MCID: LYM008
MIFTS: 47

Lymphangiosarcoma malady

Rare diseases, Cancer diseases, Skin diseases, Immune diseases categories
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Summaries for Lymphangiosarcoma

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Lymphangiosarcoma is a rare malignant tumor which occurs in long-standing cases of primary or secondary... more...

MalaCards: Lymphangiosarcoma, also known as skin lymphangiosarcoma, is related to lymphedema and sarcoma. An important gene associated with Lymphangiosarcoma is FLT4 (fms-related tyrosine kinase 4), and among its related pathways is NF-KappaB Family Pathway. The compounds ivig and rituximab have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lung, and related mouse phenotypes are adipose tissue and liver/biliary system.

Aliases & Classifications for Lymphangiosarcoma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 62UMLS, 35MeSH, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases, Immune diseases


Aliases & Descriptions:

lymphangiosarcoma 8 10 62
skin lymphangiosarcoma 8 62
angiosarcoma associated with chronic lymphedema 43
lymphangiosarcoma of stewart and treves 8
lymphangiosarcoma following mastectomy 43
postmastectomy extremity angiosarcoma 43
malignant lymphangioendothelioma 8
stewart-treves syndrome 8
stewart treves syndrome 43


External Ids:

Disease Ontology8 DOID:2689
MeSH35 D008204
NCIt40 C3205

Related Diseases for Lymphangiosarcoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lymphangiosarcoma:



Diseases related to lymphangiosarcoma

Symptoms for Lymphangiosarcoma

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Drugs & Therapeutics for Lymphangiosarcoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Lymphangiosarcoma

Search NIH Clinical Center for Lymphangiosarcoma

Genetic Tests for Lymphangiosarcoma

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Anatomical Context for Lymphangiosarcoma

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33MalaCards
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MalaCards organs/tissues related to Lymphangiosarcoma:

33
Skin, Breast, Lung, Lymph node, Testes

Animal Models for Lymphangiosarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Lymphangiosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.8PROX1, FLT4, TNF
2MP:00053708.7TNF, FLT4, PROX1
3MP:00053818.6PROX1, FLT4, TNF
4MP:00053858.6PROX1, FLT4, TNF
5MP:00053898.2F8, FLT4, TNF
6MP:00053878.1TNF, FLT4, PROX1, F8
7MP:00053768.1F8, PROX1, FLT4, TNF
8MP:00107687.9TNF, FLT4, PROX1, F8

Publications for Lymphangiosarcoma

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52PubMed
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Articles related to Lymphangiosarcoma:

(show top 50)    (show all 149)
idTitleAuthorsYear
1
Lymphangiosarcoma of the scalp. (24342442)
2014
2
A novel approach to treatment of lymphangiosarcoma in a boxer dog. (23560802)
2013
3
Plasma-cell rich lymphangiosarcoma: an under-recognized variant and potential diagnostic pitfall. (22188566)
2012
4
Lymphangiosarcoma of the vocal cord: a rare entity defined by a D2-40 immunohistochemical and ultrastructural study. (20975065)
2011
5
Locally invasive lymphangiosarcoma in a young domestic shorthair. (21880529)
2011
6
Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas. (20459536)
2010
7
Lymphangiosarcoma complicating extensive congenital mixed vascular malformations. (20863270)
2010
8
Lymphangiosarcoma in a 3.5-year-old Bullmastiff bitch with vaginal prolapse, primary lymph node fibrosis and other congenital defects. (16300186)
2005
9
Cutaneous lymphangiosarcoma in a young dog: clinical, anatomopathological and lectinhistochemical description. (15109239)
2003
10
Lymphangiosarcoma in a horse. (10805986)
2000
11
Stewart-Treves syndrome: lymphangiosarcoma following mastectomy. (10651369)
2000
12
Lymphangiosarcoma (Stewart-Treves syndrome) in postmastectomy patients. (11119680)
2000
13
Guess What! Lymphangiosarcoma of Stewart-Treves. (9917177)
1998
14
Lymphangiosarcoma of the pubic region: a rare complication arising in congenital non-hereditary lymphedema. (9854166)
1998
15
Disseminated lymphangiosarcoma in a dog. (8993785)
1997
16
Lymphangiosarcoma in a young dog. (8740713)
1996
17
Lymphedema-induced lymphangiosarcoma. (7720889)
1995
18
Lymphangiosarcoma following mastectomy. (7586817)
1995
19
Lymphangiosarcoma in late-onset hereditary lymphedema: case report and nosological implications. (7747790)
1995
20
Lymphangiosarcoma in a dog. (7696420)
1994
21
Lymphangiosarcoma of arm after chronic lymphedema: a rare long-term complication after radical mastectomy in breast cancer patients. Case report and overview. (8503088)
1993
22
Lymphangiosarcoma and haemangiosarcoma in a cat. (2918111)
1989
23
Lymphangiosarcoma of the edematous thigh after radiation therapy for carcinoma of the vulva. (3972297)
1985
24
Lymphangiosarcoma in a dog. (6698882)
1984
25
Electron microscopic observations of lymphangiosarcoma arising from chronic lymphedema. (6624459)
1983
26
Canine angiosarcoma (lymphangiosarcoma). (7467082)
1981
27
Lymphangiosarcoma after filarial infection. (7229182)
1981
28
Chemotherapy for postmastectomy lymphangiosarcoma. (7226038)
1981
29
Lymphangiosarcoma of the anterior abdominal wall: a case report. (6452196)
1980
30
Test and teach number eleven. Diagnosis: post-mastectomy lymphangiosarcoma of Stewart and Treves. (876686)
1977
31
Lymphangiosarcoma arising in congenital lymphedema. (1119828)
1975
32
Lymphatics, lymphedema and lymphangiosarcoma. (1096278)
1975
33
Postmastectomy lymphangiosarcoma-temporary response to cyclophosphamide chemotherapy in 2 cases. (4811506)
1974
34
Angiosarcoma: report of three cases of postmastectomy lymphangiosarcoma and one of hemangiosarcoma. (4734252)
1973
35
Lymphangiographic studies in a case of post-mastectomy lymphangiosarcoma. (5023499)
1972
36
Lymphangiosarcoma. (16811066)
1972
37
Lymphangiosarcoma of the thigh. A case report. (5458277)
1970
38
Lymphangiosarcoma following post-mastectomy lymphedema. (5770234)
1969
39
Surgical treatment of lymphedema and treatment of lymphangiosarcoma. (5377629)
1969
40
Lymphangiosarcoma in the lymphedematous extremity. (4964996)
1967
41
Postmastectomy lymphangiosarcoma. (6076125)
1967
42
Therapy of lymphangiosarcoma of the chronically edematous limb. Five-year cure of a patient treated by intra-arterial radioactive yttrium. (4289774)
1967
43
Postmastectomy lymphangiosarcoma in the lymphedematous arm: a review of four cases. (5834725)
1965
44
LYMPHANGIOSARCOMA ARISING IN A CHRONICALLY EDEMATOUS ARM FOLLOWING RADICAL MASTECTOMY. (14270257)
1965
45
Lymphangiosarcoma in postmastectomy lymphedema. (5866201)
1965
46
Lymphangiosarcoma in postmastectomy lymphedematous arm. (13825473)
1959
47
Postmastectomy lymphangiosarcoma in elephantiasis chirurgica; Stewart and Treves syndrome. (13494640)
1957
48
Lymphangiosarcoma in postmastectomy lymphedema: five-year survival with irradiation treatment. (13231047)
1955
49
Lymphangiosarcoma of the arm following radical mastectomy. (13269040)
1955
50
Lymphangiosarcoma in postmastectomy lymphoedema. (13155501)
1954

Variations for Lymphangiosarcoma

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Expression for genes affiliated with Lymphangiosarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphangiosarcoma

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Pathways for genes affiliated with Lymphangiosarcoma

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50PathCards, 53QIAGEN
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Pathways related to Lymphangiosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1FLT4, TNF

Compounds for genes affiliated with Lymphangiosarcoma

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR
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Compounds related to Lymphangiosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ivig459.2F8, TNF
2rituximab45 51 1111.2F8, TNF
3prednisolone45 29 1111.1TNF, F8
4ly294002459.1FLT4, TNF
5tgf beta1459.1F8, TNF
6endotoxin459.0F8, TNF
7prostacyclin458.9TNF, F8
8fibrinogen458.7F8, TNF
9dexamethasone45 51 29 1111.7TNF, FLT4, F8
10vegf458.2F8, PROX1, FLT4, TNF

GO Terms for genes affiliated with Lymphangiosarcoma

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16Gene Ontology
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Cellular components related to Lymphangiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5F8, FLT4, TNF

Biological processes related to Lymphangiosarcoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1lymphangiogenesisGO:0019469.6PROX1, FLT4
2positive regulation of endothelial cell migrationGO:0105959.5PROX1, FLT4
3positive regulation of endothelial cell proliferationGO:0019389.4FLT4, PROX1
4negative regulation of viral genome replicationGO:0450719.3PROX1, TNF
5positive regulation of JNK cascadeGO:0463309.2FLT4, TNF
6negative regulation of cell proliferationGO:0082859.1PROX1, TNF
7positive regulation of ERK1 and ERK2 cascadeGO:0703749.0FLT4, TNF
8positive regulation of protein phosphorylationGO:0019348.8FLT4, TNF

Molecular functions related to Lymphangiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:0442128.8PROX1, TNF
2protein bindingGO:0055158.0F8, PROX1, FLT4, TNF

Products for genes affiliated with Lymphangiosarcoma

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  • Antibodies
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Sources for Lymphangiosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet