MCID: LYM022
MIFTS: 46

Lymphangioma malady

Categories: Rare diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Lymphangioma

About this section

Aliases & Descriptions for Lymphangioma:

Name: Lymphangioma 10 45 47 12 36 65
Congenital Lymphangioma 10
 
Benign Lymphangioma 10
Lymphangiomas 45

Classifications:



External Ids:

Disease Ontology10 DOID:1475
ICD1027 D18.1
ICD9CM29 228.1
MeSH36 D008202
NCIt42 C8965
UMLS65 C0024221

Summaries for Lymphangioma

About this section
NIH Rare Diseases:45 Lymphangioma is a benign (non-cancerous) mass made of fluid-filled spaces, which is thought to occur due to abnormal development of the lymphatic system. they are always present at birth, although they may change and become more apparent over time. lymphangiomas are most commonly found in the head and neck region, but can affect almost any part of the body (except the brain). some may appear as a tiny blue or red spot while others are massive and affect an entire limb (arm or leg). the signs and symptoms vary depending on the size and location of the mass; however, lymphangiomas can disfigure affected areas and potentially disrupt the function of nearby organs or tissues regardless of size. the exact underlying cause is unknown. treatment options vary based on the signs and symptoms present in each person but may include surgery. last updated: 12/20/2014

MalaCards based summary: Lymphangioma, also known as congenital lymphangioma, is related to hemangioma thrombocytopenia syndrome and cavernous hemangioma. An important gene associated with Lymphangioma is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways are VEGF ligand-receptor interactions and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include brain, lymph node and breast, and related mouse phenotypes are digestive/alimentary and muscle.

Wikipedia:68 Lymphangiomas are malformations of the lymphatic system characterized by lesions that are thin-walled... more...

Related Diseases for Lymphangioma

About this section

Diseases related to Lymphangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 605)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioma thrombocytopenia syndrome30.6FLT4, PROX1
2cavernous hemangioma30.5EGFR, PIK3CA
3lymphoblastic lymphoma29.9FLT4, PROX1, VEGFC
4hepatitis c virus29.8EGFR, IFNG, PIK3CA
5tufted hair folliculitis29.7FLT4, IFNA2, PROX1
6renal cell carcinoma29.3EGFR, FLT4, IFNA2, IFNG, PIK3CA
7colorectal cancer29.0EGFR, FLT4, IFNA2, IFNG, PIK3CA, VEGFC
8cystic lymphangioma12.5
9capillary lymphangioma12.4
10primary laryngeal lymphangioma12.4
11abdominal cystic lymphangioma12.4
12colonic lymphangioma12.3
13cavernous lymphangioma12.3
14orbital lymphangioma12.2
15macrocystic lymphatic malformation12.0
16microcystic lymphatic malformation11.9
17circumscribed lymphatic malformation11.6
18diffuse lymphatic malformation11.5
19hemangioma10.8
20epithelioid hemangioendothelioma10.6
21congenital megalo-ureter10.4FLT4, VEGFC
22myoepithelial carcinoma10.4FLT4, IFNA2
23breast cancer10.4
24cervicofacial lymphatic malformation10.3
25maffucci syndrome10.3
26cobb syndrome10.3
27fetal cystic hygroma10.3
28vascular malformation10.3
29endotheliitis10.3
30hypospadias-hypertelorism-coloboma and deafness syndrome10.3FLT4, IFNA2
31hepatitis10.3
32red cell phospholipid defect with hemolysis10.3EGFR, IFNG
33lymphoma10.3
34prostatitis10.3
35melanoma10.2
36cervical non-keratinizing squamous cell carcinoma10.2EGFR, PIK3CA
37eccrine papillary adenocarcinoma10.2EGFR, PIK3CA
38soft tissue sarcoma childhood10.2EGFR, IFNG
39polyneuropathy in collagen vascular disease10.2EGFR, PIK3CA
40transient tic disorder10.2EGFR, PIK3CA
41anterior horn cell disease10.2EGFR, PIK3CA
42early-onset, autosomal dominant alzheimer disease10.2IFNG, SERPINF1
43peritoneal cystic mesothelioma10.2EGFR, IFNG
44leukemia10.2
45cerebritis10.2
46glomus tumor10.2
47spindle cell hemangioma10.2
48angioma hereditary neurocutaneous10.2
49kaposiform hemangioendothelioma10.2
50non-involuting congenital hemangioma10.2

Graphical network of the top 20 diseases related to Lymphangioma:



Diseases related to lymphangioma

Symptoms for Lymphangioma

About this section

Drugs & Therapeutics for Lymphangioma

About this section

Drugs for Lymphangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1PicibanilPhase 2, Phase 37
2Sildenafil CitratePhase 1, Phase 2304171599-83-0
3Vasodilator AgentsPhase 1, Phase 22926
4Phosphodiesterase InhibitorsPhase 1, Phase 21062
5Phosphodiesterase 5 InhibitorsPhase 1, Phase 2513
6CitrateNutraceuticalPhase 1, Phase 21001
7
Citric AcidnutraceuticalPhase 1, Phase 2100177-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
8
PancrelipaseapprovedPhase 088053608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
Creon
PA
Pancreatic alpha-amylase precursor
Pancreaze
 
Pancrelipase
Pertzye
Polocaine-mpf
Ultresa
Viokace
Zenpep
9pancreatinPhase 0880
10Anesthetics7385

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic MalformationsCompletedNCT00010452Phase 2, Phase 3
2A Study to Evaluate Sildenafil for the Treatment of Lymphatic MalformationsCompletedNCT01290484Phase 1, Phase 2
3AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome)RecruitingNCT02250456
4Needle-based Confocal Laser Endomicroscopy on Pancreatic Cystic LesionsRecruitingNCT02494388Phase 0
5Lymphatic Anomalies RegistryRecruitingNCT02399527
6Characterization of the Pathogenesis of Primary and Secondary Lymphatic DisordersRecruitingNCT02156115
7Imaging of Lymphatic AnomaliesEnrolling by invitationNCT02744027

Search NIH Clinical Center for Lymphangioma


Cochrane evidence based reviews: lymphangioma

Genetic Tests for Lymphangioma

About this section

Anatomical Context for Lymphangioma

About this section

MalaCards organs/tissues related to Lymphangioma:

33
Brain, Lymph node, Breast, Endothelial, Bone, Liver, Prostate

Animal Models for Lymphangioma or affiliated genes

About this section

MGI Mouse Phenotypes related to Lymphangioma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5EGFR, FLT4, IFNG, PROX1, SERPINF1
2MP:00053698.0DOK7, EGFR, FLT4, IFNG, PIK3CA
3MP:00053857.2EGFR, FLT4, IFNG, PIK3CA, PROX1, SERPINF1

Publications for Lymphangioma

About this section

Articles related to Lymphangioma:

(show top 50)    (show all 904)
idTitleAuthorsYear
1
An rK28-Based Immunoenzymatic Assay for the Diagnosis of Canine Visceral Leishmaniasis in Latin America. (27162270)
2016
2
Corneal neovascularization and biological therapy. (26664467)
2015
3
Re: Cytoreductive Nephrectomy in Patients with Synchronous Metastases fromA Renal Cell Carcinoma: Results from the International Metastatic Renal CellA Carcinoma Database Consortium. (25895755)
2015
4
Adipose tissue-derived mesenchymal stem cells cultured at high density express IFN-I^ and suppress the growth of MCF-7 human breast cancer cells. (25016057)
2014
5
The role of local and systemic cytokines in patients infected with Clostridium difficile. (25371529)
2014
6
Glutathione S-transferase Z1 (GSTZ1) gene polymorphism in gastric cancer: a preliminary study in a Turkish population. (24719983)
2014
7
Clinical relevance of tag single nucleotide polymorphisms within the CAT gene in patients with PTSD in the Chongqing Han population. (24817970)
2014
8
Decorin and biglycan immunolocalization in non-villous structures of healthy and pathological human placentas. (24117774)
2014
9
Cervical intradural paraganglioma presenting as progressive cervicodynia: case report and literature review. (22721774)
2013
10
The Prevalence of Macular Cysts in Patients with Clinical Cone-Rod Dystrophy Determined by Spectral-Domain Optical Coherence Tomography. (23758497)
2013
11
The epidermal growth factor-like domain of CD93 is a potent angiogenic factor. (23272129)
2012
12
A rapid assessment of avoidable blindness in Southern Zambia. (22737211)
2012
13
Angiogenic microRNA-210 is present in cells surrounding osteonecrosis. (22287106)
2012
14
Interleukin-10 promoter polymorphisms associated with susceptibility to lumbar disc degeneration in a Chinese cohort. (21863566)
2011
15
The constitutive function of native TRPC3 channels modulates vascular cell adhesion molecule-1 expression in coronary endothelial cells through nuclear factor kappaB signaling. (20360250)
2010
16
Haptoglobin: basic and clinical aspects. (19659435)
2010
17
Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. (19380486)
2009
18
Pivmecillinam versus sulfamethizole for short-term treatment of uncomplicated acute cystitis in general practice: a randomized controlled trial. (18991182)
2009
19
Activation of phospholipase C gamma 1 protects renal arteriolar VSMCs from H2O2-induced cell death. (18004076)
2008
20
Identification of a 26-kDa protein fraction as an important antigen for application in the immunodiagnosis of strongyloidiasis. (17569087)
2007
21
A new in vitro wound model based on the co-culture of human dermal microvascular endothelial cells and human dermal fibroblasts. (17222082)
2007
22
Folliculotropic mycosis fungoides with CD30+ large-cell transformation in a young woman: beneficial effect of bexarotene. (17300259)
2007
23
Biphasic effect of pioglitazone on isolated human endothelial progenitor cells: involvement of peroxisome proliferator-activated receptor-gamma and transforming growth factor-beta1. (17549301)
2007
24
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. (16204462)
2006
25
Oncogene-specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis. (17006931)
2006
26
Opsoclonus persisting during sleep in West Nile encephalitis. (16966514)
2006
27
Necrobiosis lipoidica diabeticorum. (16206686)
2005
28
The hereditary stomatocytoses: genetic disorders of the red cell membrane permeability to monovalent cations. (15071792)
2004
29
Biotinidase Deficiency: New Directions and Practical Concerns. (12791199)
2003
30
Carcinomatous transformation of eccrine syringofibroadenoma. (12641783)
2003
31
Insulin resistance, inflammation, and the prediabetic state. (12957323)
2003
32
Postconization surveillance of cervical adenocarcinoma in situ. A prospective trial. (14619639)
2003
33
Rapid Ca2+-dependent decrease of protein ubiquitination at synapses. (14657369)
2003
34
The adjunctive value of routine biochemistry in nutritional assessment of hospitalized patients. (11883995)
2001
35
Alterations of haemostatic and fibrinolytic markers in adult patients with growth hormone deficiency and with acromegaly. (11083070)
2000
36
Differential effects of ethanol on signal transduction. (10656198)
2000
37
Contribution of cholescintigraphy to the early diagnosis of acute acalculous cholecystitis in intensive-care-unit patients. (10541831)
1999
38
Deficiency of connexin43 gap junctions is an independent marker for breast tumors. (10463615)
1999
39
Bilateral internal jugular venous thrombosis complicating severe ovarian hyperstimulation syndrome after prophylactic albumin administration. (9207607)
1997
40
Ketoacids attenuate glucose uptake in human trophoblasts isolated from first-trimester chorionic villi. (8694076)
1996
41
Sensitization induced by kindling and kindling-related phenomena as a model for multiple chemical sensitivity. (8711751)
1996
42
Determination of the catalytic site of creatine kinase by site- directed mutagenesis. (8186255)
1994
43
Acute effects of a single administration of dexamethasone on basal and growth hormone-releasing hormone stimulated GH secretion in acromegaly. (8137516)
1994
44
GAP-43 phosphorylation is dynamically regulated in individual growth cones. (1460463)
1992
45
Placental chorioangioma: a case report and review. (1598615)
1992
46
Spastic hypertonia: mechanisms and measurement. (2644919)
1989
47
The Hermansky-Pudlak syndrome. Report of three cases and review of pathophysiology and management considerations. (3921802)
1985
48
Pathogenesis and lesions of swine dysentery induced by artificial methods in early weaned pigs. (7008329)
1980
49
Relationship of nodular goiter to thyroid carcinoma; brief review with a note on the diagnostic role of needle biopsy. (15394618)
1949
50

Variations for Lymphangioma

About this section

Expression for genes affiliated with Lymphangioma

About this section
Search GEO for disease gene expression data for Lymphangioma.

Pathways for genes affiliated with Lymphangioma

About this section

Pathways related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.9FLT4, VEGFC
29.8EGFR, FLT4
39.4EGFR, PIK3CA
49.4EGFR, PIK3CA
59.4EGFR, PIK3CA
69.4EGFR, PIK3CA
7
Show member pathways
9.4EGFR, FLT4, VEGFC
89.4EGFR, PIK3CA
99.4EGFR, PIK3CA
109.3IFNG, PIK3CA
119.2FLT4, PIK3CA, VEGFC
12
Show member pathways
9.2FLT4, PIK3CA, VEGFC
139.2EGFR, IFNA2, IFNG
149.1HBA1, IFNG
159.1EGFR, IFNA2, PIK3CA
16
Show member pathways
9.0IFNA2, IFNG, PIK3CA
178.9EGFR, IFNG, PIK3CA
18
Show member pathways
8.8EGFR, IFNG, PIK3CA
19
Show member pathways
8.8EGFR, FLT4, PIK3CA, VEGFC
20
Show member pathways
8.8EGFR, FLT4, PIK3CA, VEGFC
218.4EGFR, FLT4, IFNA2, PIK3CA, VEGFC
22
Show member pathways
8.1EGFR, FLT4, IFNA2, IFNG, SERPINF1, VEGFC

GO Terms for genes affiliated with Lymphangioma

About this section

Biological processes related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:003314110.2IFNA2, IFNG
2lymph vessel developmentGO:000194510.2FLT4, PROX1
3positive regulation of phosphorylationGO:004232710.0EGFR, IFNA2
4phosphatidylinositol phosphorylationGO:00468549.8EGFR, PIK3CA
5ERBB2 signaling pathwayGO:00381289.8EGFR, PIK3CA
6cellular response to glucose stimulusGO:00713339.6PIK3CA, SERPINF1
7positive regulation of cell proliferationGO:00082849.3FLT4, IFNG, PROX1
8negative regulation of cell proliferationGO:00082859.3IFNG, PROX1, VEGFC
9vascular endothelial growth factor receptor signaling pathwayGO:00480108.5EGFR, FLT4, PIK3CA, VEGFC

Sources for Lymphangioma

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet