MCID: LYM008
MIFTS: 47

Lymphangiosarcoma malady

Categories: Rare diseases, Cancer diseases, Immune diseases, Skin diseases

Aliases & Classifications for Lymphangiosarcoma

Aliases & Descriptions for Lymphangiosarcoma:

Name: Lymphangiosarcoma 12 42 14 69
Stewart Treves Syndrome 50 42
Skin Lymphangiosarcoma 12 69
Angiosarcoma Associated with Chronic Lymphedema 50
Lymphangiosarcoma of Stewart and Treves 12
Lymphangiosarcoma Following Mastectomy 50
Postmastectomy Extremity Angiosarcoma 50
Malignant Lymphangioendothelioma 12
Stewart-Treves Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2689
NCIt 47 C3205 C4490

Summaries for Lymphangiosarcoma

Disease Ontology : 12 A lymphatic system cancer that has material basis in endothelial cells located in lymphatic vessels.

MalaCards based summary : Lymphangiosarcoma, also known as stewart treves syndrome, is related to angiosarcoma and lymphedema. An important gene associated with Lymphangiosarcoma is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Paclitaxel and Albumin-Bound Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include endothelial, skin and breast, and related phenotypes are cardiovascular system and cellular

Wikipedia : 71 Lymphangiosarcoma is a rare malignant tumor which occurs in long-standing cases of primary or secondary... more...

Related Diseases for Lymphangiosarcoma

Diseases related to Lymphangiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
id Related Disease Score Top Affiliating Genes
1 angiosarcoma 11.2
2 lymphedema 10.5
3 lysteria monocytoigeneses meningitis 10.3 FLT4 PROX1
4 cervical large cell neuroendocrine carcinoma 10.3 HBA1 PROX1
5 hypomelanosis of ito 10.3 FLT4 PROX1
6 pilomyxoid astrocytoma 10.3 FLT4 PROX1
7 vcl-related familial hypertrophic cardiomyopathy 10.3 F8 VWF
8 vcp-related amyotrophic lateral sclerosis/frontotemporal dementia 10.3 F8 VWF
9 congenital generalized lipodystrophy 10.2 FLT4 GJC2
10 high anorectal malformation 10.2 F8 VWF
11 chromosome 18 pericentric inversion 10.2 FLT4 PROX1 VEGFC
12 acrofacial dysostosis, patagonia type 10.2 FLT4 PROX1 VEGFC
13 headache 10.2 F8 VWF
14 intracranial cysts 10.2 FLT4 VEGFA
15 vcl-related dilated cardiomyopathy 10.2 F8 VWF
16 sarcocystosis 10.2 CD34 HBA1
17 cervix endometrial stromal tumor 10.2 CD34 HBA1
18 multiple mucosal neuroma 10.2 CD34 DSP
19 lumbar spinal canal and spinal cord meningioma 10.2 FLT4 GJC2 VEGFC
20 intracranial hypotension 10.2 HBA1 PROX1 VEGFA
21 vulvar dystrophy 10.2 CD34 HBA1
22 vesiculobullous skin disease 10.2 FLT4 HBA1 VEGFA
23 spastic ataxia 3, autosomal recessive 10.2 GJC2 MYC
24 factitious disorder 10.2 FLT4 HBA1 VEGFA
25 acromegaloid hypertrichosis syndrome 10.2 F8 VWF
26 breast juvenile papillomatosis 10.2 CD34 HBA1
27 degenerative disc disease 10.2 TNF VEGFA VWF
28 hemopneumothorax 10.1 CD34 HBA1
29 metagonimiasis 10.1 FLT4 VEGFA VEGFC
30 zellweger syndrome 10.1 TNF VEGFA VWF
31 alpha-2-macroglobulin deficiency 10.1 F8 VWF
32 oculodentodigital dysplasia 10.1 FLT4 GJC2 PROX1 VEGFC
33 oppositional defiant disorder 10.1 TNF VEGFA VWF
34 aortic aneurysm 10.1 VEGFA VEGFC VWF
35 bilateral breast cancer 10.1 CD34 F8 HBA1
36 fiedler's myocarditis 10.1 TNF VEGFA VWF
37 lateral sclerosis 10.1 HBA1 LYVE1 PROX1
38 dermoid cyst 10.1 CD34 HBA1 VWF
39 gerstmann syndrome 10.1 CD34 F8 HBA1
40 orofaciodigital syndrome 13 10.1 FLT4 PDPN
41 ossifying fibromyxoid tumor 10.1 CD34 HBA1 VWF
42 superior vena cava angiosarcoma 10.1 CD34 HBA1
43 ulcerative proctitis 10.1 LYZ TNF VEGFA
44 laryngeal adenoid cystic carcinoma 10.1 CD34 HBA1 VEGFA
45 membranoproliferative glomerulonephritis 10.1 F8 TNF VWF
46 pleomorphic adenoma 10.1 CD34 HBA1 MYC
47 basophil adenoma 10.1 CD34 HBA1 MYC
48 ovarian lymphoma 10.1 CD34 HBA1 MYC
49 skin angiosarcoma 10.1 CD34 HBA1 MYC
50 breast mucoepidermoid carcinoma 10.1 CD34 HBA1 MYC

Graphical network of the top 20 diseases related to Lymphangiosarcoma:



Diseases related to Lymphangiosarcoma

Symptoms & Phenotypes for Lymphangiosarcoma

MGI Mouse Phenotypes related to Lymphangiosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.22 DSP FLT4 LYVE1 LYZ MYC PDPN
2 cellular MP:0005384 10.16 VEGFA VWF CD34 DSP GJC2 LYVE1
3 hematopoietic system MP:0005397 10.14 CD34 F8 GJC2 LYVE1 LYZ MYC
4 immune system MP:0005387 10.13 CD34 F8 FLT4 GJC2 LYVE1 LYZ
5 homeostasis/metabolism MP:0005376 10.11 CD34 F8 FLT4 LYZ MYC PDPN
6 digestive/alimentary MP:0005381 10.09 FLT4 LYZ MYC PDPN PROX1 TNF
7 integument MP:0010771 9.86 CD34 DSP FLT4 LYZ MYC PDPN
8 mortality/aging MP:0010768 9.73 VEGFA VEGFC VWF DSP F8 FLT4
9 liver/biliary system MP:0005370 9.63 FLT4 LYZ MYC PROX1 TNF VEGFA
10 no phenotypic analysis MP:0003012 9.1 FLT4 LYZ MYC TNF VEGFA VWF

Drugs & Therapeutics for Lymphangiosarcoma

Drugs for Lymphangiosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2 Albumin-Bound Paclitaxel Phase 2
3 Antimitotic Agents Phase 2
4 Antineoplastic Agents, Phytogenic Phase 2
5
Fluorouracil Approved Phase 1 51-21-8 3385
6
Belinostat Approved, Investigational Phase 1 866323-14-0
7 Histone Deacetylase Inhibitors Phase 1
8 Androgens Phase 1
9 Immunosuppressive Agents Phase 1
10 Antimetabolites Phase 1
11 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Paclitaxel in Treating Patients With Locally Advanced or Metastatic Soft Tissue Angiosarcoma or Lymphangiosarcoma That Cannot Be Removed By Surgery Completed NCT00217607 Phase 2
2 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1

Search NIH Clinical Center for Lymphangiosarcoma

Cochrane evidence based reviews: lymphangiosarcoma

Genetic Tests for Lymphangiosarcoma

Anatomical Context for Lymphangiosarcoma

MalaCards organs/tissues related to Lymphangiosarcoma:

39
Endothelial, Skin, Breast, Lung, Testes, Lymph Node, Cervix

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphangiosarcoma:

18
Lymphatic Vessels

Publications for Lymphangiosarcoma

Articles related to Lymphangiosarcoma:

(show top 50) (show all 163)
id Title Authors Year
1
Modeling lymphangiosarcoma in mice. ( 27105012 )
2016
2
Lymphangiosarcoma: Is Stewart-Treves Syndrome a Preventable Condition? ( 26584023 )
2016
3
Stewart-Treves Phenomenon: Lymphangiosarcoma Arising in Lymphedematous Tissue Is Not a Syndrome. ( 25658055 )
2015
4
Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling. ( 26777415 )
2015
5
Lymphangiosarcoma with systemic metastases in a Japanese domestic cat. ( 25482607 )
2015
6
Lymphangiosarcoma with bone formation of the auricle in a dog. ( 25716121 )
2015
7
Presumed primary ocular lymphangiosarcoma with metastasis in a miniature horse. ( 25581559 )
2015
8
Lymphangiosarcoma of mons pubis following radiotherapy for carcinoma cervix. ( 25404831 )
2014
9
Lymphangiosarcoma in 12 dogs: a case series (1998-2013). ( 24612140 )
2014
10
Lymphangiosarcoma with strong positivity of D2-40 and LYVE-1 presenting different clinical features from angiosarcoma. ( 24985547 )
2014
11
Mailgnant degeneration to lymphangiosarcoma of a chronic lymphedema in the lower left extremity. ( 25304756 )
2014
12
Lymphangiosarcoma of the scalp. ( 24342442 )
2014
13
Lymphangiosarcoma of the scalp. ( 24636440 )
2014
14
Complex karyotype in a case of cutaneous lymphangiosarcoma associated with chronic lymphedema of the lower limb. ( 24947410 )
2014
15
An unusual case of skin metastasis from a breast cancer mimicking a lymphangiosarcoma. ( 24977428 )
2014
16
Cutaneous lymphangiosarcoma following chronic lymphedema of filarial origin. ( 23372218 )
2013
17
Chronic lymphedema of filarial origin: a very rare etiology of cutaneous lymphangiosarcoma. ( 23372219 )
2013
18
A novel approach to treatment of lymphangiosarcoma in a boxer dog. ( 23560802 )
2013
19
Elevated coagulation factor VIII plasma activity in a patient with lymphangiosarcoma. ( 23154736 )
2012
20
Lymphangiosarcoma of the thorax and thoracic vertebrae in a 16-year-old girl. ( 22915659 )
2012
21
Establishment and characterization of a novel lymphangiosarcoma cell line (MO-LAS) compared with the hemangiosarcoma cell line (ISO-HAS). ( 23342252 )
2012
22
Use of surgery and mitoxantrone chemotherapy in a dog with disseminated lymphangiosarcoma. ( 23216040 )
2012
23
Lymphangiosarcoma and filariasis. ( 22575002 )
2012
24
Lymphangiosarcoma arising after 33 years within a background of chronic filariasis: a case report with review of literature. ( 22211335 )
2012
25
Plasma-cell rich lymphangiosarcoma: an under-recognized variant and potential diagnostic pitfall. ( 22188566 )
2012
26
Locally invasive lymphangiosarcoma in a young domestic shorthair. ( 21880529 )
2011
27
Lymphangiosarcoma of the vocal cord: a rare entity defined by a D2-40 immunohistochemical and ultrastructural study. ( 20975065 )
2011
28
FDG-PET/CT imaging in a patient with lymphangiosarcoma. ( 20479592 )
2010
29
Lymphangiosarcoma complicating extensive congenital mixed vascular malformations. ( 20863270 )
2010
30
Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas. ( 20459536 )
2010
31
Fatal lymphangiosarcoma revealed by lymphoedema of the neck. ( 19479140 )
2009
32
Lymphangiosarcoma of the arm presenting with lymphedema in a woman 16 years after mastectomy: a case report. ( 19918554 )
2009
33
Paresis in an Asian small clawed otter (Aonyx cinereus) associated with vertebral and ischial osteolysis caused by a malignant lymphangiosarcoma. ( 18634215 )
2008
34
Lymphangiosarcoma in the nictitating membrane of a horse. ( 18182523 )
2008
35
Lymphangiosarcoma presenting as asymptomatic swelling of the cheek. ( 17317502 )
2007
36
Lymphangiosarcoma in a cat. ( 17706243 )
2007
37
Lymphangiosarcoma in two cats. ( 17307008 )
2007
38
Case 3. Upper limb lymphangiosarcoma following breast cancer therapy. ( 16549844 )
2006
39
Lymphangiosarcoma in a 3.5-year-old Bullmastiff bitch with vaginal prolapse, primary lymph node fibrosis and other congenital defects. ( 16300186 )
2005
40
Lymphangiosarcoma of dogs: a review. ( 16300179 )
2005
41
Feline lymphangiosarcoma--definitive identification using a lymphatic vascular marker. ( 14989700 )
2004
42
Lymphangiosarcoma associated with primary lymphedema in a Bouvier des Flandres. ( 14765744 )
2004
43
Lymphangiosarcoma in a dog treated with surgery and chemotherapy. ( 15031550 )
2004
44
Cutaneous lymphangiosarcoma in a young dog: clinical, anatomopathological and lectinhistochemical description. ( 15109239 )
2003
45
Metastatic lymphangiosarcoma in a horse. ( 12009065 )
2002
46
Isolated limb perfusion with tumor necrosis factor and melphalan for nonresectable sSewart-Treves lymphangiosarcoma. ( 12464594 )
2002
47
Chylothorax in a dog with pulmonary lymphangiosarcoma. ( 11204481 )
2001
48
Lymphangiosarcoma (Stewart-Treves syndrome) in postmastectomy patients. ( 11119680 )
2000
49
Stewart-Treves syndrome: lymphangiosarcoma following mastectomy. ( 10651369 )
2000
50
Lymphangiosarcoma in a horse. ( 10805986 )
2000

Variations for Lymphangiosarcoma

Expression for Lymphangiosarcoma

Search GEO for disease gene expression data for Lymphangiosarcoma.

Pathways for Lymphangiosarcoma

GO Terms for Lymphangiosarcoma

Cellular components related to Lymphangiosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CD34 F8 FLT4 HBA1 LYZ TNF
2 platelet alpha granule lumen GO:0031093 8.92 F8 VEGFA VEGFC VWF

Biological processes related to Lymphangiosarcoma according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.89 CD34 MYC TNF VEGFA
2 positive regulation of cell proliferation GO:0008284 9.8 FLT4 MYC PROX1 VEGFA VEGFC
3 platelet activation GO:0030168 9.76 F8 PDPN VWF
4 positive regulation of angiogenesis GO:0045766 9.75 CD34 VEGFA VEGFC
5 single organismal cell-cell adhesion GO:0016337 9.73 CD34 DSP PDPN
6 lung development GO:0030324 9.71 PDPN PROX1 VEGFA
7 response to wounding GO:0009611 9.65 LYVE1 MYC VWF
8 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.63 FLT4 VEGFA VEGFC
9 positive regulation of protein autophosphorylation GO:0031954 9.62 VEGFA VEGFC
10 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.62 FLT4 VEGFA
11 positive regulation of blood vessel endothelial cell migration GO:0043536 9.61 VEGFA VEGFC
12 positive regulation of neuroblast proliferation GO:0002052 9.61 VEGFA VEGFC
13 blood coagulation, intrinsic pathway GO:0007597 9.6 F8 VWF
14 oxygen transport GO:0015671 9.57 HBA1 MYC
15 induction of positive chemotaxis GO:0050930 9.55 VEGFA VEGFC
16 positive regulation of epithelial cell proliferation GO:0050679 9.54 MYC VEGFA VEGFC
17 lymph vessel development GO:0001945 9.52 FLT4 PROX1
18 negative regulation of glucose import GO:0046325 9.51 MYC TNF
19 positive regulation of cellular component movement GO:0051272 9.49 PDPN VEGFA
20 platelet degranulation GO:0002576 9.46 F8 VEGFA VEGFC VWF
21 positive regulation of protein kinase C signaling GO:0090037 9.43 FLT4 VEGFA
22 positive regulation of endothelial cell migration GO:0010595 9.43 FLT4 PROX1 VEGFA
23 positive regulation of mast cell chemotaxis GO:0060754 9.32 VEGFA VEGFC
24 positive regulation of endothelial cell proliferation GO:0001938 9.26 FLT4 PROX1 VEGFA VEGFC
25 lymphangiogenesis GO:0001946 8.8 FLT4 PDPN PROX1

Sources for Lymphangiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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