Lymphangioma malady

Wikipedia: Lymphangiomas are malformations of the lymphatic system, which is the network of vessels responsible for...⁴⁴ more...

MalaCards: Lymphangioma, also known as lymphangioma, no icd-o subtype (morphologic abnormality), is related to orbital lymphangioma and cystic lymphangioma. An important gene associated with Lymphangioma is PDPN (podoplanin), and among its related pathways are Highly sodium permeable acetylcholine nicotinic receptors and Development_VEGF-family signaling. The compounds alpha-conotoxin ei and galantamine have been mentioned in the context of this disorder. Affiliated tissues include skin and endothelial, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Descriptions:

lymphangioma 6 30 8 32 43 lymphangioma, no icd-o subtype (morphologic abnormality) 6 benign lymphangioma (morphologic abnormality) 6 lymphangioma of unspecified site (disorder) 6 lymphangioma nos (morphologic abnormality) 6

congenital lymphangioma (disorder) 6 lymphangioma (disorder) 6 congenital lymphangioma 6 lymphangioma, any site 6 lymphangiomas 30

Diseases related to lymphangioma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 215)

id	Related Disease	Score	Top Affiliating Genes
1	orbital lymphangioma	31.5	FLT4, PDPN
2	cystic lymphangioma	27.6	VEZF1, RAPSN, CLIC2, CHRND, MAST4, IFNG
3	kaposi's sarcoma	26.1	VEGFC, KDR, CD34, FLT4, IFNA2, PDPN
4	hemangioma	25.1	KDR, CD34, FLT4, IFNA2, PDPN, ACTC1
5	sarcoma	22.0	VEGFC, KDR, CD34, FLT4, IFNA2, IFNG
6	vascular cancer	13.7	PDPN, PROX1
7	multiple pterygium syndrome lethal type	13.7	CHRND, CHRNG
8	slow-channel congenital myasthenic syndrome	13.7	CHRND, CHRNB1
9	atypical neurofibroma	13.6	CD34, PDPN
10	lymphedema, congenital	13.6	VEGFC, FLT4, PDPN
11	central nervous system germ cell tumor	13.6	PDPN, AFP
12	congenital myasthenic syndrome associated with acetylcholine receptor deficiency	13.5	RAPSN, CHRNB1
13	trichoepithelioma	13.5	CD34, PTCH1, PDPN
14	hereditary lymphedema	13.5	VEGFC, FLT4
15	fetal akinesia deformation sequence	13.5	RAPSN, CHRND, CHRNG
16	oligohydramnios	13.5	CHRND, AFP, CHRNG
17	congenital myasthenic syndrome	13.5	RAPSN, CHRND, CHRNB1
18	ossifying fibroma	13.5	CD34, PTCH1, ACTC1
19	ocular cancer	13.4	VEGFC, TGFB1
20	nephrosis	13.3	PDPN, ACTC1, AFP
21	idiopathic pulmonary fibrosis	13.3	IFNG, ACTC1, TGFB1
22	benign mesothelioma	13.3	CD34, PDPN, ACTC1, PECAM1
23	angiofibroma	13.3	CD34, FLT4, ACTC1
24	inflammatory breast cancer	13.3	VEGFC, PROX1, PECAM1, LYVE1
25	myasthenic syndrome	13.3	RAPSN, CHRND, CHRNB1
26	membranous glomerulonephritis	13.3	IFNG, TGFB1, PECAM1
27	fasciitis	13.3	CD34, IFNG, ACTC1
28	angiomyolipoma	13.2	IFNG, PDPN, ACTC1, TGFB1
29	hemangioma, capillary infantile, somatic	13.2	KDR, FLT4
30	nephroblastoma	13.2	VEGFC, ACTC1, PECAM1, AFP
31	tufted angioma	13.2	FLT4, IFNA2, PROX1
32	arthrogryposis	13.2	RAPSN, CHRND, CHRNG
33	heinz body anemia	13.2	HBA1, HBA2
34	bannayan-riley-ruvalcaba syndrome	13.2	CD34, PTCH1, ACTC1, AFP
35	hemangioma, capillary infantile	13.2	KDR, FLT4
36	histiocytosis	13.2	IFNG, PDPN, ACTC1, PROX1, PECAM1
37	ptosis	13.2	SERPINF1, CHRND, CHRNB1, CHRNG
38	oral lichen planus	13.1	IFNG, PDPN, TGFB1, PECAM1
39	ductal carcinoma in situ	13.1	IFNG, PDPN, ACTC1, TGFB1
40	seminoma	13.1	VEGFC, FLT4, PDPN, TGFB1, AFP
41	hydrops fetalis	13.1	FLT4, HBA1, HBA2
42	peyronie's disease	13.1	IFNA2, TGFB1
43	neurofibroma	13.1	CD34, IFNG, PDPN, ACTC1, TGFB1
44	angiosarcoma of the scalp	13.1	VEGFC, KDR, PECAM1
45	kaposiform hemangioendothelioma	13.0	CD34, FLT4, IFNA2, PROX1
46	proliferative glomerulonephritis	13.0	IFNG, TGFB1, OXA1L
47	hemoglobinopathy	13.0	HBA1, HBA2, PECAM1
48	myasthenia gravis	13.0	RAPSN, CHRND, IFNG, TGFB1, CHRNG
49	gastroenteritis	12.9	VEGFC, FLT4, IFNA2, LYVE1
50	epithelioid sarcoma	12.9	CD34, HBA1, HBA2, PECAM1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to lymphangioma:

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MGI Mouse Phenotypes related to lymphangioma:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.7	CHRNG, DSCAM, RAPSN
2	digestive/alimentary phenotype	MP:0005381	8.9	PROX1, TGFB1, PDPN, PTCH1, IFNG, FLT4
3	integument phenotype	MP:0010771	8.8	CHRNG, HBA2, PDPN, PTCH1, IFNG, FLT4
4	immune system phenotype	MP:0005387	8.0	LYVE1, PECAM1, PROX1, PDPN, PTCH1, F8
5	muscle phenotype	MP:0005369	8.0	CHRNG, PECAM1, TGFB1, HBA2, ACTC1, PDPN
6	cardiovascular system phenotype	MP:0005385	7.4	SERPINF1, LYVE1, PECAM1, PROX1, TGFB1, HIRA
7	homeostasis/metabolism phenotype	MP:0005376	6.6	HIRA, TGFB1, PROX1, PECAM1, AFP, CHRNG
8	mortality/aging	MP:0010768	6.5	HBA2, HIRA, DSCAM, PROX1, AFP, CHRNG

Articles related to lymphangioma:

(show all 14)

id	Title	Authors	Year	Affiliating Genes
1	VEGF-C and VEGFR-3 in a series of lymphangiomas: Is superficial lymphangioma a true lymphangioma? (19151999)	Itakura E.... Tsuneyoshi M.	2009	FLT4, VEGFC
2	Similarities and differences of human and experimental mouse lymphangiomas. (17879316)	Kasten P.... Wilting J.	2007	PROX1
3	Surgery for cystic lymphangioma in Gorlin-Goltz syndrome. (17221269)	Kayser C.... Eggstein S.	2007	PTCH1
4	Elevated expression of VEGFR-3 in lymphatic endothelial cells from lymphangiomas. (17584927)	Norgall S.... Weich H.A.	2007	FLT4, KDR, PROX1
5	Altered pigment epithelium-derived factor and vascular endothelial growth factor levels in lymphangioma pathogenesis and clinical recurrence. (16301371)	Sidle D.M.... Crawford S.E.	2005	SERPINF1
6	A role of cytokines in OK-432 injection therapy for cystic lymphangioma: an approach to the mechanism. (14666473)	Fujino A.... Kitajima M.	2003	TGFB1, IFNG
7	Co-expression of VEGF-C and its receptors, VEGFR-2 and VEGFR-3, in endothelial cells of lymphangioma. Implication in autocrine or paracrine regulation of lymphangioma. (11742043)	Huang H.Y.... Hsu S.M.	2001	FLT4, KDR, VEGFC
8	Orbital lymphangioma with positive immunohistochemistry of lymphatic endothelial markers (vascular endothelial growth factor receptor 3 and podoplanin). (11585321)	Cursiefen C.... Holbach L.M.	2001	FLT4, PDPN
9	Treatment of lymphangioma with alpha-2a-interferon (14647605)	Souza R.J.... Tone L.G.	2001	IFNA2
10	Immunomodulatory treatment with low-dose interferon-alpha and oral retinoic acid in lymphangioma-like Kaposi's sarcoma. (10769722)	Somos S.... Farkas B.	2000	IFNA2
11	Protein-loss into retroperitoneal lymphangioma: demonstration by lymphoscintigraphy and blood-pool scintigraphy with Tc-99m-human serum albumin. (10830532)	Okizaki A.... Aburano T.	2000	OXA1L
12	Lymphangioma of large intestine: report of ten cases with endoscopic and pathologic correlation. (10922105)	Kim K.M.... Kim B.K.	2000	ACTC1
13	Intrapericardial lymphangioma with podoplanin immunohistochemical characterization of lymphatic endothelial cells. (10931742)	Sinzelle E.... Bruneval P.	2000	PDPN
14	Immunoelectron microscopic characterization of human dermal lymphatic microvascular endothelial cells. Differential expression of CD31, CD34, and type IV collagen with lymphatic endothelial cells vs blood capillary endothelial cells in normal human skin, lymphangioma, and hemangioma in situ. (9446823)	Sauter B.... Rappersberger K.	1998	PECAM1

Genes related to lymphangioma according to GeneCards:

(show all 30)

id	Symbol	Description	Score	GeneCards Section Context
1	PDPN	podoplanin	11.0	Publications
2	FLT4	fms-related tyrosine kinase 4	11.0	Publications
3	VEZF1	vascular endothelial zinc finger 1	11.0
4	CHRNB1	cholinergic receptor, nicotinic, beta 1 (muscle)	11.0
5	CHRND	cholinergic receptor, nicotinic, delta (muscle)	11.0
6	CHRNG	cholinergic receptor, nicotinic, gamma (muscle)	11.0
7	LYVE1	lymphatic vessel endothelial hyaluronan receptor 1	11.0	Publications
8	PROX1	prospero homeobox 1	11.0	Publications
9	PECAM1	platelet/endothelial cell adhesion molecule 1	11.0	Publications
10	PTCH1	patched 1	11.0	Publications
11	VEGFC	vascular endothelial growth factor C	11.0	Publications
12	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
13	CD34	CD34 molecule	11.0
14	AFP	alpha-fetoprotein	11.0
15	DSCAM	Down syndrome cell adhesion molecule	11.0
16	TGFB1	transforming growth factor, beta 1	11.0	Publications
17	IFNG	interferon, gamma	11.0	Publications
18	OR5K1	olfactory receptor, family 5, subfamily K, member 1	11.0	Disorders
19	RAPSN	receptor-associated protein of the synapse	11.0
20	EIF3M	eukaryotic translation initiation factor 3, subunit M	11.0
21	CLIC2	chloride intracellular channel 2	11.0	Disorders
22	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	11.0	Publications
23	HBA1	hemoglobin, alpha 1	11.0
24	HBA2	hemoglobin, alpha 2	11.0
25	OXA1L	oxidase (cytochrome c) assembly 1-like	11.0	Publications
26	HIRA	HIR histone cell cycle regulation defective homolog A (S. cerevisiae)	11.0
27	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	11.0	Publications
28	IFNA2	interferon, alpha 2	11.0	Publications
29	MAST4	microtubule associated serine/threonine kinase family member 4	11.0	Disorders
30	F8	coagulation factor VIII, procoagulant component	11.0

Pathways related to lymphangioma according to GeneDecks:

(show all 15)

id	Pathway	Score	Top Affiliating Genes
1	Highly sodium permeable acetylcholine nicotinic receptors38	10.3	CHRND, CHRNG
2	Development_VEGF-family signaling41	9.7	FLT4, KDR, VEGFC
3	Development VEGF-family signaling10	9.7	FLT4, KDR, VEGFC
4	African trypanosomiasis20	9.7	HBA2, HBA1, IFNG
5	VEGF Family Ligands and Receptor Interactions36	9.6	VEGFC, KDR, FLT4
6	Angiogenesis3	9.5	PECAM1, TGFB1, FLT4, KDR, VEGFC
7	Malaria20	9.4	IFNG, HBA1, HBA2, TGFB1, PECAM1
8	p53 Mediated Apoptosis36	9.4	VEGFC, KDR, FLT4, TGFB1
9	DHA Signaling36	9.3	TGFB1, FLT4, KDR, VEGFC, SERPINF1
10	Apoptotic Pathways in Synovial Fibroblasts36	9.3	TGFB1, FLT4, KDR, VEGFC
11	Intracellular Calcium Signaling36	9.3	CHRNG, TGFB1, FLT4, CHRND, KDR, VEGFC
12	eNOS Signaling36	9.2	CHRNG, CHRNB1, TGFB1, FLT4, CHRND, KDR
13	PAK Pathway36	8.9	TGFB1, DSCAM, FLT4, KDR, VEGFC
14	Cytokine-cytokine receptor interaction20	8.8	TGFB1, IFNG, IFNA2, FLT4, KDR, VEGFC
15	JAK-STAT Pathway36	8.8	TGFB1, IFNG, IFNA2, FLT4, KDR, VEGFC

Compounds related to lymphangioma according to GeneDecks:

(show all 44)

id	Compound	Score	Top Affiliating Genes
1	alpha-conotoxin ei42	10.4	CHRNG, CHRNB1, CHRND
2	galantamine32 34 9 9	13.4	CHRNG, CHRNB1, CHRND
3	b 72332	10.3	AFP, ACTC1, PDPN
4	pirfenidone32	10.3	IFNG, TGFB1
5	hematoxylin32	10.2	PECAM1, ACTC1, PDPN, CD34
6	azd 217132	10.2	KDR, FLT4
7	sunitinib malate42	10.2	KDR, FLT4
8	axitinib32 42	11.1	FLT4, KDR
9	su 541642	10.1	KDR, FLT4
10	p00532	10.1	PECAM1, LYVE1, AFP
11	larifan32	10.0	IFNA2, IFNG
12	ridostin32	10.0	IFNA2, IFNG
13	rhein32	9.9	OXA1L, TGFB1
14	cyclophosphamide32 34 9 9	12.9	F8
15	glycosaminoglycan32	9.8	LYVE1, PECAM1, TGFB1, ACTC1, SERPINF1
16	methylcellulose32	9.8	CD34, IFNG, TGFB1
17	acyclovir32	9.8	IFNA2, IFNG, AFP
18	con a32	9.7	IFNA2, IFNG, AFP
19	sialic acid32	9.6	AFP, PECAM1, PDPN, F8
20	polyvinyl alcohol32	9.6	OXA1L, IFNA2
21	heparin32 9 18 9	12.4	SERPINF1, VEGFC, F8, AFP
22	ribonucleic acid32	9.4	VEGFC, IFNA2, ACTC1, TGFB1, PECAM1
23	oxygen32 18	10.3	PECAM1, HBA2, HBA1, ACTC1, FLT4, SERPINF1
24	thalidomide32 42 9 9	12.3	KDR, IFNA2, IFNG, AFP
25	glucose32	9.3	LYVE1, ACTC1, IFNA2, VEGFC, SERPINF1
26	carboplatin32 34 9 9	12.3	AFP, IFNG, IFNA2, KDR
27	gold32	9.2	AFP, PDPN, F8, IFNA2
28	streptozotocin32	9.2	SERPINF1, KDR, IFNA2, TGFB1
29	matrigel32	9.1	PECAM1, TGFB1, ACTC1, FLT4, KDR, VEGFC
30	agar32	9.1	AFP, PECAM1, IFNA2, CD34, KDR
31	polysaccharide32	9.1	AFP, TGFB1, PDPN, F8, KDR
32	tgf beta132	9.0	KDR, F8, TGFB1, AFP
33	cyclosporin a32 42	9.9	PECAM1, TGFB1, ACTC1, F8, IFNG, KDR
34	polyethylene glycol32	8.9	AFP, OXA1L, TGFB1, F8, IFNA2
35	progesterone32 42 9 18 9	12.7	AFP, LYVE1, ACTC1, F8, IFNA2, CD34
36	thyroxine32 18	9.7	AFP, OXA1L, TGFB1, IFNA2
37	paraffin32	8.6	AFP, LYVE1, PECAM1, TGFB1, ACTC1, PDPN
38	iron32 18	9.5	AFP, HBA2, HBA1, ACTC1, F8, IFNA2
39	dexamethasone32 42 34 9 9	12.3	AFP, TGFB1, ACTC1, F8, IFNG, FLT4
40	thymidine32 18	9.0	TGFB1, PECAM1, LYVE1, AFP, HBA2, IFNG
41	retinoic acid32 42 18	9.9	AFP, PECAM1, TGFB1, ACTC1, IFNG, IFNA2
42	estrogen32	7.7	AFP, LYVE1, PECAM1, TGFB1, ACTC1, F8
43	vegf32	6.9	SERPINF1, AFP, LYVE1, PECAM1, PROX1, TGFB1
44	tyrosine32	6.9	PTCH1, PDPN, ACTC1, HBA2, PECAM1, AFP

Cellular components related to lymphangioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell junction	GO:030054	9.6	RAPSN, CHRND, PECAM1, CHRNB1, CHRNG
2	platelet alpha granule lumen	GO:031093	9.4	TGFB1, F8, VEGFC
3	integral to plasma membrane	GO:005887	8.8	CHRNG, CHRNB1, LYVE1, DSCAM, PDPN, FLT4
4	extracellular space	GO:005615	8.0	SERPINF1, AFP, PECAM1, TGFB1, F8, IFNG
5	extracellular region	GO:005576	7.2	TGFB1, DSCAM, F8, IFNG, IFNA2, FLT4

Biological processes related to lymphangioma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	lymphangiogenesis	GO:001946	10.3	FLT4, PDPN, PROX1
2	glomerular endothelium development	GO:072011	10.3	CD34, PECAM1
3	skeletal muscle thin filament assembly	GO:030240	10.1	PROX1, ACTC1
4	positive regulation of odontogenesis	GO:042482	10.1	TGFB1, CD34
5	endothelium development	GO:003158	9.9	KDR, CD34
6	vascular endothelial growth factor receptor signaling pathway	GO:048010	9.9	VEGFC, KDR, FLT4
7	positive regulation of endothelial cell migration	GO:010595	9.9	PROX1, FLT4, KDR
8	lymph vessel development	GO:001945	9.8	KDR, FLT4
9	platelet degranulation	GO:002576	9.6	PECAM1, TGFB1, F8, VEGFC
10	transport	GO:006810	9.4	CHRNG, AFP, LYVE1, CHRND, CLIC2
11	positive regulation of endothelial cell proliferation	GO:001938	9.4	KDR, FLT4, PROX1
12	signal transduction	GO:007165	9.1	CHRNG, CHRNB1, PECAM1, PDPN, CD34, CHRND

Molecular functions related to lymphangioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	acetylcholine-activated cation-selective channel activity	GO:004889	10.0	CHRND, CHRNB1, CHRNG