MCID: LYM022
MIFTS: 54

Lymphangioma malady

Rare diseases, Cancer diseases, Immune diseases categories

Summaries for Lymphangioma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Lymphangiomas are malformations of the lymphatic system, which is the network of vessels responsible for... more...

MalaCards: Lymphangioma, also known as lymphangioma of unspecified site, is related to cystic lymphangioma and hemangioma. An important gene associated with Lymphangioma is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are VEGFR3 signaling in lymphatic endothelium and VEGF Signaling Pathway. The compounds galantamine and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, tongue and colon, and related mouse phenotypes are cardiovascular system and muscle.

Aliases & Classifications for Lymphangioma

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

lymphangioma 9 44 11 46 63
lymphangioma of unspecified site 9
lymphangioma, no icd-o subtype 9
congenital lymphangioma 9
lymphangioma, any site 9
benign lymphangioma 9
lymphangioma nos 9
lymphangiomas 44


External Ids:

Disease Ontology9 DOID:1475
MeSH36 D008202
ICD9CM28 228.1
NCIt41 C8965
ICD1026 D18.1

Related Diseases for Lymphangioma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Lymphangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1cystic lymphangioma31.8CHRND, CHRNG
2hemangioma30.3ACTC1, FLT4, PECAM1
3hemangioendothelioma30.3FLT4
4sarcoma30.2PECAM1, FLT4, ACTC1
5kaposi's sarcoma30.1FLT4, VEGFC, PECAM1
6melanoma29.9PECAM1, VEGFC, FLT4, ACTC1
7seminoma29.8FLT4, VEGFC
8wilms tumor29.8VEGFC, ACTC1
9breast cancer29.6PECAM1, VEGFC, FLT4, ACTC1
10cavernous lymphangioma10.8
11orbital lymphangioma10.7
12mediastinitis10.6
13abdominal cystic lymphangioma10.6
14pancreatitis10.5
15cervicitis10.4
16lymphatic malformation10.4
17microcystic lymphatic malformation10.4
18lymphangiomatosis10.4
19endotheliitis10.3
20hepatitis10.3
21macrocystic lymphatic malformation10.3
22colonic lymphangioma10.2
23diffuse lymphatic malformation10.2
24capillary lymphangioma10.2
25appendicitis10.2
26intussusception10.2
27adenomatoid tumor10.2
28lymphangiectasis10.2
29macroglossia10.2
30primary laryngeal lymphangioma10.2
31tonsillitis10.1
32esophagitis10.1
33laryngitis10.1
34thyroiditis10.1
35cobb syndrome10.1
36hygroma cervical10.1
37weber syndrome10.1
38teratoma10.1
39circumscribed lymphatic malformation10.1
40congenital myasthenic syndrome10.1CHRNG
41lymphedema, congenital10.1FLT4, VEGFC
42multiple pterygium syndrome lethal type10.0CHRNG, CHRND
43lymphedema10.0FLT4, VEGFC
44laryngeal benign neoplasm10.0FLT4, VEGFC
45spindle cell sarcoma10.0ACTC1, FLT4
46laryngeal squamous cell carcinoma10.0VEGFC, FLT4
47medulloblastoma10.0ACTC1
48non-small cell lung carcinoma10.0FLT4, VEGFC
49lymphangiosarcoma10.0
50urethritis10.0

Graphical network of the top 20 diseases related to Lymphangioma:



Diseases related to lymphangioma

Symptoms for Lymphangioma

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Drugs & Therapeutics for Lymphangioma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Lymphangioma

Drug clinical trials:

Search ClinicalTrials for Lymphangioma

Search NIH Clinical Center for Lymphangioma

Search CenterWatch for Lymphangioma

Genetic Tests for Lymphangioma

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Anatomical Context for Lymphangioma

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Sources:
34MalaCards
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MalaCards organs/tissues related to Lymphangioma:

34
Pancreas, Tongue, Colon, Spleen, Breast, Endothelial, Adrenal gland, Ovary, Skin, Thyroid, Tonsil, Bone, Heart, Kidney, Lung, Uterus, T cells, Cervix, Testis, Prostate, Liver, Lymph node, Small intestine, B cells, Retina

Animal Models for Lymphangioma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Lymphangioma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1ACTC1, FLT4, VEGFC, PECAM1
2MP:00053698.1ACTC1, CHRNG, FLT4, PECAM1
3MP:00053767.3PECAM1, VEGFC, FLT4, CHRNG, ACTC1

Publications for Lymphangioma

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53PubMed
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Articles related to Lymphangioma:

(show top 50)    (show all 807)
idTitleAuthorsYear
1
Asymptomatic lymphangioma involving the spleen and mediastinum in adults. (23702506)
2013
2
Lymphangioma circumscriptum of the tongue in children: successful treatment using intralesional bleomycin. (23732020)
2013
3
Complete Resolution of Retroperitoneal Lymphangioma with a Single Trial of OK-432 in an Infant. (24140312)
2013
4
Pericardial cystic lymphangioma. (23034994)
2013
5
Sildenafil for pediatric orbital lymphangioma. (23828510)
2013
6
Combined Mesothelial Cyst and Lymphangioma of the Small Bowel: A Distinct Hybrid Intra-Abdominal Cyst. (24220997)
2013
7
Splenic artery rupture during pregnancy concealed by a pancreatic lymphangioma: a rare co-occurrence. (23088804)
2013
8
Adrenal lymphangioma mimicking renal cyst: a case report and review of the literature. (24303224)
2013
9
Intestinal obstruction complicating a mesenteric cystic lymphangioma. (22795361)
2012
10
Mediastinal lymphangioma treated using endobronchial ultrasound-guided transbronchial needle aspiration. (23018866)
2012
11
Huge cystic lymphangioma of the pancreas mimicking pancreatic cystic neoplasm. (23197988)
2012
12
Robot-assisted laparoscopic removal of perirenal lymphangioma: a case report. (23210414)
2012
13
Lymphangioma: Is intralesional bleomycin sclerotherapy effective? (22279495)
2011
14
Acquired progressive lymphangioma in a 75-year-old man at the site of surgery 22 years previously. (21468468)
2011
15
A case of laparoscopic excision of a huge retroperitoneal cystic lymphangioma. (22606623)
2011
16
Cystic retroperitoneal lymphangioma. (20557520)
2010
17
Lymphangioma circumscriptum. (21048263)
2010
18
Anaesthetic consideration in macroglossia due to lymphangioma of tongue: a case report. (20640084)
2009
19
Solitary hepatic lymphangioma in a 22-day-old infant. (19635291)
2009
20
Vulvar lymphangioma circumscriptum. (19682682)
2009
21
Acquired progressive lymphangioma with atypical clinical presentation. (19171542)
2009
22
Giant lymphangioma of the tongue. (19165040)
2009
23
Lymphangioma circumscriptum of the tongue: successful treatment using intralesional bleomycin. (19545460)
2009
24
Cystic lymphangioma of the breast in a 6-year-old boy. (19853765)
2009
25
Haemorrhage in a scrotal lymphangioma in a child: a rarity. (19661642)
2009
26
Cystic lymphangioma of the gallbladder: report of a case. (18085372)
2008
27
Treatment of lymphangioma in children: our experience of 128 cases. (17270554)
2007
28
Cavernous mesenteric lymphangioma (2006: 4b). (16770656)
2006
29
Prenatal diagnosis of a fetal chest wall cystic lymphangioma using ultrasonography and MRI: a case report with literature review. (16260884)
2005
30
Orbital lymphangioma. (15234158)
2004
31
Abdominal cystic lymphangioma: a rare cause of acute abdomen in a neonate. (11737721)
2001
32
Giant cystic lymphangioma of the stomach. (11841086)
2001
33
Cavernous lymphangioma. (11148532)
2001
34
Immunomodulatory treatment with low-dose interferon-alpha and oral retinoic acid in lymphangioma-like Kaposi's sarcoma. (10769722)
2000
35
Protein-loss into retroperitoneal lymphangioma: demonstration by lymphoscintigraphy and blood-pool scintigraphy with Tc-99m-human serum albumin. (10830532)
2000
36
Abdominal cystic lymphangioma in a woman at 14 weeks' gestation: case report. (11055491)
2000
37
Management of orbital lymphangioma using intralesional injection of OK-432. (10837387)
2000
38
Sotradecol (sodium tetradecyl sulfate) injection of orbital lymphangioma. (10588254)
1999
39
Mediastinal cystic lymphangioma: report of two cases. (9323827)
1997
40
Radiology/pathology conference: mesenteric cystic lymphangioma. (8692443)
1996
41
Abdominal cystic lymphangioma in children: benign lesions that can have a proliferative course. (8861480)
1996
42
Cystic lymphangioma of the transverse colon: report of a case and review of the literature. (8832861)
1996
43
Laparoscopic resection of a retroperitoneal cystic lymphangioma. (7878511)
1994
44
Renal peripelvic lymphatic cysts (lymphangiomas) associated with generalized lymphangiomatosis. (1290204)
1992
45
Case report: MRI and CT comparison of an orbital cavernous lymphangioma. (1753396)
1991
46
Torsion of cavernous lymphangioma: an unusual cause of acute scrotum. (2810511)
1989
47
Hyponatremia resulting from loss of lymphatic fluid in an infant with cystic lymphangioma. (3723245)
1986
48
Sonographic appearance of an abdominal cystic lymphangioma. (6699930)
1984
49
Cystic lymphangioma of the parotid region. (14417246)
1960
50
CYSTIC LYMPHANGIOMA OF THE GREAT OMENTUM. (17863276)
1914

Variations for Lymphangioma

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Expression for genes affiliated with Lymphangioma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphangioma

Search GEO for disease gene expression data for Lymphangioma.

Pathways for genes affiliated with Lymphangioma

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 52PharmGKB, 58SinoBiological, 62Tocris Bioscience, 54QIAGEN, 61Thomson Reuters, 5Cell Signaling Technology, 13EMD Millipore
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Pathways related to Lymphangioma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5VEGFC, FLT4
2
Show member pathways
9.5FLT4, VEGFC
3
Show member pathways
9.5FLT4, VEGFC
4
Show member pathways
9.5FLT4, VEGFC
5
Show member pathways
9.5FLT4, VEGFC
69.5FLT4, VEGFC
7
Show member pathways
VEGFR1 specific signals39
9.5FLT4, VEGFC
89.5CHRNG, CHRND
9
Show member pathways
9.5CHRNG, CHRND
10
Show member pathways
9.1PECAM1, VEGFC
118.7FLT4, VEGFC, PECAM1
12
Show member pathways
8.6VEGFC, FLT4, CHRND, CHRNG
13
Show member pathways
8.6VEGFC, FLT4, CHRND, CHRNG

Compounds for genes affiliated with Lymphangioma

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB
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Compounds related to Lymphangioma according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1galantamine46 52 1211.6CHRND, CHRNG
2hematoxylin469.1ACTC1, PECAM1
3glycosaminoglycan468.9PECAM1, ACTC1
4dexamethasone46 52 30 1211.9ACTC1, FLT4, VEGFC
5formaldehyde46 259.7ACTC1, PECAM1
6ribonucleic acid468.7ACTC1, VEGFC, PECAM1
7glucose468.5ACTC1, VEGFC, PECAM1
8matrigel468.4ACTC1, FLT4, VEGFC, PECAM1
9paraffin468.4PECAM1, VEGFC, FLT4, ACTC1
10vegf468.4PECAM1, VEGFC, FLT4, ACTC1
11oxygen46 259.3ACTC1, FLT4, VEGFC, PECAM1
12estrogen468.3PECAM1, VEGFC, FLT4, ACTC1
13retinoic acid46 259.3PECAM1, VEGFC, FLT4, ACTC1
14tyrosine468.2PECAM1, VEGFC, FLT4, ACTC1

GO Terms for genes affiliated with Lymphangioma

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17Gene Ontology
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Cellular components related to Lymphangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:0058929.4CHRNG, CHRND
2extracellular spaceGO:0056158.5ACTC1, VEGFC, PECAM1
3cell junctionGO:0300548.4CHRNG, CHRND, PECAM1

Biological processes related to Lymphangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor receptor signaling pathwayGO:0480109.5FLT4, VEGFC
2muscle contractionGO:0069369.5CHRNG, CHRND
3regulation of membrane potentialGO:0423919.4CHRND, CHRNG
4platelet degranulationGO:0025768.8VEGFC, PECAM1
5signal transductionGO:0071658.2CHRNG, CHRND, VEGFC, PECAM1

Molecular functions related to Lymphangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-activated cation-selective channel activityGO:0048899.5CHRNG, CHRND

Products for genes affiliated with Lymphangioma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphangioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet