MCID: LYM022
MIFTS: 52

Lymphangioma malady

Categories: Rare diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Lymphangioma

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Aliases & Descriptions for Lymphangioma:

Name: Lymphangioma 10 45 47 12 36 65
Congenital Lymphangioma 10
 
Benign Lymphangioma 10
Lymphangiomas 45

Classifications:



External Ids:

Disease Ontology10 DOID:1475
ICD1027 D18.1
ICD9CM29 228.1
MeSH36 D008202
NCIt42 C8965
UMLS65 C0024221

Summaries for Lymphangioma

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NIH Rare Diseases:45 Lymphangioma is a benign (non-cancerous) mass made of fluid-filled spaces, which is thought to occur due to abnormal development of the lymphatic system. they are always present at birth, although they may change and become more apparent over time. lymphangiomas are most commonly found in the head and neck region, but can affect almost any part of the body (except the brain). some may appear as a tiny blue or red spot while others are massive and affect an entire limb (arm or leg). the signs and symptoms vary depending on the size and location of the mass; however, lymphangiomas can disfigure affected areas and potentially disrupt the function of nearby organs or tissues regardless of size. the exact underlying cause is unknown. treatment options vary based on the signs and symptoms present in each person but may include surgery. last updated: 12/20/2014

MalaCards based summary: Lymphangioma, also known as congenital lymphangioma, is related to cavernous hemangioma and hemangioma thrombocytopenia syndrome, and has symptoms including pain of lymph node An important gene associated with Lymphangioma is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways are VEGF ligand-receptor interactions and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include brain, breast and lymph node, and related mouse phenotypes are digestive/alimentary and muscle.

Wikipedia:68 Lymphangiomas are malformations of the lymphatic system characterized by lesions that are thin-walled... more...

Related Diseases for Lymphangioma

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Diseases related to Lymphangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1cavernous hemangioma30.8EGFR, PIK3CA
2hemangioma thrombocytopenia syndrome30.2FLT4, PROX1
3cystic lymphangioma12.3
4capillary lymphangioma12.1
5abdominal cystic lymphangioma12.1
6cavernous lymphangioma12.1
7colonic lymphangioma12.1
8orbital lymphangioma12.0
9primary laryngeal lymphangioma12.0
10macrocystic lymphatic malformation11.8
11microcystic lymphatic malformation11.7
12circumscribed lymphatic malformation11.2
13diffuse lymphatic malformation11.1
14congenital megalo-ureter10.6FLT4, VEGFC
15hemangioma10.6
16myoepithelial carcinoma10.6FLT4, IFNA2
17hypospadias-hypertelorism-coloboma and deafness syndrome10.5FLT4, IFNA2
18red cell phospholipid defect with hemolysis10.4EGFR, IFNG
19cobb syndrome10.4
20vascular malformation10.4
21cervical non-keratinizing squamous cell carcinoma10.4EGFR, PIK3CA
22mediastinitis10.3
23eccrine papillary adenocarcinoma10.3EGFR, PIK3CA
24soft tissue sarcoma childhood10.3EGFR, IFNG
25polyneuropathy in collagen vascular disease10.3EGFR, PIK3CA
26transient tic disorder10.3EGFR, PIK3CA
27anterior horn cell disease10.3EGFR, PIK3CA
28early-onset, autosomal dominant alzheimer disease10.3IFNG, SERPINF1
29peritoneal cystic mesothelioma10.3EGFR, IFNG
30kaposiform hemangioendothelioma10.3
31pancreatitis10.3
32intracranial hemorrhage in brain cerebrovascular malformations10.3FLT4, IFNA2, VEGFC
33reticulosarcoma10.3IFNA2, IFNG
34prostatic urethra urothelial carcinoma10.3EGFR, PIK3CA
35uterine carcinosarcoma10.2PIK3CA, VEGFC
36familial short qt syndrome10.2EGFR, IFNA2
37gastric cardia carcinoma10.2EGFR, PROX1
38cervicitis10.2
39ehrlich tumor carcinoma10.1FLT4, HBA1
40hepatitis10.1
41lymphangiomatosis10.1
42dyskeratosis congenita10.1FLT4, HBA1
43endotheliitis10.1
44pasteurellosis10.1EGFR, IFNA2, IFNG
45orofaciodigital syndrome iii10.0FLT4, PROX1, VEGFC
46lymphoblastic lymphoma10.0FLT4, PROX1, VEGFC
47tufted hair folliculitis10.0FLT4, IFNA2, PROX1
48zimmermann-laband syndrome 210.0EGFR, PIK3CA, VEGFC
49gallbladder leiomyosarcoma10.0HBA1, IFNA2
50sarcoma10.0

Comorbidity relations with Lymphangioma via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Lymphangioma:



Diseases related to lymphangioma

Symptoms for Lymphangioma

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UMLS symptoms related to Lymphangioma:


pain of lymph node

Drugs & Therapeutics for Lymphangioma

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Drugs for Lymphangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1PicibanilPhase 2, Phase 37
2Sildenafil CitratePhase 1, Phase 2304171599-83-0
3Vasodilator AgentsPhase 1, Phase 22926
4Phosphodiesterase InhibitorsPhase 1, Phase 21062
5Phosphodiesterase 5 InhibitorsPhase 1, Phase 2513
6CitrateNutraceuticalPhase 1, Phase 21001
7
Citric AcidnutraceuticalPhase 1, Phase 2100177-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
8
PancrelipaseapprovedPhase 088053608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
Creon
PA
Pancreatic alpha-amylase precursor
Pancreaze
 
Pancrelipase
Pertzye
Polocaine-mpf
Ultresa
Viokace
Zenpep
9pancreatinPhase 0880
10Anesthetics7385

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic MalformationsCompletedNCT00010452Phase 2, Phase 3
2A Study to Evaluate Sildenafil for the Treatment of Lymphatic MalformationsCompletedNCT01290484Phase 1, Phase 2
3AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome)RecruitingNCT02250456
4Needle-based Confocal Laser Endomicroscopy on Pancreatic Cystic LesionsRecruitingNCT02494388Phase 0
5Lymphatic Anomalies RegistryRecruitingNCT02399527
6Characterization of the Pathogenesis of Primary and Secondary Lymphatic DisordersRecruitingNCT02156115
7Imaging of Lymphatic AnomaliesEnrolling by invitationNCT02744027

Search NIH Clinical Center for Lymphangioma


Cochrane evidence based reviews: lymphangioma

Genetic Tests for Lymphangioma

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Anatomical Context for Lymphangioma

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MalaCards organs/tissues related to Lymphangioma:

33
Brain, Breast, Lymph node, Pancreas, Liver, Colon, Tongue

Animal Models for Lymphangioma or affiliated genes

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MGI Mouse Phenotypes related to Lymphangioma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5EGFR, FLT4, IFNG, PROX1, SERPINF1
2MP:00053698.0DOK7, EGFR, FLT4, IFNG, PIK3CA
3MP:00053857.2EGFR, FLT4, IFNG, PIK3CA, PROX1, SERPINF1

Publications for Lymphangioma

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Articles related to Lymphangioma:

(show top 50)    (show all 933)
idTitleAuthorsYear
1
Giant cystic lymphangioma originating from the cardia of the stomach: A case report. (27168832)
2016
2
Cystic Lymphangioma of Pancreas. (27065694)
2016
3
Lymphangioma Circumscriptum: Good Clinical Response to Isotretinoin Therapy. (27041148)
2016
4
Mesenteric lymphangioma mimicking a cystic ovarian mass on imaging. (26833955)
2016
5
Coexisting pancreatic mucinous cyst adenoma and adrenal lymphangioma. (25224209)
2014
6
Cystic lymphangioma of the chest wall: a case report. (25606029)
2014
7
Unusual sites of cystic lymphangioma in children. (25282458)
2014
8
Asymptomatic lymphangioma involving the spleen and mediastinum in adults. (23702506)
2013
9
Thoracic Cavernous Lymphangioma Provoking Massive Chyloptysis: A Case Report. (26425583)
2013
10
Lymphangioma circumscriptum of the tongue in children: successful treatment using intralesional bleomycin. (23732020)
2013
11
Complete Resolution of Retroperitoneal Lymphangioma with a Single Trial of OK-432 in an Infant. (24140312)
2013
12
Pericardial cystic lymphangioma. (23034994)
2013
13
Sildenafil for pediatric orbital lymphangioma. (23828510)
2013
14
Combined Mesothelial Cyst and Lymphangioma of the Small Bowel: A Distinct Hybrid Intra-Abdominal Cyst. (24220997)
2013
15
Splenic artery rupture during pregnancy concealed by a pancreatic lymphangioma: a rare co-occurrence. (23088804)
2013
16
Intestinal obstruction complicating a mesenteric cystic lymphangioma. (22795361)
2012
17
Mediastinal lymphangioma treated using endobronchial ultrasound-guided transbronchial needle aspiration. (23018866)
2012
18
Huge cystic lymphangioma of the pancreas mimicking pancreatic cystic neoplasm. (23197988)
2012
19
Robot-assisted laparoscopic removal of perirenal lymphangioma: a case report. (23210414)
2012
20
Lymphangioma: Is intralesional bleomycin sclerotherapy effective? (22279495)
2011
21
Cystic retroperitoneal lymphangioma. (20557520)
2010
22
Lymphangioma circumscriptum. (21048263)
2010
23
Anaesthetic consideration in macroglossia due to lymphangioma of tongue: a case report. (20640084)
2009
24
Solitary hepatic lymphangioma in a 22-day-old infant. (19635291)
2009
25
Vulvar lymphangioma circumscriptum. (19682682)
2009
26
Acquired progressive lymphangioma with atypical clinical presentation. (19171542)
2009
27
Giant lymphangioma of the tongue. (19165040)
2009
28
Lymphangioma circumscriptum of the tongue: successful treatment using intralesional bleomycin. (19545460)
2009
29
Cystic lymphangioma of the breast in a 6-year-old boy. (19853765)
2009
30
Haemorrhage in a scrotal lymphangioma in a child: a rarity. (19661642)
2009
31
Cystic lymphangioma of the gallbladder: report of a case. (18085372)
2008
32
Treatment of lymphangioma in children: our experience of 128 cases. (17270554)
2007
33
Cavernous mesenteric lymphangioma (2006: 4b). (16770656)
2006
34
Prenatal diagnosis of a fetal chest wall cystic lymphangioma using ultrasonography and MRI: a case report with literature review. (16260884)
2005
35
Orbital lymphangioma. (15234158)
2004
36
Abdominal cystic lymphangioma: a rare cause of acute abdomen in a neonate. (11737721)
2001
37
Giant cystic lymphangioma of the stomach. (11841086)
2001
38
Immunomodulatory treatment with low-dose interferon-alpha and oral retinoic acid in lymphangioma-like Kaposi's sarcoma. (10769722)
2000
39
Protein-loss into retroperitoneal lymphangioma: demonstration by lymphoscintigraphy and blood-pool scintigraphy with Tc-99m-human serum albumin. (10830532)
2000
40
Abdominal cystic lymphangioma in a woman at 14 weeks' gestation: case report. (11055491)
2000
41
Sotradecol (sodium tetradecyl sulfate) injection of orbital lymphangioma. (10588254)
1999
42
Mediastinal cystic lymphangioma: report of two cases. (9323827)
1997
43
Radiology/pathology conference: mesenteric cystic lymphangioma. (8692443)
1996
44
Abdominal cystic lymphangioma in children: benign lesions that can have a proliferative course. (8861480)
1996
45
Cystic lymphangioma of the transverse colon: report of a case and review of the literature. (8832861)
1996
46
Laparoscopic resection of a retroperitoneal cystic lymphangioma. (7878511)
1994
47
Case report: MRI and CT comparison of an orbital cavernous lymphangioma. (1753396)
1991
48
Sonographic appearance of an abdominal cystic lymphangioma. (6699930)
1984
49
CYSTIC LYMPHANGIOMA OF THE GREAT OMENTUM. (17863276)
1914
50

Variations for Lymphangioma

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Expression for genes affiliated with Lymphangioma

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Search GEO for disease gene expression data for Lymphangioma.

Pathways for genes affiliated with Lymphangioma

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Pathways related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.9FLT4, VEGFC
29.8EGFR, FLT4
39.4EGFR, PIK3CA
49.4EGFR, PIK3CA
59.4EGFR, PIK3CA
69.4EGFR, PIK3CA
7
Show member pathways
9.4EGFR, FLT4, VEGFC
89.4EGFR, PIK3CA
99.4EGFR, PIK3CA
109.3IFNG, PIK3CA
119.2FLT4, PIK3CA, VEGFC
12
Show member pathways
9.2FLT4, PIK3CA, VEGFC
139.2EGFR, IFNA2, IFNG
149.1HBA1, IFNG
159.1EGFR, IFNA2, PIK3CA
16
Show member pathways
9.0IFNA2, IFNG, PIK3CA
178.9EGFR, IFNG, PIK3CA
18
Show member pathways
8.8EGFR, FLT4, PIK3CA, VEGFC
19
Show member pathways
8.8EGFR, FLT4, PIK3CA, VEGFC
20
Show member pathways
8.8EGFR, FLT4, PIK3CA, VEGFC
218.4EGFR, FLT4, IFNA2, PIK3CA, VEGFC
22
Show member pathways
8.1EGFR, FLT4, IFNA2, IFNG, SERPINF1, VEGFC

GO Terms for genes affiliated with Lymphangioma

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Biological processes related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:003314110.2IFNA2, IFNG
2lymph vessel developmentGO:000194510.2FLT4, PROX1
3positive regulation of phosphorylationGO:004232710.0EGFR, IFNA2
4phosphatidylinositol phosphorylationGO:00468549.8EGFR, PIK3CA
5ERBB2 signaling pathwayGO:00381289.8EGFR, PIK3CA
6cellular response to glucose stimulusGO:00713339.6PIK3CA, SERPINF1
7positive regulation of cell proliferationGO:00082849.3FLT4, IFNG, PROX1
8negative regulation of cell proliferationGO:00082859.3IFNG, PROX1, VEGFC
9vascular endothelial growth factor receptor signaling pathwayGO:00480108.5EGFR, FLT4, PIK3CA, VEGFC

Sources for Lymphangioma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet