MCID: LYM022
MIFTS: 51

Lymphangioma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Lymphangioma

MalaCards integrated aliases for Lymphangioma:

Name: Lymphangioma 12 29 52 42 14 69
Congenital Lymphangioma 12
Benign Lymphangioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1475
ICD10 33 D18.1
ICD9CM 35 228.1
MeSH 42 D008202
NCIt 47 C8965
UMLS 69 C0024221

Summaries for Lymphangioma

MalaCards based summary : Lymphangioma, also known as congenital lymphangioma, is related to lymphangiosarcoma and cystic lymphangioma. An important gene associated with Lymphangioma is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Picibanil and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, tongue and lymph node, and related phenotypes are Decreased cell migration and cardiovascular system

Wikipedia : 72 Lymphangiomas are malformations of the lymphatic system characterized by lesions that are thin-walled... more...

Related Diseases for Lymphangioma

Diseases related to Lymphangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
id Related Disease Score Top Affiliating Genes
1 lymphangiosarcoma 29.9 ACTC1 VIM
2 cystic lymphangioma 12.2
3 abdominal cystic lymphangioma 12.2
4 microcystic lymphatic malformation 12.0
5 capillary lymphangioma 11.9
6 colonic lymphangioma 11.9
7 cavernous lymphangioma 11.9
8 orbital lymphangioma 11.9
9 lymphatic malformations 11.9
10 primary laryngeal lymphangioma 11.9
11 cobb syndrome 11.2
12 nuchal bleb, familial 11.1
13 vascular malformation 11.1
14 mixed cystic lymphatic malformation 11.1
15 diffuse lymphatic malformation 10.9
16 infantile myofibromatosis 10.8
17 organic mood syndrome 10.8 FLT4 PDPN
18 papillary meningioma of the cerebellum 10.7 FLT4 PDPN
19 hemi 3 syndrome 10.7 FLT4 KDR
20 hemangioma, capillary infantile 10.7 FLT4 KDR
21 hypertonia 10.7 FLT4 VEGFA
22 epidural neoplasm 10.6 VEGFA VEGFC
23 kidney pelvis papillary carcinoma 10.6 KDR VEGFA
24 aids wasting syndrome 10.5 IFNA2 PDPN
25 waterhouse-friderichsen syndrome 10.5 FLT4 VEGFA
26 iliac vein thrombophlebitis 10.5 KDR VEGFA
27 segmental odontomaxillary dysplasia 10.5 KDR VEGFA
28 thymus adenocarcinoma 10.5 PDPN PROX1
29 coloboma of superior eyelid 10.5 KDR VEGFA
30 punctate palmoplantar keratoderma type 2 10.5 ACTC1 KDR
31 hyperlucent lung 10.5 FLT4 PROX1
32 lens disease 10.5 KDR VEGFA
33 congenital mitral stenosis 10.5 FLT4 PDPN VEGFC
34 pyruvate kinase deficiency, muscle type 10.4 ACTC1 VEGFA
35 alcohol-induced mental disorder 10.4 KDR VIM
36 posterior foramen magnum meningioma 10.4 KDR VEGFA
37 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 10.4 KDR VEGFA
38 hemangioma 10.4
39 lymphocytic hypophysitis 10.4 ACTC1 VIM
40 carcinoma of unknown primary site, childhood 10.4 IFNA2 VEGFA
41 gastric signet ring cell adenocarcinoma 10.4 ACTC1 VIM
42 aortic aneurysm 10.4 ACTC1 VIM
43 esophagus leiomyosarcoma 10.4 ACTC1 VIM
44 spleen angiosarcoma 10.4 ACTC1 VIM
45 myoma 10.4 ACTC1 VIM
46 skin lipoma 10.3 ACTC1 VIM
47 phlegmonous dacryocystitis 10.3 KDR VEGFA
48 laryngeal neuroendocrine tumor 10.3 ACTC1 VIM
49 myxoid leiomyosarcoma 10.3 ACTC1 VIM
50 berk-tabatznik syndrome 10.3 ACTC1 VIM

Graphical network of the top 20 diseases related to Lymphangioma:



Diseases related to Lymphangioma

Symptoms & Phenotypes for Lymphangioma

GenomeRNAi Phenotypes related to Lymphangioma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 8.92 KDR PIK3CA VEGFC VIM

MGI Mouse Phenotypes related to Lymphangioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 ACTC1 FLT4 KDR PDPN PIK3CA PROX1
2 homeostasis/metabolism MP:0005376 9.97 ACTC1 FLT4 KDR PDPN PIK3CA PROX1
3 immune system MP:0005387 9.91 FLT4 KDR PDPN PIK3CA PROX1 SERPINF1
4 mortality/aging MP:0010768 9.81 VEGFC VIM ACTC1 FLT4 KDR PDPN
5 muscle MP:0005369 9.5 PDPN PIK3CA VEGFA VIM ACTC1 FLT4
6 vision/eye MP:0005391 9.1 KDR PIK3CA PROX1 SERPINF1 VEGFA VIM

Drugs & Therapeutics for Lymphangioma

Drugs for Lymphangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Picibanil Phase 2, Phase 3
2
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
3
Everolimus Approved Phase 2 159351-69-6 6442177
4
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
5
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
6 Phosphodiesterase 5 Inhibitors Phase 1, Phase 2
7 Phosphodiesterase Inhibitors Phase 1, Phase 2
8 Sildenafil Citrate Phase 1, Phase 2 171599-83-0
9 Vasodilator Agents Phase 1, Phase 2
10 Antineoplastic Agents, Hormonal Phase 2
11 Gastrointestinal Agents Phase 2
12 Anti-Bacterial Agents Phase 2
13 Antibiotics, Antitubercular Phase 2
14 Antifungal Agents Phase 2
15 Anti-Infective Agents Phase 2
16 Immunosuppressive Agents Phase 2
17 Citrate Nutraceutical Phase 1, Phase 2
18
Citric Acid Nutraceutical, Vet_approved Phase 1, Phase 2 77-92-9 311
19
Marimastat Approved, Investigational Phase 1 154039-60-8 119031
20
Selenium Approved, Vet_approved Phase 1 7782-49-2
21 Antioxidants Phase 1
22 Micronutrients Phase 1
23 Protective Agents Phase 1
24 Trace Elements Phase 1
25
Pancrelipase Approved Early Phase 1 53608-75-6
26 pancreatin Early Phase 1
27 Anesthetics

Interventional clinical trials:

(show all 17)

id Name Status NCT ID Phase Drugs
1 Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations Completed NCT00010452 Phase 2, Phase 3 picibanil
2 A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations Completed NCT01290484 Phase 1, Phase 2 Sildenafil
3 Sildenafil for the Treatment of Lymphatic Malformations Recruiting NCT02335242 Phase 2 Sildenafil 20 mg tablets
4 Trial of Taselisib in Overgrowth Recruiting NCT03290092 Phase 1, Phase 2 Taselisib (GDC0032);Taselisib (GDC0032)
5 Octreotide VS Placebo in Prevention of Salivary Fistulae After Post Radiation Salvage Surgery Recruiting NCT02437825 Phase 2 octreotide
6 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2 sirolimus
7 Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations Not yet recruiting NCT03243019 Phase 2 rapamycin
8 Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options. Completed NCT00261391 Phase 1 Marimastat
9 Selenium in the Treatment of Complicated Lymphatic Malformations Terminated NCT01212965 Phase 1 Selenium
10 Needle-based Confocal Laser Endomicroscopy on Pancreatic Cystic Lesions Unknown status NCT02494388 Early Phase 1
11 Diagnosis of Hemangiomas and Vascular Malformations Completed NCT00577213
12 Lymphatic Anomalies Registry Recruiting NCT02399527
13 AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome) Recruiting NCT02250456
14 Registry for Vascular Anomalies Associated With Coagulopathy Recruiting NCT00576888
15 Airway Vascular Lesions Active, not recruiting NCT00866827
16 Imaging of Lymphatic Anomalies Enrolling by invitation NCT02744027
17 Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders Enrolling by invitation NCT00833599 NIRFLI with ICG

Search NIH Clinical Center for Lymphangioma

Cochrane evidence based reviews: lymphangioma

Genetic Tests for Lymphangioma

Genetic tests related to Lymphangioma:

id Genetic test Affiliating Genes
1 Lymphangioma 29

Anatomical Context for Lymphangioma

MalaCards organs/tissues related to Lymphangioma:

39
Pancreas, Tongue, Lymph Node, Colon, Spleen, Breast, Endothelial

Publications for Lymphangioma

Articles related to Lymphangioma:

(show top 50) (show all 1005)
id Title Authors Year
1
Management of a large cystic lymphangioma causing intestinal obstruction. ( 28477401 )
2017
2
Acquired progressive lymphangioma: Case report with partial response to imiquimod 5% cream. ( 28940760 )
2017
3
Imaging findings of axillary cystic lymphangioma in adult. ( 28735807 )
2017
4
Pancreatic Lymphangioma: A Diagnostic and Treatment Dilemma. ( 28738930 )
2017
5
Cystic lymphangioma of spleen in adults. ( 28122799 )
2017
6
Treatment of Tongue Lymphangioma with Intralesional Combination Injection of Steroid, Bleomycin and Bevacizumab. ( 28913305 )
2017
7
Mixed Lymphangioma and Cavernous Hemangioma Within the Ulnar Nerve: A Case Report. ( 28391718 )
2017
8
Small bowel volvulus in an adult with mesenteric lymphangioma and ascariasis. ( 28266164 )
2017
9
Small Intestinal Lymphangioma Presenting as an Acute Abdomen with Relevant Review of Literature. ( 28764241 )
2017
10
Microbubbles in macrocysts - Contrast-enhanced ultrasound assisted sclerosant therapy of a congenital macrocystic lymphangioma: a case report. ( 28683719 )
2017
11
Abdominal cystic lymphangioma in a term newborn: A case report and update of new treatments. ( 28225486 )
2017
12
Axillary lymphangioma in an asymptomatic adult female. ( 28877380 )
2017
13
Incidental finding of (131)I uptake in mesenteric cystic lymphangioma on post-therapy (131)I SPECT/CT imaging. ( 28215398 )
2017
14
Cystic Lymphangioma of the Colon: Endoscopic Removal beyond the Frontiers of Size. ( 28512390 )
2017
15
Vulvar lymphangioma circumscriptum: comparison of primary and acquired forms in a cohort of 57 patients. ( 28758249 )
2017
16
Lymphangioma-like classic Kaposi sarcoma. ( 28188608 )
2017
17
An acute presentation of pediatric mesenteric lymphangioma: a case report and literature overview. ( 28927352 )
2017
18
A prospective study of the role of intralesional bleomycin in orbital lymphangioma. ( 28300684 )
2017
19
Peri-Punctal Lymphangioma Treated With Bleomycin. ( 28863118 )
2017
20
A Large Hemispherical Colon Lymphangioma. ( 28050035 )
2017
21
Cystic lymphangioma in a 44-year-old woman. ( 28451011 )
2017
22
An adult case of lymphangioma of the hepatoduodenal ligament mimicking a hepatic cyst. ( 28050777 )
2017
23
WITHDRAWN: Role of Intralesional Bleomycin in Orbital Lymphangioma: A Prospective Study. ( 28579136 )
2017
24
Gastrointestinal: Giant mesenteric cystic lymphangioma. ( 28221691 )
2017
25
Large Omental Cystic Lymphangioma Masquerading as Mucinous Ovarian Neoplasia in an 8-Year-Old Premenarchal Girl: The Findings from Diagnostic Imaging and Laparoscopic-Assisted Excision. ( 28629796 )
2017
26
A Rare Cause of Dyspnea: Cervicothoracic Cystic Lymphangioma. ( 28872508 )
2017
27
Dermoscopy of lymphangioma circumscriptum: A morphological study of 45 cases. ( 28752523 )
2017
28
Cardiac Lymphangioma Encasing Right Coronary Artery in an Infant. ( 28838528 )
2017
29
Dermoscopy of cutaneous lymphangioma circumscriptum. ( 28515992 )
2017
30
Recurring Giant Mediastinal Cystic Lymphangioma. ( 28363031 )
2017
31
Orbital Lymphangioma: Characteristics and Treatment Outcomes of 12 Cases. ( 28534344 )
2017
32
Sclerotherapy for Orbital Lymphangioma - Case Series and Literature Review. ( 28358710 )
2017
33
Transient Reactive Eruptive Lymphangiectasia Following Partial Vulvectomy for Chronic Acquired Lymphangioma. ( 28859749 )
2017
34
Fibroepithelial polyp of the vulva accompanied by lymphangioma circumscriptum. ( 28791276 )
2017
35
Cystic Lymphangioma of the Pancreas: a Rare Entity. ( 27334312 )
2016
36
Severe Pain and Edema due to a Widespread Lymphangioma: Disappearance of Symptoms and Reduction of Lesion with Spinal Cord Stimulation. ( 27402439 )
2016
37
Volvulus of the jejunum on cystic lymphangioma: About a clinical case. ( 27251660 )
2016
38
High-grade squamous intraepithelial lesion arising adjacent to vulvar lymphangioma circumscriptum: a tertiary institutional experience. ( 27329721 )
2016
39
A rare case of giant mesenteric cystic lymphangioma of the small bowel in an adult: A case presentation and literature review. ( 28209109 )
2016
40
Lymphangioma Circumscriptum: Good Clinical Response to Isotretinoin Therapy. ( 27041148 )
2016
41
Diagnosis of cystic lymphangioma of the colon by endoscopic ultrasound: Biopsy is not needed! ( 27803907 )
2016
42
Diagnosis of perinephric retroperitoneal lymphangioma supported by contrast-enhanced ultrasound (CEUS). ( 27716656 )
2016
43
Cystic Lymphangioma of Pancreas. ( 27065694 )
2016
44
A 36-Year-Old Female with Recurrent Left Sided Pleural Effusion: A Rare Case of Mediastinal Lymphangioma. ( 27789902 )
2016
45
Mesenteric lymphangioma mimicking a cystic ovarian mass on imaging. ( 26833955 )
2016
46
Abdominal lymphangioma. ( 28050075 )
2016
47
Lymphangioma Circumscriptum of the Vulva. ( 27502262 )
2016
48
Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Findings of Post Traumatic Lymphangioma in a Young Adult Male. ( 27699163 )
2016
49
Response to OK-432 sclerotherapy in the treatment of cervical lymphangioma with submucosal extension to the airway. ( 27297957 )
2016
50
Lymphangioma Circumscriptum: A Great Mimicker. ( 27803540 )
2016

Variations for Lymphangioma

Expression for Lymphangioma

Search GEO for disease gene expression data for Lymphangioma.

Pathways for Lymphangioma

Pathways related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.44 FLT4 IFNA2 KDR SERPINF1 VEGFA VEGFC
2
Show member pathways
13.31 FLT4 IFNA2 KDR PIK3CA VEGFA VEGFC
3
Show member pathways
13.1 IFNA2 PDPN PIK3CA VEGFA VEGFC
4
Show member pathways
13.05 FLT4 KDR VEGFA VEGFC VIM
5
Show member pathways
12.69 FLT4 KDR PIK3CA VEGFA VEGFC
6
Show member pathways
12.47 FLT4 KDR PIK3CA VEGFA VEGFC
7
Show member pathways
12.38 FLT4 KDR PIK3CA VEGFA VEGFC
8 12.33 FLT4 IFNA2 KDR PIK3CA VEGFA VEGFC
9
Show member pathways
12.22 FLT4 KDR VEGFA VEGFC
10
Show member pathways
12.17 FLT4 KDR VEGFA VEGFC
11 12.09 KDR PIK3CA VEGFA
12
Show member pathways
12.03 KDR VEGFA VEGFC
13 11.91 FLT4 KDR VEGFC
14 11.89 KDR PIK3CA VEGFA
15 11.8 KDR PROX1 VEGFA VIM
16 11.74 PIK3CA VEGFA VEGFC
17
Show member pathways
11.64 FLT4 KDR PIK3CA
18 11.38 KDR PIK3CA VEGFA
19 11.32 KDR PIK3CA VEGFA
20
Show member pathways
11.2 KDR PIK3CA VEGFA
21 11.2 FLT4 KDR PROX1 VEGFC
22 11.15 KDR VEGFA
23
Show member pathways
10.98 FLT4 KDR PIK3CA VEGFA VEGFC
24 10.81 KDR PIK3CA VEGFA
25 10.69 FLT4 PIK3CA VEGFC
26 10.51 VEGFA VEGFC

GO Terms for Lymphangioma

Cellular components related to Lymphangioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lamellipodium GO:0030027 8.8 ACTC1 PDPN PIK3CA

Biological processes related to Lymphangioma according to GeneCards Suite gene sharing:

(show all 32)
id Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.99 KDR PDPN PROX1 SERPINF1 VEGFA VEGFC
2 positive regulation of cell proliferation GO:0008284 9.83 FLT4 KDR PROX1 VEGFA VEGFC
3 positive regulation of protein phosphorylation GO:0001934 9.8 FLT4 KDR VEGFA
4 regulation of cell shape GO:0008360 9.79 KDR PDPN VEGFA
5 positive regulation of angiogenesis GO:0045766 9.77 KDR VEGFA VEGFC
6 kidney development GO:0001822 9.76 PROX1 SERPINF1 VEGFA
7 lung development GO:0030324 9.73 PDPN PROX1 VEGFA
8 angiogenesis GO:0001525 9.72 FLT4 KDR PIK3CA VEGFA VEGFC
9 negative regulation of apoptotic process GO:0043066 9.71 ACTC1 FLT4 KDR VEGFA
10 lung alveolus development GO:0048286 9.65 FLT4 PDPN
11 positive regulation of cell migration GO:0030335 9.65 KDR VEGFA
12 vasculature development GO:0001944 9.64 FLT4 PIK3CA
13 positive regulation of focal adhesion assembly GO:0051894 9.64 KDR VEGFA
14 positive regulation of blood vessel endothelial cell migration GO:0043536 9.63 VEGFA VEGFC
15 positive regulation of protein autophosphorylation GO:0031954 9.62 VEGFA VEGFC
16 positive regulation of neuroblast proliferation GO:0002052 9.62 VEGFA VEGFC
17 cell migration involved in sprouting angiogenesis GO:0002042 9.61 KDR VEGFA
18 induction of positive chemotaxis GO:0050930 9.59 VEGFA VEGFC
19 positive regulation of positive chemotaxis GO:0050927 9.58 KDR VEGFA
20 lymph vessel development GO:0001945 9.57 FLT4 PROX1
21 positive regulation of cellular component movement GO:0051272 9.55 PDPN VEGFA
22 positive regulation of protein kinase C signaling GO:0090037 9.54 FLT4 VEGFA
23 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.54 FLT4 KDR VEGFA
24 vascular endothelial growth factor signaling pathway GO:0038084 9.52 FLT4 KDR
25 skeletal muscle thin filament assembly GO:0030240 9.49 ACTC1 PROX1
26 positive regulation of mast cell chemotaxis GO:0060754 9.48 VEGFA VEGFC
27 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.46 KDR VEGFA
28 positive regulation of endothelial cell migration GO:0010595 9.46 FLT4 KDR PROX1 VEGFA
29 lymphangiogenesis GO:0001946 9.43 FLT4 PDPN PROX1
30 protein kinase B signaling GO:0043491 9.35 PIK3CA
31 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.35 FLT4 KDR PIK3CA VEGFA VEGFC
32 positive regulation of endothelial cell proliferation GO:0001938 9.02 FLT4 KDR PROX1 VEGFA VEGFC

Molecular functions related to Lymphangioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 8.96 VEGFA VEGFC
2 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 FLT4 KDR

Sources for Lymphangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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