MCID: LYM022
MIFTS: 46

Lymphangioma malady

Rare diseases, Cancer diseases, Immune diseases categories

Aliases & Classifications for Lymphangioma

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Lymphangioma, Aliases & Descriptions:

Name: Lymphangioma 9 41 11 43 60
Congenital Lymphangioma 9
 
Benign Lymphangioma 9
Lymphangiomas 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology9 DOID:1475
ICD9CM27 228.1
NCIt38 C8965
MeSH33 D008202
ICD1025 D18.1

Summaries for Lymphangioma

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NIH Rare Diseases:41 Lymphangioma is a benign (non-cancerous) mass made of fluid-filled spaces, which is thought to occur due to abnormal development of the lymphatic system. they are always present at birth, although they may change and become more apparent over time. lymphangiomas are most commonly found in the head and neck region, but can affect almost any part of the body (except the brain). some may appear as a tiny blue or red spot while others are massive and affect an entire limb (arm or leg). the signs and symptoms vary depending on the size and location of the mass; however, lymphangiomas can disfigure affected areas and potentially disrupt the function of nearby organs or tissues regardless of size. the exact underlying cause is unknown. treatment options vary based on the signs and symptoms present in each person but may include surgery. last updated: 12/20/2014

MalaCards based summary: Lymphangioma, also known as congenital lymphangioma, is related to cystic lymphangioma and hemangioendothelioma. An important gene associated with Lymphangioma is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are VEGFR3 signaling in lymphatic endothelium and VEGF Signaling Pathway. The compounds galantamine and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lymph node and brain, and related mouse phenotypes are cardiovascular system and muscle.

Wikipedia:63 Lymphangiomas are malformations of the lymphatic system characterized by lesions that are thin-walled... more...

Related Diseases for Lymphangioma

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Diseases related to Lymphangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1cystic lymphangioma32.0CHRND, CHRNG
2hemangioendothelioma30.8FLT4
3hemangioma30.2ACTC1, FLT4, PECAM1
4seminoma30.0FLT4, VEGFC
5sarcoma30.0PECAM1, FLT4, ACTC1
6mesothelioma29.9ACTC1, PECAM1
7kaposi sarcoma29.8FLT4, VEGFC, PECAM1
8wilms tumor29.8VEGFC, ACTC1
9glioblastoma29.5FLT4, VEGFC, PECAM1
10melanoma29.4PECAM1, VEGFC, FLT4, ACTC1
11breast cancer29.2PECAM1, VEGFC, FLT4, ACTC1
12cavernous lymphangioma10.8
13orbital lymphangioma10.7
14mediastinitis10.6
15abdominal cystic lymphangioma10.6
16pancreatitis10.5
17cervicitis10.4
18congenital myasthenic syndrome10.4CHRNG
19lymphangiomatosis10.4
20microcystic lymphatic malformation10.4
21hepatitis10.3
22macrocystic lymphatic malformation10.3
23colonic lymphangioma10.3
24endotheliitis10.3
25capillary lymphangioma10.2
26appendicitis10.2
27primary laryngeal lymphangioma10.2
28diffuse lymphatic malformation10.2
29lymphedema, congenital10.2FLT4, VEGFC
30multiple pterygium syndrome, lethal type10.2CHRNG, CHRND
31lymphedema10.2FLT4, VEGFC
32laryngeal carcinoma10.2FLT4, VEGFC
33klippel-trenaunay-weber syndrome10.2
34intussusception10.2
35adenomatoid tumor10.2
36cobb syndrome10.2
37lymphangiectasis10.2
38macroglossia10.2
39spindle cell sarcoma10.2ACTC1, FLT4
40laryngeal squamous cell carcinoma10.2VEGFC, FLT4
41medulloblastoma10.1ACTC1
42proteus syndrome, somatic10.1
43tonsillitis10.1
44duodenitis10.1
45esophagitis10.1
46laryngitis10.1
47thyroiditis10.1
48weber syndrome10.1
49teratoma10.1
50circumscribed lymphatic malformation10.1

Graphical network of the top 20 diseases related to Lymphangioma:



Diseases related to lymphangioma

Symptoms for Lymphangioma

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Drugs & Therapeutics for Lymphangioma

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Drug clinical trials:

Search ClinicalTrials for Lymphangioma

Search NIH Clinical Center for Lymphangioma

Genetic Tests for Lymphangioma

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Anatomical Context for Lymphangioma

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MalaCards organs/tissues related to Lymphangioma:

31
Pancreas, Lymph node, Brain, Tongue, Spleen, Colon, Breast, Adrenal gland, Endothelial, Skin, Ovary, Thyroid, Tonsil, Bone, Heart, Kidney, Liver, Lung, Uterus, Retina, Small intestine, Prostate, Testis, Cervix, T cells, B cells

Animal Models for Lymphangioma or affiliated genes

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MGI Mouse Phenotypes related to Lymphangioma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1ACTC1, FLT4, VEGFC, PECAM1
2MP:00053698.1ACTC1, CHRNG, FLT4, PECAM1
3MP:00053767.3PECAM1, VEGFC, FLT4, CHRNG, ACTC1

Publications for Lymphangioma

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Articles related to Lymphangioma:

(show top 50)    (show all 871)
idTitleAuthorsYear
1
Coexisting pancreatic mucinous cyst adenoma and adrenal lymphangioma. (25224209)
2014
2
Cystic lymphangioma of the chest wall: a case report. (25606029)
2014
3
Unusual sites of cystic lymphangioma in children. (25282458)
2014
4
Asymptomatic lymphangioma involving the spleen and mediastinum in adults. (23702506)
2013
5
Lymphangioma circumscriptum of the tongue in children: successful treatment using intralesional bleomycin. (23732020)
2013
6
Complete Resolution of Retroperitoneal Lymphangioma with a Single Trial of OK-432 in an Infant. (24140312)
2013
7
Pericardial cystic lymphangioma. (23034994)
2013
8
Sildenafil for pediatric orbital lymphangioma. (23828510)
2013
9
Combined Mesothelial Cyst and Lymphangioma of the Small Bowel: A Distinct Hybrid Intra-Abdominal Cyst. (24220997)
2013
10
Splenic artery rupture during pregnancy concealed by a pancreatic lymphangioma: a rare co-occurrence. (23088804)
2013
11
Intestinal obstruction complicating a mesenteric cystic lymphangioma. (22795361)
2012
12
Mediastinal lymphangioma treated using endobronchial ultrasound-guided transbronchial needle aspiration. (23018866)
2012
13
Huge cystic lymphangioma of the pancreas mimicking pancreatic cystic neoplasm. (23197988)
2012
14
Robot-assisted laparoscopic removal of perirenal lymphangioma: a case report. (23210414)
2012
15
Lymphangioma: Is intralesional bleomycin sclerotherapy effective? (22279495)
2011
16
Acquired progressive lymphangioma in a 75-year-old man at the site of surgery 22 years previously. (21468468)
2011
17
Cystic retroperitoneal lymphangioma. (20557520)
2010
18
Lymphangioma circumscriptum. (21048263)
2010
19
Anaesthetic consideration in macroglossia due to lymphangioma of tongue: a case report. (20640084)
2009
20
Solitary hepatic lymphangioma in a 22-day-old infant. (19635291)
2009
21
Vulvar lymphangioma circumscriptum. (19682682)
2009
22
Acquired progressive lymphangioma with atypical clinical presentation. (19171542)
2009
23
Giant lymphangioma of the tongue. (19165040)
2009
24
Lymphangioma circumscriptum of the tongue: successful treatment using intralesional bleomycin. (19545460)
2009
25
Cystic lymphangioma of the breast in a 6-year-old boy. (19853765)
2009
26
Haemorrhage in a scrotal lymphangioma in a child: a rarity. (19661642)
2009
27
Cystic lymphangioma of the gallbladder: report of a case. (18085372)
2008
28
Treatment of lymphangioma in children: our experience of 128 cases. (17270554)
2007
29
Cavernous mesenteric lymphangioma (2006: 4b). (16770656)
2006
30
Prenatal diagnosis of a fetal chest wall cystic lymphangioma using ultrasonography and MRI: a case report with literature review. (16260884)
2005
31
Orbital lymphangioma. (15234158)
2004
32
Abdominal cystic lymphangioma: a rare cause of acute abdomen in a neonate. (11737721)
2001
33
Giant cystic lymphangioma of the stomach. (11841086)
2001
34
Cavernous lymphangioma. (11148532)
2001
35
Immunomodulatory treatment with low-dose interferon-alpha and oral retinoic acid in lymphangioma-like Kaposi's sarcoma. (10769722)
2000
36
Protein-loss into retroperitoneal lymphangioma: demonstration by lymphoscintigraphy and blood-pool scintigraphy with Tc-99m-human serum albumin. (10830532)
2000
37
Abdominal cystic lymphangioma in a woman at 14 weeks' gestation: case report. (11055491)
2000
38
Management of orbital lymphangioma using intralesional injection of OK-432. (10837387)
2000
39
Sotradecol (sodium tetradecyl sulfate) injection of orbital lymphangioma. (10588254)
1999
40
Mediastinal cystic lymphangioma: report of two cases. (9323827)
1997
41
Radiology/pathology conference: mesenteric cystic lymphangioma. (8692443)
1996
42
Abdominal cystic lymphangioma in children: benign lesions that can have a proliferative course. (8861480)
1996
43
Cystic lymphangioma of the transverse colon: report of a case and review of the literature. (8832861)
1996
44
Laparoscopic resection of a retroperitoneal cystic lymphangioma. (7878511)
1994
45
Case report: MRI and CT comparison of an orbital cavernous lymphangioma. (1753396)
1991
46
Torsion of cavernous lymphangioma: an unusual cause of acute scrotum. (2810511)
1989
47
Hyponatremia resulting from loss of lymphatic fluid in an infant with cystic lymphangioma. (3723245)
1986
48
Sonographic appearance of an abdominal cystic lymphangioma. (6699930)
1984
49
Cystic lymphangioma of the parotid region. (14417246)
1960
50
CYSTIC LYMPHANGIOMA OF THE GREAT OMENTUM. (17863276)
1914

Variations for Lymphangioma

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Expression for genes affiliated with Lymphangioma

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Search GEO for disease gene expression data for Lymphangioma.

Pathways for genes affiliated with Lymphangioma

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Pathways related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5VEGFC, FLT4
2
Show member pathways
9.5FLT4, VEGFC
3
Show member pathways
9.5FLT4, VEGFC
4
Show member pathways
9.5FLT4, VEGFC
5
Show member pathways
9.5FLT4, VEGFC
69.5FLT4, VEGFC
7
Show member pathways
VEGFR1 specific signals36
9.5FLT4, VEGFC
8
Show member pathways
9.5CHRNG, CHRND
9
Show member pathways
9.1PECAM1, VEGFC
108.7FLT4, VEGFC, PECAM1
11
Show member pathways
8.6VEGFC, FLT4, CHRND, CHRNG
12
Show member pathways
8.6VEGFC, FLT4, CHRND, CHRNG

Compounds for genes affiliated with Lymphangioma

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Sources:
43Novoseek, 49PharmGKB, 12DrugBank, 28IUPHAR, 24HMDB
See all sources

Compounds related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 14)
idCompoundScoreTop Affiliating Genes
1galantamine43 49 1211.6CHRND, CHRNG
2hematoxylin439.1ACTC1, PECAM1
3glycosaminoglycan438.9PECAM1, ACTC1
4dexamethasone43 49 28 1211.9ACTC1, FLT4, VEGFC
5formaldehyde43 249.7ACTC1, PECAM1
6ribonucleic acid438.7ACTC1, VEGFC, PECAM1
7glucose438.5ACTC1, VEGFC, PECAM1
8matrigel438.4ACTC1, FLT4, VEGFC, PECAM1
9paraffin438.4PECAM1, VEGFC, FLT4, ACTC1
10vegf438.4PECAM1, VEGFC, FLT4, ACTC1
11oxygen43 249.3ACTC1, FLT4, VEGFC, PECAM1
12estrogen438.3PECAM1, VEGFC, FLT4, ACTC1
13retinoic acid43 249.3PECAM1, VEGFC, FLT4, ACTC1
14tyrosine438.2PECAM1, VEGFC, FLT4, ACTC1

GO Terms for genes affiliated with Lymphangioma

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Cellular components related to Lymphangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00058929.4CHRNG, CHRND
2extracellular spaceGO:00056158.5ACTC1, VEGFC, PECAM1
3cell junctionGO:00300548.4CHRNG, CHRND, PECAM1

Biological processes related to Lymphangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor receptor signaling pathwayGO:00480109.5FLT4, VEGFC
2muscle contractionGO:00069369.5CHRNG, CHRND
3regulation of membrane potentialGO:00423919.4CHRND, CHRNG
4platelet degranulationGO:00025768.8VEGFC, PECAM1
5signal transductionGO:00071658.2CHRNG, CHRND, VEGFC, PECAM1

Molecular functions related to Lymphangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-activated cation-selective channel activityGO:00048899.5CHRNG, CHRND

Products for genes affiliated with Lymphangioma

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Sources for Lymphangioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet