation10.1
39hemangioblastoma10.0PDPN
40fetal akinesia deformation sequence10.0RAPSN
41oligohydramnios10.0AFP
42nicotine dependence10.0CHRNB1
43adenoma10.0ACTC1, FLT4
44hemangioendothelioma10.0CD34, FLT4
45multiple pterygium syndrome lethal type10.0CHRNG, CHRND
46malignant mesothelioma10.0FLT4, PDPN
47slow-channel congenital myasthenic syndrome10.0CHRND, CHRNB1
48congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.0CHRNB1, RAPSN
49spindle cell sarcoma10.0FLT4, ACTC1
50gallbladder cancer10.0PDPN

Graphical network of the top 20 diseases related to Lymphangioma:



Diseases related to lymphangioma

Clinical Features for Lymphangioma

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Drugs & Therapeutics for Lymphangioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lymphangioma

Drug clinical trials:

Search ClinicalTrials for Lymphangioma

Search NIH Clinical Center for Lymphangioma

Search CenterWatch for Lymphangioma

Genetic Tests for Lymphangioma

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Anatomical Context for Lymphangioma

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32MalaCards
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MalaCards organs/tissues related to Lymphangioma:

32
Pancreas, Tongue, Spleen, Colon, Breast, Endothelial, Adrenal gland, Skin, Ovary, Tonsil, Thyroid, Bone, Kidney, Lung, Uterus, Heart, Cervix, Prostate, Liver, Small intestine, Retina, Lymph node, B cells, T cells, Testis

Animal Models for Lymphangioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lymphangioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.4PROX1, CHRNG, RAPSN, PTCH1, PECAM1, PDPN
2MP:00053699.4PDPN, FLT4, CHRNG, RAPSN, ACTC1, PTCH1
3MP:00053858.7LYVE1, PDPN, FLT4, PROX1, VEZF1, VEGFC
4MP:00053878.5PDPN, FLT4, PROX1, VEZF1, VEGFC, HIRA
5MP:00107688.4PDPN, FLT4, PROX1, AFP, CHRNG, VEZF1
6MP:00053768.3AFP, PROX1, FLT4, PDPN, CHRNG, VEGFC

Publications for Lymphangioma

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50PubMed
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Articles related to Lymphangioma:

(show top 50)    (show all 818)
idTitleAuthorsYear
1
A rapidly growing neck mass in childhood: Castleman's disease concomitant with cavernous lymphangioma in the posterior cervical region. (23682944)
2013
2
A new operative strategy for refractory microcystic lymphangioma. (24292654)
2013
3
Mediastinal Hodgkin lymphoma arising from cystic lymphangioma: case report in a child. (23094543)
2012
4
F-18 FDG uptake in a retroperitoneal cystic lymphangioma mimicking malignancy. (22614215)
2012
5
Education and Imaging. Gastrointestinal: small bowel lymphangioma diagnosed by single-balloon enteroscopy. (22823918)
2012
6
Lymphangioma circumscriptum of the vulva: a rare case report. (22901902)
2012
7
Adult lymphangioma - a rare entity: a report of two cases. (22207438)
2012
8
Large lymphangioma presenting like irreducible inguinal hernia: a rare presentation and literature review. (22206072)
2011
9
Kaposiform hemangioendothelioma in tonsil of a child associated with cervical lymphangioma: a rare case report. (21605441)
2011
10
An unusual cause of acute abdomen in adults: giant cystic lymphangioma of the pancreatic head. A clinical case and literature review. (21546706)
2011
11
Lymphangioma of the tongue. (22442618)
2011
12
Giant pericardial lymphangioma--imaging, surgical, and pathologic correlations. (21926863)
2011
13
Pancreatic cystic lymphangioma in a 6-year-old girl, diagnosed by endoscopic ultrasound (EUS) fine needle aspiration. (21287455)
2011
14
Isolation and characterization of lymphatic endothelial cells from human glossal lymphangioma. (19956870)
2010
15
Image of the month--quiz case. Abdominal lymphangioma. (20231635)
2010
16
Surgery as the treatment of choice in vulvar lymphangioma circumscriptum: case report and review of other management options. (20580481)
2010
17
Cystic Lymphangioma of the Breast: Magnetic Resonance Imaging Features. (22590445)
2010
18
Giant cystic lymphangioma of the liver. (21286352)
2010
19
Microcystic lymphatic malformation (lymphangioma circumscriptum) treated using a minimally invasive technique of radiofrequency ablation and sclerotherapy. (20961352)
2010
20
Lymphangioma of the ovary accompanied by chylous ascites. (19751350)
2009
21
Congenital orbital lymphangioma in a 20-years old girl a case report and review of literature. (21483541)
2009
22
Asymptomatic lymphangioma involving the spleen and retroperitoneum in adults. (19938204)
2009
23
Diagnosis of cystic lymphangioma of the pancreas with endoscopic ultrasound-guided fine needle aspiration. (18397437)
2008
24
Small intestinal B-cell lymphoma in a patient with lymphangiectasia secondary to abdominal lymphangioma. (18235129)
2008
25
Treatment of lymphangioma in children: our experience of 128 cases. (17270554)
2007
26
Lymphangioma circumscriptum of the penis: a case report. (17992464)
2007
27
Spontaneous regression of a cystic tumor in a postpartum woman; is it a cystic lymphangioma? (17722248)
2007
28
Intra-abdominal lymphangioma: usefulness of endoscopic ultrasound and laparoscopy in diagnosis. (16460504)
2006
29
Cystic lymphangioma of the small bowel in a woman at 15 weeks' gestation: laparoscopic approach. (16082316)
2005
30
Cystic lymphangioma of the colon: endosonographic diagnosis with through-the-scope catheter miniprobe and determination of further management. Report of a case. (11496086)
2001
31
Excision of cervical cystic lymphangioma using injection of hydrocolloid dental impression material. A technical case report. (10416899)
1999
32
Cystic lymphangioma of the pancreas: CT and pathologic findings. (9437068)
1998
33
Cystic lymphangioma of the spleen mimicking hydatid disease. (9649019)
1998
34
Generalized lymphangiomatosis with chylothorax and skin lymphangiomas in a neonate. (9720697)
1998
35
Mediastinal cystic lymphangioma: report of two cases. (9323827)
1997
36
Klippel-Trenaunay-Weber syndrome associated with intra-abdominal lymphangioma requiring multiple surgical interventions. (9339289)
1997
37
Retroperitoneal cystic lymphangioma diagnosed by computerized tomography, magnetic resonance imaging and thin needle aspiration. (8738615)
1996
38
Cystic lymphangioma of the colon: ultrasonographic and computed tomographic features. (7704677)
1995
39
Case report: giant tuberculous cystic lymphangioma of posterior mediastinum, retroperitoneum and groin. (8143418)
1994
40
Retroperitoneal cystic lymphangioma section imaging in two cases, and review of the literature. (2182185)
1990
41
Two cases of cystic lymphangioma in the neck region in adults. (7144246)
1982
42
Retroperitoneal cystic lymphangioma. (7127011)
1982
43
A pediatric case of cystic lymphangioma of the spleen. (7240529)
1981
44
Sonographic diagnosis of a cystic lymphangioma in utero. Effect on obstetric management. (7205813)
1981
45
Cystic lymphangioma of the cecum with ileocecal intussusception: Case report. (1163907)
1975
46
Cavernous lymphangioma in a 20-day-old child. (1150317)
1975
47
A CASE OF CYSTIC LYMPHANGIOMA IN THE PELVIC MESOCOLON. (14263415)
1964
48
Case of Large Lymphangioma or Telangiectasis occupying the Lower Half of Left Abdomen and Left Leg. (19984860)
1926
49
Cystic Lymphangioma in Infant. (19979056)
1915
50
CYSTIC LYMPHANGIOMA OF THE GREAT OMENTUM. (17863276)
1914

Genetic Variations for Lymphangioma

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Expression for genes affiliated with Lymphangioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphangioma

Search GEO for disease gene expression data for Lymphangioma.

Pathways for genes affiliated with Lymphangioma

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53Reactome, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN
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Compounds for genes affiliated with Lymphangioma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Lymphangioma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1galantamine44 49 1112.3CHRNB1, CHRND, CHRNG
2sialic acid4410.3PECAM1
3b 7234410.2PDPN, AFP, ACTC1
4p0054410.1AFP, PECAM1, LYVE1
5matrigel4410.0PECAM1, ACTC1, VEGFC, FLT4
6hematoxylin4410.0PDPN, CD34, ACTC1, PECAM1
7glycosaminoglycan449.8LYVE1, PECAM1, ACTC1
8reticulin449.8ACTC1, CD34
9thymidine44 2410.6AFP, VEGFC, CD34, PECAM1, LYVE1
10progesterone44 59 28 11 2413.5AFP, VEGFC, CD34, ACTC1, LYVE1
11retinoic acid44 2410.5FLT4, AFP, VEGFC, CD34, ACTC1, PECAM1
12estrogen449.4FLT4, AFP, VEGFC, CD34, ACTC1, PECAM1
13tyrosine449.2PDPN, FLT4, AFP, VEGFC, CD34, RAPSN
14paraffin449.1LYVE1, PDPN, FLT4, AFP, VEGFC, CD34
15vegf449.1PDPN, FLT4, PROX1, AFP, VEGFC, CD34

GO Terms for genes affiliated with Lymphangioma

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16Gene Ontology
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Cellular components related to Lymphangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.1CHRNB1, CHRND, CHRNG
2postsynaptic membraneGO:0452119.8CHRNG, RAPSN, CHRNB1, CHRND
3cell junctionGO:0300549.7CHRNB1, CHRNG, CHRND, PECAM1, RAPSN
4integral to plasma membraneGO:0058879.4CHRNG, LYVE1, CD34, PDPN, CHRNB1, FLT4
5plasma membraneGO:0058868.4LYVE1, FLT4, PECAM1, PTCH1, RAPSN, CD34

Biological processes related to Lymphangioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:00727110.2RAPSN, CHRNB1
2glomerular endothelium developmentGO:07201110.1PECAM1, CD34
3lymphangiogenesisGO:00194610.1PROX1, FLT4, PDPN
4skeletal muscle thin filament assemblyGO:03024010.1ACTC1, PROX1
5regulation of membrane potentialGO:04239110.0CHRNG, CHRND, CHRNB1
6transportGO:0068109.8AFP, CHRNG, CHRND, CLIC2, LYVE1
7muscle contractionGO:0069369.8CHRNB1, CHRND, CHRNG
8signal transductionGO:0071659.3PDPN, CHRNG, CHRND, CHRNB1, VEGFC, CD34

Molecular functions related to Lymphangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine receptor activityGO:01546410.2CHRNB1, CHRNG
2channel activityGO:01526710.1CHRNB1, CHRNG
3acetylcholine-activated cation-selective channel activityGO:00488910.1CHRNB1, CHRND, CHRNG
4acetylcholine bindingGO:0421669.9CHRNB1, CHRND

Products for genes affiliated with Lymphangioma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphangioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet