MCID: LYM022
MIFTS: 57

Lymphangioma malady

Cancer diseases, Immune diseases categories

Summaries for Lymphangioma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Lymphangiomas are malformations of the lymphatic system, which is the network of vessels responsible for... more...

MalaCards: Lymphangioma, also known as lymphangioma of unspecified site, is related to cystic lymphangioma and hemangioma. An important gene associated with Lymphangioma is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are Signaling by VEGF and Presynaptic nicotinic acetylcholine receptors. The compounds galantamine and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include pancreas, tongue and spleen, and related mouse phenotypes are respiratory system and muscle.

Aliases & Classifications for Lymphangioma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

lymphangioma 8 42 10 44 60
lymphangioma of unspecified site 8
lymphangioma, no icd-o subtype 8
congenital lymphangioma 8
lymphangioma, any site 8
benign lymphangioma 8
lymphangioma nos 8
lymphangiomas 42


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Disease Ontology8 DOID:1475
MeSH34 D008202
NCIt39 C8965
ICD9CM27 228.1
ICD1025 D18.1

Related Diseases for Lymphangioma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lymphangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1cystic lymphangioma31.6AFP, CHRNG, CHRND, MAST4, HIRA, EIF3M
2hemangioma30.3PDPN, FLT4, PROX1, CD34, ACTC1, PECAM1
3sarcoma30.2PECAM1, ACTC1, CD34, FLT4
4kaposi's sarcoma30.1CD34
5lymphangiosarcoma29.9PROX1
6melanoma29.9PDPN, FLT4, VEGFC, CD34, ACTC1, PTCH1
7peritonitis29.7PECAM1
8capillary hemangioma29.7CD34
9hydrocele29.7FLT4
10epithelioid hemangioendothelioma29.7FLT4, CD34
11seminoma29.7PDPN, FLT4, AFP, VEGFC
12glioblastoma multiforme29.7PECAM1, PTCH1, VEGFC, FLT4, PDPN
13breast cancer29.7LYVE1, PECAM1, PTCH1, ACTC1, VEGFC, FLT4
14squamous cell carcinoma29.7PDPN, FLT4, VEGFC, CD34, ACTC1, PTCH1
15mediastinitis10.5
16colonic lymphangioma10.5
17pancreatitis10.5
18cervicitis10.4
19abdominal cystic lymphangioma10.3
20hepatitis10.3
21microcystic lymphatic malformation10.2
22macrocystic lymphatic malformation10.2
23capillary lymphangioma10.2
24hepatitis a10.2
25diffuse lymphatic malformation10.2
26klippel-trenaunay syndrome10.1
27intussusception10.1
28appendicitis10.1
29adenomatoid tumor10.1
30cavernous lymphangioma10.1
31lymphatic malformation10.1
32tonsillitis10.1
33esophagitis10.1
34laryngitis10.1
35thyroiditis10.1
36hygroma cervical10.1
37orbital lymphangioma10.1
38circumscribed lymphatic malformation10.1
39hemangioblastoma10.0PDPN
40fetal akinesia deformation sequence10.0RAPSN
41oligohydramnios10.0AFP
42nicotine dependence10.0CHRNB1
43adenoma10.0ACTC1, FLT4
44hemangioendothelioma10.0CD34, FLT4
45multiple pterygium syndrome lethal type10.0CHRNG, CHRND
46malignant mesothelioma10.0FLT4, PDPN
47slow-channel congenital myasthenic syndrome10.0CHRND, CHRNB1
48congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.0CHRNB1, RAPSN
49spindle cell sarcoma10.0FLT4, ACTC1
50gallbladder cancer10.0PDPN

Graphical network of the top 20 diseases related to Lymphangioma:



Diseases related to lymphangioma

Clinical Features for Lymphangioma

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Drugs & Therapeutics for Lymphangioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lymphangioma

Drug clinical trials:

Search ClinicalTrials for Lymphangioma

Search NIH Clinical Center for Lymphangioma

Search CenterWatch for Lymphangioma

Genetic Tests for Lymphangioma

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Anatomical Context for Lymphangioma

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32MalaCards
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MalaCards organs/tissues related to Lymphangioma:

32
Pancreas, Tongue, Spleen, Colon, Breast, Endothelial, Adrenal gland, Ovary, Skin, Tonsil, Thyroid, Kidney, Uterus, Bone, Heart, Lung, Lymph node, B cells, T cells, Liver, Cervix, Testis, Prostate, Small intestine, Retina

Animal Models for Lymphangioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lymphangioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.4PROX1, CHRNG, RAPSN, PTCH1, PECAM1, PDPN
2MP:00053699.4PDPN, FLT4, CHRNG, RAPSN, ACTC1, PTCH1
3MP:00053858.7LYVE1, PDPN, FLT4, PROX1, VEZF1, VEGFC
4MP:00053878.5PDPN, FLT4, PROX1, VEZF1, VEGFC, HIRA
5MP:00107688.4PDPN, FLT4, PROX1, AFP, CHRNG, VEZF1
6MP:00053768.3AFP, PROX1, FLT4, PDPN, CHRNG, VEGFC

Publications for Lymphangioma

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50PubMed
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Articles related to Lymphangioma:

(show top 50)    (show all 818)
idTitleAuthorsYear
1
Combined Mesothelial Cyst and Lymphangioma of the Small Bowel: A Distinct Hybrid Intra-Abdominal Cyst. (24220997)
2013
2
Intra-oral lymphangioma successfully treated using fractional carbon dioxide laser. (23433173)
2013
3
Retroperitoneal cystic lymphangioma: a diagnostic and surgical challenge. (23533897)
2013
4
Solitary cystic mediastinal lymphangioma. (23457171)
2013
5
Non-contrast 3D MR lymphography of retroperitoneal lymphatic aneurysmal dilatation: a continuous spectrum of change from normal variants to cystic lymphangioma. (24127269)
2013
6
Giant cavernous mesenteric lymphangioma in adult. (22585680)
2013
7
Mediastinal lymphangioma treated using endobronchial ultrasound-guided transbronchial needle aspiration. (23018866)
2012
8
Cystic pancreatic lymphangioma. (22826784)
2012
9
Giant cystic lymphangioma of the mesentery: varied clinical presentation of 3 cases. (22826732)
2012
10
Acquired scrotal lymphangioma successfully treated using carbon dioxide laser ablation. (21388486)
2011
11
Orbital teratoma masquerading as lymphangioma. (21907123)
2011
12
Cystic pancreatic lymphangioma. The first report of a preoperative pathological diagnosis by endoscopic ultrasound-guided cyst aspiration. (21904074)
2011
13
Retiform hemangioendothelioma developed on the site of an earlier cystic lymphangioma in a six-year-old girl. (21915027)
2011
14
Endoscope-assisted excision of macrocystic lymphangioma in neck via anterior chest approach in infants and children. (21802152)
2011
15
Identification of equine cutaneous lymphangioma by application of a lymphatic endothelial cell marker. (20042195)
2010
16
Vulvar lymphangioma circumscriptum presenting periodic symptoms. (22802470)
2010
17
Bleomycin sclerotherapy in a rare case of adult-onset cervical lymphangioma. (20155685)
2010
18
A rare cause of acute appendicitis: cystic lymphangioma. (21396267)
2010
19
Iron deficiency anaemia: an unusual presentation of lymphangioma. (20666776)
2010
20
Clinical challenges and images in GI. Diagnosis: Cavernous lymphangioma of the jejunum. (19254683)
2009
21
Acquired omental cystic lymphangioma after subtotal gastrectomy: a case report. (19949686)
2009
22
Laparoscopic treatment of a huge cystic lymphangioma: partial aspiration technique with a spinal needle. (18721013)
2008
23
Cystic lymphangioma of the pancreas. (17368224)
2007
24
Intralesional injection of OK-432 for vision-threatening orbital lymphangioma. (17577592)
2007
25
Acquired lymphangioma circumscriptum of the vulva. (18319007)
2007
26
Cystic lymphangioma of the mesentery causing intestinal obstruction. (17909661)
2007
27
Establishment of lymphangioma model and a study on the promoting effect of murine melanoma cell B16-F1 on the lymphangiogenesis in vitro. (18231756)
2007
28
A case of cardiac lymphangioma presenting as a cystic mass in the right atrium. (18159600)
2007
29
Giant lymphangioma circumscriptum mimicking wart in a 13-year-old girl. (16848827)
2006
30
Cystic lymphangioma arising in the tip of the tongue in an adult. (16185846)
2006
31
TIE2 gain-of-function mutation in a patient with pancreatic lymphangioma associated with blue rubber-bleb nevus syndrome: report of a case. (16493543)
2006
32
Cystic lymphangioma of the upper extremity: US and MRI correlation (2004:11b). (15756720)
2005
33
Histopathological study of orbital lymphangioma in an infant. (15592788)
2004
34
A case of orbital lymphangioma showing considerable shrinkage after limiting dissection. (15043553)
2004
35
The association of jejunal atresia and cystic lymphangioma in the same location. (12891508)
2003
36
A role of cytokines in OK-432 injection therapy for cystic lymphangioma: an approach to the mechanism. (14666473)
2003
37
Prenatal ultrasonographic findings of intra-abdominal cystic lymphangioma: a case report. (9142629)
1997
38
Retroperitoneal cystic lymphangioma: report of one case. (9297935)
1997
39
Cavernous lymphangioma presenting as a vaginal discharge in a six-year-old female: a case report. (9551374)
1996
40
Mesenteric cystic lymphangioma with myxoid degeneration: unusual CT and MR manifestations. (8545181)
1995
41
Prenatal diagnosis and management of massive bilateral axillary cystic lymphangioma. (7724136)
1995
42
Prenatal diagnosis of cavernous lymphangioma of the arm. (12796903)
1993
43
Prenatal ultrasonic diagnosis of retroperitoneal cystic lymphangioma. (8355339)
1993
44
Mixed hemangioma and cystic lymphangioma of the esophagus in a child. (1403466)
1992
45
Retroperitoneal cystic lymphangioma: MR findings. (2325521)
1990
46
Cavernous lymphangioma of the vulva. (2704522)
1989
47
Hyponatremia resulting from loss of lymphatic fluid in an infant with cystic lymphangioma. (3723245)
1986
48
Congenital virilizing adrenal hyperplasia, segmental hypertrophy, macrodactyly, and cystic lymphangioma. (671179)
1978
49
Retroperitoneal cystic lymphangioma. (13981295)
1963
50
Cystic lymphangioma of the mesentery; review of the literature and report of a case. (13487066)
1958

Genetic Variations for Lymphangioma

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Expression for genes affiliated with Lymphangioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphangioma

Search GEO for disease gene expression data for Lymphangioma.

Pathways for genes affiliated with Lymphangioma

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53Reactome, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN
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Compounds for genes affiliated with Lymphangioma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Lymphangioma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1galantamine44 49 1112.3CHRNB1, CHRND, CHRNG
2sialic acid4410.3PECAM1
3b 7234410.2PDPN, AFP, ACTC1
4p0054410.1AFP, PECAM1, LYVE1
5matrigel4410.0PECAM1, ACTC1, VEGFC, FLT4
6hematoxylin4410.0PDPN, CD34, ACTC1, PECAM1
7glycosaminoglycan449.8LYVE1, PECAM1, ACTC1
8reticulin449.8ACTC1, CD34
9thymidine44 2410.6AFP, VEGFC, CD34, PECAM1, LYVE1
10progesterone44 59 28 11 2413.5AFP, VEGFC, CD34, ACTC1, LYVE1
11retinoic acid44 2410.5FLT4, AFP, VEGFC, CD34, ACTC1, PECAM1
12estrogen449.4FLT4, AFP, VEGFC, CD34, ACTC1, PECAM1
13tyrosine449.2PDPN, FLT4, AFP, VEGFC, CD34, RAPSN
14paraffin449.1LYVE1, PDPN, FLT4, AFP, VEGFC, CD34
15vegf449.1PDPN, FLT4, PROX1, AFP, VEGFC, CD34

GO Terms for genes affiliated with Lymphangioma

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16Gene Ontology
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Cellular components related to Lymphangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.1CHRNB1, CHRND, CHRNG
2postsynaptic membraneGO:0452119.8CHRNG, CHRND, CHRNB1, RAPSN
3cell junctionGO:0300549.7CHRNG, CHRND, CHRNB1, RAPSN, PECAM1
4integral to plasma membraneGO:0058879.4FLT4, CHRNG, CHRNB1, CD34, LYVE1, PDPN
5plasma membraneGO:0058868.4PDPN, OR5K1, FLT4, CHRNG, CHRND, CD34

Biological processes related to Lymphangioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, cholinergicGO:00727110.2RAPSN, CHRNB1
2glomerular endothelium developmentGO:07201110.1PECAM1, CD34
3lymphangiogenesisGO:00194610.1PROX1, FLT4, PDPN
4skeletal muscle thin filament assemblyGO:03024010.1ACTC1, PROX1
5regulation of membrane potentialGO:04239110.0CHRNG, CHRND, CHRNB1
6transportGO:0068109.8AFP, CHRNG, CHRND, CLIC2, LYVE1
7muscle contractionGO:0069369.8CHRNB1, CHRND, CHRNG
8signal transductionGO:0071659.3PDPN, CHRNG, CHRND, CHRNB1, VEGFC, CD34

Molecular functions related to Lymphangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine receptor activityGO:01546410.2CHRNB1, CHRNG
2channel activityGO:01526710.1CHRNB1, CHRNG
3acetylcholine-activated cation-selective channel activityGO:00488910.1CHRNB1, CHRND, CHRNG
4acetylcholine bindingGO:0421669.9CHRNB1, CHRND

Products for genes affiliated with Lymphangioma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphangioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet