MCID: LYM022
MIFTS: 49

Lymphangioma malady

Cancer category

Summaries for Lymphangioma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Lymphangiomas are malformations of the lymphatic system, which is the network of vessels responsible for... more...

MalaCards: Lymphangioma, also known as lymphangioma of unspecified site, is related to cystic lymphangioma and kaposi's sarcoma. An important gene associated with Lymphangioma is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are Signaling by VEGF and Presynaptic nicotinic acetylcholine receptors. The compounds galantamine and sialic acid have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and muscle.

Aliases & Classifications for Lymphangioma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

lymphangioma 8 43 10 45 61
lymphangioma of unspecified site 8
lymphangioma, no icd-o subtype 8
congenital lymphangioma 8
lymphangioma, any site 8
benign lymphangioma 8
lymphangioma nos 8
lymphangiomas 43


External Ids:

Disease Ontology8 DOID:1475
MeSH35 D008202
NCIt40 C8965
ICD9CM27 228.1
ICD1025 D18.1

Related Diseases for Lymphangioma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lymphangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1cystic lymphangioma31.7AFP, CHRNG, CHRND, MAST4, HIRA, EIF3M
2kaposi's sarcoma30.3CD34
3adenoma30.2ACTC1, FLT4
4hemangioendothelioma30.1CD34, FLT4
5teratoma30.1PDPN, AFP, ACTC1
6lymphangiosarcoma30.0PROX1
7wilms tumor29.8ACTC1, VEGFC, PDPN
8squamous cell carcinoma29.8PDPN, FLT4, VEGFC, CD34, ACTC1, PTCH1
9cavernous lymphangioma10.8
10orbital lymphangioma10.7
11abdominal cystic lymphangioma10.6
12lymphangiomatosis10.4
13lymphatic malformation10.4
14microcystic lymphatic malformation10.3
15colonic lymphangioma10.3
16macrocystic lymphatic malformation10.3
17capillary lymphangioma10.2
18lymphangiectasis10.2
19klippel-trenaunay syndrome10.2
20intussusception10.2
21appendicitis10.2
22adenomatoid tumor10.2
23macroglossia10.2
24hygroma cervical10.2
25cobb syndrome10.1
26weber syndrome10.1
27diffuse lymphatic malformation10.1
28cellulitis10.0
29celiac disease10.0
30n syndrome10.0
31adrenal adenoma10.0
32thrombocytopenia10.0
33blue rubber bleb nevus syndrome10.0
34chylous ascites10.0
35splenomegaly10.0
36primary laryngeal lymphangioma10.0
37intestinal lymphangiectasia10.0
38hemangioblastoma10.0PDPN
39fetal akinesia deformation sequence10.0RAPSN
40peritonitis10.0PECAM1
41capillary hemangioma10.0CD34
42oligohydramnios10.0AFP
43nicotine dependence10.0CHRNB1
44hydrocele10.0FLT4
45multiple pterygium syndrome lethal type10.0CHRNG, CHRND
46malignant mesothelioma10.0FLT4, PDPN
47slow-channel congenital myasthenic syndrome10.0CHRND, CHRNB1
48congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.0CHRNB1, RAPSN
49epithelioid hemangioendothelioma10.0FLT4, CD34
50spindle cell sarcoma10.0FLT4, ACTC1

Graphical network of the top 20 diseases related to Lymphangioma:



Diseases related to lymphangioma

Clinical Features for Lymphangioma

Drugs & Therapeutics for Lymphangioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Lymphangioma

Drug clinical trials:

Search ClinicalTrials for Lymphangioma

Search NIH Clinical Center for Lymphangioma

Search CenterWatch for Lymphangioma

Genetic Tests for Lymphangioma

Anatomical Context for Lymphangioma

Animal Models for Lymphangioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Lymphangioma

Sources:
51PubMed
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Articles related to Lymphangioma:

(show top 50)    (show all 1044)
idTitleAuthorsYear
1
Rare case of a solitary huge hepatic cystic lymphangioma. (24303489)
2013
2
Pleuroperitoneal Shunt for Refractory Chylothorax Accompanied with a Mediastinal Lymphangioma: A Case Report. (24088913)
2013
3
A rapidly growing neck mass in childhood: Castleman's disease concomitant with cavernous lymphangioma in the posterior cervical region. (23682944)
2013
4
Lymphangioma-Like Kaposi's Sarcoma Presenting as Gangrene. (23781364)
2013
5
Intestinal obstruction complicating a mesenteric cystic lymphangioma. (22795361)
2012
6
Jejunal lymphangioma: rare case of GI bleeding. (22867445)
2012
7
Robotic partial cystectomy for lymphangioma of the urinary bladder in an adult woman. (22396382)
2012
8
Lymphangioma circumscriptum of the vulva: a rare case report. (22901902)
2012
9
Acquired progressive lymphangioma in a 75-year-old man at the site of surgery 22 years previously. (21468468)
2011
10
The "lymphangioma": an incorrect and outdated term. (21822096)
2011
11
Cystic lymphangioma of the pancreas mimicking pancreatic pseudocyst. (22066085)
2011
12
Giant mesenteric cystic lymphangioma originating from the lesser omentum in the abdominal cavity. (22324018)
2011
13
A case of middle-ear cavernous lymphangioma with facial palsy. (21205371)
2011
14
EXIT (Ex Utero Intrapartum Treatment) technique - management of a giant fetal lymphangioma. (19626572)
2010
15
Primary lymphangioma of the thyroid gland. (19500020)
2009
16
A rare case of lumbar vertebral lymphangioma presenting as chylothorax. (19243995)
2009
17
Adult presentation of giant retroperitoneal cystic lymphangioma: case report. (19815102)
2009
18
Lymphangioma circumscriptum. (18627763)
2008
19
Dermoscopic-histopathologic correlation of cutaneous lymphangioma circumscriptum. (19075163)
2008
20
Ultrasound biomicroscopy of eyelid lymphangioma in a child. (18286967)
2008
21
Lymphangioma circumscriptum: pitfalls and problems in definitive management. (18177408)
2008
22
Lymphangioma circumscriptum of the penis: a case report. (17992464)
2007
23
A case of lymphangioma circumscriptum developed on the finger. (17451594)
2007
24
Cavernous transverse mesocolonic lymphangioma in an adult. (17512288)
2007
25
Bilateral orbital lymphangiomas in two patients with generalized lymphangiomatosis. (17353319)
2007
26
Giant lymphangioma circumscriptum mimicking wart in a 13-year-old girl. (16848827)
2006
27
Massive cavernous lymphangioma of the breast and thoracic wall: case report and literature review. (17036636)
2006
28
Mediastinal cystic lymphangioma: is resection always necessary? (16037872)
2005
29
Bone lymphangiomatosis: treatment with percutaneous cementoplasty. (15959357)
2005
30
Cystic lymphangioma confined to mediastinum in an adult. (15651402)
2004
31
Mesenteric cystic lymphangioma causing intestinal occlusion in an adult patient. (14722994)
2003
32
Mechanisms of chylous effusion in lymphangiomatosis. (11000195)
2000
33
CT and MR imaging of generalized cystic lymphangiomatosis in pediatric patients. (10701634)
2000
34
Diffuse lymphangiomatosis of bone: comment. (11103555)
2000
35
Sotradecol (sodium tetradecyl sulfate) injection of orbital lymphangioma. (10588254)
1999
36
Orbital lymphangioma: an analysis of 26 patients. (10209440)
1999
37
Endoscopic resection of esophageal lymphangioma incidentally discovered. (18493465)
1998
38
Preoperative diagnosis of cystic lymphangioma of the colon by endoscopic ultrasound. (9041015)
1997
39
Lymphangiomatosis presenting with bronchial cast formation. (8882088)
1996
40
Retroperitoneal cystic lymphangioma in adults. (8161371)
1993
41
Magnetic resonance imaging of orbital lymphangioma with and without gadolinium contrast enhancement. (1513586)
1992
42
Computed tomography of cystic lymphangioma in a wandering spleen. (2278783)
1990
43
CT and MR imaging in cystic abdominal lymphangiomatosis. (2656785)
1989
44
Cervical bruises--a battered child? Cystic lymphangioma. (3740889)
1986
45
Retrocrural cystic lymphangioma. (3905290)
1985
46
Hygroma (cystic lymphangioma): diagnosis by ultrasound. (7361740)
1980
47
Cystic lymphangioma in a colt. (438053)
1979
48
Cystic lymphangioma of the spleen - a case report. (4435937)
1974
49
Retroperitoneal cystic lymphangioma. (13981295)
1963
50
Angiomatosis (hamartomatous hem-lymphangiomatosis). Report of a case with diffuse involvement. (13757296)
1961

Genetic Variations for Lymphangioma

Expression for genes affiliated with Lymphangioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphangioma

Search GEO for disease gene expression data for Lymphangioma.

Pathways for genes affiliated with Lymphangioma

Sources:
54Reactome, 12EMD Millipore, 4Cell Signaling Technology, 52QIAGEN
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Compounds for genes affiliated with Lymphangioma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Lymphangioma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1galantamine45 50 1112.3CHRNG, CHRND, CHRNB1
2sialic acid4510.3PECAM1
3b 7234510.2AFP, ACTC1, PDPN
4p0054510.1AFP, PECAM1, LYVE1
5matrigel4510.0FLT4, VEGFC, ACTC1, PECAM1
6hematoxylin4510.0PDPN, ACTC1, CD34, PECAM1
7glycosaminoglycan459.8LYVE1, PECAM1, ACTC1
8reticulin459.8CD34, ACTC1
9thymidine45 2410.6AFP, CD34, PECAM1, LYVE1, VEGFC
10progesterone45 60 29 11 2413.5ACTC1, LYVE1, AFP, VEGFC, CD34
11retinoic acid45 2410.5AFP, FLT4, PECAM1, CD34, VEGFC, ACTC1
12estrogen459.4LYVE1, PECAM1, ACTC1, CD34, VEGFC, AFP
13tyrosine459.2VEGFC, CD34, RAPSN, PDPN, PECAM1, PTCH1
14paraffin459.1ACTC1, PDPN, LYVE1, PECAM1, PTCH1, FLT4
15vegf459.1CD34, PDPN, FLT4, PROX1, AFP, VEGFC

GO Terms for genes affiliated with Lymphangioma

Sources:
16Gene Ontology
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Cellular components related to Lymphangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.1CHRNB1, CHRND, CHRNG
2postsynaptic membraneGO:0452119.8CHRNG, RAPSN, CHRNB1, CHRND
3cell junctionGO:0300549.7CHRNB1, CHRNG, CHRND, PECAM1, RAPSN
4integral to plasma membraneGO:0058879.4CHRNG, LYVE1, CD34, PDPN, CHRNB1, FLT4
5plasma membraneGO:0058868.4LYVE1, FLT4, PECAM1, PTCH1, RAPSN, CD34

Biological processes related to Lymphangioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:00727110.2RAPSN, CHRNB1
2glomerular endothelium developmentGO:07201110.1PECAM1, CD34
3lymphangiogenesisGO:00194610.1PROX1, FLT4, PDPN
4skeletal muscle thin filament assemblyGO:03024010.1ACTC1, PROX1
5regulation of membrane potentialGO:04239110.0CHRNG, CHRND, CHRNB1
6transportGO:0068109.8AFP, CHRNG, CHRND, CLIC2, LYVE1
7muscle contractionGO:0069369.8CHRNB1, CHRND, CHRNG
8signal transductionGO:0071659.3PDPN, CHRNG, CHRND, CHRNB1, VEGFC, CD34

Molecular functions related to Lymphangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine receptor activityGO:01546410.2CHRNB1, CHRNG
2channel activityGO:01526710.1CHRNB1, CHRNG
3acetylcholine-activated cation-selective channel activityGO:00488910.1CHRNB1, CHRND, CHRNG
4acetylcholine bindingGO:0421669.9CHRNB1, CHRND

Products for genes affiliated with Lymphangioma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphangioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet