MCID: LYM022
MIFTS: 46

Lymphangioma malady

Rare diseases, Cancer diseases, Immune diseases categories

Aliases & Classifications for Lymphangioma

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Aliases & Descriptions for Lymphangioma:

Name: Lymphangioma 10 45 47 12 65 36
Congenital Lymphangioma 10
 
Benign Lymphangioma 10
Lymphangiomas 45


Classifications:



External Ids:

Disease Ontology10 DOID:1475
NCIt42 C8965
MeSH36 D008202
ICD9CM29 228.1
ICD1027 D18.1

Summaries for Lymphangioma

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NIH Rare Diseases:45 Lymphangioma is a benign (non-cancerous) mass made of fluid-filled spaces, which is thought to occur due to abnormal development of the lymphatic system. they are always present at birth, although they may change and become more apparent over time. lymphangiomas are most commonly found in the head and neck region, but can affect almost any part of the body (except the brain). some may appear as a tiny blue or red spot while others are massive and affect an entire limb (arm or leg). the signs and symptoms vary depending on the size and location of the mass; however, lymphangiomas can disfigure affected areas and potentially disrupt the function of nearby organs or tissues regardless of size. the exact underlying cause is unknown. treatment options vary based on the signs and symptoms present in each person but may include surgery. last updated: 12/20/2014

MalaCards based summary: Lymphangioma, also known as congenital lymphangioma, is related to hemangioma thrombocytopenia syndrome and cellulitis. An important gene associated with Lymphangioma is FLT4 (Fms-Related Tyrosine Kinase 4), and among its related pathways are VEGFR3 signaling in lymphatic endothelium and . Affiliated tissues include pancreas, lymph node and tongue, and related mouse phenotypes are liver/biliary system and vision/eye.

Wikipedia:68 Lymphangiomas are malformations of the lymphatic system characterized by lesions that are thin-walled... more...

Related Diseases for Lymphangioma

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Diseases related to Lymphangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 212)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioma thrombocytopenia syndrome30.2FLT4, KDR
2cellulitis29.8EGFR, PDPN, VEGFA, VEGFC
3kaposi sarcoma29.5FLT4, IFNA2, KDR, PDPN, VEGFA, VEGFC
4cystic lymphangioma11.2
5cavernous lymphangioma10.8
6orbital lymphangioma10.7
7mediastinitis10.6
8abdominal cystic lymphangioma10.6
9pancreatitis10.6
10cervicitis10.5
11lymphangiomatosis10.4
12microcystic lymphatic malformation10.4
13hepatitis10.4
14endotheliitis10.4
15hemangioma10.4
16colonic lymphangioma10.4
17macrocystic lymphatic malformation10.4
1815q11.2 microdeletion10.3FLT4, VEGFC
19capillary lymphangioma10.3
20appendicitis10.3
21sarcoma10.3
22primary laryngeal lymphangioma10.3
23diffuse lymphatic malformation10.3
24central nervous system hemangioma10.3FLT4, PDPN
25prostate angiosarcoma10.2FLT4, KDR
26hemangioma, capillary infantile10.2FLT4, KDR
27klippel-trenaunay-weber syndrome10.2
28intussusception10.2
29adenomatoid tumor10.2
30esophagitis10.2
31cobb syndrome10.2
32lymphangiectasis10.2
33macroglossia10.2
34red cell phospholipid defect with hemolysis10.2EGFR, IFNA2
35schizophreniform disorder10.2FLT4, PROX1
36scrotum basal cell carcinoma10.2EGFR, PDPN
37spinal cord disease10.2EGFR, KDR
38middle cranial fossa meningioma10.2EGFR, KDR
39hemiplegia alterans10.2FLT4, VEGFA
40cervical benign neoplasm10.1EGFR, KDR
41proteus syndrome, somatic10.1
42urethritis10.1
43tonsillitis10.1
44duodenitis10.1
45laryngitis10.1
46chylous ascites10.1
47hemangioendothelioma10.1
48weber syndrome10.1
49circumscribed lymphatic malformation10.1
50teratoma10.1

Graphical network of the top 20 diseases related to Lymphangioma:



Diseases related to lymphangioma

Symptoms for Lymphangioma

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Drugs & Therapeutics for Lymphangioma

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Drugs for Lymphangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1PicibanilPhase 2, Phase 37
2
Sildenafilapproved, investigationalPhase 1, Phase 2296139755-83-25212
Synonyms:
1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-D)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine
1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine
1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate
139755-83-2
171599-83-0 (citrate)
1udt
1xos
2h42
5-(2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one (Sildenafil or Viagra)
5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one(Sildenafil)
5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
5-{2-(ethyloxy)-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
AC-938
AC1L1JUI
Ambap139755-83-2
Aphrodil
Aphrodil (TN)
BAS 04213629
BIDD:GT0352
BRD-K79759585-001-02-1
BSPBio_003424
C07259
C22H30N6O4S
CHEBI:9139
CHEMBL192
CID5212
Caverta
D08514
DB00203
DivK1c_006894
HMS1684K08
HMS1922B19
HMS2089M12
HMS2093O17
HSDB 7305
 
I06-0023
Jsp002373
KBio1_001838
KBio2_002035
KBio2_004603
KBio2_007171
KBio3_002927
KBioGR_001052
KBioSS_002035
LS-111655
MLS001240224
MLS001304737
MolPort-001-995-394
MolPort-002-885-861
NCGC00095099-01
NCGC00095099-02
NCGC00159496-02
Revatio
SMR000752512
SPBio_001775
SPECTRUM1504099
Sildenafil
Sildenafil (INN)
Sildenafil Citrate
Sildenafil Viagra
Sildenafil [INN:BAN]
Sildenafil citrate
SpecPlus_000798
Spectrum2_001648
Spectrum3_001892
Spectrum4_000586
Spectrum5_001508
Spectrum_001555
UK-92,480-10
UK-92480
UNII-3M7OB98Y7H
VIA
Viagra
sildenafil
3Phosphodiesterase 5 InhibitorsPhase 1, Phase 2518
4
PancrelipaseapprovedPhase 083953608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
Creon
PA
Pancreatic alpha-amylase precursor
Pancreaze
 
Pancrelipase
Pertzye
Polocaine-mpf
Ultresa
Viokace
Zenpep
5pancreatinPhase 0839

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic MalformationsCompletedNCT00010452Phase 2, Phase 3
2A Study to Evaluate Sildenafil for the Treatment of Lymphatic MalformationsCompletedNCT01290484Phase 1, Phase 2
3AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome)RecruitingNCT02250456
4Needle-based Confocal Laser Endomicroscopy on Pancreatic Cystic LesionsRecruitingNCT02494388Phase 0
5Lymphatic Anomalies RegistryRecruitingNCT02399527
6Characterization of the Pathogenesis of Primary and Secondary Lymphatic DisordersRecruitingNCT02156115

Search NIH Clinical Center for Lymphangioma


Cochrane evidence based reviews: Lymphangioma

Genetic Tests for Lymphangioma

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Anatomical Context for Lymphangioma

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MalaCards organs/tissues related to Lymphangioma:

33
Pancreas, Lymph node, Tongue, Brain, Colon, Spleen, Breast

Animal Models for Lymphangioma or affiliated genes

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MGI Mouse Phenotypes related to Lymphangioma:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5EGFR, FLT4, KDR, PROX1, VEGFA
2MP:00053918.0EGFR, KDR, PROX1, SERPINF1, VEGFA
3MP:00028738.0ACTC1, EGFR, FLT4, KDR, PROX1, VEGFA
4MP:00053818.0EGFR, FLT4, PDPN, PROX1, SERPINF1, VEGFA
5MP:00053888.0EGFR, KDR, PDPN, PROX1, VEGFA
6MP:00053697.8ACTC1, EGFR, FLT4, KDR, PDPN, VEGFA
7MP:00053877.4EGFR, FLT4, KDR, PDPN, PROX1, VEGFA
8MP:00053787.3ACTC1, EGFR, FLT4, KDR, PDPN, PROX1
9MP:00107687.1ACTC1, EGFR, FLT4, KDR, PDPN, PROX1
10MP:00053856.6ACTC1, EGFR, FLT4, KDR, PDPN, PROX1
11MP:00053766.6ACTC1, EGFR, FLT4, KDR, PDPN, PROX1

Publications for Lymphangioma

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Articles related to Lymphangioma:

(show top 50)    (show all 899)
idTitleAuthorsYear
1
Coexisting pancreatic mucinous cyst adenoma and adrenal lymphangioma. (25224209)
2014
2
Cystic lymphangioma of the chest wall: a case report. (25606029)
2014
3
Unusual sites of cystic lymphangioma in children. (25282458)
2014
4
Asymptomatic lymphangioma involving the spleen and mediastinum in adults. (23702506)
2013
5
Thoracic Cavernous Lymphangioma Provoking Massive Chyloptysis: A Case Report. (26425583)
2013
6
Lymphangioma circumscriptum of the tongue in children: successful treatment using intralesional bleomycin. (23732020)
2013
7
Complete Resolution of Retroperitoneal Lymphangioma with a Single Trial of OK-432 in an Infant. (24140312)
2013
8
Pericardial cystic lymphangioma. (23034994)
2013
9
Sildenafil for pediatric orbital lymphangioma. (23828510)
2013
10
Combined Mesothelial Cyst and Lymphangioma of the Small Bowel: A Distinct Hybrid Intra-Abdominal Cyst. (24220997)
2013
11
Splenic artery rupture during pregnancy concealed by a pancreatic lymphangioma: a rare co-occurrence. (23088804)
2013
12
Intestinal obstruction complicating a mesenteric cystic lymphangioma. (22795361)
2012
13
Mediastinal lymphangioma treated using endobronchial ultrasound-guided transbronchial needle aspiration. (23018866)
2012
14
Huge cystic lymphangioma of the pancreas mimicking pancreatic cystic neoplasm. (23197988)
2012
15
Robot-assisted laparoscopic removal of perirenal lymphangioma: a case report. (23210414)
2012
16
Lymphangioma: Is intralesional bleomycin sclerotherapy effective? (22279495)
2011
17
Acquired progressive lymphangioma in a 75-year-old man at the site of surgery 22 years previously. (21468468)
2011
18
Cystic retroperitoneal lymphangioma. (20557520)
2010
19
Lymphangioma circumscriptum. (21048263)
2010
20
Anaesthetic consideration in macroglossia due to lymphangioma of tongue: a case report. (20640084)
2009
21
Solitary hepatic lymphangioma in a 22-day-old infant. (19635291)
2009
22
Vulvar lymphangioma circumscriptum. (19682682)
2009
23
Acquired progressive lymphangioma with atypical clinical presentation. (19171542)
2009
24
Giant lymphangioma of the tongue. (19165040)
2009
25
Lymphangioma circumscriptum of the tongue: successful treatment using intralesional bleomycin. (19545460)
2009
26
Cystic lymphangioma of the breast in a 6-year-old boy. (19853765)
2009
27
Haemorrhage in a scrotal lymphangioma in a child: a rarity. (19661642)
2009
28
Cystic lymphangioma of the gallbladder: report of a case. (18085372)
2008
29
Treatment of lymphangioma in children: our experience of 128 cases. (17270554)
2007
30
Cavernous mesenteric lymphangioma (2006: 4b). (16770656)
2006
31
Prenatal diagnosis of a fetal chest wall cystic lymphangioma using ultrasonography and MRI: a case report with literature review. (16260884)
2005
32
Orbital lymphangioma. (15234158)
2004
33
Abdominal cystic lymphangioma: a rare cause of acute abdomen in a neonate. (11737721)
2001
34
Giant cystic lymphangioma of the stomach. (11841086)
2001
35
Immunomodulatory treatment with low-dose interferon-alpha and oral retinoic acid in lymphangioma-like Kaposi's sarcoma. (10769722)
2000
36
Protein-loss into retroperitoneal lymphangioma: demonstration by lymphoscintigraphy and blood-pool scintigraphy with Tc-99m-human serum albumin. (10830532)
2000
37
Abdominal cystic lymphangioma in a woman at 14 weeks' gestation: case report. (11055491)
2000
38
Management of orbital lymphangioma using intralesional injection of OK-432. (10837387)
2000
39
Sotradecol (sodium tetradecyl sulfate) injection of orbital lymphangioma. (10588254)
1999
40
Mediastinal cystic lymphangioma: report of two cases. (9323827)
1997
41
Radiology/pathology conference: mesenteric cystic lymphangioma. (8692443)
1996
42
Abdominal cystic lymphangioma in children: benign lesions that can have a proliferative course. (8861480)
1996
43
Cystic lymphangioma of the transverse colon: report of a case and review of the literature. (8832861)
1996
44
Laparoscopic resection of a retroperitoneal cystic lymphangioma. (7878511)
1994
45
Case report: MRI and CT comparison of an orbital cavernous lymphangioma. (1753396)
1991
46
Torsion of cavernous lymphangioma: an unusual cause of acute scrotum. (2810511)
1989
47
Hyponatremia resulting from loss of lymphatic fluid in an infant with cystic lymphangioma. (3723245)
1986
48
Sonographic appearance of an abdominal cystic lymphangioma. (6699930)
1984
49
Cystic lymphangioma of the parotid region. (14417246)
1960
50
CYSTIC LYMPHANGIOMA OF THE GREAT OMENTUM. (17863276)
1914

Variations for Lymphangioma

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Expression for genes affiliated with Lymphangioma

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Search GEO for disease gene expression data for Lymphangioma.

Pathways for genes affiliated with Lymphangioma

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Pathways related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9FLT4, VEGFC
2
Angiogenesis (WikiPathways)
Show member pathways
9.6FLT4, VEGFC
3
Angiogenesis (CST)
Show member pathways
9.1FLT4, VEGFC
4
Show member pathways
9.0FLT4, KDR, VEGFA, VEGFC
5
Show member pathways
9.0FLT4, KDR, VEGFA, VEGFC
6
Show member pathways
9.0FLT4, KDR, VEGFA, VEGFC
78.9EGFR, FLT4, KDR
88.8EGFR, KDR, VEGFA
98.8EGFR, KDR, VEGFA
108.6EGFR, FLT4, KDR, VEGFC
11
Show member pathways
8.6EGFR, FLT4, KDR, VEGFC
128.5EGFR, FLT4, KDR, VEGFA
13
VEGF Pathway (Qiagen)
Show member pathways
8.2EGFR, FLT4, KDR, VEGFA
14
Show member pathways
8.2EGFR, FLT4, KDR, VEGFA, VEGFC
15
Show member pathways
8.2EGFR, FLT4, KDR, VEGFA, VEGFC
16
Show member pathways
8.2EGFR, FLT4, KDR, VEGFA, VEGFC
17
Show member pathways
8.2EGFR, FLT4, KDR, VEGFA, VEGFC
18
Show member pathways
7.5EGFR, FLT4, IFNA2, KDR, VEGFA, VEGFC
197.5EGFR, FLT4, IFNA2, KDR, VEGFA, VEGFC
20
Show member pathways
7.0EGFR, FLT4, IFNA2, KDR, SERPINF1, VEGFA

GO Terms for genes affiliated with Lymphangioma

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Cellular components related to Lymphangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.5FLT4, IFNA2, KDR, SERPINF1, VEGFA, VEGFC
2extracellular spaceGO:00056157.2ACTC1, EGFR, IFNA2, SERPINF1, VEGFA, VEGFC

Biological processes related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein kinase C signalingGO:009003710.3FLT4, VEGFA
2positive regulation of neuroblast proliferationGO:000205210.3VEGFA, VEGFC
3positive regulation of blood vessel endothelial cell migrationGO:004353610.3VEGFA, VEGFC
4endothelial cell differentiationGO:004544610.3KDR, PROX1
5positive regulation of cell divisionGO:005178110.3VEGFA, VEGFC
6positive regulation of protein autophosphorylationGO:003195410.3VEGFA, VEGFC
7positive regulation of lymphangiogenesisGO:190149210.3VEGFA, VEGFC
8positive regulation of cellular component movementGO:005127210.3PDPN, VEGFA
9positive regulation of mast cell chemotaxisGO:006075410.3VEGFA, VEGFC
10vasculature developmentGO:000194410.3FLT4, VEGFA
11regulation of hematopoietic progenitor cell differentiationGO:190153210.3KDR, VEGFA
12positive regulation of positive chemotaxisGO:005092710.3KDR, VEGFA
13surfactant homeostasisGO:004312910.3KDR, VEGFA
14positive regulation of mesenchymal cell proliferationGO:000205310.3KDR, VEGFA
15cell migration involved in sprouting angiogenesisGO:000204210.3KDR, VEGFA
16positive regulation of focal adhesion assemblyGO:005189410.2KDR, VEGFA
17regulation of endothelial cell differentiationGO:004560110.2KDR, VEGFA
18skeletal muscle thin filament assemblyGO:003024010.2ACTC1, PROX1
19branching morphogenesis of an epithelial tubeGO:004875410.2KDR, VEGFA
20positive chemotaxisGO:005091810.2VEGFA, VEGFC
21induction of positive chemotaxisGO:005093010.1VEGFA, VEGFC
22lymph vessel developmentGO:000194510.1FLT4, KDR, PROX1
23vascular endothelial growth factor signaling pathwayGO:003808410.0FLT4, KDR, VEGFA
24cellular response to vascular endothelial growth factor stimulusGO:003592410.0FLT4, KDR, VEGFA
25angiogenesisGO:00015259.7KDR, VEGFA, VEGFC
26positive regulation of angiogenesisGO:00457669.6KDR, VEGFA, VEGFC
27regulation of cell shapeGO:00083609.6KDR, PDPN, VEGFA
28lymphangiogenesisGO:00019469.6FLT4, PDPN, PROX1, VEGFA
29positive regulation of endothelial cell migrationGO:00105959.6FLT4, KDR, PROX1, VEGFA
30kidney developmentGO:00018229.4PROX1, SERPINF1, VEGFA
31blood vessel morphogenesisGO:00485149.4FLT4, VEGFA
32positive regulation of endothelial cell proliferationGO:00019389.4FLT4, KDR, PROX1, VEGFA
33transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.3EGFR, FLT4, KDR
34protein autophosphorylationGO:00467779.3EGFR, FLT4, KDR
35positive regulation of phosphorylationGO:00423279.3EGFR, IFNA2
36lung developmentGO:00303249.2KDR, PDPN, PROX1, VEGFA
37positive regulation of cell migrationGO:00303359.2EGFR, KDR, VEGFA
38positive regulation of epithelial cell proliferationGO:00506799.1EGFR, KDR, VEGFA, VEGFC
39peptidyl-tyrosine phosphorylationGO:00181089.0EGFR, FLT4, KDR
40positive regulation of protein phosphorylationGO:00019348.9EGFR, FLT4, KDR, VEGFA
41cell proliferationGO:00082838.5EGFR, PDPN, SERPINF1, VEGFA
42positive regulation of ERK1 and ERK2 cascadeGO:00703748.5EGFR, FLT4, KDR, VEGFA
43negative regulation of apoptotic processGO:00430668.2ACTC1, EGFR, FLT4, KDR, VEGFA
44vascular endothelial growth factor receptor signaling pathwayGO:00480108.2EGFR, FLT4, KDR, VEGFA, VEGFC
45positive regulation of cell proliferationGO:00082848.0EGFR, FLT4, KDR, PROX1, VEGFA, VEGFC

Molecular functions related to Lymphangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:000502110.2FLT4, KDR
2growth factor bindingGO:001983810.1FLT4, KDR
3chemoattractant activityGO:00420569.8VEGFA, VEGFC
4receptor signaling protein tyrosine kinase activityGO:00047169.6EGFR, KDR
5protein tyrosine kinase activityGO:00047138.9EGFR, FLT4, KDR
6transmembrane receptor protein tyrosine kinase activityGO:00047148.6EGFR, FLT4, KDR

Sources for Lymphangioma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet