MCID: LYM008
MIFTS: 47

Lymphangiosarcoma malady

Rare diseases, Skin diseases, Immune diseases categories

Summaries for Lymphangiosarcoma

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Wikipedia:65 Lymphangiosarcoma is a rare malignant tumor which occurs in long-standing cases of primary or secondary... more...

MalaCards based summary: Lymphangiosarcoma, also known as postmastectomy extremity angiosarcoma, is related to lymphedema and sarcoma. An important gene associated with Lymphangiosarcoma is FLT4 (fms-related tyrosine kinase 4), and among its related pathways is NF-KappaB Family Pathway. The compounds ivig and rituximab have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and bone, and related mouse phenotypes are adipose tissue and liver/biliary system.

Aliases & Classifications for Lymphangiosarcoma

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Lymphangiosarcoma, Aliases & Descriptions:

Name: Lymphangiosarcoma 10 12 62
Postmastectomy Extremity Angiosarcoma 43 62
Stewart Treves Syndrome 43 62
Skin Lymphangiosarcoma 10 62
Angiosarcoma Associated with Chronic Lymphedema 43
 
Lymphangiosarcoma of Stewart and Treves 10
Lymphangiosarcoma Following Mastectomy 43
Lymphangioendothelioma, Malignant 62
Malignant Lymphangioendothelioma 10
Stewart-Treves Syndrome 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Immune diseases


External Ids:

Disease Ontology10 DOID:2689
NCIt40 C3205
MeSH35 D008204

Related Diseases for Lymphangiosarcoma

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Graphical network of the top 20 diseases related to Lymphangiosarcoma:



Diseases related to lymphangiosarcoma

Symptoms for Lymphangiosarcoma

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Drugs & Therapeutics for Lymphangiosarcoma

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Drug clinical trials:

Search ClinicalTrials for Lymphangiosarcoma

Search NIH Clinical Center for Lymphangiosarcoma

Genetic Tests for Lymphangiosarcoma

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Anatomical Context for Lymphangiosarcoma

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MalaCards organs/tissues related to Lymphangiosarcoma:

33
Skin, Breast, Bone, Lymph node, Lung, Testes, Cervix

Animal Models for Lymphangiosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Lymphangiosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8PROX1, FLT4, TNF
2MP:00053708.7TNF, FLT4, PROX1
3MP:00053818.6PROX1, FLT4, TNF
4MP:00053858.6PROX1, FLT4, TNF
5MP:00053898.2F8, FLT4, TNF
6MP:00053878.1TNF, FLT4, PROX1, F8
7MP:00053768.1F8, PROX1, FLT4, TNF
8MP:00107687.9TNF, FLT4, PROX1, F8

Publications for Lymphangiosarcoma

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Articles related to Lymphangiosarcoma:

(show top 50)    (show all 158)
idTitleAuthorsYear
1
Lymphangiosarcoma with systemic metastases in a Japanese domestic cat. (25482607)
2015
2
Stewart-Treves Phenomenon: Lymphangiosarcoma Arising in Lymphedematous Tissue Is Not a Syndrome. (25658055)
2015
3
Lymphangiosarcoma of the scalp. (24342442)
2014
4
Plasma-cell rich lymphangiosarcoma: an under-recognized variant and potential diagnostic pitfall. (22188566)
2012
5
Lymphangiosarcoma of the vocal cord: a rare entity defined by a D2-40 immunohistochemical and ultrastructural study. (20975065)
2011
6
Locally invasive lymphangiosarcoma in a young domestic shorthair. (21880529)
2011
7
Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas. (20459536)
2010
8
Lymphangiosarcoma complicating extensive congenital mixed vascular malformations. (20863270)
2010
9
Lymphangiosarcoma in a 3.5-year-old Bullmastiff bitch with vaginal prolapse, primary lymph node fibrosis and other congenital defects. (16300186)
2005
10
Cutaneous lymphangiosarcoma in a young dog: clinical, anatomopathological and lectinhistochemical description. (15109239)
2003
11
Lymphangiosarcoma in a horse. (10805986)
2000
12
Stewart-Treves syndrome: lymphangiosarcoma following mastectomy. (10651369)
2000
13
Lymphangiosarcoma (Stewart-Treves syndrome) in postmastectomy patients. (11119680)
2000
14
Guess What! Lymphangiosarcoma of Stewart-Treves. (9917177)
1998
15
Lymphangiosarcoma of the pubic region: a rare complication arising in congenital non-hereditary lymphedema. (9854166)
1998
16
Disseminated lymphangiosarcoma in a dog. (8993785)
1997
17
Lymphangiosarcoma in a young dog. (8740713)
1996
18
Lymphedema-induced lymphangiosarcoma. (7720889)
1995
19
Lymphangiosarcoma following mastectomy. (7586817)
1995
20
Lymphangiosarcoma in late-onset hereditary lymphedema: case report and nosological implications. (7747790)
1995
21
Lymphangiosarcoma in a dog. (7696420)
1994
22
Lymphangiosarcoma of arm after chronic lymphedema: a rare long-term complication after radical mastectomy in breast cancer patients. Case report and overview. (8503088)
1993
23
Lymphangiosarcoma and haemangiosarcoma in a cat. (2918111)
1989
24
Lymphangiosarcoma of the edematous thigh after radiation therapy for carcinoma of the vulva. (3972297)
1985
25
Lymphangiosarcoma in a dog. (6698882)
1984
26
Electron microscopic observations of lymphangiosarcoma arising from chronic lymphedema. (6624459)
1983
27
Canine angiosarcoma (lymphangiosarcoma). (7467082)
1981
28
Lymphangiosarcoma after filarial infection. (7229182)
1981
29
Chemotherapy for postmastectomy lymphangiosarcoma. (7226038)
1981
30
Lymphangiosarcoma of the anterior abdominal wall: a case report. (6452196)
1980
31
Test and teach number eleven. Diagnosis: post-mastectomy lymphangiosarcoma of Stewart and Treves. (876686)
1977
32
Lymphangiosarcoma arising in congenital lymphedema. (1119828)
1975
33
Lymphatics, lymphedema and lymphangiosarcoma. (1096278)
1975
34
Postmastectomy lymphangiosarcoma-temporary response to cyclophosphamide chemotherapy in 2 cases. (4811506)
1974
35
Angiosarcoma: report of three cases of postmastectomy lymphangiosarcoma and one of hemangiosarcoma. (4734252)
1973
36
Lymphangiographic studies in a case of post-mastectomy lymphangiosarcoma. (5023499)
1972
37
Lymphangiosarcoma. (16811066)
1972
38
Lymphangiosarcoma of the thigh. A case report. (5458277)
1970
39
Lymphangiosarcoma following post-mastectomy lymphedema. (5770234)
1969
40
Lymphangiosarcoma in the lymphedematous extremity. (4964996)
1967
41
Postmastectomy lymphangiosarcoma. (6076125)
1967
42
Therapy of lymphangiosarcoma of the chronically edematous limb. Five-year cure of a patient treated by intra-arterial radioactive yttrium. (4289774)
1967
43
Postmastectomy lymphangiosarcoma in the lymphedematous arm: a review of four cases. (5834725)
1965
44
LYMPHANGIOSARCOMA ARISING IN A CHRONICALLY EDEMATOUS ARM FOLLOWING RADICAL MASTECTOMY. (14270257)
1965
45
Lymphangiosarcoma in postmastectomy lymphedema. (5866201)
1965
46
Lymphangiosarcoma in postmastectomy lymphedematous arm. (13825473)
1959
47
Postmastectomy lymphangiosarcoma in elephantiasis chirurgica; Stewart and Treves syndrome. (13494640)
1957
48
Lymphangiosarcoma in postmastectomy lymphedema: five-year survival with irradiation treatment. (13231047)
1955
49
Lymphangiosarcoma of the arm following radical mastectomy. (13269040)
1955
50
Lymphangiosarcoma in postmastectomy lymphoedema. (13155501)
1954

Variations for Lymphangiosarcoma

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Expression for genes affiliated with Lymphangiosarcoma

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Search GEO for disease gene expression data for Lymphangiosarcoma.

Pathways for genes affiliated with Lymphangiosarcoma

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Pathways related to Lymphangiosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1FLT4, TNF

Compounds for genes affiliated with Lymphangiosarcoma

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Sources:
45Novoseek, 51PharmGKB, 13DrugBank, 30IUPHAR
See all sources

Compounds related to Lymphangiosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ivig459.2F8, TNF
2rituximab45 51 1311.2F8, TNF
3prednisolone45 30 1311.1F8, TNF
4ly294002459.1TNF, FLT4
5tgf beta1459.1TNF, F8
6endotoxin459.0TNF, F8
7prostacyclin458.9TNF, F8
8fibrinogen458.7TNF, F8
9dexamethasone45 51 30 1311.7F8, FLT4, TNF
10vegf458.2F8, PROX1, FLT4, TNF

GO Terms for genes affiliated with Lymphangiosarcoma

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Cellular components related to Lymphangiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5F8, FLT4, TNF

Biological processes related to Lymphangiosarcoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1lymphangiogenesisGO:00019469.6FLT4, PROX1
2positive regulation of endothelial cell migrationGO:00105959.5FLT4, PROX1
3positive regulation of endothelial cell proliferationGO:00019389.4FLT4, PROX1
4negative regulation of viral genome replicationGO:00450719.3TNF, PROX1
5positive regulation of JNK cascadeGO:00463309.2TNF, FLT4
6negative regulation of cell proliferationGO:00082859.1TNF, PROX1
7positive regulation of ERK1 and ERK2 cascadeGO:00703749.0FLT4, TNF
8positive regulation of protein phosphorylationGO:00019348.8TNF, FLT4

Molecular functions related to Lymphangiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:00442128.8PROX1, TNF
2protein bindingGO:00055158.0F8, PROX1, FLT4, TNF

Products for genes affiliated with Lymphangiosarcoma

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  • Antibodies
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Lymphangiosarcoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet